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Question 1
Correct
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Regarding the UK routine childhood immunisation schedule which of the following vaccines is given at 3 months:
Your Answer: Rotavirus
Explanation:At 3 months the following vaccines are given:
Diphtheria, tetanus, pertussis, polio, Hib and hepatitis B (2nd dose)
Pneumococcal (13 serotypes)
Rotavirus (2nd dose) -
This question is part of the following fields:
- Immunoglobulins And Vaccines
- Pharmacology
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Question 2
Incorrect
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Regarding the routine childhood immunisation schedule, which of the following vaccines is given to preschool children (aged 3 years and 4 months):
Your Answer:
Correct Answer: Measles, mumps and rubella (MMR)
Explanation:The current UK childhood immunisation schedule is as follows:
8 weeks:
DTaP/IPV(polio)/Hib/Hep B (diptheria, tetanus, pertussis, polio,Haemophilus influenzatype b and hepatitis B) – 6-in-one injection (Infranix hexa);plus:
Rotavirus gastroenteritis (Rotarix) – oral route (drops)
Meningitis B (Bexsero)12 weeks:
DTaP/IPV(polio)/Hib/Hep B – 2nddose: 6-in-one injection, 2nddose (Infranix hexa);plus:
PCV (pneumococcal conjugate vaccine) – in a separate injection (Prevenar 13)
Rotavirus gastroenteritis 2nddose (Rotarix) – oral route (drops)16 weeks:
DTaP/IPV(polio)/Hib/Hep B – 3rddose: 6-in-one injection, 3rddose (Infranix hexa);plus:
Meningitis B 2nddose (Bexsero)
Between 12 and 13 months:
Hib/Men C (combined as one injection) – 4th dose of Hib and 1stdose of Meningitis C (Menitorix);plus:
MMR (measles, mumps and rubella) – combined as one injection (Priorix or M-M-RVAXPRO);plus:
PCV (pneumococcal conjugate vaccine) – 2nddose in a separate injection (Prevenar 13);plus:
Meningitis B 3rddose (Bexsero)From 2 to end of primary school:
Nasal flu spray (Fluenz Tetra). For children aged 2,3 and 4, this is usually given in the GP surgery. Children in school years 1,2 and 3 may have this at school.3 years and 4 months:
Pre-school booster of DTaP/IPV (polio) – 4-in-one injection (Repevax or Infanrix-IPV);plus:
MMR – 2nd dose (Priorix or M-M-RVAXPRO) – in a separate injectionBetween 12 and 13 years:
HPV (human papilloma virus types 6,11, 16 and 18) –twoinjections of Gardasil given. The second injection is given 6-24 months after the first one.14 years:
Td/IPV (polio) booster – 3-in-one injection (Revaxis)
Men ACWY: combined protection against meningitis A, C, W and Y (Nimenrix or Menveo)The BCG vaccination against tuberculosis is only offered to neonates in high-risk areas or with high-risk backgrounds. When required it is usually given before leaving the hospital soon after birth.
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This question is part of the following fields:
- Immunoglobulins And Vaccines
- Pharmacology
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Question 3
Incorrect
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Normal human immunoglobulin is mostly used to protect against which of the following infectious diseases?
Your Answer:
Correct Answer: Measles and hepatitis A
Explanation:Immune globulin IM is indicated for prophylaxis following exposure
to hepatitis A, to prevent or modify measles (rubeola) in a
susceptible person exposed fewer than 6 days previously,
for susceptible household contacts of measles patients,
particularly contacts <1 year and pregnant women without
evidence of immunity, and to modify rubella in exposed pregnant
women who will not consider a therapeutic abortion. -
This question is part of the following fields:
- Immunoglobulins And Vaccines
- Pharmacology
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Question 4
Incorrect
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Which of the following is an example of a vaccine produced by recombinant DNA technology:
Your Answer:
Correct Answer: Hepatitis B
Explanation:Hepatitis B vaccines are prepared from the viral surface antigen. The recombinant vaccine is now the most widely used vaccine and induces a sufficient antibody response in 90% of individuals.
Indications for hepatitis B vaccination include:
All health care professional’s working in the UK
Other professions with occupational risks (foster carers, staff of custodial institutions, morticians etc)
Babies of mothers with hepatitis B during pregnancy
Close family contacts of a case or carrier
IV drug abusers
Individuals with haemophilia
Individuals with chronic renal failure
Sex workers and individuals with frequently changing sexual partners
The vaccine should be stored between 2 and 8 degrees C as freezing destroys its efficacy. The vaccine is administered intramuscularly, either into the deltoid region (preferred) or anterolateral thigh. The buttock should be avoided as it reduces the efficacy of the vaccine.
The standard regime is to give 3 doses of the vaccine, the 1stand 2ndone month apart and the 2ndand 3rdsix months apart. Antibody titres should be tested 2 to 4 months after the primary course.
A peak titre above 100 mIU/ml is regarded as a good response and implies long-term immunity. A peak titre between 10-100 mIU/ml is regarded as a low response and a peak titre of less than 10mIU/ml is regarded as a poor response.
There is no substantiated association between hepatitis B vaccination and Guillain-Barre syndrome. -
This question is part of the following fields:
- Immunoglobulins And Vaccines
- Pharmacology
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Question 5
Incorrect
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Regarding the UK routine childhood immunisation schedule which of the following vaccines is NOT given at 12 months:
Your Answer:
Correct Answer: Polio
Explanation:At 12 months the following vaccines are given:
Hib (4th dose) and Meningococcal group CPneumococcal (13 serotypes) (2nd dose)
Measles, mumps and rubella
Meningococcal group B (3rd dose) -
This question is part of the following fields:
- Immunoglobulins And Vaccines
- Pharmacology
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Question 6
Incorrect
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Regarding the UK routine childhood immunisation schedule which of the following vaccines is NOT given at 4 months:
Your Answer:
Correct Answer: Rotavirus
Explanation:At 4 months the following vaccines are given:
Diphtheria, tetanus, pertussis, polio, Hib and hepatitis B (3rd dose)
Meningococcal group B (2nd dose) -
This question is part of the following fields:
- Immunoglobulins And Vaccines
- Pharmacology
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Question 7
Incorrect
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Which of the following statements is correct regarding anti-D immunoglobulin?
Your Answer:
Correct Answer: It is administered as part of routine antenatal care for rhesus-negative mothers.
Explanation:In all non-sensitised pregnant women who are RhD-negative, it is recommended that routine antenatal anti-D prophylaxis is offered. Even if there is previous anti-D prophylaxis, use of routine antenatal anti-D prophylaxis should be given for a sensitising event early in the same pregnancy. Postpartum anti-D prophylaxis should also be given even if there has been previous routine antenatal anti-D prophylaxis or antenatal anti-D prophylaxis for a sensitising event in the same pregnancy.
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This question is part of the following fields:
- Immunoglobulins And Vaccines
- Pharmacology
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Question 8
Incorrect
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Disease specific immunoglobulin is available for all of the following infectious diseases EXCEPT for:
Your Answer:
Correct Answer: Hepatitis A
Explanation:Disease specific immunoglobulins are available for:
hepatitis B
rabies
tetanus
varicella-zoster
Normal immunoglobulin can be used to confer protection against hepatitis A. -
This question is part of the following fields:
- Immunoglobulins And Vaccines
- Pharmacology
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Question 9
Incorrect
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Regarding the UK routine childhood immunisation schedule which of the following vaccines is NOT given at 2 months:
Your Answer:
Correct Answer: Meningococcal group C
Explanation:At 2 months the following vaccines are given:
Diphtheria, tetanus, pertussis, polio, Haemophilus influenzae type b (Hib) and hepatitis B
Rotavirus gastroenteritis
Meningococcal group B -
This question is part of the following fields:
- Immunoglobulins And Vaccines
- Pharmacology
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