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  • Question 1 - A 39 year-old engineer presents with progressive weakness of his hands. Upon examination,...

    Incorrect

    • A 39 year-old engineer presents with progressive weakness of his hands. Upon examination, you notice wasting of the small muscles of the hand. A diagnosis of syringomyelia is suspected. Which one of the following features would most support this diagnosis?

      Your Answer: Loss of light touch sensation in the hands

      Correct Answer: Loss of temperature sensation in the hands

      Explanation:

      Syringomyelia is a development of a cavity (syrinx) within the spinal cord. Signs and symptoms include loss of feeling, paralysis, weakness, and stiffness in the back, shoulders, and extremities. Syringomyelia may also cause a loss of the ability to feel extremes of hot or cold, especially in the hands. Symptoms typically vary depending on the extent and, often more critically, on the location of the syrinx within the spinal cord.

    • This question is part of the following fields:

      • Neurology
      1
      Seconds
  • Question 2 - A 23-year-old designer is requesting the combined oral contraceptive pill. During the history...

    Incorrect

    • A 23-year-old designer is requesting the combined oral contraceptive pill. During the history taking, she states that in the past she has had migraines with aura. She asks why the combined oral contraceptive pill is contraindicated. Which of the following is the most appropriate response?

      Your Answer:

      Correct Answer: Significantly increased risk of ischaemic stroke

      Explanation:

      SIGN produced guidelines in 2008 on the management of migraines. Key points include that if patients have migraines with aura then the combined oral contraceptive (COC) is absolutely contraindicated due to an increased risk of stroke (relative risk 8.72).

    • This question is part of the following fields:

      • Neurology
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  • Question 3 - A 66 year-old marketing analyst presents to the respiratory clinic with a 2-month...

    Incorrect

    • A 66 year-old marketing analyst presents to the respiratory clinic with a 2-month history of progressive weakness and shortness of breath. He finds it difficult to stand from sitting, and struggles climbing stairs. He is an ex-smoker with chronic obstructive pulmonary disease (COPD). He had a recent exacerbation one month ago for which he was treated by the GP with a course of oral prednisolone, during which time his weakness transiently improved. On examination, you note a left-sided monophonic wheeze and reduced breath sounds at the left lung base. Blood tests and a chest x-ray are requested.

      Hb 145 g/L
      WCC10.5 109/L,
      Na+136 mmol/L,
      K+ 4.3 mmol/L,
      Urea 6.8 mmol/L,
      Creatinine 93 mmol/L,
      Calcium 2.62 mmol/L,
      Phosphate 1.44 mmol/L,


      Chest x-ray shows hyperinflated lungs, left lower lobe collapse and a bulky left hilum

      What is the most likely cause of this patient's weakness?

      Your Answer:

      Correct Answer: Lambert-Eaton myasthenic syndrome

      Explanation:

      This man has a small-cell lung cancer (SCLC) and associated Lambert-Eaton myasthenic syndrome – a well-recognized paraneoplastic manifestation of SCLC. This classically affects the proximal muscles, especially in the legs, causing difficulty in standing from a seated position and climbing stairs. In contrast to myasthenia gravis, eye involvement is uncommon. Treatment with steroids is often helpful, which explains his transient symptomatic improvement during treatment for his COPD exacerbation. Steroid myopathy does not fit as the symptoms started well before his course of prednisolone. Although the patient is mildly hypercalcaemic, this would not be sufficient to produce his presenting symptoms, although it does reinforce the suspicion of lung malignancy. Motor neurone disease would be unlikely in this context and would not improve with steroids. Myasthenia gravis could produce these symptoms, but in the context of a new lung mass is a less viable diagnosis.

    • This question is part of the following fields:

      • Neurology
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  • Question 4 - A 37-year-old teacher with multiple sclerosis complains that her vision becomes blurred during...

    Incorrect

    • A 37-year-old teacher with multiple sclerosis complains that her vision becomes blurred during a hot bath. Which of the following explain this?

      Your Answer:

      Correct Answer: Uhthoff's phenomenon

      Explanation:

      Uhthoff’s phenomenon is worsening of vision following a rise in body temperature.
      Lhermitte’s sign describes paraesthesia in the limbs on neck flexion.
      Oppenheim’s sign is seen when scratching of the inner side of leg leads to extension of the toes. It is a sign of cerebral irritation and is not related to multiple sclerosis.
      Werdnig-Hoffman’s disease is also known as spinal muscular atrophy.

    • This question is part of the following fields:

      • Neurology
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  • Question 5 - Causes of dilated pupils include which of the following? ...

    Incorrect

    • Causes of dilated pupils include which of the following?

      Your Answer:

      Correct Answer: Ethylene glycol poisoning

      Explanation:

      Ethylene glycol poisoning is the only poison listed that will cause dilation of the pupils whereas all the other listed conditions and poisons will present with small pupils other than in the case of Myotonic dystrophy wherein the patient will present with a cortical cataract.

    • This question is part of the following fields:

      • Neurology
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  • Question 6 - A 43-year-old police officer is admitted with a history of unsteadiness and slurring...

    Incorrect

    • A 43-year-old police officer is admitted with a history of unsteadiness and slurring of speech. This has worsened over a period of three months. He complains of a tremor affecting his right hand and diplopia on right lateral gaze. He smokes 30 cigarettes a day and takes regular diclofenac for his arthritis. On examination, he is dysarthric and feels nauseated. Fundoscopy is normal, however there is marked horizontal nystagmus and evidence of a right VI nerve palsy. There also appears to be some mild facial weakness on the right side. Upon conducting Weber’s test, a louder tone is heard in the left ear. On conducting the Rinne test, both ears are normal. On examination of the upper limb, there is a right intention tremor and dysdiadochokinesis. Tone, power and reflexes are normal. On examination of the lower limb, tone, power and reflexes are normal, however he appears to walk with a broad-based gait and is leaning to the right.

      Lumbar puncture:

      Opening pressure 13 cm H20 (5–18)
      Protein 0.67 g/l (0.15–0.45)
      WCC 3 cells/ml (<5)
      Red cell count (RCC) 2 cells/ml (<5)
      Glucose 3.2 mmol/l (3.3–4.4)
      Blood glucose 5.8 mmol/l (3.0–6.0)
      Oligoclonal bands Present
      Serum oligoclonal bands Present

      Magnetic resonance scan shows a calcified lesion broadly attached to the petrous part of the temporal bone. In view of the above history and findings, what is the likely cause of this patient’s symptoms?

      Your Answer:

      Correct Answer: Meningioma of the cerebellar pontine angle

      Explanation:

      This patient has a combination of right cerebellar dysfunction with right-sided cranial nerve palsies (VI, VII, and VIII). The magnetic resonance imaging (MRI) shows a calcified meningioma within the right cerebellar pontine area, which would account for these findings. The cerebrospinal fluid (CSF) analysis shows oligoclonal bands, however, these are matched in the serum, which reflects a systemic inflammatory response from his rheumatoid arthritis.

      The MRI scan and CSF analysis would not be consistent with progressive multiple sclerosis. The progressive nature of her symptoms would be against a diagnosis of brainstem infarct, and one would expect more pyramidal signs in the peripheral nervous system.

    • This question is part of the following fields:

      • Neurology
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  • Question 7 - Which of the following peripheral neuropathy inducing clinical diagnoses is predominantly associated with...

    Incorrect

    • Which of the following peripheral neuropathy inducing clinical diagnoses is predominantly associated with sensory loss?

      Your Answer:

      Correct Answer: Uraemia

      Explanation:

      Diseases that cause predominantly sensory loss include diabetes, uraemia, leprosy, alcoholism, vitamin B12 deficiency, and amyloidosis.
      Those that cause predominantly motor loss include Guillain-Barre syndrome, porphyria, lead poisoning, hereditary sensorimotor neuropathies, chronic inflammatory demyelinating polyneuropathy, and diphtheria.

    • This question is part of the following fields:

      • Neurology
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  • Question 8 - A 42 year old male undergoes a routine cranial nerve examination, which reveals...

    Incorrect

    • A 42 year old male undergoes a routine cranial nerve examination, which reveals the following findings:

      Rinne's test: Air conduction > bone conduction in both ears

      Weber's test: Localizes to the right side

      What do these test results imply?

      Your Answer:

      Correct Answer: Left sensorineural deafness

      Explanation:

      Weber’s test – if there is a sensorineural problem, the sound is localized to the unaffected side (right), indicating a problem on the left side.

    • This question is part of the following fields:

      • Neurology
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  • Question 9 - Which of the following may cause a downbeat nystagmus? ...

    Incorrect

    • Which of the following may cause a downbeat nystagmus?

      Your Answer:

      Correct Answer: Chiari type I malformation

      Explanation:

      Downbeat nystagmus (DBN) suggests a lesion in the lower part of the medulla. Chiari Type I malformation usually presents with symptoms due to brain stem and lower cranial nerve dysfunction, which includes DBN.

    • This question is part of the following fields:

      • Neurology
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  • Question 10 - A 48-year-old hairdresser presents to the GP with loss of sensation over the...

    Incorrect

    • A 48-year-old hairdresser presents to the GP with loss of sensation over the lateral three and a half fingers of her right hand, tenderness over her right forearm, and inability to make a tight fist. She complains of pain in her right arm when twisting door handles anticlockwise. Phalen’s and Tinel’s tests are negative. She is otherwise neurologically intact. Which of the following is the most likely diagnosis?

      Your Answer:

      Correct Answer: Pronator teres syndrome

      Explanation:

      Entrapment of the median nerve by pronator teres causes a median nerve neuropathy, which is worse during pronation of the forearm. Examination should involve excluding carpal tunnel syndrome and pronation of the affected forearm against resistance, which brings on the pain. Unlike carpal tunnel syndrome, the median nerve proximal to the wrist may be tender to palpation.

    • This question is part of the following fields:

      • Neurology
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  • Question 11 - A 27-year-old realtor presented with progressive weakness of both legs over the last...

    Incorrect

    • A 27-year-old realtor presented with progressive weakness of both legs over the last 3 years. He complained of being unable to see well at night and having an impaired sense of smell. On examination he had a shortened fourth toe bilaterally with pes cavus. Neurological examination revealed a loss of pinprick sensation to bilateral knees, and weakness of both legs that was more prominent distally. Which of the following would be the best blood test to order to make a diagnosis?

      Your Answer:

      Correct Answer: Phytanic acid

      Explanation:

      The diagnosis is Refsum’s disease. This is an autosomal recessive disorder that causes a sensorimotor peripheral neuropathy. It is caused by defective alpha oxidation of phytanic acid leading to its accumulation in tissues. Cardiac conduction abnormalities and cardiomyopathies may also occur.
      Epiphyseal dysplasia causes a characteristic shortening of the fourth toe. Serum phytanic acid levels are elevated. Treatment is by dietary restriction of foods containing phytanic acid (dairy products, fish, beef and lamb).

    • This question is part of the following fields:

      • Neurology
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  • Question 12 - A 48-year-old hairdresser presented to her GP complaining of tingling in the right...

    Incorrect

    • A 48-year-old hairdresser presented to her GP complaining of tingling in the right palm and right wrist pain. She had intermittently experienced these symptoms; however, recently they had been keeping her awake all night. She had noticed a reduction in grip and was struggling to work at the salon. Otherwise, she felt well in herself and had not noticed any weakness in the other hand or lower limb. Her weight was stable, and she denied any neck problems or swallowing difficulties. She had a past medical history of hypothyroidism and hypertension and took regular thyroxine, Bendroflumethiazide and ibuprofen. She was a non-smoker and rarely drank alcohol. On examination, she appeared alert and orientated. Fundoscopy and cranial nerve examination were all normal and neck movements were full.

      On examination of the upper limb, there was wasting over the right thenar eminence and fasciculations with a small burn over the right index finger. There was weakness of thumb abduction and opposition, with loss of pinprick and light touch sensation over the thumb, index and middle finger in the right hand. Nerve conduction studies showed absent sensory action potential in right median palmar branches and denervation of the right abductor pollicis brevis.

      What is the most likely diagnosis?

      Your Answer:

      Correct Answer: Median nerve palsy

      Explanation:

      The history is consistent with carpal tunnel syndrome (CTS) arising as a result of pressure on the median nerve in the carpal tunnel. The median nerve supplies the muscles of the thenar eminence: the abductor pollicis (C7, C8), flexor pollicis brevis and opponens pollicis, and the lateral two lumbricals. The nerve conduction studies confirm marked denervation and absent sensory potentials within the median nerve territory.

    • This question is part of the following fields:

      • Neurology
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  • Question 13 - A 14 year-old is brought to the ED after being hit on the...

    Incorrect

    • A 14 year-old is brought to the ED after being hit on the head with a cricket ball during a match. His teacher describes that he initially collapsed on the ground and complained of a sore head. Two minutes later, he got up and said he felt OK and continued playing. However, 30 minutes later he suddenly collapsed and lost consciousness. What injury is he most likely to have sustained?

      Your Answer:

      Correct Answer: Extradural haematoma

      Explanation:

      A lucid interval, in which the patient portrays a temporary improvement in condition after a traumatic brain injury, is especially indicative of an epidural haematoma.

    • This question is part of the following fields:

      • Neurology
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  • Question 14 - A 46-year-old plumber develops chronic, severe pain after sustaining a brachial plexus injury...

    Incorrect

    • A 46-year-old plumber develops chronic, severe pain after sustaining a brachial plexus injury as a result of a motorbike accident. He has had no benefit from paracetamol or ibuprofen. In addition, he has had an unsuccessful trial of amitriptyline. Following recent NICE guidelines, which of the following is the most appropriate medication to consider?

      Your Answer:

      Correct Answer: Pregabalin

      Explanation:

      Neuropathic pain may be defined as pain which arises following damage or disruption of the nervous system. It is often difficult to treat and responds poorly to standard analgesia.
      The most recent update to the NICE guidelines for management of neuropathic pain occurred in 2013: first-line treatment* includes amitriptyline. If the first-line drug treatment does not work then move on to one of the other 3 drugs: duloxetine, gabapentin or pregabalin. Tramadol may be used as ‘rescue therapy’ for exacerbations of neuropathic pain. Topical capsaicin may be used for localised neuropathic pain (e.g. post-herpetic neuralgia). Pain management clinics may be useful in patients with resistant problems.

      *please note that for some specific conditions the guidance may vary. For example carbamazepine is used first-line for trigeminal neuralgia.

    • This question is part of the following fields:

      • Neurology
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  • Question 15 - A 48-year-old patient with diabetes is referred from the Emergency department complaining of...

    Incorrect

    • A 48-year-old patient with diabetes is referred from the Emergency department complaining of dizziness and vomiting.
      On examination he is alert and orientated, his pulse is 80 irregularly irregular and BP 160/90 mmHg. There is nystagmus on left lateral gaze and his speech is slurred. On examination of the limbs, you note intention tremor and past pointing. He is ataxic when mobilised.
      What is the likely diagnosis?

      Your Answer:

      Correct Answer: Cerebellar CVA

      Explanation:

      The patient’s presentation with slurred speech, intention tremor and past pointing, as well as ataxia and nystagmus, paired with a history of vertigo suggest the cerebellum as the site of cerebrovascular accident (CVA) or stroke.

    • This question is part of the following fields:

      • Neurology
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  • Question 16 - A 18-year-old gentleman is referred to dermatology. He has around 10 hyperpigmented macules...

    Incorrect

    • A 18-year-old gentleman is referred to dermatology. He has around 10 hyperpigmented macules on his torso which vary in size from 1.5-5 cm in size. His GP also noted some freckles in the groin region. He is also currently under orthopaedic review due to a worsening scoliosis of the spine. His father suffered from similar problems before having a fatal myocardial infarction two years ago. Which chromosome is most likely to have a gene defect?

      Your Answer:

      Correct Answer: Chromosome 17

      Explanation:

      The patient’s history and presentation and familial history, meets the diagnostic criteria for Neurofibromatosis type I, presenting with neurofibromas noted in this patient as hyperpigmented macules and freckles, musculoskeletal disorders like the scoliosis in this case, and a familial history. Neurofibromatosis type I is caused by a mutation on Chromosome 17.

    • This question is part of the following fields:

      • Neurology
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  • Question 17 - An iv-drug abuser sustains an open head injury and is admitted overnight for...

    Incorrect

    • An iv-drug abuser sustains an open head injury and is admitted overnight for observation. The next morning she is ok and is discharged. A week later she is re-admitted with fluctuating hard neurological signs. Blood results show neutrophilia and raised C-reactive protein (CRP).
      Which of the following is the best initial treatment step?

      Your Answer:

      Correct Answer: Computed tomography (CT) scan with contrast

      Explanation:

      Increased WBC count and CRP suggest infection. But with the fluctuating hard neurological signs, there is suspicion of the presence of a cerebral mass, which is an indication for requesting for a CT scan with contrast, to rule out an abscess or haematoma. The lumbar puncture can be considered after the CT scan.

    • This question is part of the following fields:

      • Neurology
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  • Question 18 - A 44 year-old electrician is referred to you complaining of increasing problems with...

    Incorrect

    • A 44 year-old electrician is referred to you complaining of increasing problems with concentration. He also complains of irregular jerky movements of his extremities and fingers. He consumes approximately 25 units of alcohol per week. His father was diagnosed with dementia at the age of 40. Apart from generalized choreiform movements, his neurological and systemic examinations were normal. Which of the following is the most likely diagnosis?

      Your Answer:

      Correct Answer: Huntington's disease

      Explanation:

      Huntington’s disease is an autosomal inherited condition characterized by progressive dementia and worsening choreiform movements. Symptoms typically appear between ages 30 and 50. Ultimately the weakened individual succumbs to pneumonia, heart failure, or other complications.

    • This question is part of the following fields:

      • Neurology
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  • Question 19 - Which one of the following medications is most useful for helping to prevent...

    Incorrect

    • Which one of the following medications is most useful for helping to prevent attacks of Meniere’s disease?

      Your Answer:

      Correct Answer: Betahistine

      Explanation:

      Betahistine is a histamine analogue that has been the mainstay treatment drug for Meniere’s disease.

    • This question is part of the following fields:

      • Neurology
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  • Question 20 - A 63-year-old gentleman presents with left-sided eye pain and diplopia for the past...

    Incorrect

    • A 63-year-old gentleman presents with left-sided eye pain and diplopia for the past 2 days. Examination of his eyes shows his pupils equal and reactive to light with no proptosis. There is however an apparent palsy of the 6th cranial nerve associated with a partial 3rd nerve palsy on the left side. Examining the remaining cranial demonstrates hyperaesthesia of the upper face on the left side. Where is the likely lesion?

      Your Answer:

      Correct Answer: Cavernous sinus

      Explanation:

      A lesion on the cavernous sinus would explain the palsy observed on the III and VI cranial nerves because the cranial nerves III, IV, V, and VI pass through the cavernous sinus. Pain in the eye is due to the nearby ophthalmic veins that feeds the cavernous sinus. Additionally, the lesions in the other structures would have presented with pupil abnormalities and less localized pain and symptoms.

    • This question is part of the following fields:

      • Neurology
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  • Question 21 - A 41-year-old yoga instructor presents with a 2-month history of left-hand weakness. She...

    Incorrect

    • A 41-year-old yoga instructor presents with a 2-month history of left-hand weakness. She has no significant past medical history. On examination, there is mild weakness of the left upper and lower limbs with a right sided facial weakness, which spares the forehead. Which of the following is the most likely location of the lesion?

      Your Answer:

      Correct Answer: Right pons

      Explanation:

      The pons is above the level of decussation of the corticospinal tracts so a pontine lesion would cause a contralateral limb weakness.
      The facial motor nucleus is located in the pons and supplies the ipsilateral facial muscles.
      A right cerebral lesion would give left upper and lower limb weakness. It would also cause a left sided facial weakness.
      A left cerebral lesion would give right upper and lower limb weakness with right facial weakness.
      Finally, a cervical spinal cord lesion would not cause a facial weakness.

    • This question is part of the following fields:

      • Neurology
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  • Question 22 - A 21 year-old software developer undergoes a planned lumbar puncture (LP) as part...

    Incorrect

    • A 21 year-old software developer undergoes a planned lumbar puncture (LP) as part of a neurological investigation for possible multiple sclerosis. During the consent process, she expresses concern about a post-LP headache. What is the mechanism of post-LP headaches?

      Your Answer:

      Correct Answer: Leaking cerebrospinal fluid from the dura

      Explanation:

      Leaking of cerebrospinal fluid from the dura is the most likely explanation for post-lumbar puncture headaches. It is thought that ongoing leak of cerebrospinal fluid (CSF) through the puncture site causes ongoing CSF loss, leading to low pressure. A post-LP headache is typically frontal or occipital and occurs within three days. It is normally associated with worsening on standing and improvement when lying down. Treatment in severe cases includes an epidural blood patch, but most resolve on their own.

    • This question is part of the following fields:

      • Neurology
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  • Question 23 - A 20-year-old gentleman presents with drop foot following a sports injury.
    On examination...

    Incorrect

    • A 20-year-old gentleman presents with drop foot following a sports injury.
      On examination there is weakness of ankle dorsiflexion and eversion, and weakness of extension of the big toe. He has some sensory loss restricted to the dorsum of his foot surrounding the base of his big toe. Other examination is within normal limits.
      Where is the most likely site of the lesion?

      Your Answer:

      Correct Answer: Common peroneal nerve at the head of the fibula

      Explanation:

      Peroneal nerve injury is also known as foot drop. The common peroneal nerve supplies the ankle and toe extensor muscle groups as well as sensation over the dorsum of the foot; thus, there is also loss of sensation in these cases.

    • This question is part of the following fields:

      • Neurology
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  • Question 24 - Which one of the following is a contraindication to the use of a...

    Incorrect

    • Which one of the following is a contraindication to the use of a triptan in the management of migraine?

      Your Answer:

      Correct Answer: A history of ischaemic heart disease

      Explanation:

      A history of ischaemic heart disease in a contraindication for prescribing triptans because they act by constricting cerebral and also coronary vessels, increasing the risk of stroke.

    • This question is part of the following fields:

      • Neurology
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  • Question 25 - A 57-year-old architect presents with weakness of the right hand. You note global...

    Incorrect

    • A 57-year-old architect presents with weakness of the right hand. You note global wasting of the small hand muscles. There is also sensory loss over the medial border of the forearm around the elbow. Which of the following nerve roots is damaged?

      Your Answer:

      Correct Answer: T1

      Explanation:

      This patient has Klumpke’s paralysis due to damage to the T1 nerve root. This root eventually supplies the median and ulnar nerves. The ulnar nerve supplies all of the intrinsic hand muscles except for those of the thenar eminence and the first and second lumbricals, which are innervated by the median nerve.

    • This question is part of the following fields:

      • Neurology
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  • Question 26 - A 6-year-old boy is referred by his GP to the neurology clinic with...

    Incorrect

    • A 6-year-old boy is referred by his GP to the neurology clinic with abnormal movements. His mother noticed that for the last year, the boy has been falling over more and more frequently. He has also been having increasingly slurred speech. These have been getting progressively worse. He has had recurrent chest infections in his childhood.

      What is the most likely diagnosis?

      Your Answer:

      Correct Answer: Ataxic telangiectasia

      Explanation:

      Ataxic telangiectasia is an inherited combined immunodeficiency disorder that is characterised by cerebellar ataxia and telangiectasia as seen in this child, as well as frequent infections as noted in this child’s history. The other differentials would not present with this clinical picture:

      Friedreich’s ataxia and Infantile-onset spinocerebellar ataxia do not present with immune problems, whereas Cerebral palsy and Di-George Syndrome do not present with ataxia.

    • This question is part of the following fields:

      • Neurology
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  • Question 27 - An 83-year-old retired musician is examined for progressive cognitive impairment. Which one of...

    Incorrect

    • An 83-year-old retired musician is examined for progressive cognitive impairment. Which one of the following features is most suggestive of Lewy body dementia?

      Your Answer:

      Correct Answer: Symptoms worsen with neuroleptics

      Explanation:

      Lewy body dementia is an increasingly recognised cause of dementia, accounting for up to 20% of cases. The characteristic pathological feature is alpha-synuclein cytoplasmic inclusions (Lewy bodies) in the substantia nigra, paralimbic and neocortical areas. Neuroleptics should be avoided in Lewy body dementia as patients are extremely sensitive and may develop irreversible parkinsonism. Questions may give a history of a patient who has deteriorated following the introduction of an antipsychotic agent.

    • This question is part of the following fields:

      • Neurology
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  • Question 28 - A 51 year-old teacher presents complaining of numerous falls. He states he has...

    Incorrect

    • A 51 year-old teacher presents complaining of numerous falls. He states he has difficulty walking up stairs, and he thinks it is because of his weak legs rather than blackouts. He is hypertensive and has suffered chronic back pain for many years. He has smoked for many years as well and has a chronic smokers cough. Upon examination, he has weakness of hip flexion and particularly knee extension. He is unable to keep his fingers flexed against force, with the right being weaker than the left. There are no sensory abnormalities and reflexes are preserved bilaterally. Which of the following is the most likely diagnosis?

      Your Answer:

      Correct Answer: Inclusion body myositis

      Explanation:

      The pattern of muscle involvement seen with quadriceps and long-finger flexors is characteristic of inclusion body myositis, an inflammatory myopathy. Polymyositis is likely to cause a predominantly proximal weakness, associated with muscle pain. The signs and symptoms are not consistent with upper cord compression, as there would likely be sensory signs, reflex changes, and possible urinary symptoms. Motor neuron disease cannot be ruled out, but there are no findings of upper motor neuron or bulbar features.

    • This question is part of the following fields:

      • Neurology
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  • Question 29 - A 10-year-old gentleman is referred with a six month history of daily headache,...

    Incorrect

    • A 10-year-old gentleman is referred with a six month history of daily headache, which is mostly frontal in location and occasionally associated with nausea.
      He has been taking paracetamol 3 g daily, aspirin 300 mg thrice daily, and codeine 40 mg thrice daily, all of which have had only a temporary effect. He has a two year history of depression treated with paroxetine. No abnormalities were found on examination.
      What is the most likely diagnosis?

      Your Answer:

      Correct Answer: Analgesic misuse headache

      Explanation:

      Because of the patient’s history of chronic analgesic use of daily paracetamol intake, the most likely diagnosis of this case is Analgesic misuse headache. In these cases, the headache is only temporarily relieved by analgesics. Treatment involves gradual withdrawal of analgesics.

    • This question is part of the following fields:

      • Neurology
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  • Question 30 - A 41-year-old gentleman undergoes a temporal lobectomy after the discovery of a brain...

    Incorrect

    • A 41-year-old gentleman undergoes a temporal lobectomy after the discovery of a brain tumour. Which one of the following consequences would be least likely to develop?

      Your Answer:

      Correct Answer: Astereognosis

      Explanation:

      Astereognosis is associated with lesions to the parietal lobe, not the temporal lobe, so this symptom would not arise in this patient.

    • This question is part of the following fields:

      • Neurology
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