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  • Question 1 - A 25 year old woman who is a known diabetic is brought to...

    Correct

    • A 25 year old woman who is a known diabetic is brought to the ED with diabetic ketoacidosis. She promptly received an insulin infusion. Which of the following are expected to increase upon infusion of insulin?

      Your Answer: Blood pH

      Explanation:

      Ketoacidosis is characterized by hyperglycaemia, glycosuria, hyperkalaemia, and metabolic acidosis with respiratory compensation. An insulin infusion would be able to address these by lowering blood glucose through increased insulin-mediated cellular uptake, lowering urine glucose concentration as cellular glucose uptake is increased, decreasing K+ in her blood by shifting it into cells, and increasing blood ph by addressing the metabolic acidosis. The metabolic acidosis is addressed by the reduction of ketoacids production thereby returning her blood ph to normal and reducing the need for compensatory hyperventilation.

    • This question is part of the following fields:

      • Endocrine
      • Physiology
      13.4
      Seconds
  • Question 2 - A 30-year-old man suffers from an open fracture of his forearm. As a...

    Correct

    • A 30-year-old man suffers from an open fracture of his forearm. As a consequence of his injury, the nerve that innervates the pronator quadratus muscle was severed. Which of the following statements regarding the pronator quadratus muscle is considered correct?

      Your Answer: Its deep fibres bind the radius and ulna together

      Explanation:

      Pronator quadratus is a deep-seated, short, flat, and quadrilateral muscle with fibres running in a parallel direction. It arises from the oblique ridge on the anterior surface of the distal fourth of the Ulna. It is inserted in lateral border and anterior surface of the distal fourth of the radius. It is innervated by the anterior interosseous nerve, a branch of the median nerve (C8-T1). It is vascularized by the anterior interosseous artery.The action of the pronator quadratus muscle along with the pronator teres result in the pronation of the radioulnar joint. Contraction of this muscle pulls the distal end of the radius over the ulna, resulting in the pronation of the radioulnar joint

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      16.1
      Seconds
  • Question 3 - A 63-year-old man presents with severe abdominal pain and vomiting of blood. An...

    Correct

    • A 63-year-old man presents with severe abdominal pain and vomiting of blood. An endoscopy was performed and a peptic ulcer was found to have eroded into an artery nearby.Which of the following most likely describes the location of the ulcer?

      Your Answer: The posterior duodenum

      Explanation:

      The most common cause of upper gastrointestinal bleeding is peptic ulcer disease, particularly gastric and duodenal ulcers. Duodenal ulcers are most commonly associated with bleeding compared with gastric ulcers. Posterior duodenal ulcers are considered to be the most likely to cause severe bleeding because of its proximity to the branches of the gastroduodenal artery (GDA).

    • This question is part of the following fields:

      • Abdomen And Pelvis
      • Anatomy
      16.8
      Seconds
  • Question 4 - Antinuclear antibodies (ANAs) also referred to as anti-nuclear factors (ANFs) are autoantibodies that...

    Incorrect

    • Antinuclear antibodies (ANAs) also referred to as anti-nuclear factors (ANFs) are autoantibodies that bind to contents of the cell nucleus.Which ONE of these statements about ANAs is true?

      Your Answer: Anti-Ro antibodies are associated with CREST syndrome

      Correct Answer: They can be of any immunoglobulin class

      Explanation:

      Anti-nuclear antibodies(ANAs) also referred to as anti-nuclear factors (ANFs) are autoantibodies that bind to contents of the cell nucleus. They can be of any immunoglobulin class.CREST syndrome is usually associated with anti-centromere antibodies.ELISA testing is cheaper but not the most accurate means of testing for ANAs. Indirect immunofluorescence testing is the most reliable.Nucleolar staining is suggestive of scleroderma, while homogenous staining is suggestive of lupus.Anti-dsDNA antibodies are found in 80 – 90% of patients with SLE

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      38.1
      Seconds
  • Question 5 - Regarding Clostridium difficile, which of the following statements is CORRECT: ...

    Correct

    • Regarding Clostridium difficile, which of the following statements is CORRECT:

      Your Answer: It is normally found in gut flora.

      Explanation:

      C. difficile is normally found in the gut flora but its growth is normally suppressed by more dominant anaerobes. It has exotoxin-mediated effects causing profuse diarrhoea. Oral clindamycin (a broad spectrum antibiotic) is commonly implicated in precipitating C. difficile colitis; first line treatment is with oral metronidazole. Tetanolysin is a toxin produced by Clostridium tetani bacteria.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      75.5
      Seconds
  • Question 6 - Regarding gastric motility and emptying, which of the following statements is CORRECT: ...

    Incorrect

    • Regarding gastric motility and emptying, which of the following statements is CORRECT:

      Your Answer: A high pH in the duodenum inhibits gastric emptying.

      Correct Answer: Gastric emptying is inhibited by the presence of the products of fat digestion in the duodenum.

      Explanation:

      Gastric emptying is decreased by the presence of fats in the duodenum (by stimulating release of cholecystokinin). Mixing of the food with gastric secretions takes place in the distal body and antrum of the stomach where the muscularis externa layer is thicker. The stomach has an additional inner oblique smooth muscle layer (in addition to the inner circular layer and outer longitudinal layer). Gastric emptying is increased by a low gastric pH and decreased by a low duodenal pH.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      82.1
      Seconds
  • Question 7 - A 35-year-old man presents with haemoptysis, night sweats, and weight loss. Further examinations...

    Correct

    • A 35-year-old man presents with haemoptysis, night sweats, and weight loss. Further examinations were done and a diagnosis of tuberculosis is suspected. Which of the following statements is considered correct regarding Mycobacterium tuberculosis?

      Your Answer: It is impervious to decolourisation with acid

      Explanation:

      Mycobacterium tuberculosis are part of the Mycobacteriaceae family. They are described to have the characteristics of a Gram-positive cell wall but they are not easily stained with Gram stain. This is because their cell wall contains a high lipid content, and this lipid allows the Mycobacteria to bind to alkaline stains with the application and help of heat. Once stained, they are able to resist decolorization even with the use of acid alcohol as the decolourizer, making them very difficult to decolorize, that is why they are known to be acid-fast.The Ghon complex is a non-pathognomonic radiographic finding on a chest x-ray that is significant for pulmonary infection of tuberculosis. The location of the Ghon’s focus is usually subpleural and predominantly in the upper part of the lower lobe and lower part of the middle or upper lobe. Skeletal tuberculosis of the spine is referred to as Pott disease.The risk of reactivation TB is about 3.3% during the first year after a positive PPD skin test and a total of 5% to 15% thereafter in the person’s lifetime. Progression from infection to active disease varies with age and the intensity and duration of exposure. Reactivation TB occurs when there is an alteration or suppression of the cellular immune system in the infected host that favoursreplication of the bacilli and progression to disease.

    • This question is part of the following fields:

      • Microbiology
      • Specific Pathogen Groups
      53.3
      Seconds
  • Question 8 - You examine a child who has been admitted to the paediatric emergency department...

    Correct

    • You examine a child who has been admitted to the paediatric emergency department with a flu-like illness. His parents tell you that he was born with an inborn defect of steroid metabolism and that he was treated for it with hormone replacement therapy.Which of the following is classified as a steroid hormone?

      Your Answer: Aldosterone

      Explanation:

      Hormones can be classified into three categories depending on their chemical composition: amines, peptides (and proteins), and steroids. Amines are made up of single amino acids (for example, tyrosine), peptide hormones are made up of peptides (or proteins), and steroid hormones are made up of cholesterol.The table below lists some prominent instances of each of these three hormone classes:1. Peptide hormone: Adrenocorticotropic hormone (ACTH)Prolactin VasopressinOxytocin GlucagonInsulin SomatostatinCholecystokinin 2. Amine hormone:Adrenaline (epinephrine) Noradrenaline (norepinephrine)Dopamine3. Steroid hormone:Mineralocorticoids (e.g. aldosterone)Glucocorticoids (e.g. cortisol)ProgestogensAndrogensOestrogens

    • This question is part of the following fields:

      • Endocrine Physiology
      • Physiology
      22.8
      Seconds
  • Question 9 - Which of the following statements regarding hookworm is FALSE: ...

    Incorrect

    • Which of the following statements regarding hookworm is FALSE:

      Your Answer: Diagnosis is by direct visualisation of characteristic eggs in stool on microscopy.

      Correct Answer: Transmission of hookworm is via ingestion of contaminated food and water.

      Explanation:

      The hookworm life cycle begins with the passage of eggs from an adult host into the stool. Hookworm eggs hatch in the soil to release larvae that mature into infective larvae. Infection is usually transmitted by larval penetration into human skin (duodenal infection may also be transmitted by the oral route). From the skin, larvae migrate into the blood vessels and are carried to the lungs, where they penetrate the pulmonary alveoli, ascend the bronchial tree to the pharynx, and are swallowed.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      88.7
      Seconds
  • Question 10 - A 26-year-old male presents to your clinic with the complaint of recurrent fevers...

    Incorrect

    • A 26-year-old male presents to your clinic with the complaint of recurrent fevers over the past three months. On documentation of the fever, it is noted that the fever increases and decreases in a cyclical pattern over a 1-2 week period. After the appropriate investigations, a diagnosis of Pel-Ebstein fever is made. Which ONE of the following conditions is most likely to cause this patient's fever?

      Your Answer: Glandular fever

      Correct Answer: Hodgkin lymphoma

      Explanation:

      The release of cytokines from Reed-Sternberg cells can cause fever in patients with Hodgkin lymphoma, which increases and decreases in a cyclical pattern of 1 to 2 weeks. This is called Pel-Ebstein or Ebstein-Cardarelli fever, specifically seen in Hodgkin lymphoma. The fever is always high grade and can reach 40 degrees or higher.Cyclical fever in other conditions is common but is not termed as Pel-Ebstein fever. This term is reserved only with Hodgkin lymphoma.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      227.4
      Seconds
  • Question 11 - Regarding carbohydrate, which of the following statements is INCORRECT: ...

    Correct

    • Regarding carbohydrate, which of the following statements is INCORRECT:

      Your Answer: Most dietary carbohydrate is in the form of disaccharides.

      Explanation:

      Carbohydrates are the main energy source of most diets. They provide 17 kJ (4 kcal) of energy per gram. Most dietary carbohydrate is in the form of polysaccharides. The principal ingested polysaccharides are starch which is derived from plant sources and glycogen which is derived from animal sources. Dietary fibre consists of indigestible carbohydrate (found in plant foods) such as cellulose, lignin and pectin.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      29.8
      Seconds
  • Question 12 - What is nimodipine used predominantly in the treatment of? ...

    Incorrect

    • What is nimodipine used predominantly in the treatment of?

      Your Answer: Refractory angina

      Correct Answer: Prevention and treatment of vascular spasm following subarachnoid haemorrhage

      Explanation:

      Nimodipine is a smooth muscle relaxant that is related to nifedipine, but the effects preferentially act on cerebral arteries. It is exclusively used for the prevention and treatment of vascular spasm after an aneurysmal subarachnoid haemorrhage.

    • This question is part of the following fields:

      • Cardiovascular
      • Pharmacology
      14.8
      Seconds
  • Question 13 - A tumour compresses the jugular foramen of a 50-year-old patient. Compression of several...

    Correct

    • A tumour compresses the jugular foramen of a 50-year-old patient. Compression of several nerves in the jugular foramen will result in which of the following complications?

      Your Answer: Loss of gag reflex

      Explanation:

      The glossopharyngeal nerve, which is responsible for the afferent pathway of the gag reflex, the vagus nerve, which is responsible for the efferent pathway of the gag reflex, and the spinal accessory nerve all exit the skull through the jugular foramen. These nerves are most frequently affected if the jugular foramen is compressed. As a result, the patient’s gag reflex is impaired. The vestibulocochlear nerve is primarily responsible for hearing. The trigeminal nerve provides sensation in the face. The facial nerve innervates the muscles of face expression (including those responsible for closing the eye). Tongue motions are controlled mostly by the hypoglossal nerve.

    • This question is part of the following fields:

      • Anatomy
      • Cranial Nerve Lesions
      7.3
      Seconds
  • Question 14 - An ambulance transports a 40-year-old man to the hospital. He ingested a significant...

    Correct

    • An ambulance transports a 40-year-old man to the hospital. He ingested a significant amount of aspirin.In the early stages of an aspirin overdose, which form of acid-base problem should you anticipate? 

      Your Answer: Respiratory alkalosis

      Explanation:

      When you take too much aspirin, you have a mix of respiratory alkalosis and metabolic acidosis. Respiratory centre stimulation produces hyperventilation and respiratory alkalosis in the early phases. The direct acid actions of aspirin tend to create a higher anion gap metabolic acidosis in the latter phases.Below summarizes some of the most common reasons of acid-base abnormalities:Respiratory alkalosis: – Hyperventilation (e.g. anxiety, pain, fever)- Pulmonary embolism- Pneumothorax- CNS disorders (e.g. CVA, SAH, encephalitis)- High altitude- Pregnancy- Early stages of aspirin overdoseRespiratory acidosis:- COPD- Life-threatening asthma- Pulmonary oedema- Respiratory depression (e.g. opiates, benzodiazepines)- Neuromuscular disease (e.g. Guillain-Barré syndrome, muscular dystrophy- Incorrect ventilator settings (hypoventilation)- ObesityMetabolic alkalosis:- Vomiting- Cardiac arrest- Multi-organ failure- Cystic fibrosis- Potassium depletion (e.g. diuretic usage)- Cushing’s syndrome- Conn’s syndromeMetabolic acidosis (with raised anion gap):- Lactic acidosis (e.g. hypoxaemia, shock, sepsis, infarction)- Ketoacidosis (e.g. diabetes, starvation, alcohol excess)- Renal failure- Poisoning (e.g. late stages of aspirin overdose, methanol, ethylene glycol)Metabolic acidosis (with normal anion gap):- Renal tubular acidosis- Diarrhoea- Ammonium chloride ingestion- Adrenal insufficiency

    • This question is part of the following fields:

      • Physiology
      • Renal Physiology
      99.9
      Seconds
  • Question 15 - During swallowing, which of the following structures primarily closes the tracheal opening: ...

    Correct

    • During swallowing, which of the following structures primarily closes the tracheal opening:

      Your Answer: Epiglottis

      Explanation:

      The vocal cords of the larynx are stronglyapproximated, and the larynx is pulled upwardand anteriorly by the neck muscles. These actions,combined with the presence of ligaments thatprevent upward movement of the epiglottis, causethe epiglottis to swing back over the openingof the larynx. All these effects acting togetherprevent the passage of food into the nose andtrachea. Most essential is the tight approximationof the vocal cords, but the epiglottis helps toprevent food from ever getting as far as the vocalcords. Destruction of the vocal cords or of themuscles that approximate them can causestrangulation.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      17.5
      Seconds
  • Question 16 - Which of the following factors decreases insulin secretion: ...

    Correct

    • Which of the following factors decreases insulin secretion:

      Your Answer: Catecholamines

      Explanation:

      Factors that increase insulin secretion:↑ Blood glucose↑ Amino acids↑ Fatty acidsGlucagonSecretinAcetylcholineFactors that decrease insulin secretion:↓ Blood glucoseSomatostatinCatecholamines

    • This question is part of the following fields:

      • Endocrine
      • Physiology
      11.1
      Seconds
  • Question 17 - Reed-Sternberg cells are characteristic of which of the following malignancies: ...

    Correct

    • Reed-Sternberg cells are characteristic of which of the following malignancies:

      Your Answer: Hodgkin lymphoma

      Explanation:

      Lymphomas are a group of diseases caused by malignant lymphocytes that accumulate in lymph nodes and other lymphoid tissue and cause the characteristic clinical feature of lymphadenopathy. The major subdivision of lymphomas is into Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) and this is based on the histological presence of Reed-Sternberg cells present in HL. Hodgkin lymphoma can present at any age but is rare in children and has a peak incidence in young adults. There is an almost 2 : 1 male predominance. Most patients present with painless, asymmetrical, firm and discrete enlargement of superficial lymph nodes. Cervical nodes are involved in 60-70% of cases, axillary nodes in 10-15% and inguinal nodes in 6-12%. Modest splenomegaly occurs during the course of the disease in 50% of patients; the liver may also be enlarged. Bone marrow failure involvement is unusual in early disease. The prognosis depends on age, stage and histology, but overall approximately 85% of patients are cured. Alcohol‐induced pain and pruritus are two well‐known but rare symptoms in HL.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      38
      Seconds
  • Question 18 - An 8-year-old boy was brought to the emergency room with complaints of a...

    Correct

    • An 8-year-old boy was brought to the emergency room with complaints of a rash and fever that have been present for the past 3 days. Upon history taking and observation, it was noted that the rash started behind the ears and then spread to the face and body. The presence of coryzal symptoms, dry cough, and conjunctivitis was also observed.What is most likely the diagnosis of the case presented above?

      Your Answer: Measles

      Explanation:

      The measles virus is an enveloped virus classified in the genusMorbillivirus.Measles is highly contagious and spreads by aerosol. Initial replication takes place in the mucosal cells of the respiratory tract; measles virus then replicates in the local lymph nodes and spreads systemically. The virus circulates in the T and B cells and monocytes, until eventually the lungs, gut, bile duct, bladder, skin, and lymphatic organs are involved. After an incubation period of 7 to 10 days, there is an abrupt onset, with symptoms of sneezing, runny nose and cough, red eyes, and rapidly rising fever. About 2 to 3 days later, a maculopapular rash appears on the head and trunk. Koplik spots, lesions on the oral mucosa consisting of irregular red spots, with a bluish white speck in the centre, generally appear 2 to 3 days before the rash and are diagnostic.Measles is easily diagnosed clinically, so few requests for laboratory identification are made. The virus is fragile and must be handled carefully. The specimens of choice are from the nasopharynx and urine, but the virus can only be recovered from these sources in the early stages of infection. The virus grows on PMK cells, causing the formation of distinctive spindle-shaped or multinucleated cells.

    • This question is part of the following fields:

      • Microbiology
      • Specific Pathogen Groups
      40.6
      Seconds
  • Question 19 - Regarding dermatophytes, which of the following statement is CORRECT: ...

    Correct

    • Regarding dermatophytes, which of the following statement is CORRECT:

      Your Answer: Diagnosis is made from microscopy and culture of skin scrapings, hair samples or nail clippings.

      Explanation:

      Diagnosis is made from microscopy and culture of skin scrapings, hair samples or nail clippings depending on the site of infection. The lesions of ringworm typically have a dark outer ring with a pale centre. Tinea capitis is ringworm affecting the head and scalp. Spread is via direct skin contact. Treatment is usually topical, oral antifungals are reserved for refractory infection.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      125
      Seconds
  • Question 20 - Which of the following nerves provides sensory innervation to the anteromedial and anterosuperior...

    Correct

    • Which of the following nerves provides sensory innervation to the anteromedial and anterosuperior aspects of the external ear?

      Your Answer: Auriculotemporal nerve

      Explanation:

      Sensory innervation to the external ear is supplied by both cranial and spinal nerves. Branches of the trigeminal, facial, and vagus nerves (CN V, VII, X) are the cranial nerve components, while the lesser occipital (C2, C3) and greater auricular (C2, C3) nerves are the spinal nerve components involved. The lateral surface of the tympanic membrane, the external auditory canal, and the external acoustic meatus are all innervated by nervus intermedius (a branch of CN VII), the auriculotemporal nerve (CN V3), and the auricular branch of the vagus nerve. The concha receives split innervation from nervus intermedius, the auricular branch of the vagus nerve, and the greater auricular (spinal) nerve. Beyond the concha, the anteromedial and anterosuperior parts of the pinna are innervated by the auriculotemporal nerve, and a portion of the lateral helix by the lesser occipital nerve. The greater auricular nerve provides innervation to the area of the pinna inferolateral to the lobule.

    • This question is part of the following fields:

      • Anatomy
      • Head And Neck
      28.6
      Seconds
  • Question 21 - A patient noticed ankle swelling and has passed very little urine over the...

    Incorrect

    • A patient noticed ankle swelling and has passed very little urine over the past 24 hours. He also has nausea and vomiting, reduced urine output and his blood results reveal a sudden rise in his creatinine levels over the past 48 hours. You make a diagnosis of acute kidney injury (AKI).Which one of these is a prerenal cause of AKI?

      Your Answer: Eclampsia

      Correct Answer: Cardiac failure

      Explanation:

      The causes of AKI can be divided into pre-renal, intrinsic renal and post-renal causes. Majority of AKI developing in the community is due to a pre-renal causes (90% of cases).Pre-renal causes: Haemorrhage, severe vomiting or diarrhoea, burns, cardiac failure, liver cirrhosis, nephrotic syndrome, hypotension, severe cardiac failure, NSAIDs, COX-2 inhibitors, ACE inhibitors or ARBs, Abdominal aortic aneurysm, renal artery stenosis, hepatorenal syndrome, Intrinsic (renal) causes:Eclampsia, glomerulonephritis, thrombosis, haemolytic-uraemic syndrome, acute tubular necrosis (ATN), acute interstitial nephritis, drugs ( NSAIDs), infection or autoimmune diseases, vasculitis, polyarteritis nodosa, thrombotic microangiopathy, cholesterol emboli, renal vein thrombosis, malignant hypertensionPost-renal causes: Renal stones, Blood clot, Papillary necrosis, Urethral stricture, Prostatic hypertrophy or malignancy, Bladder tumour, Radiation fibrosis, Pelvic malignancy, Retroperitoneal fibrosis

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      231.3
      Seconds
  • Question 22 - The weight distribution in a group of patients included in a study was...

    Incorrect

    • The weight distribution in a group of patients included in a study was normal. The patients averaged 80 kg in weight. 5 kg was determined to be the standard deviation. Which of the following statements most accurately describes this group of patients:

      Your Answer: 95% of the patients will weigh between 75 and 85 kg.

      Correct Answer: 68% of the patients will weigh between 75 and 85 kg.

      Explanation:

      We can estimate the range of values that would be anticipated to include particular proportions of observations if we know the mean and standard deviation of a collection of normally distributed data: 68.2 percent of the sample results fall within a one SD range above and below the mean (+/- 1 SD), implying that 68 percent of the patients will weigh between 75 and 85 kg. Because +/- 2 SD encompasses 95.4 percent of the data, around 95 percent of the patients will weigh between 70 and 90 kg. +/- 3 SD encompasses 99.7% of the values, implying that nearly all of the patients will weigh between 65 and 95 kg.

    • This question is part of the following fields:

      • Evidence Based Medicine
      • Statistics
      26.7
      Seconds
  • Question 23 - A 20-year-old male has an anaphylactic reaction following a wasp sting.What type of...

    Correct

    • A 20-year-old male has an anaphylactic reaction following a wasp sting.What type of hypersensitivity reaction is this?

      Your Answer: Type I

      Explanation:

      Anaphylaxis is an example of a type I hypersensitivity reaction. It is IgE mediated. It requires a prior exposure to the antigen. The initial exposure sensitizes the body to the antigen and a second exposure to that antigen leads to an anaphylactic reaction.Massive calcium influx into the cells leads to mast cell degranulation. The Immunoglobulin antigen complex binds to Fc receptors on the surface of mast cells. The result is mast cell degranulation and release of histamine, proteoglycans and serum proteases from cytoplasmic granules.

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      4.9
      Seconds
  • Question 24 - Regarding Campylobacter gastroenteritis, which of the following statements is INCORRECT: ...

    Correct

    • Regarding Campylobacter gastroenteritis, which of the following statements is INCORRECT:

      Your Answer: Infection usually requires antibiotic treatment.

      Explanation:

      Campylobacter jejuni is the primary human pathogen, typically causing dysentery (bloody diarrhoea illness) following ingestion of contaminated meat, especially poultry. Infection is typically self-limiting and does not require antibiotic therapy. Campylobacter gastroenteritis is associated with the immune-mediated complications of Guillain-Barre syndrome, reactive arthritis and Reiter’s syndrome.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      94.9
      Seconds
  • Question 25 - A 50-year-old man, known hypertensive on amlodipine has been visiting his GP with...

    Incorrect

    • A 50-year-old man, known hypertensive on amlodipine has been visiting his GP with symptoms of headache, tiredness, and muscle weakness. His blood test today shows a low potassium level of 2.8 mmol/L, and a slightly raised sodium level at 147 mmol/L.What is the MOST LIKELY diagnosis?

      Your Answer: Cushing’s syndrome

      Correct Answer: Conn’s syndrome

      Explanation:

      When there are excessive levels of aldosterone independent of the renin-angiotensin aldosterone axis, primary hyperaldosteronism occurs. Secondary hyperaldosteronism occurs due to high renin levels.Causes of primary hyperaldosteronism include:Conn’s syndromeAdrenal hyperplasiaAdrenal cancerFamilial aldosteronismCauses of secondary hyperaldosteronism include:Renal vasoconstrictionOedematous disordersDrugs – diureticsObstructive renal artery diseaseAlthough patients are usually asymptomatic, when clinical features are present, classically hyperaldosteronism presents with:HypokalaemiaSodium levels can be normal or slightly raisedHypertensionMetabolic alkalosisLess common, clinical features are:LethargyHeadachesIntermittent paraesthesiaPolyuria and polydipsiaMuscle weakness (from persistent hypokalaemia)Tetany and paralysis (rare)

    • This question is part of the following fields:

      • Endocrine Physiology
      • Physiology
      31.8
      Seconds
  • Question 26 - All of the following are physiological effects of thyroid hormones except: ...

    Correct

    • All of the following are physiological effects of thyroid hormones except:

      Your Answer: Increased glycogenesis

      Explanation:

      Thyroid hormones have multiple physiological effects on the body. These include:1. Heat production (thermogenesis)2. Increased basal metabolic rate3. Metabolic effects: (a) Increase in protein turnover (both synthesis and degradation are increased, although overall effect is catabolic)(b) Increase in lipolysis(c)Increase in glycogenolysis and gluconeogenesis4. Enhanced catecholamine effect – Increase in heart rate, stroke volume and thus cardiac output5. Important role in growth and development

    • This question is part of the following fields:

      • Endocrine
      • Physiology
      39.9
      Seconds
  • Question 27 - A 27-year-old athlete presents with buttock pain after tearing his gluteus maximus muscle.In...

    Correct

    • A 27-year-old athlete presents with buttock pain after tearing his gluteus maximus muscle.In which of the following nerves is the gluteus maximus muscle innervated by?

      Your Answer: Inferior gluteal nerve

      Explanation:

      The gluteal muscles are a group of muscles that make up the buttock area. These muscles include: gluteus maximus, gluteus medius. and gluteus minimus.The gluteus maximus is the most superficial as well as largest of the three muscles and makes up most of the shape and form of the buttock and hip area. It is a thick, fleshy muscle with a quadrangular shape. It is a large muscle and plays a prominent role in the maintenance of keeping the upper body erect.The innervation of the gluteus maximus muscle is from the inferior gluteal nerve.

    • This question is part of the following fields:

      • Anatomy
      • Lower Limb
      77.8
      Seconds
  • Question 28 - Foetal haemoglobin (HbF) comprises about how much of the total haemoglobin in adults:...

    Correct

    • Foetal haemoglobin (HbF) comprises about how much of the total haemoglobin in adults:

      Your Answer: 0.5 - 0.8%

      Explanation:

      Foetal haemoglobin (HbF) makes up about 0.5 – 0.8 % of total adult haemoglobin and consists of two α and two gamma (γ) globin chains.

    • This question is part of the following fields:

      • Basic Cellular
      • Physiology
      10.8
      Seconds
  • Question 29 - Which of these immunoglobulin molecules can cross the placenta? ...

    Incorrect

    • Which of these immunoglobulin molecules can cross the placenta?

      Your Answer: IgM

      Correct Answer: IgG

      Explanation:

      An important mechanism that provides protection to the foetus is placental transfer of maternal IgG antibodies while his/her humoral response is inefficient. The only antibody class that significantly crosses the human placenta is IgG.

    • This question is part of the following fields:

      • Immune Responses
      • Pathology
      53.1
      Seconds
  • Question 30 - A 46-year-old male who is suffering from a chest infection. You decide to start giving...

    Correct

    • A 46-year-old male who is suffering from a chest infection. You decide to start giving the patient antibiotics, however he is allergic to penicillin. You consult with one of your co-workers about the best choice of antibiotic to give. From the following choices, which is considered an example of bacteriostatic antibiotic?

      Your Answer: Trimethoprim

      Explanation:

      Antibiotics that are bactericidal kill bacteria, while antibiotics that are bacteriostatic limit their growth or reproduction. The antibiotics grouped into these two classes are summarized in the table below:Bactericidal antibioticsBacteriostatic antibioticsVancomycinMetronidazoleFluoroquinolone, such as ciprofloxacinPenicillins, such as benzylpenicillinCephalosporin, such as ceftriaxoneCo-trimoxazoleTetracyclines, such as doxycyclineMacrolides, such as erythromycinSulphonamides, such as sulfamethoxazoleClindamycinTrimethoprimChloramphenicol

    • This question is part of the following fields:

      • Infections
      • Pharmacology
      80.8
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

Endocrine (3/3) 100%
Physiology (8/10) 80%
Anatomy (5/5) 100%
Upper Limb (1/1) 100%
Abdomen And Pelvis (1/1) 100%
General Pathology (1/3) 33%
Pathology (2/6) 33%
Microbiology (5/6) 83%
Pathogens (3/4) 75%
Gastrointestinal (2/3) 67%
Specific Pathogen Groups (2/2) 100%
Endocrine Physiology (1/2) 50%
Haematology (1/2) 50%
Cardiovascular (0/1) 0%
Pharmacology (1/2) 50%
Cranial Nerve Lesions (1/1) 100%
Renal Physiology (1/1) 100%
Head And Neck (1/1) 100%
Evidence Based Medicine (0/1) 0%
Statistics (0/1) 0%
Lower Limb (1/1) 100%
Basic Cellular (1/1) 100%
Immune Responses (0/1) 0%
Infections (1/1) 100%
Passmed