00
Correct
00
Incorrect
00 : 00 : 00
Session Time
00 : 00
Average Question Time ( Mins)
  • Question 1 - The patient is a 66-year-old woman who has troublesome bilateral ankle swelling. This...

    Correct

    • The patient is a 66-year-old woman who has troublesome bilateral ankle swelling. This has been happening since she began taking a new antihypertensive medication a few weeks ago.Which of the following medications is most likely to be the cause of this adverse reaction?

      Your Answer: Amlodipine

      Explanation:

      Amlodipine is a calcium-channel blocker that is frequently used to treat hypertension. Ankle swelling is a very common side effect of calcium-channel blockers, and it occurs quite frequently.

    • This question is part of the following fields:

      • Cardiovascular Pharmacology
      • Pharmacology
      15.5
      Seconds
  • Question 2 - Which of the following is the correct sequential order of the phases of...

    Correct

    • Which of the following is the correct sequential order of the phases of healing:

      Your Answer: Haemostasis, inflammation, proliferation, remodelling

      Explanation:

      Acute wound healing has four main stages: haemostasis, inflammation, proliferation and remodelling.

    • This question is part of the following fields:

      • Pathology
      • Wound Healing
      7.2
      Seconds
  • Question 3 - Which of the following is most likely affected in De Quervain's tenosynovitis? ...

    Incorrect

    • Which of the following is most likely affected in De Quervain's tenosynovitis?

      Your Answer: Adductor pollicis

      Correct Answer: Extensor pollicis brevis

      Explanation:

      De Quervain tenosynovitis is named after the Swiss surgeon, Fritz de Quervain, who first described it in 1895. It is a condition which involves tendon entrapment affecting the first dorsal compartment of the wrist. With this condition thickening of the tendon sheaths around the abductor pollicis longus and extensor pollicis brevis develops where the tendons pass in through the fibro-osseous tunnel located along the radial styloid at the distal wrist. Pain is exacerbated by thumb movement and radial and ulnar deviation of the wrist.The estimated prevalence of de Quervain tenosynovitis is about 0.5% in men and 1.3% in women with peak prevalence among those in their forties and fifties. It may be seen more commonly in individuals with a history of medial or lateral epicondylitis. Bilateral involvement is often reported in new mothers or child care providers in whom spontaneous resolution typically occurs once lifting of the child is less frequent.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      39.9
      Seconds
  • Question 4 - Which of the following nerves is most important for eversion of the foot:...

    Incorrect

    • Which of the following nerves is most important for eversion of the foot:

      Your Answer: Tibial nerve

      Correct Answer: Superficial fibular nerve

      Explanation:

      Eversion of the foot is primarily produced by the fibularis longus and fibularis brevis, both innervated by the superficial fibular nerve. The fibularis tertius, innervated by the deep fibular nerve, also assists in this action.

    • This question is part of the following fields:

      • Anatomy
      • Lower Limb
      12.3
      Seconds
  • Question 5 - A 40-year-old woman presents with a red, scaly, itchy rash around her navel...

    Correct

    • A 40-year-old woman presents with a red, scaly, itchy rash around her navel that occurred after contact with a nickel belt buckle. A diagnosis of allergic contact dermatitis is made.Which type of hypersensitivity reaction is this?

      Your Answer: Type IV hypersensitivity reaction

      Explanation:

      A type IV hypersensitivity reaction occurred in this patient. Allergic contact dermatitis is an inflammatory skin reaction occurring in response to an external stimulus, acting either as an allergen or an irritant, caused by a type IV or delayed hypersensitivity reaction. They usually take several days to develop.

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      7.6
      Seconds
  • Question 6 - A somatostatinoma is diagnosed in a 74-year-old patient who has recently developed diabetes...

    Correct

    • A somatostatinoma is diagnosed in a 74-year-old patient who has recently developed diabetes mellitus, recurrent episodes of gallstones, and Steatorrhoea. She also  has a tumour in the head of her pancreas.Which of the following is the most likely effect of this tumour? 

      Your Answer: Inhibit gastric acid secretion

      Explanation:

      Somatostatin-producing cells present in the pyloric antrum, duodenum, and pancreatic islets are known as D-cells or delta-cells. Somatostatin inhibits gastric acid secretion by acting directly on acid-producing parietal cells in the stomach via a G-protein coupled receptor.Somatostatin affects hormones in the following ways:Inhibits the anterior pituitary’s secretion of growth hormone.Inhibits the anterior pituitary’s secretion of thyroid-stimulating hormone.The secretion of various gastrointestinal hormones is inhibited (including gastrin, CCK, secretin, motilin, VIP and GIP) Reduces the rate at which the stomach empties.Inhibits the release of insulin and glucagon from the pancreas.The pancreas’ exocrine secretory activity is inhibited.Somatostatin can also slow the digestive process by suppressing the production of hormones such gastrin, secretin, and histamine, which reduces gastric acid secretion.A somatostatinoma is a cancerous tumour of the endocrine pancreas’ D-cells, which make somatostatin. Somatostatin inhibits pancreatic and gastrointestinal hormones when levels are high. The following clinical characteristics are related with somatostatinomas:Insulin secretion blockage causes diabetes mellitus.Gallstones by inhibition of CCK and secretin Steatorrhoea via inhibition of CCK and secretinHypochlorhydria is caused by the suppression of gastrin, a hormone that increases gastric acid output regularly.

    • This question is part of the following fields:

      • Gastrointestinal Physiology
      • Physiology
      82.5
      Seconds
  • Question 7 - A 69-year-old man presents with a painful groin swelling on the right side....

    Correct

    • A 69-year-old man presents with a painful groin swelling on the right side. The suspected diagnosis is an inguinal hernia.Which of the following examination features make it more likely to be an indirect inguinal hernia?

      Your Answer: It can be controlled by pressure over the deep inguinal ring

      Explanation:

      The reduced indirect inguinal hernia can be controlled by pressure over the internal ring; a direct inguinal hernia cannot.An indirect inguinal hernia can be reduced superiorly then superolaterally, while a direct inguinal hernia can be reduced superiorly then posteriorly.An indirect inguinal hernia takes time to reach full size, but a direct inguinal hernia appears immediately upon standing.Indirect inguinal hernias are seen as elliptical swelling, while direct inguinal hernias appear as symmetric, circular swelling.

    • This question is part of the following fields:

      • Abdomen And Pelvis
      • Anatomy
      20.3
      Seconds
  • Question 8 - A 57-year-old male presents to the orthopaedic clinic complaining of pain and swelling...

    Incorrect

    • A 57-year-old male presents to the orthopaedic clinic complaining of pain and swelling in the left knee joint. On examination, the left knee is swollen, tender and erythematous. The patient is booked for joint aspiration, and a diagnosis of pseudogout is made following the aspiration. Which types of crystals would be seen in the joint aspirate to lead to this diagnosis?

      Your Answer: Negatively birefringent needle-shaped crystals

      Correct Answer: Positively birefringent brick-shaped crystals

      Explanation:

      Gout and pseudogout are both characterised by crystal deposition in the affected joints. The deposition of urate crystals causes gout, while calcium pyrophosphate crystals cause pseudogout. The crystals can be distinguished microscopically because urate crystals are negatively birefringent needle-shaped crystals, whilst calcium pyrophosphate crystals are positively birefringent brick-shaped crystals.

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      224.6
      Seconds
  • Question 9 - An analytical cohort study is done to compare the relationship between omega 3...

    Incorrect

    • An analytical cohort study is done to compare the relationship between omega 3 intake and occurrence of myocardial infarction (MI) among males aged over 65 years. The following are the data from the study:No. of subjects taking placebo: 100 menNo. of subjects taking placebo who suffered an MI: 15 menNo. of subjects taking omega 3: 100 menNo. of subjects taking omega 3 who suffered an MI: 5 menCompute for the absolute risk in the treatment (omega 3) group.

      Your Answer: 0.2

      Correct Answer: 0.05

      Explanation:

      The absolute risk (AR) is the probability or chance of an event. It is computed as the number of events in treated or control groups, divided by the number of people in that group.AR = 5/100 = 0.05

    • This question is part of the following fields:

      • Evidence Based Medicine
      112.2
      Seconds
  • Question 10 - A 34-year-old man arrives at the department befuddled. He has a history of...

    Correct

    • A 34-year-old man arrives at the department befuddled. He has a history of schizophrenia and is on an antipsychotic medication, but he can't recall what it's called.Which of the following statements about antipsychotic drug side effects is correct?

      Your Answer: Haloperidol is the most common causative antipsychotic drug

      Explanation:

      Extrapyramidal side effects are most common with piperazine phenothiazines (fluphenazine, prochlorperazine, and trifluoperazine) and butyrophenones (fluphenazine, prochlorperazine, and trifluoperazine) (benperidol and haloperidol). The most common causative antipsychotic drug is haloperidol.Tardive dyskinesia (rhythmic, involuntary movements of the tongue, face, and jaw) is most commonly associated with long-term or high-dose treatment. It is the most serious form of extrapyramidal symptoms because withdrawal of the causative drug may make it irreversible, and treatment is usually ineffective.Dystonia (abnormal facial and body movements) is more common in children and young adults, and it usually shows up after only a few doses. Procyclidine 5 mg IV or benzatropine 2 mg IV as a bolus can be used to treat acute dystonia.An unpleasant feeling of restlessness characterises akathisia. The inability to initiate movement is known as akinesia.Renal impairment causes increased cerebral sensitivity, so lower doses should be used.In elderly patients with dementia-related psychosis who are treated with haloperidol, there is an increased risk of death. This appears to be due to a higher risk of heart attacks and infections like pneumonia.The following are some of the antipsychotic drugs’ contraindications:Reduced level of consciousness/comaDepression of the central nervous systemPhaeochromocytoma

    • This question is part of the following fields:

      • CNS Pharmacology
      • Pharmacology
      9
      Seconds
  • Question 11 - A patient was diagnosed with Erb's palsy as a result of a brachial...

    Incorrect

    • A patient was diagnosed with Erb's palsy as a result of a brachial plexus injury sustained in a car accident and, as a result, suffers from left arm paralysis. The following muscles are affected by the injury, except

      Your Answer: Infraspinatus

      Correct Answer: Trapezius

      Explanation:

      Damage to the C5 and C6 nerve roots causes Erb’s palsy. The spinal accessory nerve (CN XI) innervates the trapezius muscle, thus you would not expect this muscle to be impacted. The trapezius is a muscle that runs from the base of the neck across the shoulders and into the centre of the back.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      21.4
      Seconds
  • Question 12 - Giemsa-stained blood film microscopy is typically used for the diagnosis of which of...

    Incorrect

    • Giemsa-stained blood film microscopy is typically used for the diagnosis of which of the following:

      Your Answer: Syphilis

      Correct Answer: Malaria

      Explanation:

      Giemsa-stained blood film microscopy can be used to identify malarial parasites.

    • This question is part of the following fields:

      • Microbiology
      • Principles
      62.8
      Seconds
  • Question 13 - Regarding Gaussian sample distribution, which of the following statements is false? ...

    Incorrect

    • Regarding Gaussian sample distribution, which of the following statements is false?

      Your Answer: The median is the middle point of the observations

      Correct Answer: It can be skewed left or right

      Explanation:

      Gaussian distribution, also known as normal distribution, is the most important probability distribution in statistics because it fits many natural phenomena. The normal distribution is a probability function that describes how the values of a variable are distributed. Below are its characteristics:(1) Bell-shaped and symmetrical about the mean(2) The mean, median, mode are all equal(3) The total area under the curve and above the x-axis is equal to 1(4) It has long tapering tails extending infinitely but never touching the x-axis(5) It is determined by its parameters: its mean and standard deviation(6) The standard deviation becomes a more meaningful quality than merely being a measure of dispersionThe mean is the most common measure of central tendency. It is the sum of all observed values divided by the number of observation, and is also known as the ‘average’.The median is the value that falls in the middle position when the observations are ranked in order from the smallest to the largest. If the number of observations is odd, the median is the middle number. If it is even, the median is the average of the two middle numbers.The mode is the value that occurs with the greatest frequency in a set of observations, and is commonly used in public health statistics, such as the top 10 causes of mortality.

    • This question is part of the following fields:

      • Evidence Based Medicine
      100.3
      Seconds
  • Question 14 - An elderly patient presents to ED following a fall after feeling light headed...

    Correct

    • An elderly patient presents to ED following a fall after feeling light headed when standing up. You are reviewing his medication and note that he is taking a high dose of furosemide. Loop diuretics act primarily at which of the following sites in the nephron:

      Your Answer: Thick ascending limb

      Explanation:

      Loop diuretics inhibit the Na+/K+/2Cl- symporter on the luminal membrane in the thick ascending limb of the loop of Henle, thus preventing reabsorption of NaCl and water. These agents reduce reabsorption of Cl- and Na+ and increase Ca2+ excretion and loss of K+ and Mg2+.

    • This question is part of the following fields:

      • Cardiovascular
      • Pharmacology
      10.1
      Seconds
  • Question 15 - Regarding the factor V Leiden gene mutation, which of the following best describes...

    Correct

    • Regarding the factor V Leiden gene mutation, which of the following best describes the clinical effect:

      Your Answer: It results in increased levels of activated factor V.

      Explanation:

      Factor V Leiden gene mutation is the most common inherited cause of an increased risk of venous thrombosis. Activated protein C normally breaks down activated factor V and so should slow the clotting reaction and prolong the APTT, but a mutation in the factor V gene makes factor V less susceptible to cleavage by activated protein C, resulting in increased levels of activated factor V.Heterozygotes for factor V Leiden are at an approximately five- to eight- fold increased risk of venous thrombosis compared to the general population (but only 10% of carriers will develop thrombosis in their lifetime). Homozygotes have a 30 – 140-fold increased risk. The incidence of factor V Leiden in patients with venous thrombosis is approximately 20 – 40%. It does not increase the risk of arterial thrombosis.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      18
      Seconds
  • Question 16 - A 53-year-old man arrives at the emergency department complaining of visual impairment in...

    Correct

    • A 53-year-old man arrives at the emergency department complaining of visual impairment in his right eye. On examination, you notice that neither his right nor left pupil constricts when you shine a light in his right eye. When you flash a light in his left eye, the pupils of both his left and right eyes constrict. Which of the following nerves is the most likely to be affected:

      Your Answer: Optic nerve

      Explanation:

      In full optic nerve palsy, the afferent pupillary light reflex is lost. Because the afferent optic nerve does not sense light flashed in the afflicted eye, the ipsilateral direct and contralateral consensual reflexes are gone. However, the contralateral direct and ipsilateral consensual reflexes are intact because the efferent oculomotor nerve is normal.

    • This question is part of the following fields:

      • Anatomy
      • Cranial Nerve Lesions
      75.3
      Seconds
  • Question 17 - A 20-year-old with type I diabetes mellitus has an episode of hypoglycaemia following...

    Incorrect

    • A 20-year-old with type I diabetes mellitus has an episode of hypoglycaemia following inadvertent administration of too much insulin.The mechanism by which insulin causes glucose to be transported into cells is?

      Your Answer: Co-transport

      Correct Answer: Facilitated diffusion

      Explanation:

      The only mechanism by which insulin facilitates uptake of glucose into cells is by facilitated diffusion through a family of hexose transporters.The major transporter used for glucose uptake is GLUT4. GLUT4 is made available in the plasma membrane by the action of insulin.When insulin concentrations are low, GLUT4 transporters are present in cytoplasmic vesicles, where they are cannot be used for transporting glucose.

    • This question is part of the following fields:

      • Endocrine Physiology
      • Physiology
      40.2
      Seconds
  • Question 18 - Regarding the refractory period, which of the following statements is INCORRECT: ...

    Correct

    • Regarding the refractory period, which of the following statements is INCORRECT:

      Your Answer: Action potentials can occur in the relative refractory period but the amplitude of the action potential is smaller.

      Explanation:

      Following the action potential, Na+channels remain inactive for a time in a period known as the absolute refractory period where they cannot be opened by any amount of depolarisation. Following this there is a relative refractory period where the temporary hyperpolarisation (due to delayed closure of rectifier K+channels) makes the cell more difficult to depolarise and an action potential can be generated only in response to a larger than normal stimulus. The refractory period limits the frequency at which action potentials can be generated, and ensures that, once initiated, an action potential can travel only in one direction. An action potential is an all or nothing response so the amplitude of the action potential cannot be smaller.

    • This question is part of the following fields:

      • Basic Cellular
      • Physiology
      99.1
      Seconds
  • Question 19 - A 27-year-old athlete presents with buttock pain after tearing his gluteus maximus muscle.In...

    Correct

    • A 27-year-old athlete presents with buttock pain after tearing his gluteus maximus muscle.In which of the following nerves is the gluteus maximus muscle innervated by?

      Your Answer: Inferior gluteal nerve

      Explanation:

      The gluteal muscles are a group of muscles that make up the buttock area. These muscles include: gluteus maximus, gluteus medius. and gluteus minimus.The gluteus maximus is the most superficial as well as largest of the three muscles and makes up most of the shape and form of the buttock and hip area. It is a thick, fleshy muscle with a quadrangular shape. It is a large muscle and plays a prominent role in the maintenance of keeping the upper body erect.The innervation of the gluteus maximus muscle is from the inferior gluteal nerve.

    • This question is part of the following fields:

      • Anatomy
      • Lower Limb
      5.7
      Seconds
  • Question 20 - A blood culture was performed from a sample taken from a patient. It...

    Correct

    • A blood culture was performed from a sample taken from a patient. It was noted that a Gram-positive coccus organism was grown.Among the following microorganisms, which is considered an example of a Gram-positive coccus?

      Your Answer: Staphylococcus aureus

      Explanation:

      Bacillus cereus = Gram-positive bacillusNeisseria meningitidis = Gram-negative coccusSalmonella enterica & Escherichia coli = Gram-negative bacilliIn Gram staining, crystal violet is a purple stain that is used to stain the bacteria first. The stained bacteria are decolorized and then stained with a red stain, which is safranin. Bacteria with thick cell walls keep the purple stain and are called Gram-positive. Thin-walled bacteria are easily decolorized so when safranin, the red stain, is placed on the organisms, they become red or Gram-negative. The Staphylococci that are associated with infections in humans are colonizers of various skin and mucosal surfaces. Because the carrier state is common among the human population, infections are frequently acquired when the colonizing strain gains entrance to a normally sterile site as a result of trauma or abrasion to the skin or mucosal surface.

    • This question is part of the following fields:

      • Microbiology
      • Principles Of Microbiology
      8.1
      Seconds
  • Question 21 - Which of the following immunoglobulin molecules is the most abundant in secretions (such...

    Correct

    • Which of the following immunoglobulin molecules is the most abundant in secretions (such as saliva and breast milk):

      Your Answer: IgA

      Explanation:

      IgA is the predominant antibody class in secretions and tremendous quantities are secreted into various body spaces and onto mucosal surfaces (the gut lumen, the pharynx and sinuses, the larger airways, although not the alveoli). Because of its size, the majority of IgM is found in the circulation.Along with IgM, IgD is predominant among the surface receptors of mature B cells, where it plays a key role in B cells activation.IgE has the lowest concentration in normal human serum. It plays a prominent role in immune responses to helminth parasites, and in allergic reactions.IgG is the most abundant immunoglobulin and constitutes 75 percent of serum immunoglobulin in an adult human

    • This question is part of the following fields:

      • Immune Responses
      • Pathology
      19.6
      Seconds
  • Question 22 - A 32-year-old woman diagnosed with hyperthyroidism has her T 4 levels grossly elevated...

    Correct

    • A 32-year-old woman diagnosed with hyperthyroidism has her T 4 levels grossly elevated and she is started on carbimazole.A release of which of the following from the hypothalamus is inhibited by increase in T4 levels?

      Your Answer: Thyrotropin-releasing hormone

      Explanation:

      A negative feedback mechanism involving the hypothalamic-pituitary-thyroid axis controls the release of T3 and T4 into the bloodstream. When metabolic rate is low or serum T3 and/or T4 levels are decrease, this triggers the secretion of thyrotropin-releasing hormone (TRH) from the hypothalamus.TRH goes to the anterior pituitary gland and stimulates secretion of thyroid-stimulating hormone (TSH). An increased serum level of T3 and T4 inhibits the release of TRH.

    • This question is part of the following fields:

      • Endocrine Physiology
      • Physiology
      53.4
      Seconds
  • Question 23 - A 42-year-old patient with worsening epigastric pain has been referred to you by...

    Incorrect

    • A 42-year-old patient with worsening epigastric pain has been referred to you by a GP. The patient has been taking omeprazole for a month, but her symptoms are getting worse.Which of the following is NOT a well-known side effect of proton pump inhibitor treatment?

      Your Answer: Focal tachyarrhythmias

      Correct Answer: Pelvic fracture

      Explanation:

      Proton pump inhibitors (PPIs) have a variety of side effects, including:Vomiting and nauseaPain in the abdomenFlatulenceDiarrhoeaConstipationHeadachePPIs have been linked to a significant increase in the risk of focal tachyarrhythmias (link is external).Low serum magnesium and sodium levels have been linked to long-term use of PPIs, according to the US Food and Drug Administration (link is external).Long-term PPI use has also been linked to an increased risk of fracture, according to epidemiological evidence (link is external). Observational studies have discovered a slight link between hip, wrist, and spine fractures. However, there is no link between the two and an increased risk of pelvic fracture. For this reason, the MHRA recommends that patients at risk of osteoporosis who take PPIs maintain an adequate calcium and vitamin D intake.

    • This question is part of the following fields:

      • Gastrointestinal Pharmacology
      • Pharmacology
      46.6
      Seconds
  • Question 24 - Which of the following comprises a negative feedback mechanism? ...

    Correct

    • Which of the following comprises a negative feedback mechanism?

      Your Answer: Detectors, comparators, a variable set point and effectors

      Explanation:

      Negative feedback loops, also known as inhibitory loops, play a crucial role in controlling human health. It is a self-regulating mechanism of some sort. A negative feedback system is made up of three main components: a detector (often neural receptor cells) that measures the variable in question and provides input to the comparator; a comparator (usually a neural assembly in the central nervous system) that receives input from the detector, compares the variable to the variable set point, and determines whether or not a response is required. The comparator activates an effector (typically muscular or glandular tissue) to conduct the appropriate reaction to return the variable to its set point.

    • This question is part of the following fields:

      • Basic Cellular
      • Physiology
      98.4
      Seconds
  • Question 25 - Following a bee sting, a 12-year old boy was transported to resus with...

    Incorrect

    • Following a bee sting, a 12-year old boy was transported to resus with symptoms and signs of an anaphylactic reaction. You decide to administer adrenaline IM stat.What is the recommended dose of intramuscular adrenaline?

      Your Answer: 0.3 mL of 1:10000

      Correct Answer: 0.3 mL of 1:1000

      Explanation:

      Anaphylaxis is a type I hypersensitivity reaction that is severe and life-threatening. It is marked by the fast onset of life-threatening airway and/or circulatory issues, which are generally accompanied by skin and mucosal abnormalities. When an antigen attaches to specific IgE immunoglobulins on mast cells, degranulation and the release of inflammatory mediators takes place (e.g. histamine, prostaglandins, and leukotrienes).The most important medicine for treating anaphylactic responses is adrenaline. It decreases oedema and reverses peripheral vasodilation as an alpha-adrenergic receptor agonist. Its beta-adrenergic effects widen the bronchial airways, enhance the force of cardiac contraction, and inhibit the release of histamine and leukotriene. The first medicine to be given is adrenaline, and the IM route is optimal for most people.In anaphylaxis, age-related dosages of IM adrenaline are:150 mcg (0.15 mL of 1:1000) for a child under 6 years300 mcg (0.3 mL of 1:1000) for a child aged 6 to 12 years 500 mcg (0.5 mL of 1:1000) for children aged 12 and above 500 mcg for adults (0.5 mL of 1:1000)

    • This question is part of the following fields:

      • Pharmacology
      • Respiratory Pharmacology
      24.3
      Seconds
  • Question 26 - A 26-year-old female cuts her hand on a knife while preparing dinner but...

    Incorrect

    • A 26-year-old female cuts her hand on a knife while preparing dinner but the bleeding stops within a few minutes. Which one of the following cells will be among the first to be present at the wound site to be involved in haemostasis?

      Your Answer: Neutrophils

      Correct Answer: Platelets

      Explanation:

      Platelets are the first cells to be attracted to the wound site due to the release of the Von Willebrand factor from the damaged endothelium. Platelets, in turn, release cytokines such as platelet-derived growth factor, which will attract other inflammatory cells to the wound site.

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      43.1
      Seconds
  • Question 27 - An ambulance transports a 37-year-old woman who is having a seizure. She is...

    Correct

    • An ambulance transports a 37-year-old woman who is having a seizure. She is moved to resuscitation and given a benzodiazepine dose, which quickly ends the seizure. You later learn that she has epilepsy and is usually treated with carbamazepine to control her seizures.What is carbamazepine's main mechanism of action?

      Your Answer: Sodium channel blocker

      Explanation:

      Carbamazepine is primarily used to treat epilepsy, and it is effective for both focal and generalised seizures. It is not, however, effective in the treatment of absence or myoclonic seizures. It’s also commonly used to treat neuropathic pain, as well as a second-line treatment for bipolar disorder and as a supplement for acute alcohol withdrawal.Carbamazepine works as a sodium channel blocker that preferentially binds to voltage-gated sodium channels in their inactive state. This prevents an action potential from firing repeatedly and continuously.

    • This question is part of the following fields:

      • CNS Pharmacology
      • Pharmacology
      73.2
      Seconds
  • Question 28 - A 32-year-old man is dehydrated as he presents with severe vomiting and diarrhoea....

    Correct

    • A 32-year-old man is dehydrated as he presents with severe vomiting and diarrhoea. He urgently requires resuscitation with intravenous fluid administration. He is also administered metoclopramide.Which of the following is the true mechanism of action of metoclopramide?

      Your Answer: Dopamine receptor antagonism

      Explanation:

      Metoclopramide is used to treat nausea and vomiting. It works by blocking the central and peripheral D2 (dopamine 2) receptors in the medullary chemoreceptor trigger zone in the vomiting centre (area postrema). It decreases the sensitivity of the visceral sensory nerves that transmit from the GI system to the vomiting centre. Blockade of inhibitory dopamine receptors in the GI tract may allow stimulatory actions of ACh at muscarinic synapses to predominate.At high doses, metoclopramide also blocks type-2 serotonin receptors though the effect is much weaker.

    • This question is part of the following fields:

      • CNS Pharmacology
      • Pharmacology
      53
      Seconds
  • Question 29 - A man working as a waiter cuts his arm on a glass while...

    Incorrect

    • A man working as a waiter cuts his arm on a glass while he was working. The palmaris longus muscle was damaged as a consequence of his injury.Which of the following statements regarding the palmaris longus muscle is considered correct?

      Your Answer: It arises from the lateral epicondyle of the humerus

      Correct Answer: It receives its blood supply from the ulnar artery

      Explanation:

      The palmaris longus is a small, fusiform-shaped muscle located on the anterior forearm of the human upper extremity. The palmaris longus muscle is commonly present but may be absent in a small percentage of the population, ranging from 2.5% to 26% of individuals, depending on the studied population.The palmaris longus belongs to the anterior forearm flexor group in the human upper extremity. The muscle attaches proximally to the medial humeral epicondyle and distally to the palmar aponeurosis and flexor retinaculum. The blood supply to the palmaris longus muscle is via the ulnar artery, a branch of the brachial artery in the human upper extremity.The palmaris longus muscle receives its innervation via branches of the median nerve containing nerve roots C5-T1. Median nerve injury at or above the elbow joint (including brachial plexus and nerve root injury) can lead to deficits in the palmaris longus and other forearm flexor muscles, leading to weakened elbow flexion, wrist flexion, radial deviation, finger flexion, thumb opposition, flexion, and abduction, in addition to the loss of sensory function in the distribution of the median nerve.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      126.3
      Seconds
  • Question 30 - You note that the prostate of a 60-year-old patient is enlarged during the...

    Incorrect

    • You note that the prostate of a 60-year-old patient is enlarged during the examination. You suspect BPH. Anatomically, the prostate has four main lobes. Which of the lobes is affected by benign prostatic hypertrophy?

      Your Answer: Lateral lobe

      Correct Answer: Median lobe

      Explanation:

      Benign prostatic hyperplasia (BPH), also known as benign prostatic hypertrophy, is characterized by an enlarged prostate gland. The prostate is divided into four major lobes. The median lobe is the most commonly affected by benign prostatic enlargement, resulting in urethral obstruction and urine symptoms.

    • This question is part of the following fields:

      • Abdomen
      • Anatomy
      12.5
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

Cardiovascular Pharmacology (1/1) 100%
Pharmacology (5/7) 71%
Pathology (4/6) 67%
Wound Healing (1/1) 100%
Anatomy (3/8) 38%
Upper Limb (0/3) 0%
Lower Limb (1/2) 50%
General Pathology (1/3) 33%
Gastrointestinal Physiology (1/1) 100%
Physiology (4/5) 80%
Abdomen And Pelvis (1/1) 100%
Evidence Based Medicine (0/2) 0%
CNS Pharmacology (3/3) 100%
Microbiology (1/2) 50%
Principles (0/1) 0%
Cardiovascular (1/1) 100%
Haematology (1/1) 100%
Cranial Nerve Lesions (1/1) 100%
Endocrine Physiology (1/2) 50%
Basic Cellular (2/2) 100%
Principles Of Microbiology (1/1) 100%
Immune Responses (1/1) 100%
Gastrointestinal Pharmacology (0/1) 0%
Respiratory Pharmacology (0/1) 0%
Abdomen (0/1) 0%
Passmed