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Question 1
Incorrect
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A recognised side-effect of prefrontal leukotomy is:
Your Answer: Motor aphasia
Correct Answer: Confusion
Explanation:Used previously as a treatment for psychiatric disorders, prefrontal leucotomy severs the connection between the prefrontal cortical association area and the thalamus. This leads to functional isolation of the prefrontal and orbitofrontal association cortex. Thus, along with the desired reduction in anger and frustration, undesirable side effects included changes in mood and affect, as well as confusion.
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This question is part of the following fields:
- Basic Sciences
- Physiology
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Question 2
Incorrect
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A 30 year old carpenter falls off the roof of a house and lands on his right arm. X-ray and clinical examination show that he has fractured the proximal ulna and associated radial dislocation. Which of the following names would be used to describe this injury?
Your Answer: Galeazzi
Correct Answer: Monteggia's
Explanation:The Monteggia fracture refers to a dislocation of the proximal radio-ulnar joint (PRUJ) in association with a forearm fracture, most commonly a fracture of the ulna. Depending on the type of fracture and severity, they may experience elbow swelling, deformity, crepitus, and paraesthesia or numbness. Some patients may not have severe pain at rest, but elbow flexion and forearm rotation are limited and painful.
The dislocated radial head may be palpable in the anterior, posterior, or anterolateral position. In Bado type I and IV lesions, the radial head can be palpated in the antecubital fossa. The radial head can be palpated posteriorly in type II lesions and laterally in type III lesions.Colles’ fractures have the following 3 features:
– Transverse fracture of the radius
– 1 inch proximal to the radio-carpal joint
– Dorsal displacement and angulationSmith’s fracture (reverse Colles’ fracture)
– Volar angulation of distal radius fragment (Garden spade deformity)
– Caused by falling backwards onto the palm of an outstretched hand or falling with wrists flexedBennett’s fracture
– Intra-articular fracture of the first carpometacarpal joint
– Impact on flexed metacarpal, caused by fist fights
– X-ray: triangular fragment at ulnar base of metacarpalGaleazzi fracture
– Radial shaft fracture with associated dislocation of the distal radioulnar jointPott’s fracture
– Bimalleolar ankle fracture
– Forced foot eversionBarton’s fracture
– Distal radius fracture (Colles’/Smith’s) with associated radiocarpal dislocation
– Fall onto extended and pronated wrist
– Involvement of the joint is a defining feature -
This question is part of the following fields:
- Generic Surgical Topics
- Orthopaedics
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Question 3
Incorrect
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A 7 year old boy is taken to the doctor by his mother after she observed a swelling in his right hemiscrotum. On examination, it transilluminates. What is the next best step in his management?
Your Answer: Division of the patent processus vaginalis via a scrotal approach
Correct Answer: Division of the patent processus vaginalis via an inguinal approach
Explanation:The inguinal approach, with ligation of the processus vaginalis high within the internal inguinal ring, is the procedure of choice for paediatric hydroceles (typically, communicating). If a testicular tumour is identified on testicular ultrasonography, an inguinal approach with high control/ligation of the cord structures is mandated.
Approximately 10% of patients with testicular teratomas may present with a cystic mass that may transilluminate during the physical examination. Similarly, adults with testicular tumours may present with new-onset scrotal swelling. If this diagnosis is considered, measuring serum alpha-fetoprotein and human chorionic gonadotropin (hCG) levels is indicated to exclude malignant teratomas or other germ cell tumours.
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This question is part of the following fields:
- Generic Surgical Topics
- Paediatric Surgery
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Question 4
Incorrect
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Where does the ejaculatory duct open into?
Your Answer: Membranous urethra
Correct Answer: Prostatic urethra
Explanation:There are two ejaculatory ducts, one on either side of the midline. Each ejaculatory duct is formed by the union of the duct from the seminal vesicles with the ductus deferens. They start at the base of the prostate and run forward and downward between the middle and lateral lobes and along the side of the prostatic utricle to end in the prostatic urethra.
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This question is part of the following fields:
- Anatomy
- Basic Sciences
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Question 5
Incorrect
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When a patient that is less than 21 years of age develops a bone tumour. What is the most common benign bone tumour that would be considered in individuals below 21 years?
Your Answer: Chondromyxoid fibroma
Correct Answer: Osteochondroma
Explanation:Osteochondroma is a benign new bone growth that protrudes from the outer contour of bones and is capped by growing cartilage. Nearly 80% of these lesions are noted before the age of 21 years.
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This question is part of the following fields:
- Basic Sciences
- Pathology
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Question 6
Incorrect
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Perforin are present in the granules of which cell?
Your Answer: Mast cell
Correct Answer: Natural killer cell
Explanation:Perforins are characteristically found In the granules of CD8+ T cells and natural killer cells. They are cytolytic proteins that insert into the target plasma membrane forming a hole and resulting in lysis. They along with granzyme B induce apoptosis in the target cell.
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This question is part of the following fields:
- Basic Sciences
- Pathology
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Question 7
Incorrect
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A 64 year old man who has undergone a total hip replacement is given an infusion of packed red cells. Which of the following adverse effects is most likely to occur as a result of this treatment?
Your Answer: ABO mismatching
Correct Answer: Pyrexia
Explanation:Acute transfusion reactions present as adverse signs or symptoms during or within 24 hours of a blood transfusion. The most frequent reactions are fever, chills, pruritus, or urticaria, which typically resolve promptly without specific treatment or complications.
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This question is part of the following fields:
- Post-operative Management And Critical Care
- Principles Of Surgery-in-General
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Question 8
Incorrect
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A 55 year old man undergoes a live donor related renal transplant. He has noticed that over the past few years following the transplant, his renal function has progressively deteriorated. What is the most likely underlying explanation?
Your Answer: Type II hypersensitivity reaction
Correct Answer: Type IV hypersensitivity reaction
Explanation:Transplantation is a process by which cells, tissues, or organs (a graft) from the donor are transplanted into a host (or recipient). The immune system’s ability to recognize and respond to foreign antigens bring challenges to transplantation.
Type IV hypersensitivity is characterized by cell-mediated response rather than antibodies as in other types of hypersensitivity reactions. Specifically, the T lymphocytes are involved in the development of the sensitivity, hence called cell-mediated hypersensitivity.
After exposure to antigens, through a series of biochemical events, the T-cells will be activated. By releasing some chemicals, the T-cells activate other white blood cells to mount an immune response.
Rejection of transplant occurs months to years later. In chronic rejection, there is intimal fibrosis with vascular thickening, leading to ischemic changes. Mononuclear infiltrates with prominent plasma cells are present. -
This question is part of the following fields:
- Generic Surgical Topics
- Organ Transplantation
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Question 9
Correct
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A cerebellar tremor can be differentiated from a Parkinsonian tremor in that:
Your Answer: It only occurs during voluntary movements
Explanation:Cerebellar disease leads to intention tremors, which is absent at rest and appears at the onset of voluntary movements. In comparison, Parkinson’s tremor is present at rest. Frequency of tremor is a less reliable means to differentiate between the two as the oscillation amplitude of the tremor is not constant throughout a voluntary action.
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This question is part of the following fields:
- Basic Sciences
- Physiology
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Question 10
Incorrect
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For calculation of cardiac output by Fick's principle, which of the following vessels is the best source of venous blood to determine the arterial-to-venous oxygen tension difference?
Your Answer: Femoral vein
Correct Answer: Pulmonary artery
Explanation:Fick’s principle states that the total uptake (or release) of a substance by peripheral tissues is equal to the product of the blood flow to the peripheral tissues and the arterial– venous concentration difference (gradient) of the substance. It is used to measure the cardiac output, and the formula is Cardiac output = oxygen consumption divided by arteriovenous oxygen difference. Assuming there are no shunts across the pulmonary system, the pulmonary blood flow equals the systemic blood flow. The arterial and venous blood oxygen content is measured by sampling from the pulmonary artery (low oxygen content) and pulmonary vein (high oxygen content). Peripheral arterial blood is used as a surrogate for the pulmonary vein.
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This question is part of the following fields:
- Basic Sciences
- Physiology
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Question 11
Incorrect
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Regarding the extensor retinaculum of the wrist, which of these is CORRECT?
Your Answer: The median nerve runs deep to it
Correct Answer: It prevents the tendons of the posterior compartment of the forearm from ‘bowstringing’ when the hand is extended at the wrist
Explanation:This extensor retinaculum, as the name indicates, holds the tendons of the extensors against the dorsal surface of the distal radius and ulna. Therefore, the correct answer is that it prevents bowstringing of the extensor tendons with wrist extension. It forms compartments between it and its bony attachment, and these compartments guide and hold the tendons.
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This question is part of the following fields:
- Anatomy
- Basic Sciences
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Question 12
Incorrect
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A 33 year old man is diagnosed with CA caecum. Thorough history taking reveals that his mother developed uterine cancer at 39 years of age and his maternal uncle died at 38 due to colonic cancer. Which of the following operative options would be the most suitable for this patient?
Your Answer: Extended right hemicolectomy
Correct Answer: Panproctocolectomy
Explanation:Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is a type of inherited cancer syndrome associated with a genetic predisposition to different cancer types. People who have Lynch syndrome have a significantly increased risk of developing colorectal cancer. There is also an increased risk of developing other types of cancers, such as endometrial (uterine), stomach, breast, ovarian, small bowel (intestinal), pancreatic, prostate, urinary tract, liver, kidney, and bile duct cancers. Alterations in several genes involved in DNA mismatch repair that have been linked to Lynch syndrome. They include the genes of MLH1, MSH2, MSH6, PMS2, and EPCAM. A mutation (alteration) in any of these genes gives a person an increased lifetime risk of developing colorectal cancer and other related cancers.
Women also have an increased risk of developing endometrial and ovarian cancers. The safest operative strategy is a pancolectomy and end ileostomy.
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This question is part of the following fields:
- Colorectal Surgery
- Generic Surgical Topics
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Question 13
Incorrect
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A diabetic 58-year-old man, after the injection of radiographic contrast, has a decreased urine output and decreased level of consciousness. Which of the following conditions has he most likely developed
Your Answer: Acute interstitial nephritis
Correct Answer: Acute tubular necrosis
Explanation:Acute tubular necrosis (ATN) involves damage to the tubule cells of the kidneys and is the most common cause of acute kidney injury. ATN in the majority of the cases is caused by ischaemia of the kidneys due to lack of perfusion and oxygenation but it may also occur due to poison or harmful substance. Contrast used for radiology may cause ATN in patients with several risk factors e.g. diabetic nephropathy. Symptoms may include oliguria, nausea, fluid retention, fatigue and decreased consciousness.
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This question is part of the following fields:
- Basic Sciences
- Pathology
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Question 14
Incorrect
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A 40-year-old man presents to the acute surgical unit with acute pancreatitis. Over the next few days, he becomes dyspnoeic and his saturations are 89% on air and CVP is 16 mmHg. CXR shows bilateral pulmonary infiltrates.What is the most likely diagnosis?
Your Answer: Pneumococcal pneumonia
Correct Answer: Acute respiratory distress syndrome
Explanation:Acute pancreatitis is known to precipitate acute respiratory distress syndrome (ARDS) which is characterised by bilateral pulmonary infiltrates and severe hypoxaemia in the absence of evidence for cardiogenic pulmonary oedema. Pulmonary oedema is excluded by the CVP reading of <18 mmHg in this scenario. ARDS is subdivided into two stages. Early stage consists of an exudative phase of injury with associated oedema. The later stage is one of repair and consists of fibroproliferative changes. Subsequent scarring may result in poor lung function. ARDS can also lead to multiple organ failure. Various causes of ARDS include:
1. Sepsis
2. Direct lung injury
3. Trauma
4. Acute pancreatitis
5. Long bone fracture or multiple fractures (through fat embolism)
6. Head injury (sympathetic nervous stimulation which leads to acute pulmonary hypertension)Management options are:
1. Treat the underlying cause
2. Antibiotics (if signs of sepsis)
3. Negative fluid balance, i.e. diuretics
4. Recruitment manoeuvres such as prone ventilation and use of positive end-expiratory pressure (PEEP)
5. Mechanical ventilation strategy using low tidal volumes, as conventional tidal volumes may cause lung injury (only treatment found to improve survival rates) -
This question is part of the following fields:
- Post-operative Management And Critical Care
- Principles Of Surgery-in-General
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Question 15
Incorrect
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A 44-year old man, who was euthyroid underwent thyroidectomy following neoplastic cells found on fine-needle aspiration. Frozen section of multiple thyroid masses showed malignant neoplasm of polygonal cells in nests. The neoplasm also showed presence of amyloid which was positive with Congo-red staining. Immunoperoxidase staining for calcitonin was also positive. Chest X-ray revealed no abnormality. However, his blood pressure was found to be raised, and his serum ionised calcium was high. What is the likely diagnosis?
Your Answer: Parathyroid carcinoma
Correct Answer: Multiple endocrine neoplasia type IIA
Explanation:MEN (Multiple Endocrine Neoplasia) syndromes are a group of three separate familial disease which consists of adenomatous hyperplasia and neoplasia in several endocrine glands. All three conditions are inherited as an autosomal dominant trait, with a single gene producing multiple effects. MEN IIA is characterized by medullary carcinoma of the thyroid, pheochromocytoma and hyperparathyroidism. It should be suspected in patients with bilateral pheochromocytoma, a familial history of MEN, or at least two characteristic endocrine manifestations. Genetic testing is used to confirm the diagnosis. Early diagnosis is crucial to aid in complete excision of the localized tumour. Pheochromocytomas can be detected by plasma free metanephrines and fractionated urinary catecholamines, particularly adrenaline (epinephrine). Imaging studies such as computed tomography or magnetic resonance imaging might also prove useful. Hyperparathyroidism is diagnosed by the standard finding of hypercalcaemia, hypophosphatemia and an increased parathyroid hormone level. Once MEN IIA syndrome is identified in any patient, it is recommended that his or her first-degree relatives and any other symptomatic also undergo genetic testing. Relatives should be subjected to annual screening for hyperparathyroidism and pheochromocytoma beginning in early childhood and continue indefinitely. Serum calcium levels help in screening for hyperparathyroidism. Similarly, screening for pheochromocytoma is by history, measurement of the blood pressure and laboratory testing.
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This question is part of the following fields:
- Basic Sciences
- Pathology
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Question 16
Incorrect
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What is the percentage of bone calcium that is freely exchangeable with the extracellular fluid that is available for buffering changes in the calcium ion balance?
Your Answer: 15%
Correct Answer: 1%
Explanation:Around 1% of calcium in the body is available for buffering changes in calcium ion balance. These are mainly derived from the bone that are freely exchangeable with extracellular fluid.
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This question is part of the following fields:
- Basic Sciences
- Pathology
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Question 17
Incorrect
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Routine evaluation of a 38 year old gentleman showed a slightly lower arterial oxygen [pa(O2)] than the alveolar oxygen [pA(O2)]. This difference is:
Your Answer: Is due to significant diffusion gradients
Correct Answer: Is normal and due to shunted blood
Explanation:Blood that bypasses the ventilated parts of lung and enters the arterial circulation directly is known as shunted blood. It happens in normal people due to mixing of arterial blood with bronchial and some myocardial venous blood (which drains into the left heart). Diffusion limitation and reaction velocity with haemoglobin are immeasurably small. CO2 unloading will not affect the difference between alveolar and arterial p(O2). A large VSD will result in much lower arterial O2 as compared to alveolar O2.
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This question is part of the following fields:
- Basic Sciences
- Physiology
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Question 18
Correct
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Where would you insert the needle when drawing blood from a patient's median cubital vein?
Your Answer: Anterior aspect of the elbow
Explanation:The correct answer is to insert it into the anterior aspect of the elbow. If you look at the venous drainage of the upper limb, you will find that there are two main veins, the basilic and the cephalic vein; the connecting branch between these two veins is the median cubital vein. and this vein passes via the cubital fossa which is on the anterior aspect of the forearm.
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This question is part of the following fields:
- Anatomy
- Basic Sciences
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Question 19
Incorrect
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A 41 year old woman presents with discomfort in her left breast. On examination, she has a discrete, soft, fluctuant area in the upper outer quadrant of her left breast. A halo sign is observed on the mammogram. What is the most likely explanation for this process?
Your Answer: Atypical ductal hyperplasia
Correct Answer: Breast cyst
Explanation:A breast cyst is a fluid-filled sac within the breast. They are often described as round or oval lumps with distinct edges. In texture, a breast cyst usually feels like a soft grape or a water-filled balloon, but can also feel firm.
Breast cysts can be painful and may be worrisome but are generally benign. They are most common in pre-menopausal women in their 30s or 40s. They usually disappear after menopause, but may persist or reappear when using hormone therapy. They are also common in adolescents. Breast cysts can be part of fibrocystic disease. The pain and swelling is usually worse in the second half of the menstrual cycle or during pregnancy.
The halo sign, described as a complete or partial radiolucent ring surrounding the periphery of a breast mass, has long been considered a mammographic sign indicating a benign process. The phenomenon is most frequently seen with cysts and fibroadenomas.
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This question is part of the following fields:
- Breast And Endocrine Surgery
- Generic Surgical Topics
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Question 20
Incorrect
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A 64 year old man has been in ICU with ARDS for a week following acute pancreatitis. He is being mechanically ventilated. Which of the following is the best option for maintenance of the patency of his airway?
Your Answer: Endotracheal tube
Correct Answer: Tracheostomy
Explanation:Tracheostomy is an operative procedure that creates a surgical airway in the cervical trachea. It is most often performed in patients who have had difficulty weaning off a ventilator, followed by those who have suffered trauma or a catastrophic neurologic insult. High-flow oxygen via tracheostomy may reduce the inspiratory effort and enhance tidal volume by delivering high-flow oxygen and facilitate weaning from prolonged mechanical ventilation in patients with restrictive pulmonary dysfunction.
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This question is part of the following fields:
- Post-operative Management And Critical Care
- Principles Of Surgery-in-General
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Question 21
Incorrect
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An experiment was conducted in which the skeletal muscle protein (not smooth muscle) involved in contraction was selectively inhibited. Which protein was inhibited?
Your Answer: Actin
Correct Answer: Troponin
Explanation:The mechanism of contraction of smooth muscles is different from that of skeletal muscles in which the contractile protein is troponin whilst in smooth muscle contraction is a protein called calmodulin. Calmodulin reacts with calcium ions and stimulates the formation of myosin crossbridges.
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This question is part of the following fields:
- Basic Sciences
- Physiology
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Question 22
Incorrect
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Which of the following arteries, that runs on the superior aspect of the first part of the duodenum, forms the lower boundary of the epiploic foramen (also known as the foramen of Winslow)?
Your Answer: Superior pancreaticoduodenal
Correct Answer: Hepatic
Explanation:The epiploic foramen is an important anatomical opening that allows for the communication between the greater peritoneal sac and the lesser peritoneal sac. Its boundaries are formed; superiorly by the caudate lobe of the liver, anteriorly by the hepatoduodenal ligament (containing the components of the portal triad), inferiorly by the first part of the duodenum and posteriorly by the peritoneum covering the inferior vena cava. The superior aspect of the first part of the duodenum, which forms the inferior boundary of the foramen of Winslow, forms the course of the hepatic artery before it ascends to the porta hepatis where it divides into its right and left branches.
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This question is part of the following fields:
- Anatomy
- Basic Sciences
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Question 23
Incorrect
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A 24-year-old woman presents with an infected sebaceous cyst. On examination, it is swollen, erythematous, and discharging pus. What should be the most appropriate treatment?
Your Answer: Incision and drainage with conservation of the cyst wall and packing of the defect
Correct Answer: Incision and drainage with excision of the cyst wall and packing of the defect
Explanation:The correct treatment for an infected sebaceous cyst is incision and drainage with removal of the cyst wall. Conservation of the cyst wall invariably leads to recurrence. Furthermore, the infected wound must not be primarily closed. The administration of antibiotics without drainage of sepsis is futile.
A sebaceous cyst is a rounded swollen area of the skin formed by an abnormal sac of retained excretion (sebum) from the sebaceous follicles. It can occur anywhere but is most commonly formed on scalp, ears, back, face, and upper arm (not on palms of the hands and soles of the feet). The correct treatment for an infected sebaceous cyst is incision and drainage with removal of the cyst wall. Excision of the cyst wall needs to be complete to prevent recurrence.
Cock’s peculiar tumour is a suppurating and ulcerated sebaceous cyst, which may resemble a squamous cell carcinoma.
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This question is part of the following fields:
- Generic Surgical Topics
- Skin Lesions
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Question 24
Incorrect
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Thalamic syndrome will most likely result in:
Your Answer: Thirst
Correct Answer: Hyperaesthesia
Explanation:Signs and symptoms of thalamic syndrome include contralateral hemi anaesthesia, burning or aching sensation in one half of a body (hyperaesthesia), often accompanied by mood swings.
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This question is part of the following fields:
- Basic Sciences
- Physiology
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Question 25
Incorrect
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What forms the pelvic diaphragm?
Your Answer: Levator ani and piriformis muscles
Correct Answer: Levator ani and coccygeus muscles
Explanation:The pelvic diaphragm is formed by the levator ani and the coccygeus muscles. The levator ani forms the greater part of the pelvic floor supporting the viscera in the pelvic cavity.
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This question is part of the following fields:
- Anatomy
- Basic Sciences
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Question 26
Incorrect
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The muscle that stabilizes the stapes is innervated by which of the following nerves?
Your Answer: Cranial nerve VIII
Correct Answer: Facial nerve
Explanation:The stapedius is the smallest skeletal muscle in the human body. At just over one millimetre in length, its purpose is to stabilize the smallest bone in the body, the stapes and is innervated by a branch of the facial nerve.
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This question is part of the following fields:
- Anatomy
- Basic Sciences
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Question 27
Correct
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A lesion involving the lateral geniculate nucleus of the thalamus is likely to affect:
Your Answer: Vision
Explanation:The lateral geniculate nucleus (LGN) of the thalamus is the primary processor of visual information in the central nervous system. The LGN receives information directly from the retina and sends projections directly to the primary visual cortex. The LGN likely helps the visual system focus its attention on the most important information.
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This question is part of the following fields:
- Basic Sciences
- Physiology
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Question 28
Incorrect
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A 9 year old boy is admitted with right iliac fossa pain and an appendicectomy is to be performed.Which of the following incision is the best for this procedure?
Your Answer: Kockers
Correct Answer: Lanz
Explanation:Answer: Lanz
The Lanz and Gridiron incisions are two incisions that can be used to access the appendix, predominantly for appendectomy.
Both incisions are made at McBurney’s point (two-thirds from the umbilicus to the anterior superior iliac spine). They involve passing through all of the abdominal muscles, transversalis fascia, and then the peritoneum, before entering the abdominal cavity.
The Lanz incision is a transverse incision, whilst the Gridiron incision is oblique (superolateral to inferomedial). Due to its continuation with Langer’s lines, the Lanz incision produces much more aesthetically pleasing results with reduced scarring.
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This question is part of the following fields:
- Generic Surgical Topics
- The Abdomen
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Question 29
Incorrect
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A young girl who presented with a clinical picture of type I hypersensitivity reaction with eosinophilia is most likely to have?
Your Answer: Dust inhalation
Correct Answer: Liver flukes
Explanation:Usually a parasitic infection will be associated with a type I hypersensitivity reaction.
Amyloid deposition will not cause an immune reaction.
Organic dust will lead to a type III hypersensitivity reaction.
Cell mediated as well as humoral immune mechanism play a part in syphilis, but they are do not specifically cause a type I reaction.
Malaria is cause by plasmodium and is not cause of a hypersensitivity reaction.
Atopic dermatitis will not be accompanied by eosinophilia. -
This question is part of the following fields:
- Basic Sciences
- Pathology
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Question 30
Incorrect
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A 30-year-old male presents to the clinic with a recurrent thyroid cyst. It has been drained on three different occasions. Each time the cyst is aspirated and cytology is reassuring. What is the most appropriate course of action?
Your Answer: Total thyroidectomy
Correct Answer: Resection of the ipsilateral thyroid lobe
Explanation:Aspiration is the treatment of choice in thyroid cysts, but the recurrence rates are high (60%–90% of patients), particularly with repeated aspirations and large-volume cysts.
Percutaneous ethanol injection (PEI) has been studied in several large randomized controlled studies, with reported success in 82–85% of the cases after an average of 2 sessions, with a volume reduction of more than 85% from baseline size.
PEI may also be considered for hyperfunctioning nodules, particularly if a large fluid component is present. It has a success rate ranging from 64% to 95%, with a mean volume reduction of 66%, but recurrences are more common and the number of sessions required to achieve good response is higher (about 4 sessions per patient). PEI is a safe procedure, with the most common reported adverse effects being local pain, dysphonia, flushing, dizziness, and, rarely, recurrent laryngeal nerve damage.
Surgery, Lobectomy is also a reasonable therapy for cystic lesions, as an alternative to the previously mentioned procedures. -
This question is part of the following fields:
- Breast And Endocrine Surgery
- Generic Surgical Topics
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