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  • Question 1 - What is a true statement about the HCR-20? ...

    Correct

    • What is a true statement about the HCR-20?

      Your Answer: It can be completed individually of by a team

      Explanation:

      One of the primary criticisms of the HCR-20 is its failure to account for protective factors. While formal training is not required to use the tool, it is recommended. Additionally, the HCR-20 only assesses the risk of violence towards people and does not consider violence towards animals of property. The value of the HCR-20 lies in the process of completing it, rather than the final score, which is considered meaningless and cannot be used to determine dangerousness. The HCR-20 can be completed by an individual of a team.

      The HCR-20 is a comprehensive tool used to assess the risk of violence in adults. It takes into account various factors from the past, present, and future to provide a holistic view of the individual’s risk. The tool consists of 20 items, which are divided into three domains: historical, clinical, and risk management.

      The historical domain includes factors such as previous violence, young age at first violent incident, relationship instability, employment problems, substance use problems, major mental illness, psychopathy, early maladjustment, personality disorder, and prior supervision failure. These factors are important to consider as they provide insight into the individual’s past behavior and potential risk for future violence.

      The clinical domain includes factors such as lack of insight, negative attitudes, active symptoms of major mental illness, impulsivity, and unresponsiveness to treatment. These factors are important to consider as they provide insight into the individual’s current mental state and potential risk for future violence.

      The risk management domain includes factors such as plans lack feasibility, exposure to destabilizers, lack of personal support, noncompliance with remediation attempts, and stress. These factors are important to consider as they provide insight into the individual’s ability to manage their risk and potential for future violence.

      Overall, the HCR-20 is a valuable tool for assessing the risk of violence in adults. It provides a comprehensive view of the individual’s risk and can be used to inform treatment and risk management strategies.

    • This question is part of the following fields:

      • Forensic Psychiatry
      14
      Seconds
  • Question 2 - Which statement accurately describes atomoxetine? ...

    Correct

    • Which statement accurately describes atomoxetine?

      Your Answer: It can increase the risk of suicidal ideation

      Explanation:

      Patients should be cautioned about the potential for short-term suicidal thoughts when using atomoxetine, particularly if previous treatments with methylphenidate and lisdexamfetamine have been unsuccessful.

      ADHD (Diagnosis and Management in Children)

      ADHD is a behavioural syndrome characterised by symptoms of inattention, hyperactivity, and impulsivity. The DSM-5 and ICD-11 provide diagnostic criteria for the condition, with both recognising three subtypes: predominantly inattentive, predominantly hyperactive-impulsive, and combined.

      Treatment for children under 5 involves offering an ADHD-focused group parent-training programme as a first-line option. Medication should only be considered after obtaining advice from a specialist ADHD service. For children and young people aged 5-18, advice and support should be given, along with an ADHD-focused group parent-training programme. Medication should only be offered if ADHD symptoms persist after environmental modifications have been implemented and reviewed. Cognitive behavioural therapy may also be considered for those who have benefited from medication but still experience significant impairment.

      NICE advises against elimination diets, dietary fatty acid supplementation, and the use of the ‘few foods diet’. Methylphenidate of lisdexamfetamine is the first-line medication option, with dexamphetamine considered for those who respond to lisdexamfetamine but cannot tolerate the longer effect profile. Atomoxetine of guanfacine may be offered for those who cannot tolerate methylphenidate of lisdexamfetamine. Clonidine and atypical antipsychotics should only be used with advice from a tertiary ADHD service.

      Drug holidays may be considered for children and young people who have not met the expected height for their age due to medication. However, NICE advises that withdrawal from treatment is associated with a risk of symptom exacerbation.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      42.7
      Seconds
  • Question 3 - Arrange the following research studies in the correct order based on their level...

    Incorrect

    • Arrange the following research studies in the correct order based on their level of evidence.

      Your Answer: Systematic review of RCTs, RCTs, cohort, cross-sectional, case-control, case-series

      Correct Answer: Systematic review of RCTs, RCTs, cohort, case-control, cross-sectional, case-series

      Explanation:

      While many individuals can readily remember that the systematic review is at the highest level and case-series at the lowest, it can be difficult to correctly sequence the intermediate levels.

      Levels and Grades of Evidence in Evidence-Based Medicine

      To evaluate the quality of evidence on a subject of question, levels of grades are used. The traditional hierarchy approach places systematic reviews of randomized control trials at the top and case-series/report at the bottom. However, this approach is overly simplistic as certain research questions cannot be answered using RCTs. To address this, the Oxford Centre for Evidence-Based Medicine introduced their 2011 Levels of Evidence system, which separates the type of study questions and gives a hierarchy for each.

      The grading approach to be aware of is the GRADE system, which classifies the quality of evidence as high, moderate, low, of very low. The process begins by formulating a study question and identifying specific outcomes. Outcomes are then graded as critical of important. The evidence is then gathered and criteria are used to grade the evidence, with the type of evidence being a significant factor. Evidence can be promoted of downgraded based on certain criteria, such as limitations to study quality, inconsistency, uncertainty about directness, imprecise of sparse data, and reporting bias. The GRADE system allows for the promotion of observational studies to high-quality evidence under the right circumstances.

    • This question is part of the following fields:

      • Research Methods, Statistics, Critical Review And Evidence-Based Practice
      12.2
      Seconds
  • Question 4 - What is the NNT for the following study data in a population of...

    Correct

    • What is the NNT for the following study data in a population of patients over the age of 65?
      Medication Group vs Control Group
      Events: 30 vs 80
      Non-events: 120 vs 120
      Total subjects: 150 vs 200.

      Your Answer: 5

      Explanation:

      To calculate the event rates for the medication and control groups, we divide the number of events by the total number of subjects in each group. For the medication group, the event rate is 0.2 (30/150), and for the control group, it is 0.4 (80/200).

      We can also calculate the absolute risk reduction (ARR) by subtracting the event rate in the medication group from the event rate in the control group: ARR = CER – EER = 0.4 – 0.2 = 0.2.

      Finally, we can use the ARR to calculate the number needed to treat (NNT), which represents the number of patients who need to be treated with the medication to prevent one additional event compared to the control group. NNT = 1/ARR = 1/0.2 = 5.

    • This question is part of the following fields:

      • Research Methods, Statistics, Critical Review And Evidence-Based Practice
      58.5
      Seconds
  • Question 5 - What is a true statement about correlation? ...

    Correct

    • What is a true statement about correlation?

      Your Answer: Complete absence of correlation is expressed by a value of 0

      Explanation:

      Stats: Correlation and Regression

      Correlation and regression are related but not interchangeable terms. Correlation is used to test for association between variables, while regression is used to predict values of dependent variables from independent variables. Correlation can be linear, non-linear, of non-existent, and can be strong, moderate, of weak. The strength of a linear relationship is measured by the correlation coefficient, which can be positive of negative and ranges from very weak to very strong. However, the interpretation of a correlation coefficient depends on the context and purposes. Correlation can suggest association but cannot prove of disprove causation. Linear regression, on the other hand, can be used to predict how much one variable changes when a second variable is changed. Scatter graphs are used in correlation and regression analyses to visually determine if variables are associated and to detect outliers. When constructing a scatter graph, the dependent variable is typically placed on the vertical axis and the independent variable on the horizontal axis.

    • This question is part of the following fields:

      • Research Methods, Statistics, Critical Review And Evidence-Based Practice
      25.9
      Seconds
  • Question 6 - One of the following treatments would not be recommended for a young girl...

    Correct

    • One of the following treatments would not be recommended for a young girl with attention deficit hyperactivity disorder who also has liver disease.

      Your Answer: Pemoline

      Explanation:

      Pemoline, which is utilized to treat ADHD as a CNS stimulant, has been linked to severe liver failure that can be fatal.

      ADHD (Diagnosis and Management in Children)

      ADHD is a behavioural syndrome characterised by symptoms of inattention, hyperactivity, and impulsivity. The DSM-5 and ICD-11 provide diagnostic criteria for the condition, with both recognising three subtypes: predominantly inattentive, predominantly hyperactive-impulsive, and combined.

      Treatment for children under 5 involves offering an ADHD-focused group parent-training programme as a first-line option. Medication should only be considered after obtaining advice from a specialist ADHD service. For children and young people aged 5-18, advice and support should be given, along with an ADHD-focused group parent-training programme. Medication should only be offered if ADHD symptoms persist after environmental modifications have been implemented and reviewed. Cognitive behavioural therapy may also be considered for those who have benefited from medication but still experience significant impairment.

      NICE advises against elimination diets, dietary fatty acid supplementation, and the use of the ‘few foods diet’. Methylphenidate of lisdexamfetamine is the first-line medication option, with dexamphetamine considered for those who respond to lisdexamfetamine but cannot tolerate the longer effect profile. Atomoxetine of guanfacine may be offered for those who cannot tolerate methylphenidate of lisdexamfetamine. Clonidine and atypical antipsychotics should only be used with advice from a tertiary ADHD service.

      Drug holidays may be considered for children and young people who have not met the expected height for their age due to medication. However, NICE advises that withdrawal from treatment is associated with a risk of symptom exacerbation.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      24.3
      Seconds
  • Question 7 - What is a risk management factor included in the HCR-20? ...

    Correct

    • What is a risk management factor included in the HCR-20?

      Your Answer: Exposure to destabilizers

      Explanation:

      The HCR-20 is a comprehensive tool used to assess the risk of violence in adults. It takes into account various factors from the past, present, and future to provide a holistic view of the individual’s risk. The tool consists of 20 items, which are divided into three domains: historical, clinical, and risk management.

      The historical domain includes factors such as previous violence, young age at first violent incident, relationship instability, employment problems, substance use problems, major mental illness, psychopathy, early maladjustment, personality disorder, and prior supervision failure. These factors are important to consider as they provide insight into the individual’s past behavior and potential risk for future violence.

      The clinical domain includes factors such as lack of insight, negative attitudes, active symptoms of major mental illness, impulsivity, and unresponsiveness to treatment. These factors are important to consider as they provide insight into the individual’s current mental state and potential risk for future violence.

      The risk management domain includes factors such as plans lack feasibility, exposure to destabilizers, lack of personal support, noncompliance with remediation attempts, and stress. These factors are important to consider as they provide insight into the individual’s ability to manage their risk and potential for future violence.

      Overall, the HCR-20 is a valuable tool for assessing the risk of violence in adults. It provides a comprehensive view of the individual’s risk and can be used to inform treatment and risk management strategies.

    • This question is part of the following fields:

      • Forensic Psychiatry
      14.4
      Seconds
  • Question 8 - What is the method used for ultra rapid opiate detoxification? ...

    Correct

    • What is the method used for ultra rapid opiate detoxification?

      Your Answer: Naloxone

      Explanation:

      The use of high doses of opioid antagonists (naloxone and naltrexone) in ultra-rapid detox (over 24 hours) and rapid detox (over 1-5 days) is common. However, ultra-rapid detox is typically performed under general anesthesia, while rapid detox is usually done with some sedation. Despite this, NICE does not support the use of ultra-rapid detox. NICE recommends that rapid detox be offered only to individuals who specifically request it, provided that the service can safely provide it.

      Opioid Maintenance Therapy and Detoxification

      Withdrawal symptoms can occur after as little as 5 days of regular opioid use. Short-acting opioids like heroin have acute withdrawal symptoms that peak in 32-72 hours and last for 3-5 days. Longer-acting opioids like methadone have acute symptoms that peak at day 4-6 and last for 10 days. Buprenorphine withdrawal lasts up to 10 days and includes symptoms like myalgia, anxiety, and increased drug craving.

      Opioids affect the brain through opioid receptors, with the µ receptor being the main target for opioids. Dopaminergic cells in the ventral tegmental area produce dopamine, which is released into the nucleus accumbens upon stimulation of µ receptors, producing euphoria and reward. With repeat opioid exposure, µ receptors become less responsive, causing dysphoria and drug craving.

      Methadone and buprenorphine are maintenance-oriented treatments for opioid dependence. Methadone is a full agonist targeting µ receptors, while buprenorphine is a partial agonist targeting µ receptors and a partial k agonist of functional antagonist. Naloxone and naltrexone are antagonists targeting all opioid receptors.

      Methadone is preferred over buprenorphine for detoxification, and ultra-rapid detoxification should not be offered. Lofexidine may be considered for mild of uncertain dependence. Clonidine and dihydrocodeine should not be used routinely in opioid detoxification. The duration of detoxification should be up to 4 weeks in an inpatient setting and up to 12 weeks in a community setting.

      Pregnant women dependent on opioids should use opioid maintenance treatment rather than attempt detoxification. Methadone is preferred over buprenorphine, and transfer to buprenorphine during pregnancy is not advised. Detoxification should only be considered if appropriate for the women’s wishes, circumstances, and ability to cope. Methadone or buprenorphine treatment is not a contraindication to breastfeeding.

    • This question is part of the following fields:

      • Substance Misuse/Addictions
      26.1
      Seconds
  • Question 9 - Which of the following is not considered a known factor that increases the...

    Incorrect

    • Which of the following is not considered a known factor that increases the risk of developing Charles Bonnet Syndrome?

      Your Answer: Social isolation

      Correct Answer: Polypharmacy

      Explanation:

      Charles Bonnet Syndrome: A Condition of Complex Visual Hallucinations

      Charles Bonnet Syndrome (CBS) is a condition characterized by persistent of recurrent complex visual hallucinations that occur in clear consciousness. This condition is observed in individuals who have suffered damage to the visual pathway, which can be caused by damage to any part of the pathway from the eye to the cortex. The hallucinations are thought to result from a release phenomenon secondary to the deafferentation of the cerebral cortex. CBS is equally distributed between sexes and does not show any familial predisposition. The most common ophthalmological conditions associated with this syndrome are age-related macular degeneration, followed by glaucoma and cataract.

      Risk factors for CBS include advanced age, peripheral visual impairment, social isolation, sensory deprivation, and early cognitive impairment. Well-formed complex visual hallucinations are thought to occur in 10-30 percent of individuals with severe visual impairment. Only around a third of individuals find the hallucinations themselves an unpleasant or disturbing experience. The most effective treatment is reversal of the visual impairment. Antipsychotic drugs are commonly prescribed but are largely ineffective. CBS is a long-lasting condition, with 88% of individuals experiencing it for two years of more, and only 25% resolving at nine years.

    • This question is part of the following fields:

      • Old Age Psychiatry
      23.3
      Seconds
  • Question 10 - What is the first line treatment recommended by NICE for school age children...

    Incorrect

    • What is the first line treatment recommended by NICE for school age children and young people with attention deficit hyperactivity disorder with moderate impairment?

      Your Answer: Methylphenidate

      Correct Answer: Parental training programmes

      Explanation:

      ADHD (Diagnosis and Management in Children)

      ADHD is a behavioural syndrome characterised by symptoms of inattention, hyperactivity, and impulsivity. The DSM-5 and ICD-11 provide diagnostic criteria for the condition, with both recognising three subtypes: predominantly inattentive, predominantly hyperactive-impulsive, and combined.

      Treatment for children under 5 involves offering an ADHD-focused group parent-training programme as a first-line option. Medication should only be considered after obtaining advice from a specialist ADHD service. For children and young people aged 5-18, advice and support should be given, along with an ADHD-focused group parent-training programme. Medication should only be offered if ADHD symptoms persist after environmental modifications have been implemented and reviewed. Cognitive behavioural therapy may also be considered for those who have benefited from medication but still experience significant impairment.

      NICE advises against elimination diets, dietary fatty acid supplementation, and the use of the ‘few foods diet’. Methylphenidate of lisdexamfetamine is the first-line medication option, with dexamphetamine considered for those who respond to lisdexamfetamine but cannot tolerate the longer effect profile. Atomoxetine of guanfacine may be offered for those who cannot tolerate methylphenidate of lisdexamfetamine. Clonidine and atypical antipsychotics should only be used with advice from a tertiary ADHD service.

      Drug holidays may be considered for children and young people who have not met the expected height for their age due to medication. However, NICE advises that withdrawal from treatment is associated with a risk of symptom exacerbation.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      19.4
      Seconds
  • Question 11 - NICE has made a recommendation for the treatment of antisocial personality disorder, but...

    Incorrect

    • NICE has made a recommendation for the treatment of antisocial personality disorder, but the specific recommendation is not provided in the given information.

      Your Answer: Hypnotherapy

      Correct Answer: Group based cognitive interventions

      Explanation:

      NICE suggests that individuals with antisocial personality disorder, including those who struggle with substance misuse, who are receiving care in community and mental health services, should be offered group-based cognitive and behavioural interventions. These interventions aim to tackle issues such as impulsivity, interpersonal challenges, and antisocial behaviour.

      Personality Disorder (Antisocial / Dissocial)

      Antisocial personality disorder is characterized by impulsive, irresponsible, and often criminal behavior. The criteria for this disorder differ somewhat between the ICD-11 and DSM-5. The ICD-11 abolished all categories of personality disorder except for a general description of personality disorder. This diagnosis can be further specified as “mild,” “moderate,” of “severe.” Patient behavior can be described using one of more of five personality trait domains; negative affectivity, dissociality, anankastic, detachment, and disinhibition. Clinicians may also specify a borderline pattern qualifier.

      The core feature of dissociality is a disregard for the rights and feelings of others, encompassing both self-centeredness and lack of empathy. Common manifestations of Dissociality include self-centeredness and lack of empathy. The DSM-5 defines antisocial personality disorder as a pervasive pattern of disregard for and violation of the rights of others, occurring since age 15, as indicated by three (of more) of the following: failure to conform to social norms with respect to lawful behaviors, deceitfulness, impulsivity of failure to plan ahead, irritability and aggressiveness, reckless disregard for safety of self of others, consistent irresponsibility, and lack of remorse.

      Prevalence estimates are between 1%-6% in men and between 0.2-0.8% in women. Antisocial behaviors typically have their onset before age 8 years. Nearly 80% of people with ASPD developed their first symptom by age 11 years. Boys develop symptoms earlier than girls, who may not develop symptoms until puberty. An estimated 25% of girls and 40% of boys with Conduct Disorder will later meet criteria for ASPD.

      The 2009 NICE Guidelines essentially make two recommendations on treatment: consider offering group-based cognitive and behavioral interventions and pharmacological interventions should not be routinely used for the treatment of antisocial personality disorder of associated behaviors of aggression, anger, and impulsivity. A Cochrane review found that there is not enough good quality evidence to recommend of reject any psychological treatment for people with a diagnosis of AsPD.

      The term psychopathy has varied meanings. Some use the term synonymously with APD and consider it to represent the severe end of the spectrum of APD. Others maintain a clear distinction between psychopathy and APD. Psychopathy has been said to be a richer (broader) concept than APD. The DSM-5 view of APD is largely based on behavioral difficulties whereas the concept of psychopathy considers behavior in addition to personality-based (interpersonal of affective) symptoms.

    • This question is part of the following fields:

      • Forensic Psychiatry
      9.3
      Seconds
  • Question 12 - What intervention has been supported by placebo-controlled randomized controlled trials as effective in...

    Correct

    • What intervention has been supported by placebo-controlled randomized controlled trials as effective in managing aggression among individuals with dementia?

      Your Answer: Risperidone

      Explanation:

      Management of Non-Cognitive Symptoms in Dementia

      Non-cognitive symptoms of dementia can include agitation, aggression, distress, psychosis, depression, anxiety, sleep problems, wandering, hoarding, sexual disinhibition, apathy, and shouting. Non-pharmacological measures, such as music therapy, should be considered before prescribing medication. Pain may cause agitation, so a trial of analgesics is recommended. Antipsychotics, such as risperidone, olanzapine, and aripiprazole, may be used for severe distress of serious risk to others, but their use is controversial due to issues of tolerability and an association with increased mortality. Cognitive enhancers, such as AChE-Is and memantine, may have a modest benefit on BPSD, but their effects may take 3-6 months to take effect. Benzodiazepines should be avoided except in emergencies, and antidepressants, such as citalopram and trazodone, may have mixed evidence for BPSD. Mood stabilizers, such as valproate and carbamazepine, have limited evidence to support their use. Sedating antihistamines, such as promethazine, may cause cognitive impairment and should only be used short-term. Melatonin has limited evidence to support its use but is safe to use and may be justified in some cases where benefits are seen. For Lewy Body dementia, clozapine is favored over risperidone, and quetiapine may be a reasonable choice if clozapine is not appropriate. Overall, medication should only be used when non-pharmacological measures are ineffective, and the need is balanced with the increased risk of adverse effects.

    • This question is part of the following fields:

      • Old Age Psychiatry
      14.1
      Seconds
  • Question 13 - What is the highest possible punishment for possessing synthetic cannabinoids in the United...

    Incorrect

    • What is the highest possible punishment for possessing synthetic cannabinoids in the United Kingdom?

      Your Answer: Possession is not illegal

      Correct Answer: 5 years

      Explanation:

      At first, the Psychoactive Substances Act only criminalized the production and supply of certain substances, while possession was still legal. However, in January 2017, synthetic cannabinoids such as Spice were reclassified as Class B drugs under the Misuse of Drugs Act, making possession of these substances illegal.

      Drug Misuse (Law and Scheduling)

      The Misuse of Drugs Act (1971) regulates the possession and supply of drugs, classifying them into three categories: A, B, and C. The maximum penalty for possession varies depending on the class of drug, with Class A drugs carrying a maximum sentence of 7 years.

      The Misuse of Drugs Regulations 2001 further categorizes controlled drugs into five schedules. Schedule 1 drugs are considered to have no therapeutic value and cannot be lawfully possessed of prescribed, while Schedule 2 drugs are available for medical use but require a controlled drug prescription. Schedule 3, 4, and 5 drugs have varying levels of restrictions and requirements.

      It is important to note that a single drug can have multiple scheduling statuses, depending on factors such as strength and route of administration. For example, morphine and codeine can be either Schedule 2 of Schedule 5.

      Overall, the Misuse of Drugs Act and Regulations aim to regulate and control the use of drugs in the UK, with the goal of reducing drug misuse and related harm.

    • This question is part of the following fields:

      • Substance Misuse/Addictions
      4.2
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  • Question 14 - One of Bion's fundamental group assumptions is: ...

    Incorrect

    • One of Bion's fundamental group assumptions is:

      Your Answer: Cohesiveness

      Correct Answer: Pairing

      Explanation:

      Bion, a psychoanalyst, was fascinated by group dynamics and believed that groups had a collective unconscious that functioned similarly to that of an individual. He argued that this unconsciousness protected the group from the pain of reality. Bion identified two types of groups: the ‘working group’ that functioned well and achieved its goals, and the ‘basic assumption group’ that acted out primitive fantasies and prevented progress. Bion then described different types of basic assumption groups, including ‘dependency,’ where the group turns to a leader to alleviate anxiety, ‘fight-flight,’ where the group perceives an enemy and either attacks of avoids them, and ‘pairing,’ where the group believes that the solution lies in the pairing of two members. These dynamics can be observed in various settings, such as when strangers come together for the first time of when doctors in different specialties criticize one another.

    • This question is part of the following fields:

      • Psychotherapy
      5.5
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  • Question 15 - A man who has recently turned 60 and is still taking medication for...

    Correct

    • A man who has recently turned 60 and is still taking medication for hypertension develops mania. He fails to respond to olanzapine. Considering the fact that he is taking medication for hypertension, which of the following is the most appropriate next step?

      Your Answer: Quetiapine

      Explanation:

      Paroxetine Use During Pregnancy: Is it Safe?

      Prescribing medication during pregnancy and breastfeeding is challenging due to the potential risks to the fetus of baby. No psychotropic medication has a UK marketing authorization specifically for pregnant of breastfeeding women. Women are encouraged to breastfeed unless they are taking carbamazepine, clozapine, of lithium. The risk of spontaneous major malformation is 2-3%, with drugs accounting for approximately 5% of all abnormalities. Valproate and carbamazepine are associated with an increased risk of neural tube defects, and lithium is associated with cardiac malformations. Benzodiazepines are associated with oral clefts and floppy baby syndrome. Antidepressants have been linked to preterm delivery and congenital malformation, but most findings have been inconsistent. TCAs have been used widely without apparent detriment to the fetus, but their use in the third trimester is known to produce neonatal withdrawal effects. Sertraline appears to result in the least placental exposure among SSRIs. MAOIs should be avoided in pregnancy due to a suspected increased risk of congenital malformations and hypertensive crisis. If a pregnant woman is stable on an antipsychotic and likely to relapse without medication, she should continue the antipsychotic. Depot antipsychotics should not be offered to pregnant of breastfeeding women unless they have a history of non-adherence with oral medication. The Maudsley Guidelines suggest specific drugs for use during pregnancy and breastfeeding. NICE CG192 recommends high-intensity psychological interventions for moderate to severe depression and anxiety disorders. Antipsychotics are recommended for pregnant women with mania of psychosis who are not taking psychotropic medication. Promethazine is recommended for insomnia.

    • This question is part of the following fields:

      • General Adult Psychiatry
      15.4
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  • Question 16 - What are some factors that increase the risk of developing schizophrenia? ...

    Correct

    • What are some factors that increase the risk of developing schizophrenia?

      Your Answer: Being a migrant

      Explanation:

      The AESOP study provides the latest evidence that being a migrant significantly increases the likelihood of developing schizophrenia, as it is a well-established risk factor.

      Schizophrenia: Understanding the Risk Factors

      Social class is a significant risk factor for schizophrenia, with people of lower socioeconomic status being more likely to develop the condition. Two hypotheses attempt to explain this relationship, one suggesting that environmental exposures common in lower social class conditions are responsible, while the other suggests that people with schizophrenia tend to drift towards the lower class due to their inability to compete for good jobs.

      While early studies suggested that schizophrenia was more common in black populations than in white, the current consensus is that there are no differences in rates of schizophrenia by race. However, there is evidence that rates are higher in migrant populations and ethnic minorities.

      Gender and age do not appear to be consistent risk factors for schizophrenia, with conflicting evidence on whether males of females are more likely to develop the condition. Marital status may also play a role, with females with schizophrenia being more likely to marry than males.

      Family history is a strong risk factor for schizophrenia, with the risk increasing significantly for close relatives of people with the condition. Season of birth and urban versus rural place of birth have also been shown to impact the risk of developing schizophrenia.

      Obstetric complications, particularly prenatal nutritional deprivation, brain injury, and influenza, have been identified as significant risk factors for schizophrenia. Understanding these risk factors can help identify individuals who may be at higher risk for developing the condition and inform preventative measures.

    • This question is part of the following fields:

      • General Adult Psychiatry
      8.6
      Seconds
  • Question 17 - A 7-year-old girl has been referred to your clinic due to concerns raised...

    Correct

    • A 7-year-old girl has been referred to your clinic due to concerns raised by her parents and teachers regarding her inability to focus, impulsivity, and restlessness, which have negatively impacted her academic performance. Which genetic polymorphism is most pertinent to the development of this condition?

      Your Answer: Human dopamine transporter gene (DAT1)

      Explanation:

      The genetic polymorphisms that are associated with the development of hyperkinetic disorder (ADHD) include dopamine transporter (DAT1) and dopamine receptor related (DRD4). On the other hand, DBP, DISC1, and NRG are polymorphisms that are relevant to schizophrenia, while APP is associated with Alzheimer’s disease. Additionally, the DISC1 gene is believed to increase the likelihood of developing bipolar disorder and major depressive disorder.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      12.3
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  • Question 18 - A manic adolescent who has already had 3 manic episodes in the past...

    Incorrect

    • A manic adolescent who has already had 3 manic episodes in the past 10 months is admitted to hospital for treatment. He is currently taking both lithium and valproate at maximum dose. Which of the following would be appropriate as an augmentation agent?

      Your Answer: Tranylcypromine

      Correct Answer: Quetiapine

      Explanation:

      If a patient is experiencing mania, it is important to avoid administering antidepressants such as dosulepin, moclobemide, and tranylcypromine as they may exacerbate the condition. Instead, the Maudsley recommends the use of quetiapine and other appropriate medications.

      Bipolar Disorder: Diagnosis and Management

      Bipolar disorder is a lifelong condition characterized by episodes of mania or hypomania and episodes of depressed mood. The peak age of onset is 15-19 years, and the lifetime prevalence of bipolar I disorders is estimated to be around 2.1%. The diagnosis of bipolar disorder is based on the presence of manic or hypomanic episodes, which are characterized by elevated of expansive mood, rapid speech, and increased activity of energy. Psychotic symptoms, such as delusions and hallucinations, may also be present.

      Bipolar depression differs from unipolar depression in several ways, including more rapid onset, more frequent episodes, and shorter duration. Rapid cycling is a qualifier that can be applied to bipolar I of bipolar II disorder and is defined as the presence of at least four mood episodes in the previous 12 months that meet the criteria for a manic, hypomanic, of major depressive episode.

      The management of bipolar disorder involves acute and long-term interventions. Acute management of mania or hypomania may involve stopping antidepressants and offering antipsychotics of mood stabilizers. Long-term management may involve psychological interventions and pharmacological treatments such as lithium, valproate, of olanzapine.

      It is important to note that valproate should not be offered to women of girls of childbearing potential for long-term bipolar disorder unless other options are ineffective of not tolerated and a pregnancy prevention program is in place. Aripiprazole is recommended as an option for treating moderate to severe manic episodes in adolescents with bipolar I disorder.

      Overall, the diagnosis and management of bipolar disorder require a comprehensive approach that takes into account the individual’s symptoms, history, and preferences.

    • This question is part of the following fields:

      • General Adult Psychiatry
      33.6
      Seconds
  • Question 19 - In the management of acute mania in adult patients, NICE recommends which of...

    Correct

    • In the management of acute mania in adult patients, NICE recommends which of the following?

      Your Answer: Risperidone

      Explanation:

      Bipolar Disorder: Diagnosis and Management

      Bipolar disorder is a lifelong condition characterized by episodes of mania or hypomania and episodes of depressed mood. The peak age of onset is 15-19 years, and the lifetime prevalence of bipolar I disorders is estimated to be around 2.1%. The diagnosis of bipolar disorder is based on the presence of manic or hypomanic episodes, which are characterized by elevated of expansive mood, rapid speech, and increased activity of energy. Psychotic symptoms, such as delusions and hallucinations, may also be present.

      Bipolar depression differs from unipolar depression in several ways, including more rapid onset, more frequent episodes, and shorter duration. Rapid cycling is a qualifier that can be applied to bipolar I of bipolar II disorder and is defined as the presence of at least four mood episodes in the previous 12 months that meet the criteria for a manic, hypomanic, of major depressive episode.

      The management of bipolar disorder involves acute and long-term interventions. Acute management of mania or hypomania may involve stopping antidepressants and offering antipsychotics of mood stabilizers. Long-term management may involve psychological interventions and pharmacological treatments such as lithium, valproate, of olanzapine.

      It is important to note that valproate should not be offered to women of girls of childbearing potential for long-term bipolar disorder unless other options are ineffective of not tolerated and a pregnancy prevention program is in place. Aripiprazole is recommended as an option for treating moderate to severe manic episodes in adolescents with bipolar I disorder.

      Overall, the diagnosis and management of bipolar disorder require a comprehensive approach that takes into account the individual’s symptoms, history, and preferences.

    • This question is part of the following fields:

      • General Adult Psychiatry
      9.1
      Seconds
  • Question 20 - Which of the following is guided by the principle of reality? ...

    Correct

    • Which of the following is guided by the principle of reality?

      Your Answer: Ego

      Explanation:

      Freud’s Structural Theory: Understanding the Three Areas of the Mind

      According to Freud’s structural model, the human mind is divided into three distinct areas: the Id, the Ego, and the Superego. The Id is the part of the mind that contains instinctive drives and operates on the ‘pleasure principle’. It functions without a sense of time and is governed by ‘primary process thinking’. The Ego, on the other hand, attempts to modify the drives from the Id with external reality. It operates on the ‘reality principle’ and has conscious, preconscious, and unconscious aspects. It is also home to the defense mechanisms. Finally, the Superego acts as a critical agency, constantly observing a person’s behavior. Freud believed that it developed from the internalized values of a child’s main caregivers. The Superego contains the ‘ego ideal’, which represents ideal attitudes and behavior. It is often referred to as the conscience. Understanding these three areas of the mind is crucial to understanding Freud’s structural theory.

    • This question is part of the following fields:

      • Psychotherapy
      4.7
      Seconds
  • Question 21 - A middle-aged patient remembers taking a medication for schizophrenia some time ago but...

    Correct

    • A middle-aged patient remembers taking a medication for schizophrenia some time ago but cannot recall its name. They were cautioned that it could cause sun sensitivity and advised to use ample sun protection while on it. What medication do you think they might have been given?

      Your Answer: Chlorpromazine

      Explanation:

      Chlorpromazine: Photosensitivity Reactions and Patient Precautions

      Chlorpromazine, the first drug used for psychosis, is a common topic in exams. However, it is important to note that photosensitivity reactions are a known side effect of its use. Patients taking chlorpromazine should be informed of this and advised to take necessary precautions. Proper education and awareness can help prevent potential harm from photosensitivity reactions.

    • This question is part of the following fields:

      • General Adult Psychiatry
      11.5
      Seconds
  • Question 22 - What is the most frequently observed neuro-ophthalmic symptom of Wernicke's? ...

    Correct

    • What is the most frequently observed neuro-ophthalmic symptom of Wernicke's?

      Your Answer: Horizontal gaze-evoked nystagmus

      Explanation:

      Wernicke’s disease affects both the efferent and afferent visual systems, resulting in various neuro-ophthalmic manifestations. The ocular motor abnormalities range from mild to severe, with horizontal gaze-evoked nystagmus being the most common ophthalmic sign. Bilateral abducens palsy and conjugate gaze palsies, mostly horizontal, are also frequently observed. Although complete ophthalmoplegia is often mentioned as part of the classic triad, it is a rare occurrence in Wernicke’s disease. Unilateral internuclear ophthalmoplegia is rarely reported, and bilateral cases are exceptionally rare, with only one case found.

      Wernicke’s Encephalopathy: Symptoms, Causes, and Treatment

      Wernicke’s encephalopathy is a serious condition that is characterized by confusion, ophthalmoplegia, and ataxia. However, the complete triad is only present in 10% of cases, which often leads to underdiagnosis. The condition results from prolonged thiamine deficiency, which is commonly seen in people with alcohol dependency, but can also occur in other conditions such as anorexia nervosa, malignancy, and AIDS.

      The onset of Wernicke’s encephalopathy is usually abrupt, but it may develop over several days to weeks. The lesions occur in a symmetrical distribution in structures surrounding the third ventricle, aqueduct, and fourth ventricle. The mammillary bodies are involved in up to 80% of cases, and atrophy of these structures is specific for Wernicke’s encephalopathy.

      Treatment involves intravenous thiamine, as oral forms of B1 are poorly absorbed. IV glucose should be avoided when thiamine deficiency is suspected as it can precipitate of exacerbate Wernicke’s. With treatment, ophthalmoplegia and confusion usually resolve within days, but the ataxia, neuropathy, and nystagmus may be prolonged of permanent.

      Untreated cases of Wernicke’s encephalopathy can lead to Korsakoff’s syndrome, which is characterized by memory impairment associated with confabulation. The mortality rate associated with Wernicke’s encephalopathy is 10-20%, making early diagnosis and treatment crucial.

    • This question is part of the following fields:

      • Substance Misuse/Addictions
      4.9
      Seconds
  • Question 23 - What is a characteristic of skewed data? ...

    Correct

    • What is a characteristic of skewed data?

      Your Answer: For positively skewed data the mean is greater than the mode

      Explanation:

      Skewed Data: Understanding the Relationship between Mean, Median, and Mode

      When analyzing a data set, it is important to consider the shape of the distribution. In a normally distributed data set, the curve is symmetrical and bell-shaped, with the median, mode, and mean all equal. However, in skewed data sets, the distribution is asymmetrical, with the bulk of the data concentrated on one side of the figure.

      In a negatively skewed distribution, the left tail is longer, and the bulk of the data is concentrated to the right of the figure. In contrast, a positively skewed distribution has a longer right tail, with the bulk of the data concentrated to the left of the figure. In both cases, the median is positioned between the mode and the mean, as it represents the halfway point of the distribution.

      However, the mean is affected by extreme values of outliers, causing it to move away from the median in the direction of the tail. In positively skewed data, the mean is greater than the median, which is greater than the mode. In negatively skewed data, the mode is greater than the median, which is greater than the mean.

      Understanding the relationship between mean, median, and mode in skewed data sets is crucial for accurate data analysis and interpretation. By recognizing the shape of the distribution, researchers can make informed decisions about which measures of central tendency to use and how to interpret their results.

    • This question is part of the following fields:

      • Research Methods, Statistics, Critical Review And Evidence-Based Practice
      15.6
      Seconds
  • Question 24 - Which of the options below is not considered a legal requirement for testamentary...

    Correct

    • Which of the options below is not considered a legal requirement for testamentary capacity?

      Your Answer: Understands that the will can be revised

      Explanation:

      Testamentary Capacity

      Testamentary capacity is a crucial aspect of common law that pertains to a person’s legal and mental ability to create a will. To meet the requirements for testamentary capacity, there are four key factors that a testator must be aware of at the time of making the will. These include knowing the extent and value of their property, identifying the natural beneficiaries, understanding the disposition they are making, and having a plan for how the property will be distributed.

    • This question is part of the following fields:

      • Old Age Psychiatry
      7.6
      Seconds
  • Question 25 - What is the recommended course of treatment for a man who experiences depression...

    Correct

    • What is the recommended course of treatment for a man who experiences depression after a heart attack?

      Your Answer: Sertraline

      Explanation:

      SSRI for Post-MI Depression

      Post-myocardial infarction (MI), approximately 20% of people develop depression, which can worsen prognosis if left untreated. Selective serotonin reuptake inhibitors (SSRIs) are the preferred antidepressant group for post-MI depression. However, they can increase the risk of bleeding, especially in those using anticoagulation. Mirtazapine is an alternative option, but it is also associated with bleeding. The SADHART study found sertraline to be a safe treatment for depression post-MI. It is important to consider the bleeding risk when choosing an antidepressant for post-MI depression.

      References:
      – Davies, P. (2004). Treatment of anxiety and depressive disorders in patients with cardiovascular disease. BMJ, 328, 939-943.
      – Glassman, A. H. (2002). Sertraline treatment of major depression in patients with acute MI of unstable angina. JAMA, 288, 701-709.
      – Goodman, M. (2008). Incident and recurrent major depressive disorder and coronary artery disease severity in acute coronary syndrome patients. Journal of Psychiatric Research, 42, 670-675.
      – Na, K. S. (2018). Can we recommend mirtazapine and bupropion for patients at risk for bleeding? A systematic review and meta-analysis. Journal of Affective Disorders, 225, 221-226.

    • This question is part of the following fields:

      • Old Age Psychiatry
      9.7
      Seconds
  • Question 26 - What is the method used to establish accountability for criminal actions? ...

    Incorrect

    • What is the method used to establish accountability for criminal actions?

      Your Answer: Edwards and Gross criteria

      Correct Answer: McNaughten rules

      Explanation:

      The issue of consent in individuals under the age of 16 is evaluated through the Gillick test, while cases of medical negligence are assessed using the Bolam test.

      Criminal Responsibility and Age Limits

      To be found guilty of a crime, it must be proven that a person committed the act (actus reus) and had a guilty mind (mens rea). In England and Wales, children under the age of 10 cannot be held criminally responsible for their actions and cannot be arrested or charged with a crime. Instead, they may face other punishments such as a Local Child Curfew of a Child Safety Order. Children between the ages of 10 and 17 can be arrested and taken to court, but are treated differently from adults and may be dealt with by youth courts, given different sentences, and sent to special secure centers for young people. Young people aged 18 are treated as adults by the law.

      Not Guilty by Reason of Insanity and Other Defenses

      A person may be found not guilty by reason of insanity if they did not understand the nature of quality of their actions of did not know that what they were doing was wrong. Automatism is a defense used when the act is believed to have occurred unconsciously, either from an external cause (sane automatism) of an internal cause (insane automatism). Diminished responsibility is a defense used only in the defense of murder and allows for a reduction of the normal life sentence to manslaughter.

    • This question is part of the following fields:

      • Forensic Psychiatry
      15.3
      Seconds
  • Question 27 - What measures should be taken to address erratic compliance in individuals with bipolar...

    Correct

    • What measures should be taken to address erratic compliance in individuals with bipolar disorder?

      Your Answer: Lithium

      Explanation:

      Patients who are likely to have poor compliance should avoid intermittent treatment with lithium as it can exacerbate the natural progression of bipolar disorder, according to the Maudsley 13th Edition.

      Bipolar Disorder: Diagnosis and Management

      Bipolar disorder is a lifelong condition characterized by episodes of mania or hypomania and episodes of depressed mood. The peak age of onset is 15-19 years, and the lifetime prevalence of bipolar I disorders is estimated to be around 2.1%. The diagnosis of bipolar disorder is based on the presence of manic or hypomanic episodes, which are characterized by elevated of expansive mood, rapid speech, and increased activity of energy. Psychotic symptoms, such as delusions and hallucinations, may also be present.

      Bipolar depression differs from unipolar depression in several ways, including more rapid onset, more frequent episodes, and shorter duration. Rapid cycling is a qualifier that can be applied to bipolar I of bipolar II disorder and is defined as the presence of at least four mood episodes in the previous 12 months that meet the criteria for a manic, hypomanic, of major depressive episode.

      The management of bipolar disorder involves acute and long-term interventions. Acute management of mania or hypomania may involve stopping antidepressants and offering antipsychotics of mood stabilizers. Long-term management may involve psychological interventions and pharmacological treatments such as lithium, valproate, of olanzapine.

      It is important to note that valproate should not be offered to women of girls of childbearing potential for long-term bipolar disorder unless other options are ineffective of not tolerated and a pregnancy prevention program is in place. Aripiprazole is recommended as an option for treating moderate to severe manic episodes in adolescents with bipolar I disorder.

      Overall, the diagnosis and management of bipolar disorder require a comprehensive approach that takes into account the individual’s symptoms, history, and preferences.

    • This question is part of the following fields:

      • General Adult Psychiatry
      5.3
      Seconds
  • Question 28 - A middle-aged patient is referred to secondary care due to issues with depression....

    Correct

    • A middle-aged patient is referred to secondary care due to issues with depression. You see the man several times and his depression responds well to treatment with an SSRI.

      During consultations, you are struck by the man’s excessive formality and seriousness. On further enquiry you identify that he has significant difficulties at work. He explains that he is overworked and feels he can't ask colleagues for help as they are unable to do the job properly. He feels that despite all his hard work he is still underperforming in his job. He reports also feeling that he is an inadequate father and reports that his children complain about his refusal to spend money and enjoy himself.

      Which of the following ICD-11 conditions do you most suspect?:

      Your Answer: Personality disorder with anankastic

      Explanation:

      Personality Disorder (Obsessive Compulsive)

      Obsessive-compulsive personality disorder is characterized by a preoccupation with orderliness, perfectionism, and control, which can hinder flexibility and efficiency. This pattern typically emerges in early adulthood and can be present in various contexts. The estimated prevalence ranges from 2.1% to 7.9%, with males being diagnosed twice as often as females.

      The DSM-5 diagnosis requires the presence of four of more of the following criteria: preoccupation with details, rules, lists, order, organization, of agenda to the point that the key part of the activity is lost; perfectionism that hampers completing tasks; extreme dedication to work and efficiency to the elimination of spare time activities; meticulous, scrupulous, and rigid about etiquettes of morality, ethics, of values; inability to dispose of worn-out of insignificant things even when they have no sentimental meaning; unwillingness to delegate tasks of work with others except if they surrender to exactly their way of doing things; miserly spending style towards self and others; and rigidity and stubbornness.

      The ICD-11 abolished all categories of personality disorder except for a general description of personality disorder, which can be further specified as “mild,” “moderate,” of “severe.” The anankastic trait domain is characterized by a narrow focus on one’s rigid standard of perfection and of right and wrong, and on controlling one’s own and others’ behavior and controlling situations to ensure conformity to these standards. Common manifestations of anankastic include perfectionism and emotional and behavioral constraint.

      Differential diagnosis includes OCD, hoarding disorder, narcissistic personality disorder, antisocial personality disorder, and schizoid personality disorder. OCD is distinguished by the presence of true obsessions and compulsions, while hoarding disorder should be considered when hoarding is extreme. Narcissistic personality disorder individuals are more likely to believe that they have achieved perfection, while those with obsessive-compulsive personality disorder are usually self-critical. Antisocial personality disorder individuals lack generosity but will indulge themselves, while those with obsessive-compulsive personality disorder adopt a miserly spending style toward both self and others. Schizoid personality disorder is characterized by a fundamental lack of capacity for intimacy, while in obsessive-compulsive personality disorder, this stems from discomfort with emotions and excessive devotion to work.

    • This question is part of the following fields:

      • General Adult Psychiatry
      40.1
      Seconds
  • Question 29 - Among the adverse effects linked to clozapine, which one is least likely to...

    Correct

    • Among the adverse effects linked to clozapine, which one is least likely to increase in severity with higher doses?

      Your Answer: Agranulocytosis

      Explanation:

      There is no association between the risk of agranulocytosis and either the dose of plasma concentration of clozapine, according to Bishara (2014).

      Clozapine is an effective antipsychotic drug used in the management of treatment-resistant schizophrenia (TRS). It was reintroduced in the 1990s with mandatory blood monitoring due to the risk of agranulocyte

    • This question is part of the following fields:

      • General Adult Psychiatry
      14.1
      Seconds
  • Question 30 - Which drug interacts with a G-coupled receptor to exert its effects? ...

    Incorrect

    • Which drug interacts with a G-coupled receptor to exert its effects?

      Your Answer: Ketamine

      Correct Answer: Cannabis

      Explanation:

      Mechanisms of action for illicit drugs can be classified based on their effects on ionotropic receptors of ion channels, G coupled receptors, of monoamine transporters. Cocaine and amphetamine both increase dopamine levels in the synaptic cleft, but through different mechanisms. Cocaine directly blocks the dopamine transporter, while amphetamine binds to the transporter and increases dopamine efflux through various mechanisms, including inhibition of vesicular monoamine transporter 2 and monoamine oxidase, and stimulation of the intracellular receptor TAAR1. These mechanisms result in increased dopamine levels in the synaptic cleft and reuptake inhibition.

    • This question is part of the following fields:

      • General Adult Psychiatry
      5.3
      Seconds
  • Question 31 - What steps should be taken to rule out other possible causes before diagnosing...

    Correct

    • What steps should be taken to rule out other possible causes before diagnosing a child with encopresis?

      Your Answer: Hirschsprung's disease

      Explanation:

      Elimination Disorders

      Elimination disorders refer to conditions that affect a child’s ability to control their bladder of bowel movements. Enuresis, of lack of control over the bladder, typically occurs between the ages of 1-3, while control over the bowel usually occurs before that of the bladder for most toddlers. Toilet training can be influenced by various factors, including intellectual capacity, cultural determinants, and psychological interactions between the child and their parents.

      Enuresis is characterized by involuntary voiding of urine, by day and/of by night, which is abnormal in relation to the individual’s age and is not a result of any physical abnormality. It is not normally diagnosed before age 5 and may be primary (the child never having achieved continence) of secondary. Treatment options include reassurance, enuresis alarms, and medication.

      Encopresis refers to repeated stool evacuation in inappropriate places in children over the age of four. The behavior can be either involuntary of intentional and may be due to unsuccessful toilet training (primary encopresis) of occur after a period of normal bowel control (secondary encopresis). Treatment generally involves bowel clearance, prevention of impaction, and behavioral therapy.

      Before a diagnosis of encopresis is made, organic causes must be excluded. Hirschsprung’s disease is a condition that results from an absence of parasympathetic ganglion cells in the rectum, colon, and sometimes the small intestine. It leads to a colonic obstruction and is diagnosed in at least half of all cases in the first year of life. It is twice as common in boys than in girls.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      6.8
      Seconds
  • Question 32 - Which of the subsequent reasons for demise does not necessitate a medical professional...

    Incorrect

    • Which of the subsequent reasons for demise does not necessitate a medical professional to inform the coroner, regardless of age?

      Your Answer: Death of a patient on section 17 leave from hospital

      Correct Answer: Death of any inpatient on a psychiatric ward

      Explanation:

      Guidance for Registered Medical Practitioners on the Notification of Deaths Regulations 2019

      For informal patients in psychiatric hospital, there is no automatic statutory requirement to inform the senior coroner. However, if another criterion is fulfilled, such as death due to poisoning, violence of trauma, self-harm, neglect, medical procedure, employment-related injury of disease, unnatural death, unknown cause of death, death in custody, of unknown identity of the deceased, then the coroner should be informed. It is important to note that there is no requirement to notify the coroner for those subject to DOLS. This national guidance replaces any local protocols.

    • This question is part of the following fields:

      • Organisation And Delivery Of Psychiatric Services
      37.8
      Seconds
  • Question 33 - What characteristic is associated with Obsessive-compulsive personality disorder? ...

    Correct

    • What characteristic is associated with Obsessive-compulsive personality disorder?

      Your Answer: Unwillingness to pass on tasks to others except if they surrender to exactly their way of doing things

      Explanation:

      Individuals with obsessive compulsive personality disorder tend to be hesitant to delegate tasks to others unless they conform to their specific methods and preferences.

      Personality Disorder (Obsessive Compulsive)

      Obsessive-compulsive personality disorder is characterized by a preoccupation with orderliness, perfectionism, and control, which can hinder flexibility and efficiency. This pattern typically emerges in early adulthood and can be present in various contexts. The estimated prevalence ranges from 2.1% to 7.9%, with males being diagnosed twice as often as females.

      The DSM-5 diagnosis requires the presence of four of more of the following criteria: preoccupation with details, rules, lists, order, organization, of agenda to the point that the key part of the activity is lost; perfectionism that hampers completing tasks; extreme dedication to work and efficiency to the elimination of spare time activities; meticulous, scrupulous, and rigid about etiquettes of morality, ethics, of values; inability to dispose of worn-out of insignificant things even when they have no sentimental meaning; unwillingness to delegate tasks of work with others except if they surrender to exactly their way of doing things; miserly spending style towards self and others; and rigidity and stubbornness.

      The ICD-11 abolished all categories of personality disorder except for a general description of personality disorder, which can be further specified as “mild,” “moderate,” of “severe.” The anankastic trait domain is characterized by a narrow focus on one’s rigid standard of perfection and of right and wrong, and on controlling one’s own and others’ behavior and controlling situations to ensure conformity to these standards. Common manifestations of anankastic include perfectionism and emotional and behavioral constraint.

      Differential diagnosis includes OCD, hoarding disorder, narcissistic personality disorder, antisocial personality disorder, and schizoid personality disorder. OCD is distinguished by the presence of true obsessions and compulsions, while hoarding disorder should be considered when hoarding is extreme. Narcissistic personality disorder individuals are more likely to believe that they have achieved perfection, while those with obsessive-compulsive personality disorder are usually self-critical. Antisocial personality disorder individuals lack generosity but will indulge themselves, while those with obsessive-compulsive personality disorder adopt a miserly spending style toward both self and others. Schizoid personality disorder is characterized by a fundamental lack of capacity for intimacy, while in obsessive-compulsive personality disorder, this stems from discomfort with emotions and excessive devotion to work.

    • This question is part of the following fields:

      • General Adult Psychiatry
      20.2
      Seconds
  • Question 34 - Which of the options below is not a valid means of supporting a...

    Correct

    • Which of the options below is not a valid means of supporting a diagnosis of obsessive compulsive personality disorder?

      Your Answer: Views self as inferior to others

      Explanation:

      It is important to note that while individuals with obsessive personality disorder may experience feelings of inferiority, this is not a defining characteristic of the disorder. In contrast, a diagnosis of avoidant personality disorder may be more appropriate for individuals who consistently view themselves as inferior to others.

      Personality Disorder (Obsessive Compulsive)

      Obsessive-compulsive personality disorder is characterized by a preoccupation with orderliness, perfectionism, and control, which can hinder flexibility and efficiency. This pattern typically emerges in early adulthood and can be present in various contexts. The estimated prevalence ranges from 2.1% to 7.9%, with males being diagnosed twice as often as females.

      The DSM-5 diagnosis requires the presence of four of more of the following criteria: preoccupation with details, rules, lists, order, organization, of agenda to the point that the key part of the activity is lost; perfectionism that hampers completing tasks; extreme dedication to work and efficiency to the elimination of spare time activities; meticulous, scrupulous, and rigid about etiquettes of morality, ethics, of values; inability to dispose of worn-out of insignificant things even when they have no sentimental meaning; unwillingness to delegate tasks of work with others except if they surrender to exactly their way of doing things; miserly spending style towards self and others; and rigidity and stubbornness.

      The ICD-11 abolished all categories of personality disorder except for a general description of personality disorder, which can be further specified as “mild,” “moderate,” of “severe.” The anankastic trait domain is characterized by a narrow focus on one’s rigid standard of perfection and of right and wrong, and on controlling one’s own and others’ behavior and controlling situations to ensure conformity to these standards. Common manifestations of anankastic include perfectionism and emotional and behavioral constraint.

      Differential diagnosis includes OCD, hoarding disorder, narcissistic personality disorder, antisocial personality disorder, and schizoid personality disorder. OCD is distinguished by the presence of true obsessions and compulsions, while hoarding disorder should be considered when hoarding is extreme. Narcissistic personality disorder individuals are more likely to believe that they have achieved perfection, while those with obsessive-compulsive personality disorder are usually self-critical. Antisocial personality disorder individuals lack generosity but will indulge themselves, while those with obsessive-compulsive personality disorder adopt a miserly spending style toward both self and others. Schizoid personality disorder is characterized by a fundamental lack of capacity for intimacy, while in obsessive-compulsive personality disorder, this stems from discomfort with emotions and excessive devotion to work.

    • This question is part of the following fields:

      • General Adult Psychiatry
      19.8
      Seconds
  • Question 35 - What is the recommended approach by NICE for managing distress in patients with...

    Correct

    • What is the recommended approach by NICE for managing distress in patients with delirium?

      Your Answer: Haloperidol

      Explanation:

      Delirium Management

      Pharmacological management of delirium includes the use of haloperidol as a prophylactic measure. NICE guidelines recommend short-term use of haloperidol in cases where delirium is associated with distress of risk to self/others. Quetiapine is also considered a first-choice option in many units. Lorazepam can be used as an alternative if haloperidol is contraindicated, but it is more likely to cause respiratory depression, over-sedation, and paradoxical excitement.

      Non-pharmacological management of delirium includes appropriate lighting and clear signage, talking to the person to reorient them, cognitively stimulating activities, regular visits from family and friends, and promoting good sleep patterns. Additional options such as donepezil, rivastigmine, melatonin, trazodone, and sodium valproate are not recommended. It is important to carefully consider the individual’s needs and medical history when choosing a management plan for delirium.

    • This question is part of the following fields:

      • Old Age Psychiatry
      4.6
      Seconds
  • Question 36 - Which risk factor is commonly associated with schizophrenia based on the findings of...

    Incorrect

    • Which risk factor is commonly associated with schizophrenia based on the findings of the AESOP study?

      Your Answer: Family history

      Correct Answer: Ethnicity and race

      Explanation:

      Schizophrenia: Understanding the Risk Factors

      Social class is a significant risk factor for schizophrenia, with people of lower socioeconomic status being more likely to develop the condition. Two hypotheses attempt to explain this relationship, one suggesting that environmental exposures common in lower social class conditions are responsible, while the other suggests that people with schizophrenia tend to drift towards the lower class due to their inability to compete for good jobs.

      While early studies suggested that schizophrenia was more common in black populations than in white, the current consensus is that there are no differences in rates of schizophrenia by race. However, there is evidence that rates are higher in migrant populations and ethnic minorities.

      Gender and age do not appear to be consistent risk factors for schizophrenia, with conflicting evidence on whether males of females are more likely to develop the condition. Marital status may also play a role, with females with schizophrenia being more likely to marry than males.

      Family history is a strong risk factor for schizophrenia, with the risk increasing significantly for close relatives of people with the condition. Season of birth and urban versus rural place of birth have also been shown to impact the risk of developing schizophrenia.

      Obstetric complications, particularly prenatal nutritional deprivation, brain injury, and influenza, have been identified as significant risk factors for schizophrenia. Understanding these risk factors can help identify individuals who may be at higher risk for developing the condition and inform preventative measures.

    • This question is part of the following fields:

      • General Adult Psychiatry
      12.1
      Seconds
  • Question 37 - What is a true statement about St John's Wort? ...

    Correct

    • What is a true statement about St John's Wort?

      Your Answer: It may cause early development of macular degeneration

      Explanation:

      St John’s Wort, like other antidepressants, can lead to hypomania. While it is generally better tolerated than SSRIs, it is not recommended due to uncertainty about its active ingredient. There are potential risks associated with its use, including early macular degeneration and a risk of bleeding. Common side effects include dry mouth, nausea, constipation, fatigue, dizziness, headache, and restlessness. These considerations are outlined in the Maudsley Guidelines 10th Edition.

      Herbal Remedies for Depression and Anxiety

      Depression can be treated with Hypericum perforatum (St John’s Wort), which has been found to be more effective than placebo and as effective as standard antidepressants. However, its use is not advised due to uncertainty about appropriate doses, variation in preparations, and potential interactions with other drugs. St John’s Wort can cause serotonin syndrome and decrease levels of drugs such as warfarin and ciclosporin. The effectiveness of the combined oral contraceptive pill may also be reduced.

      Anxiety can be reduced with Piper methysticum (kava), but it cannot be recommended for clinical use due to its association with hepatotoxicity.

    • This question is part of the following fields:

      • General Adult Psychiatry
      53
      Seconds
  • Question 38 - Which of the following symptoms would not be indicative of PTSD in a...

    Correct

    • Which of the following symptoms would not be indicative of PTSD in a soldier who has been referred by their GP due to concerns about mental health issues resulting from their experience in the Iraq war?

      Your Answer: He is planning to return to Iraq to seek revenge

      Explanation:

      It is typical for individuals with PTSD to try to steer clear of circumstances that trigger memories of the traumatic event.

      Stress disorders, such as Post Traumatic Stress Disorder (PTSD), are emotional reactions to traumatic events. The diagnosis of PTSD requires exposure to an extremely threatening of horrific event, followed by the development of a characteristic syndrome lasting for at least several weeks, consisting of re-experiencing the traumatic event, deliberate avoidance of reminders likely to produce re-experiencing, and persistent perceptions of heightened current threat. Additional clinical features may include general dysphoria, dissociative symptoms, somatic complaints, suicidal ideation and behaviour, social withdrawal, excessive alcohol of drug use, anxiety symptoms, and obsessions of compulsions. The emotional experience of individuals with PTSD commonly includes anger, shame, sadness, humiliation, of guilt. The onset of PTSD symptoms can occur at any time during the lifespan following exposure to a traumatic event, and the symptoms and course of PTSD can vary significantly over time and individuals. Key differentials include acute stress reaction, adjustment disorder, and complex PTSD. Management of PTSD includes trauma-focused cognitive behavioral therapy (CBT), eye movement desensitization and reprocessing (EMDR), and supported trauma-focused computerized CBT interventions. Drug treatments, including benzodiazepines, are not recommended for the prevention of treatment of PTSD in adults, but venlafaxine of a selective serotonin reuptake inhibitor (SSRI) may be considered for adults with a diagnosis of PTSD if the person has a preference for drug treatment. Antipsychotics such as risperidone may be considered in addition if disabling symptoms and behaviors are present and have not responded to other treatments. Psychological debriefing is not recommended for the prevention of treatment of PTSD. For children and young people, individual trauma-focused CBT interventions of EMDR may be considered, but drug treatments are not recommended.

    • This question is part of the following fields:

      • General Adult Psychiatry
      13.1
      Seconds
  • Question 39 - A young woman with bipolar disorder who takes lithium has become pregnant. Despite...

    Correct

    • A young woman with bipolar disorder who takes lithium has become pregnant. Despite the potential teratogenic effects on the baby, she refuses to stop lithium as it has been the only medication that has effectively managed her symptoms in the past. What course of action would you recommend in this situation?

      Your Answer: Continue on the current dose of lithium and monitor monthly until week 36 and then weekly thereafter

      Explanation:

      It is important to take the patient’s wishes into consideration and simply telling her to stop taking lithium is not appropriate. Providing her with all the necessary information and assisting her in making a decision is the best course of action. According to the NICE Guidelines, it is recommended to continue the current dose of lithium and monitor levels monthly until week 36, and then weekly thereafter. It is common for levels to decrease during pregnancy, so adjustments to the dose may be necessary to maintain therapeutic levels.

      Bipolar Disorder in Women of Childbearing Potential

      Prophylaxis is recommended for women with bipolar disorder, as postpartum relapse rates are high. Women without prophylactic pharmacotherapy during pregnancy have a postpartum relapse rate of 66%, compared to 23% for women with prophylaxis. Antipsychotics are recommended for pregnant women with bipolar disorder, according to NICE Guidelines (CG192) and the Maudsley. Women taking valproate, lithium, carbamazepine, of lamotrigine should discontinue treatment and start an antipsychotic, especially if taking valproate. If a woman with bipolar disorder is taking lithium and becomes pregnant, she should gradually stop lithium over a 4 week period and start an antipsychotic. If this is not possible, lithium levels must be taken regularly, and the dose adjusted accordingly. For acute mania, an antipsychotic should be considered. For mild depressive symptoms, self-help approaches, brief psychological interventions, and antidepressant medication can be considered. For moderate to severe depressive symptoms, psychological treatment (CBT) for moderate depression and combined medication and structured psychological interventions for severe depression should be considered.

      Reference: Wesseloo, R., Kamperman, A. M., Munk-Olsen, T., Pop, V. J., Kushner, S. A., & Bergink, V. (2016). Risk of postpartum relapse in bipolar disorder and postpartum psychosis: a systematic review and meta-analysis. The American Journal of Psychiatry, 173(2), 117-127.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 40 - What symptoms of effects are typical in a patient who has ingested hallucinogenic...

    Incorrect

    • What symptoms of effects are typical in a patient who has ingested hallucinogenic substances?

      Your Answer: Enhanced sociability

      Correct Answer: Tachycardia

      Explanation:

      Illicit drugs, also known as illegal drugs, are substances that are prohibited by law and can have harmful effects on the body and mind. Some of the most commonly used illicit drugs in the UK include opioids, amphetamines, cocaine, MDMA (ecstasy), cannabis, and hallucinogens.

      Opioids, such as heroin, are highly addictive and can cause euphoria, drowsiness, constipation, and respiratory depression. Withdrawal symptoms may include piloerection, insomnia, restlessness, dilated pupils, yawning, sweating, and abdominal cramps.

      Amphetamines and cocaine are stimulants that can increase energy, cause insomnia, hyperactivity, euphoria, and paranoia. Withdrawal symptoms may include hypersomnia, hyperphagia, depression, irritability, agitation, vivid dreams, and increased appetite.

      MDMA, also known as ecstasy, can cause increased energy, sweating, jaw clenching, euphoria, enhanced sociability, and increased response to touch. Withdrawal symptoms may include depression, insomnia, depersonalisation, and derealisation.

      Cannabis, also known as marijuana of weed, can cause relaxation, intensified sensory experience, paranoia, anxiety, and injected conjunctiva. Withdrawal symptoms may include insomnia, reduced appetite, and irritability.

      Hallucinogens, such as LSD, can cause perceptual changes, pupillary dilation, tachycardia, sweating, palpitations, tremors, and incoordination. There is no recognised withdrawal syndrome for hallucinogens.

      Ketamine, also known as Vitamin K, Super K, Special K, of donkey dust, can cause euphoria, dissociation, ataxia, and hallucinations. There is no recognised withdrawal syndrome for ketamine.

    • This question is part of the following fields:

      • Substance Misuse/Addictions
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  • Question 41 - What is a true statement about problem gambling? ...

    Incorrect

    • What is a true statement about problem gambling?

      Your Answer: It is more common in upper than in lower classes

      Correct Answer: It is more common in people with psychiatric problems

      Explanation:

      Problem Gambling: Screening and Interventions

      Problem gambling, also known as pathological gambling, refers to gambling that causes harm to personal, family, of recreational pursuits. The prevalence of problem gambling in adults ranges from 7.3% to 0.7%, while in psychiatric patients, it ranges from 6% to 12%. Problem gambling typically starts in early adolescence in males and runs a chronic, progressive course with periods of abstinence and relapses.

      Screening for problem gambling is done using various tools, including the NODS-CLiP and the South Oaks Gambling Screen (SOGS). Brief interventions have been successful in decreasing gambling, with motivational enhancement therapy (MET) being the most effective. Pharmacological interventions, such as selective serotonin reuptake inhibitors (SSRIs), naltrexone, and mood stabilizers, have also been effective, but the choice of drug depends on the presence of comorbidity. Psychological interventions, particularly cognitive-behavioral treatments, show promise, but long-term follow-up and high drop-out rates are major limitations. Studies comparing psychological and pharmacological interventions are needed.

    • This question is part of the following fields:

      • Substance Misuse/Addictions
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  • Question 42 - A 35-year-old man repeatedly visits his GP due to distress over his physical...

    Correct

    • A 35-year-old man repeatedly visits his GP due to distress over his physical appearance. He believes that his ears are too large and this causes him to constantly check his appearance in the mirror and consider ear surgery. Upon examination, there is no obvious physical abnormality of his ears. You determine that his beliefs are overvalued ideas rather than delusional and there is no evidence of depression.
      What would be your recommended approach for managing his concerns?

      Your Answer: Fluvoxamine + CBT

      Explanation:

      Referral for surgical correction of the deformity is not advisable as it may not address the underlying issue of non-delusional body dysmorphic disorder and the patient may shift their focus to another body part. Instead, treatment options such as SSRIs, clomipramine, and CBT should be considered. Antipsychotics may be more appropriate for delusional BDD.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 43 - How can the correlation between violent recidivism and the items on the VRAG...

    Correct

    • How can the correlation between violent recidivism and the items on the VRAG be ranked in terms of strength?

      Your Answer: PCL-R score

      Explanation:

      The correlation between the PCL-R (Psychopathy Checklist-Revised, also known as Hare Psychopathy Checklist) score and violent recidivism is the strongest.

      Methods of Risk Assessment

      Methods of risk assessment are important in determining the potential harm that an individual may pose to others. There are three main methods for assessing risk to others: unstructured clinical approach, actuarial risk assessment, and structured professional judgment. The unstructured clinical approach is based solely on professional experience and does not involve any specific framework. Actuarial risk assessment uses tools that are based on statistical models of weighted factors supported by research as being predictive for future risk. Structured professional judgment combines professional judgment with a consideration of static and dynamic risk factors. Following this, the risk is formulated, and a plan is devised. There are various tools available for each method, such as the Historical-Clinical-Risk Management-20 (HCR-20) for violence, the Risk of Sexual Violence Protocol (RSVP) for sexual risk, and the Hare Psychopathy Checklist (PCL-R) for violence. It is important to use a multidisciplinary approach and consider all relevant risk factors in the formulation.

    • This question is part of the following fields:

      • Forensic Psychiatry
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  • Question 44 - What is the weekly unit intake of a patient who consumes 3 litres...

    Correct

    • What is the weekly unit intake of a patient who consumes 3 litres of 12% ABV wine per day?

      Your Answer: 252

      Explanation:

      The weekly total is 252 units.

      Alcohol Conversion

      When converting alcohol volume to units, use the equation: Alcohol (units) = Alcohol volume (litres) x Alcohol by volume. For example, if you have 2 liters of cider with 6% alcohol, it is equal to 12 units. Remember to always use this equation to accurately convert alcohol volume to units.

    • This question is part of the following fields:

      • Substance Misuse/Addictions
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  • Question 45 - What factor has been demonstrated to be the most significant indicator of relapse...

    Correct

    • What factor has been demonstrated to be the most significant indicator of relapse in individuals with schizophrenia?

      Your Answer: Non-compliance with treatment

      Explanation:

      Vega (1997) conducted a study that has been replicated multiple times, leading to this discovery.

      Schizophrenia Epidemiology

      Prevalence:
      – In England, the estimated annual prevalence for psychotic disorders (mostly schizophrenia) is around 0.4%.
      – Internationally, the estimated annual prevalence for psychotic disorders is around 0.33%.
      – The estimated lifetime prevalence for psychotic disorders in England is approximately 0.63% at age 43, consistent with the typically reported 1% prevalence over the life course.
      – Internationally, the estimated lifetime prevalence for psychotic disorders is around 0.48%.

      Incidence:
      – In England, the pooled incidence rate for non-affective psychosis (mostly schizophrenia) is estimated to be 15.2 per 100,000 years.
      – Internationally, the incidence of schizophrenia is about 0.20/1000/year.

      Gender:
      – The male to female ratio is 1:1.

      Course and Prognosis:
      – Long-term follow-up studies suggest that after 5 years of illness, one quarter of people with schizophrenia recover completely, and for most people, the condition gradually improves over their lifetime.
      – Schizophrenia has a worse prognosis with onset in childhood of adolescence than with onset in adult life.
      – Younger age of onset predicts a worse outcome.
      – Failure to comply with treatment is a strong predictor of relapse.
      – Over a 2-year period, one-third of patients with schizophrenia showed a benign course, and two-thirds either relapsed of failed to recover.
      – People with schizophrenia have a 2-3 fold increased risk of premature death.

      Winter Births:
      – Winter births are associated with an increased risk of schizophrenia.

      Urbanicity:
      – There is a higher incidence of schizophrenia associated with urbanicity.

      Migration:
      – There is a higher incidence of schizophrenia associated with migration.

      Class:
      – There is a higher prevalence of schizophrenia among lower socioeconomic classes.

      Learning Disability:
      – Prevalence rates for schizophrenia in people with learning disabilities are approximately three times greater than for the general population.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 46 - What is the likelihood of women with bipolar disorder experiencing a relapse during...

    Correct

    • What is the likelihood of women with bipolar disorder experiencing a relapse during the postpartum period?

      Your Answer: 40%

      Explanation:

      Bipolar Disorder in Women of Childbearing Potential

      Prophylaxis is recommended for women with bipolar disorder, as postpartum relapse rates are high. Women without prophylactic pharmacotherapy during pregnancy have a postpartum relapse rate of 66%, compared to 23% for women with prophylaxis. Antipsychotics are recommended for pregnant women with bipolar disorder, according to NICE Guidelines (CG192) and the Maudsley. Women taking valproate, lithium, carbamazepine, of lamotrigine should discontinue treatment and start an antipsychotic, especially if taking valproate. If a woman with bipolar disorder is taking lithium and becomes pregnant, she should gradually stop lithium over a 4 week period and start an antipsychotic. If this is not possible, lithium levels must be taken regularly, and the dose adjusted accordingly. For acute mania, an antipsychotic should be considered. For mild depressive symptoms, self-help approaches, brief psychological interventions, and antidepressant medication can be considered. For moderate to severe depressive symptoms, psychological treatment (CBT) for moderate depression and combined medication and structured psychological interventions for severe depression should be considered.

      Reference: Wesseloo, R., Kamperman, A. M., Munk-Olsen, T., Pop, V. J., Kushner, S. A., & Bergink, V. (2016). Risk of postpartum relapse in bipolar disorder and postpartum psychosis: a systematic review and meta-analysis. The American Journal of Psychiatry, 173(2), 117-127.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 47 - A 25-year-old woman who gave birth 3 days ago comes in for a...

    Correct

    • A 25-year-old woman who gave birth 3 days ago comes in for a consultation as she is worried about her mood. She is experiencing trouble sleeping and feels generally anxious and weepy. Since giving birth, she has also noticed herself being short-tempered with her partner. This is her first pregnancy, she is not nursing, and there is no history of mental health issues in her medical history. What is the best course of action for managing her symptoms?

      Your Answer: Explanation and reassurance

      Explanation:

      It is common for women to experience the baby-blues, which affects approximately two-thirds of them. Although lack of sleep can be a symptom of depression, it is a normal occurrence for new mothers.

      Perinatal Depression, Baby Blues, and Postpartum Depression

      Perinatal depression, also known as postpartum depression, is a common mood disorder experienced by new mothers after childbirth. The term baby blues is used to describe the emotional lability that some mothers experience during the first week after childbirth, which usually resolves by day 10 without treatment. The prevalence of baby blues is around 40%. Postpartum depression, on the other hand, refers to depression that occurs after childbirth. While neither DSM-5 nor ICD-11 specifically mention postpartum depression, both diagnostic systems offer categories that encompass depression during pregnancy of in the weeks following delivery. The prevalence of postpartum depression is approximately 10-15%.

      Various factors have been shown to increase the risk of postnatal depression, including youth, marital and family conflict, lack of social support, anxiety and depression during pregnancy, substance misuse, previous pregnancy loss, ambivalence about the current pregnancy, and frequent antenatal admissions to a maternity hospital. However, obstetric factors such as length of labor, assisted delivery, of separation of the mother from the baby in the Special Care Baby Unit do not seem to influence the development of postnatal depression. Additionally, social class does not appear to be associated with postnatal depression.

      Puerperal psychosis, along with severe depression, is thought to be mainly caused by biological factors, while psychosocial factors are most important in the milder postnatal depressive illnesses.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 48 - What is the most appropriate course of action for a patient with bipolar...

    Correct

    • What is the most appropriate course of action for a patient with bipolar I disorder who has been stable on lithium for many years but has experienced five hypomanic episodes in the past year and is currently presenting with a hypomanic episode?

      Your Answer: Continue the lithium and add olanzapine

      Explanation:

      Based on the case, it appears that the patient is experiencing bipolar I with rapid cycling. According to NICE guidelines, there is no specific treatment recommended for rapid cycling. However, one possible approach would be to add an antipsychotic medication to the patient’s current lithium treatment. Alternatively, the Maudsley Guidelines suggest that combining different mood stabilizers, such as lithium and valproate, may be considered as an alternative treatment option.

      Bipolar Disorder: Diagnosis and Management

      Bipolar disorder is a lifelong condition characterized by episodes of mania or hypomania and episodes of depressed mood. The peak age of onset is 15-19 years, and the lifetime prevalence of bipolar I disorders is estimated to be around 2.1%. The diagnosis of bipolar disorder is based on the presence of manic or hypomanic episodes, which are characterized by elevated of expansive mood, rapid speech, and increased activity of energy. Psychotic symptoms, such as delusions and hallucinations, may also be present.

      Bipolar depression differs from unipolar depression in several ways, including more rapid onset, more frequent episodes, and shorter duration. Rapid cycling is a qualifier that can be applied to bipolar I of bipolar II disorder and is defined as the presence of at least four mood episodes in the previous 12 months that meet the criteria for a manic, hypomanic, of major depressive episode.

      The management of bipolar disorder involves acute and long-term interventions. Acute management of mania or hypomania may involve stopping antidepressants and offering antipsychotics of mood stabilizers. Long-term management may involve psychological interventions and pharmacological treatments such as lithium, valproate, of olanzapine.

      It is important to note that valproate should not be offered to women of girls of childbearing potential for long-term bipolar disorder unless other options are ineffective of not tolerated and a pregnancy prevention program is in place. Aripiprazole is recommended as an option for treating moderate to severe manic episodes in adolescents with bipolar I disorder.

      Overall, the diagnosis and management of bipolar disorder require a comprehensive approach that takes into account the individual’s symptoms, history, and preferences.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 49 - Which antihistamine is most likely to cause delirium in an elderly patient? ...

    Correct

    • Which antihistamine is most likely to cause delirium in an elderly patient?

      Your Answer: Promethazine

      Explanation:

      Delirium is more likely to occur with first generation H1 antihistamines.

      Risk Factors for Delirium

      Delirium is a common condition that affects many elderly individuals. There are several risk factors that can increase the likelihood of developing delirium. These risk factors include age, cognitive impairment, severe medical illness, previous history of delirium of neurological disease, psychoactive drug use, polypharmacy, and anticholinergic drug use.

      Medications are the most common reversible cause of delirium and dementia in the elderly. Certain classes of drugs, such as opioids, benzodiazepines, and anticholinergics, are strongly associated with the development of drug-induced dementia. Long-acting benzodiazepines are more troublesome than shorter-acting ones. Opioids are associated with an approximately 2-fold increased risk of delirium in medical and surgical patients. Pethidine, a member of the opioid class, appears to have a higher risk of delirium compared with other opioids due to its accumulation in individuals with impaired renal function and conversion to a metabolite with anticholinergic properties.

      Overall, it is important to be aware of these risk factors and to carefully monitor medication use in elderly individuals to prevent the development of delirium.

    • This question is part of the following fields:

      • Old Age Psychiatry
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  • Question 50 - What is a true statement about Cotard's syndrome? ...

    Correct

    • What is a true statement about Cotard's syndrome?

      Your Answer: It is most commonly associated with depression

      Explanation:

      Cotard’s syndrome is a delusion where an individual believes they do not exist of have lost their blood, internal organs, of soul. It is commonly seen in depression, schizophrenia, and bipolar disorder, and can also occur after trauma. The condition is more prevalent in females and the elderly.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 51 - The epidemiology of ADHD can be described as follows: ...

    Correct

    • The epidemiology of ADHD can be described as follows:

      Your Answer: The male to female ratio of ADHD in adults is approximately 1.6:1

      Explanation:

      Primary inattentive features are more commonly observed in females with ADHD, as opposed to hyperactivity and impulsivity which are more prevalent in males.

      ADHD is a prevalent disorder worldwide, with a prevalence of 7% in those under 18 and 3.5% in those over 18. It is more common in males, with a male to female ratio of 2:1 in children and 1.6:1 in adults. While some improvement in symptoms is seen over time, the majority of those diagnosed in childhood continue to struggle with residual symptoms and impairments through at least young adulthood, with an estimated persistence rate of 50%.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
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  • Question 52 - A 67-year-old female with a history of dementia is brought in by her...

    Correct

    • A 67-year-old female with a history of dementia is brought in by her family due to an increase in aggressive behavior. She appears to be in good physical health. What is the most suitable treatment for her outbursts of aggression?

      Your Answer: Risperidone

      Explanation:

      Non-drug approaches should be the first line of defense in managing aggression in Alzheimer’s disease, including identifying triggers and utilizing behavioral techniques. However, in some cases, drug treatment may be necessary. Atypical neuroleptics like quetiapine and haloperidol are not recommended due to increased risk of death of stroke and potential cognitive decline. Risperidone is licensed for short-term treatment of persistent aggression in moderate to severe Alzheimer’s disease if non-pharmacological alternatives have been tried and there is a risk of harm. Valproate has been used for calming effects, but evidence of its efficacy is limited. Benzodiazepines are not recommended due to increased risk of falls and worsening cognitive decline.

    • This question is part of the following fields:

      • Old Age Psychiatry
      11.9
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  • Question 53 - What does the term necrophilia refer to in regards to an abnormal sexual...

    Correct

    • What does the term necrophilia refer to in regards to an abnormal sexual preference?

      Your Answer: Corpses

      Explanation:

      Paraphilias are intense and persistent sexual interests other than sexual interest in genital stimulation of preparatory fondling with phenotypically normal, physically mature, consenting human partners. They are divided into those relating to erotic activity and those relating to erotic target. In order to become a disorder, paraphilias must be associated with distress of impairment to the individual of with harm to others. The DSM-5 lists 8 recognised paraphilic disorder but acknowledges that there are many more. Treatment modalities for the paraphilias have limited scientific evidence to support their use. Psychological therapy (especially CBT) is often used (with extremely variable results). Pharmacological options include SSRI, Naltrexone, Antipsychotics, GnRH agonists, and Anti-androgens and progestational drugs (e.g. cyproterone acetate).

    • This question is part of the following fields:

      • Forensic Psychiatry
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  • Question 54 - What was the most common disorder identified in the Epidemiological Catchment Area study?...

    Correct

    • What was the most common disorder identified in the Epidemiological Catchment Area study?

      Your Answer: Substance misuse disorders

      Explanation:

      The most common disorder identified in the study was substance misuse, which encompassed both alcohol and drug use. This finding differs from the National Psychiatric Morbidity Survey, which reported neurotic disorders as the most prevalent. However, this discrepancy is likely due to differences in study design rather than actual differences in prevalence. The ECA study specifically identified high rates of alcohol dependence and illicit drug use, but presented these findings as distinct categories.

      Epidemiological Catchment Area Study: A Landmark Community-Based Survey

      The Epidemiological Catchment Area Study (ECA) was a significant survey conducted in five US communities from 1980-1985. The study included 20,000 participants, with 3000 community residents and 500 residents of institutions sampled in each site. The Diagnostic Interview Schedule (DIS) was used to conduct two interviews over a year with each participant.

      However, the DIS diagnosis of schizophrenia was not consistent with psychiatrists’ classification, with only 20% of cases identified by the DIS in the Baltimore ECA site matching the psychiatrist’s diagnosis. Despite this, the ECA produced valuable findings, including a lifetime prevalence rate of 32.3% for any disorder, 16.4% for substance misuse disorder, 14.6% for anxiety disorder, 8.3% for affective disorder, 1.5% for schizophrenia and schizophreniform disorder, and 0.1% for somatization disorder.

      The ECA also found that phobia had a one-month prevalence of 12.5%, generalized anxiety and depression had a prevalence of 8.5%, obsessive-compulsive disorder had a prevalence of 2.5%, and panic had a prevalence of 1.6%. Overall, the ECA was a landmark community-based survey that provided valuable insights into the prevalence of mental disorders in the US.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 55 - What report aimed to address the disproportionate number of individuals with mental health...

    Correct

    • What report aimed to address the disproportionate number of individuals with mental health issues in English prisons?

      Your Answer: Bradley report

      Explanation:

      The Bradley Report and its Recommendations for Mental Health in the Criminal Justice System

      The Bradley Report was an independent review that aimed to improve the experience of individuals with mental health problems and learning disabilities in the criminal justice system. The report made 82 recommendations for change, including proposals to address the over-representation of people with mental health issues in prisons in England.

      One of the key recommendations was the establishment of a national network of Criminal Justice Mental Health teams. These teams would work to divert individuals towards support services from police stations, courts, and after their release from prison. Additionally, the report called for a maximum wait time of 14 days for individuals who require urgent mental health treatment and need to be transferred from prison to hospital. The NHS was also urged to take on the responsibility of providing health services in police stations.

      Overall, the Bradley Report highlighted the need for significant changes to be made in the criminal justice system to better support individuals with mental health problems and learning disabilities. Its recommendations have the potential to improve the lives of many vulnerable individuals and reduce the number of people with mental health issues in prisons.

    • This question is part of the following fields:

      • Forensic Psychiatry
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  • Question 56 - What is another term used to refer to a type II error in...

    Incorrect

    • What is another term used to refer to a type II error in hypothesis testing?

      Your Answer: True negative

      Correct Answer: False negative

      Explanation:

      Hypothesis testing involves the possibility of two types of errors: type I and type II errors. A type I error occurs when the null hypothesis is wrongly rejected of the alternative hypothesis is wrongly accepted. This error is also referred to as an alpha error, error of the first kind, of a false positive. On the other hand, a type II error occurs when the null hypothesis is wrongly accepted. This error is also known as the beta error, error of the second kind, of the false negative.

      Understanding Hypothesis Testing in Statistics

      In statistics, it is not feasible to investigate hypotheses on entire populations. Therefore, researchers take samples and use them to make estimates about the population they are drawn from. However, this leads to uncertainty as there is no guarantee that the sample taken will be truly representative of the population, resulting in potential errors. Statistical hypothesis testing is the process used to determine if claims from samples to populations can be made and with what certainty.

      The null hypothesis (Ho) is the claim that there is no real difference between two groups, while the alternative hypothesis (H1 of Ha) suggests that any difference is due to some non-random chance. The alternative hypothesis can be one-tailed of two-tailed, depending on whether it seeks to establish a difference of a change in one direction.

      Two types of errors may occur when testing the null hypothesis: Type I and Type II errors. Type I error occurs when the null hypothesis is rejected when it is true, while Type II error occurs when the null hypothesis is accepted when it is false. The power of a study is the probability of correctly rejecting the null hypothesis when it is false, and it can be increased by increasing the sample size.

      P-values provide information on statistical significance and help researchers decide if study results have occurred due to chance. The p-value is the probability of obtaining a result that is as large of larger when in reality there is no difference between two groups. The cutoff for the p-value is called the significance level (alpha level), typically set at 0.05. If the p-value is less than the cutoff, the null hypothesis is rejected, and if it is greater or equal to the cut off, the null hypothesis is not rejected. However, the p-value does not indicate clinical significance, which may be too small to be meaningful.

    • This question is part of the following fields:

      • Research Methods, Statistics, Critical Review And Evidence-Based Practice
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  • Question 57 - What is the most likely diagnosis for a 10 year old boy who...

    Correct

    • What is the most likely diagnosis for a 10 year old boy who is exhibiting aggressive and destructive behavior at home and school, including fighting with other children and attempting to harm animals?

      Your Answer: Conduct disorder

      Explanation:

      It is not possible to diagnose Antisocial (dissocial) personality disorder in children.

      Disruptive Behaviour of Dissocial Disorders

      Conduct disorders are the most common reason for referral of young children to mental health services. These disorders are characterized by a repetitive and persistent pattern of antisocial, aggressive, of defiant conduct that goes beyond ordinary childish mischief of adolescent rebelliousness. Oppositional defiant disorder (ODD) shares some negative attributes but in a more limited fashion.

      ICD-11 terms the disorder as ‘Conduct-dissocial disorder’, while DSM-5 recognizes three separate conditions related to emotional/behavioral problems seen in younger people: conduct disorder, oppositional defiant disorder, and intermittent explosive disorder. Conduct disorder is about poorly controlled behavior, intermittent explosive disorder is about poorly controlled emotions, and ODD is in between. Conduct disorders are further divided into childhood onset (before 10 years) and adolescent onset (10 years of older).

      The behavior pattern of conduct disorders must be persistent and recurrent, including multiple incidents of aggression towards people of animals, destruction of property, deceitfulness of theft, and serious violations of rules. The pattern of behavior must result in significant impairment in personal, family, social, educational, occupational, of other important areas of functioning.

      Oppositional defiant disorder represents a less severe form of conduct disorder, where there is an absence of more severe dissocial of aggressive acts. The behavior pattern of ODD includes persistent difficulty getting along with others, provocative, spiteful, of vindictive behavior, and extreme irritability of anger.

      The prevalence of conduct disorders increases throughout childhood and is more common in boys than girls. The most frequent comorbid problem seen with conduct disorder is hyperactivity. The conversion rate from childhood conduct disorder to adult antisocial personality disorder varies from 40 to 70% depending on the study.

      NICE recommends group parent-based training programs of parent and child training programs for children with complex needs for ages 3-11, child-focused programs for ages 9-14, and multimodal interventions with a family focus for ages 11-17. Medication is not recommended in routine practice, but risperidone can be used where other approaches fail and they are seriously aggressive.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
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  • Question 58 - Which statement accurately describes the evidence supporting the use of lithium? ...

    Incorrect

    • Which statement accurately describes the evidence supporting the use of lithium?

      Your Answer: Lithium has not been shown to be effective at protecting against antidepressant induced hypomania.

      Correct Answer: Lithium has been shown to be an effective augmentation agent for people with unipolar depression

      Explanation:

      Lithium – Clinical Usage

      Lithium is primarily used as a prophylactic agent for bipolar disorder, where it reduces the severity and number of relapses. It is also effective as an augmentation agent in unipolar depression and for treating aggressive and self-mutilating behavior, steroid-induced psychosis, and to raise WCC in people using clozapine.

      Before prescribing lithium, renal, cardiac, and thyroid function should be checked, along with a Full Blood Count (FBC) and BMI. Women of childbearing age should be advised regarding contraception, and information about toxicity should be provided.

      Once daily administration is preferred, and various preparations are available. Abrupt discontinuation of lithium increases the risk of relapse, and if lithium is to be discontinued, the dose should be reduced gradually over a period of at least 4 weeks.

      Inadequate monitoring of patients taking lithium is common, and it is often an exam hot topic. Lithium salts have a narrow therapeutic/toxic ratio, and samples should ideally be taken 12 hours after the dose. The target range for prophylaxis is 0.6–0.75 mmol/L.

      Risk factors for lithium toxicity include drugs altering renal function, decreased circulating volume, infections, fever, decreased oral intake of water, renal insufficiency, and nephrogenic diabetes insipidus. Features of lithium toxicity include GI and neuro symptoms.

      The severity of toxicity can be assessed using the AMDISEN rating scale.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 59 - Which of the options below does not belong to the group of neo-Freudians?...

    Correct

    • Which of the options below does not belong to the group of neo-Freudians?

      Your Answer: Burrhus Skinner

      Explanation:

      B.F. Skinner, a prominent figure in the field of psychology, is renowned for his contributions to the theory of reinforcement within the behaviourist perspective.

      Neo-Freudians were therapists who developed their own theories while still retaining core Freudian components. Some important neo-Freudians include Alfred Adler, Carl Jung, Erik Erickson, Harry Stack Sullivan, Wilfred Bion, John Bowlby, Anna Freud, Otto Kernberg, Margaret Mahler, and Donald Winnicott. Each of these individuals contributed unique ideas to the field of psychology. For example, Carl Jung introduced the concept of the persona and differentiated between the personal and collective unconscious, while Erik Erickson is known for his stages of psychosocial development. Margaret Mahler developed theories on child development, including the three main phases of autistic, symbiotic, and separation-individuation. Donald Winnicott introduced the concept of the transitional object and the good enough mother. Overall, neo-Freudians expanded upon Freud’s ideas and helped to shape modern psychotherapy.

    • This question is part of the following fields:

      • Psychotherapy
      7
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  • Question 60 - Which of the following factors is not associated with an increased risk of...

    Incorrect

    • Which of the following factors is not associated with an increased risk of developing schizophrenia?

      Your Answer: Urban living

      Correct Answer: Old maternal age

      Explanation:

      Schizophrenia is associated with advanced paternal age, as well as cannabis use, which is a separate risk factor (Rajiv, 2008; Semple, 2005).

      Schizophrenia Epidemiology

      Prevalence:
      – In England, the estimated annual prevalence for psychotic disorders (mostly schizophrenia) is around 0.4%.
      – Internationally, the estimated annual prevalence for psychotic disorders is around 0.33%.
      – The estimated lifetime prevalence for psychotic disorders in England is approximately 0.63% at age 43, consistent with the typically reported 1% prevalence over the life course.
      – Internationally, the estimated lifetime prevalence for psychotic disorders is around 0.48%.

      Incidence:
      – In England, the pooled incidence rate for non-affective psychosis (mostly schizophrenia) is estimated to be 15.2 per 100,000 years.
      – Internationally, the incidence of schizophrenia is about 0.20/1000/year.

      Gender:
      – The male to female ratio is 1:1.

      Course and Prognosis:
      – Long-term follow-up studies suggest that after 5 years of illness, one quarter of people with schizophrenia recover completely, and for most people, the condition gradually improves over their lifetime.
      – Schizophrenia has a worse prognosis with onset in childhood of adolescence than with onset in adult life.
      – Younger age of onset predicts a worse outcome.
      – Failure to comply with treatment is a strong predictor of relapse.
      – Over a 2-year period, one-third of patients with schizophrenia showed a benign course, and two-thirds either relapsed of failed to recover.
      – People with schizophrenia have a 2-3 fold increased risk of premature death.

      Winter Births:
      – Winter births are associated with an increased risk of schizophrenia.

      Urbanicity:
      – There is a higher incidence of schizophrenia associated with urbanicity.

      Migration:
      – There is a higher incidence of schizophrenia associated with migration.

      Class:
      – There is a higher prevalence of schizophrenia among lower socioeconomic classes.

      Learning Disability:
      – Prevalence rates for schizophrenia in people with learning disabilities are approximately three times greater than for the general population.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 61 - How can a patient's history indicate the presence of mania instead of hypomania?...

    Correct

    • How can a patient's history indicate the presence of mania instead of hypomania?

      Your Answer: Auditory hallucinations

      Explanation:

      While psychotic symptoms such as delusions and hallucinations can manifest during mania, they are not a requirement for diagnosis. Hypomania, on the other hand, is a milder form of mania that does not involve psychotic symptoms.

      Bipolar Disorder Diagnosis

      Bipolar and related disorders are mood disorders characterized by manic, mixed, of hypomanic episodes alternating with depressive episodes. The lifetime risk of suicide in individuals with bipolar disorder is estimated to be at least 15 times that of the general population. Under the ICD-11, there are three subtypes of bipolar disorder: Bipolar I, Bipolar II, and Cyclothymic disorder.

      Bipolar I disorder is diagnosed when an individual has a history of at least one manic of mixed episode. The typical course of the disorder is characterized by recurrent depressive and manic of mixed episodes. Onset of the first mood episode most often occurs during the late teen years, but onset of bipolar type I can occur at any time through the life cycle. The lifetime prevalence of bipolar I disorder is estimated to be around 2.1%.

      Bipolar II disorder is diagnosed when an individual has a history of at least one hypomanic episode and at least one depressive episode. The typical course of the disorder is characterized by recurrent depressive and hypomanic episodes. Onset of bipolar type II most often occurs during the mid-twenties. The number of lifetime episodes tends to be higher for bipolar II disorder than for major depressive disorder of bipolar I disorder.

      Cyclothymic disorder is diagnosed when an individual experiences mood instability over an extended period of time characterized by numerous hypomanic and depressive periods. The symptoms are present for more days than not, and there is no history of manic or mixed episodes. The course of cyclothymic disorder is often gradual and persistent, and onset commonly occurs during adolescence of early adulthood.

      Rapid cycling is not a subtype of bipolar disorder but instead is a qualifier. It is defined as the presence of at least four mood episodes in the previous 12 months that meet the criteria for a manic, hypomanic, of major depressive episode. Rapid cycling is associated with an increased risk of suicide and tends to be precipitated by stressors such as life events, alcohol abuse, use of antidepressants, and medical disorders.

      Overall, the diagnosis of bipolar disorder requires careful evaluation of an individual’s symptoms and history. Treatment typically involves a combination of medication and psychotherapy.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 62 - What is the term used by Freud to describe the process of discharging...

    Correct

    • What is the term used by Freud to describe the process of discharging aggressive impulses?

      Your Answer: Catharsis

      Explanation:

      Aggression – Freud

      According to Freud, aggression is a result of the primary instinct called thanatos, also known as the death instinct. He believed that every individual possesses this drive, which aims to cause complete destruction and death. Additionally, Freud proposed the existence of an opposing instinct called eros, which is the life instinct. He also introduced the concept of catharsis, which is a process of releasing libidinal energy and inducing a sense of calmness. This process occurs when we witness an aggressive act of engage in a mildly aggressive act.

    • This question is part of the following fields:

      • Psychotherapy
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  • Question 63 - What therapy is founded on Otto Kernberg's idea of 'borderline personality organization'? ...

    Correct

    • What therapy is founded on Otto Kernberg's idea of 'borderline personality organization'?

      Your Answer: Transference focused psychotherapy

      Explanation:

      Personality Disorder (Borderline)

      History and Terminology

      The term borderline personality disorder originated from early 20th-century theories that the disorder was on the border between neurosis and psychosis. The term borderline was coined by Adolph Stern in 1938. Subsequent attempts to define the condition include Otto Kernberg’s borderline personality organization, which identified key elements such as ego weakness, primitive defense mechanisms, identity diffusion, and unstable reality testing.

      Features

      The DSM-5 and ICD-11 both define borderline personality disorder as a pervasive pattern of instability in interpersonal relationships, self-image, and affects, and marked impulsivity. Symptoms include efforts to avoid abandonment, unstable relationships, impulsivity, suicidal behavior, affective instability, chronic feelings of emptiness, difficulty controlling temper, and transient dissociative symptoms.

      Abuse

      Childhood abuse and neglect are extremely common among borderline patients, with up to 87% having suffered some form of trauma. The effect of abuse seems to depend on the stage of psychological development at which it takes place.

      comorbidity

      Borderline PD patients are more likely to receive a diagnosis of major depressive disorder, bipolar disorder, panic disorder, PTSD, OCD, eating disorders, and somatoform disorders.

      Psychological Therapy

      Dialectical Behavioral Therapy (DBT), Mentalization-Based Treatment (MBT), Schema-Focused Therapy (SFT), and Transference-Focused Psychotherapy (TFP) are the main psychological treatments for BPD. DBT is the most well-known and widely available, while MBT focuses on improving mentalization, SFT generates structural changes to a patient’s personality, and TFP examines dysfunctional interpersonal dynamics that emerge in interactions with the therapist in the transference.

      NICE Guidelines

      The NICE guidelines on BPD offer very little recommendations. They do not recommend medication for treatment of the core symptoms. Regarding psychological therapies, they make reference to DBT and MBT being effective but add that the evidence base is too small to draw firm conclusions. They do specifically say Do not use brief psychotherapeutic interventions (of less than 3 months’ duration) specifically for borderline personality disorder of for the individual symptoms of the disorder.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 64 - Which of the following traits does not align with the diagnosis of dependent...

    Incorrect

    • Which of the following traits does not align with the diagnosis of dependent personality disorder?

      Your Answer: Difficulty in expressing disagreement with others due to fears of losing support

      Correct Answer: Excessive need for admiration and acclaim

      Explanation:

      Narcissistic personality disorder may be indicated by an excessive desire for admiration.

      Dependent Personality Disorder is a type of personality disorder where individuals excessively rely on others for support and fear abandonment. This disorder falls under Cluster C personality disorders. The DSM-5 criteria for this disorder includes exhibiting five of more of the following behaviors: difficulty making decisions without input from others, requiring others to take on responsibilities, fear of disagreement, difficulty starting projects without support, excessive need for nurturance and support, feeling vulnerable and helpless when alone, seeking new relationships when one ends, and having an unrealistic fear of being left alone and unable to care for oneself. The ICD-11 removed the specific diagnosis of Dependent Personality Disorder, but individuals can still be diagnosed with a general personality disorder if they exhibit dependent features.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 65 - What is a true statement about opioid withdrawal? ...

    Correct

    • What is a true statement about opioid withdrawal?

      Your Answer: Withdrawal symptoms may develop upon abrupt discontinuation of opioids after 5 days of regular and uninterrupted opioid use

      Explanation:

      The fact that even brief periods of opiate use can lead to withdrawal symptoms highlights the addictive nature of these drugs.

      Opioid Maintenance Therapy and Detoxification

      Withdrawal symptoms can occur after as little as 5 days of regular opioid use. Short-acting opioids like heroin have acute withdrawal symptoms that peak in 32-72 hours and last for 3-5 days. Longer-acting opioids like methadone have acute symptoms that peak at day 4-6 and last for 10 days. Buprenorphine withdrawal lasts up to 10 days and includes symptoms like myalgia, anxiety, and increased drug craving.

      Opioids affect the brain through opioid receptors, with the µ receptor being the main target for opioids. Dopaminergic cells in the ventral tegmental area produce dopamine, which is released into the nucleus accumbens upon stimulation of µ receptors, producing euphoria and reward. With repeat opioid exposure, µ receptors become less responsive, causing dysphoria and drug craving.

      Methadone and buprenorphine are maintenance-oriented treatments for opioid dependence. Methadone is a full agonist targeting µ receptors, while buprenorphine is a partial agonist targeting µ receptors and a partial k agonist of functional antagonist. Naloxone and naltrexone are antagonists targeting all opioid receptors.

      Methadone is preferred over buprenorphine for detoxification, and ultra-rapid detoxification should not be offered. Lofexidine may be considered for mild of uncertain dependence. Clonidine and dihydrocodeine should not be used routinely in opioid detoxification. The duration of detoxification should be up to 4 weeks in an inpatient setting and up to 12 weeks in a community setting.

      Pregnant women dependent on opioids should use opioid maintenance treatment rather than attempt detoxification. Methadone is preferred over buprenorphine, and transfer to buprenorphine during pregnancy is not advised. Detoxification should only be considered if appropriate for the women’s wishes, circumstances, and ability to cope. Methadone or buprenorphine treatment is not a contraindication to breastfeeding.

    • This question is part of the following fields:

      • Substance Misuse/Addictions
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  • Question 66 - Which statement accurately describes mentally disordered offenders? ...

    Incorrect

    • Which statement accurately describes mentally disordered offenders?

      Your Answer: The prevalence of epilepsy among prisoners is higher than in the general population

      Correct Answer:

      Explanation:

      There are several possible reasons why the prevalence of epilepsy is higher among prisoners compared to the general population. One explanation is that an underlying organic mental disorder may be responsible for both epilepsy and offending. Another possibility is that the development of epilepsy can negatively impact an individual’s self-esteem and lead to social rejection, which may then result in antisocial behavior. Additionally, adverse social circumstances may contribute to both epilepsy and antisocial behavior. Finally, a tendency towards impulsivity and antisocial behavior may lead to brain injuries and subsequent post-traumatic epilepsy.

      Offending by the Mentally Disordered

      The prevalence of epilepsy is higher among prisoners than in the general population, but this does not necessarily mean that they are more likely to be serving a custodial sentence for violence. Matricide, the killing of one’s mother, is often associated with schizophrenia, although not always. Othello’s syndrome, a delusional jealousy that usually affects men in their 40s after about 10 years of marriage, can be difficult to treat with antipsychotic medication and may require separation from the spouse. Depressive disorder is more commonly associated with suicide, but in some cases, it can lead to homicide, particularly in the morning and involving family members.

    • This question is part of the following fields:

      • Forensic Psychiatry
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  • Question 67 - Which term is used to refer to the alternative hypothesis in hypothesis testing?...

    Correct

    • Which term is used to refer to the alternative hypothesis in hypothesis testing?

      a) Research hypothesis
      b) Statistical hypothesis
      c) Simple hypothesis
      d) Null hypothesis
      e) Composite hypothesis

      Your Answer: Research hypothesis

      Explanation:

      Understanding Hypothesis Testing in Statistics

      In statistics, it is not feasible to investigate hypotheses on entire populations. Therefore, researchers take samples and use them to make estimates about the population they are drawn from. However, this leads to uncertainty as there is no guarantee that the sample taken will be truly representative of the population, resulting in potential errors. Statistical hypothesis testing is the process used to determine if claims from samples to populations can be made and with what certainty.

      The null hypothesis (Ho) is the claim that there is no real difference between two groups, while the alternative hypothesis (H1 of Ha) suggests that any difference is due to some non-random chance. The alternative hypothesis can be one-tailed of two-tailed, depending on whether it seeks to establish a difference of a change in one direction.

      Two types of errors may occur when testing the null hypothesis: Type I and Type II errors. Type I error occurs when the null hypothesis is rejected when it is true, while Type II error occurs when the null hypothesis is accepted when it is false. The power of a study is the probability of correctly rejecting the null hypothesis when it is false, and it can be increased by increasing the sample size.

      P-values provide information on statistical significance and help researchers decide if study results have occurred due to chance. The p-value is the probability of obtaining a result that is as large of larger when in reality there is no difference between two groups. The cutoff for the p-value is called the significance level (alpha level), typically set at 0.05. If the p-value is less than the cutoff, the null hypothesis is rejected, and if it is greater or equal to the cut off, the null hypothesis is not rejected. However, the p-value does not indicate clinical significance, which may be too small to be meaningful.

    • This question is part of the following fields:

      • Research Methods, Statistics, Critical Review And Evidence-Based Practice
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  • Question 68 - What is the accurate statement about the structural model of the mind? ...

    Incorrect

    • What is the accurate statement about the structural model of the mind?

      Your Answer: The ego is completely conscious

      Correct Answer: The Superego contains the ego ideal

      Explanation:

      The Superego encompasses the ‘ego ideal’, which embodies exemplary attitudes and conduct. One can liken the Superego to a moral compass of conscience.

      Freud’s Structural Theory: Understanding the Three Areas of the Mind

      According to Freud’s structural model, the human mind is divided into three distinct areas: the Id, the Ego, and the Superego. The Id is the part of the mind that contains instinctive drives and operates on the ‘pleasure principle’. It functions without a sense of time and is governed by ‘primary process thinking’. The Ego, on the other hand, attempts to modify the drives from the Id with external reality. It operates on the ‘reality principle’ and has conscious, preconscious, and unconscious aspects. It is also home to the defense mechanisms. Finally, the Superego acts as a critical agency, constantly observing a person’s behavior. Freud believed that it developed from the internalized values of a child’s main caregivers. The Superego contains the ‘ego ideal’, which represents ideal attitudes and behavior. It is often referred to as the conscience. Understanding these three areas of the mind is crucial to understanding Freud’s structural theory.

    • This question is part of the following fields:

      • Psychotherapy
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  • Question 69 - What is the estimated percentage of individuals in Great Britain who have a...

    Correct

    • What is the estimated percentage of individuals in Great Britain who have a personality disorder?

      Your Answer: 4.40%

      Explanation:

      Personality Disorder: Understanding the Clinical Diagnosis

      A personality disorder is a long-standing pattern of behavior and inner experience that deviates significantly from cultural expectations, is inflexible and pervasive, and causes distress of impairment. The DSM-5 and ICD-11 have different approaches to classifying personality disorders. DSM-5 divides them into 10 categories, while ICD-11 has a general category with six trait domains that can be added. To diagnose a personality disorder, clinicians must first establish that the general diagnostic threshold is met before identifying the subtype(s) present. The course of personality disorders varies, with some becoming less evident of remitting with age, while others persist.

      DSM-5 and ICD-11 have different classification systems for personality disorders. DSM-5 divides them into three clusters (A, B, and C), while ICD-11 has a general category with six trait domains that can be added. The prevalence of personality disorders in Great Britain is 4.4%, with Cluster C being the most common. Clinicians are advised to avoid diagnosing personality disorders in children, although a diagnosis can be made in someone under 18 if the features have been present for at least a year (except for antisocial personality disorder).

      Overall, understanding the clinical diagnosis of personality disorders is important for effective treatment and management of these conditions.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 70 - What is the best course of action regarding medication for a woman with...

    Correct

    • What is the best course of action regarding medication for a woman with bipolar disorder who is 6 weeks pregnant and wishes to continue the pregnancy while being stable on valproate for several years?

      Your Answer: Stop the valproate and offer an antipsychotic for prophylaxis

      Explanation:

      Valproate is a potent teratogen and should ideally be discontinued during pregnancy. However, the decision to stop must be carefully weighed against the risk of relapse, which is high in some cases. If the history suggests mild to moderate illness, continuing valproate may not be supported. In such cases, NICE Guidelines recommend stopping valproate and starting an antipsychotic as prophylaxis. Pregnancy is a high-risk period for bipolar relapse, so stopping valproate without replacing it with an antipsychotic would be unwise. A shared decision-making approach should be used to determine the best course of action. (Macfarlane, 2018)

      Bipolar Disorder in Women of Childbearing Potential

      Prophylaxis is recommended for women with bipolar disorder, as postpartum relapse rates are high. Women without prophylactic pharmacotherapy during pregnancy have a postpartum relapse rate of 66%, compared to 23% for women with prophylaxis. Antipsychotics are recommended for pregnant women with bipolar disorder, according to NICE Guidelines (CG192) and the Maudsley. Women taking valproate, lithium, carbamazepine, of lamotrigine should discontinue treatment and start an antipsychotic, especially if taking valproate. If a woman with bipolar disorder is taking lithium and becomes pregnant, she should gradually stop lithium over a 4 week period and start an antipsychotic. If this is not possible, lithium levels must be taken regularly, and the dose adjusted accordingly. For acute mania, an antipsychotic should be considered. For mild depressive symptoms, self-help approaches, brief psychological interventions, and antidepressant medication can be considered. For moderate to severe depressive symptoms, psychological treatment (CBT) for moderate depression and combined medication and structured psychological interventions for severe depression should be considered.

      Reference: Wesseloo, R., Kamperman, A. M., Munk-Olsen, T., Pop, V. J., Kushner, S. A., & Bergink, V. (2016). Risk of postpartum relapse in bipolar disorder and postpartum psychosis: a systematic review and meta-analysis. The American Journal of Psychiatry, 173(2), 117-127.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 71 - Which statistical test is best suited for analyzing the difference in blood pressure...

    Incorrect

    • Which statistical test is best suited for analyzing the difference in blood pressure between the two groups of patients who were given either the established of new anti-hypertensive medication in a randomized controlled trial with a crossover design?

      Your Answer: Unpaired t-test

      Correct Answer: Paired t-test

      Explanation:

      The appropriate statistical test to analyze the research question of the difference between two related groups with a dependent variable of change in BP (ratio) and parametric data is a paired t-test.

      Choosing the right statistical test can be challenging, but understanding the basic principles can help. Different tests have different assumptions, and using the wrong one can lead to inaccurate results. To identify the appropriate test, a flow chart can be used based on three main factors: the type of dependent variable, the type of data, and whether the groups/samples are independent of dependent. It is important to know which tests are parametric and non-parametric, as well as their alternatives. For example, the chi-squared test is used to assess differences in categorical variables and is non-parametric, while Pearson’s correlation coefficient measures linear correlation between two variables and is parametric. T-tests are used to compare means between two groups, and ANOVA is used to compare means between more than two groups. Non-parametric equivalents to ANOVA include the Kruskal-Wallis analysis of ranks, the Median test, Friedman’s two-way analysis of variance, and Cochran Q test. Understanding these tests and their assumptions can help researchers choose the appropriate statistical test for their data.

    • This question is part of the following fields:

      • Research Methods, Statistics, Critical Review And Evidence-Based Practice
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  • Question 72 - A study reports that 76 percent of the subjects receiving fluvoxamine versus 29...

    Correct

    • A study reports that 76 percent of the subjects receiving fluvoxamine versus 29 percent of the placebo group were treatment responders. Based on this data, what is the number needed to treat?

      Your Answer: 2.12

      Explanation:

      To determine the number needed to treat (NNT), we first calculated the absolute risk reduction (ARR) using the formula ARR = CER – EER, where CER is the control event rate and EER is the experimental event rate. In this case, the ARR was 0.47, which is the reciprocal of the NNT. Therefore, the NNT was calculated as 2.12. This means that for every two patients treated with the active medication, at least one patient will have a better outcome compared to those treated with a placebo.

      Measures of Effect in Clinical Studies

      When conducting clinical studies, we often want to know the effect of treatments of exposures on health outcomes. Measures of effect are used in randomized controlled trials (RCTs) and include the odds ratio (of), risk ratio (RR), risk difference (RD), and number needed to treat (NNT). Dichotomous (binary) outcome data are common in clinical trials, where the outcome for each participant is one of two possibilities, such as dead of alive, of clinical improvement of no improvement.

      To understand the difference between of and RR, it’s important to know the difference between risks and odds. Risk is a proportion that describes the probability of a health outcome occurring, while odds is a ratio that compares the probability of an event occurring to the probability of it not occurring. Absolute risk is the basic risk, while risk difference is the difference between the absolute risk of an event in the intervention group and the absolute risk in the control group. Relative risk is the ratio of risk in the intervention group to the risk in the control group.

      The number needed to treat (NNT) is the number of patients who need to be treated for one to benefit. Odds are calculated by dividing the number of times an event happens by the number of times it does not happen. The odds ratio is the odds of an outcome given a particular exposure versus the odds of an outcome in the absence of the exposure. It is commonly used in case-control studies and can also be used in cross-sectional and cohort study designs. An odds ratio of 1 indicates no difference in risk between the two groups, while an odds ratio >1 indicates an increased risk and an odds ratio <1 indicates a reduced risk.

    • This question is part of the following fields:

      • Research Methods, Statistics, Critical Review And Evidence-Based Practice
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  • Question 73 - What is the most probable condition of a patient referred by cardiologists who...

    Correct

    • What is the most probable condition of a patient referred by cardiologists who persists in believing that he has heart disease despite multiple normal tests and reassurances from several cardiologists?

      Your Answer: Hypochondriacal disorder

      Explanation:

      There is often confusion between hypochondriasis and somatisation disorder, which have been renamed illness anxiety disorder and somatic symptom disorder in the DSM-5. Hypochondriasis involves a preoccupation with a specific condition, while somatisation disorder is characterized by a focus on symptoms rather than a particular illness.

      Somatoform and dissociative disorders are two groups of psychiatric disorders that are characterized by physical symptoms and disruptions in the normal integration of identity, sensations, perceptions, affects, thoughts, memories, control over bodily movements, of behavior. Somatoform disorders are characterized by physical symptoms that are presumed to have a psychiatric origin, while dissociative disorders are characterized by the loss of integration between memories, identity, immediate sensations, and control of bodily movements. The ICD-11 lists two main types of somatoform disorders: bodily distress disorder and body integrity dysphoria. Dissociative disorders include dissociative neurological symptom disorder, dissociative amnesia, trance disorder, possession trance disorder, dissociative identity disorder, partial dissociative identity disorder, depersonalization-derealization disorder, and other specified dissociative disorders. The symptoms of these disorders result in significant impairment in personal, family, social, educational, occupational, of other important areas of functioning. Diagnosis of these disorders involves a thorough evaluation of the individual’s symptoms and medical history, as well as ruling out other possible causes of the symptoms.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 74 - What term is commonly used in reference to the type of therapy offered...

    Correct

    • What term is commonly used in reference to the type of therapy offered to dysfunctional families known as strategic family therapy?

      Your Answer: Task setting

      Explanation:

      Family Therapy Models

      Family therapy emerged in the 1950s, shifting the focus from individual problems to the context of the environment. There are five main models of family therapy: structural, strategic, systemic, transgenerational, and solution-focused.

      Structural therapy, developed by Salvador Minuchin, assumes that the family’s structure is wrong and aims to establish clear boundaries and no coalitions. Dysfunctional families are marked by impaired boundaries, inappropriate alignments, and power imbalances.

      Strategic therapy, associated with Jay Haley and Cloe Madanes, claims that difficulties in families arise due to distorted hierarchies. Dysfunctional families communicate in problematic repetitive patterns that kept them dysfunctional. Key terms include task setting and goal setting.

      Systemic therapy, associated with Mara Selvini-Palazzoli, sees the family as a self-regulating system that controls itself according to rules formed over time. The focus is on exploring differences between family members’ behaviors, emotional responses, and beliefs at different points in time. Key terms include hypothesizing, neutrality, positive connotation, paradox and counterparadox, circular and interventive questioning, and the use of reflecting teams.

      Transgenerational family therapy aims to understand how families, across generations, develop patterns of behaving and responding to stress in ways that prevent health development and lead to problems. Seven interlocking concepts make up the theory.

      Solution-focused therapy emphasizes solutions over problems and collaborates with the family through in-depth questioning to focus on the solutions already being used by the clients. The therapist is non-interventionist, and the focus is on the present and the future. Blame, shame, and conflict are seen as issues that impede people from realizing these solutions.

    • This question is part of the following fields:

      • Psychotherapy
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  • Question 75 - In this case, a 23-year-old woman with autism spectrum disorder and attention deficit...

    Correct

    • In this case, a 23-year-old woman with autism spectrum disorder and attention deficit hyperactivity disorder is seeking advice on medication options for her attention deficit hyperactivity disorder. She has reported using CBD oil occasionally to help her feel more relaxed in social situations, but denies any substance misuse. The most suitable initial medication choice in this situation would be:

      Your Answer: Methylphenidate

      Explanation:

      According to Graham (2011), the use of cannabis of CBD does not automatically prevent the prescription of stimulant medication for ADHD. Methylphenidate is considered the most effective treatment option and would be the preferred choice. Atomoxetine may be used if there is a concern about stimulant abuse of diversion, but in this case, there is no evidence of substance misuse. These recommendations are based on European guidelines for managing adverse effects of medication for ADHD.

      ADHD Diagnosis and Management in Adults

      ADHD is a behavioural syndrome characterised by symptoms of inattention, hyperactivity, and impulsivity. The DSM-5 and ICD-11 provide diagnostic criteria for ADHD, with the DSM-5 recognising three subtypes of the condition: predominantly inattentive, predominantly hyperactive-impulsive, and combined.

      Treatment for ADHD in adults includes medication and non-pharmacological interventions. NICE recommends offering medication to adults with ADHD if their symptoms are still causing significant impairment after environmental modifications have been implemented and reviewed. Methylphenidate of lisdexamfetamine are first-line medications, with atomoxetine offered for those who cannot tolerate the former two. Additional medication options may be considered with advice from a tertiary ADHD service.

      NICE advises against elimination diets, dietary fatty acid supplementation, and the use of the ‘few foods diet’ for ADHD. Prior to initiating medication, referral to cardiology is recommended if there is a suggestion of cardiac pathology. If a person with ADHD develops mania of psychosis, ADHD treatment should be stopped until the episode has resolved. If a person taking stimulants develops tics, medication options may be adjusted.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 76 - How can confounding be controlled during the analysis stage of a study? ...

    Correct

    • How can confounding be controlled during the analysis stage of a study?

      Your Answer: Stratification

      Explanation:

      Stratification is a method of managing confounding by dividing the data into two or more groups where the confounding variable remains constant of varies minimally.

      Types of Bias in Statistics

      Bias is a systematic error that can lead to incorrect conclusions. Confounding factors are variables that are associated with both the outcome and the exposure but have no causative role. Confounding can be addressed in the design and analysis stage of a study. The main method of controlling confounding in the analysis phase is stratification analysis. The main methods used in the design stage are matching, randomization, and restriction of participants.

      There are two main types of bias: selection bias and information bias. Selection bias occurs when the selected sample is not a representative sample of the reference population. Disease spectrum bias, self-selection bias, participation bias, incidence-prevalence bias, exclusion bias, publication of dissemination bias, citation bias, and Berkson’s bias are all subtypes of selection bias. Information bias occurs when gathered information about exposure, outcome, of both is not correct and there was an error in measurement. Detection bias, recall bias, lead time bias, interviewer/observer bias, verification and work-up bias, Hawthorne effect, and ecological fallacy are all subtypes of information bias.

    • This question is part of the following fields:

      • Research Methods, Statistics, Critical Review And Evidence-Based Practice
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  • Question 77 - How would you describe the behavior of a child who complains of stomach...

    Correct

    • How would you describe the behavior of a child who complains of stomach pains when taken to school but appears fine and eager to learn and play when allowed to stay at home?

      Your Answer: School refusal

      Explanation:

      Understanding School Refusal

      School refusal is a common problem that affects 1-5% of children, with similar rates in both boys and girls. Although it can occur at any age, it is more common in children aged five, six, 10, and 11 years. Unlike truancy, school refusal is not a formal diagnosis and is characterized by severe distress about attending school, often manifesting as temper tantrums and somatic symptoms. Parents are generally aware of the absence, and there is no antisocial behavior present. Children with school refusal often have a desire and willingness to do school work at home, whereas those who are truant show little interest in school work in any setting.

      The onset of school refusal symptoms is usually gradual and may occur after a holiday of illness. Stressful events at home of school, of with peers, may also cause school refusal. Presenting symptoms include fearfulness, panic symptoms, crying episodes, temper tantrums, threats of self-harm, and somatic symptoms that present in the morning and improve if the child is allowed to stay home.

      Behavioural approaches, primarily exposure-based treatments, are used to treat school refusal. However, it is important to note that school refusal is not a diagnosis but a presenting problem that may be linked to other diagnoses such as separation anxiety disorder, generalized anxiety disorder, depression, oppositional defiant disorder, learning disorders, and pervasive developmental disabilities such as Asperger’s disorder, autism, and mental retardation.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
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  • Question 78 - A teenager prescribed clozapine for schizophrenia develops depression and is given an SSRI....

    Correct

    • A teenager prescribed clozapine for schizophrenia develops depression and is given an SSRI. Three days after starting the new tablets they have a seizure and are admitted to hospital. What is the most probable cause of the seizure?

      Your Answer: Fluoxetine

      Explanation:

      When taken with clozapine, many SSRIs can cause an increase in its levels. However, citalopram and escitalopram are considered safe as they do not affect the cytochrome system. Although paroxetine is believed to interact, it has been proven safe when used at normal clinical doses alongside clozapine. Sertraline has minimal impact on clozapine levels.

      Interactions of Antidepressants with Cytochrome P450 System

      Antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), can have significant effects on the cytochrome P450 system. This can result in drug interactions that can affect the efficacy and safety of the medications.

      One example of such interaction is between fluvoxamine and theophylline. Fluvoxamine is a potent inhibitor of CYP1A2, which can lead to increased levels of theophylline in the body. This can cause adverse effects such as nausea, vomiting, and tremors.

      Another example is between fluoxetine and clozapine. Fluoxetine is a potent inhibitor of CYP2D6, which can increase the risk of seizures with clozapine. Clozapine is metabolized by CYP1A2, CYP3A4, and CYP2D6, and any inhibition of these enzymes can affect its metabolism and increase the risk of adverse effects.

      It is important to be aware of these interactions and monitor patients closely when prescribing antidepressants, especially in those who are taking other medications that are metabolized by the cytochrome P450 system.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 79 - Which model of family therapy is linked to the concepts of 'hierarchy', 'boundaries',...

    Incorrect

    • Which model of family therapy is linked to the concepts of 'hierarchy', 'boundaries', and 'coalitions'?

      Your Answer: Systemic

      Correct Answer: Structural

      Explanation:

      Family Therapy Models

      Family therapy emerged in the 1950s, shifting the focus from individual problems to the context of the environment. There are five main models of family therapy: structural, strategic, systemic, transgenerational, and solution-focused.

      Structural therapy, developed by Salvador Minuchin, assumes that the family’s structure is wrong and aims to establish clear boundaries and no coalitions. Dysfunctional families are marked by impaired boundaries, inappropriate alignments, and power imbalances.

      Strategic therapy, associated with Jay Haley and Cloe Madanes, claims that difficulties in families arise due to distorted hierarchies. Dysfunctional families communicate in problematic repetitive patterns that kept them dysfunctional. Key terms include task setting and goal setting.

      Systemic therapy, associated with Mara Selvini-Palazzoli, sees the family as a self-regulating system that controls itself according to rules formed over time. The focus is on exploring differences between family members’ behaviors, emotional responses, and beliefs at different points in time. Key terms include hypothesizing, neutrality, positive connotation, paradox and counterparadox, circular and interventive questioning, and the use of reflecting teams.

      Transgenerational family therapy aims to understand how families, across generations, develop patterns of behaving and responding to stress in ways that prevent health development and lead to problems. Seven interlocking concepts make up the theory.

      Solution-focused therapy emphasizes solutions over problems and collaborates with the family through in-depth questioning to focus on the solutions already being used by the clients. The therapist is non-interventionist, and the focus is on the present and the future. Blame, shame, and conflict are seen as issues that impede people from realizing these solutions.

    • This question is part of the following fields:

      • Psychotherapy
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  • Question 80 - Which model of the mind is composed of the fundamental elements of the...

    Correct

    • Which model of the mind is composed of the fundamental elements of the Id, ego, and Superego?

      Your Answer: Structural

      Explanation:

      Freud’s Structural Theory: Understanding the Three Areas of the Mind

      According to Freud’s structural model, the human mind is divided into three distinct areas: the Id, the Ego, and the Superego. The Id is the part of the mind that contains instinctive drives and operates on the ‘pleasure principle’. It functions without a sense of time and is governed by ‘primary process thinking’. The Ego, on the other hand, attempts to modify the drives from the Id with external reality. It operates on the ‘reality principle’ and has conscious, preconscious, and unconscious aspects. It is also home to the defense mechanisms. Finally, the Superego acts as a critical agency, constantly observing a person’s behavior. Freud believed that it developed from the internalized values of a child’s main caregivers. The Superego contains the ‘ego ideal’, which represents ideal attitudes and behavior. It is often referred to as the conscience. Understanding these three areas of the mind is crucial to understanding Freud’s structural theory.

    • This question is part of the following fields:

      • Psychotherapy
      5
      Seconds
  • Question 81 - What is the term used to describe the inability of limitation to perform...

    Correct

    • What is the term used to describe the inability of limitation to perform an activity within the typical range expected for a human being?

      Your Answer: Disability

      Explanation:

      Understanding Learning Disabilities: Key Terms to Know

      Learning disabilities can be complex and challenging to understand. To help make sense of this topic, it’s important to be familiar with some key terms. Two important terms to know are impairments and disability.

      Impairments refer to problems in body function and structure, such as significant deviation of loss. This can include difficulties with vision, hearing, mobility, of cognitive functioning. Impairments can impact a person’s ability to learn and participate in daily activities.

      Disability is an umbrella term that encompasses impairments, activity limitations, and participation restrictions. It refers to the negative aspects of the interaction between a person’s health condition(s) and their contextual factors, including environmental and personal factors. For example, a person with a learning disability may experience difficulty with reading, writing, of math, which can impact their ability to participate fully in school of work.

      Understanding these terms can help individuals better understand the challenges faced by those with learning disabilities and work towards creating more inclusive and supportive environments.

    • This question is part of the following fields:

      • Learning Disability
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  • Question 82 - What is the estimated minimum unit price for alcohol that could prevent 624...

    Incorrect

    • What is the estimated minimum unit price for alcohol that could prevent 624 deaths and 237,000 hospital admissions annually in England?

      Your Answer: 50 pence

      Correct Answer: 45 pence

      Explanation:

      According to a study conducted by the University of Sheffield, implementing a minimum unit price of 45 pence for alcohol could potentially save 624 lives and prevent 237,000 hospital admissions in England every year. Additionally, the research suggests that the ban on selling alcohol below cost, which was implemented in May 2014, could prevent 14 deaths and 500 hospital admissions annually.

    • This question is part of the following fields:

      • Organisation And Delivery Of Psychiatric Services
      10.8
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  • Question 83 - Which brain region experiences increased neuronal activity leading to symptoms like yawning, abdominal...

    Correct

    • Which brain region experiences increased neuronal activity leading to symptoms like yawning, abdominal cramps, and goosebumps during opioid withdrawal?

      Your Answer: Locus coeruleus

      Explanation:

      Opioid Maintenance Therapy and Detoxification

      Withdrawal symptoms can occur after as little as 5 days of regular opioid use. Short-acting opioids like heroin have acute withdrawal symptoms that peak in 32-72 hours and last for 3-5 days. Longer-acting opioids like methadone have acute symptoms that peak at day 4-6 and last for 10 days. Buprenorphine withdrawal lasts up to 10 days and includes symptoms like myalgia, anxiety, and increased drug craving.

      Opioids affect the brain through opioid receptors, with the µ receptor being the main target for opioids. Dopaminergic cells in the ventral tegmental area produce dopamine, which is released into the nucleus accumbens upon stimulation of µ receptors, producing euphoria and reward. With repeat opioid exposure, µ receptors become less responsive, causing dysphoria and drug craving.

      Methadone and buprenorphine are maintenance-oriented treatments for opioid dependence. Methadone is a full agonist targeting µ receptors, while buprenorphine is a partial agonist targeting µ receptors and a partial k agonist of functional antagonist. Naloxone and naltrexone are antagonists targeting all opioid receptors.

      Methadone is preferred over buprenorphine for detoxification, and ultra-rapid detoxification should not be offered. Lofexidine may be considered for mild of uncertain dependence. Clonidine and dihydrocodeine should not be used routinely in opioid detoxification. The duration of detoxification should be up to 4 weeks in an inpatient setting and up to 12 weeks in a community setting.

      Pregnant women dependent on opioids should use opioid maintenance treatment rather than attempt detoxification. Methadone is preferred over buprenorphine, and transfer to buprenorphine during pregnancy is not advised. Detoxification should only be considered if appropriate for the women’s wishes, circumstances, and ability to cope. Methadone or buprenorphine treatment is not a contraindication to breastfeeding.

    • This question is part of the following fields:

      • Substance Misuse/Addictions
      13.5
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  • Question 84 - A 60-year-old construction worker presents to the hospital with complaints of muscle aches,...

    Correct

    • A 60-year-old construction worker presents to the hospital with complaints of muscle aches, poor memory, and malaise for the past four weeks. During the physical examination, a 5 cm well-defined lesion is observed on the right flank. What is the most probable diagnosis?

      Your Answer: Lyme Disease

      Explanation:

      Lyme disease, which is caused by ticks carrying the infection (Lyme borreliosis), is typically found in the Northern Hemisphere. A distinctive ‘bulls-eye’ rash appears in around two thirds of patients.
      Although the symptoms of Lyme disease can be vague, other conditions such as Chronic Fatigue Syndrome, hypothyroidism and SLE may be considered as possible diagnoses. The crucial factor in identifying Lyme disease is the presence of the characteristic skin lesion.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 85 - Which statement accurately reflects the relationship between migration and the risk of developing...

    Incorrect

    • Which statement accurately reflects the relationship between migration and the risk of developing schizophrenia?

      Your Answer: First generation migrants are at a higher risk of developing schizophrenia than second generation migrants

      Correct Answer: The relative risk for developing schizophrenia among second-generation migrants is 4.5

      Explanation:

      The risk of obstetric complications is about twice as high in individuals with schizophrenia compared to those without the condition.

      Schizophrenia and Migration: A Meta-Analysis and Review

      Migration is a significant risk factor for the development of schizophrenia, according to a comprehensive review of the topic. The study found that the mean weighted relative risk for first-generation migrants was 2.7, while the relative risk for second-generation migrants was 4.5. When analyzing both first- and second-generation migrants, the relative risk was 2.9. The study also found that migrants from developing countries and areas with a majority black population had significantly greater effect sizes. These findings highlight the importance of considering migration status when assessing risk for schizophrenia.

    • This question is part of the following fields:

      • General Adult Psychiatry
      28.1
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  • Question 86 - What is a true statement about the NICE Guidelines concerning self-harm in young...

    Incorrect

    • What is a true statement about the NICE Guidelines concerning self-harm in young individuals?

      Your Answer: Interventions for self-harm should not involve psychodynamic approaches

      Correct Answer: All children who have overdosed on opioids should be taken to hospital

      Explanation:

      Self-harm is a common issue among young people, particularly girls, with rates appearing to have risen over the past decade. It is most likely to occur between the ages of 12 and 15 years and is associated with a range of psychiatric problems. Short-term management involves a psychosocial assessment and consideration of activated charcoal for drug overdose. Longer-term management may involve psychological interventions, but drug treatment should not be offered as a specific intervention to reduce self-harm. Risk assessment tools should not be used to predict future suicide of repetition of self-harm, but certain factors such as male gender, substance misuse, and parental mental disorder may be associated with a higher risk of completed suicide. It is important to seek professional help if you of someone you know is engaging in self-harm.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
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  • Question 87 - Which medication is most likely to reduce the effectiveness of the oral contraceptive...

    Correct

    • Which medication is most likely to reduce the effectiveness of the oral contraceptive pill?

      Your Answer: Carbamazepine

      Explanation:

      Mood stabilisers and contraception: Some anticonvulsants/mood stabilisers can interfere with contraception, such as carbamazepine, phenytoin, and topiramate. However, others like valproate, lamotrigine, gabapentin, and lithium do not tend to cause this problem and are preferred for women using contraception. It is important to note that valproate should only be used in girls and women of childbearing potential if other treatments are ineffective of not tolerated, as judged by an experienced specialist. Additionally, valproate is contraindicated in girls and women of childbearing potential unless the conditions of the valproate pregnancy prevention programme (‘prevent’) are met.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 88 - What is the primary treatment option for catatonia? ...

    Correct

    • What is the primary treatment option for catatonia?

      Your Answer: Lorazepam

      Explanation:

      When treating catatonia, the preferred initial treatment is benzodiazepines such as lorazepam. If this approach is unsuccessful, electroconvulsive therapy (ECT) should be considered.

      Catatonia Treatment

      Catatonia can lead to complications such as dehydration, deep vein thrombosis, pulmonary embolism, and pneumonia. Therefore, prompt treatment is essential. The first-line treatment is benzodiazepines, particularly lorazepam. If this is ineffective, electroconvulsive therapy (ECT) may be considered. The use of antipsychotics is controversial and should be avoided during the acute phase of catatonia.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 89 - What is a true statement about Kleine-Levin syndrome? ...

    Correct

    • What is a true statement about Kleine-Levin syndrome?

      Your Answer: It is associated with hyperphagia

      Explanation:

      Kleine-Levin Syndrome: A Mysterious Condition

      Kleine-Levin syndrome is a peculiar disorder that typically affects adolescent boys. It is characterized by an excessive need for sleep and an insatiable appetite when awake. The condition is also associated with emotional and behavioral issues such as irritability and aggression.

      The onset of symptoms is sudden and can last for several days to weeks before disappearing. This is followed by a period of normalcy, only to be followed by another episode. This pattern can continue for years, but the severity of symptoms tends to decrease over time. During the periods between episodes, those affected appear to be perfectly healthy with no signs of physical of behavioral dysfunction. The media has dubbed this condition as Sleeping Beauty syndrome.

      Despite extensive research, the cause of Kleine-Levin syndrome remains unknown. However, the prognosis is generally positive, with most individuals making a full recovery.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
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  • Question 90 - Based on the AUCs shown below, which screening test had the highest overall...

    Correct

    • Based on the AUCs shown below, which screening test had the highest overall performance in differentiating between the presence of absence of bulimia?

      Test - AUC
      Test 1 - 0.42
      Test 2 - 0.95
      Test 3 - 0.82
      Test 4 - 0.11
      Test 5 - 0.67

      Your Answer: Test 2

      Explanation:

      Understanding ROC Curves and AUC Values

      ROC (receiver operating characteristic) curves are graphs used to evaluate the effectiveness of a test in distinguishing between two groups, such as those with and without a disease. The curve plots the true positive rate against the false positive rate at different threshold settings. The goal is to find the best trade-off between sensitivity and specificity, which can be adjusted by changing the threshold. AUC (area under the curve) is a measure of the overall performance of the test, with higher values indicating better accuracy. The conventional grading of AUC values ranges from excellent to fail. ROC curves and AUC values are useful in evaluating diagnostic and screening tools, comparing different tests, and studying inter-observer variability.

    • This question is part of the following fields:

      • Research Methods, Statistics, Critical Review And Evidence-Based Practice
      80.2
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  • Question 91 - What is a true statement about bodily distress disorder? ...

    Correct

    • What is a true statement about bodily distress disorder?

      Your Answer: Prevalence is higher in females

      Explanation:

      Children experience a particular symptom more frequently than adults do.

      Somatoform and dissociative disorders are two groups of psychiatric disorders that are characterized by physical symptoms and disruptions in the normal integration of identity, sensations, perceptions, affects, thoughts, memories, control over bodily movements, of behavior. Somatoform disorders are characterized by physical symptoms that are presumed to have a psychiatric origin, while dissociative disorders are characterized by the loss of integration between memories, identity, immediate sensations, and control of bodily movements. The ICD-11 lists two main types of somatoform disorders: bodily distress disorder and body integrity dysphoria. Dissociative disorders include dissociative neurological symptom disorder, dissociative amnesia, trance disorder, possession trance disorder, dissociative identity disorder, partial dissociative identity disorder, depersonalization-derealization disorder, and other specified dissociative disorders. The symptoms of these disorders result in significant impairment in personal, family, social, educational, occupational, of other important areas of functioning. Diagnosis of these disorders involves a thorough evaluation of the individual’s symptoms and medical history, as well as ruling out other possible causes of the symptoms.

    • This question is part of the following fields:

      • General Adult Psychiatry
      21.5
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  • Question 92 - The patient inquires about the likelihood of developing neutropenia while taking clozapine. What...

    Incorrect

    • The patient inquires about the likelihood of developing neutropenia while taking clozapine. What is the estimated risk of neutropenia associated with the use of clozapine?

      Your Answer: 1%

      Correct Answer: 3%

      Explanation:

      Clozapine is an effective antipsychotic drug used in the management of treatment-resistant schizophrenia (TRS). It was reintroduced in the 1990s with mandatory blood monitoring due to the risk of agranulocyte

    • This question is part of the following fields:

      • General Adult Psychiatry
      5.4
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  • Question 93 - As a healthcare AI language model, I cannot provide medical advice of recommendations....

    Correct

    • As a healthcare AI language model, I cannot provide medical advice of recommendations. It is important to consult with a qualified healthcare professional who can assess the patient's individual needs and medical history to determine the best course of treatment.

      Your Answer: Olanzapine

      Explanation:

      One of the notable side effects of olanzapine is its potential to induce diabetes.

      Antipsychotics: Common Side Effects and Relative Adverse Effects

      Antipsychotics are medications used to treat various mental health conditions, including schizophrenia and bipolar disorder. However, they can also cause side effects that can be bothersome of even serious. The most common side effects of antipsychotics are listed in the table below, which includes the adverse effects associated with their receptor activity.

      Antidopaminergic effects: These effects are related to the medication’s ability to block dopamine receptors in the brain. They can cause galactorrhoea, gynecomastia, menstrual disturbance, lowered sperm count, reduced libido, Parkinsonism, dystonia, akathisia, and tardive dyskinesia.

      Anticholinergic effects: These effects are related to the medication’s ability to block acetylcholine receptors in the brain. They can cause dry mouth, blurred vision, urinary retention, and constipation.

      Antiadrenergic effects: These effects are related to the medication’s ability to block adrenaline receptors in the body. They can cause postural hypotension and ejaculatory failure.

      Histaminergic effects: These effects are related to the medication’s ability to block histamine receptors in the brain. They can cause drowsiness.

      The Maudsley Guidelines provide a rough guide to the relative adverse effects of different antipsychotics. The table below summarizes their findings, with +++ indicating a high incidence of adverse effects, ++ indicating a moderate incidence, + indicating a low incidence, and – indicating a very low incidence.

      Drug Sedation Weight gain Diabetes EPSE Anticholinergic Postural Hypotension Prolactin elevation
      Amisulpride – + + + – – +++
      Aripiprazole – +/- – +/- – – –
      Asenapine + + +/- +/- – – +/-
      Clozapine +++ +++ +++ – +++ +++ –
      Flupentixol + ++ + ++ ++ + +++
      Fluphenazine + + + +++ ++ + +++
      Haloperidol + + +/- +++ + + +++
      Olanzapine ++ +++ +++ +/- + + +
      Paliperidone + ++ + + + ++ +++
      Pimozide + + – + + + +++
      Quetiapine ++ ++ ++ – + ++ –
      Risperidone + ++ + + + ++ +++
      Zuclopenthixol ++ ++ + ++ ++ + +++

      Overall, it is important to discuss the potential side effects of antipsychotics with a healthcare provider and to monitor for any adverse effects while taking these medications.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 94 - What percentage of individuals aged 16 years and older in the UK are...

    Incorrect

    • What percentage of individuals aged 16 years and older in the UK are considered to be harmful drinkers?

      Your Answer: 20%

      Correct Answer: 4%

      Explanation:

      Out of the population aged 16 of over, 19% do not consume alcohol, while 60% have a low risk pattern of alcohol consumption. 17% have an increased risk pattern, and 4% have a higher risk pattern, according to the classification of alcohol consumption based on weekly units.

    • This question is part of the following fields:

      • Organisation And Delivery Of Psychiatric Services
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  • Question 95 - What is the recommended minimum dose of olanzapine for a patient experiencing a...

    Correct

    • What is the recommended minimum dose of olanzapine for a patient experiencing a relapse of schizophrenia?

      Your Answer: 7.5 mg

      Explanation:

      Antipsychotics: Minimum Effective Doses

      The Maudsley Guidelines provide a table of minimum effective oral doses for antipsychotics in schizophrenia. The following doses are recommended for first episode and relapse (multi-episode) cases:

      – Chlorpromazine: 200mg (first episode) and 300mg (relapse)
      – Haloperidol: 2mg (first episode) and 4mg (relapse)
      – Sulpiride: 400mg (first episode) and 800mg (relapse)
      – Trifluoperazine: 10mg (first episode) and 15mg (relapse)
      – Amisulpride: 300mg (first episode) and 400mg (relapse)
      – Aripiprazole: 10mg (first episode and relapse)
      – Olanzapine: 5mg (first episode) and 7.5mg (relapse)
      – Quetiapine: 150mg (first episode) and 300mg (relapse)
      – Risperidone: 2mg (first episode) and 4mg (relapse)

      The minimum effective doses may vary depending on individual patient factors and response to treatment. It is important to consult with a healthcare professional before making any changes to medication dosages.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 96 - Which of the following is not a common problem associated with ADHD? ...

    Correct

    • Which of the following is not a common problem associated with ADHD?

      Your Answer: Seizures

      Explanation:

      While there is a potential connection between seizures and ADHD, it is not a confirmed link. The prompt is inquiring about prevalent issues.

      ADHD: Common Associated Problems

      ADHD is often accompanied by a range of problems that can affect a person’s daily life. These problems include non-compliant behavior, motor tics, mood swings, sleep disturbance, aggression, temper tantrums, learning difficulties, unpopularity with peers, and clumsiness. These issues can make it challenging for individuals with ADHD to navigate social situations, perform well in school of work, and maintain healthy relationships. It is essential to seek professional help to manage these associated problems and improve the quality of life for those with ADHD.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
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  • Question 97 - What is the maximum duration of psychotic symptoms required for a diagnosis of...

    Incorrect

    • What is the maximum duration of psychotic symptoms required for a diagnosis of acute and transient psychotic disorder according to the ICD-11?

      Your Answer: 1 month

      Correct Answer: 3 months

      Explanation:

      – Schizophrenia and other primary psychotic disorders are characterized by impairments in reality testing and alterations in behavior.
      – Schizophrenia is a chronic mental health disorder with symptoms including delusions, hallucinations, disorganized speech of behavior, and impaired cognitive ability.
      – The essential features of schizophrenia include persistent delusions, persistent hallucinations, disorganized thinking, experiences of influence, passivity of control, negative symptoms, grossly disorganized behavior, and psychomotor disturbances.
      – Schizoaffective disorder is diagnosed when all diagnostic requirements for schizophrenia are met concurrently with mood symptoms that meet the diagnostic requirements of a moderate or severe depressive episode, a manic episode, of a mixed episode.
      – Schizotypal disorder is an enduring pattern of unusual speech, perceptions, beliefs, and behaviors that are not of sufficient intensity of duration to meet the diagnostic requirements of schizophrenia, schizoaffective disorder, of delusional disorder.
      – Acute and transient psychotic disorder is characterized by an acute onset of psychotic symptoms, which can include delusions, hallucinations, disorganized thinking, of experiences of influence, passivity of control, that emerge without a prodrome, progressing from a non-psychotic state to a clearly psychotic state within 2 weeks.
      – Delusional disorder is diagnosed when there is a presence of a delusion of set of related delusions, typically persisting for at least 3 months and often much longer, in the absence of a depressive, manic, of mixed episode.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 98 - What is the relationship between cannabis use and the likelihood of developing schizophrenia?...

    Correct

    • What is the relationship between cannabis use and the likelihood of developing schizophrenia?

      Your Answer: The younger a person starts using cannabis the higher their subsequent risk

      Explanation:

      Consistent evidence suggests a link between cannabis use and schizophrenia risk, with the risk increasing as the age of first use decreases.

      Schizophrenia and Cannabis Use

      The relationship between cannabis use and the risk of developing schizophrenia is a topic of ongoing debate. However, research suggests that cannabis use may increase the risk of later schizophrenia of schizophreniform disorder by two-fold (Arseneault, 2004). The risk of developing schizophrenia appears to be higher in individuals who start using cannabis at a younger age. For instance, regular cannabis smokers at the age of 15 are 4.5 times more likely to develop schizophrenia at the age of 26, compared to those who did not report regular use until age 18 (Murray, 2004).

      A systematic review published in the Lancet in 2007 found that the lifetime risk of developing psychosis increased by 40% in individuals who had ever used cannabis (Moore, 2007). Another meta-analysis reported that the age at onset of psychosis was 2.70 years younger in cannabis users than in non-users (Large, 2011). These findings suggest that cannabis use may have a significant impact on the development of schizophrenia and related disorders.

    • This question is part of the following fields:

      • Substance Misuse/Addictions
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  • Question 99 - Which of the following is another term for the average of squared deviations...

    Correct

    • Which of the following is another term for the average of squared deviations from the mean?

      Your Answer: Variance

      Explanation:

      The variance can be expressed as the mean of the squared differences between each value and the mean.

      Measures of dispersion are used to indicate the variation of spread of a data set, often in conjunction with a measure of central tendency such as the mean of median. The range, which is the difference between the largest and smallest value, is the simplest measure of dispersion. The interquartile range, which is the difference between the 3rd and 1st quartiles, is another useful measure. Quartiles divide a data set into quarters, and the interquartile range can provide additional information about the spread of the data. However, to get a more representative idea of spread, measures such as the variance and standard deviation are needed. The variance gives an indication of how much the items in the data set vary from the mean, while the standard deviation reflects the distribution of individual scores around their mean. The standard deviation is expressed in the same units as the data set and can be used to indicate how confident we are that data points lie within a particular range. The standard error of the mean is an inferential statistic used to estimate the population mean and is a measure of the spread expected for the mean of the observations. Confidence intervals are often presented alongside sample results such as the mean value, indicating a range that is likely to contain the true value.

    • This question is part of the following fields:

      • Research Methods, Statistics, Critical Review And Evidence-Based Practice
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  • Question 100 - What is the most common method of suicide in England? ...

    Correct

    • What is the most common method of suicide in England?

      Your Answer: Hanging

      Explanation:

      2021 National Confidential Inquiry into Suicide and Safety in Mental Health (NCISH) report reveals key findings on suicide rates in the UK from 2008-2018. The rates have remained stable over the years, with a slight increase following the 2008 recession and another rise since 2015/2016. Approximately 27% of all general population suicides were patients who had contact with mental health services within 12 months of suicide. The most common methods of suicide were hanging/strangulation (52%) and self-poisoning (22%), mainly through prescription opioids. In-patient suicides have continued to decrease, with most of them occurring on the ward itself from low lying ligature points. The first three months after discharge remain a high-risk period, with 13% of all patient suicides occurring within this time frame. Nearly half (48%) of patient suicides were from patients who lived alone. In England, suicide rates are higher in males (17.2 per 100,000) than females (5.4 per 100,000), with the highest age-specific suicide rate for males in the 45-49 years age group (27.1 deaths per 100,000 males) and for females in the same age group (9.2 deaths per 100,000). Hanging remains the most common method of suicide in the UK, accounting for 59.4% of all suicides among males and 45.0% of all suicides among females.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 101 - What factor is most likely to trigger a seizure in a patient with...

    Correct

    • What factor is most likely to trigger a seizure in a patient with epilepsy?

      Your Answer: Amitriptyline

      Explanation:

      Out of the given options, Amitriptyline (TCA) is classified as high risk while the others are categorized as either moderate of low risk.

      Psychotropics and Seizure Threshold in People with Epilepsy

      People with epilepsy are at an increased risk for various mental health conditions, including depression, anxiety, psychosis, and suicide. It is important to note that the link between epilepsy and mental illness is bidirectional, as patients with mental health conditions also have an increased risk of developing new-onset epilepsy. Psychotropic drugs are often necessary for people with epilepsy, but they can reduce the seizure threshold and increase the risk of seizures. The following tables provide guidance on the seizure risk associated with different classes of antidepressants, antipsychotics, and ADHD medications. It is important to use caution and carefully consider the risks and benefits of these medications when treating people with epilepsy.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 102 - A woman initially seen by the nurse practitioner presented with low mood, and...

    Correct

    • A woman initially seen by the nurse practitioner presented with low mood, and insomnia, and was commenced on reboxetine 4 mg BD without any benefit. You assess and confirmed she actually suffers from obsessive compulsive disorder, what will be the appropriate treatment?

      Your Answer: Citalopram

      Explanation:

      The recommended first-line medication for treating OCD in adults is an SSRI.

      Maudsley Guidelines

      First choice: SSRI of clomipramine (SSRI preferred due to tolerability issues with clomipramine)

      Second line:

      – SSRI + antipsychotic
      – Citalopram + clomipramine
      – Acetylcysteine + (SSRI of clomipramine)
      – Lamotrigine + SSRI
      – Topiramate + SSRI

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 103 - Which statement accurately describes antisocial personality disorder? ...

    Incorrect

    • Which statement accurately describes antisocial personality disorder?

      Your Answer: According to the DSM-5 a person must be 17 before they can be diagnosed

      Correct Answer: The term antisocial personality disorder is used in the DSM-5

      Explanation:

      Personality Disorder (Antisocial / Dissocial)

      Antisocial personality disorder is characterized by impulsive, irresponsible, and often criminal behavior. The criteria for this disorder differ somewhat between the ICD-11 and DSM-5. The ICD-11 abolished all categories of personality disorder except for a general description of personality disorder. This diagnosis can be further specified as “mild,” “moderate,” of “severe.” Patient behavior can be described using one of more of five personality trait domains; negative affectivity, dissociality, anankastic, detachment, and disinhibition. Clinicians may also specify a borderline pattern qualifier.

      The core feature of dissociality is a disregard for the rights and feelings of others, encompassing both self-centeredness and lack of empathy. Common manifestations of Dissociality include self-centeredness and lack of empathy. The DSM-5 defines antisocial personality disorder as a pervasive pattern of disregard for and violation of the rights of others, occurring since age 15, as indicated by three (of more) of the following: failure to conform to social norms with respect to lawful behaviors, deceitfulness, impulsivity of failure to plan ahead, irritability and aggressiveness, reckless disregard for safety of self of others, consistent irresponsibility, and lack of remorse.

      Prevalence estimates are between 1%-6% in men and between 0.2-0.8% in women. Antisocial behaviors typically have their onset before age 8 years. Nearly 80% of people with ASPD developed their first symptom by age 11 years. Boys develop symptoms earlier than girls, who may not develop symptoms until puberty. An estimated 25% of girls and 40% of boys with Conduct Disorder will later meet criteria for ASPD.

      The 2009 NICE Guidelines essentially make two recommendations on treatment: consider offering group-based cognitive and behavioral interventions and pharmacological interventions should not be routinely used for the treatment of antisocial personality disorder of associated behaviors of aggression, anger, and impulsivity. A Cochrane review found that there is not enough good quality evidence to recommend of reject any psychological treatment for people with a diagnosis of AsPD.

      The term psychopathy has varied meanings. Some use the term synonymously with APD and consider it to represent the severe end of the spectrum of APD. Others maintain a clear distinction between psychopathy and APD. Psychopathy has been said to be a richer (broader) concept than APD. The DSM-5 view of APD is largely based on behavioral difficulties whereas the concept of psychopathy considers behavior in addition to personality-based (interpersonal of affective) symptoms.

    • This question is part of the following fields:

      • Forensic Psychiatry
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  • Question 104 - A team of scientists aims to perform a systematic review and meta-analysis of...

    Correct

    • A team of scientists aims to perform a systematic review and meta-analysis of the environmental impacts and benefits of using solar energy in residential homes. They want to investigate how their findings would be affected by potential future changes, such as an increase in the cost of solar panels of a shift in government policies promoting renewable energy. What type of analysis should they undertake to address this inquiry?

      Your Answer: Sensitivity analysis

      Explanation:

      A sensitivity analysis is a tool utilized to evaluate the degree to which the outcomes of a study of systematic review are influenced by modifications in the methodology employed. It is employed to determine the resilience of the findings to uncertain judgments of assumptions regarding the data and techniques employed.

    • This question is part of the following fields:

      • Research Methods, Statistics, Critical Review And Evidence-Based Practice
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  • Question 105 - A 30 year old patient needs medication for opiate withdrawal, during a regular...

    Correct

    • A 30 year old patient needs medication for opiate withdrawal, during a regular physical check-up it is discovered that they have a significantly low blood pressure.

      What should be avoided in this case?

      Your Answer: Lofexidine

      Explanation:

      Opioid Maintenance Therapy and Detoxification

      Withdrawal symptoms can occur after as little as 5 days of regular opioid use. Short-acting opioids like heroin have acute withdrawal symptoms that peak in 32-72 hours and last for 3-5 days. Longer-acting opioids like methadone have acute symptoms that peak at day 4-6 and last for 10 days. Buprenorphine withdrawal lasts up to 10 days and includes symptoms like myalgia, anxiety, and increased drug craving.

      Opioids affect the brain through opioid receptors, with the µ receptor being the main target for opioids. Dopaminergic cells in the ventral tegmental area produce dopamine, which is released into the nucleus accumbens upon stimulation of µ receptors, producing euphoria and reward. With repeat opioid exposure, µ receptors become less responsive, causing dysphoria and drug craving.

      Methadone and buprenorphine are maintenance-oriented treatments for opioid dependence. Methadone is a full agonist targeting µ receptors, while buprenorphine is a partial agonist targeting µ receptors and a partial k agonist of functional antagonist. Naloxone and naltrexone are antagonists targeting all opioid receptors.

      Methadone is preferred over buprenorphine for detoxification, and ultra-rapid detoxification should not be offered. Lofexidine may be considered for mild of uncertain dependence. Clonidine and dihydrocodeine should not be used routinely in opioid detoxification. The duration of detoxification should be up to 4 weeks in an inpatient setting and up to 12 weeks in a community setting.

      Pregnant women dependent on opioids should use opioid maintenance treatment rather than attempt detoxification. Methadone is preferred over buprenorphine, and transfer to buprenorphine during pregnancy is not advised. Detoxification should only be considered if appropriate for the women’s wishes, circumstances, and ability to cope. Methadone or buprenorphine treatment is not a contraindication to breastfeeding.

    • This question is part of the following fields:

      • Substance Misuse/Addictions
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  • Question 106 - What is typically avoided during alcohol withdrawal because of the increased likelihood of...

    Correct

    • What is typically avoided during alcohol withdrawal because of the increased likelihood of respiratory depression?

      Your Answer: Clomethiazole

      Explanation:

      Alcohol withdrawal is characterized by overactivity of the autonomic nervous system, resulting in symptoms such as agitation, tremors, sweating, nausea, vomiting, fever, and tachycardia. These symptoms typically begin 3-12 hours after drinking stops, peak between 24-48 hours, and can last up to 14 days. Withdrawal seizures may occur before blood alcohol levels reach zero, and a small percentage of people may experience delirium tremens (DT), which can be fatal if left untreated. Risk factors for DT include abnormal liver function, old age, severity of withdrawal symptoms, concurrent medical illness, heavy alcohol use, self-detox, previous history of DT, low potassium, low magnesium, and thiamine deficiency.

      Pharmacologically assisted detox is often necessary for those who regularly consume more than 15 units of alcohol per day, and inpatient detox may be needed for those who regularly consume more than 30 units per day. The Clinical Institute Withdrawal Assessment of Alcohol Scale (CIWA-Ar) can be used to assess the severity of withdrawal symptoms and guide treatment decisions. Benzodiazepines are the mainstay of treatment, as chronic alcohol exposure results in decreased overall brain excitability and compensatory decrease of GABA-A neuroreceptor response to GABA. Chlordiazepoxide is a good first-line agent, while oxazepam, temazepam, and lorazepam are useful in patients with liver disease. Clomethiazole is effective but carries a high risk of respiratory depression and is not recommended. Thiamine should be offered to prevent Wernicke’s encephalopathy, and long-acting benzodiazepines can be used as prophylaxis for withdrawal seizures. Haloperidol is the treatment of choice if an antipsychotic is required.

    • This question is part of the following fields:

      • Substance Misuse/Addictions
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  • Question 107 - Which statement about disease rates is incorrect? ...

    Incorrect

    • Which statement about disease rates is incorrect?

      Your Answer: The terms risk ratio and relative risk are synonymous

      Correct Answer: The odds ratio is synonymous with the risk ratio

      Explanation:

      Disease Rates and Their Interpretation

      Disease rates are a measure of the occurrence of a disease in a population. They are used to establish causation, monitor interventions, and measure the impact of exposure on disease rates. The attributable risk is the difference in the rate of disease between the exposed and unexposed groups. It tells us what proportion of deaths in the exposed group were due to the exposure. The relative risk is the risk of an event relative to exposure. It is calculated by dividing the rate of disease in the exposed group by the rate of disease in the unexposed group. A relative risk of 1 means there is no difference between the two groups. A relative risk of <1 means that the event is less likely to occur in the exposed group, while a relative risk of >1 means that the event is more likely to occur in the exposed group. The population attributable risk is the reduction in incidence that would be observed if the population were entirely unexposed. It can be calculated by multiplying the attributable risk by the prevalence of exposure in the population. The attributable proportion is the proportion of the disease that would be eliminated in a population if its disease rate were reduced to that of the unexposed group.

    • This question is part of the following fields:

      • Research Methods, Statistics, Critical Review And Evidence-Based Practice
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  • Question 108 - Which drug is not classified as a controlled substance? ...

    Incorrect

    • Which drug is not classified as a controlled substance?

      Your Answer:

      Correct Answer:

      Explanation:

      Ritalin is a preparation of methylphenidate.

      ADHD (Diagnosis and Management in Children)

      ADHD is a behavioural syndrome characterised by symptoms of inattention, hyperactivity, and impulsivity. The DSM-5 and ICD-11 provide diagnostic criteria for the condition, with both recognising three subtypes: predominantly inattentive, predominantly hyperactive-impulsive, and combined.

      Treatment for children under 5 involves offering an ADHD-focused group parent-training programme as a first-line option. Medication should only be considered after obtaining advice from a specialist ADHD service. For children and young people aged 5-18, advice and support should be given, along with an ADHD-focused group parent-training programme. Medication should only be offered if ADHD symptoms persist after environmental modifications have been implemented and reviewed. Cognitive behavioural therapy may also be considered for those who have benefited from medication but still experience significant impairment.

      NICE advises against elimination diets, dietary fatty acid supplementation, and the use of the ‘few foods diet’. Methylphenidate of lisdexamfetamine is the first-line medication option, with dexamphetamine considered for those who respond to lisdexamfetamine but cannot tolerate the longer effect profile. Atomoxetine of guanfacine may be offered for those who cannot tolerate methylphenidate of lisdexamfetamine. Clonidine and atypical antipsychotics should only be used with advice from a tertiary ADHD service.

      Drug holidays may be considered for children and young people who have not met the expected height for their age due to medication. However, NICE advises that withdrawal from treatment is associated with a risk of symptom exacerbation.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
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  • Question 109 - Which of the following is an atypical characteristic of paranoid personality disorder? ...

    Incorrect

    • Which of the following is an atypical characteristic of paranoid personality disorder?

      Your Answer: Reluctance to confide in others

      Correct Answer: Unusual perceptual disturbances

      Explanation:

      Schizotypal personality disorder is characterized by atypical perceptual experiences.

      Paranoid Personality Disorder is a type of personality disorder where individuals have a deep-seated distrust and suspicion of others, often interpreting their actions as malevolent. This disorder is characterized by a pattern of negative interpretations of others’ words, actions, and intentions, leading to a reluctance to confide in others and holding grudges for long periods of time. The DSM-5 criteria for this disorder include at least four of the following symptoms: unfounded suspicions of exploitation, harm, of deception by others, preoccupation with doubts about the loyalty of trustworthiness of friends of associates, reluctance to confide in others due to fear of malicious use of information, reading negative meanings into benign remarks of events, persistent grudges, perceiving attacks on one’s character of reputation that are not apparent to others and reacting angrily of counterattacking, and recurrent suspicions of infidelity in a partner without justification. The ICD-11 does not have a specific category for paranoid personality disorder but covers many of its features under the negative affectivity qualifier under the element of mistrustfulness.

    • This question is part of the following fields:

      • General Adult Psychiatry
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  • Question 110 - What is the typical age when males begin to experience puberty? ...

    Correct

    • What is the typical age when males begin to experience puberty?

      Your Answer: Age 12

      Explanation:

      Boys typically begin puberty around the age of 12, while girls typically begin around the age of 11.

      Puberty

      Puberty is a natural process that occurs in both boys and girls. The age range for the onset of puberty is between 8-14 years for females and 9-14 years for males, with the mean age of onset being 11 years for girls and 12 years for boys. The duration of puberty is typically 3-4 years. The onset of puberty is marked by the appearance of secondary sex characteristics, such as breast development in females and testicular enlargement in males. These characteristics evolve over time and are rated into 5 stages according to Tanner’s criteria. The sequence of events differs between boys and girls, with the onset of breast development (thelarche) generally preceding the onset of the first period (menarche) by around 2 years in girls. The pubertal growth spurt occurs during stages 3 to 4 in most boys and during stages 2 and 3 in girls. Precocious puberty, which occurs earlier than usual, is more common in girls than in boys. The age of onset of puberty in girls has been decreasing over time, with environmental factors such as nutrition potentially playing a role in this trend.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
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