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  • Question 1 - What is the typical age range of individuals who are diagnosed with Munchausen's...

    Correct

    • What is the typical age range of individuals who are diagnosed with Munchausen's syndrome by proxy?

      Your Answer: 4 years

      Explanation:

      Munchausen’s syndrome by proxy, also known as fabricated or induced illness, is a rare form of child abuse where a caregiver, usually the mother, falsifies illness in a child by fabricating of producing symptoms and presenting the child for medical care while denying knowledge of the cause. It is most commonly seen in children under the age of 4, with symptoms including apnoea, anorexia, feeding problems, and seizures. The disorder is now recognized as ‘Factitious Disorder Imposed on Another’ in the DSM-5, with criteria including falsification of physical of psychological signs of symptoms, presentation of the victim as ill, and evident deceptive behavior. The perpetrator, not the victim, receives this diagnosis. Presenting signs of symptoms can take the form of covert injury, fabrication of symptoms, of exaggeration of existing symptoms. Symptoms are often subjective and easy to fake.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      99.2
      Seconds
  • Question 2 - What is the approximate occurrence rate of schizophrenia among individuals under the age...

    Incorrect

    • What is the approximate occurrence rate of schizophrenia among individuals under the age of 15?

      Your Answer: 1 in 100

      Correct Answer: 1 in 2000

      Explanation:

      Schizophrenia in children is rare compared to adults, with a prevalence estimate of 0.05% for those under 15 years old. There are two classifications based on age of onset: early onset schizophrenia (EOS) when symptoms appear between 13-18 years old, and very early onset schizophrenia (VEOS) when symptoms appear at of before 13 years old. EOS and VEOS have atypical features compared to adult-onset schizophrenia, including insidious onset, more severe neurodevelopmental abnormalities, terrifying visual hallucinations, constant inappropriate of blunted effects, higher rates of familial psychopathology, minor response to treatment, and poorer outcomes. Preliminary data suggests that VEOS and EOS may be due to greater familial vulnerability from genetic, psychosocial, and environmental factors. Poor outcomes are most reliably linked to a positive history of premorbid difficulties, greater symptom severity (especially negative symptoms) at baseline, and longer duration of untreated psychosis. Age at psychosis onset and sex are not consistent predictors of outcome.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      70.1
      Seconds
  • Question 3 - What traits of conditions can be passed down through autosomal dominant inheritance? ...

    Correct

    • What traits of conditions can be passed down through autosomal dominant inheritance?

      Your Answer: Velocardiofacial syndrome

      Explanation:

      Inheritance Patterns and Examples

      Autosomal Dominant:
      Neurofibromatosis type 1 and 2, tuberous sclerosis, achondroplasia, Huntington disease, and Noonan’s syndrome are all examples of conditions that follow an autosomal dominant inheritance pattern. This means that only one copy of the mutated gene is needed to cause the condition.

      Autosomal Recessive:
      Phenylketonuria, homocystinuria, Hurler’s syndrome, galactosaemia, Tay-Sach’s disease, Friedreich’s ataxia, Wilson’s disease, and cystic fibrosis are all examples of conditions that follow an autosomal recessive inheritance pattern. This means that two copies of the mutated gene are needed to cause the condition.

      X-Linked Dominant:
      Vitamin D resistant rickets and Rett syndrome are examples of conditions that follow an X-linked dominant inheritance pattern. This means that the mutated gene is located on the X chromosome and only one copy of the gene is needed to cause the condition.

      X-Linked Recessive:
      Cerebellar ataxia, Hunter’s syndrome, and Lesch-Nyhan are examples of conditions that follow an X-linked recessive inheritance pattern. This means that the mutated gene is located on the X chromosome and two copies of the gene are needed to cause the condition.

      Mitochondrial:
      Leber’s hereditary optic neuropathy and Kearns-Sayre syndrome are examples of conditions that follow a mitochondrial inheritance pattern. This means that the mutated gene is located in the mitochondria and is passed down from the mother to her offspring.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      13.1
      Seconds
  • Question 4 - A 14 year old boy is brought to clinic by his father. He...

    Correct

    • A 14 year old boy is brought to clinic by his father. He is struggling with both obsessive compulsive disorder and depression. Despite trying psychological approaches, he has not found relief and is interested in trying medication. What is the most suitable medication to consider?

      Your Answer: Fluoxetine

      Explanation:

      According to NICE, when a patient has both depression and OCD, the preferred treatment is fluoxetine.

      OCD and BDD are two mental health disorders that can affect children. OCD is characterized by obsessions and compulsions, while BDD is characterized by a preoccupation with an imagined defect in one’s appearance. Both disorders can cause significant distress and impairment in daily functioning.

      For mild cases of OCD, guided self-help may be considered along with support and information for the family of caregivers. For moderate to severe cases of OCD, cognitive-behavioral therapy (CBT) that involves the family of caregivers and is adapted to suit the child’s developmental age is recommended. For all children and young people with BDD, CBT (including exposure and response prevention) is recommended.

      If a child declines psychological treatment, a selective serotonin reuptake inhibitor (SSRI) may be prescribed. However, a licensed medication (sertraline of fluvoxamine) should be used for children and young people with OCD, while fluoxetine should be used for those with BDD. If an SSRI is ineffective of not tolerated, another SSRI of clomipramine may be tried. Tricyclic antidepressants other than clomipramine should not be used to treat OCD of BDD in children and young people. Other antidepressants (MAOIs, SNRIs) and antipsychotics should not be used alone in the routine treatment of OCD of BDD in children of young people, but may be considered as an augmentation strategy.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      1369.2
      Seconds
  • Question 5 - What is the percentage of female individuals who engage in Munchausen's syndrome by...

    Incorrect

    • What is the percentage of female individuals who engage in Munchausen's syndrome by proxy?

      Your Answer: 65%

      Correct Answer: 80%

      Explanation:

      Munchausen’s syndrome by proxy, also known as fabricated or induced illness, is a rare form of child abuse where a caregiver, usually the mother, falsifies illness in a child by fabricating of producing symptoms and presenting the child for medical care while denying knowledge of the cause. It is most commonly seen in children under the age of 4, with symptoms including apnoea, anorexia, feeding problems, and seizures. The disorder is now recognized as ‘Factitious Disorder Imposed on Another’ in the DSM-5, with criteria including falsification of physical of psychological signs of symptoms, presentation of the victim as ill, and evident deceptive behavior. The perpetrator, not the victim, receives this diagnosis. Presenting signs of symptoms can take the form of covert injury, fabrication of symptoms, of exaggeration of existing symptoms. Symptoms are often subjective and easy to fake.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      9.1
      Seconds
  • Question 6 - What is the most accurate estimate of the concordance rate for autism in...

    Correct

    • What is the most accurate estimate of the concordance rate for autism in identical twins?

      Your Answer: 60%

      Explanation:

      Autism Spectrum Disorder (ASD) is a lifelong disorder characterized by deficits in communication and social understanding, as well as restrictive and repetitive behaviors. The distinction between autism and Asperger’s has been abandoned, and they are now grouped together under the ASD category. Intellectual ability is difficult to assess in people with ASD, with an estimated 33% having an intellectual disability. ASD was first described in Europe and the United States using different terms, with Leo Kanner and Hans Asperger being the pioneers. Diagnosis is based on persistent deficits in social communication and social interaction, as well as restricted, repetitive patterns of behavior. The worldwide population prevalence is about 1%, with comorbidity being common. Heritability is estimated at around 90%, and both genetic and environmental factors seem to cause ASD. Currently, there are no validated pharmacological treatments that alleviate core ASD symptoms, but second-generation antipsychotics are the first-line pharmacological treatment for children and adolescents with ASD and associated irritability.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      1943.9
      Seconds
  • Question 7 - If a 14 year old boy with schizophrenia does not show improvement with...

    Correct

    • If a 14 year old boy with schizophrenia does not show improvement with olanzapine or risperidone despite being given adequate doses for adequate durations, what would be your recommendation for the next antipsychotic medication to try?

      Your Answer: Clozapine

      Explanation:

      The NICE guidelines require that before attempting clozapine, at least one second-generation (atypical) antipsychotic should have been tested. There is no mandate for a trial of a typical antipsychotic.

      Antipsychotics in Young People

      Antipsychotics are just as effective in children and adolescents as they are in adults. However, the rate of side effects in young people is higher than in adults. Clozapine is a beneficial second-line agent for treating children with refractory schizophrenia and some argue for its early use in first-episode psychosis. Before starting clozapine, a patient should have tried at least two different antipsychotics, with at least one being a second-generation (atypical) antipsychotic, according to NICE guidelines.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      28.9
      Seconds
  • Question 8 - A 16 year old girl comes to the clinic with her parents. They...

    Correct

    • A 16 year old girl comes to the clinic with her parents. They report a history of strange behaviors and social isolation for the past 18 months. During your examination, you observe hallucinations and delusions. She has a positive family history of schizophrenia. She was previously treated with olanzapine for 6 months, but it did not show any significant improvement. Currently, she is taking risperidone 5 mg twice daily for the past 10 weeks, but there is no noticeable improvement. What would be the appropriate course of action in this case?

      Your Answer: Offer clozapine

      Explanation:

      According to NICE guidance, clozapine should be offered to children and young people with schizophrenia if their illness has not responded adequately to at least two different antipsychotic drugs, each used for 6-8 weeks. The BNF (Children) recommends that risperidone can be used for children aged 12-17 years under expert supervision, with a starting dose of 2mg daily for day 1, followed by 4 mg daily for day 2, and a usual dose of 4-6 mg daily. Doses above 10 mg daily should only be used if the benefit is considered to outweigh the risk, and the maximum daily dose is 16mg. Slower titration may be appropriate for some patients.

      Schizophrenia in children and young people is treated similarly to adults, according to the NICE Guidelines. The Maudsley Guidelines suggest avoiding first generation antipsychotics and using olanzapine, aripiprazole, and risperidone, which have been proven effective in randomized controlled trials. In cases where treatment resistance is present, clozapine should be considered.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      46.6
      Seconds
  • Question 9 - A 7-year-old girl has been referred to your clinic due to concerns raised...

    Correct

    • A 7-year-old girl has been referred to your clinic due to concerns raised by her parents and teachers regarding her inability to focus, impulsivity, and restlessness, which have negatively impacted her academic performance. Which genetic polymorphism is most pertinent to the development of this condition?

      Your Answer: Human dopamine transporter gene (DAT1)

      Explanation:

      The genetic polymorphisms that are associated with the development of hyperkinetic disorder (ADHD) include dopamine transporter (DAT1) and dopamine receptor related (DRD4). On the other hand, DBP, DISC1, and NRG are polymorphisms that are relevant to schizophrenia, while APP is associated with Alzheimer’s disease. Additionally, the DISC1 gene is believed to increase the likelihood of developing bipolar disorder and major depressive disorder.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      22.6
      Seconds
  • Question 10 - What is a common characteristic observed in a patient diagnosed with DiGeorge syndrome?...

    Correct

    • What is a common characteristic observed in a patient diagnosed with DiGeorge syndrome?

      Your Answer: Cleft palate

      Explanation:

      The condition associated with flapping hand movements is either Angelman syndrome of Fragile X, while hyperphagia is a symptom of Prader-Willi syndrome. Overlapping of fingers over thumb is seen in Patau syndrome, and pronounced self-injurious behavior is a feature of Lesch-Nyhan syndrome of Smith-Magenis syndrome. DiGeorge syndrome is typically caused by a deletion on chromosome 22 and presents with a variety of symptoms, including cardiac abnormalities (tetralogy of Fallot), abnormal facies (almond-shaped eyes, low-set ears), thymic aplasia (leading to recurrent infections), cleft palate, and hypocalcemia/hypoparathyroidism (resulting in short stature and seizures). Learning disabilities are also common in individuals with DiGeorge syndrome, and they may also be at increased risk for psychiatric conditions such as depression, ADHD, and schizophrenia.

      Genetic Conditions and Their Features

      Genetic conditions are disorders caused by abnormalities in an individual’s DNA. These conditions can affect various aspects of a person’s health, including physical and intellectual development. Some of the most common genetic conditions and their features are:

      – Downs (trisomy 21): Short stature, almond-shaped eyes, low muscle tone, and intellectual disability.
      – Angelman syndrome (Happy puppet syndrome): Flapping hand movements, ataxia, severe learning disability, seizures, and sleep problems.
      – Prader-Willi: Hyperphagia, excessive weight gain, short stature, and mild learning disability.
      – Cri du chat: Characteristic cry, hypotonia, down-turned mouth, and microcephaly.
      – Velocardiofacial syndrome (DiGeorge syndrome): Cleft palate, cardiac problems, and learning disabilities.
      – Edwards syndrome (trisomy 18): Severe intellectual disability, kidney malformations, and physical abnormalities.
      – Lesch-Nyhan syndrome: Self-mutilation, dystonia, and writhing movements.
      – Smith-Magenis syndrome: Pronounced self-injurious behavior, self-hugging, and a hoarse voice.
      – Fragile X: Elongated face, large ears, hand flapping, and shyness.
      – Wolf Hirschhorn syndrome: Mild to severe intellectual disability, seizures, and physical abnormalities.
      – Patau syndrome (trisomy 13): Severe intellectual disability, congenital heart malformations, and physical abnormalities.
      – Rett syndrome: Regression and loss of skills, hand-wringing movements, and profound learning disability.
      – Tuberous sclerosis: Hamartomatous tumors, epilepsy, and behavioral issues.
      – Williams syndrome: Elfin-like features, social disinhibition, and advanced verbal skills.
      – Rubinstein-Taybi syndrome: Short stature, friendly disposition, and moderate learning disability.
      – Klinefelter syndrome: Extra X chromosome, low testosterone, and speech and language issues.
      – Jakob’s syndrome: Extra Y chromosome, tall stature, and lower mean intelligence.
      – Coffin-Lowry syndrome: Short stature, slanting eyes, and severe learning difficulty.
      – Turner syndrome: Short stature, webbed neck, and absent periods.
      – Niemann Pick disease (types A and B): Abdominal swelling, cherry red spot, and feeding difficulties.

      It is important to note that these features may vary widely among individuals with the same genetic condition. Early diagnosis and intervention can help individuals with genetic conditions reach their full potential and improve their quality of life.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      5.8
      Seconds
  • Question 11 - What is the estimated percentage of children with conduct disorders who are believed...

    Correct

    • What is the estimated percentage of children with conduct disorders who are believed to fulfill the diagnostic criteria for antisocial personality disorder in adulthood?

      Your Answer: 50%

      Explanation:

      Disruptive Behaviour of Dissocial Disorders

      Conduct disorders are the most common reason for referral of young children to mental health services. These disorders are characterized by a repetitive and persistent pattern of antisocial, aggressive, of defiant conduct that goes beyond ordinary childish mischief of adolescent rebelliousness. Oppositional defiant disorder (ODD) shares some negative attributes but in a more limited fashion.

      ICD-11 terms the disorder as ‘Conduct-dissocial disorder’, while DSM-5 recognizes three separate conditions related to emotional/behavioral problems seen in younger people: conduct disorder, oppositional defiant disorder, and intermittent explosive disorder. Conduct disorder is about poorly controlled behavior, intermittent explosive disorder is about poorly controlled emotions, and ODD is in between. Conduct disorders are further divided into childhood onset (before 10 years) and adolescent onset (10 years of older).

      The behavior pattern of conduct disorders must be persistent and recurrent, including multiple incidents of aggression towards people of animals, destruction of property, deceitfulness of theft, and serious violations of rules. The pattern of behavior must result in significant impairment in personal, family, social, educational, occupational, of other important areas of functioning.

      Oppositional defiant disorder represents a less severe form of conduct disorder, where there is an absence of more severe dissocial of aggressive acts. The behavior pattern of ODD includes persistent difficulty getting along with others, provocative, spiteful, of vindictive behavior, and extreme irritability of anger.

      The prevalence of conduct disorders increases throughout childhood and is more common in boys than girls. The most frequent comorbid problem seen with conduct disorder is hyperactivity. The conversion rate from childhood conduct disorder to adult antisocial personality disorder varies from 40 to 70% depending on the study.

      NICE recommends group parent-based training programs of parent and child training programs for children with complex needs for ages 3-11, child-focused programs for ages 9-14, and multimodal interventions with a family focus for ages 11-17. Medication is not recommended in routine practice, but risperidone can be used where other approaches fail and they are seriously aggressive.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      52
      Seconds
  • Question 12 - At any given time, what is the percentage of 10 year olds who...

    Incorrect

    • At any given time, what is the percentage of 10 year olds who suffer from nocturnal enuresis?

      Your Answer: 25%

      Correct Answer: 5%

      Explanation:

      Elimination Disorders

      Elimination disorders refer to conditions that affect a child’s ability to control their bladder of bowel movements. Enuresis, of lack of control over the bladder, typically occurs between the ages of 1-3, while control over the bowel usually occurs before that of the bladder for most toddlers. Toilet training can be influenced by various factors, including intellectual capacity, cultural determinants, and psychological interactions between the child and their parents.

      Enuresis is characterized by involuntary voiding of urine, by day and/of by night, which is abnormal in relation to the individual’s age and is not a result of any physical abnormality. It is not normally diagnosed before age 5 and may be primary (the child never having achieved continence) of secondary. Treatment options include reassurance, enuresis alarms, and medication.

      Encopresis refers to repeated stool evacuation in inappropriate places in children over the age of four. The behavior can be either involuntary of intentional and may be due to unsuccessful toilet training (primary encopresis) of occur after a period of normal bowel control (secondary encopresis). Treatment generally involves bowel clearance, prevention of impaction, and behavioral therapy.

      Before a diagnosis of encopresis is made, organic causes must be excluded. Hirschsprung’s disease is a condition that results from an absence of parasympathetic ganglion cells in the rectum, colon, and sometimes the small intestine. It leads to a colonic obstruction and is diagnosed in at least half of all cases in the first year of life. It is twice as common in boys than in girls.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      29.2
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  • Question 13 - A 7-year-old girl is brought to your clinic by her parents who are...

    Correct

    • A 7-year-old girl is brought to your clinic by her parents who are worried about her excessive need for order and cleanliness. Upon examination, you observe signs of obsessive rumination and compulsions. The girl has a history of streptococcal sore throat, leading you to suspect that it may have played a role in the development of her condition. Which of the following serum titres would be most likely to be elevated if this is the case?

      Your Answer: Anti-DNAse

      Explanation:

      Elevated ASLO of antistreptolysin O titres, which are anti-DNAse, are often present in cases of paediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS), a syndrome that may be linked to the development of childhood obsessive-compulsive disorder (OCD).

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      26.4
      Seconds
  • Question 14 - A 25-year-old woman presents to your clinic with concerns about her body image...

    Correct

    • A 25-year-old woman presents to your clinic with concerns about her body image and eating habits. Despite having a healthy BMI of 20 kg/m2, she feels overweight and restricts her food intake at times while bingeing at other times. She has not experienced amenorrhea. You decide to utilize the Eating Attitudes Test to assist in your diagnosis.
      What is the rating system for this assessment tool?

      Your Answer: Self rated

      Explanation:

      The EAT, of Eating Attitudes Test, is a commonly used screening tool for diagnosing eating disorders. It is a self-rated test that evaluates attitudes towards food and eating. The test has been extensively studied and has been found to have good psychometric properties. For more information, see Garner et al.’s 1982 article in Psychol Med of visit the EAT-26 website.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      22.4
      Seconds
  • Question 15 - What is the most frequently observed behavior in children diagnosed with conduct disorder?...

    Correct

    • What is the most frequently observed behavior in children diagnosed with conduct disorder?

      Your Answer: Hyperactivity

      Explanation:

      Disruptive Behaviour of Dissocial Disorders

      Conduct disorders are the most common reason for referral of young children to mental health services. These disorders are characterized by a repetitive and persistent pattern of antisocial, aggressive, of defiant conduct that goes beyond ordinary childish mischief of adolescent rebelliousness. Oppositional defiant disorder (ODD) shares some negative attributes but in a more limited fashion.

      ICD-11 terms the disorder as ‘Conduct-dissocial disorder’, while DSM-5 recognizes three separate conditions related to emotional/behavioral problems seen in younger people: conduct disorder, oppositional defiant disorder, and intermittent explosive disorder. Conduct disorder is about poorly controlled behavior, intermittent explosive disorder is about poorly controlled emotions, and ODD is in between. Conduct disorders are further divided into childhood onset (before 10 years) and adolescent onset (10 years of older).

      The behavior pattern of conduct disorders must be persistent and recurrent, including multiple incidents of aggression towards people of animals, destruction of property, deceitfulness of theft, and serious violations of rules. The pattern of behavior must result in significant impairment in personal, family, social, educational, occupational, of other important areas of functioning.

      Oppositional defiant disorder represents a less severe form of conduct disorder, where there is an absence of more severe dissocial of aggressive acts. The behavior pattern of ODD includes persistent difficulty getting along with others, provocative, spiteful, of vindictive behavior, and extreme irritability of anger.

      The prevalence of conduct disorders increases throughout childhood and is more common in boys than girls. The most frequent comorbid problem seen with conduct disorder is hyperactivity. The conversion rate from childhood conduct disorder to adult antisocial personality disorder varies from 40 to 70% depending on the study.

      NICE recommends group parent-based training programs of parent and child training programs for children with complex needs for ages 3-11, child-focused programs for ages 9-14, and multimodal interventions with a family focus for ages 11-17. Medication is not recommended in routine practice, but risperidone can be used where other approaches fail and they are seriously aggressive.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      49.6
      Seconds
  • Question 16 - A 16-year-old girl is referred to you after being caught stealing a phone...

    Incorrect

    • A 16-year-old girl is referred to you after being caught stealing a phone from a store and attempting to leave without paying. Her parents are worried as they have heard rumors of her skipping school with friends and using inhalants. She has been displaying more aggressive behavior lately, such as throwing objects at her mother when asked to do chores. What is the most probable diagnosis?

      Your Answer: Oppositional defiant disorder

      Correct Answer: Conduct disorder

      Explanation:

      Conduct disorders are defined by a consistent and recurring pattern of behavior that is defiant, aggressive, of dissocial. This behavior should be severe enough to violate social expectations that are appropriate for the individual’s age, and should not be mistaken for typical adolescent rebellion of childish mischief. The diagnosis is not based on isolated criminal of dissocial acts, but rather on a persistent pattern of behavior.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      26.1
      Seconds
  • Question 17 - What is the condition that occurs as a result of the deletion of...

    Correct

    • What is the condition that occurs as a result of the deletion of the maternal chromosome 15q?

      Your Answer: Angelman syndrome

      Explanation:

      Genetic Conditions and Their Features

      Genetic conditions are disorders caused by abnormalities in an individual’s DNA. These conditions can affect various aspects of a person’s health, including physical and intellectual development. Some of the most common genetic conditions and their features are:

      – Downs (trisomy 21): Short stature, almond-shaped eyes, low muscle tone, and intellectual disability.
      – Angelman syndrome (Happy puppet syndrome): Flapping hand movements, ataxia, severe learning disability, seizures, and sleep problems.
      – Prader-Willi: Hyperphagia, excessive weight gain, short stature, and mild learning disability.
      – Cri du chat: Characteristic cry, hypotonia, down-turned mouth, and microcephaly.
      – Velocardiofacial syndrome (DiGeorge syndrome): Cleft palate, cardiac problems, and learning disabilities.
      – Edwards syndrome (trisomy 18): Severe intellectual disability, kidney malformations, and physical abnormalities.
      – Lesch-Nyhan syndrome: Self-mutilation, dystonia, and writhing movements.
      – Smith-Magenis syndrome: Pronounced self-injurious behavior, self-hugging, and a hoarse voice.
      – Fragile X: Elongated face, large ears, hand flapping, and shyness.
      – Wolf Hirschhorn syndrome: Mild to severe intellectual disability, seizures, and physical abnormalities.
      – Patau syndrome (trisomy 13): Severe intellectual disability, congenital heart malformations, and physical abnormalities.
      – Rett syndrome: Regression and loss of skills, hand-wringing movements, and profound learning disability.
      – Tuberous sclerosis: Hamartomatous tumors, epilepsy, and behavioral issues.
      – Williams syndrome: Elfin-like features, social disinhibition, and advanced verbal skills.
      – Rubinstein-Taybi syndrome: Short stature, friendly disposition, and moderate learning disability.
      – Klinefelter syndrome: Extra X chromosome, low testosterone, and speech and language issues.
      – Jakob’s syndrome: Extra Y chromosome, tall stature, and lower mean intelligence.
      – Coffin-Lowry syndrome: Short stature, slanting eyes, and severe learning difficulty.
      – Turner syndrome: Short stature, webbed neck, and absent periods.
      – Niemann Pick disease (types A and B): Abdominal swelling, cherry red spot, and feeding difficulties.

      It is important to note that these features may vary widely among individuals with the same genetic condition. Early diagnosis and intervention can help individuals with genetic conditions reach their full potential and improve their quality of life.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      8.4
      Seconds
  • Question 18 - A 14-year-old girl is referred by her GP due to concerning behaviour. She...

    Correct

    • A 14-year-old girl is referred by her GP due to concerning behaviour. She has been involved in physical altercations with several of her classmates and is consistently disobedient towards her mother. In the past year, she has committed multiple offenses and has been convicted several times. What would be the most suitable course of action?

      Your Answer: Multimodal interventions with a family focus

      Explanation:

      Based on his behavior, it appears that he may have conduct disorder. As for the girl, parent training programs may not be suitable for her given her age. Instead, a more comprehensive approach is needed that addresses individual, family, school, criminal justice, and community factors. This approach, referred to as multimodal interventions with a family focus by NICE, would be more appropriate.

      Disruptive Behaviour of Dissocial Disorders

      Conduct disorders are the most common reason for referral of young children to mental health services. These disorders are characterized by a repetitive and persistent pattern of antisocial, aggressive, of defiant conduct that goes beyond ordinary childish mischief of adolescent rebelliousness. Oppositional defiant disorder (ODD) shares some negative attributes but in a more limited fashion.

      ICD-11 terms the disorder as ‘Conduct-dissocial disorder’, while DSM-5 recognizes three separate conditions related to emotional/behavioral problems seen in younger people: conduct disorder, oppositional defiant disorder, and intermittent explosive disorder. Conduct disorder is about poorly controlled behavior, intermittent explosive disorder is about poorly controlled emotions, and ODD is in between. Conduct disorders are further divided into childhood onset (before 10 years) and adolescent onset (10 years of older).

      The behavior pattern of conduct disorders must be persistent and recurrent, including multiple incidents of aggression towards people of animals, destruction of property, deceitfulness of theft, and serious violations of rules. The pattern of behavior must result in significant impairment in personal, family, social, educational, occupational, of other important areas of functioning.

      Oppositional defiant disorder represents a less severe form of conduct disorder, where there is an absence of more severe dissocial of aggressive acts. The behavior pattern of ODD includes persistent difficulty getting along with others, provocative, spiteful, of vindictive behavior, and extreme irritability of anger.

      The prevalence of conduct disorders increases throughout childhood and is more common in boys than girls. The most frequent comorbid problem seen with conduct disorder is hyperactivity. The conversion rate from childhood conduct disorder to adult antisocial personality disorder varies from 40 to 70% depending on the study.

      NICE recommends group parent-based training programs of parent and child training programs for children with complex needs for ages 3-11, child-focused programs for ages 9-14, and multimodal interventions with a family focus for ages 11-17. Medication is not recommended in routine practice, but risperidone can be used where other approaches fail and they are seriously aggressive.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
      6937.9
      Seconds
  • Question 19 - What is the primary treatment recommended by NICE for managing conduct disorder? ...

    Correct

    • What is the primary treatment recommended by NICE for managing conduct disorder?

      Your Answer: Group based parent training

      Explanation:

      Disruptive Behaviour of Dissocial Disorders

      Conduct disorders are the most common reason for referral of young children to mental health services. These disorders are characterized by a repetitive and persistent pattern of antisocial, aggressive, of defiant conduct that goes beyond ordinary childish mischief of adolescent rebelliousness. Oppositional defiant disorder (ODD) shares some negative attributes but in a more limited fashion.

      ICD-11 terms the disorder as ‘Conduct-dissocial disorder’, while DSM-5 recognizes three separate conditions related to emotional/behavioral problems seen in younger people: conduct disorder, oppositional defiant disorder, and intermittent explosive disorder. Conduct disorder is about poorly controlled behavior, intermittent explosive disorder is about poorly controlled emotions, and ODD is in between. Conduct disorders are further divided into childhood onset (before 10 years) and adolescent onset (10 years of older).

      The behavior pattern of conduct disorders must be persistent and recurrent, including multiple incidents of aggression towards people of animals, destruction of property, deceitfulness of theft, and serious violations of rules. The pattern of behavior must result in significant impairment in personal, family, social, educational, occupational, of other important areas of functioning.

      Oppositional defiant disorder represents a less severe form of conduct disorder, where there is an absence of more severe dissocial of aggressive acts. The behavior pattern of ODD includes persistent difficulty getting along with others, provocative, spiteful, of vindictive behavior, and extreme irritability of anger.

      The prevalence of conduct disorders increases throughout childhood and is more common in boys than girls. The most frequent comorbid problem seen with conduct disorder is hyperactivity. The conversion rate from childhood conduct disorder to adult antisocial personality disorder varies from 40 to 70% depending on the study.

      NICE recommends group parent-based training programs of parent and child training programs for children with complex needs for ages 3-11, child-focused programs for ages 9-14, and multimodal interventions with a family focus for ages 11-17. Medication is not recommended in routine practice, but risperidone can be used where other approaches fail and they are seriously aggressive.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
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  • Question 20 - What is a true statement about childhood disintegrative disorder? ...

    Incorrect

    • What is a true statement about childhood disintegrative disorder?

      Your Answer: The onset is generally between the ages of 4-8

      Correct Answer: Normal development is expected for at least 24 months prior to regression

      Explanation:

      Childhood disintegrative disorder, also known as Heller’s syndrome, is identified by significant regression in multiple areas of development after at least two years of typical development. While it was previously considered a distinct disorder, it is now classified as a subset of autism in DSM-V. The estimated prevalence of this disorder is 1 in 100,000, with a higher incidence in boys than girls at a ratio of 4-8:1. Typically, symptoms begin to manifest between the ages of 3-4 years.

      Rett Syndrome: A Rare Neurodevelopmental Disorder

      Rett syndrome is a neurodevelopmental disorder that is rare, affecting approximately 1 in 10,000 female births. Although it mostly affects females, there have been cases of males with the disorder. While the exact cause of the disorder is not known, it is believed to have a genetic basis, with mutations in the MECP2 gene (Xq28) being associated with the disorder. Monozygotic twins have been found to have complete concordance in cases of Rett syndrome.

      The disorder has a unique presentation, with affected children experiencing a normal period of development until 6-18 months. After this period, they begin to develop problems with language, losing previously acquired speech. Purposeful hand movements are replaced with stereotypic movements, such as hand wringing, and ataxia and psychomotor retardation may occur. Other stereotypical movements, such as finger licking of biting and tapping of slapping, may also be seen. Head circumference is normal at birth, but growth begins to decelerate between 6-12 months, resulting in microcephaly. All language skills are lost, both receptive and expressive, and social skills plateau at developmental levels between 6-12 months.

      Seizures are associated with Rett syndrome in 75% of those affected, and almost all affected children have abnormal EEG findings. Breathing problems, such as hyperventilation, apnea, and breath holding, are also seen. Children with Rett syndrome may live for well over a decade after the onset of the disorder, but after 10 years, many patients are wheelchair-bound with virtually no language ability. Additional features of the disorder include seizures, breath holding and hyperventilation, sleep difficulties, and issues with locomotion.

    • This question is part of the following fields:

      • Child And Adolescent Psychiatry
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