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  • Question 1 - A 28-year-old pregnant female arrives at the Emergency Department complaining of pleuritic chest...

    Incorrect

    • A 28-year-old pregnant female arrives at the Emergency Department complaining of pleuritic chest pain and dyspnea that came on suddenly. She recently returned from a trip to New Zealand. Based on the choices, what is the most probable finding on her ECG, if any?

      Your Answer: ST elevation in leads II, III and aVF

      Correct Answer: T wave inversion in the anterior leads

      Explanation:

      Patients with pulmonary embolism may exhibit sinus tachycardia as the most common ECG sign, as well as signs of right heart strain rather than left.

      Pulmonary embolism can be difficult to diagnose as it can present with a variety of cardiorespiratory symptoms and signs depending on its location and size. The PIOPED study in 2007 found that tachypnea, crackles, tachycardia, and fever were common clinical signs in patients diagnosed with pulmonary embolism. The Well’s criteria for diagnosing a PE use tachycardia rather than tachypnea. All patients with symptoms or signs suggestive of a PE should have a history taken, examination performed, and a chest x-ray to exclude other pathology.

      To rule out a PE, the pulmonary embolism rule-out criteria (PERC) can be used. All criteria must be absent to have a negative PERC result, which reduces the probability of PE to less than 2%. If the suspicion of PE is greater than this, a 2-level PE Wells score should be performed. A score of more than 4 points indicates a likely PE, and an immediate computed tomography pulmonary angiogram (CTPA) should be arranged. If the CTPA is negative, patients do not need further investigations or treatment for PE.

      CTPA is now the recommended initial lung-imaging modality for non-massive PE. V/Q scanning may be used initially if appropriate facilities exist, the chest x-ray is normal, and there is no significant symptomatic concurrent cardiopulmonary disease. D-dimer levels should be considered for patients over 50 years old. A chest x-ray is recommended for all patients to exclude other pathology, but it is typically normal in PE. The sensitivity of V/Q scanning is around 75%, while the specificity is 97%. Peripheral emboli affecting subsegmental arteries may be missed on CTPA.

    • This question is part of the following fields:

      • Cardiovascular System
      15.5
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  • Question 2 - A 25-year-old man comes to the clinic complaining of chest pain in the...

    Incorrect

    • A 25-year-old man comes to the clinic complaining of chest pain in the center of his chest. Based on his symptoms, pericarditis is suspected as the cause. The patient is typically healthy, but recently had a viral throat infection according to his primary care physician.

      What is the most probable observation in this patient?

      Your Answer: A heart rate of less than 50 beats per minute

      Correct Answer: Chest pain which is relieved on leaning forwards

      Explanation:

      Pericarditis is inflammation of the pericardium, a sac surrounding the heart. It can be caused by various factors, including viral infections. The typical symptom of pericarditis is central chest pain that is relieved by sitting up or leaning forward. ST-segment depression on a 12-lead ECG is not a sign of pericarditis, but rather a sign of subendocardial tissue ischemia. A pansystolic cardiac murmur heard on auscultation is also not associated with pericarditis, as it is caused by valve defects. Additionally, pericarditis is not typically associated with bradycardia, but rather tachycardia.

      Acute Pericarditis: Causes, Features, Investigations, and Management

      Acute pericarditis is a possible diagnosis for patients presenting with chest pain. The condition is characterized by chest pain, which may be pleuritic and relieved by sitting forwards. Other symptoms include non-productive cough, dyspnoea, and flu-like symptoms. Tachypnoea and tachycardia may also be present, along with a pericardial rub.

      The causes of acute pericarditis include viral infections, tuberculosis, uraemia, trauma, post-myocardial infarction, Dressler’s syndrome, connective tissue disease, hypothyroidism, and malignancy.

      Investigations for acute pericarditis include ECG changes, which are often global/widespread, as opposed to the ‘territories’ seen in ischaemic events. The ECG may show ‘saddle-shaped’ ST elevation and PR depression, which is the most specific ECG marker for pericarditis. All patients with suspected acute pericarditis should have transthoracic echocardiography.

      Management of acute pericarditis involves treating the underlying cause. A combination of NSAIDs and colchicine is now generally used as first-line treatment for patients with acute idiopathic or viral pericarditis.

      In summary, acute pericarditis is a possible diagnosis for patients presenting with chest pain. The condition is characterized by chest pain, which may be pleuritic and relieved by sitting forwards, along with other symptoms. The causes of acute pericarditis are varied, and investigations include ECG changes and transthoracic echocardiography. Management involves treating the underlying cause and using a combination of NSAIDs and colchicine as first-line treatment.

    • This question is part of the following fields:

      • Cardiovascular System
      22.5
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  • Question 3 - A 7-year-old girl with Down Syndrome presents to her General Practitioner (GP) with...

    Incorrect

    • A 7-year-old girl with Down Syndrome presents to her General Practitioner (GP) with complaints of getting tired easily while playing with her friends and experiencing shortness of breath. The mother informs the GP that the patient was born with an uncorrected cardiac defect. On examination, the GP observes clubbing and plethora.

      What is the probable reason for the patient's current symptoms?

      Your Answer: Transposition of the great vessels

      Correct Answer: Eisenmenger syndrome

      Explanation:

      The presence of clubbing, cyanosis, and easy fatigue in this patient suggests Eisenmenger syndrome, which can occur as a result of an uncorrected VSD commonly seen in individuals with Down syndrome. The increased pulmonary blood flow caused by the VSD can lead to pulmonary hypertension and vascular remodeling, resulting in RV hypertrophy and a reversal of the shunt. In contrast, coarctation of the aorta typically presents with hypertension and pulse discrepancies, but not clubbing or plethora. Ebstein abnormality, caused by prenatal exposure to lithium, can cause fatigue and early tiring, but does not typically result in clubbing. Transposition of the great vessels would likely have been fatal without correction, making it an unlikely diagnosis in this case.

      Understanding Eisenmenger’s Syndrome

      Eisenmenger’s syndrome is a medical condition that occurs when a congenital heart defect leads to pulmonary hypertension, causing a reversal of a left-to-right shunt. This happens when the left-to-right shunt is not corrected, leading to the remodeling of the pulmonary microvasculature, which eventually obstructs pulmonary blood and causes pulmonary hypertension. The condition is commonly associated with ventricular septal defect, atrial septal defect, and patent ductus arteriosus.

      The original murmur may disappear, and patients may experience cyanosis, clubbing, right ventricular failure, haemoptysis, and embolism. Management of Eisenmenger’s syndrome requires heart-lung transplantation. It is essential to diagnose and treat the condition early to prevent complications and improve the patient’s quality of life. Understanding the causes, symptoms, and management of Eisenmenger’s syndrome is crucial for healthcare professionals to provide appropriate care and support to patients with this condition.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 4 - A patient develops a broad complex tachycardia three days following a myocardial infarction....

    Incorrect

    • A patient develops a broad complex tachycardia three days following a myocardial infarction. What is the primary mechanism of action of intravenous amiodarone in this case?

      Your Answer: Shortens QT interval

      Correct Answer: Blocks voltage-gated potassium channels

      Explanation:

      Amiodarone’s mechanism of action involves the inhibition of potassium channels.

      Amiodarone is a medication used to treat various types of abnormal heart rhythms. It works by blocking potassium channels, which prolongs the action potential and helps to regulate the heartbeat. However, it also has other effects, such as blocking sodium channels. Amiodarone has a very long half-life, which means that loading doses are often necessary. It should ideally be given into central veins to avoid thrombophlebitis. Amiodarone can cause proarrhythmic effects due to lengthening of the QT interval and can interact with other drugs commonly used at the same time. Long-term use of amiodarone can lead to various adverse effects, including thyroid dysfunction, corneal deposits, pulmonary fibrosis/pneumonitis, liver fibrosis/hepatitis, peripheral neuropathy, myopathy, photosensitivity, a ‘slate-grey’ appearance, thrombophlebitis, injection site reactions, and bradycardia. Patients taking amiodarone should be monitored regularly with tests such as TFT, LFT, U&E, and CXR.

    • This question is part of the following fields:

      • Cardiovascular System
      37
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  • Question 5 - A 65-year-old male comes to the GP complaining of mild chest pain and...

    Incorrect

    • A 65-year-old male comes to the GP complaining of mild chest pain and dyspnoea. The patient has no significant medical history but has a family history of heart disease, with his father passing away following a heart attack last year. The GP suspects atrial flutter and decides to perform an ECG to confirm the diagnosis. What ECG findings would you anticipate given the diagnosis?

      Your Answer: Heart rate of 58/min

      Correct Answer: Narrow complex tachycardia

      Explanation:

      Atrial flutter is characterized by a sawtooth pattern on ECG and typically presents as a narrow complex tachycardia. The regular atrial activity in atrial flutter is typically 300 bpm, and the ventricular rate is a fraction of this. For example, a 2:1 block would result in a ventricular rate of 150/min, a 3:1 block would result in a ventricular rate of 100/min, and a 4:1 block would result in a ventricular rate of 75/min.

      Atrial flutter is a type of supraventricular tachycardia that is characterized by a series of rapid atrial depolarization waves. This condition can be identified through ECG findings, which show a sawtooth appearance. The underlying atrial rate is typically around 300 beats per minute, which can affect the ventricular or heart rate depending on the degree of AV block. For instance, if there is a 2:1 block, the ventricular rate will be 150 beats per minute. Flutter waves may also be visible following carotid sinus massage or adenosine.

      Managing atrial flutter is similar to managing atrial fibrillation, although medication may be less effective. However, atrial flutter is more sensitive to cardioversion, so lower energy levels may be used. For most patients, radiofrequency ablation of the tricuspid valve isthmus is curative.

    • This question is part of the following fields:

      • Cardiovascular System
      56.9
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  • Question 6 - Which one of the following is not considered a major branch of the...

    Correct

    • Which one of the following is not considered a major branch of the ascending thoracic aorta?

      Your Answer: Inferior thyroid artery

      Explanation:

      The thyrocervical trunk, which is a branch of the subclavian artery, is typically the source of the inferior thyroid artery.

      Anatomy of the Thoracic Aorta

      The thoracic aorta is a major blood vessel that originates from the fourth thoracic vertebrae and terminates at the twelfth thoracic vertebrae. It is located in the chest cavity and has several important relations with surrounding structures. Anteriorly, it is related to the root of the left lung, the pericardium, the oesophagus, and the diaphragm. Posteriorly, it is related to the vertebral column and the azygos vein. On the right side, it is related to the hemiazygos veins and the thoracic duct, while on the left side, it is related to the left pleura and lung.

      The thoracic aorta has several branches that supply blood to different parts of the body. The lateral segmental branches are the posterior intercostal arteries, which supply blood to the muscles and skin of the back. The lateral visceral branches are the bronchial arteries, which supply blood to the bronchial walls and lung, excluding the alveoli. The midline branches are the oesophageal arteries, which supply blood to the oesophagus.

      In summary, the thoracic aorta is an important blood vessel that supplies blood to various structures in the chest cavity. Its anatomy and relations with surrounding structures are crucial for understanding its function and potential clinical implications.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 7 - A 70-year-old female is brought to the Emergency department with a severe crushing...

    Incorrect

    • A 70-year-old female is brought to the Emergency department with a severe crushing chest pain that was alleviated by sublingual GTN. The medical team diagnoses her with acute coronary syndrome (ACS). What test can distinguish between unstable angina and non-ST elevation MI (NSTEMI), both of which are types of ACS?

      Your Answer: Chest radiograph

      Correct Answer: Troponin level

      Explanation:

      Acute Coronary Syndrome

      Acute coronary syndrome is a term used to describe a range of conditions that affect the heart, including unstable angina, non-ST elevation MI (NSTEMI), and ST elevation MI (STEMI). The detection of raised cardiac enzymes is the definitive test in distinguishing between NSTEMI and unstable angina. If the enzymes are raised, it indicates myocardial tissue infarction, which is present in NSTEMI but not in unstable angina. Clinical history and exercise ECG testing are also important in distinguishing between these conditions. It is important to understand the differences between these conditions in order to provide appropriate treatment and management.

    • This question is part of the following fields:

      • Cardiovascular System
      38.4
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  • Question 8 - Mrs. Green is a 64-year-old woman with colon cancer. She is undergoing adjuvant...

    Incorrect

    • Mrs. Green is a 64-year-old woman with colon cancer. She is undergoing adjuvant chemotherapy, however in the past six months has suffered four deep vein thrombosis (DVT) events, despite being optimally anticoagulated with the maximum dose of dabigatran. On one occasion she suffered a DVT during treatment with dalteparin (a low molecular weight heparin). She has been admitted with symptoms of another DVT.

      What is the recommended treatment for her current DVT?

      Your Answer:

      Correct Answer: Insert an inferior vena caval filter

      Explanation:

      For patients with recurrent venous thromboembolic disease, an inferior vena cava filter may be considered. This is particularly relevant for patients with cancer who have experienced multiple DVTs despite being fully anticoagulated. Before considering an inferior vena cava filter, alternative treatments such as increasing the target INR to 3-4 for long-term high-intensity oral anticoagulant therapy or switching to LMWH should be considered. This recommendation is in line with NICE guidelines on the diagnosis, management, and thrombophilia testing of venous thromboembolic diseases. Prescribing apixaban, increasing the dose of dabigatran off-license, or prescribing Thrombo-Embolic Deterrent (TED) stockings are not appropriate solutions for this patient. Similarly, initiating end-of-life drugs and preparing the family is not indicated based on the clinical description provided.

      Management of Pulmonary Embolism

      Pulmonary embolism (PE) is a serious condition that requires prompt management. The National Institute for Health and Care Excellence (NICE) updated their guidelines on the management of venous thromboembolism (VTE) in 2020, with some key changes. One of the significant changes is the recommendation to use direct oral anticoagulants (DOACs) as the first-line treatment for most people with VTE, including those with active cancer. Another change is the increasing use of outpatient treatment for low-risk PE patients, determined by a validated risk stratification tool.

      Anticoagulant therapy is the cornerstone of VTE management. The guidelines recommend using apixaban or rivaroxaban as the first-line treatment for PE, followed by LMWH, dabigatran, edoxaban, or a vitamin K antagonist (VKA) if necessary. For patients with active cancer, DOACs are now recommended instead of LMWH. The length of anticoagulation depends on whether the VTE was provoked or unprovoked, with treatment typically lasting for at least three months. Patients with unprovoked VTE may continue treatment for up to six months, depending on their risk of recurrence and bleeding.

      In cases of haemodynamic instability, thrombolysis is recommended as the first-line treatment for massive PE with circulatory failure. Other invasive approaches may also be considered where appropriate facilities exist. Patients who have repeat pulmonary embolisms, despite adequate anticoagulation, may be considered for inferior vena cava (IVC) filters. However, the evidence base for IVC filter use is weak, and further studies are needed.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 9 - A 25-year-old man has a cannula inserted into his cephalic vein. What is...

    Incorrect

    • A 25-year-old man has a cannula inserted into his cephalic vein. What is the structure through which the cephalic vein passes?

      Your Answer:

      Correct Answer: Clavipectoral fascia

      Explanation:

      Preserving the cephalic vein is important for creating an arteriovenous fistula in patients with end stage renal failure, as it is a preferred vessel for this purpose. The vein travels through the calvipectoral fascia, but does not pass through the pectoralis major muscle, before ending in the axillary vein.

      The Cephalic Vein: Path and Connections

      The cephalic vein is a major blood vessel that runs along the lateral side of the arm. It begins at the dorsal venous arch, which drains blood from the hand and wrist, and travels up the arm, crossing the anatomical snuffbox. At the antecubital fossa, the cephalic vein is connected to the basilic vein by the median cubital vein. This connection is commonly used for blood draws and IV insertions.

      After passing through the antecubital fossa, the cephalic vein continues up the arm and pierces the deep fascia of the deltopectoral groove to join the axillary vein. This junction is located near the shoulder and marks the end of the cephalic vein’s path.

      Overall, the cephalic vein plays an important role in the circulation of blood in the upper limb. Its connections to other major veins in the arm make it a valuable site for medical procedures, while its path through the deltopectoral groove allows it to contribute to the larger network of veins that drain blood from the upper body.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 10 - A 75-year-old diabetic man comes in with a heart attack and undergoes a...

    Incorrect

    • A 75-year-old diabetic man comes in with a heart attack and undergoes a coronary angiogram. What coronary artery/arteries provide blood supply to the anterior septum of the heart?

      Your Answer:

      Correct Answer: Left Anterior Descending

      Explanation:

      The heart receives blood supply from the coronary arteries, which originate from the left side of the heart at the root of the aorta as it exits the left ventricle.

      The left coronary artery (LCA) provides blood to the left atrium and ventricle, as well as the interventricular septum. The circumflex artery, a branch of the LCA, supplies the lateral aspect of the left heart by following the coronary sulcus to the left. The left anterior descending artery (LAD), another major branch of the LCA, supplies the anteroseptal part of the heart by following the anterior interventricular sulcus around the pulmonary trunk.

      The right coronary artery (RCA) follows the coronary sulcus and supplies blood to the right atrium, portions of both ventricles, and the inferior aspect of the heart. The marginal arteries, which arise from the RCA, provide blood to the superficial portions of the right ventricle. The posterior descending artery, which branches off the RCA on the posterior surface of the heart, runs along the posterior portion of the interventricular sulcus toward the apex of the heart and supplies the interventricular septum and portions of both ventricles.

      The following table displays the relationship between ECG changes and the affected coronary artery territories. Anteroseptal changes in V1-V4 indicate involvement of the left anterior descending artery, while inferior changes in II, III, and aVF suggest the right coronary artery is affected. Anterolateral changes in V4-6, I, and aVL may indicate involvement of either the left anterior descending or left circumflex artery, while lateral changes in I, aVL, and possibly V5-6 suggest the left circumflex artery is affected. Posterior changes in V1-3 may indicate a posterior infarction, which is typically caused by the left circumflex artery but can also be caused by the right coronary artery. Reciprocal changes of STEMI are often seen as horizontal ST depression, tall R waves, upright T waves, and a dominant R wave in V2. Posterior infarction is confirmed by ST elevation and Q waves in posterior leads (V7-9), usually caused by the left circumflex artery but also possibly the right coronary artery. It is important to note that a new LBBB may indicate acute coronary syndrome.

      Diagram showing the correlation between ECG changes and coronary territories in acute coronary syndrome.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 11 - A 25-year-old man is scheduled for cardiac catheterisation to repair a possible atrial...

    Incorrect

    • A 25-year-old man is scheduled for cardiac catheterisation to repair a possible atrial septal defect. What is the typical oxygen saturation level in the right atrium for a person in good health?

      Your Answer:

      Correct Answer: 70%

      Explanation:

      Understanding Oxygen Saturation Levels in Cardiac Catheterisation

      Cardiac catheterisation and oxygen saturation levels can be confusing, but with a few basic rules and logical deduction, it can be easily understood. Deoxygenated blood returns to the right side of the heart through the superior and inferior vena cava with an oxygen saturation level of around 70%. The right atrium, right ventricle, and pulmonary artery also have oxygen saturation levels of around 70%. The lungs oxygenate the blood to a level of around 98-100%, resulting in the left atrium, left ventricle, and aorta having oxygen saturation levels of 98-100%.

      Different scenarios can affect oxygen saturation levels. For instance, in an atrial septal defect (ASD), the oxygenated blood in the left atrium mixes with the deoxygenated blood in the right atrium, resulting in intermediate levels of oxygenation from the right atrium onwards. In a ventricular septal defect (VSD), the oxygenated blood in the left ventricle mixes with the deoxygenated blood in the right ventricle, resulting in intermediate levels of oxygenation from the right ventricle onwards. In a patent ductus arteriosus (PDA), the higher pressure aorta connects with the lower pressure pulmonary artery, resulting in only the pulmonary artery having intermediate oxygenation levels.

      Understanding the expected oxygen saturation levels in different scenarios can help in diagnosing and treating cardiac conditions. The table above shows the oxygen saturation levels that would be expected in different diagnoses, including VSD with Eisenmenger’s and ASD with Eisenmenger’s. By understanding these levels, healthcare professionals can provide better care for their patients.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 12 - A 4-year-old boy is observed by his mother to turn blue around the...

    Incorrect

    • A 4-year-old boy is observed by his mother to turn blue around the lips abruptly after crying. This has occurred several times before and the child promptly assumes the squatting position to alleviate his symptoms. During previous check-ups, the child was found to have various heart issues, including a boot-shaped heart on his chest x-ray.

      What is the probable diagnosis for his condition and what is the underlying cause?

      Your Answer:

      Correct Answer: Failed migration of the neural crest cells

      Explanation:

      The division of the truncus arteriosus into the aorta and pulmonary trunk is dependent on the migration of neural crest cells from the pharyngeal arches. If this process is disrupted, it can lead to Tetralogy of Fallot, which is likely the condition that the patient in question is experiencing. The patient’s frequent ‘tet’ spells and adoption of a squatting position are indicative of this condition, as is the boot-shaped heart seen on chest x-ray due to right ventricular hypertrophy. Other conditions that can result from failed neural crest cell migration include transposition of the great vessels and persistent truncus arteriosus.

      On the other hand, a VSD is associated with a failure of the endocardial cushion, but this would not explain all of the patient’s malformations. Similarly, defects in the ostium primum or secundum would result in an ASD, which is often asymptomatic.

      During cardiovascular embryology, the heart undergoes significant development and differentiation. At around 14 days gestation, the heart consists of primitive structures such as the truncus arteriosus, bulbus cordis, primitive atria, and primitive ventricle. These structures give rise to various parts of the heart, including the ascending aorta and pulmonary trunk, right ventricle, left and right atria, and majority of the left ventricle. The division of the truncus arteriosus is triggered by neural crest cell migration from the pharyngeal arches, and any issues with this migration can lead to congenital heart defects such as transposition of the great arteries or tetralogy of Fallot. Other structures derived from the primitive heart include the coronary sinus, superior vena cava, fossa ovalis, and various ligaments such as the ligamentum arteriosum and ligamentum venosum. The allantois gives rise to the urachus, while the umbilical artery becomes the medial umbilical ligaments and the umbilical vein becomes the ligamentum teres hepatis inside the falciform ligament. Overall, cardiovascular embryology is a complex process that involves the differentiation and development of various structures that ultimately form the mature heart.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 13 - An 80-year-old woman came in with an acute myocardial infarction. The ECG revealed...

    Incorrect

    • An 80-year-old woman came in with an acute myocardial infarction. The ECG revealed ST segment elevation in leads II, III, and aVF. Which coronary artery is the most probable to be blocked?

      Your Answer:

      Correct Answer: Right coronary artery

      Explanation:

      Localisation of Myocardial Infarction

      Myocardial infarction (MI) is a medical emergency that occurs when there is a blockage in the blood flow to the heart muscle. The location of the blockage determines the type of MI and the treatment required. An inferior MI is caused by the occlusion of the right coronary artery, which supplies blood to the bottom of the heart. This type of MI can cause symptoms such as chest pain, shortness of breath, and nausea. It is important to identify the location of the MI quickly to provide appropriate treatment and prevent further damage to the heart muscle. Proper diagnosis and management can improve the patient’s chances of survival and reduce the risk of complications.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 14 - Which of these statements relating to the external carotid is false? ...

    Incorrect

    • Which of these statements relating to the external carotid is false?

      Your Answer:

      Correct Answer: It ends by bifurcating into the superficial temporal and ascending pharyngeal artery

      Explanation:

      The external carotid artery ends by splitting into two branches – the superficial temporal and maxillary branches. It has a total of eight branches, with three located on its anterior surface – the thyroid, lingual, and facial arteries. The pharyngeal artery is a medial branch, while the posterior auricular and occipital arteries are located on the posterior surface.

      Anatomy of the External Carotid Artery

      The external carotid artery begins on the side of the pharynx and runs in front of the internal carotid artery, behind the posterior belly of digastric and stylohyoid muscles. It is covered by sternocleidomastoid muscle and passed by hypoglossal nerves, lingual and facial veins. The artery then enters the parotid gland and divides into its terminal branches within the gland.

      To locate the external carotid artery, an imaginary line can be drawn from the bifurcation of the common carotid artery behind the angle of the jaw to a point in front of the tragus of the ear.

      The external carotid artery has six branches, with three in front, two behind, and one deep. The three branches in front are the superior thyroid, lingual, and facial arteries. The two branches behind are the occipital and posterior auricular arteries. The deep branch is the ascending pharyngeal artery. The external carotid artery terminates by dividing into the superficial temporal and maxillary arteries within the parotid gland.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 15 - A 78-year-old woman with a history of heart failure visits the clinic complaining...

    Incorrect

    • A 78-year-old woman with a history of heart failure visits the clinic complaining of constipation that has lasted for 5 days. Upon further inquiry, she mentions feeling weaker than usual this week and experiencing regular muscle cramps. During the examination, you observe reduced tone and hyporeflexia in both her upper and lower limbs. You suspect that her symptoms may be caused by hypokalaemia, which could be related to the diuretics she takes to manage her heart failure. Which of the following diuretics is known to be associated with hypokalaemia?

      Your Answer:

      Correct Answer: Furosemide

      Explanation:

      Hypokalaemia is a potential side effect of loop diuretics such as furosemide. In contrast, potassium-sparing diuretics like spironolactone, triamterene, eplerenone, and amiloride are more likely to cause hyperkalaemia. The patient in the scenario is experiencing symptoms suggestive of hypokalaemia, including muscle weakness, cramps, and constipation. Hypokalaemia can also cause fatigue, myalgia, hyporeflexia, and in rare cases, paralysis.

      Loop Diuretics: Mechanism of Action and Clinical Applications

      Loop diuretics, such as furosemide and bumetanide, are medications that inhibit the Na-K-Cl cotransporter (NKCC) in the thick ascending limb of the loop of Henle. By doing so, they reduce the absorption of NaCl, resulting in increased urine output. Loop diuretics act on NKCC2, which is more prevalent in the kidneys. These medications work on the apical membrane and must first be filtered into the tubules by the glomerulus before they can have an effect. Patients with poor renal function may require higher doses to ensure sufficient concentration in the tubules.

      Loop diuretics are commonly used in the treatment of heart failure, both acutely (usually intravenously) and chronically (usually orally). They are also indicated for resistant hypertension, particularly in patients with renal impairment. However, loop diuretics can cause adverse effects such as hypotension, hyponatremia, hypokalemia, hypomagnesemia, hypochloremic alkalosis, ototoxicity, hypocalcemia, renal impairment, hyperglycemia (less common than with thiazides), and gout. Therefore, careful monitoring of electrolyte levels and renal function is necessary when using loop diuretics.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 16 - An elderly man in his late 60s is admitted to the cardiology ward...

    Incorrect

    • An elderly man in his late 60s is admitted to the cardiology ward due to worsening shortness of breath. He has a medical history of hypertension and ischaemic heart disease. During examination, bibasal crackles and pitting oedema to the knees bilaterally are observed. Blood tests are conducted, and the results show a brain natriuretic peptide level of 4990 pg/mL (< 400). What is the most probable physiological change that occurs in response to this finding?

      Your Answer:

      Correct Answer: Decreased afterload

      Explanation:

      BNP has several actions, including vasodilation which can decrease cardiac afterload, diuretic and natriuretic effects, and suppression of both sympathetic tone and the renin-angiotensin-aldosterone system. In the case of heart failure, BNP is primarily secreted by the ventricular myocardium to compensate for symptoms by promoting diuresis, natriuresis, vasodilation, and suppression of sympathetic tone and renin-angiotensin-aldosterone activity. Vasodilation of the peripheral vascular system leads to a decrease in afterload, reducing the force that the left ventricle has to contract against and lowering the risk of left ventricular failure progression. BNP also suppresses sympathetic tone and the RAAS, which would exacerbate heart failure symptoms, and contributes to natriuresis, aiding diuresis and improving dyspnea.

      B-type natriuretic peptide (BNP) is a hormone that is primarily produced by the left ventricular myocardium in response to strain. Although heart failure is the most common cause of elevated BNP levels, any condition that causes left ventricular dysfunction, such as myocardial ischemia or valvular disease, may also raise levels. In patients with chronic kidney disease, reduced excretion may also lead to elevated BNP levels. Conversely, treatment with ACE inhibitors, angiotensin-2 receptor blockers, and diuretics can lower BNP levels.

      BNP has several effects, including vasodilation, diuresis, natriuresis, and suppression of both sympathetic tone and the renin-angiotensin-aldosterone system. Clinically, BNP is useful in diagnosing patients with acute dyspnea. A low concentration of BNP (<100 pg/mL) makes a diagnosis of heart failure unlikely, but elevated levels should prompt further investigation to confirm the diagnosis. Currently, NICE recommends BNP as a helpful test to rule out a diagnosis of heart failure. In patients with chronic heart failure, initial evidence suggests that BNP is an extremely useful marker of prognosis and can guide treatment. However, BNP is not currently recommended for population screening for cardiac dysfunction.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 17 - During surgery on her neck, a woman in her 50s suffers a vagus...

    Incorrect

    • During surgery on her neck, a woman in her 50s suffers a vagus nerve injury where the nerve is cut near the exit from the skull. She wakes up with a high heart rate and high blood pressure due to loss of parasympathetic tone.

      What other features would be expected with a vagus nerve injury?

      Your Answer:

      Correct Answer: Hoarse voice

      Explanation:

      The vagus (X) nerve is responsible for all innervation related to speech, meaning that any injuries to this nerve can lead to speech problems. It’s important to note that the vagus nerve has both autonomic and somatic effects, with the latter being the most crucial for speech. This involves the motor supply to the larynx through the recurrent laryngeal nerves, which are branches of the vagus. If one vagus nerve is damaged, it would have the same impact as damage to a single recurrent laryngeal nerve, resulting in a hoarse voice.

      However, it’s worth noting that anal tone, erections, and urination are controlled by the sacral parasympathetics and would not be affected by the loss of the vagus nerve. Similarly, pupillary constriction is controlled by parasympathetics on the oculomotor nerve and would not be impacted by the loss of the vagus nerve.

      The vagus nerve is responsible for a variety of functions and supplies structures from the fourth and sixth pharyngeal arches, as well as the fore and midgut sections of the embryonic gut tube. It carries afferent fibers from areas such as the pharynx, larynx, esophagus, stomach, lungs, heart, and great vessels. The efferent fibers of the vagus are of two main types: preganglionic parasympathetic fibers distributed to the parasympathetic ganglia that innervate smooth muscle of the innervated organs, and efferent fibers with direct skeletal muscle innervation, largely to the muscles of the larynx and pharynx.

      The vagus nerve arises from the lateral surface of the medulla oblongata and exits through the jugular foramen, closely related to the glossopharyngeal nerve cranially and the accessory nerve caudally. It descends vertically in the carotid sheath in the neck, closely related to the internal and common carotid arteries. In the mediastinum, both nerves pass posteroinferiorly and reach the posterior surface of the corresponding lung root, branching into both lungs. At the inferior end of the mediastinum, these plexuses reunite to form the formal vagal trunks that pass through the esophageal hiatus and into the abdomen. The anterior and posterior vagal trunks are formal nerve fibers that splay out once again, sending fibers over the stomach and posteriorly to the coeliac plexus. Branches pass to the liver, spleen, and kidney.

      The vagus nerve has various branches in the neck, including superior and inferior cervical cardiac branches, and the right recurrent laryngeal nerve, which arises from the vagus anterior to the first part of the subclavian artery and hooks under it to insert into the larynx. In the thorax, the left recurrent laryngeal nerve arises from the vagus on the aortic arch and hooks around the inferior surface of the arch, passing upwards through the superior mediastinum and lower part of the neck. In the abdomen, the nerves branch extensively, passing to the coeliac axis and alongside the vessels to supply the spleen, liver, and kidney.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 18 - A 65-year-old man visits the clinic for his regular blood work. The GP...

    Incorrect

    • A 65-year-old man visits the clinic for his regular blood work. The GP requests the medical student to perform venepuncture and obtain blood samples. The student seizes this chance to brush up on their knowledge of vascular anatomy. They plan to draw blood from the median cubital vein located in the antecubital fossa. While aware that the median cubital vein is linked to the cephalic vein, they cannot recall the name of the other vein it connects to. Can you identify the other vein?

      Your Answer:

      Correct Answer: Basilic vein

      Explanation:

      The upper limb has both superficial and deep veins. Among the superficial veins are the cephalic, basilic, and median cubital veins. The median cubital vein, which connects the cephalic and basilic veins, is situated in the antecubital fossa and is the preferred site for venepuncture because it is easy to locate and access. However, deep veins like the brachial, ulnar, and radial veins are not suitable for venepuncture as they are located beneath the deep fascia.

      The Cephalic Vein: Path and Connections

      The cephalic vein is a major blood vessel that runs along the lateral side of the arm. It begins at the dorsal venous arch, which drains blood from the hand and wrist, and travels up the arm, crossing the anatomical snuffbox. At the antecubital fossa, the cephalic vein is connected to the basilic vein by the median cubital vein. This connection is commonly used for blood draws and IV insertions.

      After passing through the antecubital fossa, the cephalic vein continues up the arm and pierces the deep fascia of the deltopectoral groove to join the axillary vein. This junction is located near the shoulder and marks the end of the cephalic vein’s path.

      Overall, the cephalic vein plays an important role in the circulation of blood in the upper limb. Its connections to other major veins in the arm make it a valuable site for medical procedures, while its path through the deltopectoral groove allows it to contribute to the larger network of veins that drain blood from the upper body.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 19 - A 60-year-old woman complains of persistent diarrhoea, wheezing, and flushing. During the physical...

    Incorrect

    • A 60-year-old woman complains of persistent diarrhoea, wheezing, and flushing. During the physical examination, an irregular pulsatile hepatomegaly and a pansystolic murmur that is most pronounced during inspiration are detected. What diagnostic test could provide insight into the probable underlying condition?

      Your Answer:

      Correct Answer: Urinary 5-HIAA (5-hydroxyindole acetic acid)

      Explanation:

      Carcinoid Syndrome and its Diagnosis

      Carcinoid syndrome is characterized by the presence of vasoactive amines such as serotonin in the bloodstream, leading to various clinical features. The primary carcinoid tumor is usually found in the small intestine or appendix, but it may not cause significant symptoms as the liver detoxifies the blood of these amines. However, systemic effects occur when malignant cells spread to other organs, such as the lungs, which are not part of the portal circulation. One of the complications of carcinoid syndrome is damage to the right heart valves, which can cause tricuspid regurgitation, as evidenced by a pulsatile liver and pansystolic murmur.

      To diagnose carcinoid syndrome, the 5-HIAA test is usually performed, which measures the breakdown product of serotonin in a 24-hour urine collection. If the test is positive, imaging and histology are necessary to confirm malignancy.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 20 - A 45-year-old man undergoes a routine medical exam and his blood pressure is...

    Incorrect

    • A 45-year-old man undergoes a routine medical exam and his blood pressure is measured at 155/95 mmHg, which is unusual as it has been normal for the past five annual check-ups. What could be the reason for this sudden change?

      Your Answer:

      Correct Answer: An undersized blood pressure cuff

      Explanation:

      Ensuring Accurate Blood Pressure Measurements

      Blood pressure is a crucial physiological measurement in medicine, and it is essential to ensure that the values obtained are accurate. Inaccurate readings can occur due to various reasons, such as using the wrong cuff size, incorrect arm positioning, and unsupported arms. For instance, using a bladder that is too small can lead to an overestimation of blood pressure, while using a bladder that is too large can result in an underestimation of blood pressure. Similarly, lowering the arm below heart level can lead to an overestimation of blood pressure, while elevating the arm above heart level can result in an underestimation of blood pressure.

      It is recommended to measure blood pressure in both arms when considering a diagnosis of hypertension. If there is a difference of more than 20 mmHg between the readings obtained from both arms, the measurements should be repeated. If the difference remains greater than 20 mmHg, subsequent blood pressures should be recorded from the arm with the higher reading. By following these guidelines, healthcare professionals can ensure that accurate blood pressure measurements are obtained, which is crucial for making informed medical decisions.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 21 - A 50-year-old man is brought to the hospital after a head-on collision. Upon...

    Incorrect

    • A 50-year-old man is brought to the hospital after a head-on collision. Upon initial resuscitation, a chest X-ray reveals a widened mediastinum. An urgent CT aortogram confirms a traumatic aortic rupture.

      Where is the most probable location for a traumatic aortic rupture to occur?

      Your Answer:

      Correct Answer: Proximal descending aorta distal to origin of left subclavian artery (aortic isthmus)

      Explanation:

      Although the aorta can be ruptured by trauma at any location, the aortic isthmus (the section of the proximal descending aorta located below the left subclavian artery) is the most frequent site of rupture resulting from deceleration injuries.

      Thoracic Aorta Rupture: Causes, Symptoms, Diagnosis, and Treatment

      Thoracic aorta rupture is a life-threatening condition that occurs due to decelerating force, such as a road traffic accident or a fall from a great height. Most people die at the scene, while survivors may have an incomplete laceration at the ligamentum arteriosum of the aorta. The clinical features of thoracic aorta rupture include a contained hematoma and persistent hypotension, which can be detected mainly by history and changes in chest X-rays. The X-ray changes include a widened mediastinum, trachea/esophagus to the right, depression of the left main stem bronchus, widened paratracheal stripe/paraspinal interfaces, obliteration of the space between the aorta and pulmonary artery, and rib fracture/left hemothorax.

      The diagnosis of thoracic aorta rupture is usually made through angiography, with CT aortogram being the preferred method. Treatment involves repair or replacement of the ruptured aorta, with endovascular repair being the ideal option. In summary, thoracic aorta rupture is a serious condition that requires prompt diagnosis and treatment to prevent fatal outcomes.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 22 - A 39-year-old woman is being evaluated for progressive dyspnea and is found to...

    Incorrect

    • A 39-year-old woman is being evaluated for progressive dyspnea and is found to have primary pulmonary hypertension. She is prescribed bosentan. What is the mode of action of bosentan?

      Your Answer:

      Correct Answer: Endothelin receptor antagonist

      Explanation:

      Bosentan is an antagonist of the endothelin-1 receptor.

      Pulmonary arterial hypertension (PAH) is a condition where the resting mean pulmonary artery pressure is equal to or greater than 25 mmHg. The pathogenesis of PAH is thought to involve endothelin. It is more common in females and typically presents between the ages of 30-50 years. PAH is diagnosed in the absence of chronic lung diseases such as COPD, although certain factors increase the risk. Around 10% of cases are inherited in an autosomal dominant fashion.

      The classical presentation of PAH is progressive exertional dyspnoea, but other possible features include exertional syncope, exertional chest pain, peripheral oedema, and cyanosis. Physical examination may reveal a right ventricular heave, loud P2, raised JVP with prominent ‘a’ waves, and tricuspid regurgitation.

      Management of PAH should first involve treating any underlying conditions. Acute vasodilator testing is central to deciding on the appropriate management strategy. If there is a positive response to acute vasodilator testing, oral calcium channel blockers may be used. If there is a negative response, prostacyclin analogues, endothelin receptor antagonists, or phosphodiesterase inhibitors may be used. Patients with progressive symptoms should be considered for a heart-lung transplant.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 23 - A 63-year-old woman comes to a vascular clinic complaining of varicosities in the...

    Incorrect

    • A 63-year-old woman comes to a vascular clinic complaining of varicosities in the area supplied by the short saphenous vein.

      Into which vessel does this vein directly empty?

      Your Answer:

      Correct Answer: Popliteal vein

      Explanation:

      The correct answer is that the short saphenous vein passes posterior to the lateral malleolus and ascends between the two heads of the gastrocnemius muscle to empty directly into the popliteal vein. The long saphenous vein drains directly into the femoral vein and does not receive blood from the short saphenous vein. The dorsal venous arch drains the foot into the short and great saphenous veins but does not receive blood from either. The posterior tibial vein is part of the deep venous system but does not directly receive the short saphenous vein.

      The Anatomy of Saphenous Veins

      The human body has two saphenous veins: the long saphenous vein and the short saphenous vein. The long saphenous vein is often used for bypass surgery or removed as a treatment for varicose veins. It originates at the first digit where the dorsal vein merges with the dorsal venous arch of the foot and runs up the medial side of the leg. At the knee, it runs over the posterior border of the medial epicondyle of the femur bone before passing laterally to lie on the anterior surface of the thigh. It then enters an opening in the fascia lata called the saphenous opening and joins with the femoral vein in the region of the femoral triangle at the saphenofemoral junction. The long saphenous vein has several tributaries, including the medial marginal, superficial epigastric, superficial iliac circumflex, and superficial external pudendal veins.

      On the other hand, the short saphenous vein originates at the fifth digit where the dorsal vein merges with the dorsal venous arch of the foot, which attaches to the great saphenous vein. It passes around the lateral aspect of the foot and runs along the posterior aspect of the leg with the sural nerve. It then passes between the heads of the gastrocnemius muscle and drains into the popliteal vein, approximately at or above the level of the knee joint.

      Understanding the anatomy of saphenous veins is crucial for medical professionals who perform surgeries or treatments involving these veins.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 24 - A 20-year-old man experienced recurrent episodes of breathlessness and palpitations lasting approximately 20...

    Incorrect

    • A 20-year-old man experienced recurrent episodes of breathlessness and palpitations lasting approximately 20 minutes and resolving gradually. No unusual physical signs were observed. What is the probable cause of these symptoms?

      Your Answer:

      Correct Answer: Panic attacks

      Explanation:

      Likely Diagnosis for Sudden Onset of Symptoms

      When considering the sudden onset of symptoms, drug abuse is an unlikely cause as the symptoms are short-lived and not accompanied by other common drug abuse symptoms. Paroxysmal SVT would present with sudden starts and stops, rather than a gradual onset. Personality disorder and thyrotoxicosis would both lead to longer-lasting symptoms and other associated symptoms. Therefore, the most likely diagnosis for sudden onset symptoms would be panic disorder. It is important to consider all possible causes and seek medical attention to properly diagnose and treat any underlying conditions.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 25 - A 56-year-old male comes to your clinic complaining of occasional chest pain that...

    Incorrect

    • A 56-year-old male comes to your clinic complaining of occasional chest pain that usually occurs after meals and typically subsides within a few hours. He has a medical history of bipolar disorder, osteoarthritis, gout, and hyperparathyroidism. Currently, he is undergoing a prolonged course of antibiotics for prostatitis.

      During his visit, an ECG reveals a QT interval greater than 520 ms.

      What is the most likely cause of the observed ECG changes?

      - Lithium overdose
      - Paracetamol use
      - Hypercalcemia
      - Erythromycin use
      - Amoxicillin use

      Explanation: The most probable cause of the prolonged QT interval is erythromycin use, which is commonly associated with this ECG finding. Given the patient's medical history, it is likely that he is taking erythromycin for his prostatitis. Amoxicillin is not known to cause QT prolongation. Lithium toxicity typically presents with symptoms such as vomiting, diarrhea, tremors, and agitation. Hypercalcemia is more commonly associated with a short QT interval, making it an unlikely cause. Paracetamol is not known to cause QT prolongation.

      Your Answer:

      Correct Answer: Erythromycin use

      Explanation:

      The prolonged QT interval can be caused by erythromycin.

      It is highly probable that the patient is taking erythromycin to treat his prostatitis, which is the reason for the prolonged QT interval.

      Long QT syndrome (LQTS) is a genetic condition that causes a delay in the ventricles’ repolarization. This delay can lead to ventricular tachycardia/torsade de pointes, which can cause sudden death or collapse. The most common types of LQTS are LQT1 and LQT2, which are caused by defects in the alpha subunit of the slow delayed rectifier potassium channel. A normal corrected QT interval is less than 430 ms in males and 450 ms in females.

      There are various causes of a prolonged QT interval, including congenital factors, drugs, and other conditions. Congenital factors include Jervell-Lange-Nielsen syndrome and Romano-Ward syndrome. Drugs that can cause a prolonged QT interval include amiodarone, sotalol, tricyclic antidepressants, and selective serotonin reuptake inhibitors. Other factors that can cause a prolonged QT interval include electrolyte imbalances, acute myocardial infarction, myocarditis, hypothermia, and subarachnoid hemorrhage.

      LQTS may be detected on a routine ECG or through family screening. Long QT1 is usually associated with exertional syncope, while Long QT2 is often associated with syncope following emotional stress, exercise, or auditory stimuli. Long QT3 events often occur at night or at rest and can lead to sudden cardiac death.

      Management of LQTS involves avoiding drugs that prolong the QT interval and other precipitants if appropriate. Beta-blockers are often used, and implantable cardioverter defibrillators may be necessary in high-risk cases. It is important to note that sotalol may exacerbate LQTS.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 26 - A 70-year-old male inpatient, three days post myocardial infarction, has a sudden onset...

    Incorrect

    • A 70-year-old male inpatient, three days post myocardial infarction, has a sudden onset of intense crushing chest pain.
      What is the most effective cardiac enzyme to determine if this patient has experienced a recurrent heart attack?

      Your Answer:

      Correct Answer: Creatine kinase

      Explanation:

      The Most Useful Enzyme to Measure in Diagnosing Early Re-infarction

      In diagnosing early re-infarction, measuring the levels of creatine kinase is the most useful enzyme to use. This is because the levels of creatine kinase return to normal relatively quickly, unlike the levels of troponins which remain elevated at this stage post MI and are therefore not useful in diagnosing early re-infarction.

      The table above shows the rise, peak, and fall of various enzymes in the body after a myocardial infarction. As seen in the table, the levels of creatine kinase rise within 4-6 hours, peak at 24 hours, and fall within 3-4 days. On the other hand, troponin levels rise within 4-6 hours, peak at 12-16 hours, and fall within 5-14 days. This indicates that measuring creatine kinase levels is more useful in diagnosing early re-infarction as it returns to normal levels faster than troponins.

      In conclusion, measuring the levels of creatine kinase is the most useful enzyme to use in diagnosing early re-infarction. Its levels return to normal relatively quickly, making it a more reliable indicator of re-infarction compared to troponins.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 27 - Which one of the following is typically not provided by the right coronary...

    Incorrect

    • Which one of the following is typically not provided by the right coronary artery?

      Your Answer:

      Correct Answer: The circumflex artery

      Explanation:

      The left coronary artery typically gives rise to the circumflex artery.

      The walls of each cardiac chamber are made up of the epicardium, myocardium, and endocardium. The heart and roots of the great vessels are related anteriorly to the sternum and the left ribs. The coronary sinus receives blood from the cardiac veins, and the aortic sinus gives rise to the right and left coronary arteries. The left ventricle has a thicker wall and more numerous trabeculae carnae than the right ventricle. The heart is innervated by autonomic nerve fibers from the cardiac plexus, and the parasympathetic supply comes from the vagus nerves. The heart has four valves: the mitral, aortic, pulmonary, and tricuspid valves.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 28 - A 56-year-old woman comes to you complaining of severe body aches and pains...

    Incorrect

    • A 56-year-old woman comes to you complaining of severe body aches and pains that have been ongoing for the past 2 weeks. She has been taking atorvastatin for the last 5 years and is aware of its potential side effects, but insists that she has never experienced anything like this before.

      Upon examination, her CK levels are found to be above 3000 U/L. Reviewing her medical records, it is noted that she had a medication review with her cardiologist just 2 weeks ago.

      What could be the possible cause of her current symptoms?

      Your Answer:

      Correct Answer: The cardiologist started her on amiodarone

      Explanation:

      The patient’s symptoms and elevated CK levels suggest that she may have rhabdomyolysis, which is a known risk associated with taking statins while also taking amiodarone. It is likely that her cardiologist prescribed amiodarone. To reduce her risk of statin-induced rhabdomyolysis, her atorvastatin dosage should be lowered.

      It is important to note that digoxin and beta-blockers do not increase the risk of statin-induced rhabdomyolysis, and there is no association between laxatives and this condition.

      Amiodarone is a medication used to treat various types of abnormal heart rhythms. It works by blocking potassium channels, which prolongs the action potential and helps to regulate the heartbeat. However, it also has other effects, such as blocking sodium channels. Amiodarone has a very long half-life, which means that loading doses are often necessary. It should ideally be given into central veins to avoid thrombophlebitis. Amiodarone can cause proarrhythmic effects due to lengthening of the QT interval and can interact with other drugs commonly used at the same time. Long-term use of amiodarone can lead to various adverse effects, including thyroid dysfunction, corneal deposits, pulmonary fibrosis/pneumonitis, liver fibrosis/hepatitis, peripheral neuropathy, myopathy, photosensitivity, a ‘slate-grey’ appearance, thrombophlebitis, injection site reactions, and bradycardia. Patients taking amiodarone should be monitored regularly with tests such as TFT, LFT, U&E, and CXR.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 29 - A 50-year-old patient is admitted to the cardiology department with infective endocarditis. While...

    Incorrect

    • A 50-year-old patient is admitted to the cardiology department with infective endocarditis. While examining the patient's hands, the physician observes a collapsing pulse. What other findings can be expected during the examination?

      Your Answer:

      Correct Answer: Diastolic murmur in the aortic area

      Explanation:

      Aortic regurgitation is often associated with a collapsing pulse, which is a clinical sign. This condition occurs when the aortic valve allows blood to flow back into the left ventricle during diastole. As a result, a diastolic murmur can be heard in the aortic area. While infective endocarditis can cause aortic regurgitation, it can also affect other valves in the heart, leading to a diastolic murmur in the pulmonary area. However, this would not cause a collapsing pulse. A diastolic murmur in the mitral area is indicative of mitral stenosis, which is not associated with a collapsing pulse. Aortic stenosis, which is characterized by restricted blood flow between the left ventricle and aorta, is associated with an ejection systolic murmur in the aortic area, but not a collapsing pulse. Finally, mitral valve regurgitation, which affects blood flow between the left atrium and ventricle, is associated with a pansystolic murmur in the mitral area, but not a collapsing pulse.

      Aortic regurgitation is a condition where the aortic valve of the heart leaks, causing blood to flow in the opposite direction during ventricular diastole. This can be caused by disease of the aortic valve or by distortion or dilation of the aortic root and ascending aorta. The most common causes of AR due to valve disease include rheumatic fever, calcific valve disease, and infective endocarditis. On the other hand, AR due to aortic root disease can be caused by conditions such as aortic dissection, hypertension, and connective tissue diseases like Marfan’s and Ehler-Danlos syndrome.

      The features of AR include an early diastolic murmur, a collapsing pulse, wide pulse pressure, Quincke’s sign, and De Musset’s sign. In severe cases, a mid-diastolic Austin-Flint murmur may also be present. Suspected AR should be investigated with echocardiography.

      Management of AR involves medical management of any associated heart failure and surgery in symptomatic patients with severe AR or asymptomatic patients with severe AR who have LV systolic dysfunction.

    • This question is part of the following fields:

      • Cardiovascular System
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  • Question 30 - A baby is born prematurely at 28 weeks, increasing the likelihood of delayed...

    Incorrect

    • A baby is born prematurely at 28 weeks, increasing the likelihood of delayed closure of the ductus venosus. What are the structures that the ductus venosus connects in the fetus?

      Your Answer:

      Correct Answer: IVC and umbilical vein

      Explanation:

      During fetal development, the ductus venosus redirects blood flow from the left umbilical vein directly to the inferior vena cava, enabling oxygenated blood from the placenta to bypass the fetal liver. Typically, the ductus closes and becomes the ligamentum venosum between day 3 and 7. However, premature infants are more susceptible to delayed closure.

      During cardiovascular embryology, the heart undergoes significant development and differentiation. At around 14 days gestation, the heart consists of primitive structures such as the truncus arteriosus, bulbus cordis, primitive atria, and primitive ventricle. These structures give rise to various parts of the heart, including the ascending aorta and pulmonary trunk, right ventricle, left and right atria, and majority of the left ventricle. The division of the truncus arteriosus is triggered by neural crest cell migration from the pharyngeal arches, and any issues with this migration can lead to congenital heart defects such as transposition of the great arteries or tetralogy of Fallot. Other structures derived from the primitive heart include the coronary sinus, superior vena cava, fossa ovalis, and various ligaments such as the ligamentum arteriosum and ligamentum venosum. The allantois gives rise to the urachus, while the umbilical artery becomes the medial umbilical ligaments and the umbilical vein becomes the ligamentum teres hepatis inside the falciform ligament. Overall, cardiovascular embryology is a complex process that involves the differentiation and development of various structures that ultimately form the mature heart.

    • This question is part of the following fields:

      • Cardiovascular System
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