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  • Question 1 - An analytical cohort study aimed to determine a relationship between intake of dietary...

    Correct

    • An analytical cohort study aimed to determine a relationship between intake of dietary calcium and incidence of hip fractures among post-menopausal women. The following are the data obtained from the study:No. of post-menopausal women who took Calcium: 500No. of post-menopausal women who took Calcium and suffered a hip fracture: 10No. of post-menopausal women who took placebo: 500No. of post-menopausal women who took placebo and suffered a hip fracture: 25Compute for the absolute risk reduction of a hip fracture.

      Your Answer: 0.03

      Explanation:

      Absolute risk reduction (ARR) is computed as the difference between the absolute risk in the control group (ARC) and the absolute risk in the treatment group (ART).ARR = ARC-ARTARR = (25/500) – (10/500)ARR = 0.03

    • This question is part of the following fields:

      • Evidence Based Medicine
      14.2
      Seconds
  • Question 2 - Which of the following is not true regarding the structure and function of...

    Incorrect

    • Which of the following is not true regarding the structure and function of glomerular filtration membrane?

      Your Answer: Filtration slits allow free passage of water and ions

      Correct Answer: The absence of a basement membrane reduces impedance to filtration

      Explanation:

      The glomerular filtration membrane is composed of fenestrated capillary endothelium, basement membrane, and filtration slits. It is an organized, semipermeable membrane preventing the passage of most of the proteins into the urine. The anatomical arrangement of the glomerular filtration membrane maximizes the surface area available for filtration. The arrangement of its arterioles results in high hydrostatic pressures and facilitates filtration. Fenestrated capillary endothelium of the glomerular filtration membrane is with relatively large pores. It allows the free movement of plasma proteins and solutes but still restricts the movement of blood cells. Filtration slits are the smallest filters and restrict the movement of plasma proteins but still allow free movement of ions and nutrients. The glomerular basement membrane (GBM) is a critical component of the glomerular filtration membrane. Thus, it is not true that its absence will reduce the resistance of flow. The basement membrane is true to be more selective and contains negatively charged glycoproteins. However, it still allows free passage of water, nutrients, and ions. Severe structural abnormalities of the GBM can result in protein (albumin) leakage.

    • This question is part of the following fields:

      • Physiology
      • Renal Physiology
      16.7
      Seconds
  • Question 3 - A 55-year-old woman with history of gastritis and reflux esophagitis tested positive for...

    Incorrect

    • A 55-year-old woman with history of gastritis and reflux esophagitis tested positive for Helicobacter pylori infection. Which of the following statements regarding Helicobacter pylori is considered true?

      Your Answer: It is non-motile

      Correct Answer: It is helix shaped

      Explanation:

      Helicobacter pylori is a curved or helix-shaped, non-spore forming, Gram-negative, microaerophilic bacteria. It is motile, having multiple flagella at one pole. It has a lipopolysaccharide component in its outer membrane.

    • This question is part of the following fields:

      • Microbiology
      • Specific Pathogen Groups
      2.6
      Seconds
  • Question 4 - Which of the following is NOT typically present in the nasopharyngeal flora: ...

    Incorrect

    • Which of the following is NOT typically present in the nasopharyngeal flora:

      Your Answer: Neisseria spp.

      Correct Answer: Bacteroides spp.

      Explanation:

      Bacteroides spp. are typically found in the normal flora of the lower gastrointestinal tract. Species commonly found in the flora of the nasopharynx include: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae, Corynebacterium spp., Moraxella spp. and Candida spp.

    • This question is part of the following fields:

      • Microbiology
      • Principles
      2.1
      Seconds
  • Question 5 - All of the following are actions of insulin except: ...

    Correct

    • All of the following are actions of insulin except:

      Your Answer: Increased gluconeogenesis

      Explanation:

      Major Actions of Insulin:↑ Glucose uptake into cells↑ Glycogenesis↓ Glycogenolysis↓ Gluconeogenesis↑ Protein synthesis↓ Protein degradation↑ Fat deposition↓ Lipolysis↓ Ketoacid production↑ K+ uptake into cellsMajor Actions of Glucagon:↓ Glycogenesis↑ Glycogenolysis↑ Gluconeogenesis↓ Fatty acid synthesis↑ Lipolysis↑ Ketoacid production

    • This question is part of the following fields:

      • Endocrine
      • Physiology
      1.2
      Seconds
  • Question 6 - You note that the prostate of a 60-year-old patient is enlarged during the...

    Incorrect

    • You note that the prostate of a 60-year-old patient is enlarged during the examination. You suspect BPH. Anatomically, the prostate has four main lobes. Which of the lobes is affected by benign prostatic hypertrophy?

      Your Answer: Fibromuscular zone

      Correct Answer: Median lobe

      Explanation:

      Benign prostatic hyperplasia (BPH), also known as benign prostatic hypertrophy, is characterized by an enlarged prostate gland. The prostate is divided into four major lobes. The median lobe is the most commonly affected by benign prostatic enlargement, resulting in urethral obstruction and urine symptoms.

    • This question is part of the following fields:

      • Abdomen
      • Anatomy
      13.7
      Seconds
  • Question 7 - Gastrin release from antral G-cells is inhibited by all but which one of...

    Incorrect

    • Gastrin release from antral G-cells is inhibited by all but which one of the following:

      Your Answer: Low gastric pH

      Correct Answer: Vagal stimulation

      Explanation:

      Gastrin secretion is inhibited by:Low gastric pH (negative feedback mechanism)SomatostatinSecretinGastric inhibitory polypeptide (GIP)Cholecystokinin

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      1.3
      Seconds
  • Question 8 - A 10-year-old girl that appears systemically well presents with a honey-crusted scab close...

    Incorrect

    • A 10-year-old girl that appears systemically well presents with a honey-crusted scab close to the corner of her mouth and states that the area is slightly itchy but not painful. The diagnosis given was impetigo.What is most likely the mode of transmission of the causative agent of the said diagnosis?

      Your Answer: Vector transmission

      Correct Answer: Direct contact

      Explanation:

      Impetigo is a common pyoderma that is most often seen in children. Historically, most cases were caused by group A streptococci (GAS; Streptococcus pyogenes), although S. aureus has become the predominant pathogen over the last 15 years.A bullous form of impetigo accounts for approximately 10% of cases. It is caused by strains of S. aureus that produce exfoliative toxins leading to the formation of bullae, which quickly rupture and form a transparent, light brown crust.Impetigo is spread mainly by person-to-person contact; it is rapidly spread through direct transmission. The diagnosis of impetigo can be made from a Gram stain and culture of the vesicular contents.

    • This question is part of the following fields:

      • Microbiology
      • Principles Of Microbiology
      3.3
      Seconds
  • Question 9 - Which of the following statements is correct regarding hyponatraemia? ...

    Correct

    • Which of the following statements is correct regarding hyponatraemia?

      Your Answer: Correction of serum sodium that is too rapid can precipitate central pontine myelinolysis.

      Explanation:

      Hyponatraemia refers to a serum sodium concentration < 135 mmol/L. It is safer to quickly correct acute hyponatremia than chronic hyponatremia but correction should not be too fast, especially in chronic hyponatraemia, because of the risk of central pontine myelinolysis. Hyponatraemia is usually associated with a low plasma osmolality. Under normal circumstances, if serum osmolality is low, then urine osmolality should also be low because the kidneys should be trying to retain solute. In SIADH, excess ADH causes water retention, but not the retention of solute. Therefore, urine that is concentrated and relatively high in sodium is produced, even though the serum sodium is low (urine osmolality > 100 mosmol/kg).

    • This question is part of the following fields:

      • Endocrine
      • Physiology
      0.6
      Seconds
  • Question 10 - Regarding antacids, which of the following statements is CORRECT: ...

    Incorrect

    • Regarding antacids, which of the following statements is CORRECT:

      Your Answer: Antacids act to inhibit H2-receptors on gastric parietal cells.

      Correct Answer: Antacids should not be taken at the same time as other drugs as they impair absorption.

      Explanation:

      Antacids should preferably not be taken at the same time as other drugs since they may impair absorption. Antacids act by neutralising stomach acid. They are used for symptomatic relief in dyspepsia, but are not first line for proven peptic ulcer disease where antisecretory drugs have a better healing effect. Magnesium-containing antacids tend to be laxative whereas aluminium-containing antacids tend to be constipating. Antacids are contraindicated in hypophosphataemia.

    • This question is part of the following fields:

      • Gastrointestinal
      • Pharmacology
      0.5
      Seconds
  • Question 11 - Which of the following is NOT a typical effect of cortisol: ...

    Correct

    • Which of the following is NOT a typical effect of cortisol:

      Your Answer: Decreased protein catabolism

      Explanation:

      Cortisol is a steroid hormone produced in the zona fasciculata of the adrenal cortex. It is released in response to stress and low blood glucose concentrations.Cortisol acts to: raise plasma glucose by stimulating glycolysis and gluconeogenesis in the liver and inhibiting peripheral glucose uptake into storage tissues, increase protein breakdown in skeletal muscle, skin and bone to release amino acids, increase lipolysis from adipose tissues to release fatty acidsand at higher levels and mimic the actions of aldosterone on the kidney to retain Na+ and water and lose K+ ionssuppress the action of immune cells

    • This question is part of the following fields:

      • Endocrine
      • Physiology
      0.6
      Seconds
  • Question 12 - Which of the following drugs is first line treatment for a stable regular...

    Incorrect

    • Which of the following drugs is first line treatment for a stable regular broad-complex tachycardia:

      Your Answer: Flecainide

      Correct Answer: Amiodarone

      Explanation:

      A regular broad-complex tachycardia is likely to be ventricular tachycardia or a regular supraventricular rhythm with bundle branch block. A ventricular tachycardia (or broad-complex tachycardia of uncertain origin) should be treated with amiodarone 300 mg IV over 10 – 60 min, followed by an infusion of 900 mg over the next 24 hours. If previously confirmed as SVT with bundle branch block, the patient should be treated as for narrow-complex tachycardia.

    • This question is part of the following fields:

      • Cardiovascular
      • Pharmacology
      0.6
      Seconds
  • Question 13 - A tumour compresses the jugular foramen of a 50-year-old patient. Compression of several...

    Incorrect

    • A tumour compresses the jugular foramen of a 50-year-old patient. Compression of several nerves in the jugular foramen will result in which of the following complications?

      Your Answer: Loss of sensation over the face

      Correct Answer: Loss of gag reflex

      Explanation:

      The glossopharyngeal nerve, which is responsible for the afferent pathway of the gag reflex, the vagus nerve, which is responsible for the efferent pathway of the gag reflex, and the spinal accessory nerve all exit the skull through the jugular foramen. These nerves are most frequently affected if the jugular foramen is compressed. As a result, the patient’s gag reflex is impaired. The vestibulocochlear nerve is primarily responsible for hearing. The trigeminal nerve provides sensation in the face. The facial nerve innervates the muscles of face expression (including those responsible for closing the eye). Tongue motions are controlled mostly by the hypoglossal nerve.

    • This question is part of the following fields:

      • Anatomy
      • Cranial Nerve Lesions
      0.5
      Seconds
  • Question 14 - A patient presents to ED complaining of pins and needles over the lateral...

    Incorrect

    • A patient presents to ED complaining of pins and needles over the lateral three and a half digits. You suspect carpal tunnel syndrome. Which of the following clinical features would you most expect to see on examination:

      Your Answer: Inability to flex the distal interphalangeal joint of the index finger

      Correct Answer: Inability to touch the pad of the little finger with the thumb

      Explanation:

      Compression of the median nerve in the carpal tunnel will result in weakness and atrophy of the thenar muscles – resulting in weakness of opposition, abduction and flexion of the thumb at the metacarpophalangeal joint and anaesthesia or paraesthesia over the distribution of the palmar digital branch of the median nerve (skin over the palmar surface and fingertips of the lateral three and a half digits). The adductor pollicis muscle is innervated by the ulnar nerve, and abduction of the fingers is produced by the interossei, also innervated by the ulnar nerve. Flexion of the interphalangeal joint of the thumb is produced by the flexor pollicis longus, and flexion of the distal interphalangeal joint of the index finger is produced by the flexor digitorum profundus. Median nerve injury at the wrist will not affect the long flexors of the forearm as these are innervated by the anterior interosseous nerve which arises in the proximal forearm.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      0.6
      Seconds
  • Question 15 - A 29-year-old female with a swollen red finger presents to your clinic and...

    Incorrect

    • A 29-year-old female with a swollen red finger presents to your clinic and you suspect that the underlying process is of acute inflammation. You request for some bloods investigations.Which statement about histamine as a chemical mediator of the acute inflammatory response is TRUE?

      Your Answer: It causes vasoconstriction

      Correct Answer: It increases vascular permeability

      Explanation:

      Histamine increases vascular permeability in the acute inflammatory response.Histamine causes vasodilation.It is released from Mast cells and basophils, eosinophils and platelets. Mast cells and basophils are its primary source Nitric oxide (not histamine) is a major factor in endotoxic shock

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      1.2
      Seconds
  • Question 16 - A patient suffers a stab wound to the neck. The entry point of...

    Correct

    • A patient suffers a stab wound to the neck. The entry point of the blade is situated within the anterior triangle of the neck.Which of the following muscles is most likely to be involved? Select ONE answer only.

      Your Answer: Sternothyroid

      Explanation:

      The anterior triangle is the triangular area of the neck found anteriorly to the sternocleidomastoid muscle. It is formed by the anterior border of sternocleidomastoid laterally, the median line of the neck medially and by the inferior border of the mandible superiorly. The apex of the anterior triangle extends towards the manubrium sterni. The anterior triangle contains:Muscles: thyrohyoid, sternothyroid, sternohyoid musclesOrgans: thyroid gland, parathyroid glands, larynx, trachea, esophagus, submandibular gland, caudal part of the parotid glandArteries: superior and inferior thyroid, common carotid, external carotid, internal carotid artery (and sinus), facial, submental, lingual arteriesVeins: anterior jugular veins, internal jugular, common facial, lingual, superior thyroid, middle thyroid veins, facial vein, submental vein, lingual veinsNerves: vagus nerve (CN X), hypoglossal nerve (CN XII), part of sympathetic trunk, mylohyoid nerveThe posterior triangle is a triangular area found posteriorly to the sternocleidomastoid muscle. It has three borders; anterior, posterior and inferior borders. The anterior border is the posterior margin of the sternocleidomastoid muscle. The posterior border is the anterior margin of the trapezius muscle, while the inferior border is the middle one-third of the clavicle. The investing layer of deep cervical fascia and integument forms the roof of the space, while the floor is covered with the prevertebral fascia along with levator scapulae, splenius capitis and the scalene muscles. The inferior belly of omohyoid subdivides the posterior triangle into a small supraclavicular, and a large occipital, triangle.Contents:Vessels: the third part of the subclavian artery, suprascapular and transverse cervical branches of the thyrocervical trunk, external jugular vein, lymph nodesNerves: accessory nerve (CN XI), the trunks of the brachial plexus, fibers of the cervical plexus

    • This question is part of the following fields:

      • Anatomy
      • Head And Neck
      0.4
      Seconds
  • Question 17 - A lesion to which part of the optic radiation will result in contralateral...

    Correct

    • A lesion to which part of the optic radiation will result in contralateral homonymous inferior quadrantanopia?

      Your Answer: Right parietal lobe

      Explanation:

      A visual loss in the lower left quadrant in both visual fields is an indication of an inferior homonymous. This is due to a lesion of the superior fibres of the optic radiation in the parietal lobe on the contralateral side of the visual pathway.

    • This question is part of the following fields:

      • Anatomy
      • Central Nervous System
      1.2
      Seconds
  • Question 18 - A 34-year-old man arrives at the department befuddled. He has a history of...

    Correct

    • A 34-year-old man arrives at the department befuddled. He has a history of schizophrenia and is on an antipsychotic medication, but he can't recall what it's called.Which of the following statements about antipsychotic drug side effects is correct?

      Your Answer: Haloperidol is the most common causative antipsychotic drug

      Explanation:

      Extrapyramidal side effects are most common with piperazine phenothiazines (fluphenazine, prochlorperazine, and trifluoperazine) and butyrophenones (fluphenazine, prochlorperazine, and trifluoperazine) (benperidol and haloperidol). The most common causative antipsychotic drug is haloperidol.Tardive dyskinesia (rhythmic, involuntary movements of the tongue, face, and jaw) is most commonly associated with long-term or high-dose treatment. It is the most serious form of extrapyramidal symptoms because withdrawal of the causative drug may make it irreversible, and treatment is usually ineffective.Dystonia (abnormal facial and body movements) is more common in children and young adults, and it usually shows up after only a few doses. Procyclidine 5 mg IV or benzatropine 2 mg IV as a bolus can be used to treat acute dystonia.An unpleasant feeling of restlessness characterises akathisia. The inability to initiate movement is known as akinesia.Renal impairment causes increased cerebral sensitivity, so lower doses should be used.In elderly patients with dementia-related psychosis who are treated with haloperidol, there is an increased risk of death. This appears to be due to a higher risk of heart attacks and infections like pneumonia.The following are some of the antipsychotic drugs’ contraindications:Reduced level of consciousness/comaDepression of the central nervous systemPhaeochromocytoma

    • This question is part of the following fields:

      • CNS Pharmacology
      • Pharmacology
      0.5
      Seconds
  • Question 19 - Regarding haemoglobin, which of the following statements is INCORRECT: ...

    Correct

    • Regarding haemoglobin, which of the following statements is INCORRECT:

      Your Answer: Haemoglobin synthesis occurs in mature erythrocytes.

      Explanation:

      Haemoglobin is composed of four polypeptide globin chains each with its own iron containing haem molecule. Haem synthesis occurs largely in the mitochondria by a series of biochemical reactions commencing with the condensation of glycine and succinyl coenzyme A under the action of the key rate-limiting enzyme delta-aminolevulinic acid (ALA) synthase. The globin chains are synthesised by ribosomes in the cytosol. Haemoglobin synthesis only occurs in immature red blood cells.There are three types of haemoglobin in normal adult blood: haemoglobin A, A2 and F:- Normal adult haemoglobin (HbA) makes up about 96 – 98 % of total adult haemoglobin, and consists of two alpha (α) and two beta (β) globin chains. – Haemoglobin A2 (HbA2), a normal variant of adult haemoglobin, makes up about 1.5 – 3.5 % of total adult haemoglobin and consists of two α and two delta (δ) globin chains.- Foetal haemoglobin is the main Hb in the later two-thirds of foetal life and in the newborn until approximately 12 weeks of age. Foetal haemoglobin has a higher affinity for oxygen than adult haemoglobin. Red cells are destroyed by macrophages in the liver and spleen after , 120 days. The haem group is split from the haemoglobin and converted to biliverdin and then bilirubin. The iron is conserved and recycled to plasma via transferrin or stored in macrophages as ferritin and haemosiderin. An increased rate of haemoglobin breakdown results in excess bilirubin and jaundice.

    • This question is part of the following fields:

      • Basic Cellular
      • Physiology
      0.6
      Seconds
  • Question 20 - What kind of function loss do you anticipate in a 22-year-old guy who...

    Incorrect

    • What kind of function loss do you anticipate in a 22-year-old guy who had a laceration to his arm, resulting in nerve damage in the antecubital fossa?

      Your Answer: Extension of fingers

      Correct Answer: Opposition of thumb

      Explanation:

      The symptoms of median nerve injury include tingling or numbness in the forearm, thumb, and three adjacent fingers, as well as gripping weakness and the inability to move the thumb across the palm. Because the thenar muscles and the flexor pollicis longus are paralyzed, flexion, abduction, and opposition of the thumb at the MCPJ and IPJ are gone.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      0.5
      Seconds
  • Question 21 - A 72 year old man is brought to ED by ambulance with sudden...

    Incorrect

    • A 72 year old man is brought to ED by ambulance with sudden onset chest pain, palpitations and shortness of breath. His HR is 160 bpm and BP 90/65. ECG demonstrates new-onset fast atrial fibrillation. Which of the following is the first-line treatment option in this case:

      Your Answer: Beta-blocker

      Correct Answer: Synchronised DC cardioversion

      Explanation:

      All patients with adverse features suggesting life-threatening haemodynamic instability (shock, syncope, heart failure, myocardial ischaemia) caused by new onset atrial fibrillation should undergo emergency electrical cardioversion with synchronised DC shock without delaying to achieve anticoagulation.

    • This question is part of the following fields:

      • Cardiovascular
      • Pharmacology
      0.8
      Seconds
  • Question 22 - A 72-year-old man presents with chest pain that is characteristic of angina. You...

    Incorrect

    • A 72-year-old man presents with chest pain that is characteristic of angina. You administer a dose of glyceryl trinitrate (GTN), which rapidly resolved his symptoms. Unfortunately, he also develops an unpleasant side effect.Which of the following side effects is he most likely to have developed? Select ONE answer only.

      Your Answer: Dry eyes

      Correct Answer: Headache

      Explanation:

      Nitrates are used in the treatment of angina pectoris and the prevention of myocardial ischaemia. Commonly used examples of nitrates are glyceryl trinitrate and isosorbide dinitrate. Unwanted effects, however, are common and can limit therapy, particularly when angina is severe or when patients are unusually sensitive to the effects of nitrates.The following are common or very common side effects of nitratesArrhythmiasAstheniaCerebral ischaemiaDizzinessDrowsinessFlushingHeadacheHypotensionNausea and vomitingDiarrhoea, syncope and cyanosis can occur, but these are rare side effects. Dry eyes, bradycardia and metabolic acidosis have not been reported.

    • This question is part of the following fields:

      • Cardiovascular Pharmacology
      • Pharmacology
      0.5
      Seconds
  • Question 23 - Regarding the flexor digitorum profundus muscle, which of the following is true? ...

    Incorrect

    • Regarding the flexor digitorum profundus muscle, which of the following is true?

      Your Answer: The entire muscle is innervated by the median nerve

      Correct Answer: The medial aspect of the muscle is innervated by the ulnar nerve

      Explanation:

      Flexor digitorum profundus is a fusiform muscle located deep within the anterior (flexor) compartment of the forearm. Along with the flexor pollicis longus and pronator quadratus muscles, it comprises the deep flexor compartment of the forearm.Flexor digitorum profundus has a dual innervation:(1) The medial part of the muscle, that inserts to the fourth and fifth digits, is innervated by the ulnar nerve (C8-T1);(2) The lateral part, that inserts to the second and third digits, is innervated by the median nerve, via anterior interosseous branch (C8-T1).

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      0.7
      Seconds
  • Question 24 - Beta cells of the endocrine pancreas produce which of the following hormones: ...

    Incorrect

    • Beta cells of the endocrine pancreas produce which of the following hormones:

      Your Answer: Glucagon

      Correct Answer: Insulin

      Explanation:

      Insulin is produced by beta cells, located centrally within the islets of Langerhans, in the endocrine tissues of the pancreas. Insulin is a polypeptide hormone consisting of two short chains (A and B) linked by disulphide bonds. Proinsulin is synthesised as a single-chain peptide. Within storage granules, a connecting peptide (C peptide) is removed by proteases to yield insulin. Insulin release is stimulated initially during eating by the parasympathetic nervous system and gut hormones such as secretin, but most output is driven by the rise in plasma glucose concentration that occurs after a meal. The effects of insulin are mediated by the receptor tyrosine kinase.

    • This question is part of the following fields:

      • Endocrine
      • Physiology
      0.8
      Seconds
  • Question 25 - Where is angiotensin I primarily converted to angiotensin II: ...

    Incorrect

    • Where is angiotensin I primarily converted to angiotensin II:

      Your Answer: Kidneys

      Correct Answer: Lungs

      Explanation:

      Angiotensin I is converted to angiotensin II by the removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE). This primarily occurs in the lungs, although it does also occur to a lesser degree in endothelial cells and renal epithelial cells.The main actions of angiotensin II are:Vasoconstriction of vascular smooth muscle (resulting in increased blood pressure)Vasoconstriction of the efferent arteriole of the glomerulus (resulting in an increased filtration fraction and preserved glomerular filtration rate)Stimulation of aldosterone release from the zona glomerulosa of the adrenal cortexStimulation of anti-diuretic hormone (vasopressin) release from the posterior pituitaryStimulation of thirst via the hypothalamusActs on the Na+/H+ exchanger in the proximal tubule of the kidney to stimulate Na+reabsorption and H+excretion

    • This question is part of the following fields:

      • Physiology
      • Renal
      0.6
      Seconds
  • Question 26 - Regarding drug interactions with erythromycin, which of the following statements is INCORRECT: ...

    Incorrect

    • Regarding drug interactions with erythromycin, which of the following statements is INCORRECT:

      Your Answer: Erythromycin increases plasma levels of carbamazepine.

      Correct Answer: Erythromycin decreases plasma levels of warfarin.

      Explanation:

      Erythromycin and clarithromycin inhibit cytochrome P450-mediated metabolism of warfarin, phenytoin and carbamazepine and may lead to accumulation of these drugs. There is an increased risk of myopathy (due to cytochrome P450 enzyme CYP3A4 inhibition) if erythromycin or clarithromycin is taken with atorvastatin or simvastatin. Erythromycin increases plasma concentrations of theophylline, and theophylline may also reduce absorption of oral erythromycin. All macrolides can prolong the QT-interval and concomitant use of drugs that prolong the QT interval is not recommended.

    • This question is part of the following fields:

      • Infections
      • Pharmacology
      1.6
      Seconds
  • Question 27 - Regarding Clostridium tetani, which of the following statements is CORRECT: ...

    Incorrect

    • Regarding Clostridium tetani, which of the following statements is CORRECT:

      Your Answer: Infection is usually endogenous.

      Correct Answer: Infection is predominantly derived from animal faeces and soil.

      Explanation:

      Clostridium tetaniis a Gram positive, rod shaped, obligate anaerobic bacterium.The incubation period is quoted as anywhere between 4-21 days and can occur after several months but symptoms usually occur within the first 7 days after exposure.Approximately 80% of patients develop generalised tetanus. The commonest presenting feature of generalised tetanus is trismus (lockjaw), occurring in approximately 75% of affected individuals. Other clinical features include:Facial spasms (risus sardonicus)Opisthotonus (characteristic body shape during spasms)Neck stiffnessDysphagiaCalf and pectoral muscle rigidityFeverHypertensionTachycardiaSpasms can occur frequently and last for several minutes, they can continue to occur for up to 4 weeks. Current mortality rates are between 10 and 15%.Tetanic spasms are caused by the exotoxin tetanospasmin. The effects of tetanolysin are not fully understood but it is not believed to have clinical significance.Localised tetanus is a rare form of the disease, occurring in around 1% of affected individuals. Patients have persistent contraction of muscles in the same anatomic area as the injury. It may precede generalised tetanus.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      0.7
      Seconds
  • Question 28 - Pressure across the wall of a flexible tube (the transmural pressure) increases wall...

    Incorrect

    • Pressure across the wall of a flexible tube (the transmural pressure) increases wall tension and extends it.Which law best describes transmural pressure?

      Your Answer: Fick’s law

      Correct Answer: Laplace’s law

      Explanation:

      The transmural pressure (pressure across the wall of a flexible tube) can be described by Laplace’s law which states that:Transmural pressure = (Tw) / rWhere:T = Wall tensionw = Wall thicknessr = The radiusA small bubble with the same wall tension as a larger bubble will contain higher pressure and will collapse into the larger bubble if the two meet and join.Fick’s law describes the rate of diffusion in a solutionPoiseuille’s law is used to calculate volume of flow rate in laminar flowDarcy’s law describes the flow of a fluid through a porous medium.Starling’s law describes cardiac haemodynamics as it relates to myocyte contractility and stretch.

    • This question is part of the following fields:

      • Basic Cellular Physiology
      • Physiology
      0.5
      Seconds
  • Question 29 - A dermatological examination on a patient presenting with a lump shows a small...

    Incorrect

    • A dermatological examination on a patient presenting with a lump shows a small visible skin elevation containing an accumulation of pus.Which one of these best describes the lump you have found on examination?

      Your Answer: Furuncle

      Correct Answer: Pustule

      Explanation:

      A pustule is a small visible skin elevation containing an accumulation of pus. A carbuncle is a collection of individual boils clustered together. A bulla is a visible collection of clear fluid measuring greater than 0.5 cm in diameter. A furuncle, or boil, is a pyogenic infection of the hair follicle commonly caused by infection with Staphylococcus aureus. A vesicle is a visible collection of fluid measuring less than 0.5 cm in diameter.

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      1.2
      Seconds
  • Question 30 - A patient with a high potassium level is at risk of going into...

    Incorrect

    • A patient with a high potassium level is at risk of going into cardiac arrest. What changes in the ECG may indicate the incident of cardiac arrest in this patient?

      Your Answer: Short PR interval or absent p waves

      Correct Answer: Peaked T waves and broad QRS complex

      Explanation:

      Severe hyperkalaemia can result in a heart attack or a life-threatening arrhythmia. T waves become narrow-based, pointed, and tall if hyperkalaemia is not treated. The QRS complex widens and eventually merges with the T wave, resulting in a classic sine-wave electrocardiogram. Ventricular fibrillation and asystole are likely to follow.

    • This question is part of the following fields:

      • Physiology
      • Renal
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SESSION STATS - PERFORMANCE PER SPECIALTY

Abdomen (1/1) 100%
Anatomy (3/7) 43%
Gastrointestinal (1/2) 50%
Physiology (4/10) 40%
Microbiology (0/4) 0%
Principles Of Microbiology (0/1) 0%
Endocrine (1/4) 25%
Pharmacology (1/6) 17%
Cardiovascular (0/2) 0%
Cranial Nerve Lesions (0/1) 0%
Upper Limb (0/3) 0%
General Pathology (1/2) 50%
Pathology (1/2) 50%
Head And Neck (1/1) 100%
Central Nervous System (1/1) 100%
CNS Pharmacology (0/1) 0%
Basic Cellular (1/1) 100%
Cardiovascular Pharmacology (0/1) 0%
Renal (2/2) 100%
Infections (0/1) 0%
Pathogens (0/1) 0%
Basic Cellular Physiology (0/1) 0%
Evidence Based Medicine (0/1) 0%
Renal Physiology (0/1) 0%
Specific Pathogen Groups (0/1) 0%
Principles (0/1) 0%
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