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  • Question 1 - A father brings his 4-year-old daughter to your GP surgery. He has noticed...

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    • A father brings his 4-year-old daughter to your GP surgery. He has noticed that she has been scratching her face, particularly around her mouth and that she has developed some 'spots and scabs' in the area. The patient doesn't appear systemically unwell or distressed. The child has a history of atopic eczema and viral-induced wheeze.

      On examination of the child's face you note the presence of pustules and vesicles surrounding the mouth and nose area along with some honey-coloured plaques. You diagnose impetigo and prescribe topical fusidic acid as well as advising good hygiene measures.

      The father is concerned about sending the child to preschool. What do you advise?

      Your Answer: The patient must have been on treatment for 48h before returning to daycare

      Explanation:

      Patients with impetigo can go back to school or work once they are no longer contagious, which is either when all lesions have crusted over or after 48 hours of starting treatment. For measles or rubella, it is recommended to wait for at least 4 days after the rash appears before returning to work or school.

      Understanding Impetigo: Causes, Symptoms, and Management

      Impetigo is a common bacterial skin infection that is caused by either Staphylococcus aureus or Streptococcus pyogenes. It can occur as a primary infection or as a complication of an existing skin condition such as eczema. Impetigo is most common in children, especially during warm weather. The infection can develop anywhere on the body, but it tends to occur on the face, flexures, and limbs not covered by clothing.

      The infection spreads through direct contact with discharges from the scabs of an infected person. The bacteria invade the skin through minor abrasions and then spread to other sites by scratching. Infection is spread mainly by the hands, but indirect spread via toys, clothing, equipment, and the environment may occur. The incubation period is between 4 to 10 days.

      Symptoms of impetigo include ‘golden’, crusted skin lesions typically found around the mouth. It is highly contagious, and children should be excluded from school until the lesions are crusted and healed or 48 hours after commencing antibiotic treatment.

      Management of impetigo depends on the extent of the disease. Limited, localized disease can be treated with hydrogen peroxide 1% cream or topical antibiotic creams such as fusidic acid or mupirocin. MRSA is not susceptible to either fusidic acid or retapamulin, so topical mupirocin should be used in this situation. Extensive disease may require oral flucloxacillin or oral erythromycin if penicillin-allergic. The use of hydrogen peroxide 1% cream was recommended by NICE and Public Health England in 2020 to cut antibiotic resistance. The evidence base shows it is just as effective at treating non-bullous impetigo as a topical antibiotic.

    • This question is part of the following fields:

      • Dermatology
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  • Question 2 - An 80-year-old woman has been consulting with the practice nurse for a few...

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    • An 80-year-old woman has been consulting with the practice nurse for a few weeks about a leg ulcer on her right leg that doesn't seem to be healing despite multiple rounds of antibiotics. You schedule some Doppler tests, which reveal an ankle: brachial pressure index (ABPI) of 0.4 in the affected leg and 0.8 in the other leg. A wound swab indicates the presence of coliforms. What is the most probable diagnosis from the options provided?

      Your Answer: Arterial insufficiency

      Explanation:

      Understanding the Ankle-Brachial Pressure Index (ABPI) and its Role in Diagnosing Peripheral Arterial Disease

      The ankle-brachial pressure index (ABPI) is a crucial diagnostic tool for identifying peripheral arterial disease. By comparing the systolic blood pressure at the ankle to the brachial artery pressure, doctors can determine if there is lower blood pressure in the leg, which is a sign of arterial disease. To measure the ABPI, a Doppler ultrasound blood flow detector and a sphygmomanometer are used to detect the artery pulse in the brachial and dorsalis pedis or posterior tibial arteries.

      A normal ABPI falls between 0.9 and 1.2, while a value below 0.9 indicates arterial disease. An ABPI of 1.3 or greater is considered abnormal and suggests severe arterial disease. In cases where the ABPI is below 0.5, the disease is considered severe. It’s important to note that an ulcer with a normal ABPI is most likely a venous ulcer.

      While coliforms are common commensals in leg ulcers and typically don’t require treatment, failure of any ulcer to heal should raise concerns about the possibility of a squamous cell carcinoma. Vasculitis typically doesn’t affect the ABPI unless it’s a large vessel vasculitis, such as polyarteritis nodosa, which would be apparent. Understanding the ABPI and its role in diagnosing peripheral arterial disease is crucial for effective treatment and management of this condition.

    • This question is part of the following fields:

      • Dermatology
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  • Question 3 - A 35-year-old woman, who is typically healthy, presents with a pruritic rash. She...

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    • A 35-year-old woman, who is typically healthy, presents with a pruritic rash. She is currently pregnant with twins at 32/40 gestation and this is her first pregnancy. The rash initially appeared on her abdomen and has predominantly affected her stretch marks. Upon examination, she displays urticarial papules with some plaques concentrated on the abdomen, while the umbilical area remains unaffected. What is the probable diagnosis?

      Your Answer: Polymorphic eruption of pregnancy

      Explanation:

      The cause of itch during pregnancy can be identified by observing the timing of symptoms and the appearance of the rash. Polymorphic eruption of pregnancy is a common condition that usually occurs in the third trimester and is more likely to affect first-time pregnant women with excessive weight gain or multiple pregnancies. The rash is characterized by itchy urticarial papules that merge into plaques and typically starts on the abdomen, particularly on the striae, but not on the umbilicus region. The rash may remain localized, spread to the buttocks and thighs, or become widespread and generalized. It may later progress to non-urticated erythema, eczematous lesions, and vesicles, but not bullae.

      Skin Disorders Associated with Pregnancy

      During pregnancy, women may experience various skin disorders. The most common skin disorder found in pregnancy is atopic eruption, which presents as an itchy red rash. However, no specific treatment is needed for this condition. Another skin disorder is polymorphic eruption, which is a pruritic condition associated with the last trimester. Lesions often first appear in abdominal striae, and management depends on severity. Emollients, mild potency topical steroids, and oral steroids may be used. Pemphigoid gestationis is another skin disorder that presents as pruritic blistering lesions. It often develops in the peri-umbilical region, later spreading to the trunk, back, buttocks, and arms. This disorder usually presents in the second or third trimester and is rarely seen in the first pregnancy. Oral corticosteroids are usually required for treatment.

    • This question is part of the following fields:

      • Dermatology
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  • Question 4 - A 72-year-old obese woman presents with a leg ulcer. This followed a superficial...

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    • A 72-year-old obese woman presents with a leg ulcer. This followed a superficial traumatic abrasion a month ago that never healed. She has a past history of ischaemic heart disease. Examination reveals a 5cm ulcer over the left shin; it is superficial with an irregular border and slough in the base. There is mild pitting oedema and haemosiderin deposition bilaterally on the legs. The ipsilateral foot pulses are weakly palpable.
      Which diagnosis fits best with this clinical picture?

      Your Answer: Venous ulcer

      Explanation:

      Differentiating Venous Ulcers from Other Types of Leg Ulcers

      Venous leg ulcers are a common type of leg ulcer in the UK, accounting for around 3% of all new cases attending dermatology clinics. These ulcers are typically large and superficial, and are accompanied by signs of chronic venous insufficiency. This condition leads to venous stasis and increased capillary pressure, resulting in secondary skin changes whose mechanisms are not well understood. Predisposing factors to venous insufficiency include obesity, history of varicose veins, leg trauma, and deep vein thrombosis.

      In contrast, arterial ulcers are typically small and punched out, occurring most commonly over a bony prominence such as a malleolus or on the toes. Bowen’s disease, a form of squamous cell carcinoma in situ, commonly occurs on the legs in women but would not reach a size of 5cm in only a month. Neuropathic ulcers, on the other hand, occur on the feet in the context of peripheral neuropathy. Vasculitic ulcers are also a possibility, but there are no clues in the history or findings to suggest their presence.

      To differentiate venous ulcers from other types of leg ulcers, it is important to look for corroborating signs of chronic venous insufficiency, such as peripheral edema, venous eczema, haemosiderin deposition, lipodermatosclerosis, and atrophie blanche. Workup should include measurement of the ankle brachial pressure indices (ABPIs) to exclude coexistent arterial disease. If the ABPIs are satisfactory, the cornerstone of management is compression.

    • This question is part of the following fields:

      • Dermatology
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  • Question 5 - A 30-year-old female presents with tender, erythematous nodules over her thighs. Blood tests...

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    • A 30-year-old female presents with tender, erythematous nodules over her thighs. Blood tests reveal:

      Calcium 2.78 mmol/l

      What is the most probable diagnosis?

      Your Answer: Erythema nodosum

      Explanation:

      Understanding Erythema Nodosum

      Erythema nodosum is a condition characterized by inflammation of the subcutaneous fat, resulting in tender, erythematous, nodular lesions. These lesions typically occur over the shins but may also appear on other parts of the body, such as the forearms and thighs. Fortunately, erythema nodosum usually resolves within six weeks, and the lesions heal without scarring.

      There are several potential causes of erythema nodosum. Infections such as streptococci, tuberculosis, and brucellosis can trigger the condition. Systemic diseases like sarcoidosis, inflammatory bowel disease, and Behcet’s syndrome may also be responsible. In some cases, erythema nodosum may be linked to malignancy or lymphoma. Certain drugs, including penicillins, sulphonamides, and the combined oral contraceptive pill, as well as pregnancy, can also cause erythema nodosum.

      Overall, understanding the potential causes of erythema nodosum can help individuals recognize the condition and seek appropriate treatment. While the condition can be uncomfortable, it typically resolves on its own within a few weeks.

    • This question is part of the following fields:

      • Dermatology
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  • Question 6 - A 28-year-old female patient complains of a rash on her neck and forehead....

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    • A 28-year-old female patient complains of a rash on her neck and forehead. She recently came back from a trip to Greece a week ago and had her hair colored two days ago. Upon examination, there is a vesicular rash around her hairline that is oozing, but her scalp is not severely affected. What is the probable diagnosis?

      Your Answer: Allergic contact dermatitis

      Explanation:

      Understanding Contact Dermatitis

      Contact dermatitis is a skin condition that can be caused by two main types of reactions. The first type is irritant contact dermatitis, which is a non-allergic reaction that occurs due to exposure to weak acids or alkalis, such as detergents. This type of dermatitis is commonly seen on the hands and is characterized by erythema, but crusting and vesicles are rare.

      The second type of contact dermatitis is allergic contact dermatitis, which is a type IV hypersensitivity reaction. This type of dermatitis is uncommon and is often seen on the head following hair dyes. It presents as an acute weeping eczema that predominantly affects the margins of the hairline rather than the hairy scalp itself. Topical treatment with a potent steroid is indicated for this type of dermatitis.

      Cement is a frequent cause of contact dermatitis. The alkaline nature of cement may cause an irritant contact dermatitis, while the dichromates in cement can also cause an allergic contact dermatitis. It is important to understand the different types of contact dermatitis and their causes to effectively manage and treat this condition.

    • This question is part of the following fields:

      • Dermatology
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  • Question 7 - A 58-year-old man who is a recent immigrant from Tanzania complains about an...

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    • A 58-year-old man who is a recent immigrant from Tanzania complains about an ulcer on his penis. This is painless and has been present for some months, but is slowly enlarging. On examination he has an ulcer at the base of his glans and an offensive exudate. He also has bilateral inguinal lymphadenopathy.
      Select the most likely diagnosis.

      Your Answer: Penile cancer

      Explanation:

      Penile Cancer, Chancroid, and Syphilis: A Comparison

      Penile cancer is a rare condition in the UK, but is more commonly seen in patients from Asia and Africa. It is often associated with poor hygiene and herpes infections, and can cause difficulty in retracting the foreskin. The 5-year survival rate with lymph-node involvement is around 50%.

      Chancroid, on the other hand, is characterized by a painful ulcer. Lymphadenitis is also painful, and may progress to a suppurative bubo. Multiple ulcers may be present.

      In syphilis, the primary chancre typically heals within 4-8 weeks, with or without treatment.

      While these conditions may have some similarities, they are distinct and require different approaches to diagnosis and treatment. It is important to seek medical attention if you suspect you may have any of these conditions.

    • This question is part of the following fields:

      • Dermatology
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  • Question 8 - A 68-year-old male presents with a non-healing ulcer at the site of a...

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    • A 68-year-old male presents with a non-healing ulcer at the site of a flame burn injury on his foot 7 years ago. The burn injury was managed with dressings and skin grafting but has never healed completely. Over the last 4 months, he has suffered from recurrent bleeding and ulceration at this site.

      Upon examination, there is extensive scarring on the dorsal aspect of his foot, and there is a 35mm ulcerated area with associated tenderness.

      The histopathology report confirmed the presence of malignant disease, describing the presence of keratin pearls. Imaging showed evidence of metastases.

      What is the most likely type of malignancy in this case?

      Your Answer: Squamous cell carcinoma (SCC)

      Explanation:

      Understanding Squamous Cell Carcinoma of the Skin

      Squamous cell carcinoma is a type of skin cancer that is commonly seen in individuals who have had excessive exposure to sunlight or have undergone psoralen UVA therapy. Other risk factors include actinic keratoses and Bowen’s disease, immunosuppression, smoking, long-standing leg ulcers, and genetic conditions. While metastases are rare, they may occur in 2-5% of patients.

      This type of cancer typically appears on sun-exposed areas such as the head and neck or dorsum of the hands and arms. The nodules are painless, rapidly expanding, and may have a cauliflower-like appearance. Bleeding may also occur in some cases.

      Treatment for squamous cell carcinoma involves surgical excision with margins of 4mm for lesions less than 20 mm in diameter and 6mm for larger tumors. Mohs micrographic surgery may be used in high-risk patients and in cosmetically important sites. Prognosis is generally good for well-differentiated tumors that are less than 20 mm in diameter and less than 2 mm deep. However, poorly differentiated tumors that are larger than 20 mm in diameter and deeper than 4mm, as well as those associated with immunosuppression, have a poorer prognosis.

    • This question is part of the following fields:

      • Dermatology
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  • Question 9 - Which one of the following aspects of daily living is specifically inquired about...

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    • Which one of the following aspects of daily living is specifically inquired about in Dermatology Life Quality Index (DLQI)?

      Your Answer: Sexual intercourse

      Explanation:

      Understanding the Dermatology Life Quality Index (DLQI)

      The Dermatology Life Quality Index (DLQI) is a commonly used tool to evaluate the impact of chronic skin conditions on a patient’s quality of life. It consists of 10 questions, each scored out of 3, with a maximum score of 30. The higher the score, the more significant the impact on the patient’s quality of life. The DLQI covers six areas, including symptoms and feelings, daily activities, leisure, work and school, personal relationships, and treatment.

      The DLQI questions are designed to assess the level of discomfort, embarrassment, and interference with daily activities caused by the skin condition. Patients are asked to rate the severity of symptoms such as itchiness, soreness, and pain, as well as the impact on social and leisure activities, work or study, and personal relationships. The DLQI also evaluates the impact of treatment on the patient’s life.

      Interpreting the DLQI scores is straightforward. A score of 0-1 indicates no effect on the patient’s life, while a score of 2-5 suggests a small impact. A score of 6-10 indicates a moderate effect, while a score of 11-20 suggests a very large impact. A score of 21-30 indicates an extremely large impact on the patient’s life.

      In summary, the DLQI is a quick and easy tool to assess the impact of chronic skin conditions on a patient’s quality of life. It provides valuable information to healthcare professionals to tailor treatment plans and improve patient outcomes.

    • This question is part of the following fields:

      • Dermatology
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  • Question 10 - A 28-year-old woman presents with a facial rash that has been present for...

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    • A 28-year-old woman presents with a facial rash that has been present for a few weeks. The rash appears erythematous, greasy, and has a fine scale on her cheeks, nasolabial folds, eyebrows, nasal bridge, and scalp. What is the probable diagnosis?

      Your Answer: Seborrhoeic dermatitis

      Explanation:

      Seborrhoeic dermatitis is often the culprit behind an itchy rash that appears on the face and scalp. This condition is characterized by its distribution pattern, which affects these areas. It can be distinguished from acne rosacea, which typically doesn’t involve the nasolabial folds and is marked by the presence of telangiectasia and pustules.

      Understanding Seborrhoeic Dermatitis in Adults

      Seborrhoeic dermatitis is a chronic skin condition that affects around 2% of the general population. It is caused by an inflammatory reaction related to the overgrowth of a fungus called Malassezia furfur, which is a normal inhabitant of the skin. The condition is characterized by eczematous lesions that appear on the sebum-rich areas of the body, such as the scalp, periorbital, auricular, and nasolabial folds. It can also lead to the development of otitis externa and blepharitis.

      Seborrhoeic dermatitis is often associated with other medical conditions, such as HIV and Parkinson’s disease. The management of scalp disease typically involves the use of over-the-counter preparations containing zinc pyrithione or tar as a first-line treatment. If these are not effective, ketoconazole is the preferred second-line agent. Selenium sulphide and topical corticosteroids may also be useful.

      For the management of seborrhoeic dermatitis on the face and body, topical antifungals such as ketoconazole are recommended. Topical steroids can also be used, but only for short periods. However, the condition can be difficult to treat, and recurrences are common. It is important to seek medical advice if the symptoms persist or worsen despite treatment.

    • This question is part of the following fields:

      • Dermatology
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