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Question 1
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A 21-year-old man experiences sudden right-sided chest pain while exercising. The pain persists in the Emergency Department, but he is not short of breath. There is no past medical history of note. Observations are recorded:
temperature 36.6 °C
heart rate (HR) 90 bpm
blood pressure (BP) 115/80 mmHg
respiratory rate (RR) 18 breaths/minute
oxygen saturation (SaO2) 99%.
A chest X-ray reveals a 1.5 cm sliver of air in the pleural space of the right lung.
Which of the following is the most appropriate course of action?Your Answer: Consider prescribing analgesia and discharge home with information and advice
Explanation:Management Options for Primary Pneumothorax
Primary pneumothorax is a condition where air accumulates in the pleural space, causing the lung to collapse. The management of primary pneumothorax depends on the severity of the condition and the presence of symptoms. Here are some management options for primary pneumothorax:
Prescribe analgesia and discharge home with information and advice: This option can be considered if the patient is not breathless and has only a small defect. The patient can be discharged with pain relief medication and given information and advice on how to manage the condition at home.
Admit for a trial of nebulised salbutamol and observation: This option is not indicated for a patient with primary pneumothorax, as a trial of salbutamol is not effective in treating this condition.
Aspirate the air with a needle and syringe: This option should only be attempted if the patient has a rim of air of >2 cm on the chest X-ray or is breathless. Aspiration can be attempted twice at a maximum, after which a chest drain should be inserted.
Insert a chest drain: This option should be done if the second attempt of aspiration is unsuccessful. Once air has stopped leaking, the drain should be left in for a further 24 hours prior to removal and discharge.
Insert a 16G cannula into the second intercostal space: This option is used for tension pneumothoraces and is not indicated for primary pneumothorax.
In conclusion, the management of primary pneumothorax depends on the severity of the condition and the presence of symptoms. It is important to choose the appropriate management option to ensure the best outcome for the patient.
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This question is part of the following fields:
- Respiratory
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Question 2
Correct
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A 70-year-old woman comes to the clinic with left upper-lobe cavitating consolidation and sputum samples confirm the presence of Mycobacterium tuberculosis, which is fully sensitive. There is no prior history of TB treatment. What is the most suitable antibiotic regimen?
Your Answer: Rifampicin/isoniazid/pyrazinamide/ethambutol for two months, then rifampicin/isoniazid for four months
Explanation:Proper Treatment for Tuberculosis
Proper treatment for tuberculosis (TB) depends on certain sensitivities. Until these sensitivities are known, empirical treatment for TB should include four drugs: rifampicin, isoniazid, pyrazinamide, and ethambutol. Treatment can be stepped down to two drugs after two months if the organism is fully sensitive. The duration of therapy for pulmonary TB is six months.
If the sensitivities are still unknown, treatment with only three drugs, such as rifampicin, isoniazid, and pyrazinamide, is insufficient for the successful treatment of TB. Initial antibiotic treatment should be rifampicin, isoniazid, pyrazinamide, and ethambutol for two months, then rifampicin and isoniazid for four months.
However, if the patient is sensitive to rifampicin and clarithromycin, treatment for TB can be rifampicin and clarithromycin for six months. It is important to note that treatment for 12 months is too long and may not be necessary for successful treatment of TB.
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This question is part of the following fields:
- Respiratory
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Question 3
Incorrect
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A 50-year-old woman presents to her General Practitioner with increasing shortness of breath. She has also suffered from dull right iliac fossa pain over the past few months. Past history of note includes tuberculosis at the age of 23 and rheumatoid arthritis. On examination, her right chest is dull to percussion, consistent with a pleural effusion, and her abdomen appears swollen with a positive fluid thrill test. She may have a right adnexal mass.
Investigations:
Investigation
Result
Normal value
Chest X-ray Large right-sided pleural effusion
Haemoglobin 115 g/l 115–155 g/l
White cell count (WCC) 6.8 × 109/l 4–11 × 109/l
Platelets 335 × 109/l 150–400 × 109/l
Sodium (Na+) 140 mmol/l 135–145 mmol/l
Potassium (K+) 5.4 mmol/l 3.5–5.0 mmol/l
Creatinine 175 μmol/l 50–120 µmol/l
Bilirubin 28 μmol/l 2–17 µmol/l
Alanine aminotransferase 25 IU/l 5–30 IU/l
Albumin 40 g/l 35–55 g/l
CA-125 250 u/ml 0–35 u/ml
Pleural aspirate: occasional normal pleural cells, no white cells, protein 24 g/l.
Which of the following is the most likely diagnosis?Your Answer: Ovarian carcinoma with lung secondaries
Correct Answer: Meig’s syndrome
Explanation:Possible Causes of Pleural Effusion: Meig’s Syndrome, Ovarian Carcinoma, Reactivation of Tuberculosis, Rheumatoid Arthritis, and Cardiac Failure
Pleural effusion is a condition where fluid accumulates in the pleural space, the area between the lungs and the chest wall. There are various possible causes of pleural effusion, including Meig’s syndrome, ovarian carcinoma, reactivation of tuberculosis, rheumatoid arthritis, and cardiac failure.
Meig’s syndrome is characterized by the association of a benign ovarian tumor and a transudate pleural effusion. The pleural effusion resolves when the tumor is removed, although a raised CA-125 is commonly found.
Ovarian carcinoma with lung secondaries is another possible cause of pleural effusion. However, if no malignant cells are found on thoracocentesis, this diagnosis becomes less likely.
Reactivation of tuberculosis may also lead to pleural effusion, but this would be accompanied by other symptoms such as weight loss, night sweats, and fever.
Rheumatoid arthritis can produce an exudative pleural effusion, but this presentation is different from the transudate seen in Meig’s syndrome. In addition, white cells would be present due to the inflammatory response.
Finally, cardiac failure can result in bilateral pleural effusions.
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This question is part of the following fields:
- Respiratory
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Question 4
Correct
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A 56-year-old woman presents to the Emergency Department with a 2-week history of productive cough with green sputum and a one day history of palpitations. She also had some rigors and fever. On examination:
Result Normal
Respiratory rate (RR) 26 breaths/min 12–18 breaths/min
Sats 96% on air 94–98%
Blood pressure (BP) 92/48 mmHg <120/80 mmHg
Heart rate (HR) 130 bpm 60–100 beats/min
Some bronchial breathing at left lung base, heart sounds normal however with an irregularly irregular pulse. electrocardiogram (ECG) showed fast atrial fibrillation (AF). She was previously fit and well.
Which of the following is the most appropriate initial management?Your Answer: Intravenous fluids
Explanation:Treatment for AF in a Patient with Sepsis
In a patient with sepsis secondary to pneumonia, the new onset of AF is likely due to the sepsis. Therefore, the priority is to urgently treat the sepsis with intravenous fluids and broad-spectrum antibiotics. If the AF persists after the sepsis is treated, other options for AF treatment can be considered. Bisoprolol and digoxin are not the first-line treatments for AF in this case. Oral antibiotics are not recommended for septic patients. Flecainide may be considered if the AF persists after the sepsis is treated.
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This question is part of the following fields:
- Respiratory
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Question 5
Correct
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After reviewing a patient with chronic obstructive pulmonary disease (COPD) in clinic, the respiratory consultant discusses the anatomy of the lungs with a group of undergraduate students.
With regard to the lungs, which one of the following statements is accurate?Your Answer: The lungs receive a dual blood supply
Explanation:Facts about the Anatomy of the Lungs
The lungs are a vital organ responsible for respiration. Here are some important facts about their anatomy:
– The lungs receive a dual blood supply from the pulmonary artery and the bronchial arteries. A pulmonary embolus may only result in infarction when the circulation is already inadequate.
– The left lung has two lobes, while the right lung has three. The horizontal fissure is present only in the right lung.
– Each lung has ten bronchopulmonary segments, which can be selectively removed surgically if diseased.
– The right bronchus is shorter, wider, and more vertical than the left bronchus, making it more likely for foreign bodies to enter it. Aspiration pneumonia and abscess formation are common in the apical segment of the right lower lobe.Important Facts about the Anatomy of the Lungs
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This question is part of the following fields:
- Respiratory
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Question 6
Incorrect
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A 65-year-old man complains of worsening shortness of breath. During examination, the left base has a stony dull percussion note. A chest x-ray reveals opacification in the lower lobe of the left lung. What is the most suitable test for this patient?
Your Answer: CT thorax
Correct Answer: Ultrasound-guided pleural fluid aspiration
Explanation:Left Pleural Effusion Diagnosis
A left pleural effusion is present in this patient, which is likely to be significant in size. To diagnose this condition, a diagnostic aspiration is necessary. The fluid obtained from the aspiration should be sent for microscopy, culture, and cytology to determine the underlying cause of the effusion. Proper diagnosis is crucial in determining the appropriate treatment plan for the patient. Therefore, it is essential to perform a diagnostic aspiration and analyze the fluid obtained to provide the best possible care for the patient.
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This question is part of the following fields:
- Respiratory
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Question 7
Incorrect
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A 49-year-old farmer presented with progressive dyspnoea. He had a dry cough and exercise intolerance. On examination, few crackles were found in the upper zones of both lungs. Surgical lung biopsy was done which was reported as:
Interstitial inflammation, chronic bronchiolitis, and two foci of non-necrotizing granuloma.
What is the most likely clinical diagnosis?Your Answer: Sarcoidosis
Correct Answer: Hypersensitivity pneumonitis
Explanation:Differentiating Lung Disorders: Histological Features
Hypersensitivity Pneumonitis: This lung disorder is caused by a hypersensitivity reaction to mouldy hay or other organic materials. A farmer is likely to develop this condition due to exposure to such materials. The histological triad of hypersensitivity pneumonitis includes lymphocytic alveolitis, non-caseating granulomas, and poorly formed granulomas.
Aspergillosis: This lung disorder is rarely invasive. In cases where it is invasive, lung biopsy shows hyphae with vascular invasion and surrounding tissue necrosis.
Sarcoidosis: This lung disorder of unknown aetiology presents with non-caseating granuloma. Schumann bodies, which are calcified, rounded, laminated concretions inside the non-caseating granuloma, are found in sarcoidosis. The granulomas are formed of foreign body giant cells. Within the giant cells, there are star-shaped inclusions called asteroid bodies.
Histiocytosis X: This lung disorder presents with scattered nodules of Langerhans cells. Associated with it are eosinophils, macrophages, and giant cells. The Langerhans cells contain racket-shaped Birbeck granules.
Tuberculosis: This lung disorder typically has caseating granulomas in the lung parenchyma. There is also fibrosis in later stages. Ziehl–Neelsen staining of the smear reveals acid-fast bacilli (AFB) in many cases. Vasculitic lesions can also be found.
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This question is part of the following fields:
- Respiratory
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Question 8
Incorrect
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A 45-year-old woman presents with sudden-onset shortness of breath and pleuritic chest pain. After workup, including blood tests, an electrocardiogram (ECG) and a chest X-ray, a diagnosis of pulmonary embolism (PE) is suspected.
In which situation might a ventilation/perfusion (V/Q) scan be preferred to a computerised tomography pulmonary angiogram (CTPA) to confirm a diagnosis of PE?Your Answer: Weekend admission
Correct Answer: Renal impairment
Explanation:Choosing the Right Imaging Test for Suspected Pulmonary Embolism: Considerations and Limitations
When evaluating a patient with suspected pulmonary embolism (PE), choosing the appropriate imaging test can be challenging. Several factors need to be considered, including the patient’s medical history, clinical presentation, and available resources. Here are some examples of how different patient characteristics can influence the choice of imaging test:
Renal impairment: A V/Q scan may be preferred over a CTPA in patients with renal impairment, as the latter uses radiocontrast that can be nephrotoxic.
Abnormal chest X-ray: If the chest X-ray is abnormal, a V/Q scan may not be the best option, as it can be difficult to interpret. A CTPA would be more appropriate in this case.
Wells PE score of 3: The Wells score alone does not dictate the choice of imaging test. A D-dimer blood test should be obtained first, and if positive, a CTPA or V/Q scan may be necessary.
Weekend admission: Availability of imaging tests may be limited during weekends. A CTPA scan may be more feasible than a V/Q scan, as the latter requires nuclear medicine facilities that may not be available out of hours.
History of COPD: In patients with lung abnormalities such as severe COPD, a V/Q scan may be challenging to interpret. A CTPA would be a better option in this case.
In summary, choosing the right imaging test for suspected PE requires careful consideration of the patient’s characteristics and available resources. Consultation with a radiologist may be necessary in some cases.
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This question is part of the following fields:
- Respiratory
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Question 9
Incorrect
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A 65-year-old man presents with haemoptysis over the last 2 days. He has had a productive cough for 7 years, which has gradually worsened. Over the last few winters, he has been particularly bad and required admission to hospital. Past medical history includes pulmonary tuberculosis (TB) at age 20. On examination, he is cyanotic and clubbed, and has florid crepitations in both lower zones.
What is the most likely diagnosis?Your Answer: Lung cancer
Correct Answer: Bronchiectasis
Explanation:Diagnosing Respiratory Conditions: Bronchiectasis vs. Asthma vs. Pulmonary Fibrosis vs. COPD vs. Lung Cancer
Bronchiectasis is the most probable diagnosis for a patient who presents with copious sputum production, recurrent chest infections, haemoptysis, clubbing, cyanosis, and florid crepitations at both bases that change with coughing. This condition is often exacerbated by a previous history of tuberculosis.
Asthma, on the other hand, is characterized by reversible obstruction of airways due to bronchial muscle contraction in response to various stimuli. The absence of wheezing, the patient’s age, and the presence of haemoptysis make asthma an unlikely diagnosis in this case.
Pulmonary fibrosis involves parenchymal fibrosis and interstitial remodelling, leading to shortness of breath and a non-productive cough. Patients with pulmonary fibrosis may develop clubbing, basal crepitations, and a dry cough, but the acute presentation and haemoptysis in this case would not be explained.
Chronic obstructive pulmonary disease (COPD) is a progressive disorder characterized by airway obstruction, chronic bronchitis, and emphysema. However, the absence of wheezing, smoking history, and acute new haemoptysis make COPD a less likely diagnosis.
Lung cancer is a possibility given the haemoptysis and clubbing, but the long history of productive cough, florid crepitations, and previous history of TB make bronchiectasis a more likely diagnosis. Overall, a thorough evaluation of symptoms and medical history is necessary to accurately diagnose respiratory conditions.
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This question is part of the following fields:
- Respiratory
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Question 10
Correct
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A previously fit 36-year-old man presents to his general practitioner (GP) with a 4-day history of shortness of breath, a productive cough and flu-like symptoms. There is no past medical history of note. He is a non-smoker and exercises regularly. On examination, he appears unwell. There is reduced chest expansion on the left-hand side of the chest and a dull percussion note over the lower lobe of the left lung. The GP suspects a lobar pneumonia.
Which organism is likely to be responsible for this patient’s symptoms?Your Answer: Streptococcus pneumoniae
Explanation:Common Causes of Community-Acquired Pneumonia
Community-acquired pneumonia (CAP) is a lower respiratory tract infection that can be acquired outside of a hospital setting. The most common cause of CAP is Streptococcus pneumoniae, which can result in lobar or bronchopneumonia. Mycoplasma pneumoniae is another cause of CAP, often presenting with flu-like symptoms and a dry cough. Haemophilus influenzae can also cause CAP, as well as other infections such as otitis media and acute epiglottitis. Legionella pneumophila can cause outbreaks of Legionnaires disease and present with flu-like symptoms and bibasal consolidation on a chest X-ray. While Staphylococcus aureus is not a common cause of respiratory infections, it can cause severe pneumonia following influenzae or in certain populations such as the young, elderly, or intravenous drug users. Proper classification of the type of pneumonia can help predict the responsible organism and guide treatment.
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This question is part of the following fields:
- Respiratory
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