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  • Question 1 - A 16-year-old girl comes to the clinic complaining of painful periods. She has...

    Correct

    • A 16-year-old girl comes to the clinic complaining of painful periods. She has been experiencing this for the past two years and reports a normal amount of blood loss. Her periods are regular and there is no abnormal bleeding. She is not sexually active yet. What is the recommended initial treatment?

      Your Answer: Ibuprofen

      Explanation:

      First-line treatment for dysmenorrhoea involves NSAIDs, which work by inhibiting the synthesis of prostaglandins, a major contributor to menstrual pain.

      Dysmenorrhoea is a condition where women experience excessive pain during their menstrual period. There are two types of dysmenorrhoea: primary and secondary. Primary dysmenorrhoea affects up to 50% of menstruating women and is not caused by any underlying pelvic pathology. It usually appears within 1-2 years of the menarche and is thought to be partially caused by excessive endometrial prostaglandin production. Symptoms include suprapubic cramping pains that may radiate to the back or down the thigh, and pain typically starts just before or within a few hours of the period starting. NSAIDs such as mefenamic acid and ibuprofen are effective in up to 80% of women, and combined oral contraceptive pills are used second line for management.

      Secondary dysmenorrhoea, on the other hand, typically develops many years after the menarche and is caused by an underlying pathology. The pain usually starts 3-4 days before the onset of the period. Causes of secondary dysmenorrhoea include endometriosis, adenomyosis, pelvic inflammatory disease, intrauterine devices, and fibroids. Clinical Knowledge Summaries recommend referring all patients with secondary dysmenorrhoea to gynaecology for investigation. It is important to note that the intrauterine system (Mirena) may help dysmenorrhoea, but this only applies to normal copper coils.

    • This question is part of the following fields:

      • Reproductive Medicine
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  • Question 2 - A nurse updates you on a 29-year-old woman who is 24 weeks pregnant....

    Correct

    • A nurse updates you on a 29-year-old woman who is 24 weeks pregnant. The nurse reports that her blood pressure reading is 155/90 mmHg, which has increased from her previous reading of 152/85 mmHg taken 2 days ago. The woman had no health issues before her pregnancy. What is the initial course of action in this scenario?

      Your Answer: Oral labetalol

      Explanation:

      Oral labetalol is the recommended initial treatment for this woman with moderate gestational hypertension, as per the current guidelines.

      Hypertension during pregnancy is a common occurrence that requires careful management. In normal pregnancies, blood pressure tends to decrease in the first trimester and then gradually increase to pre-pregnancy levels by term. However, in cases of hypertension during pregnancy, the systolic blood pressure is usually above 140 mmHg or the diastolic blood pressure is above 90 mmHg. Additionally, an increase of more than 30 mmHg systolic or 15 mmHg diastolic from the initial readings may also indicate hypertension.

      There are three categories of hypertension during pregnancy: pre-existing hypertension, pregnancy-induced hypertension (PIH), and pre-eclampsia. Pre-existing hypertension refers to a history of hypertension before pregnancy or elevated blood pressure before 20 weeks gestation. PIH occurs in the second half of pregnancy and resolves after birth. Pre-eclampsia is characterized by hypertension and proteinuria, and may also involve edema.

      The management of hypertension during pregnancy involves the use of antihypertensive medications such as labetalol, nifedipine, and hydralazine. In cases of pre-existing hypertension, ACE inhibitors and angiotensin II receptor blockers should be stopped immediately and alternative medications should be prescribed. Women who are at high risk of developing pre-eclampsia should take aspirin from 12 weeks until the birth of the baby. It is important to carefully monitor blood pressure and proteinuria levels during pregnancy to ensure the health of both the mother and the baby.

    • This question is part of the following fields:

      • Reproductive Medicine
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  • Question 3 - You assess a 27-year-old woman who presents with vaginal bleeding and lower abdominal...

    Correct

    • You assess a 27-year-old woman who presents with vaginal bleeding and lower abdominal pain. She had an IUD inserted as emergency contraception two weeks ago after having unprotected intercourse 6 days prior. The pain is described as severe dysmenorrhoea and is more pronounced in the right iliac fossa. She has been experiencing continuous bleeding for the past 6 days, whereas her normal menstrual cycle lasts 28 days with 4 days of bleeding. She has no issues with eating or drinking. On examination, her temperature is 36.5ºC, and her blood pressure is 104/68 mmHg. There is mild tenderness in the right iliac fossa with no guarding. Urine dip shows no abnormalities, and urine hCG is negative. What is the most probable diagnosis?

      Your Answer: Side-effects of IUD

      Explanation:

      The woman’s symptoms are most likely caused by the intrauterine device (IUD), which is known to increase the intensity and discomfort of periods. Ectopic pregnancy and miscarriage are unlikely as the pregnancy test was negative. A urinary tract infection is also unlikely as the urine dip was normal. Although appendicitis should be considered, it does not explain the vaginal bleeding, and the woman’s normal appetite, lack of fever, and mild examination results do not support this diagnosis.

      Intrauterine contraceptive devices include copper IUDs and levonorgestrel-releasing IUS. Both are over 99% effective. The IUD prevents fertilization by decreasing sperm motility, while the IUS prevents endometrial proliferation and thickens cervical mucus. Potential problems include heavier periods with IUDs and initial bleeding with the IUS. There is a small risk of uterine perforation, ectopic pregnancy, and infection. New IUS systems, such as Jaydess® and Kyleena®, have smaller frames and less levonorgestrel, resulting in lower serum levels and different rates of amenorrhea.

    • This question is part of the following fields:

      • Reproductive Medicine
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  • Question 4 - A 19-year-old visits her GP the day after having unprotected sex and requests...

    Incorrect

    • A 19-year-old visits her GP the day after having unprotected sex and requests emergency contraception to prevent pregnancy. After a negative pregnancy test, what is the next best course of action for the GP to take?

      Your Answer: Combined oral contraceptive pill

      Correct Answer: Levonorgestrel

      Explanation:

      When taken correctly, the pill is an effective method of preventing pregnancy, but it cannot prevent implantation if taken after engaging in unprotected sexual intercourse.

      Emergency contraception is available in the UK through two methods: emergency hormonal contraception and intrauterine device (IUD). Emergency hormonal contraception includes two types of pills: levonorgestrel and ulipristal. Levonorgestrel works by stopping ovulation and inhibiting implantation, while ulipristal primarily inhibits ovulation. Levonorgestrel should be taken as soon as possible after unprotected sexual intercourse, within 72 hours, and is 84% effective when used within this time frame. The dose should be doubled for those with a BMI over 26 or weight over 70kg. Ulipristal should be taken within 120 hours of intercourse and may reduce the effectiveness of hormonal contraception. The most effective method of emergency contraception is the copper IUD, which can be inserted within 5 days of unprotected intercourse or up to 5 days after the likely ovulation date. It may inhibit fertilization or implantation and is 99% effective regardless of where it is used in the cycle. Prophylactic antibiotics may be given if the patient is at high risk of sexually transmitted infection.

    • This question is part of the following fields:

      • Reproductive Medicine
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  • Question 5 - A nurse updates you on a 32-year-old woman who is 38 weeks pregnant....

    Correct

    • A nurse updates you on a 32-year-old woman who is 38 weeks pregnant. The patient's blood pressure reading is 155/90 mmHg, up from 152/85 mmHg two days ago. A 24-hour urine collection shows a urinary protein excretion of 0.7g / 24 hours. The patient was previously healthy before pregnancy. Following oral labetalol administration, what is the next step in managing this situation?

      Your Answer: Plan delivery of the foetus within 48 hours

      Explanation:

      Pregnant women who have mild or moderate gestational hypertension, are beyond 37 weeks of pregnancy, and exhibit pre-eclampsia symptoms, should be advised to deliver their baby within 24 to 48 hours as per the existing recommendations.

      Hypertension during pregnancy is a common occurrence that requires careful management. In normal pregnancies, blood pressure tends to decrease in the first trimester and then gradually increase to pre-pregnancy levels by term. However, in cases of hypertension during pregnancy, the systolic blood pressure is usually above 140 mmHg or the diastolic blood pressure is above 90 mmHg. Additionally, an increase of more than 30 mmHg systolic or 15 mmHg diastolic from the initial readings may also indicate hypertension.

      There are three categories of hypertension during pregnancy: pre-existing hypertension, pregnancy-induced hypertension (PIH), and pre-eclampsia. Pre-existing hypertension refers to a history of hypertension before pregnancy or elevated blood pressure before 20 weeks gestation. PIH occurs in the second half of pregnancy and resolves after birth. Pre-eclampsia is characterized by hypertension and proteinuria, and may also involve edema.

      The management of hypertension during pregnancy involves the use of antihypertensive medications such as labetalol, nifedipine, and hydralazine. In cases of pre-existing hypertension, ACE inhibitors and angiotensin II receptor blockers should be stopped immediately and alternative medications should be prescribed. Women who are at high risk of developing pre-eclampsia should take aspirin from 12 weeks until the birth of the baby. It is important to carefully monitor blood pressure and proteinuria levels during pregnancy to ensure the health of both the mother and the baby.

    • This question is part of the following fields:

      • Reproductive Medicine
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  • Question 6 - A 35-year-old woman who is 20 weeks pregnant attends the antenatal clinic. She...

    Correct

    • A 35-year-old woman who is 20 weeks pregnant attends the antenatal clinic. She had an OGTT at her booking visit due to a family history of type II diabetes mellitus.

      The results at the 14-week booking were:
      Fasting glucose 6.2 mmol/L Normal <5.6 mmol/L
      2-hour post glucose challenge 9.5 mmol/L Normal <7.8mmol/L

      A decision is made to start metformin 500mg twice daily and she is provided with information leaflets regarding diet and lifestyle modification.

      On review today at 20 weeks gestation her repeat OGTT results are as follows:
      Fasting glucose 6.1 mmol/L Normal <5.3 mmol/L
      2-hour post glucose challenge 7.5 mmol/L Normal <6.4 mmol/L

      What is the next most appropriate action for managing her blood glucose levels?

      Your Answer: Add insulin

      Explanation:

      If blood glucose targets are not achieved through diet and metformin in gestational diabetes, insulin should be introduced.

      The patient in this case was diagnosed with gestational diabetes during their initial appointment. Despite attempting metformin, their fasting and two-hour post glucose challenge blood glucose levels remain elevated above the normal range. Therefore, insulin should be added to their treatment plan. Choosing to make no changes to their treatment plan is not the correct answer, as this could lead to increased risks for the fetus, such as the development of polyhydramnios or macrosomia. While referral for dietary and exercise regimens may be considered, this is likely to be a first-line intervention, and further escalation of medical therapy is necessary for the health of the fetus. Increasing the dose of metformin is not the correct answer, as the NICE guidelines recommend starting insulin when initial interventions have been unsuccessful. Waiting two weeks to repeat the results would delay necessary treatment intensification, which is required at the current clinic appointment.

      Gestational diabetes is a common medical disorder affecting around 4% of pregnancies. Risk factors include a high BMI, previous gestational diabetes, and family history of diabetes. Screening is done through an oral glucose tolerance test, and diagnostic thresholds have recently been updated. Management includes self-monitoring of blood glucose, diet and exercise advice, and medication if necessary. For pre-existing diabetes, weight loss and insulin are recommended, and tight glycemic control is important. Targets for self-monitoring include fasting glucose of 5.3 mmol/l and 1-2 hour post-meal glucose levels.

    • This question is part of the following fields:

      • Reproductive Medicine
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  • Question 7 - A 28-year-old female who is typically healthy presents with flu-like symptoms that have...

    Correct

    • A 28-year-old female who is typically healthy presents with flu-like symptoms that have persisted for several days. She has recently observed a rash of spots in her genital region and is experiencing discomfort and pain while urinating. What is the probable diagnosis?

      Your Answer: Herpes simplex

      Explanation:

      Understanding Herpes Simplex Virus

      Herpes simplex virus (HSV) is a common viral infection that affects humans. There are two strains of the virus, HSV-1 and HSV-2, which were previously thought to cause oral and genital herpes, respectively. However, there is now considerable overlap between the two strains. The primary infection may present with severe gingivostomatitis, while cold sores and painful genital ulceration are common features.

      Management of HSV includes oral aciclovir for gingivostomatitis and genital herpes, and topical aciclovir for cold sores, although the evidence base for the latter is modest. Patients with frequent exacerbations may benefit from longer-term aciclovir. In pregnant women, a primary attack of herpes during pregnancy at greater than 28 weeks gestation may require elective caesarean section at term. Women with recurrent herpes who are pregnant should be treated with suppressive therapy and advised that the risk of transmission to their baby is low.

      The cytopathic effect of HSV can be seen in Pap smears, which show multinucleated giant cells representing infection by the virus. The 3 M’s – multinucleation, margination of the chromatin, and molding of the nuclei – are characteristic features of HSV infection. Understanding the features and management of HSV is important for effective treatment and prevention of transmission.

    • This question is part of the following fields:

      • Reproductive Medicine
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  • Question 8 - A 14-year-old girl presents to the GP with concerns regarding menstruation, as she...

    Incorrect

    • A 14-year-old girl presents to the GP with concerns regarding menstruation, as she has not yet started her periods. She has no past medical history.

      On examination, there is little to no axillary or pubic hair, and she has a tall stature. Bilateral lower pelvic masses are noted. Her BMI is 19 kg/m².

      Investigations are performed:

      Hb 130 g/L (115 - 160)

      Platelets 200 * 109/L (150 - 400)

      WBC 5.7 * 109/L (4.0 - 11.0)

      FSH 9 IU/L (1 - 12)

      LH 7 IU/L (1 - 9)

      Testosterone 100 ng/dL (15-70)

      Estradiol 30 pg/mL (30 - 400)

      What is the most likely diagnosis?

      Your Answer: Congenital adrenal hyperplasia

      Correct Answer: Androgen insensitivity syndrome

      Explanation:

      The most likely diagnosis for this patient is androgen insensitivity syndrome (AIS). This is because she has not started menstruating by the age of 15, has little to no axillary or pubic hair, and elevated testosterone levels. These symptoms are all indicative of AIS, which is a genetic condition where individuals with male chromosomes (46XY) have a female appearance due to their body’s resistance to testosterone. The lower pelvic masses seen on examination are likely to be undescended testes.

      Congenital adrenal hyperplasia (CAH) is an unlikely diagnosis as it typically causes excess male-pattern hair growth, including axillary and pubic hair, which is not seen in this patient. Additionally, CAH would not explain the presence of the lower pelvic masses.

      Functional hypothalamic amenorrhoea is also unlikely as this condition is typically associated with low body weight, which is not the case for this patient. Furthermore, her FSH and LH levels are within the normal range, indicating that there is no hypothalamic dysfunction.

      Polycystic ovarian syndrome (PCOS) is an unlikely diagnosis as it typically causes irregular periods rather than a complete absence of menstruation. Additionally, patients with PCOS often have excessive hair growth, which is not seen in this patient. PCOS would also not explain the presence of the lower pelvic masses.

      Understanding Androgen Insensitivity Syndrome

      Androgen insensitivity syndrome is a genetic condition that affects individuals with an XY genotype, causing them to develop a female phenotype due to their body’s resistance to testosterone. This condition was previously known as testicular feminization syndrome. The main features of this condition include primary amenorrhea, little or no pubic and axillary hair, undescended testes leading to groin swellings, and breast development due to the conversion of testosterone to estrogen.

      Diagnosis of androgen insensitivity syndrome can be made through a buccal smear or chromosomal analysis, which reveals a 46XY genotype. After puberty, testosterone levels in affected individuals are typically in the high-normal to slightly elevated range for postpubertal boys.

      Management of androgen insensitivity syndrome involves counseling and raising the child as female. Bilateral orchidectomy is recommended to reduce the risk of testicular cancer due to undescended testes. Additionally, estrogen therapy may be used to promote the development of secondary sexual characteristics.

      In summary, androgen insensitivity syndrome is a genetic condition that affects the development of individuals with an XY genotype, causing them to develop a female phenotype. Early diagnosis and management can help affected individuals lead healthy and fulfilling lives.

    • This question is part of the following fields:

      • Reproductive Medicine
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  • Question 9 - A 25-year-old woman visits the GUM clinic at 18 weeks gestation. Her partner...

    Incorrect

    • A 25-year-old woman visits the GUM clinic at 18 weeks gestation. Her partner has tested positive for Chlamydia and she needs treatment as a contact. The doctor prescribes a single dose of azithromycin 1g and screens her for infection. When is it appropriate to conduct a test of cure (TOC)?

      Your Answer: 2 weeks

      Correct Answer: 6 weeks

      Explanation:

      For symptomatic men with Chlamydia, it is recommended to notify all sexual partners from the 4 weeks prior to the onset of symptoms. As for women and asymptomatic men, all sexual partners from the last 6 months or the most recent partner should be notified. Pregnant women should undergo a test of cure (TOC) 6 weeks after infection, according to BASHH guidelines. Performing a TOC earlier than 6 weeks may result in a false positive due to the presence of nonviable Chlamydia DNA on the NAAT. However, uncomplicated Chlamydia infection in men and non-pregnant women does not require a routine TOC.

      Chlamydia is a common sexually transmitted infection caused by Chlamydia trachomatis. It is prevalent in the UK, with approximately 1 in 10 young women affected. The incubation period is around 7-21 days, but many cases are asymptomatic. Symptoms in women include cervicitis, discharge, and bleeding, while men may experience urethral discharge and dysuria. Complications can include epididymitis, pelvic inflammatory disease, and infertility.

      Traditional cell culture is no longer widely used for diagnosis, with nuclear acid amplification tests (NAATs) being the preferred method. Testing can be done using urine, vulvovaginal swab, or cervical swab. Screening is recommended for sexually active individuals aged 15-24 years, and opportunistic testing is common.

      Doxycycline is the first-line treatment for Chlamydia, with azithromycin as an alternative if doxycycline is contraindicated or not tolerated. Pregnant women may be treated with azithromycin, erythromycin, or amoxicillin. Patients diagnosed with Chlamydia should be offered partner notification services, with all contacts since the onset of symptoms or within the last six months being notified and offered treatment.

    • This question is part of the following fields:

      • Reproductive Medicine
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  • Question 10 - A 20-year-old female presents to the emergency department with left-sided pelvic pain and...

    Incorrect

    • A 20-year-old female presents to the emergency department with left-sided pelvic pain and vaginal bleeding. She reports her last menstrual period was 8 weeks ago and has had a positive urinary pregnancy test. The patient is stable hemodynamically, and bloods have been taken for full blood count, renal and liver function, and C-reactive protein. What is the most suitable diagnostic test to determine the underlying cause of her symptoms?

      Your Answer: Transabdominal pelvic ultrasound scan

      Correct Answer: Transvaginal ultrasound scan

      Explanation:

      To confirm or rule out ectopic pregnancy, the recommended investigation is transvaginal ultrasound. This is because it provides clearer images of the uterus, ovaries, and endometrium, making it more effective in detecting ectopic pregnancies compared to transabdominal scans. While serum Beta-HCG levels are helpful in managing ectopic pregnancies, a single test cannot completely rule out the possibility. Pregnant women are generally advised against undergoing CT scans and abdominal X-rays.

      Ectopic pregnancy is a serious condition that requires prompt investigation and management. Women who are stable are typically investigated and managed in an early pregnancy assessment unit, while those who are unstable should be referred to the emergency department. The investigation of choice for ectopic pregnancy is a transvaginal ultrasound, which will confirm the presence of a positive pregnancy test.

      There are three ways to manage ectopic pregnancies: expectant management, medical management, and surgical management. The choice of management will depend on various criteria, such as the size of the ectopic pregnancy, whether it is ruptured or not, and the patient’s symptoms and hCG levels. Expectant management involves closely monitoring the patient over 48 hours, while medical management involves giving the patient methotrexate and requires follow-up. Surgical management can involve salpingectomy or salpingotomy, depending on the patient’s risk factors for infertility.

      Salpingectomy is the first-line treatment for women with no other risk factors for infertility, while salpingotomy should be considered for women with contralateral tube damage. However, around 1 in 5 women who undergo a salpingotomy require further treatment, such as methotrexate and/or a salpingectomy. It is important to carefully consider the patient’s individual circumstances and make a decision that will provide the best possible outcome.

    • This question is part of the following fields:

      • Reproductive Medicine
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  • Question 11 - At her booking appointment, a 29-year-old pregnant woman reports a history of pre-eclampsia...

    Correct

    • At her booking appointment, a 29-year-old pregnant woman reports a history of pre-eclampsia in her previous pregnancy. To decrease the risk of intrauterine growth retardation, what medication should be initiated at 12-14 weeks gestation?

      Your Answer: Low dose aspirin

      Explanation:

      What is the effectiveness of secondary prevention measures for women with pre-eclampsia? A-level research has shown that low-dose aspirin, when started at 12-14 weeks’ gestation, is more effective than a placebo in reducing the occurrence of pre-eclampsia in high-risk women. This treatment also reduces perinatal mortality and the risk of babies being born small for gestational age. While low molecular weight heparin may reduce placental insufficiency in pre-eclampsia, there is currently a lack of long-term safety studies. Labetalol and methyldopa are commonly used antihypertensive drugs for acute management of pre-eclampsia, but they are not given prophylactically and do not reduce intrauterine growth retardation. Unfractionated heparin has also not been proven to prevent the development of uteroplacental insufficiency.

      Hypertension during pregnancy is a common occurrence that requires careful management. In normal pregnancies, blood pressure tends to decrease in the first trimester and then gradually increase to pre-pregnancy levels by term. However, in cases of hypertension during pregnancy, the systolic blood pressure is usually above 140 mmHg or the diastolic blood pressure is above 90 mmHg. Additionally, an increase of more than 30 mmHg systolic or 15 mmHg diastolic from the initial readings may also indicate hypertension.

      There are three categories of hypertension during pregnancy: pre-existing hypertension, pregnancy-induced hypertension (PIH), and pre-eclampsia. Pre-existing hypertension refers to a history of hypertension before pregnancy or elevated blood pressure before 20 weeks gestation. PIH occurs in the second half of pregnancy and resolves after birth. Pre-eclampsia is characterized by hypertension and proteinuria, and may also involve edema.

      The management of hypertension during pregnancy involves the use of antihypertensive medications such as labetalol, nifedipine, and hydralazine. In cases of pre-existing hypertension, ACE inhibitors and angiotensin II receptor blockers should be stopped immediately and alternative medications should be prescribed. Women who are at high risk of developing pre-eclampsia should take aspirin from 12 weeks until the birth of the baby. It is important to carefully monitor blood pressure and proteinuria levels during pregnancy to ensure the health of both the mother and the baby.

    • This question is part of the following fields:

      • Reproductive Medicine
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  • Question 12 - A 38-year-old woman presents with menorrhagia and is diagnosed with a 1.5 cm...

    Correct

    • A 38-year-old woman presents with menorrhagia and is diagnosed with a 1.5 cm uterine fibroid that is not distorting the uterine cavity. She has two children and desires ongoing contraception, but is currently relying solely on condoms. What is the recommended initial treatment for her menorrhagia?

      Your Answer: Intrauterine system

      Explanation:

      Medical treatment can be attempted for uterine fibroids that are smaller than 3 cm and do not distort the uterine cavity. This may include options such as an intrauterine system, tranexamic acid, or COCP. The NICE Clinical Knowledge Summaries suggest starting with an intrauterine system, which can also serve as a form of contraception.

      Understanding Uterine Fibroids

      Uterine fibroids are non-cancerous growths that develop in the uterus. They are more common in black women and are thought to occur in around 20% of white women in their later reproductive years. Fibroids are usually asymptomatic, but they can cause menorrhagia, which can lead to iron-deficiency anaemia. Other symptoms include lower abdominal pain, bloating, and urinary symptoms. Fibroids may also cause subfertility.

      Diagnosis is usually made through transvaginal ultrasound. Asymptomatic fibroids do not require treatment, but periodic monitoring is recommended. Menorrhagia secondary to fibroids can be managed with various treatments, including the levonorgestrel intrauterine system, NSAIDs, tranexamic acid, and hormonal therapies.

      Medical treatment to shrink or remove fibroids may include GnRH agonists or ulipristal acetate, although the latter is not currently recommended due to concerns about liver toxicity. Surgical options include myomectomy, hysteroscopic endometrial ablation, hysterectomy, and uterine artery embolization.

      Fibroids generally regress after menopause, but complications such as subfertility and iron-deficiency anaemia can occur. Red degeneration, which is haemorrhage into the tumour, is a common complication during pregnancy.

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      • Reproductive Medicine
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  • Question 13 - Sophie, 16, has come to her doctor's office to ask for the combined...

    Correct

    • Sophie, 16, has come to her doctor's office to ask for the combined oral contraceptive pill (COCP). As per the guidelines of the Faculty of Sexual and Reproductive Healthcare (FSRH), what is an absolute contraindication for the COCP?

      Your Answer: Migraine with aura

      Explanation:

      The FSRH uses a scale of 1 to 4 to categorize risk factors for contraceptive methods. A rating of 1 indicates no restrictions on use, while a rating of 4 indicates a condition that poses an unacceptable risk if the contraceptive method is used. Migraine with aura is the only absolute contraindication among the answer options. Ratings of 2 and 3 indicate that the advantages and risks of the contraceptive method should be carefully considered and evaluated by a clinical expert.

      The decision to prescribe the combined oral contraceptive pill is now based on the UK Medical Eligibility Criteria (UKMEC), which categorizes potential contraindications and cautions on a four-point scale. UKMEC 1 indicates no restrictions for use, while UKMEC 2 suggests that the benefits outweigh the risks. UKMEC 3 indicates that the disadvantages may outweigh the advantages, and UKMEC 4 represents an unacceptable health risk. Examples of UKMEC 3 conditions include controlled hypertension, a family history of thromboembolic disease in first-degree relatives under 45 years old, and current gallbladder disease. Examples of UKMEC 4 conditions include a history of thromboembolic disease or thrombogenic mutation, breast cancer, and uncontrolled hypertension. Diabetes mellitus diagnosed over 20 years ago is classified as UKMEC 3 or 4 depending on severity. In 2016, breast feeding between 6 weeks and 6 months postpartum was changed from UKMEC 3 to UKMEC 2.

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      • Reproductive Medicine
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  • Question 14 - A 23-year-old woman contacts her doctor to request a referral for antenatal care....

    Incorrect

    • A 23-year-old woman contacts her doctor to request a referral for antenatal care. She has been attempting to conceive for the past year and has recently received a positive pregnancy test result. Her LMP was 5 weeks ago, which prompted her to take the test. The patient is in good health with no underlying medical conditions, does not smoke, and abstains from alcohol. Her BMI is 34 kg/m².

      What is the advised folic acid consumption for this patient?

      Your Answer: Folic acid 400mcg daily, continue until end of pregnancy

      Correct Answer: Folic acid 5mg daily, continue until end of 1st trimester

      Explanation:

      Pregnant women who have a BMI of 30 kg/m² or higher should be given a daily dose of 5mg folic acid until the 13th week of their pregnancy. Folic acid is crucial during the first trimester as it helps prevent neural tube defects (NTD). Typically, a daily dose of 400mcg is sufficient for most pregnant women during the first 12 weeks of pregnancy. However, those with a BMI of over 30 kg/m², as well as those with diabetes, sickle cell disease (SCD), thalassaemia trait, coeliac disease, on anti-epileptic medication, personal or family history of NTD, or who have previously given birth to a baby with an NTD, should be prescribed a daily dose of 5mg folic acid. It is recommended that folic acid be taken while trying to conceive to further reduce the risk of NTD. Additionally, NICE advises all pregnant women to take a daily dose of 10mcg (400 units) of vitamin D throughout their entire pregnancy.

      Pregnancy and Obesity: Risks and Management

      Obesity during pregnancy can lead to various complications for both the mother and the unborn child. A BMI of 30 kg/m² or higher at the first antenatal visit is considered obese. Maternal risks include miscarriage, venous thromboembolism, gestational diabetes, pre-eclampsia, dysfunctional and induced labour, postpartum haemorrhage, wound infections, and a higher rate of caesarean section. Fetal risks include congenital anomaly, prematurity, macrosomia, stillbirth, increased risk of developing obesity and metabolic disorders in childhood, and neonatal death.

      It is important to inform women with a BMI of 30 or more at the booking appointment about the risks associated with obesity during pregnancy. They should not attempt to reduce the risk by dieting while pregnant, and healthcare professionals will manage the risk during their pregnancy.

      Management of obesity during pregnancy includes taking 5mg of folic acid instead of 400mcg, screening for gestational diabetes with an oral glucose tolerance test (OGTT) at 24-28 weeks, giving birth in a consultant-led obstetric unit if the BMI is 35 kg/m² or higher, and having an antenatal consultation with an obstetric anaesthetist and a plan made if the BMI is 40 kg/m² or higher. It is important to manage obesity during pregnancy to reduce the risks and ensure the health of both the mother and the unborn child.

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      • Reproductive Medicine
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  • Question 15 - A 30-year-old woman visits her GP with a query regarding oral contraception. She...

    Incorrect

    • A 30-year-old woman visits her GP with a query regarding oral contraception. She gave birth to her fourth child 2 weeks ago and believes that her family is complete. After weighing the options, she has decided to begin taking the combined contraceptive pill. She has no significant medical history and only takes regular vitamin supplements without any allergies. She is not breastfeeding at the moment.
      What is the earliest possible time for her to start taking her preferred contraceptive?

      Your Answer: Commence 1 week post-partum

      Correct Answer: Commence 3 weeks post-partum

      Explanation:

      Women need to start using contraception only 21 days after giving birth during the post-partum period. It is recommended that they begin taking the combined contraceptive pill three weeks after delivery. However, if they are breastfeeding, they should wait for six weeks before starting the pill.

      After giving birth, women need to use contraception after 21 days. The progestogen-only pill (POP) can be started at any time postpartum, according to the FSRH. Additional contraception should be used for the first two days after day 21. A small amount of progestogen enters breast milk, but it is not harmful to the infant. On the other hand, the combined oral contraceptive pill (COCP) is absolutely contraindicated (UKMEC 4) if breastfeeding is less than six weeks post-partum. If breastfeeding is between six weeks and six months postpartum, it is a UKMEC 2. The COCP may reduce breast milk production in lactating mothers. It should not be used in the first 21 days due to the increased venous thromboembolism risk post-partum. After day 21, additional contraception should be used for the first seven days. The intrauterine device or intrauterine system can be inserted within 48 hours of childbirth or after four weeks.

      The lactational amenorrhoea method (LAM) is 98% effective if the woman is fully breastfeeding (no supplementary feeds), amenorrhoeic, and less than six months post-partum. It is important to note that an inter-pregnancy interval of less than 12 months between childbirth and conceiving again is associated with an increased risk of preterm birth, low birth weight, and small for gestational age babies.

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  • Question 16 - A 21-year-old female presents for a follow-up after a medical termination of pregnancy...

    Correct

    • A 21-year-old female presents for a follow-up after a medical termination of pregnancy at 8 weeks gestation. She is considering getting a Nexplanon implant. When is it appropriate to insert Nexplanon in this situation?

      Your Answer: Immediately

      Explanation:

      Implanon and Nexplanon are subdermal contraceptive implants that slowly release the progestogen hormone etonogestrel to prevent ovulation and thicken cervical mucus. Nexplanon is the newer version and has a redesigned applicator to prevent deep insertions and is radiopaque for easier location. It is highly effective with a failure rate of 0.07/100 women-years and lasts for 3 years. It does not contain estrogen, making it suitable for women with a past history of thromboembolism or migraine. It can be inserted immediately after a termination of pregnancy. However, a trained professional is needed for insertion and removal, and additional contraceptive methods are required for the first 7 days if not inserted on days 1 to 5 of a woman’s menstrual cycle.

      The main disadvantage of these implants is irregular and heavy bleeding, which can be managed with a co-prescription of the combined oral contraceptive pill. Other adverse effects include headache, nausea, and breast pain. Enzyme-inducing drugs such as certain antiepileptic and rifampicin may reduce the efficacy of Nexplanon, and women should switch to a method unaffected by enzyme-inducing drugs or use additional contraception until 28 days after stopping the treatment.

      There are also contraindications for using these implants, such as ischaemic heart disease/stroke, unexplained, suspicious vaginal bleeding, past breast cancer, severe liver cirrhosis, and liver cancer. Current breast cancer is a UKMEC 4 condition, which represents an unacceptable risk if the contraceptive method is used. Overall, these implants are a highly effective and long-acting form of contraception, but they require careful consideration of the potential risks and contraindications.

    • This question is part of the following fields:

      • Reproductive Medicine
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  • Question 17 - A 27 year old woman with a confirmed diagnosis of premenstrual syndrome (PMS)...

    Correct

    • A 27 year old woman with a confirmed diagnosis of premenstrual syndrome (PMS) visits her GP seeking medical intervention. Despite implementing recommended lifestyle changes, she has seen minimal relief in her symptoms. She has no immediate plans of starting a family. What treatment option would be appropriate to suggest, provided there are no contraindications?

      Your Answer: Combined oral contraceptive pill

      Explanation:

      Understanding Premenstrual Syndrome (PMS)

      Premenstrual syndrome (PMS) is a condition that affects women during the luteal phase of their menstrual cycle. It is characterized by emotional and physical symptoms that can range from mild to severe. PMS only occurs in women who have ovulatory menstrual cycles and does not occur before puberty, during pregnancy, or after menopause.

      Emotional symptoms of PMS include anxiety, stress, fatigue, and mood swings. Physical symptoms may include bloating and breast pain. The severity of symptoms varies from woman to woman, and management options depend on the severity of symptoms.

      Mild symptoms can be managed with lifestyle advice, such as getting enough sleep, exercising regularly, and avoiding smoking and alcohol. Specific advice includes eating regular, frequent, small, balanced meals that are rich in complex carbohydrates.

      Moderate symptoms may benefit from a new-generation combined oral contraceptive pill (COCP), such as Yasmin® (drospirenone 3 mg and ethinylestradiol 0.030 mg). Severe symptoms may benefit from a selective serotonin reuptake inhibitor (SSRI), which can be taken continuously or just during the luteal phase of the menstrual cycle (for example, days 15-28, depending on the length of the cycle). Understanding PMS and its management options can help women better cope with this common condition.

    • This question is part of the following fields:

      • Reproductive Medicine
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  • Question 18 - A 27-year-old woman who has never given birth presents to your clinic seeking...

    Incorrect

    • A 27-year-old woman who has never given birth presents to your clinic seeking contraception. She complains of experiencing extremely heavy menstrual periods and desires a long-term contraceptive option that can alleviate her heavy bleeding. What is the most appropriate contraceptive method for this patient?

      Your Answer: Copper coil

      Correct Answer: Intrauterine system

      Explanation:

      The Mirena coil is a contraceptive method that reduces the duration and intensity of periods and can be used for an extended period.

      Intrauterine contraceptive devices include copper IUDs and levonorgestrel-releasing IUS. Both are over 99% effective. The IUD prevents fertilization by decreasing sperm motility, while the IUS prevents endometrial proliferation and thickens cervical mucus. Potential problems include heavier periods with IUDs and initial bleeding with the IUS. There is a small risk of uterine perforation, ectopic pregnancy, and infection. New IUS systems, such as Jaydess® and Kyleena®, have smaller frames and less levonorgestrel, resulting in lower serum levels and different rates of amenorrhea.

    • This question is part of the following fields:

      • Reproductive Medicine
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  • Question 19 - Which one of the following statements regarding endometrial cancer is false? ...

    Incorrect

    • Which one of the following statements regarding endometrial cancer is false?

      Your Answer: Treatment of early disease is with total abdominal hysterectomy with bilateral salpingo-oophorectomy

      Correct Answer: Has a poor prognosis

      Explanation:

      The prognosis for endometrial cancer is generally favorable.

      Endometrial cancer is a type of cancer that is commonly found in women who have gone through menopause, but it can also occur in around 25% of cases before menopause. The prognosis for this type of cancer is usually good due to early detection. There are several risk factors associated with endometrial cancer, including obesity, nulliparity, early menarche, late menopause, unopposed estrogen, diabetes mellitus, tamoxifen, polycystic ovarian syndrome, and hereditary non-polyposis colorectal carcinoma. Postmenopausal bleeding is the most common symptom of endometrial cancer, which is usually slight and intermittent initially before becoming more heavy. Pain is not common and typically signifies extensive disease, while vaginal discharge is unusual.

      When investigating endometrial cancer, women who are 55 years or older and present with postmenopausal bleeding should be referred using the suspected cancer pathway. The first-line investigation is trans-vaginal ultrasound, which has a high negative predictive value for a normal endometrial thickness (< 4 mm). Hysteroscopy with endometrial biopsy is also commonly used for investigation. The management of localized disease involves total abdominal hysterectomy with bilateral salpingo-oophorectomy, while patients with high-risk disease may have postoperative radiotherapy. Progestogen therapy is sometimes used in frail elderly women who are not considered suitable for surgery. It is important to note that the combined oral contraceptive pill and smoking are protective against endometrial cancer.

    • This question is part of the following fields:

      • Reproductive Medicine
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  • Question 20 - What is the most frequent negative outcome encountered by females who consume the...

    Correct

    • What is the most frequent negative outcome encountered by females who consume the progestin-only pill?

      Your Answer: Irregular vaginal bleeding

      Explanation:

      Pros and Cons of the Progestogen Only Pill

      The progestogen only pill, also known as the mini-pill, is a highly effective form of contraception with a failure rate of only 1 per 100 woman years. One of its advantages is that it does not interfere with sex and its contraceptive effects are reversible upon stopping. It can also be used while breastfeeding and in situations where the combined oral contraceptive pill is contraindicated, such as in smokers over 35 years of age and women with a history of venous thromboembolic disease.

      However, the progestogen only pill also has its disadvantages. One of the most common adverse effects is irregular periods, with some users not having periods while others may experience irregular or light periods. It also does not protect against sexually transmitted infections and has an increased incidence of functional ovarian cysts. Common side-effects include breast tenderness, weight gain, acne, and headaches, although these symptoms generally subside after the first few months. Despite its drawbacks, the progestogen only pill remains a popular choice for women seeking a reliable and convenient form of contraception.

    • This question is part of the following fields:

      • Reproductive Medicine
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