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Question 1
Correct
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You are a doctor in the emergency department. A 33-year-old man comes in with weakness in his hand. He was playing basketball with his friends and fell on his hand an hour ago. During the examination, it is observed that the patient cannot extend his forearm, wrist, and fingers, and there is unopposed flexion of the wrist.
Which nerve is most likely affected?Your Answer: Radial
Explanation:A patient with a humeral midshaft fracture is experiencing wrist drop, which is indicative of radial nerve injury. This is characterized by the inability to extend the forearm, wrist, and fingers, and unopposed flexion of the wrist. It is important to note that injury to the axillary nerve results in flattened deltoid, while median nerve injury can cause paralysis of the thenar muscles or loss of pronation of the forearm and weak wrist flexion. Musculocutaneous nerve injury primarily affects elbow flexion and supination and is unlikely to affect the movements of the forearm, wrist, and fingers. Ulnar nerve injury, on the other hand, leads to a claw hand rather than wrist drop.
Upper limb anatomy is a common topic in examinations, and it is important to know certain facts about the nerves and muscles involved. The musculocutaneous nerve is responsible for elbow flexion and supination, and typically only injured as part of a brachial plexus injury. The axillary nerve controls shoulder abduction and can be damaged in cases of humeral neck fracture or dislocation, resulting in a flattened deltoid. The radial nerve is responsible for extension in the forearm, wrist, fingers, and thumb, and can be damaged in cases of humeral midshaft fracture, resulting in wrist drop. The median nerve controls the LOAF muscles and can be damaged in cases of carpal tunnel syndrome or elbow injury. The ulnar nerve controls wrist flexion and can be damaged in cases of medial epicondyle fracture, resulting in a claw hand. The long thoracic nerve controls the serratus anterior and can be damaged during sports or as a complication of mastectomy, resulting in a winged scapula. The brachial plexus can also be damaged, resulting in Erb-Duchenne palsy or Klumpke injury, which can cause the arm to hang by the side and be internally rotated or associated with Horner’s syndrome, respectively.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 2
Incorrect
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A 47-year-old man is undergoing a block dissection of the groin for a malignant melanoma. During the surgery, the femoral triangle is being explored to control intraoperative bleeding. What structure forms the medial border of the femoral triangle?
Your Answer: Sartorius
Correct Answer: Adductor longus
Explanation:The adductor canal is bordered laterally by the vastus medialis and its roof is formed by the sartorius muscle. The adductor longus muscle forms the medial boundary of the femoral triangle.
The Adductor Canal: Anatomy and Contents
The adductor canal, also known as Hunter’s or the subsartorial canal, is a structure located in the middle third of the thigh, immediately distal to the apex of the femoral triangle. It is bordered laterally by the vastus medialis muscle and posteriorly by the adductor longus and adductor magnus muscles. The roof of the canal is formed by the sartorius muscle. The canal terminates at the adductor hiatus.
The adductor canal contains three important structures: the saphenous nerve, the superficial femoral artery, and the superficial femoral vein. The saphenous nerve is a sensory nerve that supplies the skin of the medial leg and foot. The superficial femoral artery is a major artery that supplies blood to the lower limb. The superficial femoral vein is a large vein that drains blood from the lower limb.
In order to expose the contents of the adductor canal, the sartorius muscle must be removed. Understanding the anatomy and contents of the adductor canal is important for medical professionals who perform procedures in this area, such as nerve blocks or vascular surgeries.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 3
Incorrect
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Which of the following statements about the ankle joint is false?
Your Answer: Three groups of ligaments provide mechanical stability
Correct Answer: The sural nerve lies medial to the Achilles tendon at its point of insertion
Explanation:The distal fibula is located in front of the sural nerve. Subtalar movements involve inversion and eversion. When passing behind the medial malleolus from front to back, the structures include the tibialis posterior, flexor digitorum longus, posterior tibial vein, posterior tibial artery, nerve, and flexor hallucis longus.
Anatomy of the Ankle Joint
The ankle joint is a type of synovial joint that is made up of the tibia and fibula superiorly and the talus inferiorly. It is supported by several ligaments, including the deltoid ligament, lateral collateral ligament, and talofibular ligaments. The calcaneofibular ligament is separate from the fibrous capsule of the joint, while the two talofibular ligaments are fused with it. The syndesmosis is composed of the antero-inferior tibiofibular ligament, postero-inferior tibiofibular ligament, inferior transverse tibiofibular ligament, and interosseous ligament.
The ankle joint allows for plantar flexion and dorsiflexion movements, with a range of 55 and 35 degrees, respectively. Inversion and eversion movements occur at the level of the sub talar joint. The ankle joint is innervated by branches of the deep peroneal and tibial nerves.
Reference:
Golano P et al. Anatomy of the ankle ligaments: a pictorial essay. Knee Surg Sports Traumatol Arthrosc. 2010 May;18(5):557-69. -
This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 4
Incorrect
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Which muscle is responsible for causing flexion of the interphalangeal joint of the index finger?
Your Answer: Adductor pollicis
Correct Answer: Flexor pollicis longus
Explanation:There are a total of 8 muscles that are involved in the movement of the thumb. These include two flexors, namely flexor pollicis brevis and flexor pollicis longus, two extensors, namely extensor pollicis brevis and longus, two abductors, namely abductor pollicis brevis and longus, one adductor, namely adductor pollicis, and one muscle that opposes the thumb by rotating the CMC joint, known as opponens pollicis. The flexor and extensor longus muscles are responsible for moving both the MCP and IP joints and insert on the distal phalanx.
Anatomy of the Hand: Fascia, Compartments, and Tendons
The hand is composed of bones, muscles, and tendons that work together to perform various functions. The bones of the hand include eight carpal bones, five metacarpals, and 14 phalanges. The intrinsic muscles of the hand include the interossei, which are supplied by the ulnar nerve, and the lumbricals, which flex the metacarpophalangeal joints and extend the interphalangeal joint. The thenar eminence contains the abductor pollicis brevis, opponens pollicis, and flexor pollicis brevis, while the hypothenar eminence contains the opponens digiti minimi, flexor digiti minimi brevis, and abductor digiti minimi.
The fascia of the palm is thin over the thenar and hypothenar eminences but relatively thick elsewhere. The palmar aponeurosis covers the soft tissues and overlies the flexor tendons. The palmar fascia is continuous with the antebrachial fascia and the fascia of the dorsum of the hand. The hand is divided into compartments by fibrous septa, with the thenar compartment lying lateral to the lateral septum, the hypothenar compartment lying medial to the medial septum, and the central compartment containing the flexor tendons and their sheaths, the lumbricals, the superficial palmar arterial arch, and the digital vessels and nerves. The deepest muscular plane is the adductor compartment, which contains adductor pollicis.
The tendons of the flexor digitorum superficialis (FDS) and flexor digitorum profundus (FDP) enter the common flexor sheath deep to the flexor retinaculum. The tendons enter the central compartment of the hand and fan out to their respective digital synovial sheaths. The fibrous digital sheaths contain the flexor tendons and their synovial sheaths, extending from the heads of the metacarpals to the base of the distal phalanges.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 5
Correct
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A 68-year-old woman arrives at the emergency department with a complaint of a painful, red toe. The pain began a few hours ago and has been getting worse. Upon examination, her 1st metatarsophalangeal joint is inflamed, erythematous, and tender to the touch.
What are the joint aspiration findings that would confirm a gout flare diagnosis?Your Answer: Negatively birefringent needle-shaped monosodium urate crystals
Explanation:Joint aspiration is a valuable diagnostic tool for differentiating between various causes of joint swelling, including septic arthritis and pseudogout. In the case of gout, joint aspiration will reveal needle-shaped monosodium urate crystals that are negatively birefringent under polarised light. These crystals form when uric acid levels remain persistently high and deposit in tissues, leading to the characteristic inflammatory response seen in gout.
It is important to note that a green-colored aspirate with a positive gram stain for Staphylococcus aureus is not indicative of gout, but rather suggests septic arthritis. In this case, the aspirate may have a raised white cell count and appear yellow or green.
Similarly, the presence of negatively birefringent needle-shaped calcium oxalate crystals is not associated with gout, but rather with kidney stones. These crystals form when there are high concentrations of calcium oxalate in the urine and are typically octahedral or envelope-shaped.
Finally, positively birefringent rhomboid-shaped calcium pyrophosphate crystals are not seen in gout, but rather in pseudogout. Pseudogout presents with similar symptoms to gout and more commonly affects the knee joint.
Understanding Gout: Symptoms and Diagnosis
Gout is a type of arthritis that causes inflammation and pain in the joints. Patients experience episodes of intense pain that can last for several days, followed by periods of no symptoms. The acute episodes usually reach their peak within 12 hours and can affect various joints, with the first metatarsophalangeal joint being the most commonly affected. Swelling and redness are also common symptoms of gout.
If left untreated, repeated acute episodes of gout can lead to joint damage and chronic joint problems. To diagnose gout, doctors may perform synovial fluid analysis to look for needle-shaped, negatively birefringent monosodium urate crystals under polarised light. Uric acid levels may also be checked once the acute episode has subsided, as they can be high, normal, or low during the attack.
Radiological features of gout include joint effusion, well-defined punched-out erosions with sclerotic margins, and eccentric erosions. Unlike rheumatoid arthritis, gout does not cause periarticular osteopenia. Soft tissue tophi may also be visible.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 6
Incorrect
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A 35-year-old male patient arrives at the emergency department following a bicycle accident. He reports experiencing pain and swelling in his right hand and has difficulty moving his thumb. Upon examination, there is reduced range of motion of the thumb and palpable tenderness over the anatomical snuffbox. However, his hand is neurovascularly intact. Can you identify the structures that form the lateral border of this anatomical landmark?
Your Answer: Extensor pollicis brevis and adductor pollicis longus muscles
Correct Answer: Extensor pollicis brevis and abductor pollicis longus tendon
Explanation:The tendons of the extensor pollicis brevis and abductor pollicis longus form the lateral border of the anatomical snuffbox, not the muscles themselves. This patient’s pain and tenderness over the anatomical snuffbox suggest a likely scaphoid fracture, which is a common injury resulting from a fall on an outstretched hand. It is important to keep in mind the boundaries of the anatomical snuffbox, which include the tendons of the extensor pollicis longus, brevis, and abductor pollicis muscles. The proximal border is the styloid process of the radius, the distal border is the apex of the snuffbox triangle, and the floor is made up of the trapezium and scaphoid bones.
The Anatomical Snuffbox: A Triangle on the Wrist
The anatomical snuffbox is a triangular depression located on the lateral aspect of the wrist. It is bordered by tendons of the extensor pollicis longus, extensor pollicis brevis, and abductor pollicis longus muscles, as well as the styloid process of the radius. The floor of the snuffbox is formed by the trapezium and scaphoid bones. The apex of the triangle is located distally, while the posterior border is formed by the tendon of the extensor pollicis longus. The radial artery runs through the snuffbox, making it an important landmark for medical professionals.
In summary, the anatomical snuffbox is a small triangular area on the wrist that is bordered by tendons and bones. It is an important landmark for medical professionals due to the presence of the radial artery.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 7
Incorrect
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A 20-year-old man comes to the GP complaining of loss of sensation on the lateral side of his right forearm after lifting weights. During the examination, the GP observes a decrease in the biceps reflex on the right arm.
What nerve roots are likely to be affected in this case?Your Answer: T1, T2
Correct Answer: C5, C6
Explanation:The biceps muscle is innervated by the nerve roots C5 and C6. Based on the patient’s history, it is likely that these nerves have been injured. The biceps reflex specifically tests the function of the C5 nerve root. Additionally, damage to the C6 nerve root can result in a loss of sensation in the lateral forearm.
Anatomy of the Vertebral Column
The vertebral column is composed of 33 vertebrae, which are divided into four regions: cervical, thoracic, lumbar, and sacral. The cervical region has seven vertebrae, the thoracic region has twelve, the lumbar region has five, and the sacral region has five. However, the spinal cord segmental levels do not always correspond to the vertebral segments. For example, the C8 cord is located at the C7 vertebrae, and the T12 cord is situated at the T8 vertebrae.
The cervical vertebrae are located in the neck and are responsible for controlling the muscles of the upper extremities. The C3 cord contains the phrenic nucleus, which controls the diaphragm. The thoracic vertebrae are defined by those that have a rib and control the intercostal muscles and associated dermatomes. The lumbosacral vertebrae are located in the lower back and control the hip and leg muscles, as well as the buttocks and anal regions.
The spinal cord ends at the L1-L2 vertebral level, and below this level is a spray of spinal roots called the cauda equina. Injuries below L2 represent injuries to spinal roots rather than the spinal cord proper. Understanding the anatomy of the vertebral column is essential for diagnosing and treating spinal cord injuries and other related conditions.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 8
Correct
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During pronation and supination, which bones are involved in movement?
Your Answer: Rotation of the radius on the ulna
Explanation:The movement of the arm’s pronation and supination is caused by the rotation of the radius bone, while the ulna bone remains still. This movement involves two joints: the proximal and distal radio-ulnar joints. The humerus bone remains stationary during this process, while the radial head rotates on the humerus’s capitulum. It’s worth noting that the distal carpal bones don’t move in relation to the distal radius during pronation and supination.
Anatomy of the Radius Bone
The radius bone is one of the two long bones in the forearm that extends from the lateral side of the elbow to the thumb side of the wrist. It has two expanded ends, with the distal end being the larger one. The upper end of the radius bone has articular cartilage that covers the medial to lateral side and articulates with the radial notch of the ulna by the annular ligament. The biceps brachii muscle attaches to the tuberosity of the upper end.
The shaft of the radius bone has several muscle attachments. The upper third of the body has the supinator, flexor digitorum superficialis, and flexor pollicis longus muscles. The middle third of the body has the pronator teres muscle, while the lower quarter of the body has the pronator quadratus muscle and the tendon of supinator longus.
The lower end of the radius bone is quadrilateral in shape. The anterior surface is covered by the capsule of the wrist joint, while the medial surface has the head of the ulna. The lateral surface ends in the styloid process, and the posterior surface has three grooves that contain the tendons of extensor carpi radialis longus and brevis, extensor pollicis longus, and extensor indicis. Understanding the anatomy of the radius bone is crucial in diagnosing and treating injuries and conditions that affect this bone.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 9
Incorrect
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A 27-year-old renal transplant recipient due to polycystic kidney disease visits the follow-up clinic. She has been prescribed mycophenolate mofetil as part of her immunosuppressant regimen.
What is the mechanism of action of mycophenolate mofetil?Your Answer: Calcineurin inhibitor
Correct Answer: Inosine-5'-monophosphate dehydrogenase inhibitor
Explanation:Mycophenolate mofetil (MMF) is an immunosuppressant that inhibits inosine-5′-monophosphate dehydrogenase, an enzyme necessary for purine synthesis. MMF is commonly used in organ transplantation and autoimmune disorders. Azathioprine also inhibits purine synthesis, but through a different mechanism.
Calcineurin inhibitors, such as tacrolimus and ciclosporin, reduce T-cell differentiation to suppress the immune system.
Protease inhibitors, like ritonavir and darunavir, are antivirals used to treat HIV and hepatitis.
HMG-CoA reductase inhibitors, such as statins, lower LDL cholesterol levels.
Hydroxycarbamide is a ribonucleotide reductase inhibitor that reduces the production of deoxyribonucleotides, thereby decreasing DNA synthesis. It is used to treat cancer.
Mycophenolate Mofetil: How it Works as an Immunosuppressant
Mycophenolate mofetil is a medication that is often prescribed to prevent the rejection of organ transplants. It works by inhibiting the activity of inosine monophosphate dehydrogenase, an enzyme that is necessary for the synthesis of purines. Since T and B cells rely heavily on this pathway for their proliferation, mycophenolate mofetil can effectively reduce the activity of these immune cells.
In simpler terms, mycophenolate mofetil works by blocking a key enzyme that immune cells need to grow and multiply. By doing so, it can help prevent the body from attacking and rejecting a transplanted organ. This medication is often used in combination with other immunosuppressants to achieve the best possible outcomes for transplant patients.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 10
Incorrect
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A 25-year-old woman is stabbed in the buttock and receives sutures in the emergency department. When she visits the clinic eight weeks later, she presents with a waddling gait and difficulty with thigh abduction. Upon examination, she exhibits buttock muscle wasting. Which nerve was damaged in the injury?
Your Answer: Femoral nerve
Correct Answer: Superior gluteal nerve
Explanation:If the superior gluteal nerve is damaged, it will cause a Trendelenburg gait.
The Trendelenburg Test: Assessing Gluteal Nerve Function
The Trendelenburg test is a diagnostic tool used to assess the function of the superior gluteal nerve. This nerve is responsible for the contraction of the gluteus medius muscle, which is essential for maintaining balance and stability while standing on one leg.
When the superior gluteal nerve is injured or damaged, the gluteus medius muscle is weakened, resulting in a compensatory shift of the body towards the unaffected side. This shift is characterized by a gravitational shift, which causes the body to be supported on the unaffected limb.
To perform the Trendelenburg test, the patient is asked to stand on one leg while the physician observes the position of the pelvis. In a healthy individual, the gluteus medius muscle contracts as soon as the contralateral leg leaves the floor, preventing the pelvis from dipping towards the unsupported side. However, in a person with paralysis of the superior gluteal nerve, the pelvis on the unsupported side descends, indicating that the gluteus medius on the affected side is weak or non-functional. This is known as a positive Trendelenburg test.
It is important to note that the Trendelenburg test is also used in vascular investigations to determine the presence of saphenofemoral incompetence. In this case, tourniquets are placed around the upper thigh to assess blood flow. However, in the context of assessing gluteal nerve function, the Trendelenburg test is a valuable tool for diagnosing and treating motor deficits and gait abnormalities.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 11
Incorrect
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A 6-year-old girl is brought to the clinic by her mother who is worried about her daughter's hearing loss. The girl has a history of frequent bone fractures. During the examination, the doctor observes that the external ear canal and tympanic membrane appear normal and there is no discharge or swelling. However, the girl's sclera has a bluish tint. What type of collagen is most likely affected in this case?
Your Answer: Type 3
Correct Answer: Type 1
Explanation:Osteogenesis imperfecta is caused by a defect in type 1 collagen, which is found in the skin, tendons, vasculature, and bones. This abnormality results in fragile bones, leading to multiple fractures, as seen in a child with deafness, blue sclera, and fractures. Type 2 collagen is present in cartilage and is not typically affected in osteogenesis imperfecta. Type 3 collagen is the primary component of reticular fibers, which are also not typically affected in this condition. Type 4 collagen makes up basement membranes, which are also not typically affected in osteogenesis imperfecta.
Understanding Osteogenesis Imperfecta
Osteogenesis imperfecta, also known as brittle bone disease, is a group of disorders that affect collagen metabolism, leading to bone fragility and fractures. The most common type of osteogenesis imperfecta is type 1, which is inherited in an autosomal dominant manner and is caused by decreased synthesis of pro-alpha 1 or pro-alpha 2 collagen polypeptides.
This condition typically presents in childhood, with individuals experiencing fractures following minor trauma. Other common features include blue sclera, deafness secondary to otosclerosis, and dental imperfections. Despite these symptoms, adjusted calcium, phosphate, parathyroid hormone, and ALP results are usually normal in individuals with osteogenesis imperfecta.
Overall, understanding the symptoms and underlying causes of osteogenesis imperfecta is crucial for proper diagnosis and management of this condition.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 12
Incorrect
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A 26-year-old male comes to the emergency department after sustaining a foot injury from a sliding tackle while playing soccer. He is a healthy young man with no notable medical history and is a non-smoker.
During the examination, it is observed that he has lost sensation in the posterolateral leg and lateral foot.
Which nerve is most likely to have been damaged?Your Answer: Superficial fibular nerve
Correct Answer: Sural nerve
Explanation:The sural nerve provides sensory innervation to the posterolateral leg and lateral foot, while the saphenous nerve innervates the medial aspect of the leg and foot. The lateral femoral cutaneous nerve supplies the lateral thigh.
Cutaneous Sensation in the Foot
Cutaneous sensation in the foot is the ability to feel touch, pressure, temperature, and pain on the skin of the foot. Different regions of the foot are innervated by different nerves, which are responsible for transmitting sensory information to the brain. The lateral plantar region is innervated by the sural nerve, while the dorsum (excluding the 1st web space) is innervated by the superficial peroneal nerve. The 1st web space is innervated by the deep peroneal nerve, and the extremities of the toes are innervated by the medial and lateral plantar nerves. The proximal plantar region is innervated by the tibial nerve, while the medial plantar region is innervated by the medial plantar nerve and the lateral plantar region is innervated by the lateral plantar nerve. Understanding the innervation of the foot is important for diagnosing and treating conditions that affect cutaneous sensation in this area.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 13
Incorrect
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A 42-year-old man has been experiencing mechanical back pain for a few years. Upon waking up one morning, he experiences a sudden onset of pain in his back that travels down his left leg. What is the most probable cause of his symptoms?
Your Answer: Prolapse of outer annulus fibrosus
Correct Answer: Prolapse of nucleus pulposus
Explanation:The cause of the symptoms is likely to be intervertebral disk prolapse, which occurs when the nucleus pulposus herniates.
Intervertebral Discs
Intervertebral discs are composed of two main parts: the outer annulus fibrosus and the inner nucleus pulposus. The annulus fibrosus is made up of multiple layers of fibrocartilage, while the nucleus pulposus contains loose fibers suspended in a mucoprotein gel with a jelly-like consistency. The nucleus of the disc acts as a shock absorber, and pressure on the disc can cause the posterior protrusion of the nucleus pulposus. This is most commonly seen in the lumbrosacral and lower cervical areas.
The discs are separated by hyaline cartilage, and there is one disc between each pair of vertebrae, except for C1/2 and the sacrococcygeal vertebrae. Understanding the structure and function of intervertebral discs is important in the diagnosis and treatment of spinal conditions. By providing support and cushioning to the spine, these discs play a crucial role in maintaining spinal health and mobility.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 14
Incorrect
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Liam is a 5-year-old boy playing outside in the park on his scooter. He accidentally falls off his scooter and scrapes his elbow, causing a small amount of bleeding. After a few days, a scab forms and eventually falls off, leaving the skin healed. What is the outermost layer of the epidermis?
Your Answer:
Correct Answer: Stratum corneum
Explanation:The epidermis comprises five distinct layers that consist of various cell types and perform different functions. These layers, listed from outermost to innermost, are the stratum corneum, stratum lucidum*, and stratum granulosum.
The Layers of the Epidermis
The epidermis is the outermost layer of the skin and is made up of a stratified squamous epithelium with a basal lamina underneath. It can be divided into five layers, each with its own unique characteristics. The first layer is the stratum corneum, which is made up of flat, dead, scale-like cells filled with keratin. These cells are continually shed and replaced with new ones. The second layer, the stratum lucidum, is only present in thick skin and is a clear layer. The third layer, the stratum granulosum, is where cells form links with their neighbors. The fourth layer, the stratum spinosum, is the thickest layer of the epidermis and is where squamous cells begin keratin synthesis. Finally, the fifth layer is the stratum germinativum, which is the basement membrane and is made up of a single layer of columnar epithelial cells. This layer gives rise to keratinocytes and contains melanocytes. Understanding the layers of the epidermis is important for understanding the structure and function of the skin.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 15
Incorrect
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A 43-year-old man comes to the clinic complaining of a painful rash on his left anterior chest wall that extends to his back and under his armpit, but does not cross the midline. The rash has been present for one day, and he has been feeling lethargic for three days. Based on these symptoms, what virus do you suspect is causing his condition?
Your Answer:
Correct Answer: Varicella zoster virus
Explanation:The Varicella zoster virus (VZV) is the correct answer. Shingles is a painful rash that typically appears in a dermatomal distribution and does not usually cross the mid-line. VZV is the virus responsible for causing chickenpox, and after the initial infection, it can remain dormant in nerve cells for many years. Shingles occurs when VZV reactivates. Additional information on shingles can be found below.
Epstein-Barr virus is primarily linked to infectious mononucleosis (glandular fever).
Human papillomavirus (HPV) is associated with viral warts, and some strains are linked to gynecological malignancies. Due to their potential to cause cancer, some types of HPV are now vaccinated against.
Herpes simplex virus is associated with oral or genital herpes infections.
Shingles is a painful blistering rash caused by reactivation of the varicella-zoster virus. It is more common in older individuals and those with immunosuppressive conditions. The diagnosis is usually clinical and management includes analgesia, antivirals, and reminding patients they are potentially infectious. Complications include post-herpetic neuralgia, herpes zoster ophthalmicus, and herpes zoster oticus. Antivirals should be used within 72 hours to reduce the incidence of post-herpetic neuralgia.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 16
Incorrect
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A 26-year-old male suffers a fall resulting in a scaphoid bone fracture. What is the primary source of blood supply for the scaphoid bone?
Your Answer:
Correct Answer: From the distal end
Explanation:Due to the fact that the blood supply to the scaphoid enters from a small non-articular surface near its distal end, there is a risk of non-union with transverse fractures of the scaphoid.
The scaphoid bone has various articular surfaces for different bones in the wrist. It has a concave surface for the head of the capitate and a crescentic surface for the lunate. The proximal end has a wide convex surface for the radius, while the distal end has a tubercle that can be felt. The remaining articular surface faces laterally and is associated with the trapezium and trapezoid bones. The narrow strip between the radial and trapezial surfaces and the tubercle gives rise to the radial collateral carpal ligament. The tubercle also receives part of the flexor retinaculum and is the only part of the scaphoid bone that allows for the entry of blood vessels. However, this area is commonly fractured and can lead to avascular necrosis.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 17
Incorrect
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Which one of the following structures does not pass behind the medial malleolus?
Your Answer:
Correct Answer: Tibialis anterior tendon
Explanation:Anatomy of the Lateral Malleolus
The lateral malleolus is a bony prominence on the outer side of the ankle joint. Posterior to the lateral malleolus and superficial to the superior peroneal retinaculum are the sural nerve and short saphenous vein. These structures are important for sensation and blood flow to the lower leg and foot.
On the other hand, posterior to the lateral malleolus and deep to the superior peroneal retinaculum are the peroneus longus and peroneus brevis tendons. These tendons are responsible for ankle stability and movement.
Additionally, the calcaneofibular ligament is attached at the lateral malleolus. This ligament is important for maintaining the stability of the ankle joint and preventing excessive lateral movement.
Understanding the anatomy of the lateral malleolus is crucial for diagnosing and treating ankle injuries and conditions. Proper care and management of these structures can help prevent long-term complications and improve overall ankle function.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 18
Incorrect
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A 67-year-old female presents to her primary healthcare provider with painful blisters on her gingival and buccal mucosa and skin that easily rupture and cause ulcers. The oral blisters began three months ago and the cutaneous lesions just a week ago. She has a medical history of hypertension, vitiligo, and type 2 diabetes mellitus. Upon examination of the oral cavity and skin, scattered shallow ulcerations ranging from 8 mm to 1 cm in diameter were observed. A biopsy of the lesions revealed acantholysis. The patient has been prescribed corticosteroids.
What is the most likely cause of this condition in the patient?Your Answer:
Correct Answer: Antibodies against desmoglein 3
Explanation:Pemphigus vulgaris is an autoimmune condition that occurs when the body’s immune system attacks desmoglein 3, a type of cell adhesion molecule found in epithelial cells. This disease is more prevalent in the Ashkenazi Jewish population. The most common symptom is mucosal ulceration, which can be the first sign of the disease. Oral involvement is seen in 50-70% of patients. Skin blistering is also a common symptom, with easily ruptured vesicles and bullae. These lesions are typically painful but not itchy and may appear months after the initial mucosal symptoms. Nikolsky’s sign is a characteristic feature of pemphigus vulgaris, where bullae spread following the application of horizontal, tangential pressure to the skin. Biopsy results often show acantholysis.
The first-line treatment for pemphigus vulgaris is steroids, which help to reduce inflammation and suppress the immune system. Immunosuppressants may also be used to manage the disease.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 19
Incorrect
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Sarah, a 30-year-old woman presents to the emergency department with severe pain in her left big toe. Her first MTP joint is swollen, hot, and red. She is seen biting her nails and hitting her head against the wall. Her caregiver informs you that this is her usual behavior.
Upon joint aspiration, negative birefringent needle-shaped crystals are found. Sarah's medical history includes a learning disability, depression, and asthma. She takes sertraline for depression and frequently uses hydrocortisone cream for eczema. Sarah does not consume red meat and prefers a vegetable-based diet.
What factors predispose Sarah to this type of crystalline arthritis?Your Answer:
Correct Answer: Lesch-Nyhan syndrome
Explanation:If an individual with learning difficulties and a history of gout exhibits self-mutilating behaviors such as head-banging or nail-biting, it may indicate the presence of Lesch-Nyhan syndrome. However, risk factors for gout do not include sertraline, hydrocortisone, or asthma, but rather red meat consumption. Lesch-Nyhan syndrome is an X-linked recessive condition caused by a deficiency in hypoxanthine-guanine phosphoribosyl transferase (HGPRTase) and is characterized by hyperuricemia, learning disability, self-mutilating behavior, gout, and renal failure.
Predisposing Factors for Gout
Gout is a type of synovitis caused by the accumulation of monosodium urate monohydrate in the synovium. This condition is triggered by chronic hyperuricaemia, which is characterized by uric acid levels exceeding 0.45 mmol/l. There are two main factors that contribute to the development of hyperuricaemia: decreased excretion of uric acid and increased production of uric acid.
Decreased excretion of uric acid can be caused by various factors, including the use of diuretics, chronic kidney disease, and lead toxicity. On the other hand, increased production of uric acid can be triggered by myeloproliferative/lymphoproliferative disorders, cytotoxic drugs, and severe psoriasis.
In rare cases, gout can also be caused by genetic disorders such as Lesch-Nyhan syndrome, which is characterized by hypoxanthine-guanine phosphoribosyl transferase (HGPRTase) deficiency. This condition is x-linked recessive, which means it is only seen in boys. Lesch-Nyhan syndrome is associated with gout, renal failure, neurological deficits, learning difficulties, and self-mutilation.
It is worth noting that aspirin in low doses (75-150mg) is not believed to have a significant impact on plasma urate levels. Therefore, the British Society for Rheumatology recommends that it should be continued if necessary for cardiovascular prophylaxis.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 20
Incorrect
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Which muscle initiates abduction of the shoulder at an early age?
Your Answer:
Correct Answer: Supraspinatus
Explanation:The primary function of the intermediate deltoid muscle is to abduct the humerus, but it relies on the supraspinatus muscle to initiate this movement. Rotator cuff disease often involves damage to the supraspinatus tendon.
The shoulder joint is a shallow synovial ball and socket joint that is inherently unstable but capable of a wide range of movement. Stability is provided by the muscles of the rotator cuff. The glenoid labrum is a fibrocartilaginous rim attached to the free edge of the glenoid cavity. The fibrous capsule attaches to the scapula, humerus, and tendons of various muscles. Movements of the shoulder joint are controlled by different muscles. The joint is closely related to important anatomical structures such as the brachial plexus, axillary artery and vein, and various nerves and vessels.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 21
Incorrect
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A 32-year-old cyclist has fallen off his bicycle and landed on an outstretched arm. He complains of pain and swelling in his left shoulder. Upon examination, the shoulder is tender and swollen to the touch. The patient experiences pain when attempting active and passive movement of the shoulder joint. A radiograph is ordered, which reveals an undisplaced fracture of the surgical neck of the humerus. What muscle, in addition to the deltoid muscle, is supplied by the axillary nerve, which is commonly injured in cases of surgical neck humerus fractures? Choose from the following options: subscapularis, teres major, supraspinatus, teres minor, or infraspinatus.
Your Answer:
Correct Answer: Teres minor
Explanation:The teres minor is the correct answer, as it is a rotator cuff muscle. The supraspinatus and infraspinatus are also rotator cuff muscles that are innervated by the suprascapular nerve, while the subscapularis is innervated by the superior and inferior subscapular nerves. The teres major, however, is not a rotator cuff muscle and is innervated by the inferior subscapular nerve. Fractures of the surgical neck of the humerus can result in injury to the axillary nerve and posterior circumflex artery, making it important to test for axillary nerve function by checking sensation in the ‘regimental badge’ area of the arm and observing shoulder movements.
Understanding the Rotator Cuff Muscles
The rotator cuff muscles are a group of four muscles that are responsible for the movement and stability of the shoulder joint. These muscles are known as the SItS muscles, which stands for Supraspinatus, Infraspinatus, teres minor, and Subscapularis. Each of these muscles has a specific function in the movement of the shoulder joint.
The Supraspinatus muscle is responsible for abducting the arm before the deltoid muscle. It is the most commonly injured muscle in the rotator cuff. The Infraspinatus muscle rotates the arm laterally, while the teres minor muscle adducts and rotates the arm laterally. Lastly, the Subscapularis muscle adducts and rotates the arm medially.
Understanding the functions of each of these muscles is important in diagnosing and treating rotator cuff injuries. By identifying which muscle is injured, healthcare professionals can develop a treatment plan that targets the specific muscle and promotes healing. Overall, the rotator cuff muscles play a crucial role in the movement and stability of the shoulder joint.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 22
Incorrect
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A 25-year-old male is scheduled for hernia repair surgery where the mesh will be sutured to the inguinal ligament. What is the origin of the inguinal ligament?
Your Answer:
Correct Answer: External oblique aponeurosis
Explanation:The external oblique aponeurosis forms the inguinal ligament, which extends from the pubic tubercle to the anterior superior iliac spine.
Muscles and Layers of the Abdominal Wall
The abdominal wall is composed of various muscles and layers that provide support and protection to the organs within the abdominal cavity. The two main muscles of the abdominal wall are the rectus abdominis and the quadratus lumborum. The rectus abdominis is located anteriorly, while the quadratus lumborum is located posteriorly.
The remaining abdominal wall is made up of three muscular layers, each passing from the lateral aspect of the quadratus lumborum to the lateral margin of the rectus sheath. These layers are muscular posterolaterally and aponeurotic anteriorly. The external oblique muscle lies most superficially and originates from the 5th to 12th ribs, inserting into the anterior half of the outer aspect of the iliac crest, linea alba, and pubic tubercle. The internal oblique arises from the thoracolumbar fascia, the anterior 2/3 of the iliac crest, and the lateral 2/3 of the inguinal ligament, while the transversus abdominis is the innermost muscle, arising from the inner aspect of the costal cartilages of the lower 6 ribs, the anterior 2/3 of the iliac crest, and the lateral 1/3 of the inguinal ligament.
During abdominal surgery, it is often necessary to divide either the muscles or their aponeuroses. It is desirable to divide the aponeurosis during a midline laparotomy, leaving the rectus sheath intact above the arcuate line and the muscles intact below it. Straying off the midline can lead to damage to the rectus muscles, particularly below the arcuate line where they may be in close proximity to each other. The nerve supply for these muscles is the anterior primary rami of T7-12.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 23
Incorrect
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At what level does the inferior thyroid artery penetrate the thyroid gland?
Your Answer:
Correct Answer: C6
Explanation:Surface Anatomy of the Neck: Identifying Structures and Corresponding Levels
The neck is a complex region of the body that contains numerous structures and landmarks. By understanding the surface anatomy of the neck, healthcare professionals can accurately identify and locate important structures during physical examinations and medical procedures.
In the midline of the neck, several structures can be felt from top to bottom. These include the hyoid at the level of C3, the notch of the thyroid cartilage at C4, and the cricoid cartilage at C6. The lower border of the cricoid cartilage is particularly significant as it corresponds to several important structures, including the junction of the larynx and trachea, the junction of the pharynx and esophagus, and the level at which the inferior thyroid artery enters the thyroid gland. Additionally, the vertebral artery enters the transverse foramen in the 6th cervical vertebrae at this level, and the superior belly of the omohyoid muscle crosses the carotid sheath. The middle cervical sympathetic ganglion is also located at this level, as well as the carotid tubercle, which can be used to compress the carotid artery.
Overall, understanding the surface anatomy of the neck is crucial for healthcare professionals to accurately identify and locate important structures during physical examinations and medical procedures.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 24
Incorrect
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A 26-year-old male presents to his primary care physician complaining of anterior hip pain that exacerbates when he lifts his thigh towards his chest. Upon further inquiry, the physician discovers that the patient is an avid runner and runs more than 60 km per week. The physician suspects that the pain may be a result of the patient overusing his hip flexor muscles.
Based on the physician's suspicion, which muscle is the most probable to be impacted?Your Answer:
Correct Answer: Iliopsoas
Explanation:Although Pectineus is a hip flexor, it is not as significant as iliopsoas in this function. Its origin is the pubic bone, and it inserts into the femur. Additionally, it assists in adducting and internally rotating the thigh.
The Psoas Muscle: Origin, Insertion, Innervation, and Action
The psoas muscle is a deep-seated muscle that originates from the transverse processes of the five lumbar vertebrae and the superficial part originates from T12 and the first four lumbar vertebrae. It inserts into the lesser trochanter of the femur and is innervated by the anterior rami of L1 to L3.
The main action of the psoas muscle is flexion and external rotation of the hip. When both sides of the muscle contract, it can raise the trunk from the supine position. The psoas muscle is an important muscle for maintaining proper posture and movement, and it is often targeted in exercises such as lunges and leg lifts.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 25
Incorrect
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A father brings his 4-year-old son to a dermatologist concerned about his dry skin. The child was also born via spontaneous vaginal delivery at term without any complications. He has always had dry skin, but it has become more severe lately. He has a past medical history of eczema.
What clinical feature could have aided in the diagnosis of ichthyosis based on the history and examination?Your Answer:
Correct Answer: 'fish-scale' skin
Explanation:Ichthyosis is characterized by the presence of dry, scaly skin resembling fish scales.
Understanding Acquired Ichthyosis
Acquired ichthyosis is a skin condition characterized by dry and scaly skin, often referred to as crocodile skin. Unlike congenital ichthyosis, which is present at birth, acquired ichthyosis develops later in life and can be caused by various factors. Some of the known causes of acquired ichthyosis include lymphoma, particularly Hodgkin’s lymphoma, other malignancies such as Kaposi’s sarcoma, leprosy, and malnutrition.
It is important to note that acquired ichthyosis is a rare condition and is often associated with underlying medical conditions.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 26
Incorrect
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A 12-year-old boy with sickle cell anaemia arrives at the emergency department with a hot, swollen, erythematous and painful knee. The symptoms developed over a few hours and he is unable to bear weight on the affected leg. Upon joint aspiration, cloudy synovial fluid with neutrophilia is observed. What is the primary mode of transmission for this condition?
Your Answer:
Correct Answer: Hematogenous spread
Explanation:Septic arthritis is often characterized by sudden joint pain, swelling, and warmth, and is typically caused by hematogenous spread of bacteria. Staphylococcus aureus is the most common causative organism, except in individuals with sickle cell anemia, where Salmonella is more common. While direct introduction or extension from a nearby infection can also cause septic arthritis, hematogenous spread is the most frequent cause. Unlike respiratory diseases, septic arthritis is not spread through respiratory droplets. In sexually active patients, gonococcal arthritis caused by Neisseria gonorrhoeae should be considered as a potential cause.
Septic Arthritis in Adults: Causes, Symptoms, and Treatment
Septic arthritis is a condition that occurs when bacteria infect a joint, leading to inflammation and swelling. The most common organism that causes septic arthritis in adults is Staphylococcus aureus, while Neisseria gonorrhoeae is the most common organism in sexually active young adults. The infection is usually spread through the bloodstream, often from distant bacterial infections such as abscesses. The knee is the most commonly affected joint in adults.
Symptoms of septic arthritis include acute joint swelling, restricted movement, warmth to the touch, and fever. To diagnose the condition, synovial fluid sampling is necessary and should be done before administering antibiotics if needed. Blood cultures and joint imaging may also be necessary.
Treatment for septic arthritis involves intravenous antibiotics that cover Gram-positive cocci, such as flucloxacillin or clindamycin if the patient is allergic to penicillin. Antibiotics are typically given for several weeks, and patients may be switched to oral antibiotics after two weeks. Needle aspiration is used to decompress the joint, and arthroscopic lavage may be required. Overall, prompt diagnosis and treatment are essential to prevent joint damage and other complications.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 27
Incorrect
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A 29-year-old rugby player comes to your clinic with a painful shoulder. The discomfort began three weeks ago after a rugby match. Although he has experienced aches and pains after rugby before, this has been more persistent and limiting. He has been painting a room in his house and finds that the pain worsens when he reaches upward. He has been unable to participate in rugby or go to the gym. During the examination, there is tenderness on the tip of the shoulder. Both the empty can test is positive. You suspect that the patient may have a partial articular supraspinatus tendon avulsion (PASTA) lesion. Where does the supraspinatus tendon insert on the humerus?
Your Answer:
Correct Answer: Greater tubercle of the humerus
Explanation:The greater tubercle of the humerus is the correct answer. It is the insertion site for the supraspinatus muscle, which is one of three rotator cuff muscles that insert onto the greater tubercle. The infraspinatus muscle inserts onto the middle facet of the greater tubercle, while the teres minor muscle inserts onto the inferior facet.
The lesser tubercle of the humerus is located on the anteromedial aspect of the bone and is the insertion site for the subscapularis muscle, which is the remaining rotator cuff muscle.
The deltoid tuberosity is found on the lateral surface of the humeral shaft and is the insertion site for the deltoid muscle.
The intertubercular sulcus is a groove in the humerus that houses the tendon of the long head of biceps brachii. The floor of the intertubercular sulcus is the insertion site for the latissimus dorsi muscle.
The capitulum of the humerus is located at the distal end of the bone and articulates with the head of the radius.
PASTA lesions are partial tears of the supraspinatus tendon where it inserts into the humerus. They typically occur in athletes after a pulling or twisting injury.
The empty can test, also known as Jobe’s test, is used to test the supraspinatus tendon. It involves slight abduction of the arm, rotating the arm so the thumbs point downwards (as though holding two empty cans), and resisting downward pressure from the examiner. A positive test result indicates a PASTA lesion.
Understanding the Rotator Cuff Muscles
The rotator cuff muscles are a group of four muscles that are responsible for the movement and stability of the shoulder joint. These muscles are known as the SItS muscles, which stands for Supraspinatus, Infraspinatus, teres minor, and Subscapularis. Each of these muscles has a specific function in the movement of the shoulder joint.
The Supraspinatus muscle is responsible for abducting the arm before the deltoid muscle. It is the most commonly injured muscle in the rotator cuff. The Infraspinatus muscle rotates the arm laterally, while the teres minor muscle adducts and rotates the arm laterally. Lastly, the Subscapularis muscle adducts and rotates the arm medially.
Understanding the functions of each of these muscles is important in diagnosing and treating rotator cuff injuries. By identifying which muscle is injured, healthcare professionals can develop a treatment plan that targets the specific muscle and promotes healing. Overall, the rotator cuff muscles play a crucial role in the movement and stability of the shoulder joint.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 28
Incorrect
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You are in a clinic with your consultant examining a 55-year-old man who complains of shoulder pain. During the assessment, the consultant instructs the patient to place the back of his hand against the lumbar region of his back. Which muscle of the rotator cuff is responsible for this movement?
Your Answer:
Correct Answer: Subscapularis
Explanation:The subscapularis muscle is responsible for internal rotation, while the other muscles in the cuff are responsible for external rotation. During Gerber’s Test, the consultant will ask you to place the dorsum of your hand behind your back, which requires internal rotation of the humerus. This movement is facilitated by the subscapularis muscle.
Understanding the Rotator Cuff Muscles
The rotator cuff muscles are a group of four muscles that are responsible for the movement and stability of the shoulder joint. These muscles are known as the SItS muscles, which stands for Supraspinatus, Infraspinatus, teres minor, and Subscapularis. Each of these muscles has a specific function in the movement of the shoulder joint.
The Supraspinatus muscle is responsible for abducting the arm before the deltoid muscle. It is the most commonly injured muscle in the rotator cuff. The Infraspinatus muscle rotates the arm laterally, while the teres minor muscle adducts and rotates the arm laterally. Lastly, the Subscapularis muscle adducts and rotates the arm medially.
Understanding the functions of each of these muscles is important in diagnosing and treating rotator cuff injuries. By identifying which muscle is injured, healthcare professionals can develop a treatment plan that targets the specific muscle and promotes healing. Overall, the rotator cuff muscles play a crucial role in the movement and stability of the shoulder joint.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 29
Incorrect
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You are evaluating a patient with Dupuytren's contracture in a pre-operative orthopaedic clinic. You request the patient to flex their fingers at the distal interphalangeal joints.
Which muscle's function is being evaluated in this case?Your Answer:
Correct Answer: Flexor digitorum profundus
Explanation:The function of flexor digitorum profundus is to flex the fingers at both interphalangeal joints and the metacarpophalangeal joints, with a specific responsibility for flexing the distal interphalangeal joint. In contrast, flexor digitorum superficialis only flexes the metacarpophalangeal and proximal interphalangeal joints of the fingers, and must be isolated from the action of flexor digitorum profundus to assess its function. Flexor hallucis longus, on the other hand, flexes the joints of the great toe but not the distal interphalangeal joints.
The forearm flexor muscles include the flexor carpi radialis, palmaris longus, flexor carpi ulnaris, flexor digitorum superficialis, and flexor digitorum profundus. These muscles originate from the common flexor origin and surrounding fascia, and are innervated by the median and ulnar nerves. Their actions include flexion and abduction of the carpus, wrist flexion, adduction of the carpus, and flexion of the metacarpophalangeal and interphalangeal joints.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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Question 30
Incorrect
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A 25-year-old male patient arrives with a belated diagnosis of appendicitis. The appendix is located retrocaecally and has resulted in a psoas abscess due to perforation. What is the structure that the psoas major muscle inserts into?
Your Answer:
Correct Answer: Lesser trochanter of the femur
Explanation:The lesser trochanter is the insertion point of the psoas major.
The Psoas Muscle: Origin, Insertion, Innervation, and Action
The psoas muscle is a deep-seated muscle that originates from the transverse processes of the five lumbar vertebrae and the superficial part originates from T12 and the first four lumbar vertebrae. It inserts into the lesser trochanter of the femur and is innervated by the anterior rami of L1 to L3.
The main action of the psoas muscle is flexion and external rotation of the hip. When both sides of the muscle contract, it can raise the trunk from the supine position. The psoas muscle is an important muscle for maintaining proper posture and movement, and it is often targeted in exercises such as lunges and leg lifts.
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This question is part of the following fields:
- Musculoskeletal System And Skin
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