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  • Question 1 - A 38-year-old man presents with pruritic, violaceous papules in a polygonal pattern on...

    Incorrect

    • A 38-year-old man presents with pruritic, violaceous papules in a polygonal pattern on the flexor surface of his forearms. Several of these papules have merged to form plaques. What is the probable diagnosis?

      Your Answer: Psoriasis

      Correct Answer: Lichen planus

      Explanation:

      Lichen planus is a rash that appears as purple, itchy, polygonal papules on the flexor surfaces of the body. It is often accompanied by Wickham’s striae on the surface and can also affect the mouth. In contrast, lichen sclerosus is characterized by white, itchy spots that commonly appear on the vulva of older women.

      Understanding Lichen Planus

      Lichen planus is a skin condition that is believed to be caused by an immune response, although the exact cause is unknown. It is characterized by an itchy, papular rash that typically appears on the palms, soles, genitalia, and flexor surfaces of the arms. The rash often has a polygonal shape and a distinctive white-lines pattern on the surface, known as Wickham’s striae. In some cases, new skin lesions may appear at the site of trauma, a phenomenon known as the Koebner phenomenon.

      Oral involvement is common in around 50% of patients, with a white-lace pattern often appearing on the buccal mucosa. Nail changes may also occur, including thinning of the nail plate and longitudinal ridging. Lichenoid drug eruptions can be caused by certain medications, such as gold, quinine, and thiazides.

      The main treatment for lichen planus is potent topical steroids. For oral lichen planus, benzydamine mouthwash or spray is recommended. In more extensive cases, oral steroids or immunosuppression may be necessary.

    • This question is part of the following fields:

      • Dermatology
      24.9
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  • Question 2 - At what age should individuals be offered human papillomavirus vaccination for the first...

    Correct

    • At what age should individuals be offered human papillomavirus vaccination for the first time?

      Your Answer: Girls and boys aged 12-13 years

      Explanation:

      Starting September 2019, boys in school Year 8 who are 12-13 years old will also be provided with the HPV vaccine, which is currently administered in two doses. Girls receive the second dose within 6-24 months after the first, depending on local guidelines.

      The human papillomavirus (HPV) is a known carcinogen that infects the skin and mucous membranes. There are numerous strains of HPV, with the most significant being 6 & 11, which cause genital warts, and 16 & 18, which are linked to various cancers, particularly cervical cancer. HPV infection is responsible for over 99.7% of cervical cancers, and testing for HPV is now a crucial part of cervical cancer screening. Other cancers linked to HPV include anal, vulval, vaginal, mouth, and throat cancers. While there are other risk factors for cervical cancer, such as smoking and contraceptive pill use, HPV is a significant contributor.

      In 2008, the UK introduced a vaccination for HPV, initially using Cervarix, which protected against HPV 16 & 18 but not 6 & 11. This decision was criticized due to the significant disease burden caused by genital warts. In 2012, Gardasil replaced Cervarix as the vaccine used, protecting against HPV 6, 11, 16 & 18. Initially given only to girls, boys were also offered the vaccine from September 2019. All 12- and 13-year-olds in school Year 8 are offered the HPV vaccine, which is typically given in school. Parents are informed that their daughter may receive the vaccine against their wishes. The vaccine is given in two doses, with the second dose administered between 6-24 months after the first, depending on local policy. Men who have sex with men under the age of 45 should also be offered the HPV vaccine to protect against anal, throat, and penile cancers. Injection site reactions are common with HPV vaccines.

    • This question is part of the following fields:

      • Reproductive Medicine
      7.3
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  • Question 3 - During a routine check-up, a 7 week-old baby boy is seen. His mother...

    Incorrect

    • During a routine check-up, a 7 week-old baby boy is seen. His mother has a history of asthma and used inhaled steroids while pregnant. He was delivered via planned Caesarian at 39 weeks due to breech presentation and weighed 3.1kg at birth. What condition is he at a higher risk for?

      Your Answer: Congenital cataract

      Correct Answer: Developmental dysplasia of the hip

      Explanation:

      If a baby was in a breech presentation, it is important to ensure that they have been referred for screening for developmental dysplasia of the hip (DDH) as it is a risk factor for this condition. The Department of Health recommends that all babies who were breech at any point from 36 weeks (even if not breech at birth), babies born before 36 weeks who were in a breech presentation, and all babies with a first degree relative who had a hip problem in early life, should undergo ultrasound screening for hip dysplasia. If one twin was breech, both should be screened. Some hospitals also refer babies with other conditions such as oligohydramnios, high birth weight, torticollis, congenital talipes calcaneovalgus, and metatarsus adductus for screening. For more information on screening for DDH, please refer to the link provided.

      Developmental dysplasia of the hip (DDH) is a condition that affects 1-3% of newborns and is more common in females, firstborn children, and those with a positive family history or breech presentation. It used to be called congenital dislocation of the hip (CDH). DDH is more often found in the left hip and can be bilateral in 20% of cases. Screening for DDH is recommended for infants with certain risk factors, and all infants are screened using the Barlow and Ortolani tests at the newborn and six-week baby check. Clinical examination includes testing for leg length symmetry, restricted hip abduction, and knee level when hips and knees are flexed. Ultrasound is used to confirm the diagnosis if clinically suspected, but x-ray is the first line investigation for infants over 4.5 months. Management includes the use of a Pavlik harness for children under 4-5 months and surgery for older children with unstable hips.

    • This question is part of the following fields:

      • Paediatrics
      26.9
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  • Question 4 - You are a foundation doctor working in general practice. You review a sixty-five-year-old...

    Correct

    • You are a foundation doctor working in general practice. You review a sixty-five-year-old gentleman with a facial rash. On examination you note a vesicular rash extending to the tip of the nose. Observations are unremarkable.
      What is your primary concern?

      Your Answer: Possible involvement of the cornea

      Explanation:

      The presence of vesicles extending to the tip of the nose, known as Hutchinson’s sign, is strongly linked to shingles affecting the eyes. This is because the trigeminal nerve branch that supplies the cornea and nasal tip is affected. While pneumonia can be associated with herpes, this patient does not exhibit any respiratory symptoms. Despite the potential for post-herpetic neuralgia from the painful rash of shingles, the primary concern for this patient is the ocular involvement indicated by Hutchinson’s sign.

      Herpes Zoster Ophthalmicus: Symptoms, Treatment, and Complications

      Herpes zoster ophthalmicus (HZO) is a condition that occurs when the varicella-zoster virus reactivates in the area supplied by the ophthalmic division of the trigeminal nerve. It is responsible for approximately 10% of shingles cases. The main symptom of HZO is a vesicular rash around the eye, which may or may not involve the eye itself. Hutchinson’s sign, a rash on the tip or side of the nose, is a strong indicator of nasociliary involvement and increases the risk of ocular involvement.

      Treatment for HZO involves oral antiviral medication for 7-10 days, ideally started within 72 hours of symptom onset. Intravenous antivirals may be necessary for severe infections or immunocompromised patients. Topical antiviral treatment is not recommended for HZO, but topical corticosteroids may be used to treat any secondary inflammation of the eye. Ocular involvement requires urgent ophthalmology review to prevent complications such as conjunctivitis, keratitis, episcleritis, anterior uveitis, ptosis, and post-herpetic neuralgia.

      In summary, HZO is a condition caused by the reactivation of the varicella-zoster virus in the ophthalmic division of the trigeminal nerve. It presents with a vesicular rash around the eye and may involve the eye itself. Treatment involves oral antiviral medication and urgent ophthalmology review is necessary for ocular involvement. Complications of HZO include various eye conditions, ptosis, and post-herpetic neuralgia.

    • This question is part of the following fields:

      • Ophthalmology
      31.7
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  • Question 5 - A 60-year-old man had a left mastectomy three years ago for breast cancer....

    Correct

    • A 60-year-old man had a left mastectomy three years ago for breast cancer. He has now presented with a 4-month history of progressive ataxia and dysarthria. On examination, there is gaze-evoked nystagmus, dysarthria, upper limb ataxia and gait ataxia. Power, tone, reflexes and sensation are normal. Plantar response is flexor bilaterally. Computerised tomography (CT) and magnetic resonance imaging (MRI) of the brain and cerebrospinal fluid (CSF) microscopy are normal.
      Which one of the following is the most likely cause of his ataxia?

      Your Answer: Paraneoplastic cerebellum syndrome

      Explanation:

      Differential diagnosis for a patient with subacute cerebellar dysfunction and normal imaging

      Paraneoplastic cerebellum syndrome, multiple sclerosis, cerebellar metastasis, malignant meningitis, and Wernicke’s encephalopathy are among the possible diagnoses for a patient presenting with subacute onset of cerebellar signs and normal imaging.

      Paraneoplastic cerebellum syndrome is a rare immune-mediated complication of many cancers, which may be diagnosed before the underlying tumour. Symptoms develop rapidly and include dizziness, nausea, vertigo, nystagmus, ataxia, oscillopsia, dysarthria, tremor, dysphagia, and blurry vision. MRI may be normal, but CSF may show raised protein and anti-neuronal antibodies.

      Multiple sclerosis is more common in women and usually presents with transient episodes of visual change or limb weakness/paraesthesiae, as well as bladder and cerebellar dysfunction. MRI may visualise plaques of demyelination, and CSF shows oligoclonal bands.

      Cerebellar metastasis could occur in breast cancer, but it would be visualised on MRI.

      Malignant meningitis occurs when cancer spreads to the meninges and presents with confusion, headaches, and weakness. Imaging and CSF would be abnormal.

      Wernicke’s encephalopathy is due to thiamine deficiency, typically seen in alcoholics, and presents with acute confusional state, ophthalmoplegia, and gait ataxia. Dysarthria is not usually a feature. Thiamine deficiency is not suggested by this patient’s history.

    • This question is part of the following fields:

      • Neurology
      30.5
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  • Question 6 - As a junior doctor in the Emergency Department, you encounter a 40-year-old woman...

    Incorrect

    • As a junior doctor in the Emergency Department, you encounter a 40-year-old woman who has been brought in by the police under a section 135. The police had to obtain a warrant as part of the process. The patient is currently agitated and speaking incoherently about religious phrases. She has a documented history of severe depression.

      What powers does section 135 grant to the police in this situation?

      Your Answer: To bring a person with suspected mental health issues in from the community

      Correct Answer: To bring a person with suspected mental health issues in from their property

      Explanation:

      If the police believe that someone requires a mental health assessment or treatment, they can request a section 135 to remove the individual from their property. The procedure involves an Approved Mental Health Practitioner (AMHP) presenting evidence at a Magistrate’s Court to obtain a warrant. This warrant permits the Police, an AMHP, and a registered medical practitioner to enter the premises and conduct an assessment or take the person to a safe location for evaluation.

      Sectioning under the Mental Health Act is a legal process used for individuals who refuse voluntary admission. This process excludes patients who are under the influence of drugs or alcohol. There are several sections under the Mental Health Act that allow for different types of admission and treatment.

      Section 2 allows for admission for assessment for up to 28 days, which is not renewable. An Approved Mental Health Professional (AMHP) or the nearest relative (NR) can make the application on the recommendation of two doctors, one of whom should be an approved consultant psychiatrist. Treatment can be given against the patient’s wishes.

      Section 3 allows for admission for treatment for up to 6 months, which can be renewed. An AMHP and two doctors, both of whom must have seen the patient within the past 24 hours, can make the application. Treatment can also be given against the patient’s wishes.

      Section 4 is used as an emergency 72-hour assessment order when a section 2 would involve an unacceptable delay. A GP and an AMHP or NR can make the application, which is often changed to a section 2 upon arrival at the hospital.

      Section 5(2) allows a doctor to legally detain a voluntary patient in hospital for 72 hours, while section 5(4) allows a nurse to detain a voluntary patient for 6 hours.

      Section 17a allows for Supervised Community Treatment (Community Treatment Order) and can be used to recall a patient to the hospital for treatment if they do not comply with the conditions of the order in the community, such as taking medication.

      Section 135 allows for a court order to be obtained to allow the police to break into a property to remove a person to a Place of Safety. Section 136 allows for someone found in a public place who appears to have a mental disorder to be taken by the police to a Place of Safety. This section can only be used for up to 24 hours while a Mental Health Act assessment is arranged.

    • This question is part of the following fields:

      • Psychiatry
      35.6
      Seconds
  • Question 7 - Which one of the following statements regarding pancreatic cancer is true? ...

    Incorrect

    • Which one of the following statements regarding pancreatic cancer is true?

      Your Answer: Radiotherapy is the mainstay of treatment for patients who are not suitable for surgery

      Correct Answer: High-resolution CT scanning is the diagnostic investigation of choice

      Explanation:

      Pancreatic cancer is best diagnosed through high-resolution CT scanning. Although chronic pancreatitis increases the risk, neither alcohol nor gallstone disease are significant independent risk factors. Radiotherapy is not effective for surgical resection. Unfortunately, most patients are diagnosed with unresectable lesions.

      Understanding Pancreatic Cancer: Risk Factors, Symptoms, and Management

      Pancreatic cancer is a type of cancer that is often diagnosed late due to its non-specific symptoms. Adenocarcinomas, which occur at the head of the pancreas, make up over 80% of pancreatic tumors. Risk factors for pancreatic cancer include increasing age, smoking, diabetes, chronic pancreatitis, hereditary non-polyposis colorectal carcinoma, and genetic mutations such as BRCA2 and KRAS.

      Symptoms of pancreatic cancer can include painless jaundice, pale stools, dark urine, pruritus, anorexia, weight loss, epigastric pain, loss of exocrine and endocrine function, and atypical back pain. Migratory thrombophlebitis, also known as Trousseau sign, is more common in pancreatic cancer than in other cancers.

      Diagnosis of pancreatic cancer can be made through ultrasound or high-resolution CT scanning, which may show the double duct sign – simultaneous dilatation of the common bile and pancreatic ducts. However, less than 20% of patients are suitable for surgery at diagnosis. A Whipple’s resection, or pancreaticoduodenectomy, may be performed for resectable lesions in the head of the pancreas. Adjuvant chemotherapy is usually given following surgery, and ERCP with stenting may be used for palliation.

      In summary, pancreatic cancer is a serious disease with non-specific symptoms that can be difficult to diagnose. Understanding the risk factors and symptoms can help with early detection and management.

    • This question is part of the following fields:

      • Gastroenterology/Nutrition
      18.5
      Seconds
  • Question 8 - A 10-year-old child with a history of infective diarrhoea presents with fever, hypertension,...

    Correct

    • A 10-year-old child with a history of infective diarrhoea presents with fever, hypertension, haematuria and bloody stools two weeks later. What could be a potential diagnosis?

      Your Answer: Haemolytic uraemic syndrome

      Explanation:

      Haemolytic uraemic syndrome (HUS) is a condition that causes progressive kidney failure and is associated with microangiopathic haemolytic anaemia and thrombocytopenia. There are two main types of HUS, one of which is associated with Shiga-like toxin (Stx) and is commonly seen in children who have had diarrhoea. The classic form of Stx-HUS is often caused by E. coli O157:H7 and is characterized by a history of gastroenteritis, fever, bloody diarrhoea, oedema, and hypertension. Henoch-Schönlein purpura is an acute disorder that affects small blood vessels in various parts of the body, including the skin, gastrointestinal tract, kidneys, and joints. It is characterized by a rash with bullae and ulcers, which typically appears in crops. Post-infectious glomerulonephritis is a condition that occurs after a streptococcal infection and is characterized by haematuria, proteinuria, red blood cell casts in the urine, oedema, and hypertension. Membranoproliferative glomerulonephritis is a rare cause of chronic nephritis that occurs primarily in children and young adults and may be idiopathic or secondary in aetiology. Acute interstitial nephritis is a condition that causes sudden kidney dysfunction, fever, and occasionally a rash, and is often associated with drug use.

    • This question is part of the following fields:

      • Renal Medicine/Urology
      16.9
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  • Question 9 - A 35-year-old woman comes to the GP clinic for preconception counseling. She plans...

    Incorrect

    • A 35-year-old woman comes to the GP clinic for preconception counseling. She plans to conceive within the next 6 months. She has never been pregnant before and has a medical history of Type 1 diabetes mellitus and irritable bowel syndrome. She is currently taking insulin and has no known drug allergies. Her BMI is 22 kg/m2, and she does not smoke or drink alcohol. There is no family history of neural tube defects, and her partner has no history of neural tube defects. What is the recommended folic acid dosage for her?

      Your Answer: Folic acid 400 micrograms once a day from now to 12 weeks of pregnancy

      Correct Answer: Folic acid 5 mg once a day from now to 12 weeks of pregnancy

      Explanation:

      If a woman has Type 1 diabetes mellitus, she is at a high risk of having a baby with neural tube defects. To prevent this, she should take 5mg of folic acid daily for three months before getting pregnant until the first 12 weeks of pregnancy. Any other dosage or duration of the regime would be incorrect for her.

      Folic Acid: Importance, Deficiency, and Prevention

      Folic acid is a vital nutrient that is converted to tetrahydrofolate (THF) in the body. It is found in green, leafy vegetables and plays a crucial role in the transfer of 1-carbon units to essential substrates involved in the synthesis of DNA and RNA. However, certain factors such as phenytoin, methotrexate, pregnancy, and alcohol excess can cause a deficiency in folic acid. This deficiency can lead to macrocytic, megaloblastic anemia and neural tube defects.

      To prevent neural tube defects during pregnancy, it is recommended that all women take 400mcg of folic acid until the 12th week of pregnancy. Women at higher risk of conceiving a child with a neural tube defect should take 5mg of folic acid from before conception until the 12th week of pregnancy. Women are considered higher risk if they or their partner has a neural tube defect, they have had a previous pregnancy affected by a neural tube defect, or they have a family history of a neural tube defect. Additionally, women with certain medical conditions such as coeliac disease, diabetes, or thalassaemia trait, or those taking antiepileptic drugs, or who are obese (BMI of 30 kg/m2 or more) are also considered higher risk.

      In summary, folic acid is an essential nutrient that plays a crucial role in DNA and RNA synthesis. Deficiency in folic acid can lead to serious health consequences, including neural tube defects. However, taking folic acid supplements during pregnancy can prevent these defects and ensure a healthy pregnancy.

    • This question is part of the following fields:

      • Reproductive Medicine
      46.6
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  • Question 10 - An 80-year-old man arrives at the Emergency Department after slipping on ice and...

    Correct

    • An 80-year-old man arrives at the Emergency Department after slipping on ice and falling backwards, hitting his head on the kerb and landing on his right arm. He did not lose consciousness and is currently feeling fine. The patient has a medical history of atrial fibrillation and is taking bisoprolol and warfarin. His INR was 2.2 four days ago. There are no visible injuries to his arm or scalp. What is the best course of action for his head injury?

      Your Answer: Arrange a CT head scan to be performed within 8 hours

      Explanation:

      NICE Guidelines for Investigating Head Injuries in Adults

      Head injuries can be serious and require prompt medical attention. The National Institute for Health and Care Excellence (NICE) has provided clear guidelines for healthcare professionals to determine which adult patients need further investigation with a CT head scan. Patients who require immediate CT head scans include those with a Glasgow Coma Scale (GCS) score of less than 13 on initial assessment, suspected open or depressed skull fractures, signs of basal skull fractures, post-traumatic seizures, focal neurological deficits, and more than one episode of vomiting.

      For patients with any loss of consciousness or amnesia since the injury, a CT head scan within 8 hours is recommended for those who are 65 years or older, have a history of bleeding or clotting disorders, experienced a dangerous mechanism of injury, or have more than 30 minutes of retrograde amnesia of events immediately before the head injury. Additionally, patients on warfarin who have sustained a head injury with no other indications for a CT head scan should also receive a scan within 8 hours of the injury.

      It is important for healthcare professionals to follow these guidelines to ensure that patients receive appropriate and timely care for their head injuries. By identifying those who require further investigation, healthcare professionals can provide the necessary treatment and support to prevent further complications and improve patient outcomes.

    • This question is part of the following fields:

      • Neurology
      26.7
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  • Question 11 - A mother brings her 8-month-old son to your clinic with concerns about his...

    Incorrect

    • A mother brings her 8-month-old son to your clinic with concerns about his left eye. She reports that his left eye is constantly watering and occasionally becomes sticky, but there is no yellow or green discharge. The child has been treated twice with chloramphenicol drops, but there was no improvement. A negative eye swab was obtained last month. The child is healthy and has no issues with visual development. What would be your approach to managing this patient?

      Your Answer: Routine ophthalmology referral

      Correct Answer: Reassurance and advice to continue conservative treatment unless symptoms persist beyond 1 year of age

      Explanation:

      Recurrent watery or sticky eyes in neonates may be caused by congenital tear duct obstruction, which typically resolves on its own by the age of 1. This condition can often be mistaken for conjunctivitis, leading to multiple appointments and unsuccessful treatment with chloramphenicol drops and negative swabs. Parents should be reassured that most cases will resolve on their own, but if symptoms persist beyond 1 year, a referral to an ophthalmologist is recommended.

      Understanding Nasolacrimal Duct Obstruction in Infants

      Nasolacrimal duct obstruction is a common condition that affects around 10% of infants at one month of age. It is characterized by a persistent watery eye caused by an imperforate membrane, usually located at the lower end of the lacrimal duct. Fortunately, symptoms usually resolve on their own by the age of one year in 95% of cases.

      To manage this condition, parents can be taught to massage the lacrimal duct to help clear any blockages. However, if symptoms persist beyond one year, it is recommended to seek the advice of an ophthalmologist. In such cases, probing may be considered, which is a procedure done under a light general anaesthetic. By understanding the causes and management of nasolacrimal duct obstruction, parents can take the necessary steps to ensure their child’s eye health and comfort.

    • This question is part of the following fields:

      • Ophthalmology
      43.4
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  • Question 12 - A 25-year-old woman who is 14 weeks pregnant complains of worsening acne that...

    Incorrect

    • A 25-year-old woman who is 14 weeks pregnant complains of worsening acne that is causing her distress. Despite using topical benzyl peroxide, she has noticed limited improvement. During examination, non-inflammatory lesions and pustules are observed on her face. What would be the most suitable next course of action?

      Your Answer: Oral trimethoprim

      Correct Answer: Oral erythromycin

      Explanation:

      If treatment for acne is required during pregnancy, oral erythromycin is a suitable option, as the other medications are not recommended.

      Acne vulgaris is a common skin condition that typically affects adolescents, with the face, neck, and upper trunk being the most commonly affected areas. It is characterized by the obstruction of hair follicles with keratin plugs, leading to the formation of comedones, inflammation, and pustules. The severity of acne can be classified as mild, moderate, or severe, depending on the presence and extent of inflammatory lesions, papules, and pustules.

      The management of acne vulgaris typically involves a step-up approach, starting with single topical therapy such as topical retinoids or benzoyl peroxide. If this is not effective, topical combination therapy may be used, which includes a topical antibiotic, benzoyl peroxide, and topical retinoid. Oral antibiotics such as tetracyclines may also be prescribed, but they should be avoided in pregnant or breastfeeding women and children under 12 years of age. Erythromycin may be used in pregnancy, while minocycline is now considered less appropriate due to the possibility of irreversible pigmentation. Oral antibiotics should be used for a maximum of three months and always co-prescribed with a topical retinoid or benzoyl peroxide to reduce the risk of antibiotic resistance.

      Combined oral contraceptives (COCP) are an alternative to oral antibiotics in women, and Dianette (co-cyrindiol) may be used as it has anti-androgen properties. However, it has an increased risk of venous thromboembolism compared to other COCPs, so it should generally be used second-line and for only three months. Oral isotretinoin is a potent medication that should only be used under specialist supervision, and it is contraindicated in pregnancy. Finally, there is no evidence to support dietary modification in the management of acne vulgaris.

    • This question is part of the following fields:

      • Dermatology
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  • Question 13 - Which one of the following statements regarding endometriosis is false? ...

    Correct

    • Which one of the following statements regarding endometriosis is false?

      Your Answer: Laparoscopic findings correlate well with the severity of symptoms and can guide treatment

      Explanation:

      Understanding Endometriosis

      Endometriosis is a common condition where endometrial tissue grows outside of the uterus. It affects around 10% of women of reproductive age and can cause chronic pelvic pain, painful periods, painful intercourse, and subfertility. Other symptoms may include urinary problems and painful bowel movements. Diagnosis is typically made through laparoscopy, and treatment options depend on the severity of symptoms.

      First-line treatments for symptomatic relief include NSAIDs and/or paracetamol. If these do not help, hormonal treatments such as the combined oral contraceptive pill or progestogens may be tried. If symptoms persist or fertility is a priority, referral to secondary care may be necessary. Secondary treatments may include GnRH analogues or surgery. For women trying to conceive, laparoscopic excision or ablation of endometriosis plus adhesiolysis is recommended, as well as ovarian cystectomy for endometriomas.

      It is important to note that there is poor correlation between laparoscopic findings and severity of symptoms, and that there is little role for investigation in primary care. If symptoms are significant, referral for a definitive diagnosis is recommended.

    • This question is part of the following fields:

      • Reproductive Medicine
      18.8
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  • Question 14 - A 50-year-old male is taking oral antibiotics for mild diverticulitis. He goes to...

    Correct

    • A 50-year-old male is taking oral antibiotics for mild diverticulitis. He goes to a wedding and later complains of palpitations, vomiting, headache, and flushing. His heart rate is 110 beats/min. He has no significant medical history and no known allergies to any medication or food. He denies using recreational drugs but admits to having one beer at the wedding. What antibiotic is he likely taking?

      Your Answer: Metronidazole

      Explanation:

      When metronidazole and ethanol are taken together, it can result in a disulfiram-like reaction, which can cause symptoms such as flushing in the head and neck, nausea, vomiting, sweating, headaches, and palpitations. Additionally, alcohol consumption should be avoided when taking cefoperazone, a cephalosporin, as it can also lead to a disulfiram-like reaction.

      Metronidazole is an antibiotic that functions by producing reactive cytotoxic metabolites within bacteria. This medication can cause adverse effects such as a disulfiram-like reaction when combined with alcohol and an increased anticoagulant effect when taken with warfarin.

    • This question is part of the following fields:

      • Infectious Diseases
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  • Question 15 - You see a 61-year-old man with backache.
    Which ONE of the following may indicate...

    Correct

    • You see a 61-year-old man with backache.
      Which ONE of the following may indicate a potentially serious pathology and hence requires referral as an emergency?

      Your Answer: Perineal anaesthesia

      Explanation:

      Back pain can have various causes, some of which may require urgent medical attention. Perineal anaesthesia, which involves numbness in the perineal, buttock, and inner thigh areas, is a red flag for back pain and may indicate cauda equina syndrome. This condition involves compression or damage to the tail of the spinal cord and requires urgent magnetic resonance imaging (MRI) for diagnosis. Other symptoms of cauda equina syndrome include severe or progressive back pain, new urinary or fecal incontinence, and lower limb weakness. Unilateral leg pain that is worse than low back pain may suggest sciatica, which can be managed conservatively without red flags. Pain radiating to the buttock on one side may also indicate nerve root irritation and can be managed in primary care if there are no red flags. However, new back pain in patients under 20 or over 55 years old should be taken seriously and may require urgent referral for further investigation. Localized neurological signs may indicate nerve root irritation, but do not necessarily require emergency referral. Red flags for back pain, such as constant, non-mechanical pain, thoracic pain, past history of malignant tumor, prolonged use of corticosteroids, and unexplained weight loss, require thorough work-up and consideration of imaging and specialist referral.

    • This question is part of the following fields:

      • Neurology
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  • Question 16 - A 50-year-old female with a history of Sjogren's syndrome presents to the gastroenterology...

    Correct

    • A 50-year-old female with a history of Sjogren's syndrome presents to the gastroenterology clinic with elevated liver function tests. She reports experiencing fatigue and itching that has worsened over the past 3 months. On physical examination, her abdomen is soft, nontender, and without any organ enlargement. Laboratory results show a low hemoglobin level, normal platelet count and white blood cell count, elevated bilirubin, alkaline phosphatase, and gamma-glutamyl transferase levels, and positive anti-mitochondrial antibodies. What is the initial treatment recommended to halt the progression of her liver disease?

      Your Answer: Ursodeoxycholic acid

      Explanation:

      Primary biliary cholangitis is a chronic liver disease that primarily affects middle-aged women. It is characterized by the destruction of small bile ducts in the liver, leading to cholestasis and liver damage. The disease is diagnosed through blood tests that measure levels of specific antibodies and liver enzymes, which are highly specific to the condition. Ursodeoxycholic acid is the preferred treatment for slowing disease progression and improving symptoms, while cholestyramine can be used to alleviate itching but does not affect disease progression. In cases of decompensated liver disease, such as when bilirubin levels exceed 100, liver transplantation may be an option. Although recurrence in the graft can occur, it is typically not a significant issue. While fat-soluble vitamins can be supplemented, they are not a primary treatment option.

      Primary Biliary Cholangitis: A Chronic Liver Disorder

      Primary biliary cholangitis, previously known as primary biliary cirrhosis, is a chronic liver disorder that is commonly observed in middle-aged women. The exact cause of this condition is not yet fully understood, but it is believed to be an autoimmune disease. The disease is characterized by the progressive damage of interlobular bile ducts due to chronic inflammation, leading to cholestasis and eventually cirrhosis. The most common symptom of primary biliary cholangitis is itching in middle-aged women.

      This condition is often associated with other autoimmune diseases such as Sjogren’s syndrome, rheumatoid arthritis, systemic sclerosis, and thyroid disease. Early symptoms of primary biliary cholangitis may be asymptomatic or may include fatigue, pruritus, and cholestatic jaundice. Late symptoms may progress to liver failure. Diagnosis of primary biliary cholangitis involves immunology tests such as anti-mitochondrial antibodies (AMA) M2 subtype and smooth muscle antibodies, as well as imaging tests to exclude an extrahepatic biliary obstruction.

      The first-line treatment for primary biliary cholangitis is ursodeoxycholic acid, which slows down the progression of the disease and improves symptoms. Cholestyramine is used to alleviate pruritus, and fat-soluble vitamin supplementation is recommended. In severe cases, liver transplantation may be necessary, especially if bilirubin levels exceed 100. However, recurrence in the graft can occur, but it is not usually a problem. Complications of primary biliary cholangitis include cirrhosis, portal hypertension, ascites, variceal hemorrhage, osteomalacia, osteoporosis, and an increased risk of hepatocellular carcinoma.

    • This question is part of the following fields:

      • Gastroenterology/Nutrition
      40.2
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  • Question 17 - A 24-year-old man with a history of recurrent otitis media, two bouts of...

    Correct

    • A 24-year-old man with a history of recurrent otitis media, two bouts of pneumonia, and a recent Giardia infection suffered a severe allergic reaction to a blood transfusion after a road traffic accident. His investigations showed slightly decreased immunoglobulins, a mild obstructive pattern on spirometry, and normal values for haemoglobin, white cell count, and platelets. What is the most likely diagnosis for this patient?

      Your Answer: Immunoglobulin A (IgA) deficiency

      Explanation:

      Understanding Immunoglobulin Deficiencies and Their Symptoms

      Immunoglobulin deficiencies are a group of disorders that affect the body’s ability to produce specific types of antibodies, leading to an increased risk of infections and autoimmune diseases. Here, we will discuss the different types of immunoglobulin deficiencies and their associated symptoms.

      IgA Deficiency:
      This deficiency is characterized by a decrease in immunoglobulin A, which can lead to an increased incidence of mucosal infections, particularly gastrointestinal infections with Giardia. Patients may also experience recurrent ear infections, sinusitis, bronchitis, pneumonia, and urinary tract infections. Additionally, IgA deficiency increases the risk of autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus.

      IgE Deficiency:
      IgE is responsible for fighting parasitic and helminthic infections, so patients with IgE deficiency are more likely to develop these types of infections. They are also at an increased risk of autoimmune disease and non-allergic reactive airways disease.

      IgG Deficiency:
      Patients with IgG deficiency are prone to developing infections from encapsulated bacteria, such as Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis. This deficiency can lead to upper and lower respiratory tract infections and meningitis.

      IgM Deficiency:
      Primary selective IgM deficiency results in increased infections by bacteria, fungi, and viruses, as well as increased autoimmune diseases. However, this deficiency does not have the selectivity for mucosal membrane infections seen in IgA deficiency.

      Severe Combined Immunoglobulin Deficiency (SCID):
      SCID is a rare disorder that results from abnormal T- and B-cell development due to inherited genetic mutations. Patients with SCID are affected early in life with multiple severe bacterial, viral, and fungal infections, as well as failure to thrive, interstitial lung disease, and chronic diarrhea.

      In conclusion, understanding the different types of immunoglobulin deficiencies and their associated symptoms is crucial for prompt recognition and treatment of opportunistic bacterial infections and autoimmune diseases.

    • This question is part of the following fields:

      • Immunology/Allergy
      69.7
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  • Question 18 - Which one of the following statements regarding the HPV vaccine is incorrect? ...

    Incorrect

    • Which one of the following statements regarding the HPV vaccine is incorrect?

      Your Answer: The second dose is given at 3-4 years

      Correct Answer: Children who received another live vaccine 2 weeks ago can safely have MMR

      Explanation:

      The MMR Vaccine: Information on Contraindications and Adverse Effects

      The Measles, Mumps and Rubella (MMR) vaccine is given to children in the UK twice before they enter primary school. The first dose is administered at 12-15 months, while the second dose is given at 3-4 years old. This vaccine is part of the routine immunisation schedule.

      However, there are certain contraindications to the MMR vaccine. Children with severe immunosuppression, allergies to neomycin, or those who have received another live vaccine by injection within four weeks should not receive the MMR vaccine. Pregnant women should also avoid getting vaccinated for at least one month following the MMR vaccine. Additionally, if a child has undergone immunoglobulin therapy within the past three months, there may be no immune response to the measles vaccine if antibodies are present.

      While the MMR vaccine is generally safe, there are some adverse effects that may occur. After the first dose of the vaccine, some children may experience malaise, fever, and rash. These symptoms typically occur after 5-10 days and last for around 2-3 days. It is important to be aware of these potential side effects and to consult with a healthcare professional if any concerns arise.

    • This question is part of the following fields:

      • Paediatrics
      38.3
      Seconds
  • Question 19 - A 60-year-old man complains of worsening pain and swelling in both knees with...

    Correct

    • A 60-year-old man complains of worsening pain and swelling in both knees with stiffness and decreased mobility over the past eight months. He also has painful wrist joints with nodules at the proximal and distal interphalangeal joints which have developed slowly over the past two years.
      Which of the following is the most likely diagnosis?

      Your Answer: Osteoarthritis (OA)

      Explanation:

      Differentiating between types of arthritis: A case study

      In this case study, a patient presents with bony swelling at the DIP and PIP joints of the hands. It is important to differentiate between various types of arthritis to make an accurate diagnosis and provide appropriate treatment.

      Osteoarthritis (OA) is characterized by loss of articular cartilage and overgrowth of underlying bone, commonly affecting the hips, knees, and small hand joints. Pain and swelling are common presenting features, along with crepitus on examination. Heberden’s and Bouchard’s nodes may also be present.

      Osteoporosis, on the other hand, is a condition of reduced bone density and increased fragility, often diagnosed following a low-impact fracture or screening of high-risk patients. Pain and bony swelling are not typical features of osteoporosis.

      Psoriatic arthritis is an inflammatory seronegative spondyloarthropathy associated with psoriasis, commonly affecting the hands but not causing the changes described in this case. Dactylitis is a usual examination finding with psoriatic arthritis.

      Reactive arthritis is characterized by a triad of urethritis, conjunctivitis, and arthritis following an infection. It typically presents as an acute, asymmetrical lower-limb arthritis, occurring a few days to weeks after the initial infection.

      Rheumatoid arthritis (RA) presents most often in women between the ages of 35 and 55 with symmetrical polyarticular arthritis, most often in the small joints of the hands or feet. Swelling is present at the metacarpophalangeal and PIP joints of the hands, along with other signs such as swan neck and Boutonnière deformities of the fingers, ulnar deviation of fingers, and Z deformity of the thumb.

      In conclusion, careful examination and consideration of various types of arthritis are necessary for an accurate diagnosis and appropriate treatment plan.

    • This question is part of the following fields:

      • Musculoskeletal
      30.1
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  • Question 20 - A 67-year-old man presents to the memory clinic with a history of cognitive...

    Correct

    • A 67-year-old man presents to the memory clinic with a history of cognitive decline over the past 10 months. His wife reports that he is struggling with basic tasks and becoming increasingly forgetful and confused. She has also noticed a change in his personality, including more frequent swearing and inappropriate behavior such as answering the door naked. Interestingly, his mother had a similar reputation in her later years. The patient reports smoking 20 cigarettes per day and drinking one glass of wine each evening. What is the most probable diagnosis?

      Your Answer: Frontotemporal dementia

      Explanation:

      The patient is likely suffering from frontotemporal dementia, which is also known as Pick’s disease. This type of dementia is characterized by a change in personality and social disinhibition, and it often has a positive family history. In contrast, Alzheimer’s disease typically presents with a decline in episodic memory and visuospatial awareness, while Lewy body dementia is characterized by fluctuating confusion and hallucinations. Creutzfeldt-Jakob disease is a rare condition that causes rapid neurodegeneration and may present with cognitive decline and personality changes, as well as additional symptoms such as abnormal movements and loss of coordination.

      Understanding Frontotemporal Lobar Degeneration

      Frontotemporal lobar degeneration (FTLD) is a type of cortical dementia that is the third most common after Alzheimer’s and Lewy body dementia. There are three recognized types of FTLD: Frontotemporal dementia (Pick’s disease), Progressive non-fluent aphasia (chronic progressive aphasia, CPA), and Semantic dementia. Common features of frontotemporal lobar dementias include onset before 65, insidious onset, relatively preserved memory and visuospatial skills, personality change, and social conduct problems.

      Pick’s disease is the most common type of FTLD and is characterized by personality change and impaired social conduct. Other common features include hyperorality, disinhibition, increased appetite, and perseveration behaviors. Focal gyral atrophy with a knife-blade appearance is characteristic of Pick’s disease. Macroscopic changes seen in Pick’s disease include atrophy of the frontal and temporal lobes. Microscopic changes include Pick bodies, spherical aggregations of tau protein (silver-staining), gliosis, neurofibrillary tangles, and senile plaques.

      In contrast, CPA is characterized by non-fluent speech, with short utterances that are agrammatic. Comprehension is relatively preserved. Semantic dementia, on the other hand, is characterized by fluent progressive aphasia. The speech is fluent but empty and conveys little meaning. Unlike in Alzheimer’s, memory is better for recent rather than remote events.

      In terms of management, NICE does not recommend the use of AChE inhibitors or memantine in people with frontotemporal dementia. Understanding the different types of FTLD and their characteristics can aid in early diagnosis and appropriate management.

    • This question is part of the following fields:

      • Neurology
      32.9
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  • Question 21 - A 65-year-old man comes to the General Practitioner with his daughter. She reports...

    Incorrect

    • A 65-year-old man comes to the General Practitioner with his daughter. She reports that her father’s behavior has changed over the past year. He used to be a very sociable and outgoing man but recently he has become withdrawn and uninterested in his hobbies. He has also become forgetful and has difficulty completing tasks that he used to do easily. The patient tells you that he does not think there is anything wrong with him and he is just getting older.
      Which of the following is the most likely diagnosis?

      Your Answer: Alzheimer’s disease

      Correct Answer: Frontotemporal dementia

      Explanation:

      Differentiating Types of Dementia: A Brief Overview

      Dementia is a broad term used to describe a decline in cognitive function that interferes with daily activities. However, there are different types of dementia, each with unique characteristics. Here are some key features to help differentiate between frontotemporal dementia, Alzheimer’s disease, Huntington’s disease, normal-pressure hydrocephalus (NPH), and Parkinson’s disease.

      Frontotemporal Dementia
      This type of dementia is rare and typically affects individuals between the ages of 55 and 65. Early personality and behavior changes are core symptoms, while memory impairment is not typical. Other key features include a gradual progression, decline in social conduct, emotional blunting, and loss of insight.

      Alzheimer’s Disease
      Alzheimer’s disease is the most common form of dementia, affecting individuals over the age of 65. Memory loss is a key early symptom, followed by agitation and obsessive behavior later in the disease course.

      Huntington’s Disease
      Huntington’s disease is a neurodegenerative condition that is often inherited. Symptoms include memory impairment, depression, clumsiness, mood swings, and difficulty concentrating. However, this patient’s symptoms are more consistent with early frontotemporal dementia.

      Normal-Pressure Hydrocephalus (NPH)
      NPH is a reversible cause of dementia characterized by gait abnormality, memory impairment, and incontinence. It may be mistaken for Parkinson’s disease, but symptoms will not improve with levodopa.

      Parkinson’s Disease
      While dementia and hallucinations may develop during the course of Parkinson’s disease, it is primarily a movement disorder characterized by tremors, rigidity, and bradykinesia.

    • This question is part of the following fields:

      • Neurology
      43.1
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  • Question 22 - A 10-year-old boy presents to the General Practitioner with his father who reports...

    Incorrect

    • A 10-year-old boy presents to the General Practitioner with his father who reports that he has been falling behind at school. His teachers have noticed that multiple times during lessons he appears to be 'staring into space' for about ten seconds at a time, during which there is twitching of his arms. He does not remember these episodes. He is referred for an electroencephalography (EEG) which shows spike-and-wave complexes during an episode. He is started on a new medication.
      Which of the following is the most likely treatment?

      Your Answer: Lamotrigine

      Correct Answer: Ethosuximide

      Explanation:

      When it comes to treating absence seizures, ethosuximide is the preferred first-line option for women and girls who may become pregnant. Boys and men can be treated with either ethosuximide or sodium valproate. Absence seizures are most common in children and young people, and are characterized by brief episodes of fixed gaze and possible arm or leg movements. An EEG can confirm the presence of spike-and-wave complexes during an attack. Sodium valproate may be used for boys and men, but should be avoided in women of childbearing potential due to the risk of birth defects. Carbamazepine is not effective for absence seizures, but is the first-line treatment for focal seizures. Lamotrigine may be used as a second-line option if other treatments are not effective or well-tolerated. In cases of status epilepticus, intravenous lorazepam is the preferred treatment in a hospital setting, but buccal midazolam or rectal diazepam can be used if intravenous access is not available.

    • This question is part of the following fields:

      • Neurology
      38.7
      Seconds
  • Question 23 - A 35-year-old man with a history of asthma and bipolar disorder visits his...

    Correct

    • A 35-year-old man with a history of asthma and bipolar disorder visits his local GP clinic complaining of 'tonsillitis' and requesting an antibiotic. Upon examination, he has inflamed tonsils on both sides, a temperature of 37.8ÂşC, and a pulse rate of 90/min. He is currently taking salbutamol inhaler as needed, Clenil inhaler 2 puffs twice daily, co-codamol 30/500 2 tablets four times a day, and quetiapine 100mg twice daily. The decision is made to prescribe penicillin. What is the most appropriate next step?

      Your Answer: Arrange a full blood count

      Explanation:

      Monitoring FBC is crucial in patients taking clozapine as agranulocytosis/neutropenia, a potentially fatal side effect, can occur. It is imperative to rule out neutropenia in case of infections.

      Atypical antipsychotics are now recommended as the first-line treatment for patients with schizophrenia, as per the 2005 NICE guidelines. These medications have the advantage of significantly reducing extrapyramidal side-effects. However, they can also cause adverse effects such as weight gain, hyperprolactinaemia, and in the case of clozapine, agranulocytosis. The Medicines and Healthcare products Regulatory Agency has issued warnings about the increased risk of stroke and venous thromboembolism when antipsychotics are used in elderly patients. Examples of atypical antipsychotics include clozapine, olanzapine, risperidone, quetiapine, amisulpride, and aripiprazole.

      Clozapine, one of the first atypical antipsychotics, carries a significant risk of agranulocytosis and requires full blood count monitoring during treatment. Therefore, it should only be used in patients who are resistant to other antipsychotic medication. The BNF recommends introducing clozapine if schizophrenia is not controlled despite the sequential use of two or more antipsychotic drugs, one of which should be a second-generation antipsychotic drug, each for at least 6-8 weeks. Adverse effects of clozapine include agranulocytosis, neutropaenia, reduced seizure threshold, constipation, myocarditis, and hypersalivation. Dose adjustment of clozapine may be necessary if smoking is started or stopped during treatment.

    • This question is part of the following fields:

      • Psychiatry
      86.5
      Seconds
  • Question 24 - A 42-year-old man has been receiving weekly intramuscular injections for rheumatoid arthritis for...

    Incorrect

    • A 42-year-old man has been receiving weekly intramuscular injections for rheumatoid arthritis for the past 8 weeks. Routine urinalysis shows that he has a proteinuria.
      Which of the following is he most likely to have been prescribed?

      Your Answer: Celecoxib

      Correct Answer: Gold

      Explanation:

      Rheumatoid arthritis can be treated with various drugs, including gold, infliximab, d-penicillamine, leflunomide, and celecoxib. Gold is given by injection and can cause side effects such as glomerulonephritis. Infliximab is administered intravenously and can lead to infections and autoimmune syndromes. D-penicillamine can cause proteinuria and is taken orally. Leflunomide blocks T cell expansion and can cause diarrhea, nausea, and abnormal blood test results. Celecoxib is an NSAID taken orally and can increase the risk of vascular events and gastrointestinal issues. Understanding the different drug categories and their side effects is important for effective treatment of rheumatoid arthritis. Monitoring for side effects is necessary for all disease-modifying drugs.

    • This question is part of the following fields:

      • Musculoskeletal
      44.2
      Seconds
  • Question 25 - A 35-year-old woman presents to the Emergency Department with a gradual decrease in...

    Incorrect

    • A 35-year-old woman presents to the Emergency Department with a gradual decrease in the hearing from her right ear. On further questioning, she reports that occasionally she hears a buzzing sound in this ear, but denies any episodes of dizziness or vomiting. Otoscopy of her right ear only reveals a reddish tympanic membrane. Rinne’s test is negative on the right, Weber’s test lateralises to the right. Which of the following describes the best management option for this condition?

      Your Answer: Amoxicillin 7-day course

      Correct Answer: Hearing aid

      Explanation:

      The best option for managing the patient’s unilateral conductive hearing loss, tinnitus, and pinkish tympanic membrane is either a hearing aid or stapedectomy. The tuning fork tests indicate left-sided conductive hearing loss, which is consistent with otosclerosis. This condition is characterized by the replacement of normal bone with vascular spongy bone, leading to progressive conductive hearing loss due to stapes fixation at the oval window. Amoxicillin, betahistine and vestibular rehabilitation exercises, ear syringing, and prochlorperazine are not effective treatments for otosclerosis. Amoxicillin is used to manage acute otitis media, betahistine and vestibular rehabilitation exercises are used to prevent acute attacks in MĂ©nière’s disease, ear syringing is used to remove impacted ear wax, and prochlorperazine is used to decrease dizziness in viral labyrinthitis.

    • This question is part of the following fields:

      • ENT
      81.8
      Seconds
  • Question 26 - A 28-year-old patient complains of a painful bump on their eyelid. The lump...

    Correct

    • A 28-year-old patient complains of a painful bump on their eyelid. The lump has been there for about four days and is gradually getting bigger.

      During the examination, a tender, smooth lump is observed, measuring roughly 2 mm in size, emerging from the outer edge of the left upper eyelid. The eye is not inflamed, and there is no periorbital or orbital redness, and the patient's visual acuity is normal.

      What is the best course of action for managing this condition?

      Your Answer: Provide advice on application of hot compresses and simple analgesia

      Explanation:

      Management of Stye or Hordeolum

      A stye or hordeolum is an acute and painful swelling of the eyelid caused by inflammation in an eyelash follicle. It usually presents unilaterally and can take a few days to develop. While it does not affect visual acuity, it can cause watery eyes. The first-line management for a stye is the application of warm compresses a few times a day, which can help the stye resolve or drain. However, if symptoms do not improve, referral to Eye Casualty for incision and drainage may be necessary. Topical antibiotics are not recommended in the absence of conjunctivitis, and systemic antibiotics are not indicated unless there are signs of cellulitis over the eyelid. Therefore, simple analgesia and warm compresses are the recommended management for a stye or hordeolum.

    • This question is part of the following fields:

      • Ophthalmology
      33
      Seconds
  • Question 27 - A 25-year-old woman with a history of type 1 diabetes mellitus presents at...

    Correct

    • A 25-year-old woman with a history of type 1 diabetes mellitus presents at the emergency department complaining of vomiting and abdominal pain. Upon examination, she appears dehydrated. The following are some of her blood test results:
      pH 7.23 (7.35-7.45)
      pCO2 2.1 kPa (4.5-6.0)
      pO2 11.2 kPa (10-14)
      Na+ 135 mmol/L (135-145)
      K+ 3.1 mmol/L (3.5-5.0)
      Bicarbonate 13 mmol/L (22-28)
      Glucose 22.4 mmol/L (<11.1)
      Ketones 3.6 mmol/L (<0.6)

      Question: What should be done with her regular insulin during her treatment?

      Your Answer: Continue long-acting insulin and stop short-acting insulin

      Explanation:

      In the management of DKA, it is important to continue the patient’s regular long-acting insulin while stopping their short-acting insulin. Fixed-rate insulin and fluids should also be administered. Continuing short-acting insulin may lead to hypoglycaemia, so it should be stopped until the patient is stable. Increasing the dose of both long-acting and short-acting insulin is not recommended.

      Diabetic ketoacidosis (DKA) is a serious complication of type 1 diabetes mellitus, accounting for around 6% of cases. It can also occur in rare cases of extreme stress in patients with type 2 diabetes mellitus. However, mortality rates have decreased from 8% to under 1% in the past 20 years. DKA is caused by uncontrolled lipolysis, resulting in an excess of free fatty acids that are ultimately converted to ketone bodies. The most common precipitating factors of DKA are infection, missed insulin doses, and myocardial infarction. Symptoms include abdominal pain, polyuria, polydipsia, dehydration, Kussmaul respiration, and acetone-smelling breath. Diagnostic criteria include glucose levels above 13.8 mmol/l, pH below 7.30, serum bicarbonate below 18 mmol/l, anion gap above 10, and ketonaemia.

      Management of DKA involves fluid replacement, insulin, and correction of electrolyte disturbance. Most patients with DKA are depleted around 5-8 litres, and isotonic saline is used initially, even if the patient is severely acidotic. Insulin is administered through an intravenous infusion, and correction of electrolyte disturbance is necessary. Long-acting insulin should be continued, while short-acting insulin should be stopped. DKA resolution is defined as pH above 7.3, blood ketones below 0.6 mmol/L, and bicarbonate above 15.0mmol/L. Complications may occur from DKA itself or the treatment, such as gastric stasis, thromboembolism, arrhythmias, acute respiratory distress syndrome, acute kidney injury, and cerebral oedema. Children and young adults are particularly vulnerable to cerebral oedema following fluid resuscitation in DKA and often need 1:1 nursing to monitor neuro-observations.

    • This question is part of the following fields:

      • Endocrinology/Metabolic Disease
      34.3
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  • Question 28 - What is the recommended next step in managing the blood pressure of a...

    Correct

    • What is the recommended next step in managing the blood pressure of a 42 year old woman with a history of depression and a recent paracetamol overdose who has a manual blood pressure reading of 165/85 mmHg?

      Your Answer: Offer ambulatory blood pressure monitoring

      Explanation:

      The National Institute for Clinical Excellence updated its guideline for hypertension management in 2011, placing emphasis on the use of ambulatory blood pressure monitoring (ABPM) to confirm hypertension in individuals with elevated clinic readings. ABPM involves taking two measurements per hour during waking hours and using the average of at least 14 measurements to confirm a diagnosis of hypertension. Secondary causes of hypertension should be investigated in patients under 40 without traditional risk factors, those with other symptoms of secondary causes, and those with resistant hypertension. Hyperaldosteronism is the most common cause of secondary hypertension, and a trial of spironolactone may be used for both therapeutic and diagnostic purposes. Drug treatment for essential hypertension involves ACE inhibitors for those under 55 and calcium channel blockers for those over 55 or of black African or Caribbean origin. Step 2 involves using both ACE inhibitors and calcium channel blockers, while step 3 adds a thiazide-like diuretic. Further diuretics, beta-blockers, or alpha blockers may be considered in step 4, with expert advice sought. For a more detailed explanation, refer to the provided link.

      NICE released updated guidelines in 2019 for the management of hypertension, building on previous guidelines from 2011. These guidelines aimed to classify hypertension into stages and recommend the use of ambulatory blood pressure monitoring (ABPM) and home blood pressure monitoring (HBPM) to accurately diagnose hypertension. This is important because some patients experience white coat hypertension, where their blood pressure rises in a clinical setting, leading to potential overdiagnosis of hypertension. ABPM and HBPM allow for a more accurate assessment of a patient’s overall blood pressure and can prevent overdiagnosis.

      NICE recommends measuring blood pressure in both arms when considering a diagnosis of hypertension and repeating measurements if there is a difference of more than 20 mmHg between arms. If the blood pressure is >= 140/90 mmHg, NICE suggests offering ABPM or HBPM to confirm the diagnosis. If the blood pressure is >= 180/120 mmHg, referral for specialist assessment is recommended if there are signs of retinal haemorrhage or papilloedema or life-threatening symptoms. If target organ damage is identified, antihypertensive drug treatment may be started immediately.

      ABPM involves taking at least 2 measurements per hour during the person’s usual waking hours and using the average value of at least 14 measurements. If ABPM is not tolerated, HBPM should be offered. HBPM involves taking two consecutive measurements at least 1 minute apart, twice daily for at least 4 days, and using the average value of all remaining measurements.

      Interpreting the results of ABPM/HBPM is important for determining treatment. If the average blood pressure is >= 135/85 mmHg (stage 1 hypertension), treatment may be considered for patients under 80 years of age with target organ damage, established cardiovascular disease, renal disease, diabetes, or a 10-year cardiovascular risk equivalent to 10% or greater. In 2019, NICE also recommended considering antihypertensive drug treatment for adults under 60 with stage 1 hypertension and an estimated 10-year risk below 10%. If the average blood pressure is >= 150/95 mmHg (stage 2 hypertension), drug treatment should be offered regardless of age.

    • This question is part of the following fields:

      • Cardiovascular
      36.4
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  • Question 29 - Which one of the following is not included in the core Adolescent Health...

    Correct

    • Which one of the following is not included in the core Adolescent Health Promotion Program as outlined in the National Service Framework for Children?

      Your Answer: 8-9 month surveillance review

      Explanation:

      The regular surveillance evaluations that were conducted at 8 months, 2 years, and 3-4 years have been discontinued. Nevertheless, if a child is considered to be in a vulnerable situation, it is recommended to conduct more frequent assessments.

      Child Health Surveillance in the UK

      Child health surveillance in the UK involves a series of checks and tests to ensure the well-being of children from before birth to pre-school age. During the antenatal period, healthcare professionals ensure that the baby is growing properly and check for any maternal infections that may affect the baby. An ultrasound scan is also performed to detect any fetal abnormalities, and blood tests are done to check for neural tube defects.

      After birth, a clinical examination of the newborn is conducted, and a hearing screening test is performed. The mother is given a Personal Child Health Record, which contains important information about the child’s health. Within the first month, a heel-prick test is done to check for hypothyroidism, PKU, metabolic diseases, cystic fibrosis, and medium-chain acyl Co-A dehydrogenase deficiency (MCADD). A midwife visit may also be conducted within the first four weeks.

      In the following months, health visitor input is provided, and a GP examination is done at 6-8 weeks. Routine immunisations are also given during this time. Ongoing monitoring of growth, vision, and hearing is conducted, and health professionals provide advice on immunisations, diet, and accident prevention.

      In pre-school, a national orthoptist-led programme for pre-school vision screening is set to be introduced. Overall, child health surveillance in the UK aims to ensure that children receive the necessary care and attention to promote their health and well-being.

    • This question is part of the following fields:

      • Paediatrics
      19.6
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  • Question 30 - A 62-year-old man is being evaluated for cognitive impairment with concerns about a...

    Correct

    • A 62-year-old man is being evaluated for cognitive impairment with concerns about a movement disorder. As part of his evaluation, he undergoes cross-sectional brain imaging and a dopamine Transporter Scan (DaTscan). The results show reduced dopaminergic activity in the substantia nigra bilaterally on the DaTscan and age-related changes on the MRI head. What is the most probable diagnosis?

      Your Answer: Parkinson’s disease

      Explanation:

      Differentiating Neurodegenerative Disorders: A Comparison of Parkinson’s Disease, Alzheimer’s Dementia, Frontotemporal Dementia, Huntington’s Disease, and Vascular Dementia

      Neurodegenerative disorders can be difficult to differentiate due to overlapping symptoms. Parkinson’s disease, for example, involves the death of neurones in the substantia nigra and is often confirmed through the use of DaTscan, which visualises dopamine transporter levels in the brain. Dementia is a common complication of Parkinson’s disease, affecting 20-40% of patients and causing cognitive, mood, and behavioural changes.

      Alzheimer’s dementia, on the other hand, is characterised by cortical atrophy visible on CT and MRI scans and is not typically associated with movement disorders. Frontotemporal dementia primarily affects behaviour and language and is also not typically associated with movement disorders.

      Huntington’s disease is another basal ganglia disorder, but it primarily involves cell loss in the striatum, leading to chorea – uncontrollable limb movements. CT and MRI scans can show loss of striatal volume in moderate-to-severe cases, but early scans may appear normal.

      Vascular dementia, the second most common cause of dementia after Alzheimer’s, often has a history of cerebral vascular disease and is not typically associated with movement disorders. Understanding the unique characteristics of each neurodegenerative disorder is crucial for accurate diagnosis and treatment.

    • This question is part of the following fields:

      • Neurology
      45.3
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SESSION STATS - PERFORMANCE PER SPECIALTY

Dermatology (0/2) 0%
Reproductive Medicine (2/3) 67%
Paediatrics (1/3) 33%
Ophthalmology (2/3) 67%
Neurology (5/7) 71%
Psychiatry (1/2) 50%
Gastroenterology/Nutrition (1/2) 50%
Renal Medicine/Urology (1/1) 100%
Infectious Diseases (1/1) 100%
Immunology/Allergy (1/1) 100%
Musculoskeletal (1/2) 50%
ENT (0/1) 0%
Endocrinology/Metabolic Disease (1/1) 100%
Cardiovascular (1/1) 100%
Passmed