MSFinals-1623
A 30-year-old obese woman presents with a gradual onset of hirsutism and abnormal menses. Her menses are irregular and vary in duration, timing and amount of bleeding. She had an impaired glucose tolerance diagnosis 2 years ago, using an oral glucose tolerance test. Luteinising hormone concentration is elevated. Serum androstenedione and testosterone concentrations are mildly elevated. Serum sex hormone-binding globulin is decreased. The concentration of 17-hydroxyprogesterone is normal. Ultrasound shows bilaterally enlarged ovaries with multiple cysts.
Which one of the following is the most likely diagnosis?