AKT-3578

A 65-year-old woman with longstanding rheumatoid arthritis presents with fatigue and loss of appetite of recent origin. Her serum creatinine is 230 µmol/l (50-120 µmol/l) and urea is 13.5 mmol/l (2.5-6.5 mmol/l). She has taken diclofenac for pain relief for several years.
Select from the list the single correct statement about this side-effect of diclofenac.