MRCP2-0062

MRCP2-0062

A 39-year-old woman with a diastolic murmur on auscultation is referred to the Cardiology Department by her GP. She denies any history of rheumatic fever and has lost 8 kg in weight over the last six months, with a couple of episodes of sudden fainting. On examination, she has finger clubbing and a diastolic murmur that varies greatly with her sitting forward and is associated with a friction rub. Investigations reveal a low haemoglobin level, high white cell count and platelet count, elevated ESR, and intracardiac calcification on CXR. Which diagnosis could account for all these findings?