MRCP2-2376

A 50-year-old man is referred by his GP to the haematology clinic with a four-week history of night sweats and early satiety. He reports feeling unwell for some time, but had attributed it to the added stress of his recent promotion as a managing director. On examination, there is a fullness in the left upper quadrant and widespread small volume lymphadenopathy. Blood tests reveal lymphocytosis with smudge cells and a bone marrow biopsy confirms diffuse growth pattern lymphocytosis. Chromosomal analysis is performed to guide further management. Which of the following findings on the analysis would suggest a poor prognosis?