MRCP2-3595

MRCP2-3595

A 65-year-old man is diagnosed with colorectal cancer and undergoes successful resection. However, after receiving six doses of adjuvant capecitabine, he experiences severe diarrhoea, weakness, and desquamation of the hands, feet, and face. He is admitted to the hospital with pancytopenia and electrolyte abnormalities requiring IV replacement. The following are his initial blood test results:

– Na+ 140 mmol/l
– K+ 3.6 mmol/l
– Urea 9.2 mmol/l
– Creatinine 125 µmol/l
– Hb 75 g/l
– Platelets 35 * 109/l
– WBC 0.4 * 109/l
– Neutrophils 0.03 * 109/l
– Adjusted Ca2+ 1.5 mmol/l
– Mg2+ 0.32 mmol/l
– Glucose 4.0 mmol/l

What is the most likely cause of his symptoms?