MS-0447

MS-0447

Mr. Johnson, a 68-year-old man visits his doctor with a complaint of experiencing dizzy spells for the past month. He mentions that he started taking a long-acting nitrate for heart failure about three weeks ago.

The doctor takes his sitting blood pressure and compares it to his previous readings.

Current BP 88/72mmHg
BP two months ago 130/90mmHg

The doctor concludes that the new medication has caused hypotension in Mr. Johnson.

What molecular mechanism could be responsible for this change in blood pressure?