MS-0493

A 48-year-old man comes to the clinic for a hypertension follow-up. He was diagnosed with high blood pressure two months ago and started on ramipril. However, his blood pressure remained uncontrolled, so amlodipine was added to his treatment four weeks ago. Today, his blood pressure reading is 161/91mmHg. You decide to prescribe indapamide, a thiazide diuretic. Can you identify the primary site of action of thiazides in the nephron?