MS-1013

MS-1013

Sarah is a 15-year-old female who presented to the clinic with concerns about her development. She has not grown as expected and remains shorter than most of the girls in her class. She also notes that she has not started her period yet, which is affecting her confidence.

On examination, she is 150cm tall and has no breast development. Pubic hair is sparse and axillary hair is absent. The uterus and ovaries are not palpable. A cleft palate is noted on examination of the mouth. When cranial nerve I was examined, she was unable to detect the smell of the odours sampled.

Blood tests show low levels of estrogen, follicular stimulating hormone (FSH) and luteinizing hormone (LH). Liver function tests were normal. Blood glucose reading was 5.6mmol/L. Iron studies were unremarkable.

What is the likely cause for her symptoms?