MS-1961

MS-1961

A 30-year-old female, Mrs Brown, visited the clinic due to a lump in her left breast. She did not experience any pain, fever or discharge. Her family has a significant history of cancer, with her sister passing away from a brain tumour at age 30 and her father being diagnosed with lung cancer at age 35. Mrs Brown is worried about the possibility of multiple tumours in her family and wishes to undergo further testing. Genetic testing confirmed that she has Li-Fraumeni syndrome. Which gene abnormality caused this syndrome?