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Question 1
Correct
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A woman attends at three weeks post-delivery with her baby for the general practitioner (GP)’s 3-week postnatal test. She had an elective Caesarean section for breech presentation and is currently breastfeeding.
Which of the following should be deferred until six weeks after delivery?Your Answer: Performing a smear test if this was delayed because of pregnancy
Explanation:Postnatal Check: What to Expect from Your GP
After giving birth, it is important to have a postnatal check with your GP to ensure that you are recovering well and to address any concerns you may have. Here are some of the things you can expect during your 6-week postnatal check:
Performing a Smear Test if Delayed Because of Pregnancy
If you were due for a routine smear test during pregnancy, it will be deferred until at least three months post-delivery. This is to avoid misinterpreting cell changes that occur during pregnancy and to identify any precancerous changes in the cells of the cervix.Assessment of Mood
Your GP will assess your mood and any psychological disturbance you may be experiencing. This is an opportunity to screen for postnatal depression and identify any need for additional support.Assessing Surgical Wound Healing and/or the Perineum if Required
Depending on the mode of delivery, your GP will assess the healing of any surgical wounds or perineal tears. They will also check for signs of infection or abnormal healing.Blood Pressure Reading
Your GP will perform a blood pressure reading, especially if you had hypertension during pregnancy. Urinalysis may also be performed if you had pre-eclampsia or signs of a urinary tract infection.Discussion of Contraceptive Options
Your GP will discuss family planning and the need for additional contraception, as required. This is important to prevent unintended pregnancies, especially if you are not exclusively breastfeeding.Overall, the 6-week postnatal check is an important part of your recovery process and ensures that you receive the necessary care and support during this time.
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This question is part of the following fields:
- Obstetrics
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Question 2
Correct
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A woman at 12 weeks gestation experiences a miscarriage. Out of these five factors, which one is most strongly linked to miscarriage?
Your Answer: Obesity
Explanation:Obesity is the only factor among the given options that has been linked to miscarriage. Other factors such as heavy lifting, bumping your tummy, having sex, air travel, and being stressed have not been associated with an increased risk of miscarriage. However, factors like increased maternal age, smoking in pregnancy, consuming alcohol, recreational drug use, high caffeine intake, infections and food poisoning, health conditions, and certain medicines have been linked to an increased risk of miscarriage. Additionally, an unusual shape or structure of the womb and cervical incompetence can also increase the risk of miscarriage.
Miscarriage: Understanding the Epidemiology
Miscarriage, also known as abortion, refers to the expulsion of the products of conception before 24 weeks. To avoid any confusion, the term miscarriage is often used. According to epidemiological studies, approximately 15-20% of diagnosed pregnancies will end in miscarriage during early pregnancy. In fact, up to 50% of conceptions may not develop into a blastocyst within 14 days.
Recurrent spontaneous miscarriage, which is defined as the loss of three or more consecutive pregnancies, affects approximately 1% of women. Understanding the epidemiology of miscarriage is important for healthcare providers and patients alike. It can help to identify risk factors and provide appropriate counseling and support for those who have experienced a miscarriage. By raising awareness and promoting education, we can work towards reducing the incidence of miscarriage and improving the overall health and well-being of women and their families.
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This question is part of the following fields:
- Obstetrics
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Question 3
Incorrect
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A 27-year-old G4P3 woman presents with a lump in the breast, having ceased breastfeeding her youngest child two weeks prior. Her past medical history is significant for previous episodes of mastitis when breastfeeding her older children. On examination the lump is in the right breast at the six o'clock position, 3 cm from the nipple. The lump is non-tender and the overlying skin seems unaffected. Her observations are as follows:
Heart rate: 90,
Respiratory rate: 14,
Blood pressure: 112/72 mmHg,
Oxygen saturation: 99%,
Temperature: 37.5 Cº.
What is the probable diagnosis, and what is the most appropriate next step in investigation?Your Answer: Galactocele, ultrasound imaging
Correct Answer: Galactocele, no further investigation necessary
Explanation:Galactocele and breast abscess can be distinguished based on clinical history and examination findings, without the need for further investigation.
Recent discontinuation of breastfeeding is a risk factor for both mastitis/abscess formation and galactocele formation. Galactoceles are distinguishable from breast abscesses because they are painless and non-tender upon examination, and there are no signs of infection locally or systemically.
Although the patient’s history of mastitis increases the likelihood of a breast abscess, the clinical presentation strongly suggests a galactocele (i.e. painless lump, no localized redness, and absence of fever).Understanding Galactocele
Galactocele is a condition that commonly affects women who have recently stopped breastfeeding. It occurs when a lactiferous duct becomes blocked, leading to the accumulation of milk and the formation of a cystic lesion in the breast. Unlike an abscess, galactocele is usually painless and does not cause any local or systemic signs of infection.
In simpler terms, galactocele is a type of breast cyst that develops when milk gets trapped in a duct. It is not a serious condition and can be easily diagnosed by a doctor. Women who experience galactocele may notice a lump in their breast, but it is usually painless and does not require any treatment. However, if the lump becomes painful or infected, medical attention may be necessary. Overall, galactocele is a common and harmless condition that can be managed with proper care and monitoring.
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This question is part of the following fields:
- Obstetrics
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Question 4
Correct
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As a result of her advanced maternal age, a 43-year-old pregnant woman undergoes screening for chromosomal abnormalities. If her fetus is diagnosed with trisomy 21 (Down's syndrome), what outcomes would be anticipated?
Your Answer: Low pregnancy-associated plasma protein A (PAPP-A)
Explanation:The ‘triple test’ can be utilized at 16 weeks, but its accuracy is lower than the ‘combined test’. Therefore, it should only be employed when screening for trisomy is conducted after 14 weeks. The test involves conducting blood tests for AFP, -HCG, and oestriol. One should note that the false positive rate may be higher with this test.
NICE updated guidelines on antenatal care in 2021, recommending the combined test for screening for Down’s syndrome between 11-13+6 weeks. The test includes nuchal translucency measurement, serum B-HCG, and pregnancy-associated plasma protein A (PAPP-A). The quadruple test is offered between 15-20 weeks for women who book later in pregnancy. Results are interpreted as either a ‘lower chance’ or ‘higher chance’ of chromosomal abnormalities. If a woman receives a ‘higher chance’ result, she may be offered a non-invasive prenatal screening test (NIPT) or a diagnostic test. NIPT analyzes cell-free fetal DNA in the mother’s blood and has high sensitivity and specificity for detecting chromosomal abnormalities. Private companies offer NIPT screening from 10 weeks gestation.
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This question is part of the following fields:
- Obstetrics
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Question 5
Correct
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A 33-week gestation woman presents for a follow-up ultrasound scan after her 20-week scan revealed a low-lying placenta. The repeat scan conducted in the department indicates that the placenta is partially covering the cervix's top. The obstetric consultant counsels her on the recommended mode of delivery. She has had four previous pregnancies, all of which she delivered vaginally, and has no medical or surgical history.
What is the appropriate recommendation that should be offered to her regarding the mode of delivery?Your Answer: Elective caesarean section at 37-38 weeks
Explanation:Women with grade III/IV placenta praevia should have an elective caesarean section at 37-38 weeks to prevent the risk of haemorrhage during vaginal delivery. Induction of labour and offering a caesarean section at 39-40 weeks are not recommended.
Management and Prognosis of Placenta Praevia
Placenta praevia is a condition where the placenta is located wholly or partially in the lower uterine segment. If a low-lying placenta is detected at the 20-week scan, a rescan is recommended at 32 weeks. There is no need to limit activity or intercourse unless there is bleeding. If the placenta is still present at 32 weeks and is grade I/II, then a scan every two weeks is recommended. A final ultrasound at 36-37 weeks is necessary to determine the method of delivery. For grades III/IV, an elective caesarean section is recommended between 37-38 weeks. However, if the placenta is grade I, a trial of vaginal delivery may be offered. If a woman with known placenta praevia goes into labour before the elective caesarean section, an emergency caesarean section should be performed due to the risk of post-partum haemorrhage.
In cases where placenta praevia is accompanied by bleeding, the woman should be admitted and an ABC approach should be taken to stabilise her. If stabilisation is not possible, an emergency caesarean section should be performed. If the woman is in labour or has reached term, an emergency caesarean section is also necessary.
The prognosis for placenta praevia has improved significantly, and death is now extremely rare. The major cause of death in women with placenta praevia is post-partum haemorrhage.
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This question is part of the following fields:
- Obstetrics
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Question 6
Correct
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A 20-year-old primigravida presents to your clinic with a complaint of persistent vomiting. She is currently 12 weeks pregnant and has been experiencing this symptom for the past four days. Upon examination, you note that she has a fast heart rate, low blood pressure upon standing, and her urine test shows the presence of ketones. What is the most significant risk factor for hyperemesis gravidarum?
Your Answer: Twin pregnancy
Explanation:Hyperemesis gravidarum, a severe form of nausea and vomiting in pregnancy, is associated with multiple pregnancies, molar pregnancies, young maternal age, first pregnancy, and obesity. The condition may be caused by high beta hCG and oestrogen levels, nutritional deficiencies, and gastric dysfunction due to high progesterone levels. Prolonged and frequent vomiting can be problematic.
Hyperemesis gravidarum is an extreme form of nausea and vomiting of pregnancy that occurs in around 1% of pregnancies and is most common between 8 and 12 weeks. It is associated with raised beta hCG levels and can be caused by multiple pregnancies, trophoblastic disease, hyperthyroidism, nulliparity, and obesity. Referral criteria for nausea and vomiting in pregnancy include continued symptoms with ketonuria and/or weight loss, a confirmed or suspected comorbidity, and inability to keep down liquids or oral antiemetics. The diagnosis of hyperemesis gravidarum requires the presence of 5% pre-pregnancy weight loss, dehydration, and electrolyte imbalance. Management includes first-line use of antihistamines and oral cyclizine or promethazine, with second-line options of ondansetron and metoclopramide. Admission may be needed for IV hydration. Complications can include Wernicke’s encephalopathy, Mallory-Weiss tear, central pontine myelinolysis, acute tubular necrosis, and fetal growth issues.
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This question is part of the following fields:
- Obstetrics
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Question 7
Correct
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You are evaluating a 23-year-old female who is 8 weeks pregnant and experiencing severe vomiting, making it difficult for her to retain fluids. What is the best method to determine the severity of her symptoms?
Your Answer: Pregnancy-Unique Quantification of Emesis (PUQE) scoring system
Explanation:Hyperemesis gravidarum is an extreme form of nausea and vomiting of pregnancy that occurs in around 1% of pregnancies and is most common between 8 and 12 weeks. It is associated with raised beta hCG levels and can be caused by multiple pregnancies, trophoblastic disease, hyperthyroidism, nulliparity, and obesity. Referral criteria for nausea and vomiting in pregnancy include continued symptoms with ketonuria and/or weight loss, a confirmed or suspected comorbidity, and inability to keep down liquids or oral antiemetics. The diagnosis of hyperemesis gravidarum requires the presence of 5% pre-pregnancy weight loss, dehydration, and electrolyte imbalance. Management includes first-line use of antihistamines and oral cyclizine or promethazine, with second-line options of ondansetron and metoclopramide. Admission may be needed for IV hydration. Complications can include Wernicke’s encephalopathy, Mallory-Weiss tear, central pontine myelinolysis, acute tubular necrosis, and fetal growth issues.
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This question is part of the following fields:
- Obstetrics
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Question 8
Correct
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A 32-year-old woman who is 13 weeks pregnant had pre-eclampsia in her previous pregnancy and underwent a caesarean section at 36 weeks gestation. Her blood pressure has been normal since then and today. What intervention should be suggested to decrease the likelihood of pre-eclampsia recurrence?
Your Answer: Low-dose aspirin
Explanation:Hypertension during pregnancy is a common occurrence that requires careful management. In normal pregnancies, blood pressure tends to decrease in the first trimester and then gradually increase to pre-pregnancy levels by term. However, in cases of hypertension during pregnancy, the systolic blood pressure is usually above 140 mmHg or the diastolic blood pressure is above 90 mmHg. Additionally, an increase of more than 30 mmHg systolic or 15 mmHg diastolic from the initial readings may also indicate hypertension.
There are three categories of hypertension during pregnancy: pre-existing hypertension, pregnancy-induced hypertension (PIH), and pre-eclampsia. Pre-existing hypertension refers to a history of hypertension before pregnancy or elevated blood pressure before 20 weeks gestation. PIH occurs in the second half of pregnancy and resolves after birth. Pre-eclampsia is characterized by hypertension and proteinuria, and may also involve edema.
The management of hypertension during pregnancy involves the use of antihypertensive medications such as labetalol, nifedipine, and hydralazine. In cases of pre-existing hypertension, ACE inhibitors and angiotensin II receptor blockers should be stopped immediately and alternative medications should be prescribed. Women who are at high risk of developing pre-eclampsia should take aspirin from 12 weeks until the birth of the baby. It is important to carefully monitor blood pressure and proteinuria levels during pregnancy to ensure the health of both the mother and the baby.
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This question is part of the following fields:
- Obstetrics
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Question 9
Correct
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A 32-year-old woman presents with vaginal bleeding at 34 weeks gestation (gravida 3, parity 2). The patient reports no abdominal pain but is worried about the possibility of a miscarriage. She has a history of two uncomplicated caesarean sections. What is the recommended first step in diagnosing her condition?
Your Answer: Transvaginal ultrasound
Explanation:Understanding Placenta Praevia
Placenta praevia is a condition where the placenta is located wholly or partially in the lower uterine segment. It is a relatively rare condition, with only 5% of women having a low-lying placenta when scanned at 16-20 weeks gestation. However, the incidence at delivery is only 0.5%, as most placentas tend to rise away from the cervix.
There are several factors associated with placenta praevia, including multiparity, multiple pregnancy, and embryos implanting on a lower segment scar from a previous caesarean section. Clinical features of placenta praevia include shock in proportion to visible loss, no pain, a non-tender uterus, abnormal lie and presentation, and a usually normal fetal heart. Coagulation problems are rare, and small bleeds may occur before larger ones.
Diagnosis of placenta praevia should not involve digital vaginal examination before an ultrasound, as this may provoke severe haemorrhage. The condition is often picked up on routine 20-week abdominal ultrasounds, but the Royal College of Obstetricians and Gynaecologists recommends the use of transvaginal ultrasound for improved accuracy and safety. Placenta praevia is classified into four grades, with grade IV being the most severe, where the placenta completely covers the internal os.
In summary, placenta praevia is a rare condition that can have serious consequences if not diagnosed and managed appropriately. It is important for healthcare professionals to be aware of the associated factors and clinical features, and to use appropriate diagnostic methods for accurate grading and management.
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This question is part of the following fields:
- Obstetrics
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Question 10
Incorrect
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A 40-year-old pregnant woman is confused about why she has been advised to undergo an oral glucose tolerance test. She has had four previous pregnancies, and her babies' birth weights have ranged from 3.4-4.6kg. She has no history of diabetes, but both her parents have hypertension, and her grandfather has diabetes. She is of white British ethnicity and has a BMI of 29.6kg/m². What is the reason for recommending an oral glucose tolerance test for this patient?
Your Answer: Her body mass index
Correct Answer: Previous macrosomia
Explanation:It is recommended that pregnant women with a family history of diabetes undergo an oral glucose tolerance test (OGTT) for gestational diabetes between 24 and 28 weeks of pregnancy.
Gestational diabetes is a common medical disorder affecting around 4% of pregnancies. Risk factors include a high BMI, previous gestational diabetes, and family history of diabetes. Screening is done through an oral glucose tolerance test, and diagnostic thresholds have recently been updated. Management includes self-monitoring of blood glucose, diet and exercise advice, and medication if necessary. For pre-existing diabetes, weight loss and insulin are recommended, and tight glycemic control is important. Targets for self-monitoring include fasting glucose of 5.3 mmol/l and 1-2 hour post-meal glucose levels.
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This question is part of the following fields:
- Obstetrics
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Question 11
Correct
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A 29-year-old woman on day one postpartum who is breastfeeding is concerned about the safety of her pain medication. When you arrive, you find that the patient was prescribed acetaminophen for pain relief, but when she was offered this, she told the midwife it cannot be used as it can have detrimental effects for her baby. She wants to know if there are any other options. You explain that acetaminophen is safe to use while breastfeeding. Which of the following analgesics is another safe first line treatment to use in women who are breastfeeding?
Your Answer: Paracetamol
Explanation:Safe Pain Relief Options for Breastfeeding Mothers: A Guide to Medications
Breastfeeding mothers often experience pain and discomfort, and it is important to know which pain relief options are safe to use while nursing. Paracetamol and ibuprofen are considered safe and can be used as first-line medication for analgesia. Codeine and other opiates can be used sparingly as third-line medication, but caution must be taken as some women may be slow metabolizers and it can cause drowsiness and respiratory depression in the infant. Aspirin is contraindicated due to the risk of Reye’s disease and other side-effects. Naproxen is generally safe, but paracetamol and ibuprofen should be the mainstay of analgesia. Tramadol can be used with caution and should be prescribed by a specialist. It is important to advise the woman on the safe use of medication and to monitor for any signs of toxicity in the infant.
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This question is part of the following fields:
- Obstetrics
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Question 12
Correct
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A 23-year-old primigravida comes for her first midwifery appointment at nine weeks’ gestation. She was born in Romania and is uncertain if she has received the MMR vaccine.
What is the indicative outcome for rubella immunity resulting from vaccination?Your Answer: Rubella IgM antibody negative, IgG antibody positive
Explanation:Understanding Rubella Antibody Results: IgM and IgG
Rubella, also known as German measles, is a viral infection that can cause serious complications for pregnant women and their babies. Testing for rubella antibodies can help determine if someone is immune to the virus or has recently been infected.
A negative result for rubella IgM antibodies indicates that there is no current or recent infection. However, a positive result for rubella IgG antibodies indicates that the person has either been vaccinated or previously infected with the virus, making them immune.
It is important for pregnant women to know their rubella antibody status, as contracting the virus during the first trimester can lead to miscarriage or congenital rubella syndrome in the baby. Women who are not immune to rubella are offered vaccination after pregnancy.
In summary, understanding rubella antibody results can help individuals and healthcare providers make informed decisions about vaccination and pregnancy planning.
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This question is part of the following fields:
- Obstetrics
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Question 13
Correct
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A 26-year-old woman with type 1 diabetes mellitus visits her General Practitioner (GP) with her partner to seek advice on nutritional supplementation as they plan to start trying for a baby. She is not using any contraception and her diabetes is well managed, with her latest HbA1c level at 32 mmol/mol (recommended by the Royal College of Obstetricians and Gynaecologists < 48 mmol/mol). What is the most suitable recommendation for folic acid supplementation?
Your Answer: Commence folic acid 5 mg daily now and continue until week 12 of gestation
Explanation:Folic Acid Supplementation in Pregnancy
Explanation: Folic acid supplementation is recommended for all women who are trying to conceive and during pregnancy to reduce the risk of neural tube defects and other congenital abnormalities. The recommended dose is 400 micrograms daily from the preconception period until the 12th week of gestation. However, women with certain high-risk factors, such as diabetes, a family history of neural tube defects, or obesity, are advised to take a higher dose of 5 mg daily from the preconception period until the 12th week of gestation. It is important to continue folic acid supplementation until the end of the first trimester to ensure proper formation of the brain and other major organs in the body. Side-effects of folic acid treatment may include abdominal distension, reduced appetite, nausea, and exacerbation of pernicious anaemia.
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This question is part of the following fields:
- Obstetrics
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Question 14
Incorrect
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A 28-year-old woman contacts her GP via telephone. She is currently 20 weeks pregnant and has had no complications thus far. However, she is now concerned as she recently spent time with her niece who has developed a rash that her sister suspects to be chickenpox. The patient is unsure if she had chickenpox as a child, but she had no symptoms until the past 24 hours when she developed a rash. She feels fine otherwise but is worried about the health of her baby. What is the most appropriate course of action at this point?
Your Answer: Varicella-zoster immunoglobulin
Correct Answer: Oral acyclovir
Explanation:When pregnant women who are at least 20 weeks along contract chickenpox, they are typically prescribed oral acyclovir if they seek treatment within 24 hours of the rash appearing. This is in accordance with RCOG guidelines and is an important topic for exams. If the patient is asymptomatic after being exposed to chickenpox and is unsure of their immunity, a blood test should be conducted urgently. If the test is negative, VZIG should be administered. However, if the patient is certain that they are not immune to chickenpox, VZIG should be given without the need for a blood test. It is incorrect to administer both VZIG and oral acyclovir once symptoms of chickenpox have appeared, as VZIG is no longer effective at that point. Intravenous acyclovir is only necessary in cases of severe chickenpox.
Chickenpox exposure in pregnancy can pose risks to both the mother and fetus, including fetal varicella syndrome. Post-exposure prophylaxis (PEP) with varicella-zoster immunoglobulin (VZIG) or antivirals should be given to non-immune pregnant women, with timing dependent on gestational age. If a pregnant woman develops chickenpox, specialist advice should be sought and oral acyclovir may be given if she is ≥ 20 weeks and presents within 24 hours of onset of the rash.
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This question is part of the following fields:
- Obstetrics
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Question 15
Correct
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A 34-year-old woman in her second pregnancy comes in at 11 weeks with a 1-day history of vaginal bleeding. Bleeding began as a light brown discharge while wiping and was accompanied by menstrual-like cramps. Symptoms have since subsided. During the examination, the abdomen is soft and painless, the cervical os is closed, and there is some dark brown discharge in the vaginal area.
What ultrasound results would confirm the diagnosis?Your Answer: Gestational sac seen within the uterus; fetal heart rate present
Explanation:Understanding Different Types of Miscarriage
Miscarriage is the loss of pregnancy before 20 weeks’ gestation and can occur due to various risk factors. There are different types of miscarriage, each with its own set of symptoms and ultrasound findings.
Threatened Miscarriage: This type presents with lower abdominal pain and light brown discharge. Ultrasound reveals an intrauterine gestational sac and fetal heart rate. Patients may experience further threatened miscarriage or proceed to a complete or full-term pregnancy.
Inevitable Miscarriage: Active bleeding within the uterine cavity is suggestive of an ongoing miscarriage. The cervical os is open, and products of conception may be seen within the vagina. This type will inevitably progress to a miscarriage.
Complete Miscarriage: An empty uterus is associated with a complete miscarriage. Examination reveals a closed cervical os and may or may not be associated with vaginal bleeding.
Missed Miscarriage: A gestational sac small for dates, associated with an absent fetal heart rate, is an incidental finding. Examination is unremarkable, with a closed cervical os and no evidence of vaginal bleeding.
Incomplete Miscarriage: Products of conception are seen within the uterus, with an absent fetal heart rate. Examination reveals an open or closed cervical os and bleeding. If this miscarriage does not proceed to a complete miscarriage, it will require surgical evacuation.
Understanding the different types of miscarriage can help patients and healthcare providers manage the condition effectively.
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This question is part of the following fields:
- Obstetrics
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Question 16
Correct
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A 30-year-old woman with a previous macrosomic baby and a history of gestational diabetes presents in her second pregnancy. She is at eight weeks’ gestation and attends the midwife booking visit.
What is the most suitable test to diagnose gestational diabetes in this patient?Your Answer: A 2-hour OGTT as soon as possible following the booking visit
Explanation:Gestational diabetes is a condition where pregnant women experience high blood sugar levels. It is diagnosed through a 2-hour oral glucose tolerance test (OGTT) between 24 and 28 weeks of pregnancy. Women with risk factors such as a BMI over 30, a previous macrosomic baby, a family history of diabetes, or from an area with high diabetes prevalence should be offered the test. Random serum glucose, fasting serum glucose, HbA1c, and urinalysis are not recommended for diagnosis. Gestational diabetes can have negative effects on both the mother and fetus, including fetal macrosomia, stillbirth, neonatal hypoglycemia, and an increased risk of type II diabetes and obesity in the baby’s later life. Women with pre-existing diabetes should have their HbA1c monitored monthly and at booking to assess pregnancy risk, but HbA1c is not used to diagnose gestational diabetes. Early detection and management of gestational diabetes is crucial to prevent complications.
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This question is part of the following fields:
- Obstetrics
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Question 17
Correct
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A 32-year-old woman who is P1 G2 is 30 minutes post-partum of an uncomplicated delivery. Suddenly, she starts gasping for breath and appears cyanosed with a blood pressure of 83/65 mmHg, heart rate of 120 bpm, and a respiratory rate of 33/min. She becomes unresponsive. What is the probable diagnosis?
Your Answer: Amniotic fluid embolism
Explanation:The symptoms and time frame mentioned in the question strongly suggest an amniotic fluid embolism, which typically occurs during or within 30 minutes of labor and is characterized by respiratory distress, hypoxia, and hypotension. On the other hand, intracranial hemorrhage is usually preceded by a severe headache, while convulsions are indicative of eclampsia and drug toxicity. The symptoms experienced by the patient during normal labor would not be expected in cases of drug toxicity. Additionally, hypoxia is not a typical symptom of drug toxicity.
Amniotic fluid embolism is a rare but serious complication of pregnancy that can result in a high mortality rate. It occurs when fetal cells or amniotic fluid enter the mother’s bloodstream, triggering a reaction that leads to various signs and symptoms. While several risk factors have been associated with this condition, such as maternal age and induction of labor, the exact cause remains unclear. It is believed that exposure of maternal circulation to fetal cells or amniotic fluid is necessary for the development of an amniotic fluid embolism, but the underlying pathology is not well understood.
The majority of cases of amniotic fluid embolism occur during labor, but they can also occur during a cesarean section or in the immediate postpartum period. Symptoms of this condition include chills, shivering, sweating, anxiety, and coughing, while signs may include cyanosis, hypotension, bronchospasms, tachycardia, arrhythmia, and myocardial infarction. Diagnosis is primarily clinical and based on exclusion, as there are no definitive diagnostic tests available.
Management of amniotic fluid embolism requires a multidisciplinary team and critical care unit. Treatment is mainly supportive, focusing on addressing the patient’s symptoms and stabilizing their condition. Given the high mortality rate associated with this condition, prompt recognition and management are crucial for improving outcomes.
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This question is part of the following fields:
- Obstetrics
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Question 18
Correct
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A 32-year-old pregnant woman presents to your clinic with concerns about her rubella status. Her sister's child has recently been diagnosed with rubella, and she is currently 10 weeks pregnant. What is the initial course of action you would recommend?
Your Answer: Discuss immediately with the local Health Protection Unit
Explanation:In case of suspected rubella during pregnancy, it is important to consult with the local Health Protection Unit for guidance on appropriate investigations to conduct. If the mother is found to be non-immune to rubella, the MMR vaccine should be administered after childbirth, although the risk of transmission to the fetus is uncertain. If transmission does occur, particularly during this stage of pregnancy, it can cause significant harm to the developing fetus. Hospitalization is not necessary at this point.
Rubella and Pregnancy: Risks, Features, Diagnosis, and Management
Rubella, also known as German measles, is a viral infection caused by the togavirus. Thanks to the introduction of the MMR vaccine, it is now rare. However, if contracted during pregnancy, there is a risk of congenital rubella syndrome, which can cause serious harm to the fetus. It is important to note that the incubation period is 14-21 days, and individuals are infectious from 7 days before symptoms appear to 4 days after the onset of the rash.
The risk of damage to the fetus is highest in the first 8-10 weeks of pregnancy, with a risk as high as 90%. However, damage is rare after 16 weeks. Features of congenital rubella syndrome include sensorineural deafness, congenital cataracts, congenital heart disease (e.g. patent ductus arteriosus), growth retardation, hepatosplenomegaly, purpuric skin lesions, ‘salt and pepper’ chorioretinitis, microphthalmia, and cerebral palsy.
If a suspected case of rubella in pregnancy arises, it should be discussed immediately with the local Health Protection Unit (HPU) as type/timing of investigations may vary. IgM antibodies are raised in women recently exposed to the virus. It should be noted that it is very difficult to distinguish rubella from parvovirus B19 clinically. Therefore, it is important to also check parvovirus B19 serology as there is a 30% risk of transplacental infection, with a 5-10% risk of fetal loss.
If a woman is tested at any point and no immunity is demonstrated, they should be advised to keep away from people who might have rubella. Non-immune mothers should be offered the MMR vaccination in the post-natal period. However, MMR vaccines should not be administered to women known to be pregnant or attempting to become pregnant.
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This question is part of the following fields:
- Obstetrics
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Question 19
Incorrect
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A 29-year-old female attends the antenatal clinic for a booking appointment. What should be recognized as a risk factor for pre-eclampsia?
Your Answer: History of smoking
Correct Answer: Pre-existing renal disease
Explanation:Identify the following as potential risk factors:
– Being 40 years old or older
– Never having given birth
– Having a pregnancy interval of over 10 years
– Having a family history of pre-eclampsia
– Having previously experienced pre-eclampsia
– Having a body mass index (BMI) of 30 kg/m^2 or higher
– Having pre-existing vascular disease, such as hypertension.Pre-eclampsia is a condition that occurs during pregnancy and is characterized by high blood pressure, proteinuria, and edema. It can lead to complications such as eclampsia, neurological issues, fetal growth problems, liver involvement, and cardiac failure. Severe pre-eclampsia is marked by hypertension, proteinuria, headache, visual disturbances, and other symptoms. Risk factors for pre-eclampsia include hypertension in a previous pregnancy, chronic kidney disease, autoimmune disease, diabetes, chronic hypertension, first pregnancy, and age over 40. Aspirin may be recommended for women with high or moderate risk factors. Treatment involves emergency assessment, admission for observation, and medication such as labetalol, nifedipine, or hydralazine. Delivery of the baby is the most important step in management, with timing depending on the individual case.
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This question is part of the following fields:
- Obstetrics
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Question 20
Correct
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A 32-year-old female who is 20 weeks pregnant has a raised serum alpha-fetoprotein (AFP) and is worried about the possible causes. What could be responsible for the elevated AFP levels in this patient?
Your Answer: Omphalocele
Explanation:A raised level of maternal serum AFP is linked to fetal abdominal wall defects such as omphalocele. Conversely, low levels of maternal AFP are associated with Down’s syndrome, maternal diabetes mellitus, Edwards syndrome, and maternal obesity.
Alpha-fetoprotein (AFP) is a protein that is created by the fetus during development. When there is an increase in AFP levels, it may indicate the presence of certain conditions such as neural tube defects (meningocele, myelomeningocele and anencephaly), abdominal wall defects (omphalocele and gastroschisis), multiple pregnancy, Down’s syndrome, trisomy 18, and maternal diabetes mellitus. On the other hand, a decrease in AFP levels may also be significant and should be further investigated.
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This question is part of the following fields:
- Obstetrics
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Question 21
Correct
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A 28-year-old woman with type 1 diabetes mellitus, well controlled on insulin, attends the Fetal Medicine Clinic for a growth scan at 36 weeks. The scan has been unremarkable, and the consultant will discuss the mode and timing of delivery today. The baby is cephalic, and the placenta is posterior and high.
Which of the following statements regarding the mode and timing of delivery in patients with diabetes is correct?Your Answer: Women with gestational diabetes should give birth no later than 40+6 weeks’ gestation
Explanation:Managing Delivery in Women with Diabetes during Pregnancy
Women with diabetes during pregnancy require special attention during delivery to ensure the safety of both the mother and the baby. Here are some important considerations:
Delivery should not be delayed beyond 40+6 weeks’ gestation to avoid the risk of stillbirth.
Delivery before 37 weeks is not recommended unless there are metabolic or other maternal or fetal complications.
Vaginal delivery is not recommended in the presence of a macrosomic fetus, but the woman should be informed of the risks and make an informed decision.
Induction or elective Caesarean section should be considered between 37+0 and 38+6 weeks’ gestation to minimize the risk of stillbirth and fetal macrosomia.
Women with a previous Caesarean section can opt for vaginal birth after Caesarean section (VBAC) if the indication for the previous Caesarean section is not recurring.
During delivery, intrapartum glucose levels should be monitored closely, and appropriate interventions should be taken to maintain glucose levels between 4 and 7 mmol/l.
By following these guidelines, healthcare providers can ensure a safe delivery for women with diabetes during pregnancy.
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This question is part of the following fields:
- Obstetrics
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Question 22
Incorrect
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A 28-year-old primigravida arrives at 39 weeks with ruptured membranes and bleeding. She reports a rush of cloudy fluid followed by persistent vaginal bleeding. Despite feeling anxious, she denies experiencing any localized pain or tenderness. Although her pregnancy has been uneventful, she has not attended her prenatal scans. The cardiotocography reveals late decelerations and bradycardia. What is the probable diagnosis?
Your Answer: Placenta praevia
Correct Answer: Vasa praevia
Explanation:Vasa praevia is a complication where the blood vessels of the fetus are located near or cross the internal opening of the uterus. If the supporting membranes rupture, the vessels can easily be damaged, resulting in bleeding. The classic symptoms of vasa praevia include painless vaginal bleeding and fetal bradycardia following the rupture of membranes. While there is no significant risk to the mother, fetal mortality rates are high. It can be challenging to differentiate vasa praevia from placenta praevia in emergency situations, but a preceding rupture of membranes is usually highlighted in exams. Although ultrasound scans can identify vasa praevia, some cases may go undetected during pregnancy.
Understanding Bleeding During Pregnancy
Bleeding during pregnancy can be a cause for concern and should be promptly evaluated by a healthcare professional. There are various causes of bleeding during pregnancy, which can be categorized based on the trimester in which they occur. In the first trimester, the major causes of bleeding include spontaneous abortion, ectopic pregnancy, and hydatidiform mole. In the second trimester, bleeding may be due to spontaneous abortion, hydatidiform mole, or placental abruption. In the third trimester, bleeding may be caused by placental abruption, placenta praevia, or vasa praevia.
It is important to note that conditions such as sexually transmitted infections and cervical polyps should also be ruled out as potential causes of bleeding during pregnancy. Each condition has its own unique features that can help in diagnosis. For instance, spontaneous abortion may present as threatened miscarriage, missed miscarriage, or inevitable miscarriage, depending on the extent of fetal and placental tissue expulsion. Ectopic pregnancy is typically characterized by lower abdominal pain and vaginal bleeding, while hydatidiform mole may present with exaggerated pregnancy symptoms and high serum hCG levels.
Placental abruption is usually accompanied by constant lower abdominal pain and a tender, tense uterus, while placenta praevia may present with painless vaginal bleeding and an abnormal lie and presentation. Vasa praevia is characterized by rupture of membranes followed immediately by vaginal bleeding and fetal bradycardia.
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This question is part of the following fields:
- Obstetrics
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Question 23
Correct
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A 38-year-old G7P3 mother presents with a show and waters breaking at 34+1 weeks, following three days of fever and left flank pain. Despite hoping for a home birth, she eventually agrees to go to the hospital after three hours of convincing from the midwife. Upon arrival, continuous cardiotocography is initiated and a foetal doppler reveals foetal bradycardia. On abdominal exam, the baby is found to be in a footling breech position, but the uterus is non-tender and contracting. A speculum examination reveals an exposed cord, with a soft 8 cm cervix and an exposed left foot.
What is the most appropriate initial management plan for this patient and her baby?Your Answer: Put the patient on all fours and push the foot back into the uterus
Explanation:In the case of umbilical cord prolapse, the priority is to limit compression on the cord and reduce the chance of cord vasospasm. This can be achieved by pushing any presenting part of the baby back into the uterus, putting the mother on all fours, and retrofilling the bladder with saline. In addition, warm damp towels can be placed over the cord to limit handling. It is important to note that this is a complex emergency that requires immediate attention, as it can lead to foetal bradycardia and limit the oxygen supply to the baby. In this scenario, a category 1 Caesarean section would be necessary, as the pathological CTG demands it. Delivering the baby as breech immediately is not recommended, as it is a high-risk strategy that can lead to morbidity and mortality. IM corticosteroids are indicated for premature rupture of membranes, but the immediate priority is to deal with the emergency. McRobert’s manoeuvre is not appropriate in this case, as it is used to correct shoulder dystocia, which is not the issue at hand.
Understanding Umbilical Cord Prolapse
Umbilical cord prolapse is a rare but serious complication that can occur during delivery. It happens when the umbilical cord descends ahead of the presenting part of the fetus, which can lead to compression or spasm of the cord. This can cause fetal hypoxia and potentially irreversible damage or death. Certain factors increase the risk of cord prolapse, such as prematurity, multiparity, polyhydramnios, twin pregnancy, cephalopelvic disproportion, and abnormal presentations like breech or transverse lie.
Around half of all cord prolapses occur when the membranes are artificially ruptured. Diagnosis is usually made when the fetal heart rate becomes abnormal and the cord is palpable vaginally or visible beyond the introitus. Cord prolapse is an obstetric emergency that requires immediate management. The presenting part of the fetus may be pushed back into the uterus to avoid compression, and the cord should be kept warm and moist to prevent vasospasm. The patient may be asked to go on all fours or assume the left lateral position until preparations for an immediate caesarian section have been carried out. Tocolytics may be used to reduce uterine contractions, and retrofilling the bladder with saline can help elevate the presenting part. Although caesarian section is the usual first-line method of delivery, an instrumental vaginal delivery may be possible if the cervix is fully dilated and the head is low.
In conclusion, umbilical cord prolapse is a rare but serious complication that requires prompt recognition and management. Understanding the risk factors and appropriate interventions can help reduce the incidence of fetal mortality associated with this condition.
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This question is part of the following fields:
- Obstetrics
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Question 24
Incorrect
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As the obstetrics FY2 doctor, you are reviewing the labour ward patient list. What discovery in one of the patients, who is slightly older, would prompt you to initiate continuous CTG monitoring during labour?
Your Answer: Blood pressure of 140/90 mmHg
Correct Answer: New onset vaginal bleed while in labour
Explanation:Continuous CTG monitoring is recommended during labour if any of the following conditions are present or develop: suspected chorioamnionitis or sepsis, a temperature of 38°C or higher, severe hypertension with a reading of 160/110 mmHg or above, use of oxytocin, or significant meconium. In addition, the 2014 update to the guidelines added fresh vaginal bleeding as a new point of concern, as it may indicate placental rupture or placenta previa, both of which require monitoring of the baby.
Cardiotocography (CTG) is a medical procedure that measures pressure changes in the uterus using either internal or external pressure transducers. It is used to monitor the fetal heart rate, which normally ranges between 100-160 beats per minute. There are several features that can be observed during a CTG, including baseline bradycardia (heart rate below 100 beats per minute), which can be caused by increased fetal vagal tone or maternal beta-blocker use. Baseline tachycardia (heart rate above 160 beats per minute) can be caused by maternal pyrexia, chorioamnionitis, hypoxia, or prematurity. Loss of baseline variability (less than 5 beats per minute) can be caused by prematurity or hypoxia. Early deceleration, which is a decrease in heart rate that starts with the onset of a contraction and returns to normal after the contraction, is usually harmless and indicates head compression. Late deceleration, on the other hand, is a decrease in heart rate that lags behind the onset of a contraction and does not return to normal until after 30 seconds following the end of the contraction. This can indicate fetal distress, such as asphyxia or placental insufficiency. Variable decelerations, which are independent of contractions, may indicate cord compression.
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This question is part of the following fields:
- Obstetrics
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Question 25
Correct
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In the Obstetric Outpatient Department, a patient with a history of hypertension and a BMI of 17 comes to you with concerns about pre-eclampsia. She is 28 years old, in her second pregnancy with the same partner, and has a four-year-old child. She has heard about pre-eclampsia from her friends and is worried about her risk. Which factor in her history is a risk factor for pre-eclampsia?
Your Answer: Known hypertension
Explanation:Risk Factors for Pre-eclampsia in Pregnancy
Pre-eclampsia is a serious disorder of pregnancy that can lead to life-threatening complications if left untreated. It is important to identify risk factors for pre-eclampsia in order to provide appropriate monitoring and care for pregnant women.
Known hypertension is a significant risk factor for pre-eclampsia. Women with hypertension should be closely monitored throughout their pregnancy.
Age is also a factor, with women over 40 being at increased risk. However, the patient in this scenario is 28 years old and not at increased risk.
First pregnancy or first pregnancy with a new partner is a risk factor for pre-eclampsia. However, as this is the patient’s second pregnancy with the same partner, she is not at increased risk.
A high BMI is a risk factor for pre-eclampsia, particularly if a patient’s BMI is over 35. However, a low BMI, such as the patient’s BMI of 17, is not a risk factor.
Finally, a period of ten years or more since the last pregnancy is a moderate risk factor for pre-eclampsia. As the patient has a child that is four years old, she is not at increased risk.
In conclusion, identifying and monitoring risk factors for pre-eclampsia is crucial in ensuring the health and safety of pregnant women and their babies.
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This question is part of the following fields:
- Obstetrics
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Question 26
Correct
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You are asked to review a 32-year-old woman, who is breastfeeding on day two post-emergency Caesarean section, because her wound is tender. On examination, you notice that the skin surrounding the wound is erythematosus, with a small amount of yellow discharge. There is no wound dehiscence. The area is tender on examination. Observations are stable, and the patient is apyrexial. You send a swab from the wound for culture. She has an allergy to penicillin.
Which of the following is the best next step in this patient’s management?Your Answer: Oral erythromycin
Explanation:Treatment of Cellulitis in Post-Caesarean Section Patient
Cellulitis around the Caesarean wound site requires prompt treatment to prevent the development of sepsis, especially in postpartum women. The initial steps include wound swab for culture and sensitivities, marking the area of cellulitis, and analgesia. Flucloxacillin is the first-line antibiotic for cellulitis, but oral erythromycin is recommended for patients with penicillin allergy. The dose of erythromycin is 500 mg four times a day orally for five to seven days, and it is safe during breastfeeding. Topical treatment is not as effective as systemic treatment, and analgesia is necessary to manage pain. Antibiotics should not be delayed until culture sensitivities are available, and intravenous antibiotics are not indicated unless the patient’s condition deteriorates. Close monitoring of symptoms, observations, and inflammatory markers should guide treatment.
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This question is part of the following fields:
- Obstetrics
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Question 27
Correct
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A 16-year-old female who is 23 weeks pregnant (G1PO) arrives at the emergency department complaining of severe lower abdominal pain. She has a history of multiple sexual partners and was recently treated for gonorrhoeae with ceftriaxone. Although she does not take any regular medications, she admits to using illicit drugs such as marijuana and cocaine. During the physical examination, you notice that her uterus is hard and tender. What risk factor in her medical history is likely to contribute to her diagnosis?
Your Answer: Cocaine use
Explanation:The risk of placental abruption is increased by cocaine abuse due to its ability to cause vasospasm in the placental blood vessels. Ceftriaxone use, which is the treatment of choice for gonorrhoeae, is not a known risk factor for placental abruption and is therefore a distractor. Although gonorrhoeae can lead to chorioamnionitis, which is a known risk factor for placental abruption, there is no evidence to suggest that this is the case and it is less likely than cocaine use. Primiparity is an incorrect answer as it is actually multiparity that is a risk factor for placental abruption.
Placental Abruption: Causes, Symptoms, and Risk Factors
Placental abruption is a condition that occurs when the placenta separates from the uterine wall, leading to maternal bleeding into the space between them. Although the exact cause of this condition is unknown, certain factors have been associated with it, including proteinuric hypertension, cocaine use, multiparity, maternal trauma, and increasing maternal age. Placental abruption is not a common occurrence, affecting approximately 1 in 200 pregnancies.
The clinical features of placental abruption include shock that is disproportionate to the visible blood loss, constant pain, a tender and tense uterus, and a normal lie and presentation of the fetus. The fetal heart may be absent or distressed, and there may be coagulation problems. It is important to be aware of other conditions that may present with similar symptoms, such as pre-eclampsia, disseminated intravascular coagulation (DIC), and anuria.
In summary, placental abruption is a serious condition that can have significant consequences for both the mother and the fetus. Understanding the risk factors and symptoms of this condition is important for early detection and appropriate management.
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This question is part of the following fields:
- Obstetrics
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Question 28
Correct
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A 30-year-old G1P0 woman in her 12th week of pregnancy presents to the emergency department with severe nausea and vomiting that has been worsening over the past week. She reports difficulty keeping any food down over the past 24 hours and noticed a small amount of fresh blood in her vomit. She denies any abdominal pain or change in bowel habits. Despite using cyclizine tablets, her symptoms have not improved. The patient has no significant medical history.
The following blood tests were taken and revealed abnormal results: Na+ 140 mmol/l (reference range 135-145 mmol/l), K+ 3.3 mmol/l (reference range 3.5-5.0 mmol/l), Cl- 100 mmol/l (reference range 95-105 mmol/l), HCO3- 23 mmol/l (reference range 22-28 mmol/l), urea 13 mmol/l (reference range 2.0-7.0 mmol/l), creatinine 80 mmol/l (reference range 55-120 umol/l), and blood glucose 6.0 mmol/l (reference range 4.0-7.8 mmol/l). A urine dipstick revealed 4+ ketonuria but no white or red cells.
What is the most appropriate course of action for this patient?Your Answer: Admit for IV fluid and electrolyte replacement, anti-emetics and trial of bland diet
Explanation:In cases where pregnant women experience severe nausea and vomiting leading to ketonuria and dehydration, admission to the hospital should be considered. This is especially true if they have already tried oral anti-emetics without success. Such symptoms are indicative of hyperemesis gravidarum, which can be confirmed by urine dipstick and increased blood urea levels. While pyridoxine is not recommended by the Royal College of Obstetricians and Gynaecologists (RCOG), ondansetron is effective as a second-line option. However, inpatient treatment is necessary. Gastroscopy is unlikely to be helpful at this stage, even if there is a small amount of blood in the vomit, which is likely due to a Mallory-Weiss tear caused by constant retching. Low K+ levels due to vomiting need to be replaced, and anti-emetics are necessary. Therefore, admission to the hospital for IV fluids, anti-emetics, and a trial of a bland diet is the appropriate course of action.
Hyperemesis gravidarum is an extreme form of nausea and vomiting of pregnancy that occurs in around 1% of pregnancies and is most common between 8 and 12 weeks. It is associated with raised beta hCG levels and can be caused by multiple pregnancies, trophoblastic disease, hyperthyroidism, nulliparity, and obesity. Referral criteria for nausea and vomiting in pregnancy include continued symptoms with ketonuria and/or weight loss, a confirmed or suspected comorbidity, and inability to keep down liquids or oral antiemetics. The diagnosis of hyperemesis gravidarum requires the presence of 5% pre-pregnancy weight loss, dehydration, and electrolyte imbalance. Management includes first-line use of antihistamines and oral cyclizine or promethazine, with second-line options of ondansetron and metoclopramide. Admission may be needed for IV hydration. Complications can include Wernicke’s encephalopathy, Mallory-Weiss tear, central pontine myelinolysis, acute tubular necrosis, and fetal growth issues.
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This question is part of the following fields:
- Obstetrics
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Question 29
Incorrect
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A 28-year-old woman is diagnosed with hypertension during her first prenatal visit at 12 weeks with a blood pressure reading of 150/100 mmHg. Her urine test reveals +++ protein. What is the best course of action to manage her hypertension?
Your Answer: Administer aspirin and intramuscular steroids
Correct Answer:
Explanation:Hypertension during pregnancy is a common occurrence that requires careful management. In normal pregnancies, blood pressure tends to decrease in the first trimester and then gradually increase to pre-pregnancy levels by term. However, in cases of hypertension during pregnancy, the systolic blood pressure is usually above 140 mmHg or the diastolic blood pressure is above 90 mmHg. Additionally, an increase of more than 30 mmHg systolic or 15 mmHg diastolic from the initial readings may also indicate hypertension.
There are three categories of hypertension during pregnancy: pre-existing hypertension, pregnancy-induced hypertension (PIH), and pre-eclampsia. Pre-existing hypertension refers to a history of hypertension before pregnancy or elevated blood pressure before 20 weeks gestation. PIH occurs in the second half of pregnancy and resolves after birth. Pre-eclampsia is characterized by hypertension and proteinuria, and may also involve edema.
The management of hypertension during pregnancy involves the use of antihypertensive medications such as labetalol, nifedipine, and hydralazine. In cases of pre-existing hypertension, ACE inhibitors and angiotensin II receptor blockers should be stopped immediately and alternative medications should be prescribed. Women who are at high risk of developing pre-eclampsia should take aspirin from 12 weeks until the birth of the baby. It is important to carefully monitor blood pressure and proteinuria levels during pregnancy to ensure the health of both the mother and the baby.
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This question is part of the following fields:
- Obstetrics
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Question 30
Incorrect
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A 35-year-old primigravida presents for her 9-week antenatal appointment. She recently had a private ultrasound which revealed dichorionic, diamniotic twins. The patient has a medical history of hypothyroidism and a BMI of 38 kg/m². Although she has been smoking during her pregnancy, she has reduced her intake from 20 to 5 cigarettes per day and is interested in trying nicotine replacement therapy. Her main concern is that both her mother and sister suffered from hyperemesis gravidarum. What factor in her history is linked to a lower likelihood of developing this condition?
Your Answer: Twin pregnancy
Correct Answer: Smoking
Explanation:Smoking has been found to decrease the risk of hyperemesis gravidarum, which is believed to occur due to rapidly rising levels of human chorionic gonadotropin (HCG) and oestrogen. This is because smoking is considered to be anti-oestrogenic. Therefore, despite having other risk factors, the fact that the patient is a smoker may decrease her incidence of hyperemesis gravidarum. On the other hand, hypothyroidism is not a risk factor, but hyperthyroidism increases the risk of hyperemesis gravidarum. Obesity and underweight are associated with an increased risk of hyperemesis, but women with these conditions who smoked before pregnancy have been found to have no increased risk. Primigravida status is also associated with an increased risk of hyperemesis, but the reason for this is not clear. Finally, twin pregnancies carry an increased risk of hyperemesis gravidarum due to higher levels of beta-hCG released from the placenta.
Hyperemesis gravidarum is an extreme form of nausea and vomiting of pregnancy that occurs in around 1% of pregnancies and is most common between 8 and 12 weeks. It is associated with raised beta hCG levels and can be caused by multiple pregnancies, trophoblastic disease, hyperthyroidism, nulliparity, and obesity. Referral criteria for nausea and vomiting in pregnancy include continued symptoms with ketonuria and/or weight loss, a confirmed or suspected comorbidity, and inability to keep down liquids or oral antiemetics. The diagnosis of hyperemesis gravidarum requires the presence of 5% pre-pregnancy weight loss, dehydration, and electrolyte imbalance. Management includes first-line use of antihistamines and oral cyclizine or promethazine, with second-line options of ondansetron and metoclopramide. Admission may be needed for IV hydration. Complications can include Wernicke’s encephalopathy, Mallory-Weiss tear, central pontine myelinolysis, acute tubular necrosis, and fetal growth issues.
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This question is part of the following fields:
- Obstetrics
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