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Question 1
Correct
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A 72-year-old man comes to the clinic with a highly sensitive 0.5 cm nodule on the free border of the helix of his left ear. The nodule has been there for approximately six weeks and has a small amount of scale attached to its surface. He has trouble sleeping on that side of his head. What is the most probable diagnosis?
Your Answer: Chondrodermatitis nodularis helicis
Explanation:Chondrodermatitis Nodularis Chronica Helicis: A Benign Tender Lump in the Ear Cartilage
Chondrodermatitis nodularis chronica helicis is a common condition characterized by a benign tender lump in the cartilaginous portion of the ear, specifically in the helix or antihelix. It is often caused by pressure between the head and pillow during sleep, particularly in individuals who predominantly sleep on one side. Minor trauma, exposure to cold, and tight headgear or telephone headsets can also trigger the condition.
The lesion rarely resolves on its own and conservative measures such as using a soft pillow or sleeping on the opposite side may be attempted. Wearing a protective pressure-relieving device, using topical and intralesional steroids, or applying topical glyceryl trinitrate may also provide relief. Cryotherapy is sometimes used as well.
Excision of the damaged cartilage area is often successful, but recurrence can occur at the edge of the excised area. The distinctive feature of chondrodermatitis nodularis chronica helicis is the associated pain and tenderness, which sets it apart from painless cutaneous tumors and non-tender actinic keratoses.
It is important to note that tophi, which contain a white pasty material and are usually not painful or tender, typically develop around 10 years after the first attack of gout in untreated patients and are commonly found around the elbows, hands, and feet.
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This question is part of the following fields:
- Dermatology
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Question 2
Correct
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A 70-year-old man in a nursing home has dementia and is experiencing severe pruritus. During examination, he has excoriations on his trunk and limbs. There is some scaling on his palms, particularly in the web spaces.
What is the most probable diagnosis?Your Answer: Scabies infestation
Explanation:Skin Conditions and Diseases: Differential Diagnosis for Pruritus and Rash
When a patient presents with pruritus and a rash, it is important for doctors to consider a range of possible skin conditions and diseases. One common cause of such symptoms is scabies infestation, which can be identified by a scaly rash on the hands with burrows and scaling in the web spaces. However, the rash in scabies is nonspecific and can be mistaken for eczema, so doctors must maintain a high index of suspicion and consider scabies as a diagnosis until proven otherwise.
Other skin conditions and diseases that may cause pruritus and rash include diabetes, atopic eczema, chronic renal failure, and iron deficiency anaemia. Diabetes is associated with several skin conditions, such as necrobiosis lipoidica diabeticorum and acanthosis nigricans, but typically doesn’t present with pruritus and rash. Atopic eczema can lead to pruritus and rash, but patients with this condition usually have a long history of eczematous lesions elsewhere on their body. Chronic renal failure may cause pruritus due to uraemia, but rarely results in a skin rash. Iron deficiency anaemia may cause itching and pruritus, but doesn’t typically cause a skin rash.
In summary, when a patient presents with pruritus and rash, doctors must consider a range of possible skin conditions and diseases, including scabies infestation, diabetes, atopic eczema, chronic renal failure, and iron deficiency anaemia. A thorough differential diagnosis is necessary to accurately identify the underlying cause of the patient’s symptoms.
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This question is part of the following fields:
- Dermatology
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Question 3
Incorrect
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A 55-year-old man presents with a rash on his penis. He reports having the rash on his glans penis for approximately 6 months, with no growth and no associated itching, pain, or discharge. He is in good health otherwise.
During the examination, a well-defined, shiny, moist, orange-red plaque is observed on the glans penis. Pin-point red lesions are present within and surrounding the lesion. The patient is uncircumcised.
What is the probable diagnosis?Your Answer:
Correct Answer: Zoon's balanitis
Explanation:Zoon’s balanitis is a benign condition affecting uncircumcised men, presenting with orange-red lesions with pinpoint redder spots on the glans and adjacent areas of the foreskin. It may be secondary to other conditions such as lichen sclerosus or erythroplasia of Queyrat. Differential diagnoses include lichen sclerosus, seborrhoeic dermatitis, and psoriasis.
Understanding Zoon’s Balanitis
Zoon’s balanitis, also known as plasma cell balanitis, is a chronic condition that affects the head of the penis. It is commonly seen in middle-aged or elderly men who are not circumcised. The condition is characterized by erythematous, well-defined, and shiny patches that appear on the head of the penis.
Although Zoon’s balanitis is generally benign, a biopsy may be necessary to rule out other possible diagnoses. Circumcision is often the most effective treatment for this condition. However, carbon dioxide laser therapy and topical corticosteroids may also be used to manage the symptoms.
In summary, Zoon’s balanitis is a chronic condition that affects the head of the penis. It is typically seen in older men who are not circumcised. While circumcision is the most effective treatment, other options such as laser therapy and topical corticosteroids may also be used.
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This question is part of the following fields:
- Dermatology
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Question 4
Incorrect
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A 49-year-old man comes to the clinic complaining of wheals and urticaria. He is currently taking multiple medications.
Which medication is the most probable cause of his allergic reaction?Your Answer:
Correct Answer: Paracetamol
Explanation:Possible Causes of Urticarial Eruption
Urticaria, commonly known as hives, is a skin condition characterized by itchy, raised, and red welts. One of the most likely causes of an urticarial eruption is aspirin. However, other drugs are also frequently associated with this condition, including non-steroidal anti-inflammatory drugs (NSAIDs), penicillin, angiotensin-converting enzyme (ACE) inhibitors, thiazides, and codeine. It is important to identify the underlying cause of urticaria to prevent further episodes and manage symptoms effectively.
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This question is part of the following fields:
- Dermatology
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Question 5
Incorrect
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A young adult with psoriasis manages his flare-ups at home using potent topical steroids. He is aware of the potential side effects of continuous topical steroid use and asked about the recommended duration of break between courses of treatment according to NICE guidelines.
Your Answer:
Correct Answer: Aim for a break of 8 weeks
Explanation:Managing Psoriasis with Topical Treatments
Psoriasis patients are advised by NICE to take a break of at least 4 weeks between courses of treatment with potent or very potent corticosteroids. During this period, patients should consider using topical treatments that are not steroid-based, such as vitamin D or vitamin D analogues, or coal tar to maintain psoriasis disease control. These topical treatments can help manage psoriasis symptoms and prevent flare-ups. It is important for patients to work closely with their healthcare provider to determine the best treatment plan for their individual needs. By incorporating non-steroid topical treatments into their psoriasis management plan, patients can achieve better control of their symptoms and improve their overall quality of life.
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This question is part of the following fields:
- Dermatology
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Question 6
Incorrect
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A 15-year-old male with a history of asthma is brought in by his worried father due to the sudden appearance of a rash on his leg. The patient reports no new product usage or trauma. His father also expresses concerns about his recent lack of motivation in school.
Upon examination, there are distinct linear lesions forming geometric shapes on the left lower leg and dorsal aspect of the foot. The patient appears healthy, and there are no other notable findings.
What is the probable diagnosis?Your Answer:
Correct Answer: Dermatitis artefacta
Explanation:The sudden appearance of well-defined skin lesions in a linear pattern, accompanied by a lack of concern or emotional response, is indicative of dermatitis artefacta. This condition is often associated with self-inflicted injuries that stem from underlying psychological issues, such as deliberate self-harm or attention-seeking behavior. The lesions are typically geometric in shape and appear in easily accessible areas, such as the limbs or face. Patients with dermatitis artefacta may deny causing the lesions themselves. The patient’s declining grades may be linked to psychological difficulties that have led to this form of self-harm.
Understanding Dermatitis Artefacta
Dermatitis artefacta is a rare condition that affects individuals of any age, but is more common in females. It is characterised by self-inflicted skin lesions that patients typically deny are self-induced. The condition is strongly associated with personality disorder, dissociative disorders, and eating disorders, with a prevalence of up to 33% in patients with bulimia or anorexia.
Patients with dermatitis artefacta present with well-demarcated linear or geometric lesions that appear suddenly and do not evolve over time. The lesions may be caused by scratching with fingernails or other objects, burning skin with cigarettes, or chemical exposure. Commonly affected areas include the face and dorsum of the hands. Despite the severity of the skin lesions, patients may display a nonchalant attitude, known as la belle indifference.
Diagnosis of dermatitis artefacta is based on clinical history and exclusion of other dermatological conditions. Biopsy of skin lesions is not routine but may be helpful to exclude other conditions. Psychiatric assessment may be necessary. Differential diagnosis includes other dermatological conditions and factitious disorders such as Munchausen syndrome and malingering.
Management of dermatitis artefacta involves a multidisciplinary approach with dermatologists, psychologists, and psychiatrists. Direct confrontation is unhelpful and may discourage patients from seeking medical help. Treatment includes providing occlusive dressing, topical antibiotics, and bland emollients. Selective serotonin reuptake inhibitors and cognitive behavioural therapy may be helpful, although evidence is limited.
In summary, dermatitis artefacta is a rare condition that requires a multidisciplinary approach for management. Understanding the clinical features, risk factors, and differential diagnosis is crucial for accurate diagnosis and appropriate treatment.
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This question is part of the following fields:
- Dermatology
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Question 7
Incorrect
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Which of the following antibiotics is most commonly linked to the onset of Stevens-Johnson syndrome?
Your Answer:
Correct Answer: Co-trimoxazole
Explanation:Understanding Stevens-Johnson Syndrome
Stevens-Johnson syndrome is a severe reaction that affects the skin and mucosa, and is usually caused by a drug reaction. It was previously thought to be a severe form of erythema multiforme, but is now considered a separate entity. The condition can be caused by drugs such as penicillin, sulphonamides, lamotrigine, carbamazepine, phenytoin, allopurinol, NSAIDs, and oral contraceptive pills.
The rash associated with Stevens-Johnson syndrome is typically maculopapular, with target lesions being characteristic. It may develop into vesicles or bullae, and the Nikolsky sign is positive in erythematous areas, meaning that blisters and erosions appear when the skin is rubbed gently. Mucosal involvement and systemic symptoms such as fever and arthralgia may also occur.
Hospital admission is required for supportive treatment of Stevens-Johnson syndrome. It is important to identify and discontinue the causative drug, and to manage the symptoms of the condition. With prompt and appropriate treatment, the prognosis for Stevens-Johnson syndrome can be good.
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This question is part of the following fields:
- Dermatology
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Question 8
Incorrect
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A 55-year-old man with a history of ischaemic heart disease and psoriasis presents with a significant worsening of his plaque psoriasis on his elbows and knees over the past two weeks. His medications have been recently altered at the cardiology clinic. Which medication is most likely to have exacerbated his psoriasis?
Your Answer:
Correct Answer: Atenolol
Explanation:Plaque psoriasis is known to worsen with the use of beta-blockers.
Psoriasis can be worsened by various factors, including trauma, alcohol consumption, and certain medications such as beta blockers, lithium, antimalarials (chloroquine and hydroxychloroquine), NSAIDs, ACE inhibitors, and infliximab. Additionally, the sudden withdrawal of systemic steroids can also exacerbate psoriasis symptoms. It is important to note that streptococcal infection can trigger guttate psoriasis, a type of psoriasis characterized by small, drop-like lesions on the skin. Therefore, individuals with psoriasis should be aware of these exacerbating factors and take steps to avoid or manage them as needed.
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This question is part of the following fields:
- Dermatology
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Question 9
Incorrect
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An 80-year-old man comes to the clinic with painful swelling of his penis and a retracted foreskin. He has a long-term catheter in place. What is the most frequent cause of paraphimosis in a non-diabetic man of this age? Choose ONE answer.
Your Answer:
Correct Answer: Failure of a clinician to replace the foreskin after a procedure
Explanation:Causes of Paraphimosis: Understanding the Factors Involved
Paraphimosis is a medical condition where the foreskin becomes trapped behind the glans penis and cannot be reduced. While it can be a painful and distressing condition, it is important to understand the various factors that can contribute to its development.
One common cause of paraphimosis is the failure of a clinician to replace the foreskin after a procedure. This can occur during penile examination, cleaning, catheterisation, or cystoscopy. If the foreskin is left retracted for too long, it can become swollen and difficult to reduce.
Another potential cause is chronic balanoposthitis, which is a chronic inflammation of the glans and foreskin. While this is uncommon, it can lead to phimosis (inability to retract the foreskin) in men with diabetes.
Lichen sclerosus is another dermatological condition that can lead to phimosis. While it is uncommon, it is important to be aware of this potential cause.
Excessive sexual activity is not a common cause of paraphimosis and is not indicated by the history. However, it is important to practice safe and responsible sexual behavior to prevent any potential complications.
Finally, while sildenafil has been reported to cause priapism (a sustained painful penile erection), it is not a known cause of paraphimosis. By understanding the various factors involved in the development of paraphimosis, individuals can take steps to prevent this condition and seek appropriate medical care if necessary.
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This question is part of the following fields:
- Dermatology
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Question 10
Incorrect
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A 25-year-old man presents to the emergency department with a painful skin rash that started as circular lesions on his trunk and limbs and has now spread to his face, lips, and mouth. He also reports flu-like symptoms and headache. On examination, he has marked facial and lip swelling with crusty sores, blistering, and ulceration in the oral cavity, as well as an erythematous rash on the trunk with small vesicles and bullae. What medication is linked to this condition?
Your Answer:
Correct Answer: Lamotrigine
Explanation:Stevens-Johnson syndrome is a rare but known negative effect of lamotrigine treatment. This skin condition typically manifests within a few days of starting the medication and can cause flu-like symptoms such as fever, malaise, myalgia, and arthralgia. Painful erythema with blisters or ulcers is a hallmark of the syndrome, which can progress to areas of confluent erythema with skin loss. Mucosal involvement is also common, affecting the eyes, lips, mouth, oesophagus, upper respiratory tract (causing cough and respiratory distress), genitalia, and gastrointestinal tract (resulting in diarrhoea).
Other drugs, such as aspirin, macrolides, opiates, and cyclosporin, can also cause drug rashes. Exanthematous eruptions are a common type of drug rash, characterised by pink-to-red macules that blanch on pressure.
Urticaria and erythema multiforme are other types of drug-related rashes. Aspirin and anticonvulsants are associated with erythema multiforme, which typically presents as spot or target lesions and doesn’t involve mucosal tissues.
Lamotrigine is a medication that is primarily used as an antiepileptic drug. It is typically prescribed as a second-line treatment for a range of generalised and partial seizures. The drug works by blocking sodium channels in the body, which helps to reduce the occurrence of seizures.
Despite its effectiveness in treating seizures, lamotrigine can also cause a number of adverse effects. One of the most serious of these is Stevens-Johnson syndrome, a rare but potentially life-threatening skin condition. Other possible side effects of the drug include dizziness, headache, nausea, and blurred vision. It is important for patients taking lamotrigine to be aware of these potential risks and to report any unusual symptoms to their healthcare provider.
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This question is part of the following fields:
- Dermatology
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Question 11
Incorrect
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A woman who is 29 years old and 9 weeks pregnant visits her GP complaining of an eczematous rash on the flexures of her arms and neck, which has been present for 3 weeks and shows signs of excoriation.
What could be the probable reason for the rash?Your Answer:
Correct Answer: Atopic eruption of pregnancy
Explanation:The most commonly occurring skin disorder during pregnancy is atopic eruption of pregnancy. This condition usually starts in the first or second trimester and is characterized by a widespread eczematous eruption on the face, neck, and flexural areas. The eruption can appear as eczematous patches or intact or excoriated papules. Other less common presentations include prurigo of pregnancy or pruritic folliculitis of pregnancy.
Dermatitis herpetiformis is an autoimmune skin eruption that is associated with gluten sensitivity and is very itchy and vesicular. The lesions are typically found in the flexures of the elbow, dorsal forearms, knees, and buttocks. Immunofluorescence shows the deposition of IgA within the dermal papillae.
Intrahepatic cholestasis of pregnancy doesn’t cause a skin rash, but patients experience severe generalized pruritus mainly on the palms and soles. Excoriations may occur due to scratching.
Pemphigoid gestationis is a rare condition that usually occurs later in pregnancy (second or third trimester) and is characterized by urticarial lesions or papules surrounding the umbilicus. Vesicles may also be present.
Understanding Atopic Eruption of Pregnancy
Atopic eruption of pregnancy (AEP) is a prevalent skin condition that occurs during pregnancy. It is characterized by a red, itchy rash that resembles eczema. Although it can be uncomfortable, AEP is not harmful to the mother or the baby. Fortunately, no specific treatment is required, and the rash usually disappears after delivery.
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This question is part of the following fields:
- Dermatology
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Question 12
Incorrect
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You are evaluating a 5-year-old boy with eczema. Which of the following emollients is most likely to cause skin irritation?
Your Answer:
Correct Answer: Aqueous cream
Explanation:Aqueous Cream May Cause Skin Irritation, Warns Drug Safety Update
The use of aqueous cream as an emollient has been widely prescribed in the UK. However, a report published in the March 2013 issue of the Drug Safety Update (DSU) warns that it may cause burning and skin irritation in some patients, particularly children with eczema. The report showed that 56% of patients attending a paediatric dermatology clinic who used aqueous cream as a leave-on emollient reported skin irritation, typically within 20 minutes of application. This compared to 18% of children who used an alternative emollient. Skin irritation was not seen in patients using aqueous cream as a soap substitute. It is believed that the high sodium lauryl sulfate content in aqueous cream may be the cause of the irritation. The DSU doesn’t suggest that aqueous cream should not be prescribed, but advises that patients and parents should be warned about possible side-effects. It is recommended to routinely prescribe alternative emollients.
Spacing: 2
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This question is part of the following fields:
- Dermatology
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Question 13
Incorrect
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A 30-year-old female presents with tender, erythematous nodules over her thighs. Blood tests reveal:
Calcium 2.78 mmol/l
What is the most probable diagnosis?Your Answer:
Correct Answer: Erythema nodosum
Explanation:Understanding Erythema Nodosum
Erythema nodosum is a condition characterized by inflammation of the subcutaneous fat, resulting in tender, erythematous, nodular lesions. These lesions typically occur over the shins but may also appear on other parts of the body, such as the forearms and thighs. Fortunately, erythema nodosum usually resolves within six weeks, and the lesions heal without scarring.
There are several potential causes of erythema nodosum. Infections such as streptococci, tuberculosis, and brucellosis can trigger the condition. Systemic diseases like sarcoidosis, inflammatory bowel disease, and Behcet’s syndrome may also be responsible. In some cases, erythema nodosum may be linked to malignancy or lymphoma. Certain drugs, including penicillins, sulphonamides, and the combined oral contraceptive pill, as well as pregnancy, can also cause erythema nodosum.
Overall, understanding the potential causes of erythema nodosum can help individuals recognize the condition and seek appropriate treatment. While the condition can be uncomfortable, it typically resolves on its own within a few weeks.
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This question is part of the following fields:
- Dermatology
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Question 14
Incorrect
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A 31-year-old woman comes to the clinic complaining of a painful rash on her shins. Upon examination, there are multiple tender nodules that appear purple in color. She has no significant medical history. What is the most probable diagnosis?
Your Answer:
Correct Answer: Erythema nodosum
Explanation:Skin Conditions: Erythema Nodosum, Insect Bites, Discoid Eczema, Erysipelas, and Post-Traumatic Ecchymoses
Erythema nodosum is a painful skin condition characterized by tender, red nodules caused by inflammation of subcutaneous fat. It is more common in women aged 25-40 and can be associated with underlying conditions or occur in isolation.
Insect bites from non-venomous insects like mosquitoes, fleas, lice, and bed bugs can result in itchy papules or blisters grouped in the exposed body site. Bites often appear in clusters.
Discoid eczema is a type of eczema with unknown causes. It is characterized by round-to-oval, itchy, red, scaly plaques that may contain vesicles with serous exudate.
Erysipelas is a tender, red, indurated plaque with a well-defined border caused by group A beta-hemolytic streptococci.
Post-traumatic ecchymosis or bruises are large blood extravasations under the skin that may be caused by coagulation or vascular disorders. However, there is no history of trauma to support this diagnosis.
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This question is part of the following fields:
- Dermatology
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Question 15
Incorrect
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A 27-year-old male visits his GP after experiencing 3 episodes of prickling sensations in his left arm accompanied by involuntary jerking, lasting for a minute each time. He remains conscious during the episodes. The patient has a history of asthma and a nut allergy but is not taking any regular medications. After being referred to a neurologist, he is diagnosed with focal epilepsy and prescribed lamotrigine. What uncommon side effect should the patient be advised about, particularly in the initial 8 weeks of treatment?
Your Answer:
Correct Answer: Stevens-Johnson syndrome
Explanation:Lamotrigine therapy is associated with a rare but acknowledged adverse effect.
Lamotrigine is a medication that is primarily used as an antiepileptic drug. It is typically prescribed as a second-line treatment for a range of generalised and partial seizures. The drug works by blocking sodium channels in the body, which helps to reduce the occurrence of seizures.
Despite its effectiveness in treating seizures, lamotrigine can also cause a number of adverse effects. One of the most serious of these is Stevens-Johnson syndrome, a rare but potentially life-threatening skin condition. Other possible side effects of the drug include dizziness, headache, nausea, and blurred vision. It is important for patients taking lamotrigine to be aware of these potential risks and to report any unusual symptoms to their healthcare provider.
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This question is part of the following fields:
- Dermatology
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Question 16
Incorrect
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A 28-year-old female presents to the clinic with a 4-week history of a mild rash on her face. She reports that the rash is highly sensitive to sunlight and has been wearing hats for protection. The patient is six months postpartum and has no significant medical history.
During the examination, an erythematous rash with superficial pustules is observed on the forehead, nose, and cheeks.
What is the most effective treatment for the underlying condition?Your Answer:
Correct Answer: Topical metronidazole
Explanation:Acne rosacea is a skin condition that commonly affects fair-skinned individuals over the age of 30, with symptoms appearing on the nose, cheeks, and forehead. Flushing, erythema, and telangiectasia can progress to papules and pustules. Exacerbating factors include sunlight, pregnancy, certain drugs, and food. For mild to moderate cases, NICE recommends metronidazole as a first-line treatment, with other topical agents such as brimonidine, oxymetazoline, benzoyl peroxide, and tretinoin also being effective. Systemic antibiotics like erythromycin and tetracycline can be used for moderate to severe cases. Camouflage creams and sunscreen can help manage symptoms, but do not treat the underlying condition. Steroid creams are not recommended for acne rosacea, while topical calcineurin inhibitors may be used for other skin conditions like seborrheic dermatitis, lichen planus, and vitiligo.
Rosacea, also known as acne rosacea, is a skin condition that is chronic in nature and its cause is unknown. It typically affects the nose, cheeks, and forehead, and the first symptom is often flushing. Telangiectasia, which are small blood vessels that are visible on the skin, are common, and the condition can progress to persistent erythema with papules and pustules. Rhinophyma, a condition where the nose becomes enlarged and bulbous, can also occur. Ocular involvement, such as blepharitis, can also be present, and sunlight can exacerbate symptoms.
Management of rosacea depends on the severity of the symptoms. For mild symptoms, topical metronidazole may be used, while topical brimonidine gel may be considered for patients with predominant flushing but limited telangiectasia. More severe cases may require systemic antibiotics such as oxytetracycline. It is recommended that patients apply a high-factor sunscreen daily and use camouflage creams to conceal redness. Laser therapy may be appropriate for patients with prominent telangiectasia, and those with rhinophyma should be referred to a dermatologist for further management.
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This question is part of the following fields:
- Dermatology
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Question 17
Incorrect
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You see a 54-year old gentleman as an emergency appointment one afternoon.
He suffers with extensive psoriasis and uses a variety of topical agents. He was recently given some potent topical steroid to apply to the most severely affected areas which has not helped. Over the last few days his skin has become inflamed and he has felt generally unwell.
On examination, he has widespread generalised erythema affecting his entire body. He has a mild pyrexia and a pulse rate of 106 bpm.
What is the most appropriate course of action?Your Answer:
Correct Answer: Admit the patient to hospital as an emergency
Explanation:Erythrodermic Psoriasis: A Dermatological Emergency
Erythrodermic psoriasis is a severe form of psoriasis that requires immediate medical attention. It is characterized by widespread whole body erythema and systemic unwellness, which can lead to complications such as hypothermia and heart failure. This condition can also be caused by other dermatological conditions or medications such as lithium or anti-malarials.
Injudicious use of steroids with rapid withdrawal can also trigger erythroderma. Therefore, it is crucial to seek medical attention as soon as possible to prevent skin failure. The correct course of action is immediate hospital admission for supervised treatment. Dermatologists recommend close monitoring and management of erythrodermic psoriasis to avoid life-threatening complications.
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This question is part of the following fields:
- Dermatology
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Question 18
Incorrect
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Acne vulgaris is a common presentation to GP. One treatment option is an oral antibiotic, and tetracyclines are the first line. From the options below which patient would be suitable to receive oral tetracycline if they are 16 years old or above?
Your Answer:
Correct Answer: A 16-year-old female
Explanation:When treating acne with oral antibiotics, tetracyclines are typically the first choice. All tetracyclines are effective for treating acne, so the decision on which one to use should be based on personal preference and cost. Tetracycline and oxytetracycline are taken twice a day on an empty stomach, while doxycycline and lymecycline are taken once a day and can be taken with food. However, pregnant or breastfeeding women and children under 12 should avoid oral tetracyclines due to the risk of them being deposited in the developing child’s teeth and bones. Women of childbearing age who are taking a topical retinoid should use effective contraception. If tetracyclines are not an option, erythromycin can be used instead at a dose of 500 mg twice a day. In this case, a 16-year-old female would be a suitable candidate for tetracyclines.
Acne vulgaris is a common skin condition that usually affects teenagers and is characterized by the obstruction of hair follicles with keratin plugs, resulting in comedones, inflammation, and pustules. The severity of acne can be classified as mild, moderate, or severe, depending on the number and type of lesions present. Treatment for acne typically involves a step-up approach, starting with single topical therapy and progressing to combination therapy or oral antibiotics if necessary. Tetracyclines are commonly used but should be avoided in certain populations, and a topical retinoid or benzoyl peroxide should always be co-prescribed to reduce the risk of antibiotic resistance. Combined oral contraceptives can also be used in women, and oral isotretinoin is reserved for severe cases under specialist supervision. Dietary modification has no role in the management of acne.
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This question is part of the following fields:
- Dermatology
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Question 19
Incorrect
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A mother brings in her 5-year-old son, who has developed an itchy, red rash over the last few weeks which has been gradually worsening. It is mostly affecting the flexures and the face. The child’s mother suffers from atopic eczema and suspects that this is the problem with her son’s skin.
What is the most appropriate management option in the treatment of atopic eczema in children?Your Answer:
Correct Answer: Emollients should be continued after the eczema clears
Explanation:Best Practices for Managing Eczema: Key Recommendations
Eczema is a chronic skin condition that can cause significant discomfort and distress. While there is no cure for eczema, there are several strategies that can help manage symptoms and reduce the frequency of flare-ups. Here are some key recommendations for managing eczema:
1. Emollients should be continued after the eczema clears: Using emollients frequently can help reduce the frequency of flare-ups and the need for steroid treatment.
2. Only mildly potent corticosteroids should be used: While both mildly and moderately potent topical steroids can be used in children if needed for short courses, very potent preparations should only be used under specialist guidance.
3. Antihistamines should not be prescribed routinely: While antihistamines may provide some relief from itching, they are not recommended for routine use in the management of eczema.
4. Oral antibiotics should only be used when necessary: Antibiotics are only indicated where there is clinical suspicion of superimposed bacterial infection.
5. Topical tacrolimus should be used as a second-line treatment: Topical tacrolimus should only be used in cases that are not controlled with maximum corticosteroid therapy, or where there is high risk of side-effects from steroid use.
By following these recommendations, patients with eczema can better manage their symptoms and improve their quality of life.
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This question is part of the following fields:
- Dermatology
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Question 20
Incorrect
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A 27-year-old man comes back from a year-long trip to Central and South America. He complains of a lesion on his lower lip that has been ulcerating for the past 2 months. Upon examination, it is found that his nasal and oral mucosae are also affected. What is the probable diagnosis?
Your Answer:
Correct Answer: Leishmaniasis
Explanation:Leishmaniasis is the probable diagnosis for this patient, as the presence of a primary skin lesion accompanied by mucosal involvement is a typical indication of infection with Leishmania brasiliensis.
Leishmaniasis: A Disease Caused by Sandfly Bites
Leishmaniasis is a disease caused by the protozoa Leishmania, which are transmitted through the bites of sandflies. There are three main forms of the disease: cutaneous, mucocutaneous, and visceral. Cutaneous leishmaniasis is characterized by a crusted lesion at the site of the bite, which may be accompanied by an underlying ulcer. It is typically diagnosed through a punch biopsy from the edge of the lesion. Mucocutaneous leishmaniasis can spread to involve the mucosae of the nose, pharynx, and other areas. Visceral leishmaniasis, also known as kala-azar, is the most severe form of the disease and is characterized by fever, sweats, rigors, massive splenomegaly and hepatomegaly, poor appetite, weight loss, and grey skin. The gold standard for diagnosis is bone marrow or splenic aspirate. Treatment is necessary for cutaneous leishmaniasis acquired in South or Central America due to the risk of mucocutaneous leishmaniasis, while disease acquired in Africa or India can be managed more conservatively.
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This question is part of the following fields:
- Dermatology
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Question 21
Incorrect
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You are working in a GP practice, and your next patient is a female aged 35, who has recently registered. She is living in a hostel near to the practice. She has a previous medical history of anxiety and depression, and is coded to be an ex-intravenous drug user.
She reports having intensely itchy 'lumps' on her arms and legs for the past two weeks. Upon examination, she has multiple red bumps and raised areas on her limbs and torso, with some of these appearing in a curved line pattern. Her hands, feet, and groin are unaffected.
What is the most probable diagnosis?Your Answer:
Correct Answer: Bedbug infestation
Explanation:If a patient complains of intensely itchy bumps on their arms, torso, or legs, it may be a sign of a bed bug infestation. This is especially true if the patient has recently stayed in a hotel, hostel, or other temporary accommodation, as bed bugs can easily travel on clothing and luggage.
While scabies is a possible differential diagnosis, it is less likely if the patient doesn’t have involvement of the finger webs or linear burrows beneath the skin. Bed bug bites tend to appear as lumps or welts, rather than small spots.
If the lesions are aligned in a line or curve, this is also suggestive of a bed bug infestation, as the insects tend to move across the skin in a linear fashion.
Dealing with Bed Bugs: Symptoms, Treatment, and Prevention
Bed bugs are a type of insect that can cause a range of clinical problems, including itchy skin rashes, bites, and allergic reactions. Infestation with Cimex hemipterus is the primary cause of these symptoms. In recent years, bed bug infestations have become increasingly common in the UK, and they can be challenging to eradicate. These insects thrive in mattresses and fabrics, making them difficult to detect and eliminate.
Topical hydrocortisone can help control the itch. However, the definitive treatment for bed bugs is through a pest management company that can fumigate your home. This process can be costly, but it is the most effective way to eliminate bed bugs.
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This question is part of the following fields:
- Dermatology
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Question 22
Incorrect
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A 56-year-old man presents with a persistent cough. He reports no other health concerns and is not taking any regular medications. During the consultation, he requests a brief examination of his toenail, which has recently changed in appearance without any known cause. Specifically, the nail on his right big toe is thickened and yellowed at the outer edge. Although he experiences no discomfort or other symptoms, he is curious about the cause of this change.
What initial management approach would you recommend in this scenario?Your Answer:
Correct Answer: No treatment necessary if he is happy to leave it; give self-care advice
Explanation:If a patient has a fungal nail infection that is asymptomatic and doesn’t bother them in terms of appearance, treatment may not be necessary according to NICE CKS guidelines. However, if treatment is desired, topical antifungal treatment for 9-12 months may be appropriate for minor involvement of a single nail. Liver function tests should be checked before prescribing oral antifungal medication such as terbinafine. Self-care advice can be given to the patient, including keeping feet clean and dry, wearing breathable socks and footwear, and avoiding going barefoot in changing rooms. Referral to podiatry is not necessary unless the patient is unable to perform their own foot-care. Swabbing the skin for microscopy and culture may not be useful in cases where the skin is not involved.
Fungal Nail Infections: Causes, Symptoms, and Treatment
Fungal nail infections, also known as onychomycosis, can affect any part of the nail or the entire nail unit. However, toenails are more susceptible to infection than fingernails. The primary cause of fungal nail infections is dermatophytes, with Trichophyton rubrum being the most common. Yeasts, such as Candida, and non-dermatophyte molds can also cause fungal nail infections. Risk factors for developing a fungal nail infection include increasing age, diabetes mellitus, psoriasis, and repeated nail trauma.
The most common symptom of a fungal nail infection is thickened, rough, and opaque nails. Patients may present with unsightly nails, which can be a source of embarrassment. Differential diagnoses include psoriasis, repeated trauma, lichen planus, and yellow nail syndrome. To confirm a fungal nail infection, nail clippings or scrapings of the affected nail should be examined under a microscope and cultured. However, the false-negative rate for cultures is around 30%, so repeat samples may be necessary if clinical suspicion is high.
Asymptomatic fungal nail infections do not require treatment unless the patient is bothered by the appearance. Topical treatment with amorolfine 5% nail lacquer is recommended for limited involvement, while oral terbinafine is the first-line treatment for more extensive involvement due to a dermatophyte infection. Fingernail infections require 6 weeks to 3 months of therapy, while toenails should be treated for 3 to 6 months. Oral itraconazole is recommended for more extensive involvement due to a Candida infection, with pulsed weekly therapy being the preferred method.
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This question is part of the following fields:
- Dermatology
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Question 23
Incorrect
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A 10-year-old girl presents to the clinic with her father, reporting a rash on her ears that has been present for 3 days. They have just returned from a trip to Mexico. The girl complains of itchiness and discomfort. She has not experienced any fever or respiratory symptoms recently. On examination, small blisters are observed on the helix of both ears, while the rest of her skin appears normal. The patient has no prior medical history.
What is the most probable diagnosis?Your Answer:
Correct Answer: Juvenile spring eruption
Explanation:Juvenile spring eruption (JSE) is a skin condition that typically affects boys aged 5-14 years during the spring season. It is caused by sun exposure and appears as a blistering rash on the ears, causing discomfort and itchiness. The recent holiday to Tenerife suggests a possible risk factor for this condition. Treatment involves using emollients and antihistamines, and symptoms usually resolve within a week.
The rash associated with Chickenpox starts as red macules that become raised, blister, and crust over time. It is often accompanied by cold-like symptoms and fever and tends to be more widespread, affecting the trunk and limbs. This rash typically lasts for 4-10 days. However, since the patient has a 2-day history of a blistering rash isolated to the ears, Chickenpox is an unlikely diagnosis.
Given the patient’s short history, the characteristic rash, and the absence of any relevant medical history, eczema is an unlikely possibility.
Chondrodermatitis nodularis is a skin condition that is commonly seen in middle-aged or elderly patients. It is characterized by small skin-colored nodules that typically appear on the helix of the ear.
Understanding Juvenile Spring Eruption
Juvenile spring eruption is a skin condition that occurs as a result of sun exposure. It is a type of polymorphic light eruption (PLE) that causes itchy red bumps on the light-exposed parts of the ears, which can turn into blisters and crusts. This condition is more common in boys aged between 5-14 years, and it is less common in females due to increased amounts of hair covering the ears.
The main cause of juvenile spring eruption is sun-induced allergy rash, which is more likely to occur in the springtime. Some patients may also have PLE elsewhere on the body, and there is an increased incidence in cold weather. The diagnosis of this condition is usually made based on clinical presentation, and no clinical tests are required in most cases. However, in aggressive cases, lupus should be ruled out by ANA and ENA blood tests.
The management of juvenile spring eruption involves providing patient education on sun exposure and the use of sunscreen and hats. Topical treatments such as emollients or calamine lotion can be used to provide relief, and antihistamines can help with itch relief at night-time. In more serious cases, oral steroids such as prednisolone can be used, as well as immune-system suppressants.
In conclusion, understanding juvenile spring eruption is important for proper diagnosis and management. By taking preventative measures and seeking appropriate treatment, patients can manage their symptoms and improve their quality of life.
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This question is part of the following fields:
- Dermatology
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Question 24
Incorrect
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A 68-year-old man has a well-demarcated, raised, tender, erythematous area on his left shin. It has appeared in the last 48 hours. His temperature is 38.5 °C. The left lower leg has evidence of varicose skin changes and excoriation.
What is the most likely causative organism?Your Answer:
Correct Answer: Streptococcus
Explanation:Understanding the Causes of Cellulitis: Streptococcus, Staphylococcus, Herpes Simplex Virus, Pseudomonas, and Varicella Zoster Virus
Cellulitis is a common skin infection that is characterized by a red, tender area of skin associated with a fever. The most common pathogen causing cellulitis is streptococcus, which can enter the body through excoriated skin. Staphylococcus can also cause cellulitis, but it is less common than streptococcus. Herpes simplex virus typically causes cold sores or genital warts, and can be inoculated into abrasions, but this would produce a vesicular rash. Pseudomonas is not a common pathogen in cellulitis, but can occur following puncture wounds or in immunocompromised people. Varicella zoster virus causes Chickenpox and shingles, but neither of these descriptions are seen in cellulitis. Understanding the different causes of cellulitis can help with proper diagnosis and treatment.
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This question is part of the following fields:
- Dermatology
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Question 25
Incorrect
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A 28-year-old man who is living in a hostel complains of a 2-week history of intense itching. Papules and burrows can be seen between his fingers.
What is the most appropriate treatment?Your Answer:
Correct Answer: Permethrin 5% preparation
Explanation:Treatment Options for Scabies and Head Lice
Scabies is a skin condition characterized by intense itching and visible burrows in the finger webs. The first-line treatment for scabies is permethrin 5%, which should be applied to all household members and followed by washing of bedding and towels. If permethrin cannot be used due to allergy, malathion 0.5% aqueous solution can be used as a second-line treatment. Benzyl benzoate 25% emulsion is an older treatment for scabies and has been replaced by more effective methods.
On the other hand, head lice can be treated with permethrin 1%, which is not strong enough for scabies treatment. It is important to note that ivermectin 200 µg/kg orally is only used for crusted scabies, which causes a generalized rash with lots of scale. Topical permethrin remains the ideal treatment for scabies.
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This question is part of the following fields:
- Dermatology
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Question 26
Incorrect
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A 65-year-old man visits his GP urgently due to a recent increase in his INR levels. He has been on Warfarin for a decade and has consistently maintained an INR reading between 2 and 3. However, his most recent blood test showed an INR of 6.2. He reports receiving a topical medication for a facial rash at a walk-in centre two weeks ago.
What is the most probable treatment that led to the elevation in his INR?Your Answer:
Correct Answer: Mupirocin
Explanation:Miconazole Oral Gel and Warfarin Interaction
Miconazole oral gel, commonly known as Daktarin, is often used to treat candidal infections of the mouth and face. However, it can interact with the anticoagulant drug warfarin, which is metabolized by the CYP2C9 enzyme. Miconazole inhibits this enzyme, leading to increased levels of warfarin in the bloodstream and potentially causing bleeding. Other antimicrobial agents like Aciclovir, Clotrimazole, Fucidin, and Mupirocin can be used to treat infected rashes on the face, but they do not have significant interactions with warfarin. As a core competence of clinical management, safe prescribing and medicines management approaches should include awareness of common drug interactions, especially those that can affect patient safety when taking warfarin.
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This question is part of the following fields:
- Dermatology
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Question 27
Incorrect
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A 55-year-old man presents to the emergency department with burns on the extensor aspects of his lower legs. He accidentally spilled hot water on himself while wearing shorts. Upon examination, he has pale, pink skin with small blisters forming. The burns are classified as superficial dermal burns. Using a chart, you calculate the TBSA of the burns. What is the minimum TBSA that would require immediate referral to the plastic surgeons?
Your Answer:
Correct Answer: 3%
Explanation:First Aid and Management of Burns
Burns can be caused by heat, electricity, or chemicals. Immediate first aid involves removing the person from the source of the burn and irrigating the affected area with cool water. The extent of the burn can be assessed using Wallace’s Rule of Nines or the Lund and Browder chart. The depth of the burn can be determined by its appearance, with full-thickness burns being the most severe. Referral to secondary care is necessary for deep dermal and full-thickness burns, as well as burns involving certain areas of the body or suspicion of non-accidental injury.
Severe burns can lead to tissue loss, fluid loss, and a catabolic response. Intravenous fluids and analgesia are necessary for resuscitation and pain relief. Smoke inhalation can result in airway edema, and early intubation may be necessary. Circumferential burns may require escharotomy to relieve compartment syndrome and improve ventilation. Conservative management is appropriate for superficial burns, while more complex burns may require excision and skin grafting. There is no evidence to support the use of antimicrobial prophylaxis or topical antibiotics in burn patients.
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This question is part of the following fields:
- Dermatology
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Question 28
Incorrect
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A 19-year-old girl presents to you with concerns about her acne on her face, chest, and upper back. She is feeling self-conscious about it, especially after her boyfriend made some comments about her skin. She has been using a combination of topical benzoyl peroxide and antibiotics for the past few months.
Upon examination, you note the presence of comedones, papules, and pustules, but no nodules or cysts. There is no scarring.
What is the recommended first-line treatment for her acne at this stage?Your Answer:
Correct Answer: Lymecycline
Explanation:Since the topical preparation did not work for the patient, the next step would be to try an oral antibiotic. The recommended first-line options are lymecycline, oxytetracycline, tetracycline, or doxycycline. Lymecycline is preferred as it only needs to be taken once a day, which can improve the patient’s adherence to the treatment.
Acne vulgaris is a common skin condition that usually affects teenagers and is characterized by the obstruction of hair follicles with keratin plugs, resulting in comedones, inflammation, and pustules. The severity of acne can be classified as mild, moderate, or severe, depending on the number and type of lesions present. Treatment for acne typically involves a step-up approach, starting with single topical therapy and progressing to combination therapy or oral antibiotics if necessary. Tetracyclines are commonly used but should be avoided in certain populations, and a topical retinoid or benzoyl peroxide should always be co-prescribed to reduce the risk of antibiotic resistance. Combined oral contraceptives can also be used in women, and oral isotretinoin is reserved for severe cases under specialist supervision. Dietary modification has no role in the management of acne.
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This question is part of the following fields:
- Dermatology
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Question 29
Incorrect
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A 58-year-old male is referred to dermatology by his physician for a lesion on his forearm. The lesion began as a small red bump and has since progressed into a deep, red, necrotic ulcer with a violaceous border. What is the probable diagnosis?
Your Answer:
Correct Answer: Pyoderma gangrenosum
Explanation:Understanding Shin Lesions: Differential Diagnosis and Characteristics
Shin lesions can be caused by various conditions, and it is important to differentiate between them to provide appropriate treatment. The four most common conditions that can cause shin lesions are erythema nodosum, pretibial myxoedema, pyoderma gangrenosum, and necrobiosis lipoidica diabeticorum.
Erythema nodosum is characterized by symmetrical, tender, erythematous nodules that heal without scarring. It is commonly caused by streptococcal infections, sarcoidosis, inflammatory bowel disease, and certain medications such as penicillins, sulphonamides, and oral contraceptive pills.
Pretibial myxoedema, on the other hand, is seen in Graves’ disease and is characterized by symmetrical, erythematous lesions that give the skin a shiny, orange peel appearance.
Pyoderma gangrenosum starts as a small red papule and later develops into deep, red, necrotic ulcers with a violaceous border. It is idiopathic in 50% of cases but may also be associated with inflammatory bowel disease, connective tissue disorders, and myeloproliferative disorders.
Finally, necrobiosis lipoidica diabeticorum is characterized by shiny, painless areas of yellow/red skin typically found on the shin of diabetics. It is often associated with telangiectasia.
Understanding the differential diagnosis and characteristics of shin lesions can help healthcare professionals provide appropriate treatment and improve patient outcomes.
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This question is part of the following fields:
- Dermatology
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Question 30
Incorrect
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A 60-year-old man presents to your clinic with complaints of weight loss, fatigue, and skin changes under his arms. During the examination, you notice thickened dark pigmented areas of skin under both arms. What underlying condition is typically linked to this clinical sign?
Your Answer:
Correct Answer: Carcinoma stomach
Explanation:Understanding Acanthosis Nigricans
Acanthosis nigricans (AN) is a skin condition that is characterized by darkening and thickening of the skin in certain areas such as the armpits, groin, and back of the neck. However, it is not a skin disease in itself but rather a sign of an underlying condition or disease. In some cases, AN can be a paraneoplastic syndrome, commonly known as acanthosis nigricans maligna, which is associated with an internal malignancy, particularly adenocarcinoma of the gastrointestinal tract or uterus. AN is more commonly seen in individuals over the age of 40 and is often linked to obesity and insulin resistance.
It is important to note that AN of the oral mucosa or tongue is highly suggestive of a neoplasm, particularly of the gastrointestinal tract.
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This question is part of the following fields:
- Dermatology
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