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  • Question 1 - A 25-year-old female patient complains of hypopigmented skin lesions on her chest and...

    Incorrect

    • A 25-year-old female patient complains of hypopigmented skin lesions on her chest and back. She has just come back from a trip to Spain and has a tanned complexion. During examination, the lesions appear to be slightly scaly. What is the probable diagnosis?

      Your Answer: Tinea corporis

      Correct Answer: Pityriasis versicolor

      Explanation:

      Understanding Pityriasis Versicolor

      Pityriasis versicolor, also known as tinea versicolor, is a fungal infection that affects the skin’s surface. It is caused by Malassezia furfur, which was previously known as Pityrosporum ovale. This condition is characterized by patches that may be hypopigmented, pink, or brown, and it is most commonly found on the trunk. The patches may become more noticeable following a suntan, and scaling is a common symptom. Mild pruritus may also occur.

      Pityriasis versicolor can affect healthy individuals, but it is more likely to occur in those who are immunosuppressed, malnourished, or have Cushing’s syndrome. Treatment typically involves the use of topical antifungal medications, with ketoconazole shampoo being the recommended option due to its cost-effectiveness for larger areas. If topical treatment fails, alternative diagnoses should be considered, and oral itraconazole may be prescribed. Scrapings may also be sent for confirmation of the diagnosis. Understanding the features, predisposing factors, and management of pityriasis versicolor can help individuals recognize and effectively treat this common fungal infection.

    • This question is part of the following fields:

      • Dermatology
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  • Question 2 - A 75-year-old woman visits her general practitioner with a complaint of itchy white...

    Correct

    • A 75-year-old woman visits her general practitioner with a complaint of itchy white plaques on her vulva and inner thigh. She denies experiencing any vaginal discharge or bleeding. What is the probable diagnosis?

      Your Answer: Lichen sclerosus

      Explanation:

      Lichen sclerosus is a condition characterized by itchy white spots that are commonly observed on the vulva of older women. While candida can also cause itching and white patches, it would not result in lesions appearing on the inner thigh as well.

      Understanding Lichen Sclerosus

      Lichen sclerosus, previously known as lichen sclerosus et atrophicus, is an inflammatory condition that commonly affects the genitalia, particularly in elderly females. This condition leads to the atrophy of the epidermis, resulting in the formation of white plaques. The most prominent feature of lichen sclerosus is the presence of white patches that may scar. Patients may also experience itching and pain during intercourse or urination.

      Diagnosis of lichen sclerosus is usually made based on clinical examination, but a biopsy may be performed if atypical features are present. Management of this condition involves the use of topical steroids and emollients. Patients with lichen sclerosus are at an increased risk of developing vulval cancer, and routine follow-up is necessary to monitor for any changes.

      The Royal College of Obstetricians and Gynaecologists advise against performing a skin biopsy if a diagnosis can be made on clinical examination. However, a biopsy may be necessary if the patient fails to respond to treatment or if there is a suspicion of neoplastic change. The British Association of Dermatologists also recommends a biopsy if there are atypical features or diagnostic uncertainty. Patients under routine follow-up will need a biopsy if there is a suspicion of neoplastic change, if the disease fails to respond to treatment, if there is extragenital lichen sclerosus, or if second-line therapy is to be used.

      Understanding lichen sclerosus is important for early diagnosis and management of this condition. Patients with this condition should seek medical attention if they experience any symptoms or changes in their condition.

    • This question is part of the following fields:

      • Dermatology
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  • Question 3 - A 67-year-old woman presents to General Practitioner with a 2-day history of fever...

    Correct

    • A 67-year-old woman presents to General Practitioner with a 2-day history of fever and pain in her right shin.
      On examination, she was found to have a tender erythematous skin swelling in the anterior aspect of her right shin. This measured around 10 cm × 4 cm. Her temperature was 38.2°C and the rest of her parameters included a heart rate of 120 bpm, respiratory rate of 21 bpm and oxygen saturation of 99%.
      What is the most appropriate next investigation?
      Select the SINGLE best option from the list below.
      Select ONE option only.

      Your Answer: Full blood count, urea and electrolytes and C-reactive protein (CRP)/erythrocyte sedimentation rate (ESR)

      Explanation:

      Diagnostic Tests for Cellulitis: Which Ones are Necessary?

      Cellulitis is a clinical diagnosis, but certain tests may be necessary in patients with a systemic response. A full blood count, urea and electrolytes, and CRP/ESR are recommended to assess the severity of the infection. A wound swab and blood cultures may also be considered. An ABPI measurement is indicated in patients with suspected lower-limb arterial disease. A chest X-ray is not necessary unless co-existing lung pathology is suspected. In stable patients with no systemic upset, no further investigations are needed. A punch biopsy is not necessary for diagnosis but may be considered in other skin conditions.

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      • Dermatology
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  • Question 4 - You are examining a 7-month-old infant who has a capillary haemangioma located on...

    Incorrect

    • You are examining a 7-month-old infant who has a capillary haemangioma located on the right cheek that is beginning to interfere with their vision. Following a conversation with the parents, you have decided to initiate treatment for this area due to the potential impact on eyesight.

      What is the primary treatment option for capillary haemangioma?

      Your Answer: Surgical removal

      Correct Answer: Propranolol

      Explanation:

      When it comes to capillary haemangiomas that require intervention, the preferred treatment is propranolol. Other options include laser therapy or systemic steroids, but topical steroids are unlikely to be effective. Surgery is generally not recommended for most cases.

      Understanding Strawberry Naevus

      Strawberry naevus, also known as capillary haemangioma, is a type of skin condition that usually develops in infants within the first month of life. It is characterized by raised, erythematous, and multilobed tumours that commonly appear on the face, scalp, and back. While it is not present at birth, it can grow rapidly and reach its peak size at around 6-9 months before regressing over the next few years. In fact, around 95% of cases resolve before the child reaches 10 years of age. However, there are potential complications that may arise, such as obstructing visual fields or airway, bleeding, ulceration, and thrombocytopaenia.

      Capillary haemangiomas are more common in white infants, particularly in female and premature infants, as well as those whose mothers have undergone chorionic villous sampling. In cases where treatment is necessary, propranolol is now the preferred choice over systemic steroids. Topical beta-blockers like timolol may also be used. It is important to note that there is a deeper type of capillary haemangioma called cavernous haemangioma. Understanding the nature of strawberry naevus is crucial in managing its potential complications and providing appropriate treatment.

    • This question is part of the following fields:

      • Dermatology
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  • Question 5 - A 25-year-old woman in her first trimester of pregnancy presents for a check-up....

    Incorrect

    • A 25-year-old woman in her first trimester of pregnancy presents for a check-up. She is experiencing a resurgence of her chronic acne and is interested in finding a solution. What should she steer clear of?

      Your Answer: Topical azelaic acid

      Correct Answer: Topical isotretinoin

      Explanation:

      Acne vulgaris is a common skin condition that typically affects adolescents, with the face, neck, and upper trunk being the most commonly affected areas. It is characterized by the obstruction of hair follicles with keratin plugs, leading to the formation of comedones, inflammation, and pustules. The severity of acne can be classified as mild, moderate, or severe, depending on the presence and extent of inflammatory lesions, papules, and pustules.

      The management of acne vulgaris typically involves a step-up approach, starting with single topical therapy such as topical retinoids or benzoyl peroxide. If this is not effective, topical combination therapy may be used, which includes a topical antibiotic, benzoyl peroxide, and topical retinoid. Oral antibiotics such as tetracyclines may also be prescribed, but they should be avoided in pregnant or breastfeeding women and children under 12 years of age. Erythromycin may be used in pregnancy, while minocycline is now considered less appropriate due to the possibility of irreversible pigmentation. Oral antibiotics should be used for a maximum of three months and always co-prescribed with a topical retinoid or benzoyl peroxide to reduce the risk of antibiotic resistance.

      Combined oral contraceptives (COCP) are an alternative to oral antibiotics in women, and Dianette (co-cyrindiol) may be used as it has anti-androgen properties. However, it has an increased risk of venous thromboembolism compared to other COCPs, so it should generally be used second-line and for only three months. Oral isotretinoin is a potent medication that should only be used under specialist supervision, and it is contraindicated in pregnancy. Finally, there is no evidence to support dietary modification in the management of acne vulgaris.

    • This question is part of the following fields:

      • Dermatology
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  • Question 6 - A 25-year-old man visits his GP complaining of a rash that has spread...

    Incorrect

    • A 25-year-old man visits his GP complaining of a rash that has spread across his trunk over the last 4 days. He is worried about the appearance of the rash. The patient has no significant medical history except for completing a course of phenoxymethylpenicillin for tonsillitis last week and takes no other regular medications. Upon examination, the doctor observes multiple scaly papules on the patient's trunk and upper limbs. The lesions are small and have a teardrop shape. What is the most probable diagnosis?

      Your Answer: Pityriasis rosea

      Correct Answer: Guttate psoriasis

      Explanation:

      The tear-drop scaly papules that have suddenly appeared on the patient’s trunk and limbs suggest guttate psoriasis. This type of psoriasis is commonly seen in children and young adults who have recently had a Streptococcus infection, such as the tonsillitis infection that this patient had. The rash is characterized by multiple small scaly and red patches that have a teardrop shape.

      Disseminated varicella zoster, pityriasis rosea, and pityriasis versicolor are not likely diagnoses for this patient. Disseminated varicella zoster causes a different type of rash that includes macular, papular, and vesicular lesions that crust over time. Pityriasis rosea presents with a large round herald patch on the chest, abdomen, or back, and is thought to be triggered by viral or bacterial infections. Pityriasis versicolor is a fungal infection that causes patches that are paler than the surrounding skin, and is commonly found on the upper limbs and neck. However, exposure to heat and moisture can increase the risk of developing this rash.

      Guttate psoriasis is a type of psoriasis that is more commonly seen in children and adolescents. It is often triggered by a streptococcal infection that occurred 2-4 weeks prior to the appearance of the lesions. The name guttate comes from the Latin word for drop, as the lesions appear as small, tear-shaped papules on the trunk and limbs. These papules are pink and scaly, and the onset of the condition is usually acute, occurring over a few days.

      In most cases, guttate psoriasis will resolve on its own within 2-3 months. There is no clear evidence to support the use of antibiotics to treat the underlying streptococcal infection. Treatment options for guttate psoriasis include topical agents commonly used for psoriasis and UVB phototherapy. In cases where the condition recurs, a tonsillectomy may be necessary.

      It is important to differentiate guttate psoriasis from pityriasis rosea, another skin condition that can present with similar symptoms. Guttate psoriasis is often preceded by a streptococcal sore throat, while pityriasis rosea may be preceded by a respiratory tract infection. The appearance of guttate psoriasis is characterized by tear-shaped papules on the trunk and limbs, while pityriasis rosea presents with a herald patch followed by multiple oval lesions with a fine scale. While guttate psoriasis resolves within a few months, pityriasis rosea typically resolves after around 6 weeks.

    • This question is part of the following fields:

      • Dermatology
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  • Question 7 - An itchy rash over the extensor surfaces in a patient with gluten intolerance:...

    Correct

    • An itchy rash over the extensor surfaces in a patient with gluten intolerance:

      Your Answer: Dermatitis herpetiformis

      Explanation:

      Dermatitis herpetiformis is the correct answer, which is a skin rash that is closely linked to coeliac disease. This is a persistent skin condition that causes blisters, but it is not caused by or related to the herpes virus. It is important to note that dapsone is an effective treatment for Dermatitis herpetiformis, which is a common question in exams. Additionally, a gluten-free diet can also help alleviate symptoms.

      Understanding Dermatitis Herpetiformis

      Dermatitis herpetiformis is a skin condition that is linked to coeliac disease and is caused by the deposition of IgA in the dermis. It is an autoimmune blistering disorder that is characterized by itchy, vesicular skin lesions that appear on the extensor surfaces of the body, such as the elbows, knees, and buttocks.

      To diagnose dermatitis herpetiformis, a skin biopsy is required, which will show the deposition of IgA in a granular pattern in the upper dermis. This condition can be managed by following a gluten-free diet and taking dapsone medication.

      It is important to understand the symptoms and management of dermatitis herpetiformis to ensure that proper treatment is given. By following a gluten-free diet and taking medication, individuals with this condition can manage their symptoms and improve their quality of life.

    • This question is part of the following fields:

      • Dermatology
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  • Question 8 - A 26-year-old presents with a rash that developed after a camping trip. He...

    Correct

    • A 26-year-old presents with a rash that developed after a camping trip. He mentions being bitten by a tick during the trip. He explains that the rash is red, not itchy, and began at the site of the bite before spreading outward. The center of the rash has now cleared, resulting in a bulls-eye appearance. What is the name of this rash?

      Your Answer: Erythema migrans

      Explanation:

      Lyme Disease: Symptoms and Progression

      Lyme disease is a bacterial infection that is transmitted through the bite of an infected tick. The disease progresses in two stages, with early and later features. The early features of Lyme disease include erythema migrans, which is a small papule that often appears at the site of the tick bite. This papule develops into a larger annular lesion with central clearing, resembling a bulls-eye. This occurs in 70% of patients and is accompanied by systemic symptoms such as malaise, fever, and arthralgia.

      In the later stages of Lyme disease, patients may experience cardiovascular symptoms such as heart block and myocarditis. Neurological symptoms may also occur, including cranial nerve palsies and meningitis. Additionally, patients may develop polyarthritis, which is inflammation in multiple joints. It is important to seek medical attention if any of these symptoms occur after a tick bite, as early treatment can prevent the progression of the disease.

    • This question is part of the following fields:

      • Dermatology
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  • Question 9 - A 5-year-old girl is presented to your GP clinic by her father with...

    Incorrect

    • A 5-year-old girl is presented to your GP clinic by her father with a complaint of erythematous sores on her face for the past 2 days. The lesions are limited to her face and have started to weep and progress to honey crusted lesions over the last 24 hours. The child is otherwise healthy. Previously, topical hydrogen peroxide was ineffective for a similar episode. What is the most appropriate treatment option?

      Your Answer: Topical mupirocin

      Correct Answer: Topical fusidic acid

      Explanation:

      If hydrogen peroxide is not appropriate, topical fusidic acid can be used for impetigo.

      Understanding Impetigo: Causes, Symptoms, and Management

      Impetigo is a common bacterial skin infection that affects both children and adults. It is caused by either Staphylococcus aureus or Streptococcus pyogenes and can develop anywhere on the body, but lesions tend to occur on the face, flexures, and limbs not covered by clothing. The infection can be a primary infection or a complication of an existing skin condition such as eczema, scabies, or insect bites. Impetigo is highly contagious and can spread through direct contact with discharges from the scabs of an infected person or indirectly through toys, clothing, equipment, and the environment.

      The symptoms of impetigo include ‘golden’, crusted skin lesions typically found around the mouth. The infection can be managed with limited, localized disease by using hydrogen peroxide 1% cream or topical antibiotic creams such as fusidic acid or mupirocin. However, if the disease is extensive, oral flucloxacillin or oral erythromycin may be prescribed. It is important to note that MRSA is not susceptible to either fusidic acid or retapamulin, so topical mupirocin should be used in this situation.

      Children with impetigo should be excluded from school until the lesions are crusted and healed or 48 hours after commencing antibiotic treatment. It is also important to practice good hygiene, such as washing hands regularly and avoiding close contact with infected individuals, to prevent the spread of impetigo. By understanding the causes, symptoms, and management of impetigo, individuals can take steps to prevent and treat this common bacterial skin infection.

    • This question is part of the following fields:

      • Dermatology
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  • Question 10 - A 50-year-old woman presents to dermatology after being referred by her physician for...

    Incorrect

    • A 50-year-old woman presents to dermatology after being referred by her physician for lesions on both shins. Upon examination, symmetrical erythematous lesions with an orange peel texture are observed. What is the probable diagnosis?

      Your Answer: Erythema nodosum

      Correct Answer: Pretibial myxoedema

      Explanation:

      Pretibial myxoedema is a condition characterized by orange peel-like lesions on the skin of the shins, often associated with Grave’s disease.

      Understanding Shin Lesions: Differential Diagnosis and Characteristic Features

      Shin lesions can be caused by a variety of conditions, and it is important to differentiate between them in order to provide appropriate treatment. The four most common conditions that can cause shin lesions are erythema nodosum, pretibial myxoedema, pyoderma gangrenosum, and necrobiosis lipoidica diabeticorum.

      Erythema nodosum is characterized by symmetrical, tender, erythematous nodules that heal without scarring. It is often caused by streptococcal infections, sarcoidosis, inflammatory bowel disease, or certain medications such as penicillins, sulphonamides, or oral contraceptive pills.

      Pretibial myxoedema, on the other hand, is seen in Graves’ disease and is characterized by symmetrical, erythematous lesions that give the skin a shiny, orange peel appearance.

      Pyoderma gangrenosum initially presents as a small red papule, which later develops into deep, red, necrotic ulcers with a violaceous border. It is idiopathic in 50% of cases, but may also be seen in inflammatory bowel disease, connective tissue disorders, and myeloproliferative disorders.

      Finally, necrobiosis lipoidica diabeticorum is characterized by shiny, painless areas of yellow/red skin typically found on the shin of diabetics. It is often associated with telangiectasia.

      In summary, understanding the differential diagnosis and characteristic features of shin lesions can help healthcare professionals provide appropriate treatment and improve patient outcomes.

    • This question is part of the following fields:

      • Dermatology
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  • Question 11 - A 16-year-old female comes to the clinic complaining of a painful and itchy...

    Incorrect

    • A 16-year-old female comes to the clinic complaining of a painful and itchy rash that has rapidly worsened in the last 12 hours. She has a history of atopic dermatitis and hayfever, which have been treated with emollients. Upon examination, she has a monomorphic rash with punched out erosions on her cheeks and bilateral dorsal wrists. The doctors admit her for observation and IV antivirals. What is the most likely pathogen responsible for her condition?

      Your Answer: Coxsackie virus A

      Correct Answer: Herpes simplex 1

      Explanation:

      Eczema herpeticum is a skin infection primarily caused by herpes simplex virus (HSV) and, in rare cases, coxsackievirus. Herpes zoster leads to chickenpox, roseola is caused by HHV 6, and molluscum contagiosum is caused by poxvirus.

      Understanding Eczema Herpeticum

      Eczema herpeticum is a serious skin infection caused by herpes simplex virus 1 or 2. It is commonly observed in children with atopic eczema and is characterized by a rapidly progressing painful rash. The infection can be life-threatening, which is why it is important to seek medical attention immediately.

      During examination, doctors typically observe monomorphic punched-out erosions, which are circular, depressed, and ulcerated lesions that are usually 1-3 mm in diameter. Due to the severity of the infection, children with eczema herpeticum should be admitted to the hospital for intravenous aciclovir treatment. It is important to understand the symptoms and seek medical attention promptly to prevent any complications.

    • This question is part of the following fields:

      • Dermatology
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  • Question 12 - A 45-year-old female patient complains of painful erythematous lesions on her shins. Which...

    Incorrect

    • A 45-year-old female patient complains of painful erythematous lesions on her shins. Which of the following is not commonly associated with this presentation?

      Your Answer: Tuberculosis

      Correct Answer: Syphilis

      Explanation:

      Erythema nodosum caused by syphilis is uncommon.

      Understanding Erythema Nodosum

      Erythema nodosum is a condition characterized by inflammation of the subcutaneous fat, resulting in tender, erythematous, nodular lesions. These lesions typically occur over the shins but may also appear on other parts of the body such as the forearms and thighs. The condition usually resolves within six weeks, and the lesions heal without scarring.

      There are several possible causes of erythema nodosum, including infections such as streptococci, tuberculosis, and brucellosis. Systemic diseases like sarcoidosis, inflammatory bowel disease, and Behcet’s can also lead to the condition. In some cases, erythema nodosum may be associated with malignancy or lymphoma. Certain drugs like penicillins, sulphonamides, and the combined oral contraceptive pill, as well as pregnancy, can also trigger the condition.

      Overall, understanding the causes and symptoms of erythema nodosum is important for prompt diagnosis and treatment.

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      • Dermatology
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  • Question 13 - A 4-year-old boy is brought to the doctor's office because of a rash...

    Correct

    • A 4-year-old boy is brought to the doctor's office because of a rash on his upper arm. During the examination, the doctor observes several raised lesions that are approximately 2 mm in diameter. Upon closer inspection, a central dimple is visible in most of the lesions. What is the probable diagnosis?

      Your Answer: Molluscum contagiosum

      Explanation:

      Understanding Molluscum Contagiosum

      Molluscum contagiosum is a viral skin infection that is commonly seen in children, particularly those with atopic eczema. It is caused by the molluscum contagiosum virus and can be transmitted through direct contact or contaminated surfaces. The infection presents as pinkish or pearly white papules with a central umbilication, which can appear anywhere on the body except for the palms of the hands and soles of the feet. In children, lesions are commonly seen on the trunk and in flexures, while in adults, sexual contact may lead to lesions developing on the genitalia, pubis, thighs, and lower abdomen.

      While molluscum contagiosum is a self-limiting condition that usually resolves within 18 months, it is important to avoid sharing towels, clothing, and baths with uninfected individuals to prevent transmission. Scratching the lesions should also be avoided, and treatment may be considered if the itch is problematic. However, treatment is not usually recommended, and if necessary, simple trauma or cryotherapy may be used. In some cases, referral may be necessary, such as for individuals who are HIV-positive with extensive lesions or those with eyelid-margin or ocular lesions and associated red eye.

      Overall, understanding molluscum contagiosum and taking appropriate precautions can help prevent transmission and alleviate symptoms.

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      • Dermatology
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  • Question 14 - A 28-year-old newly qualified nurse presents with a bilateral erythematous rash on both...

    Correct

    • A 28-year-old newly qualified nurse presents with a bilateral erythematous rash on both hands. She has recently moved from the Philippines and has no significant medical history. The suspected diagnosis is contact dermatitis. What is the most appropriate test to determine the underlying cause?

      Your Answer: Skin patch test

      Explanation:

      The skin patch test can be beneficial in this scenario as it has the potential to detect irritants in addition to allergens.

      Types of Allergy Tests

      Allergy tests are used to determine if a person has an allergic reaction to a particular substance. There are several types of allergy tests available, each with its own advantages and limitations. The most commonly used test is the skin prick test, which is easy to perform and inexpensive. Drops of diluted allergen are placed on the skin, and a needle is used to pierce the skin. A wheal will typically develop if a patient has an allergy. This test is useful for food allergies and pollen.

      Another type of allergy test is the radioallergosorbent test (RAST), which determines the amount of IgE that reacts specifically with suspected or known allergens. Results are given in grades from 0 (negative) to 6 (strongly positive). This test is useful for food allergies, inhaled allergens (e.g. pollen), and wasp/bee venom.

      Skin patch testing is useful for contact dermatitis. Around 30-40 allergens are placed on the back, and irritants may also be tested for. The patches are removed 48 hours later, and the results are read by a dermatologist after a further 48 hours. Blood tests may be used when skin prick tests are not suitable, for example if there is extensive eczema or if the patient is taking antihistamines. Overall, allergy tests are an important tool in diagnosing and managing allergies.

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      • Dermatology
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  • Question 15 - A 65-year-old man with a history of Parkinson's disease comes to the clinic...

    Incorrect

    • A 65-year-old man with a history of Parkinson's disease comes to the clinic complaining of an itchy, red rash on his neck, behind his ears, and around the nasolabial folds. He experienced a similar outbreak last year but did not seek medical attention. What is the probable diagnosis?

      Your Answer: Levodopa associated dermatitis

      Correct Answer: Seborrhoeic dermatitis

      Explanation:

      Patients with Parkinson’s disease are more likely to experience seborrhoeic dermatitis.

      Understanding Seborrhoeic Dermatitis in Adults

      Seborrhoeic dermatitis is a chronic skin condition that affects around 2% of the general population. It is caused by an inflammatory reaction related to the overgrowth of a fungus called Malassezia furfur, which is a normal inhabitant of the skin. The condition is characterized by eczematous lesions that appear on the sebum-rich areas of the body, such as the scalp, periorbital, auricular, and nasolabial folds. It can also lead to the development of otitis externa and blepharitis.

      Seborrhoeic dermatitis is often associated with other medical conditions, such as HIV and Parkinson’s disease. The management of the condition depends on the affected area. For scalp disease, over-the-counter preparations containing zinc pyrithione and tar are usually the first-line treatment. If these are not effective, ketoconazole is the preferred second-line agent. Selenium sulphide and topical corticosteroids may also be useful.

      For the face and body, topical antifungals such as ketoconazole and topical steroids are often used. However, it is important to use steroids for short periods only to avoid side effects. Seborrhoeic dermatitis can be difficult to treat, and recurrences are common. Therefore, it is important to work closely with a healthcare provider to manage the condition effectively.

    • This question is part of the following fields:

      • Dermatology
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  • Question 16 - A 28-year-old man who is HIV positive has been diagnosed with seborrhoeic dermatitis....

    Incorrect

    • A 28-year-old man who is HIV positive has been diagnosed with seborrhoeic dermatitis. What are the two most commonly associated complications with this condition?

      Your Answer: Blepharitis and alopecia

      Correct Answer: Blepharitis and otitis externa

      Explanation:

      Seborrhoeic dermatitis often leads to otitis externa and blepharitis as complications. Although rare, alopecia may occur if a severe secondary infection develops.

      Understanding Seborrhoeic Dermatitis in Adults

      Seborrhoeic dermatitis is a chronic skin condition that affects around 2% of the general population. It is caused by an inflammatory reaction related to the overgrowth of a fungus called Malassezia furfur, which is a normal inhabitant of the skin. The condition is characterized by eczematous lesions that appear on the sebum-rich areas of the body, such as the scalp, periorbital, auricular, and nasolabial folds. It can also lead to the development of otitis externa and blepharitis.

      Seborrhoeic dermatitis is often associated with other medical conditions, such as HIV and Parkinson’s disease. The management of the condition depends on the affected area. For scalp disease, over-the-counter preparations containing zinc pyrithione and tar are usually the first-line treatment. If these are not effective, ketoconazole is the preferred second-line agent. Selenium sulphide and topical corticosteroids may also be useful.

      For the face and body, topical antifungals such as ketoconazole and topical steroids are often used. However, it is important to use steroids for short periods only to avoid side effects. Seborrhoeic dermatitis can be difficult to treat, and recurrences are common. Therefore, it is important to work closely with a healthcare provider to manage the condition effectively.

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      • Dermatology
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  • Question 17 - A 25-year-old woman presents to her General Practitioner concerned about a red, itchy...

    Correct

    • A 25-year-old woman presents to her General Practitioner concerned about a red, itchy rash that developed while she was on holiday in Spain. On examination, she has an inflamed eczematous rash on her face, neck, arms and legs, with a few blisters. She has sparing of skin in areas that have been covered by her swimwear. She is currently being treated for acne and takes no other regular medications. She has no other known medical conditions.
      Which of the following medications is most likely to have caused this patient’s rash?

      Your Answer: Oral lymecycline

      Explanation:

      Understanding Photosensitivity and Acne Treatments

      Photosensitivity is a common side-effect of certain medications used to treat acne. This abnormal reaction to ultraviolet (UV) radiation can cause a rash, particularly when exposed to UVA rays. Primary photosensitive conditions include polymorphic light eruption or solar urticaria, while secondary photosensitivity may be caused by medications such as tetracyclines or retinoids, or exposure to psoralens released by plants.

      Lymecycline, a tetracycline antibiotic commonly used to treat acne, is known to cause photosensitivity. Oral erythromycin, a macrolide antibiotic used to treat acne, does not typically cause photosensitive skin reactions. Topical azelaic acid and clindamycin are also used to treat acne but are not known to cause photosensitivity. Topical benzoyl peroxide may cause local skin reactions but is not associated with photosensitivity. It is important to be aware of the potential side-effects of acne treatments and to take precautions to protect the skin from UV radiation.

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      • Dermatology
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  • Question 18 - A 21-year-old woman presents with a two day history of increasing dysuria. During...

    Correct

    • A 21-year-old woman presents with a two day history of increasing dysuria. During examination, inflamed blisters are observed on the outer labia.
      What is the most suitable treatment option?

      Your Answer: Aciclovir

      Explanation:

      Understanding Genital Herpes and Treatment Options

      Genital herpes is a sexually transmitted infection caused by the herpes simplex viruses (HSV-1 or HSV-2). It presents as clusters of papules and vesicles on the outer genitals in both men and women, usually appearing 4-7 days after sexual exposure to HSV for the first time. Unfortunately, there is no cure for genital herpes, but treatment with aciclovir can reduce the duration of symptoms. Other treatment options include antibiotics like azithromycin and clindamycin for bacterial infections, antifungal agents like fluconazole for fungal infections, and metronidazole for anaerobic bacteria and protozoa. It is important to seek medical attention and start treatment as soon as possible to manage symptoms and prevent transmission to others.

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      • Dermatology
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  • Question 19 - A 28-year-old woman presents with a recurring, intensely itchy rash on the palms...

    Incorrect

    • A 28-year-old woman presents with a recurring, intensely itchy rash on the palms of her hands. She reports that these rashes tend to occur every summer. Despite trying over-the-counter emollients and antihistamines, there has been only marginal improvement. The patient is otherwise healthy with no other medical conditions and does not smoke.

      During examination, bilateral vesicles are observed on the palms and sides of the fingers. The palms appear dry with areas of skin peeling, while the rest of her body is unaffected.

      What is the most probable diagnosis?

      Your Answer: Palmoplantar pustulosis

      Correct Answer: Pompholyx eczema

      Explanation:

      Palmoplantar pustulosis is often accompanied by psoriasis on other areas of the body and is strongly linked to smoking. Unlike pompholyx eczema, the connection to high temperatures and humidity is not as significant. Scabies, which is caused by the parasite Sarcoptes scabiei, results in severe itching of the hands and web spaces but is typically not a recurring issue. Symptoms include linear burrows and erythematous papules rather than vesicles.

      Understanding Pompholyx Eczema

      Pompholyx eczema, also known as dyshidrotic eczema, is a type of skin condition that affects both the hands and feet. It is often triggered by high temperatures and humidity, such as sweating. The main symptom of pompholyx eczema is the appearance of small blisters on the palms and soles, which can be intensely itchy and sometimes accompanied by a burning sensation. Once the blisters burst, the skin may become dry and crack.

      To manage pompholyx eczema, cool compresses and emollients can be used to soothe the affected areas. Topical steroids may also be prescribed to reduce inflammation and itching. It is important to avoid further irritation by wearing gloves or protective footwear and avoiding exposure to irritants. With proper management, the symptoms of pompholyx eczema can be controlled and minimized.

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      • Dermatology
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  • Question 20 - Which of the following characteristics is least commonly associated with rosacea? ...

    Incorrect

    • Which of the following characteristics is least commonly associated with rosacea?

      Your Answer: Blepharitis

      Correct Answer: Pruritus

      Explanation:

      It is uncommon for pruritus to be present in cases of acne rosacea.

      Understanding Rosacea: Symptoms and Management

      Rosacea, also known as acne rosacea, is a chronic skin condition that has no known cause. It typically affects the nose, cheeks, and forehead, and the first symptom is often flushing. Over time, telangiectasia (visible blood vessels) may appear, followed by persistent redness with papules and pustules. In some cases, rhinophyma (enlarged nose) may develop, and there may be ocular involvement, such as blepharitis. Sunlight can exacerbate symptoms.

      Mild cases of rosacea may be treated with topical metronidazole, while topical brimonidine gel may be used for patients with predominant flushing but limited telangiectasia. More severe cases may require systemic antibiotics like oxytetracycline. Patients are advised to apply high-factor sunscreen daily and use camouflage creams to conceal redness. Laser therapy may be appropriate for those with prominent telangiectasia, and patients with rhinophyma should be referred to a dermatologist.

      Overall, understanding the symptoms and management of rosacea can help individuals manage their condition and improve their quality of life.

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      • Dermatology
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  • Question 21 - A 28-year-old female comes to the clinic with a skin rash under her...

    Correct

    • A 28-year-old female comes to the clinic with a skin rash under her new bracelet. The possibility of a nickel allergy is being considered. What is the most appropriate test to confirm the diagnosis?

      Your Answer: Skin patch test

      Explanation:

      Understanding Nickel Dermatitis

      Nickel dermatitis is a type of allergic contact dermatitis that is commonly caused by exposure to nickel. This condition is an example of a type IV hypersensitivity reaction, which means that it is caused by an immune response to a specific substance. In the case of nickel dermatitis, the immune system reacts to nickel, which is often found in jewelry such as watches.

      To diagnose nickel dermatitis, a skin patch test is typically performed. This involves applying a small amount of nickel to the skin and monitoring the area for any signs of an allergic reaction. Symptoms of nickel dermatitis can include redness, itching, and swelling of the affected area.

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      • Dermatology
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  • Question 22 - A 32-year-old patient with a history of psoriasis complains of redness in the...

    Incorrect

    • A 32-year-old patient with a history of psoriasis complains of redness in the groin and genital region, as well as in the axilla. The patient has previously mentioned a distaste for creams that are messy or difficult to use. What is the best course of treatment?

      Your Answer: Topical calcipotriol

      Correct Answer: Topical steroid

      Explanation:

      Topical steroids are effective in treating flexural psoriasis in this patient.

      NICE recommends a step-wise approach for chronic plaque psoriasis, starting with regular emollients and then using a potent corticosteroid and vitamin D analogue separately, followed by a vitamin D analogue twice daily, and then a potent corticosteroid or coal tar preparation if there is no improvement. Phototherapy, systemic therapy, and topical treatments are also options for management. Topical steroids should be used cautiously and vitamin D analogues may be used long-term. Dithranol and coal tar have adverse effects but can be effective.

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      • Dermatology
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  • Question 23 - A 38-year-old man presents with pruritic, violaceous papules in a polygonal pattern on...

    Incorrect

    • A 38-year-old man presents with pruritic, violaceous papules in a polygonal pattern on the flexor surface of his forearms. Several of these papules have merged to form plaques. What is the probable diagnosis?

      Your Answer: Psoriasis

      Correct Answer: Lichen planus

      Explanation:

      Lichen planus is a rash that appears as purple, itchy, polygonal papules on the flexor surfaces of the body. It is often accompanied by Wickham’s striae on the surface and can also affect the mouth. In contrast, lichen sclerosus is characterized by white, itchy spots that commonly appear on the vulva of older women.

      Understanding Lichen Planus

      Lichen planus is a skin condition that is believed to be caused by an immune response, although the exact cause is unknown. It is characterized by an itchy, papular rash that typically appears on the palms, soles, genitalia, and flexor surfaces of the arms. The rash often has a polygonal shape and a distinctive white-lines pattern on the surface, known as Wickham’s striae. In some cases, new skin lesions may appear at the site of trauma, a phenomenon known as the Koebner phenomenon.

      Oral involvement is common in around 50% of patients, with a white-lace pattern often appearing on the buccal mucosa. Nail changes may also occur, including thinning of the nail plate and longitudinal ridging. Lichenoid drug eruptions can be caused by certain medications, such as gold, quinine, and thiazides.

      The main treatment for lichen planus is potent topical steroids. For oral lichen planus, benzydamine mouthwash or spray is recommended. In more extensive cases, oral steroids or immunosuppression may be necessary.

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      • Dermatology
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  • Question 24 - A toddler is brought to your clinic as the mother has noticed some...

    Correct

    • A toddler is brought to your clinic as the mother has noticed some skin lesions on the child's face. Upon examination, you observe multiple small white papules on the nose. What is the probable diagnosis?

      Your Answer: Milia

      Explanation:

      Milia, which are often found on the face of newborns, are a normal occurrence and can be seen in up to 50% of babies. They typically disappear on their own within a few weeks.

      Understanding Milia: Small, Benign Cysts on the Face

      Milia are small cysts that are filled with keratin and are typically found on the face. These cysts are benign and are not harmful to one’s health. Although they can appear at any age, they are more commonly found in newborns. Milia are often described as small, white bumps that are painless and do not cause any discomfort.

      While the exact cause of milia is unknown, they are thought to occur when dead skin cells become trapped in the skin’s surface. They can also develop as a result of using heavy skin care products or as a side effect of certain medications. In most cases, milia will disappear on their own without any treatment. However, if they persist or become bothersome, a dermatologist may recommend treatment options such as extraction or chemical peels.

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      • Dermatology
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  • Question 25 - A 35-year-old office worker complains of widespread pruritus for the last 2 weeks....

    Correct

    • A 35-year-old office worker complains of widespread pruritus for the last 2 weeks. She has no particular history of note, though she is currently staying with her parents due to financial difficulties. She has noticed the itching is particularly bad at night. On examination, she has several circular erythematous lesions on her arms and legs.
      Given the likely diagnosis, what is the most appropriate first-line treatment option?

      Your Answer: Permethrin cream applied from neck down for 8-14 hours

      Explanation:

      Treatment Options for Scabies Infestation

      Scabies infestation is a common condition that can affect anyone, but those with poor personal hygiene, immunocompromisation, low socioeconomic status, and those working in industrial settings are at higher risk. The first-line treatment for scabies is the application of Permethrin 5% cream from the neck down for 8-14 hours, followed by washing it off. It is important to treat all household contacts simultaneously, even if they are symptom-free. Additionally, all affected linens should be washed and cleaned immediately.

      While 5% Hydrocortisone cream can be applied twice daily to relieve itching, it will not treat the underlying infestation. Similarly, emollient cream can be applied regularly to moisturize the skin, but it will not treat the infestation.

      If Permethrin is not effective, Malathion cream can be used as a second-line treatment. It should be applied from the neck down for 24 hours and then washed off.

      Oral antihistamines can be used to treat the symptomatic itch, but they do not address the underlying infestation. Therefore, it is important to follow the recommended treatment plan and seek medical advice if symptoms persist.

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      • Dermatology
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  • Question 26 - A 42-year-old woman comes to the clinic complaining of itchy, violaceous papules on...

    Incorrect

    • A 42-year-old woman comes to the clinic complaining of itchy, violaceous papules on the flexor aspects of her wrists. She has no significant medical history and has never experienced a similar rash before. Based on the probable diagnosis, what other symptom is she most likely to exhibit?

      Your Answer: Onycholysis

      Correct Answer: Mucous membrane involvement

      Explanation:

      Lichen planus is a skin condition characterized by a rash of purple, itchy, polygonal papules on the flexor surfaces of the body. The affected area may also have Wickham’s striae. Oral involvement is common. In addition, elderly women may experience itchy white spots on the vulva, known as lichen sclerosus. Mucous membrane involvement is also frequently observed in lichen planus.

      Understanding Lichen Planus

      Lichen planus is a skin condition that is believed to be caused by an immune response, although the exact cause is unknown. It is characterized by an itchy, papular rash that typically appears on the palms, soles, genitalia, and flexor surfaces of the arms. The rash often has a polygonal shape and a distinctive white-lines pattern on the surface, known as Wickham’s striae. In some cases, new skin lesions may appear at the site of trauma, a phenomenon known as the Koebner phenomenon.

      Oral involvement is common in around 50% of patients, with a white-lace pattern often appearing on the buccal mucosa. Nail changes may also occur, including thinning of the nail plate and longitudinal ridging. Lichenoid drug eruptions can be caused by certain medications, such as gold, quinine, and thiazides.

      The main treatment for lichen planus is potent topical steroids. For oral lichen planus, benzydamine mouthwash or spray is recommended. In more extensive cases, oral steroids or immunosuppression may be necessary.

    • This question is part of the following fields:

      • Dermatology
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  • Question 27 - A 35-year-old woman comes to the clinic with patchy hair loss on her...

    Incorrect

    • A 35-year-old woman comes to the clinic with patchy hair loss on her scalp, which is well-defined. The hair loss is affecting approximately 25% of her scalp, and she is experiencing significant emotional distress. The doctor suspects alopecia areata. What would be an appropriate course of action for management?

      Your Answer: Autoimmune screen + topical ketoconazole

      Correct Answer: Topical corticosteroid + referral to dermatologist

      Explanation:

      The National Institute for Clinical Excellence updated its guideline for hypertension management in 2011, placing emphasis on the use of ambulatory blood pressure monitoring (ABPM) to confirm hypertension in individuals with elevated clinic readings. ABPM involves taking two measurements per hour during waking hours and using the average of at least 14 measurements to confirm a diagnosis of hypertension. Secondary causes of hypertension should be investigated in patients under 40 without traditional risk factors, those with other symptoms of secondary causes, and those with resistant hypertension. Hyperaldosteronism is the most common cause of secondary hypertension, and a trial of spironolactone may be used for both therapeutic and diagnostic purposes. Drug treatment for essential hypertension involves ACE inhibitors for those under 55 and calcium channel blockers for those over 55 or of black African or Caribbean origin. Step 2 involves using both ACE inhibitors and calcium channel blockers, while step 3 adds a thiazide-like diuretic. Further diuretics, beta-blockers, or alpha blockers may be considered in step 4, with expert advice sought.

      NICE released updated guidelines in 2019 for the management of hypertension, building on previous guidelines from 2011. These guidelines aimed to classify hypertension into stages and recommend the use of ambulatory blood pressure monitoring (ABPM) and home blood pressure monitoring (HBPM) to accurately diagnose hypertension. This is important because some patients experience white coat hypertension, where their blood pressure rises in a clinical setting, leading to potential overdiagnosis of hypertension. ABPM and HBPM allow for a more accurate assessment of a patient’s overall blood pressure and can prevent overdiagnosis.

      NICE recommends measuring blood pressure in both arms when considering a diagnosis of hypertension and repeating measurements if there is a difference of more than 20 mmHg between arms. If the blood pressure is >= 140/90 mmHg, NICE suggests offering ABPM or HBPM to confirm the diagnosis. If the blood pressure is >= 180/120 mmHg, referral for specialist assessment is recommended if there are signs of retinal haemorrhage or papilloedema or life-threatening symptoms. If target organ damage is identified, antihypertensive drug treatment may be started immediately.

      ABPM involves taking at least 2 measurements per hour during the person’s usual waking hours and using the average value of at least 14 measurements. If ABPM is not tolerated, HBPM should be offered. HBPM involves taking two consecutive measurements at least 1 minute apart, twice daily for at least 4 days, and using the average value of all remaining measurements.

      Interpreting the results of ABPM/HBPM is important for determining treatment. If the average blood pressure is >= 135/85 mmHg (stage 1 hypertension), treatment may be considered for patients under 80 years of age with target organ damage, established cardiovascular disease, renal disease, diabetes, or a 10-year cardiovascular risk equivalent to 10% or greater. In 2019, NICE also recommended considering antihypertensive drug treatment for adults under 60 with stage 1 hypertension and an estimated 10-year risk below 10%. If the average blood pressure is >= 150/95 mmHg (stage 2 hypertension), drug treatment should be offered regardless of age.

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      • Dermatology
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  • Question 28 - During your assessment of a 55-year-old patient admitted to the medical ward, you...

    Incorrect

    • During your assessment of a 55-year-old patient admitted to the medical ward, you observe a rash on her legs. The rash has a lace-like pattern in a purple color and does not disappear when touched. It is located on the lower legs. The patient has a medical history of systemic lupus erythematosus and reports experiencing this rash on and off in the past, often triggered by cold weather. What is the most probable diagnosis for this rash?

      Your Answer: Erythema nodosum

      Correct Answer: Livedo reticularis

      Explanation:

      Understanding Livedo Reticularis

      Livedo reticularis is a skin condition characterized by a purplish, non-blanching, reticulated rash. This occurs when the capillaries become obstructed, leading to swollen venules. The most common cause of this condition is idiopathic, meaning that the cause is unknown. However, it can also be caused by various underlying medical conditions such as polyarteritis nodosa, systemic lupus erythematosus, cryoglobulinaemia, antiphospholipid syndrome, Ehlers-Danlos Syndrome, and homocystinuria.

      It is important to note that livedo reticularis is not a disease in itself, but rather a symptom of an underlying condition.

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      • Dermatology
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  • Question 29 - Which of the following skin conditions is not linked to diabetes mellitus? ...

    Incorrect

    • Which of the following skin conditions is not linked to diabetes mellitus?

      Your Answer: Vitiligo

      Correct Answer: Sweet's syndrome

      Explanation:

      Sweet’s syndrome is a condition associated with acute myeloid leukemia, also known as acute febrile neutrophilic dermatosis, but not with diabetes mellitus.

      Skin Disorders Linked to Diabetes

      Diabetes mellitus is a chronic metabolic disorder that affects various organs in the body, including the skin. Several skin disorders are associated with diabetes, including necrobiosis lipoidica, infections such as candidiasis and staphylococcal, neuropathic ulcers, vitiligo, lipoatrophy, and granuloma annulare. Necrobiosis lipoidica is characterized by shiny, painless areas of yellow, red, or brown skin, typically on the shin, and is often associated with surrounding telangiectasia. Infections such as candidiasis and staphylococcal can also occur in individuals with diabetes. Neuropathic ulcers are a common complication of diabetes, and vitiligo and lipoatrophy are also associated with the condition. Granuloma annulare is a papular lesion that is often slightly hyperpigmented and depressed centrally, but recent studies have not confirmed a significant association between diabetes mellitus and this skin disorder. It is important for individuals with diabetes to be aware of these potential skin complications and to seek medical attention if they notice any changes in their skin.

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      • Dermatology
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  • Question 30 - A 26-year-old patient comes in with lesions on their lower abdomen that have...

    Correct

    • A 26-year-old patient comes in with lesions on their lower abdomen that have been present for six weeks. At first, there was only one lesion, but more have appeared since then. During the examination, around 10 raised lesions with an umbilicated appearance, each around 1-2 mm in diameter, are observed. What is the most probable diagnosis?

      Your Answer: Molluscum contagiosum

      Explanation:

      Molluscum contagiosum is typically observed in children, but the following is a classical depiction of the condition.

      Understanding Molluscum Contagiosum

      Molluscum contagiosum is a viral skin infection that is commonly seen in children, particularly those with atopic eczema. It is caused by the molluscum contagiosum virus and can be transmitted through direct contact or contaminated surfaces. The infection presents as pinkish or pearly white papules with a central umbilication, which can appear anywhere on the body except for the palms of the hands and soles of the feet. In children, lesions are commonly seen on the trunk and in flexures, while in adults, sexual contact may lead to lesions developing on the genitalia, pubis, thighs, and lower abdomen.

      While molluscum contagiosum is a self-limiting condition that usually resolves within 18 months, it is important to avoid sharing towels, clothing, and baths with uninfected individuals to prevent transmission. Scratching the lesions should also be avoided, and treatment may be considered if the itch is problematic. However, treatment is not usually recommended, and if necessary, simple trauma or cryotherapy may be used. In some cases, referral may be necessary, such as for individuals who are HIV-positive with extensive lesions or those with eyelid-margin or ocular lesions and associated red eye.

      Overall, understanding molluscum contagiosum and taking appropriate precautions can help prevent transmission and alleviate symptoms.

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      • Dermatology
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