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Question 1
Incorrect
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A 72-year-old retired teacher with advanced ovarian cancer is reviewed at home by her General Practitioner (GP). Her daughter requested a home visit due to significant deterioration in her health over the past few days, and she is concerned that she can no longer meet her healthcare needs at home without assistance.
During the consultation, the GP discusses considering hospice care for the patient.
To be appropriate for hospice care management, a patient must:Your Answer: Have uncontrolled pain
Correct Answer: No longer be seeking curative treatment
Explanation:Myths about Hospice Care: Debunked
Hospice care is often misunderstood, leading to misconceptions about who can receive it and what it entails. Here are some common myths about hospice care debunked:
Myth #1: Hospice care is only for patients with terminal cancer.
Fact: Patients with any terminal diagnosis can seek hospice care, not just those with cancer. Commonly, patients with chronic lung disease, dementia, and neurodegenerative disorders benefit from hospice care.Myth #2: Patients must be bed-bound to receive hospice care.
Fact: Mobility status does not affect admission to hospice. Patients in hospices often take part in activities and may be fully mobile.Myth #3: Patients must have a ‘do not resuscitate’ (DNACPR) decision to receive hospice care.
Fact: Although most patients will have a DNACPR decision in a hospice, this is not a requirement.Myth #4: Patients must have uncontrolled pain to receive hospice care.
Fact: While some patients may be admitted to a hospice for pain control, hospices are able to treat other symptoms, and pain control can be addressed in other settings, depending on the patient’s needs and wishes.Hospice care and palliative care both focus on quality of life care for the patient and address adjustment to illness and end-of-life issues. Both forms of care address pain and symptom control issues for patients. However, hospice care is for patients who are no longer actively seeking curative treatment and have a terminal diagnosis with a life expectancy of 6 months or less. In contrast, for palliative care treatment, patients may still be undergoing aggressive treatment and do not have to be terminally ill. It is important to understand the facts about hospice care to make informed decisions about end-of-life care.
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This question is part of the following fields:
- Palliative Care
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Question 2
Correct
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An 85-year-old man with renal failure attends hospital for dialysis three times per week. He presents to the Emergency Department with acute shortness of breath and is found to have suffered from a large anterior myocardial infarct. The medical team decides to discuss a DNACPR decision with him. When is it appropriate to consider a DNACPR order?
Your Answer: Where successful CPR is likely to be followed by a length and quality of life that are not in the best interests of the patient to sustain
Explanation:When to Consider DNACPR Orders: Factors to Consider
Deciding whether or not to perform cardiopulmonary resuscitation (CPR) on a patient can be a difficult decision. While CPR can be life-saving, it is not always the best course of action. Here are some factors to consider when deciding whether to issue a Do Not Attempt Cardiopulmonary Resuscitation (DNACPR) order:
1. Length and quality of life: If successful CPR is likely to result in a poor quality of life for the patient, it may not be in their best interests to sustain it.
2. Patient wishes: If a mentally competent patient has expressed a desire not to receive CPR, their wishes should be respected.
3. Likelihood of success: If the patient’s condition indicates that CPR is unlikely to be successful, it may not be worth attempting.
4. Shockable rhythms: If the patient is in ventricular fibrillation or ventricular tachycardia, CPR may be successful and should be attempted.
5. Cost and resources: The cost and availability of facilities should not be a factor in deciding whether to perform CPR.
6. Family wishes: If the patient is mentally competent, their family cannot make decisions regarding resuscitation.
7. Age: Age alone should not be a factor in deciding whether to issue a DNACPR order, as a fit and healthy older person may have a good chance of survival.
Considering these factors can help healthcare professionals make informed decisions about whether or not to perform CPR on a patient.
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This question is part of the following fields:
- Palliative Care
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Question 3
Incorrect
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An 80-year-old nursing home resident with end-stage dementia has an acute bowel obstruction; she is not a suitable candidate for surgical intervention.
Which of the following medications may be most effective in reducing her discomfort?Your Answer: Dexamethasone
Correct Answer: Loperamide hydrochloride
Explanation:Medications for Managing Bowel Obstruction in End-of-Life Care
Bowel obstruction during end-of-life care can be managed without surgery or nasogastric tube placement. Loperamide hydrochloride, an antidiarrhoeal medication, can provide relief by reducing bowel motility when used with an opiate analgesic. Ondansetron, an antiemetic, can treat nausea but may cause constipation by slowing gastric stasis. Dexamethasone can alleviate bowel discomfort by reducing inflammation and oedema caused by a tumour obstructing the bowel. Lorazepam can help alleviate distress or anxiety caused by symptoms, but it does not improve them. Paracetamol is a weak analgesic and is unlikely to relieve discomfort in this case.
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This question is part of the following fields:
- Palliative Care
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Question 4
Correct
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An 82-year-old woman with metastatic breast cancer is referred to the Palliative Care team for assessment and planning of further care.
Which of the following best describes the role of palliative care?Your Answer: Symptom control
Explanation:The Focus of Palliative Care: Symptom Control
Palliative care is a specialized medical care that aims to improve the quality of life of patients with serious or life-threatening illnesses. The primary focus of palliative care is on anticipating, preventing, diagnosing, and treating symptoms experienced by patients, regardless of their diagnosis. Unlike hospice care, palliative care does not depend on prognosis.
The goal of palliative care is to improve the quality of life for both the patient and their family. Palliative care aims to treat symptoms rather than modify the disease, and it is not focused on curative or life-prolonging care. Pain management is an important aspect of palliative care, but the control of all disease symptoms is the best answer. Overall, the focus of palliative care is on symptom control to improve the quality of life for patients and their families.
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This question is part of the following fields:
- Palliative Care
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Question 5
Incorrect
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A 67-year-old woman attending Oncology has metastatic breast cancer with bony metastases in her pelvis and femur. She has hip pain at rest, not relieved by paracetamol and naproxen.
Which of the following analgesic options would be most specific for metastatic bone pain?Your Answer: Oral gabapentin
Correct Answer: Intravenous ibandronate
Explanation:Treatment Options for Metastatic Bone Pain
Metastatic bone pain can be a challenging symptom to manage in patients with advanced cancer. Here are some treatment options:
Intravenous Ibandronate: This bisphosphonate is administered intravenously and is effective in controlling pain from bony metastases.
Oral Gabapentin: Gabapentin is a medication used to treat neuropathic pain.
Oral Oxycontin: Oxycontin is an opioid that can relieve pain, but it is not specific to metastatic bone pain.
Oral Tramadol: Tramadol is an analgesic medication that can be taken orally, but according to NICE guidelines, ibandronic acid is the recommended treatment for metastatic bony pain.
Intravenous Morphine Sulfate: Intravenous morphine is not the preferred medication in palliative care, as it can be difficult to obtain intravenous access in frail patients. Subcutaneous delivery may be an alternative option.
Overall, the choice of treatment will depend on the individual patient’s needs and preferences, as well as the severity of their pain. A multidisciplinary approach involving healthcare professionals and the patient’s family can help to ensure that the patient receives the best possible care.
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This question is part of the following fields:
- Palliative Care
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Question 6
Correct
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A 67-year-old man on palliative chemotherapy for advanced lung cancer is brought to the Emergency Department by his wife as he has been feeling increasingly weak and lethargic over the past few days. His arterial blood gas results are below:
Investigation Result Normal range
pH 7.51 7.35–7.45
Partial pressure of oxygen (PaO2) 11.7 kPa > 11 kPa
Partial pressure of carbon dioxide (PaCO2) 5.5 kPa 4.7–6.0 kPa
Bicarbonate (HCO3−) 29 mEq/l 22–26 mEq/l
Base excess +3 -2 to +2
Which of the following is most likely to cause this result?Your Answer: Vomiting
Explanation:Causes of Acid-Base Imbalances: Explanation and Examples
Vomiting: When a patient’s arterial blood gas shows an uncompensated metabolic alkalosis, it suggests an acute cause such as vomiting. Vomiting causes a loss of stomach acid, resulting in fewer H+ ions to bind to HCO3-, leading to more free HCO3- and resulting in a metabolic alkalosis.
Aspirin Overdose: An aspirin overdose typically causes an initial respiratory alkalosis followed by a metabolic acidosis with a raised anion gap. The respiratory alkalosis is the result of direct stimulation of the medulla, while the metabolic acidosis is caused by an accumulation of lactic acid due to an uncoupling of oxidative phosphorylation.
Anxiety: Hyperventilation associated with anxiety would cause a respiratory alkalosis. This is due to ‘blowing off’ carbon dioxide through hyperventilation, resulting in a decreased PaCO2 in the blood and an increased ratio of HCO3− to PaCO2, raising the pH and resulting in alkalosis.
Pulmonary Embolism: A pulmonary embolism would cause a respiratory alkalosis, usually accompanied by hypoxia or type I respiratory failure.
Respiratory Depression: Respiratory depression would cause a respiratory acidosis. Hypoventilation means that less carbon dioxide is blown off, resulting in an increase in PaCO2 in the blood, which decreases the pH.
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This question is part of the following fields:
- Palliative Care
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Question 7
Incorrect
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During a Monday lunchtime home visit, you encounter a 72-year-old patient with metastatic colon cancer who has been experiencing a decline in health over the past 2 months. The patient has extensive disease with liver and peritoneal metastatic deposits and also suffers from type II diabetes mellitus and moderately severe chronic obstructive pulmonary disease (COPD). To manage her pain, she takes ibuprofen 400 mg three times daily (tid), paracetamol 1 g four times daily (qds), morphine sulfate modified-release tablets (MST) 30 mg twice daily (bd), and Oramorph® 10 mg as required (prn). However, her abdominal pain has worsened over the weekend, and she has required three doses of Oramorph® per day in addition to her other analgesia. Although the dose is effective, the pain returns after about 2-3 hours. The patient is able to consume small amounts of food and fluid but appears to be in poor health with jaundice and quick, shallow breathing. What is the most appropriate treatment for her pain?
Your Answer: Commence a continuous subcutaneous infusion of morphine sulfate 45 mg per 24 h, with subcutaneous morphine for breakthrough pain
Correct Answer: Increase her MST dose to 45 mg bd and Oramorph® dose to 15 mg prn
Explanation:Managing Pain in a Palliative Care Patient: Dosage Adjustments and Adjuncts
When managing pain in a palliative care patient, it is important to consider the appropriate dosage adjustments and adjuncts to provide effective pain relief. In the given scenario, the patient was taking 60 mg of morphine (as MST) and required another 30 mg of Oramorph® per day for breakthrough pain, resulting in a total daily dose of 90 mg. To address uncontrolled pain, the MST dose was increased to 45 mg bd and the Oramorph® dose was adjusted to 15 mg prn, with the breakthrough dose being one-sixth of the total daily dose.
While dexamethasone may be considered as an adjunct for liver capsule pain, amitriptyline is not indicated for neuropathic pain in this case. Increasing the dose of ibuprofen is also unlikely to provide significant pain relief. Instead, it is advisable to stick to oral morphine and adjust the dosage accordingly.
In some cases, a continuous subcutaneous infusion of morphine sulfate may be necessary, but it is preferable to use the oral route when possible to reduce the risk of infection and improve patient comfort. Overall, careful consideration of dosage adjustments and adjuncts can help provide effective pain relief for palliative care patients.
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This question is part of the following fields:
- Palliative Care
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Question 8
Incorrect
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A 55-year-old woman presents to the Oncology Ward with vomiting three days after receiving chemotherapy for non-Hodgkin’s lymphoma (NHL). She is also experiencing muscle spasms in her hands and feet and has severe muscle weakness.
The patient’s blood test results are shown below:
Investigation Result Normal range
Sodium 144 mmol/l 135–145 mmol/l
Potassium 6.7 mmol/l 3.5–5.0 mmol/l
Uric acid 600 µmol/l 140–360 µmol/l
Creatinine 168 µmol/l 68–98 µmol/l
Calcium 1.60 mmol/l 2.05–2.60 mmol/l
Phosphate 2.4 mmol/l 0.8–1.50 mmol/l
Creatine kinase 65 U/l 25–200 U/l
What is the most likely diagnosis?Your Answer: Chemotherapy-induced vomiting
Correct Answer: Tumour-lysis syndrome (TLS)
Explanation:Understanding Tumour-Lysis Syndrome: A Serious Complication of Chemotherapy
Tumour-lysis syndrome (TLS) is a potentially life-threatening complication of chemotherapy, most commonly seen in patients with lymphomas and leukaemias. It occurs when tumour cells are destroyed, releasing their contents into the bloodstream and causing severe metabolic derangement. Symptoms may include vomiting and electrolyte imbalances, such as muscle spasms due to hypocalcaemia. TLS can lead to acute renal failure, seizures, cardiac arrhythmias, and even death.
To prevent TLS, patients are assessed for their risk before chemotherapy and may be given prophylaxis with medications such as allopurinol or rasburicase. Laboratory TLS in adults are defined by specific criteria for uric acid, potassium, phosphate, and calcium levels.
Other potential causes of the patient’s symptoms, such as dehydration, chemotherapy-induced vomiting, rhabdomyolysis, and sepsis, were ruled out as they did not explain the marked electrolyte imbalances seen in TLS. It is important for healthcare professionals to recognize and manage TLS promptly to prevent serious complications and improve patient outcomes.
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This question is part of the following fields:
- Palliative Care
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Question 9
Correct
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A 60-year-old man visits his GP with metastatic lung cancer. He reports taking 1 g of paracetamol four times daily and codeine 60 mg four times daily, but is still experiencing pain. What is the best course of action for managing his pain?
Your Answer: Stop codeine and start morphine sulphate modified release 15 mg twice daily with view to titrate dose
Explanation:Choosing the Right Opioid for Inadequate Pain Control
Explanation:
When a patient has inadequate pain control on a weak opiate and non-opiate combination, it’s important to consider switching to a strong opiate. However, choosing the right opioid requires careful consideration of the patient’s needs and potential risks.
One option is to stop codeine and start morphine sulphate modified release at a low dose, with the intention of titrating the dose slowly to reduce the risk of overdose. Short-acting morphine can be used for breakthrough pain, and the dose of the modified release morphine can be adjusted as needed.
On the other hand, switching to co-codamol or dihydrocodeine may not provide sufficient pain relief for this patient. Co-codamol at the same dose as the current codeine regimen would not improve pain control, while dihydrocodeine may require higher doses than morphine.
Finally, tramadol is a weak opioid and may not be effective for this patient’s level of pain. Instead, starting with a low dose of morphine and titrating slowly may be the best option for achieving adequate pain control while minimizing the risk of adverse effects.
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This question is part of the following fields:
- Palliative Care
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Question 10
Correct
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A 79-year-old man with metastatic lung cancer is in hospice care. He is becoming weaker with loud audible breath sounds and a respiratory rate of 25 breaths per minute. He has a very weak cough.
Which of the following medications may be of most benefit?Your Answer: Subcutaneous infusion of hyoscine hydrobromide
Explanation:Managing Respiratory Secretions in Palliative Care: Medications and Interventions
Towards the end of life, patients may experience difficulty in clearing respiratory secretions due to underlying disease and a weakening cough reflex. This can cause discomfort and distress. There are several medications and interventions that can be used to manage respiratory secretions in palliative care.
Subcutaneous infusion of hyoscine hydrobromide is appropriate for patients with a weak cough. This anticholinergic medication helps dry up secretions and is recommended at a dose of 400 micrograms every 4 hours by subcutaneous injection, or more if required.
Saline nebulisers can be used to loosen secretions in patients who can still cough strongly.
Intravenous dexamethasone has no role in treating noisy respiratory secretions at the end of life.
Low-dose morphine can be used to treat shortness of breath in palliative care, but other medications would be used first for patients suffering from secretions.
Chest physiotherapy, including chest clearance exercises, can be useful for patients who are unable to cough up secretions, but is unlikely to benefit patients who are able to cough.
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This question is part of the following fields:
- Palliative Care
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