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Question 1
Correct
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A 68-year-old woman presents to the respiratory clinic for a follow-up of her COPD. She informs the healthcare provider that she has quit smoking, resulting in fewer COPD exacerbations, none of which required hospitalization. However, she has observed a slight increase in her weight and swelling in her ankles.
During the physical examination, the patient's weight is noted to be 76kg, up from her previous weight of 72kg. The healthcare provider listens to her heart and lungs and detects normal breath and heart sounds. The patient has bilateral edema that extends up to her mid-calves.
What other examination findings may be evident, given the probable diagnosis?Your Answer: Smooth hepatomegaly
Explanation:The patient’s symptoms suggest that they have developed cor pulmonale due to COPD, resulting in right-sided heart failure. On examination, signs of fluid congestion such as peripheral edema, raised jugular venous pressure (JVP), ascites, and hepatomegaly may be present. Therefore, the most likely finding would be an enlarged liver with a firm, smooth, tender, and pulsatile edge.
Caput medusae, which refers to the swelling of superficial veins in the epigastric area, is unlikely to occur in a new presentation of cor pulmonale.
Narrow pulse pressure is a characteristic of aortic stenosis, which causes left ventricular dysfunction. However, this patient only shows signs of right-sided heart failure.
A palpable thrill, which indicates turbulent flow across a heart valve, may be felt in severe valvular disease that causes left ventricular dysfunction. Murmurs are often present in valvular disease, but not in this patient’s case.
Reverse splitting of the second heart sound may occur in aortic stenosis or left bundle branch block, which can cause left ventricular dysfunction.
Understanding Hepatomegaly and Its Common Causes
Hepatomegaly refers to an enlarged liver, which can be caused by various factors. One of the most common causes is cirrhosis, which can lead to a decrease in liver size in later stages. In this case, the liver is non-tender and firm. Malignancy, such as metastatic spread or primary hepatoma, can also cause hepatomegaly. In this case, the liver edge is hard and irregular. Right heart failure can also lead to an enlarged liver, which is firm, smooth, and tender. It may even be pulsatile.
Aside from these common causes, hepatomegaly can also be caused by viral hepatitis, glandular fever, malaria, abscess (pyogenic or amoebic), hydatid disease, haematological malignancies, haemochromatosis, primary biliary cirrhosis, sarcoidosis, and amyloidosis.
Understanding the causes of hepatomegaly is important in diagnosing and treating the underlying condition. Proper diagnosis and treatment can help prevent further complications and improve overall health.
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This question is part of the following fields:
- Gastrointestinal System
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Question 2
Correct
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A 65-year-old man who is a heavy smoker complains of dyspepsia. Upon testing, he is diagnosed with helicobacter pylori infection. Later, he experiences an episode of haematemesis and faints. Which blood vessel is most likely responsible for this?
Your Answer: Gastroduodenal artery
Explanation:It is probable that he has a duodenal ulcer located at the back. Such ulcers can penetrate the gastroduodenal artery and result in significant bleeding. While gastric ulcers can also invade vessels, they are not typically associated with major bleeding of this type.
The Gastroduodenal Artery: Supply and Path
The gastroduodenal artery is responsible for supplying blood to the pylorus, proximal part of the duodenum, and indirectly to the pancreatic head through the anterior and posterior superior pancreaticoduodenal arteries. It commonly arises from the common hepatic artery of the coeliac trunk and terminates by bifurcating into the right gastroepiploic artery and the superior pancreaticoduodenal artery.
To better understand the relationship of the gastroduodenal artery to the first part of the duodenum, the stomach is reflected superiorly in an image sourced from Wikipedia. This artery plays a crucial role in providing oxygenated blood to the digestive system, ensuring proper functioning and health.
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This question is part of the following fields:
- Gastrointestinal System
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Question 3
Correct
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A 78-year-old man is assessed by his GP at his assisted living facility. The nursing staff reports that he has been experiencing frequent loose stools for the past few days and appears to be holding his stomach in pain. There are no signs of dehydration.
The patient has a medical history of advanced vascular dementia and has had multiple bacterial chest infections recently. He is allergic to penicillin.
The GP requests a stool sample, conducts blood tests, and prescribes oral vancomycin for the patient.
What are the expected findings on stool microscopy?Your Answer: Gram-positive bacilli
Explanation:The causative organism in pseudomembranous colitis following recent broad-spectrum antibiotic use is Clostridium difficile, a gram-positive bacillus. This woman’s clinical presentation is consistent with C. diff infection, as she has experienced multiple episodes of loose stool with abdominal pain and has risk factors such as residing in a care home and recent antibiotic use for chest infections. While gram-negative comma-shaped bacteria like Vibrio cholerae can cause cholera, it is not found in the UK and is therefore unlikely to be the cause here. Gram-negative rods like Escherichia coli or Campylobacter jejuni can cause diarrhoeal illnesses, but are more associated with bloody diarrhoea and food poisoning, which do not match this woman’s symptoms. Gram-positive rods like Bacillus cereus can cause vomiting or diarrhoeal illness from contaminated food, but antibiotics are not beneficial and vancomycin would not be needed. Given the woman’s risk factors and symptoms, C. diff is the most likely cause.
Clostridium difficile is a type of bacteria that is commonly found in hospitals. It produces a toxin that can damage the intestines and cause a condition called pseudomembranous colitis. This bacteria usually develops when the normal gut flora is disrupted by broad-spectrum antibiotics, with second and third generation cephalosporins being the leading cause. Other risk factors include the use of proton pump inhibitors. Symptoms of C. difficile infection include diarrhea, abdominal pain, and a raised white blood cell count. The severity of the infection can be determined using the Public Health England severity scale.
To diagnose C. difficile infection, a stool sample is tested for the presence of the C. difficile toxin. Treatment involves reviewing current antibiotic therapy and stopping antibiotics if possible. For a first episode of infection, oral vancomycin is the first-line therapy for 10 days, followed by oral fidaxomicin as second-line therapy and oral vancomycin with or without IV metronidazole as third-line therapy. Recurrent infections may require different treatment options, such as oral fidaxomicin within 12 weeks of symptom resolution or oral vancomycin or fidaxomicin after 12 weeks of symptom resolution. In life-threatening cases, oral vancomycin and IV metronidazole may be used, and surgery may be considered with specialist advice. Other therapies, such as bezlotoxumab and fecal microbiota transplant, may also be considered for preventing recurrences in certain cases.
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This question is part of the following fields:
- Gastrointestinal System
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Question 4
Correct
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A slender 65-year-old woman complains of sudden onset of abdominal pain. The pain is diffuse but most severe in the upper abdomen. During examination, she is intentionally tensing her muscles and experiences extreme tenderness upon palpation. She has a medical history of left hip osteoarthritis, which she is treating with pain medication. Your coworker requests that you examine her chest x-ray while standing. What is the probable result in this situation?
Your Answer: Free air under the diaphragm
Explanation:It is probable that this woman is suffering from a perforated peptic ulcer, given her medical history of osteoarthritis and use of analgesics (possibly NSAIDs) which can lead to ulcer development. The presence of free air under the diaphragm on an upright chest x-ray is a typical indication of a perforated organ, indicating the presence of pneumoperitoneum (air in the peritoneal cavity).
Exam Features of Conditions Causing Abdominal Pain
Abdominal pain can be caused by various conditions, and it is important for medical students to be familiar with the characteristic exam features of each condition. Peptic ulcer disease, for example, can present with epigastric pain that is either relieved or worsened by eating, depending on whether it is a duodenal or gastric ulcer. Appendicitis, on the other hand, typically starts with pain in the central abdomen before localizing to the right iliac fossa. Other conditions, such as acute pancreatitis, biliary colic, diverticulitis, and intestinal obstruction, also have their own unique exam features.
It is worth noting that some conditions causing abdominal pain may not be as common or may have unusual presentations. For instance, acute coronary syndrome, diabetic ketoacidosis, pneumonia, acute intermittent porphyria, and lead poisoning can all cause abdominal pain, but they are not typically associated with it. Therefore, it is important for medical students to have a broad understanding of the possible causes of abdominal pain and to be able to recognize the characteristic exam features of each condition.
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This question is part of the following fields:
- Gastrointestinal System
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Question 5
Correct
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A 50-year-old man has metastatic adenocarcinoma of the colon that has spread throughout his body. Which of the following tumor markers is expected to be elevated?
Your Answer: Carcinoembryonic antigen
Explanation:Using CEA as a screening tool for colonic cancer is not justifiable. While it is true that CEA levels are elevated in colonic cancer, this is also the case in non-malignant conditions such as cirrhosis and colitis. Additionally, the highest levels of CEA are typically seen in cases of metastatic disease. Therefore, CEA should not be used to monitor colitis patients for the development of colonic cancer. This information is supported by a study published in the BMJ in 2009.
Diagnosis and Staging of Colorectal Cancer
Diagnosis of colorectal cancer is typically done through a colonoscopy, which is considered the gold standard as long as it is complete and provides good mucosal visualization. Other options for diagnosis include double-contrast barium enema and CT colonography. Once a malignant diagnosis is made, patients will undergo staging using chest, abdomen, and pelvic CT scans. Patients with rectal cancer will also undergo evaluation of the mesorectum with pelvic MRI scanning. For examination purposes, the Dukes and TNM systems are preferred.
Tumour Markers in Colorectal Cancer
Carcinoembryonic antigen (CEA) is the main tumour marker in colorectal cancer. While not all tumours secrete CEA, it is still used as a marker for disease burden and is once again being used routinely in follow-up. However, it is important to note that CEA levels may also be raised in conditions such as IBD.
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This question is part of the following fields:
- Gastrointestinal System
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Question 6
Incorrect
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A 55-year-old male visits his doctor complaining of abdominal pain, occasional vomiting of blood, and significant weight loss over the past two months. After undergoing a gastroscopy, which reveals multiple gastric ulcers and thickened gastric folds, the doctor suspects the presence of a gastrinoma and orders a secretin stimulation test (which involves administering exogenous secretin) to confirm the diagnosis.
What is the mechanism by which this administered hormone works?Your Answer: Stimulates gastric acid secretion
Correct Answer: Decreases gastric acid secretion
Explanation:Secretin is a hormone that is released by the duodenum in response to acidity. Its primary function is to decrease gastric acid secretion. It should be noted that the secretin stimulation test involves administering exogenous secretin, which paradoxically causes an increase in gastrin secretion. Secretin does not play a role in carbohydrate digestion, stimulation of gallbladder contraction, stimulation of gastric acid secretion (which is the function of gastrin), or stimulation of pancreatic enzyme secretion (which is another function of CCK).
Overview of Gastrointestinal Hormones
Gastrointestinal hormones play a crucial role in the digestion and absorption of food. These hormones are secreted by various cells in the stomach and small intestine in response to different stimuli such as the presence of food, pH changes, and neural signals.
One of the major hormones involved in food digestion is gastrin, which is secreted by G cells in the antrum of the stomach. Gastrin increases acid secretion by gastric parietal cells, stimulates the secretion of pepsinogen and intrinsic factor, and increases gastric motility. Another hormone, cholecystokinin (CCK), is secreted by I cells in the upper small intestine in response to partially digested proteins and triglycerides. CCK increases the secretion of enzyme-rich fluid from the pancreas, contraction of the gallbladder, and relaxation of the sphincter of Oddi. It also decreases gastric emptying and induces satiety.
Secretin is another hormone secreted by S cells in the upper small intestine in response to acidic chyme and fatty acids. Secretin increases the secretion of bicarbonate-rich fluid from the pancreas and hepatic duct cells, decreases gastric acid secretion, and has a trophic effect on pancreatic acinar cells. Vasoactive intestinal peptide (VIP) is a neural hormone that stimulates secretion by the pancreas and intestines and inhibits acid secretion.
Finally, somatostatin is secreted by D cells in the pancreas and stomach in response to fat, bile salts, and glucose in the intestinal lumen. Somatostatin decreases acid and pepsin secretion, decreases gastrin secretion, decreases pancreatic enzyme secretion, and decreases insulin and glucagon secretion. It also inhibits the trophic effects of gastrin and stimulates gastric mucous production.
In summary, gastrointestinal hormones play a crucial role in regulating the digestive process and maintaining homeostasis in the gastrointestinal tract.
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This question is part of the following fields:
- Gastrointestinal System
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Question 7
Correct
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A 23-year-old woman presents to her GP with a 3-month history of fatigue, breathlessness on exertion, skin pallor, and a swollen, painful tongue. She has also been experiencing bloating, diarrhoea, and stomach pain.
On examination her respiratory rate was 18/min at rest, oxygen saturation 99%, blood pressure 120/80 mmHg and temperature 37.1ºC. Her abdomen was generally tender and distended.
The results of a blood test are as follows:
Hb 90 g/L Male: (135-180)
Female: (115 - 160)
Ferritin 8 ng/mL (20 - 230)
Vitamin B12 120 ng/L (200 - 900)
Folate 2.0 nmol/L (> 3.0)
What investigation would be most likely to determine the diagnosis?Your Answer: Tissue transglutaminase antibodies (anti-TTG) and total immunoglobulin A levels (total IgA)
Explanation:Understanding Coeliac Disease
Coeliac disease is an autoimmune disorder that affects approximately 1% of the UK population. It is caused by sensitivity to gluten, a protein found in wheat, barley, and rye. Repeated exposure to gluten leads to villous atrophy, which causes malabsorption. Coeliac disease is associated with various conditions, including dermatitis herpetiformis and autoimmune disorders such as type 1 diabetes mellitus and autoimmune hepatitis. It is strongly linked to HLA-DQ2 and HLA-DQ8.
To diagnose coeliac disease, NICE recommends screening patients who exhibit signs and symptoms such as chronic or intermittent diarrhea, failure to thrive or faltering growth in children, persistent or unexplained gastrointestinal symptoms, prolonged fatigue, recurrent abdominal pain, sudden or unexpected weight loss, unexplained anemia, autoimmune thyroid disease, dermatitis herpetiformis, irritable bowel syndrome, type 1 diabetes, and first-degree relatives with coeliac disease.
Complications of coeliac disease include anemia, hyposplenism, osteoporosis, osteomalacia, lactose intolerance, enteropathy-associated T-cell lymphoma of the small intestine, subfertility, and unfavorable pregnancy outcomes. In rare cases, it can lead to esophageal cancer and other malignancies.
The diagnosis of coeliac disease is confirmed through a duodenal biopsy, which shows complete atrophy of the villi with flat mucosa and marked crypt hyperplasia, intraepithelial lymphocytosis, and dense mixed inflammatory infiltrate in the lamina propria. Treatment involves a lifelong gluten-free diet.
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This question is part of the following fields:
- Gastrointestinal System
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Question 8
Correct
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Which of the following genes is not involved in the adenoma-carcinoma sequence of colorectal cancer?
Your Answer: src
Explanation:Additional genes implicated include MCC, DCC, c-yes, and bcl-2.
Colorectal cancer is a prevalent type of cancer in the UK, ranking third in terms of frequency and second in terms of cancer-related deaths. Every year, approximately 150,000 new cases are diagnosed, and 50,000 people die from the disease. The cancer can occur in different parts of the colon, with the rectum being the most common location, accounting for 40% of cases. The sigmoid colon follows closely, with 30% of cases, while the descending colon has only 5%. The transverse colon has 10% of cases, and the ascending colon and caecum have 15%.
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This question is part of the following fields:
- Gastrointestinal System
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Question 9
Correct
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A 40-year-old female comes to the clinic complaining of difficulty swallowing both solid and liquid foods for the past 3 months. She denies any hoarseness of voice but reports having had pneumonia a month ago, which resolved with antibiotics. Upon examination, oesophageal manometry reveals absent peristalsis, increased lower sphincter tone, and incomplete relaxation of the lower sphincter during swallowing.
What is the most probable diagnosis for this patient?Your Answer: Achalasia
Explanation:The classic triad for achalasia includes loss of peristalsis, increased lower sphincter tone, and inadequate relaxation of the lower sphincter, which is evident on manometry. Dysphagia for both solid and liquid is also a common symptom of achalasia.
Unlike achalasia, Barrett’s esophagus does not show any changes on manometry. However, it can be identified through the presence of intestinal metaplasia on endoscopy.
Diffuse esophageal spasm is a motility disorder that does not affect lower esophageal sphincter pressure and relaxation during swallowing. Instead, manometry reveals repetitive high amplitude contractions.
Hiatus hernia is typically associated with gastroesophageal reflux disease and does not show any abnormal findings on manometry.
Understanding Dysphagia and its Causes
Dysphagia, or difficulty in swallowing, can be caused by various conditions affecting the oesophagus, including cancer, oesophagitis, candidiasis, achalasia, pharyngeal pouch, systemic sclerosis, myasthenia gravis, and globus hystericus. These conditions have distinct features that can help in their diagnosis, such as weight loss and anorexia in oesophageal cancer, heartburn in oesophagitis, dysphagia of both liquids and solids in achalasia, and anxiety in globus hystericus. Dysphagia can also be classified as extrinsic, intrinsic, or neurological, depending on the underlying cause.
To diagnose dysphagia, patients usually undergo an upper GI endoscopy, a full blood count, and fluoroscopic swallowing studies. Additional tests, such as ambulatory oesophageal pH and manometry studies, may be needed for specific conditions. It’s important to note that new-onset dysphagia is a red flag symptom that requires urgent endoscopy, regardless of age or other symptoms. By understanding the causes and features of dysphagia, healthcare professionals can provide timely and appropriate management for their patients.
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This question is part of the following fields:
- Gastrointestinal System
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Question 10
Correct
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Which of the following suppresses the production of stomach acid?
Your Answer: Nausea
Explanation:Gastric secretion is suppressed by nausea through the involvement of higher cerebral activity and sympathetic innervation.
Understanding Gastric Secretions for Surgical Procedures
A basic understanding of gastric secretions is crucial for surgeons, especially when dealing with patients who have undergone acid-lowering procedures or are prescribed anti-secretory drugs. Gastric acid, produced by the parietal cells in the stomach, has a pH of around 2 and is maintained by the H+/K+ ATPase pump. Sodium and chloride ions are actively secreted from the parietal cell into the canaliculus, creating a negative potential across the membrane. Carbonic anhydrase forms carbonic acid, which dissociates, and the hydrogen ions formed by dissociation leave the cell via the H+/K+ antiporter pump. This leaves hydrogen and chloride ions in the canaliculus, which mix and are secreted into the lumen of the oxyntic gland.
There are three phases of gastric secretion: the cephalic phase, gastric phase, and intestinal phase. The cephalic phase is stimulated by the smell or taste of food and causes 30% of acid production. The gastric phase, which is caused by stomach distension, low H+, or peptides, causes 60% of acid production. The intestinal phase, which is caused by high acidity, distension, or hypertonic solutions in the duodenum, inhibits gastric acid secretion via enterogastrones and neural reflexes.
The regulation of gastric acid production involves various factors that increase or decrease production. Factors that increase production include vagal nerve stimulation, gastrin release, and histamine release. Factors that decrease production include somatostatin, cholecystokinin, and secretin. Understanding these factors and their associated pharmacology is essential for surgeons.
In summary, a working knowledge of gastric secretions is crucial for surgical procedures, especially when dealing with patients who have undergone acid-lowering procedures or are prescribed anti-secretory drugs. Understanding the phases of gastric secretion and the regulation of gastric acid production is essential for successful surgical outcomes.
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This question is part of the following fields:
- Gastrointestinal System
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Question 11
Correct
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A 32-year-old female with a history of iron deficiency anemia presents to the hospital with pain in the right upper quadrant. After diagnosis, she is found to have acute cholecystitis. Which of the following is NOT a risk factor for the development of gallstones?
Your Answer: Iron deficiency anaemia
Explanation:The following factors increase the likelihood of developing gallstones and can be remembered as the ‘5 F’s’:
– Being overweight (having a body mass index greater than 30 kg/m2)
– Being female
– Being of reproductive age
– Being of fair complexion (Caucasian)
– Being 40 years of age or olderGallstones are a common condition, with up to 24% of women and 12% of men affected. Local infection and cholecystitis may develop in up to 30% of cases, and 12% of patients undergoing surgery will have stones in the common bile duct. The majority of gallstones are of mixed composition, with pure cholesterol stones accounting for 20% of cases. Symptoms typically include colicky right upper quadrant pain that worsens after fatty meals. Diagnosis is usually made through abdominal ultrasound and liver function tests, with magnetic resonance cholangiography or intraoperative imaging used to confirm suspected bile duct stones. Treatment options include expectant management for asymptomatic gallstones, laparoscopic cholecystectomy for symptomatic gallstones, and surgical management for stones in the common bile duct. ERCP may be used to remove bile duct stones, but carries risks such as bleeding, duodenal perforation, cholangitis, and pancreatitis.
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This question is part of the following fields:
- Gastrointestinal System
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Question 12
Correct
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On examining the caecum, what structure is most likely to be detected at the point where all the tenia coli converge?
Your Answer: Appendix base
Explanation:The tenia coli come together at the bottom of the appendix.
The Caecum: Location, Relations, and Functions
The caecum is a part of the colon located in the proximal right colon below the ileocaecal valve. It is an intraperitoneal structure that has posterior relations with the psoas, iliacus, femoral nerve, genitofemoral nerve, and gonadal vessels. Its anterior relations include the greater omentum. The caecum is supplied by the ileocolic artery and its lymphatic drainage is through the mesenteric nodes that accompany the venous drainage.
The caecum is known for its distensibility, making it the most distensible part of the colon. However, in cases of complete large bowel obstruction with a competent ileocaecal valve, the caecum is the most likely site of eventual perforation. Despite this potential complication, the caecum plays an important role in the digestive system. It is responsible for the absorption of fluids and electrolytes, as well as the fermentation of indigestible carbohydrates. Additionally, the caecum is a site for the growth and proliferation of beneficial bacteria that aid in digestion and immune function.
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This question is part of the following fields:
- Gastrointestinal System
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Question 13
Correct
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A 61-year-old man is having surgery for a cancerous tumor in the splenic flexure of his colon. During the procedure, the surgeons cut the middle colic vein near its source. What is the primary drainage location for this vessel?
Your Answer: Superior mesenteric vein
Explanation:If the middle colonic vein is torn during mobilization, it can lead to severe bleeding that may be challenging to manage as it drains into the SMV.
The Transverse Colon: Anatomy and Relations
The transverse colon is a part of the large intestine that begins at the hepatic flexure, where the right colon makes a sharp turn. At this point, it becomes intraperitoneal and is connected to the inferior border of the pancreas by the transverse mesocolon. The middle colic artery and vein are contained within the mesentery. The greater omentum is attached to the superior aspect of the transverse colon, which can be easily separated. The colon undergoes another sharp turn at the splenic flexure, where the greater omentum remains attached up to this point. The distal 1/3 of the transverse colon is supplied by the inferior mesenteric artery.
The transverse colon is related to various structures. Superiorly, it is in contact with the liver, gallbladder, the greater curvature of the stomach, and the lower end of the spleen. Inferiorly, it is related to the small intestine. Anteriorly, it is in contact with the greater omentum, while posteriorly, it is in contact with the descending portion of the duodenum, the head of the pancreas, convolutions of the jejunum and ileum, and the spleen. Understanding the anatomy and relations of the transverse colon is important for medical professionals in diagnosing and treating various gastrointestinal conditions.
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This question is part of the following fields:
- Gastrointestinal System
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Question 14
Correct
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An 80-year-old male with Parkinson's disease (PD) arrives at the emergency department with sudden chest pain, indicating a possible heart attack. What treatment should be avoided in the management of this patient?
Your Answer: Metoclopramide
Explanation:Metoclopramide should not be given to patients with Parkinsonism due to its dopamine antagonist properties which can worsen the symptoms of the disease. However, it can be prescribed as an antiemetic when administering morphine to ACS patients who are not contraindicated. Oxygen is safe for PD patients, while clopidogrel is used for its antiplatelet effects.
Understanding the Mechanism and Uses of Metoclopramide
Metoclopramide is a medication primarily used to manage nausea, but it also has other uses such as treating gastro-oesophageal reflux disease and gastroparesis secondary to diabetic neuropathy. It is often combined with analgesics for the treatment of migraines. However, it is important to note that metoclopramide has adverse effects such as extrapyramidal effects, acute dystonia, diarrhoea, hyperprolactinaemia, tardive dyskinesia, and parkinsonism. It should also be avoided in bowel obstruction but may be helpful in paralytic ileus.
The mechanism of action of metoclopramide is quite complicated. It is primarily a D2 receptor antagonist, but it also has mixed 5-HT3 receptor antagonist/5-HT4 receptor agonist activity. Its antiemetic action is due to its antagonist activity at D2 receptors in the chemoreceptor trigger zone, and at higher doses, the 5-HT3 receptor antagonist also has an effect. The gastroprokinetic activity is mediated by D2 receptor antagonist activity and 5-HT4 receptor agonist activity.
In summary, metoclopramide is a medication with multiple uses, but it also has adverse effects that should be considered. Its mechanism of action is complex, involving both D2 receptor antagonist and 5-HT3 receptor antagonist/5-HT4 receptor agonist activity. Understanding the uses and mechanism of action of metoclopramide is important for its safe and effective use.
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This question is part of the following fields:
- Gastrointestinal System
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Question 15
Incorrect
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An 83-year-old woman comes to your clinic with a painful red swelling on her cheek that she noticed this morning. She has been feeling fatigued for a few days. The patient lives alone and has a history of pressure ulcers due to limited mobility. During the examination, you observe an erythematous swelling above the right angle of the mandible that is warm and tender to the touch. You suspect that the patient has a parotid gland infection. What is the nerve that provides sensation to the parotid gland capsule?
Your Answer: Glossopharyngeal nerve
Correct Answer: Greater auricular nerve
Explanation:The greater auricular nerve (GAN) supplies sensation to the parotid gland, skin overlying the gland, mastoid process, and outer ear. The facial nerve supplies muscles of facial expression, taste from the anterior two-thirds of the tongue, and sensation from parts of the external acoustic meatus, auricle, and retro-auricular area. The mandibular nerve carries sensory and motor fibers, supplying sensation to the lower lip, lower teeth and gingivae, chin, and jaw, and motor innervation to muscles of mastication. The lingual nerve supplies sensation to the tongue and travels with taste fibers from the chorda tympani of the facial nerve. The glossopharyngeal nerve carries taste and sensation from the posterior third of the tongue, sensation from the pharyngeal wall and tonsils, the middle ear, external auditory canal, and auricle, and parasympathetic fibers that supply the parotid gland. Infective parotitis is uncommon and has increased risk in dehydrated or intubated elderly patients.
The parotid gland is located in front of and below the ear, overlying the mandibular ramus. Its salivary duct crosses the masseter muscle, pierces the buccinator muscle, and drains adjacent to the second upper molar tooth. The gland is traversed by several structures, including the facial nerve, external carotid artery, retromandibular vein, and auriculotemporal nerve. The gland is related to the masseter muscle, medial pterygoid muscle, superficial temporal and maxillary artery, facial nerve, stylomandibular ligament, posterior belly of the digastric muscle, sternocleidomastoid muscle, stylohyoid muscle, internal carotid artery, mastoid process, and styloid process. The gland is supplied by branches of the external carotid artery and drained by the retromandibular vein. Its lymphatic drainage is to the deep cervical nodes. The gland is innervated by the parasympathetic-secretomotor, sympathetic-superior cervical ganglion, and sensory-greater auricular nerve. Parasympathetic stimulation produces a water-rich, serous saliva, while sympathetic stimulation leads to the production of a low volume, enzyme-rich saliva.
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This question is part of the following fields:
- Gastrointestinal System
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Question 16
Correct
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In individuals with an annular pancreas, what is the most probable location of blockage?
Your Answer: The second part of the duodenum
Explanation:The pancreas is formed from two outgrowths of the foregut, namely the ventral and dorsal buds. As the rotation process takes place, the ventral bud merges with the gallbladder and bile duct, which are located nearby. However, if the pancreas fails to rotate properly, it may exert pressure on the duodenum, leading to obstruction. This condition is often caused by an abnormality in the development of the duodenum, and the most commonly affected area is the second part of the duodenum.
Anatomy of the Pancreas
The pancreas is located behind the stomach and is a retroperitoneal organ. It can be accessed surgically by dividing the peritoneal reflection that connects the greater omentum to the transverse colon. The pancreatic head is situated in the curvature of the duodenum, while its tail is close to the hilum of the spleen. The pancreas has various relations with other organs, such as the inferior vena cava, common bile duct, renal veins, superior mesenteric vein and artery, crus of diaphragm, psoas muscle, adrenal gland, kidney, aorta, pylorus, gastroduodenal artery, and splenic hilum.
The arterial supply of the pancreas is through the pancreaticoduodenal artery for the head and the splenic artery for the rest of the organ. The venous drainage for the head is through the superior mesenteric vein, while the body and tail are drained by the splenic vein. The ampulla of Vater is an important landmark that marks the transition from foregut to midgut and is located halfway along the second part of the duodenum. Overall, understanding the anatomy of the pancreas is crucial for surgical procedures and diagnosing pancreatic diseases.
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This question is part of the following fields:
- Gastrointestinal System
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Question 17
Correct
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Throughout the process of embryonic development, what is the accurate source of the pancreas?
Your Answer: Ventral and dorsal endodermal outgrowths of the duodenum
Explanation:The pancreas originates from two outgrowths of the duodenum – one from the ventral side and the other from the dorsal side. The ventral outgrowth is located near or together with the hepatic diverticulum, while the larger dorsal outgrowth emerges slightly above the ventral one and extends into the mesoduodenum and mesogastrium. After the two buds merge, the duct of the ventral outgrowth becomes the primary pancreatic duct.
Anatomy of the Pancreas
The pancreas is located behind the stomach and is a retroperitoneal organ. It can be accessed surgically by dividing the peritoneal reflection that connects the greater omentum to the transverse colon. The pancreatic head is situated in the curvature of the duodenum, while its tail is close to the hilum of the spleen. The pancreas has various relations with other organs, such as the inferior vena cava, common bile duct, renal veins, superior mesenteric vein and artery, crus of diaphragm, psoas muscle, adrenal gland, kidney, aorta, pylorus, gastroduodenal artery, and splenic hilum.
The arterial supply of the pancreas is through the pancreaticoduodenal artery for the head and the splenic artery for the rest of the organ. The venous drainage for the head is through the superior mesenteric vein, while the body and tail are drained by the splenic vein. The ampulla of Vater is an important landmark that marks the transition from foregut to midgut and is located halfway along the second part of the duodenum. Overall, understanding the anatomy of the pancreas is crucial for surgical procedures and diagnosing pancreatic diseases.
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This question is part of the following fields:
- Gastrointestinal System
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Question 18
Correct
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A 35-year-old female patient visits the gastroenterology clinic complaining of abdominal discomfort, bloating, flatulence, and diarrhea that have persisted for 8 months. She reports that her symptoms worsen after consuming meals, particularly those high in carbohydrates. During the examination, the gastroenterologist observes no significant abdominal findings but notices rashes on her elbows and knees. As part of her diagnostic workup, the gastroenterologist is contemplating endoscopy and small bowel biopsy. What is the probable biopsy result?
Your Answer: Villous atrophy
Explanation:Coeliac disease can be diagnosed through a biopsy that shows villous atrophy, raised intra-epithelial lymphocytes, and crypt hyperplasia. This condition is likely the cause of the patient’s chronic symptoms, which are triggered by meals containing gluten. Fortunately, adhering to a strict gluten-free diet can reverse the villous atrophy. In some cases, coeliac disease may also present with a vesicular rash called dermatitis herpetiformis. Other pathological findings, such as mucosal defects, irregular gland-like structures, or transmural inflammation with granulomas and lymphoid aggregates, suggest different diseases.
Investigating Coeliac Disease
Coeliac disease is a condition caused by sensitivity to gluten, which leads to villous atrophy and malabsorption. It is often associated with other conditions such as dermatitis herpetiformis and autoimmune disorders. Diagnosis is made through a combination of serology and endoscopic intestinal biopsy, with villous atrophy and immunology typically reversing on a gluten-free diet.
To investigate coeliac disease, NICE guidelines recommend using tissue transglutaminase (TTG) antibodies (IgA) as the first-choice serology test, along with endomyseal antibody (IgA) and testing for selective IgA deficiency. Anti-gliadin antibody (IgA or IgG) tests are not recommended. The ‘gold standard’ for diagnosis is an endoscopic intestinal biopsy, which should be performed in all suspected cases to confirm or exclude the diagnosis. Findings supportive of coeliac disease include villous atrophy, crypt hyperplasia, increase in intraepithelial lymphocytes, and lamina propria infiltration with lymphocytes. Rectal gluten challenge is a less commonly used method.
In summary, investigating coeliac disease involves a combination of serology and endoscopic intestinal biopsy, with NICE guidelines recommending specific tests and the ‘gold standard’ being an intestinal biopsy. Findings supportive of coeliac disease include villous atrophy, crypt hyperplasia, and lymphocyte infiltration.
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This question is part of the following fields:
- Gastrointestinal System
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Question 19
Correct
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A 25-year-old male presents to the emergency department with upper abdominal pain that radiates to the back. This started a few hours previously and has been accompanied by some nausea and vomiting. The patient denies any alcohol intake recently.
On examination, he has tenderness in the epigastric and right upper quadrant regions. He has a fever of 38.9°C. An ultrasound scan reveals no evidence of gallstones. The patient is given a preliminary diagnosis of acute pancreatitis and some blood tests are requested.
What could be the cause of this patient's condition?Your Answer: Mumps
Explanation:Mumps is a known cause of acute pancreatitis, but it has become rare since the introduction of the MMR vaccine. In 2018, there were only 1088 cases of mumps in the UK, which statistically translates to around 54 cases of acute pancreatitis secondary to mumps. Inflammatory bowel disease may also lead to pancreatitis, but it is usually caused by gallstones or medication used to treat IBD. While influenzae and gastroenteritis are not commonly associated with pancreatitis, there have been a few reported cases linking influenzae A to acute pancreatitis, although these occurrences are extremely rare.
Acute pancreatitis is a condition that is primarily caused by gallstones and alcohol consumption in the UK. However, there are other factors that can contribute to the development of this condition. A popular mnemonic used to remember these factors is GET SMASHED, which stands for gallstones, ethanol, trauma, steroids, mumps, autoimmune diseases, scorpion venom, hypertriglyceridaemia, hyperchylomicronaemia, hypercalcaemia, hypothermia, ERCP, and certain drugs. It is important to note that pancreatitis is seven times more common in patients taking mesalazine than sulfasalazine. CT scans can show diffuse parenchymal enlargement with oedema and indistinct margins in patients with acute pancreatitis.
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This question is part of the following fields:
- Gastrointestinal System
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Question 20
Correct
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A 72-year-old man complains of abdominal pain indicative of mesenteric ischaemia and is rushed to the operating room for an urgent laparotomy. During the procedure, it is discovered that the affected portion of the bowel extends from the splenic flexure of the colon to the rectum. Can you determine the vertebral level at which the obstructed artery branches off from the aorta?
Your Answer: L3
Explanation:The hindgut, which is a segment of the gut, receives its blood supply from the inferior mesenteric artery. This artery originates from the aorta at the L3 vertebrae.
The Inferior Mesenteric Artery: Supplying the Hindgut
The inferior mesenteric artery (IMA) is responsible for supplying the embryonic hindgut with blood. It originates just above the aortic bifurcation, at the level of L3, and passes across the front of the aorta before settling on its left side. At the point where the left common iliac artery is located, the IMA becomes the superior rectal artery.
The hindgut, which includes the distal third of the colon and the rectum above the pectinate line, is supplied by the IMA. The left colic artery is one of the branches that emerges from the IMA near its origin. Up to three sigmoid arteries may also exit the IMA to supply the sigmoid colon further down the line.
Overall, the IMA plays a crucial role in ensuring that the hindgut receives the blood supply it needs to function properly. Its branches help to ensure that the colon and rectum are well-nourished and able to carry out their important digestive functions.
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This question is part of the following fields:
- Gastrointestinal System
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Question 21
Correct
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A surgeon is scheduled to perform a laparotomy for a perforated duodenal ulcer on a pediatric patient. An upper midline incision will be made. Which structure is most likely to be divided by the incision?
Your Answer: Linea alba
Explanation:When performing upper midline abdominal incisions, the linea alba is typically divided. It is not common to divide muscles in this approach, as it does not typically enhance access and encountering them is not a routine occurrence.
Abdominal Incisions: Types and Techniques
Abdominal incisions are surgical procedures that involve making an opening in the abdominal wall to access the organs inside. The most common approach is the midline incision, which involves dividing the linea alba, transversalis fascia, extraperitoneal fat, and peritoneum. Another type is the paramedian incision, which is parallel to the midline and involves dividing the anterior rectus sheath, rectus, posterior rectus sheath, transversalis fascia, extraperitoneal fat, and peritoneum. The battle incision is similar to the paramedian but involves displacing the rectus medially.
Other types of abdominal incisions include Kocher’s incision under the right subcostal margin for cholecystectomy, Lanz incision in the right iliac fossa for appendicectomy, gridiron oblique incision centered over McBurney’s point for appendicectomy, Pfannenstiel’s transverse supra-pubic incision primarily used to access pelvic organs, McEvedy’s groin incision for emergency repair of a strangulated femoral hernia, and Rutherford Morrison extraperitoneal approach to the left or right lower quadrants for access to iliac vessels and renal transplantation.
Each type of incision has its own advantages and disadvantages, and the choice of incision depends on the specific surgical procedure and the surgeon’s preference. Proper closure of the incision is crucial to prevent complications such as infection and hernia formation. Overall, abdominal incisions are important techniques in surgical practice that allow for safe and effective access to the abdominal organs.
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This question is part of the following fields:
- Gastrointestinal System
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Question 22
Correct
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A 67-year-old man comes to the emergency department complaining of abrupt abdominal pain. He reports the pain as cramping, with a severity of 6/10, and spread throughout his abdomen. The patient has a medical history of hypertension and type 2 diabetes mellitus. He used to smoke and has a smoking history of 40 pack years.
What is the most probable part of the colon affected in this patient?Your Answer: Splenic flexure
Explanation:Ischaemic colitis frequently affects the splenic flexure, which is a vulnerable area due to its location at the border of regions supplied by different arteries. Symptoms such as cramping and generalised abdominal pain, along with a history of smoking and hypertension, suggest a diagnosis of ischaemic colitis. While the rectosigmoid junction is also a watershed area, it is less commonly affected than the splenic flexure. Other regions of the large bowel are less susceptible to ischaemic colitis.
Understanding Ischaemic Colitis
Ischaemic colitis is a condition that occurs when there is a temporary reduction in blood flow to the large bowel. This can cause inflammation, ulcers, and bleeding. The condition is more likely to occur in areas of the bowel that are located at the borders of the territory supplied by the superior and inferior mesenteric arteries, such as the splenic flexure.
When investigating ischaemic colitis, doctors may look for a sign called thumbprinting on an abdominal x-ray. This occurs due to mucosal edema and hemorrhage. It is important to diagnose and treat ischaemic colitis promptly to prevent complications and ensure a full recovery.
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This question is part of the following fields:
- Gastrointestinal System
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Question 23
Correct
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A 35-year-old woman has been diagnosed with gonorrhoeae and prescribed ceftriaxone. She later presents at the emergency department with severe abdominal pain, elevated white blood cell count, and signs of severe colitis. What is the most probable causative organism for these symptoms?
Your Answer: Clostridium difficile
Explanation:The correct answer is C. difficile, as it is the causative organism in pseudomembranous colitis that can occur after recent use of broad-spectrum antibiotics like ceftriaxone. These antibiotics can disrupt the gut flora, allowing C. difficile to thrive. Other antibiotics that can cause C. difficile include PPI, clindamycin, and fluoroquinolones.
Campylobacter, Escherichia coli, and Neisseria gonorrhoeae are incorrect answers. Campylobacter infections are typically caused by undercooked chicken, untreated water, or international travel. E. coli infections are usually caused by contact with infected feces, unwashed foods, or unclean water. Neisseria gonorrhoeae is a sexually transmitted disease that is spread through unprotected sex, not through recent use of broad-spectrum antibiotics. The patient in this case does not have symptoms of gonorrhoeae and there is no indication of unprotected sex after the antibiotic prescription.
Clostridium difficile is a type of bacteria that is commonly found in hospitals. It produces a toxin that can damage the intestines and cause a condition called pseudomembranous colitis. This bacteria usually develops when the normal gut flora is disrupted by broad-spectrum antibiotics, with second and third generation cephalosporins being the leading cause. Other risk factors include the use of proton pump inhibitors. Symptoms of C. difficile infection include diarrhea, abdominal pain, and a raised white blood cell count. The severity of the infection can be determined using the Public Health England severity scale.
To diagnose C. difficile infection, a stool sample is tested for the presence of the C. difficile toxin. Treatment involves reviewing current antibiotic therapy and stopping antibiotics if possible. For a first episode of infection, oral vancomycin is the first-line therapy for 10 days, followed by oral fidaxomicin as second-line therapy and oral vancomycin with or without IV metronidazole as third-line therapy. Recurrent infections may require different treatment options, such as oral fidaxomicin within 12 weeks of symptom resolution or oral vancomycin or fidaxomicin after 12 weeks of symptom resolution. In life-threatening cases, oral vancomycin and IV metronidazole may be used, and surgery may be considered with specialist advice. Other therapies, such as bezlotoxumab and fecal microbiota transplant, may also be considered for preventing recurrences in certain cases.
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This question is part of the following fields:
- Gastrointestinal System
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Question 24
Correct
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Sophie, a 19-year-old girl with type 1 diabetes mellitus, arrives at the emergency department with confusion, vomiting, and abdominal pain. Upon examination, she displays tachycardia and tachypnea. The medical team orders various tests, including an arterial blood gas.
The results are as follows:
pH 7.29 mmol/l
K+ 6.0 mmol/l
Glucose 15mmol/l
The doctors initiate treatment for diabetic ketoacidosis.
What ECG abnormality can be observed in relation to Sophie's potassium level?Your Answer: Tall tented T waves and flattened P waves
Explanation:When a person has hyperkalaemia, their blood has an excess of potassium which can lead to cardiac arrhythmias. One of the common ECG abnormalities seen in hyperkalaemia is tall tented T waves. Other possible ECG changes include wide QRS complexes and flattened P waves. In contrast, hypokalaemia can cause T wave depression, U waves, and tall P waves on an ECG. Delta waves are typically seen in patients with Wolfe-Parkinson-White syndrome.
ECG Findings in Hyperkalaemia
Hyperkalaemia is a condition characterized by high levels of potassium in the blood. This condition can have serious consequences on the heart, leading to abnormal ECG findings. The ECG findings in hyperkalaemia include peaked or ‘tall-tented’ T waves, loss of P waves, broad QRS complexes, sinusoidal wave pattern, and ventricular fibrillation.
The first ECG finding in hyperkalaemia is the appearance of peaked or ‘tall-tented’ T waves. This is followed by the loss of P waves, which are the small waves that represent atrial depolarization. The QRS complexes, which represent ventricular depolarization, become broad and prolonged. The sinusoidal wave pattern is a characteristic finding in severe hyperkalaemia, where the ECG tracing appears as a series of undulating waves. Finally, ventricular fibrillation, a life-threatening arrhythmia, can occur in severe hyperkalaemia.
In summary, hyperkalaemia can have serious consequences on the heart, leading to abnormal ECG findings. These findings include peaked or ‘tall-tented’ T waves, loss of P waves, broad QRS complexes, sinusoidal wave pattern, and ventricular fibrillation. It is important to recognize these ECG findings in hyperkalaemia as they can guide appropriate management and prevent life-threatening complications.
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This question is part of the following fields:
- Gastrointestinal System
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Question 25
Incorrect
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A 28-year-old male patient is diagnosed with an inguinal hernia and is scheduled for open surgical repair. During the procedure, the surgeons opt to use a mesh to reinforce the posterior wall of the inguinal canal. What structures will be located behind the mesh?
Your Answer: Rectus abdominis
Correct Answer: Transversalis fascia
Explanation:The posterior wall of the inguinal canal is formed by the transversalis fascia, the conjoint tendon, and the deep inguinal ring located laterally. The superior wall (roof) is made up of the internal oblique and transversus abdominis muscles, while the anterior wall consists of the aponeurosis of the external oblique and internal oblique muscles. The lower wall (floor) is formed by the inguinal ligament and lacunar ligament.
The inguinal canal is located above the inguinal ligament and measures 4 cm in length. Its superficial ring is situated in front of the pubic tubercle, while the deep ring is found about 1.5-2 cm above the halfway point between the anterior superior iliac spine and the pubic tubercle. The canal is bounded by the external oblique aponeurosis, inguinal ligament, lacunar ligament, internal oblique, transversus abdominis, external ring, and conjoint tendon. In males, the canal contains the spermatic cord and ilioinguinal nerve, while in females, it houses the round ligament of the uterus and ilioinguinal nerve.
The boundaries of Hesselbach’s triangle, which are frequently tested, are located in the inguinal region. Additionally, the inguinal canal is closely related to the vessels of the lower limb, which should be taken into account when repairing hernial defects in this area.
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This question is part of the following fields:
- Gastrointestinal System
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Question 26
Correct
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A 75-year-old man presents with a sizable abdominal aortic aneurysm. While undergoing a laparotomy for scheduled surgical intervention, the medical team discovers that the aneurysm is situated much closer to the origin of the SMA. While dissecting the area, a transverse vessel running across the aorta sustains damage. What is the most probable identity of this vessel?
Your Answer: Left renal vein
Explanation:During the repair of a juxtarenal aneurysm, intentional ligation of the left renal vein may be necessary as it travels over the aorta.
The abdominal aorta is a major blood vessel that originates from the 12th thoracic vertebrae and terminates at the fourth lumbar vertebrae. It is located in the abdomen and is surrounded by various organs and structures. The posterior relations of the abdominal aorta include the vertebral bodies of the first to fourth lumbar vertebrae. The anterior relations include the lesser omentum, liver, left renal vein, inferior mesenteric vein, third part of the duodenum, pancreas, parietal peritoneum, and peritoneal cavity. The right lateral relations include the right crus of the diaphragm, cisterna chyli, azygos vein, and inferior vena cava (which becomes posterior distally). The left lateral relations include the fourth part of the duodenum, duodenal-jejunal flexure, and left sympathetic trunk. Overall, the abdominal aorta is an important blood vessel that supplies oxygenated blood to various organs in the abdomen.
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This question is part of the following fields:
- Gastrointestinal System
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Question 27
Correct
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A 25-year-old man is suspected of having an inflamed Meckel's diverticulum. Where is it most likely to be located?
Your Answer: Approximately 60 cm proximal to the ileocaecal valve
Explanation:The length of these growths is 2 inches (5cm), and they are twice as common in men. They involve two types of tissue and are located approximately 2 feet (60cm) from the ileocaecal valve.
Meckel’s diverticulum is a congenital diverticulum of the small intestine that is a remnant of the omphalomesenteric duct. It occurs in 2% of the population, is 2 feet from the ileocaecal valve, and is 2 inches long. It is usually asymptomatic but can present with abdominal pain, rectal bleeding, or intestinal obstruction. Investigation includes a Meckel’s scan or mesenteric arteriography. Management involves removal if narrow neck or symptomatic, with options between wedge excision or formal small bowel resection and anastomosis. Meckel’s diverticulum is typically lined by ileal mucosa but ectopic gastric, pancreatic, and jejunal mucosa can also occur.
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This question is part of the following fields:
- Gastrointestinal System
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Question 28
Correct
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A 29-year-old woman reports experiencing watery stools and fecal urgency after undergoing gastrointestinal surgery to treat chronic bowel inflammation. While she suspects she may have developed irritable bowel syndrome, further investigation suggests that she may be suffering from bile acid malabsorption as a result of her surgery.
Where is the most likely site of this patient's surgery?Your Answer: Terminal ileum
Explanation:The primary role of the large intestine is to absorb water and create solid waste.
Bile is a liquid that is produced in the liver at a rate of 500ml to 1500mL per day. It is made up of bile salts, bicarbonate, cholesterol, steroids, and water. The flow of bile is regulated by three factors: hepatic secretion, gallbladder contraction, and sphincter of oddi resistance. Bile salts are absorbed in the terminal ileum and are recycled up to six times a day, with over 90% of all bile salts being recycled.
There are two types of bile salts: primary and secondary. Primary bile salts include cholate and chenodeoxycholate, while secondary bile salts are formed by bacterial action on primary bile salts and include deoxycholate and lithocholate. Deoxycholate is reabsorbed, while lithocholate is insoluble and excreted.
Gallstones can form when there is an excess of cholesterol in the bile. Bile salts have a detergent action and form micelles, which have a lipid center that transports fats. However, excessive amounts of cholesterol cannot be transported in this way and will precipitate, resulting in the formation of cholesterol-rich gallstones.
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This question is part of the following fields:
- Gastrointestinal System
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Question 29
Incorrect
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A 72-year-old man is receiving an angiogram to investigate gastrointestinal bleeding. During the procedure, the radiologist inserts the catheter into the coeliac axis. What is the usual spinal level where this vessel originates from the aorta?
Your Answer: T10
Correct Answer: T12
Explanation:The coeliac axis is positioned at T12 and branches off the aorta at an almost horizontal angle. It comprises three significant branches.
Branches of the Abdominal Aorta
The abdominal aorta is a major blood vessel that supplies oxygenated blood to the abdominal organs and lower extremities. It gives rise to several branches that supply blood to various organs and tissues. These branches can be classified into two types: parietal and visceral.
The parietal branches supply blood to the walls of the abdominal cavity, while the visceral branches supply blood to the abdominal organs. The branches of the abdominal aorta include the inferior phrenic, coeliac, superior mesenteric, middle suprarenal, renal, gonadal, lumbar, inferior mesenteric, median sacral, and common iliac arteries.
The inferior phrenic artery arises from the upper border of the abdominal aorta and supplies blood to the diaphragm. The coeliac artery supplies blood to the liver, stomach, spleen, and pancreas. The superior mesenteric artery supplies blood to the small intestine, cecum, and ascending colon. The middle suprarenal artery supplies blood to the adrenal gland. The renal arteries supply blood to the kidneys. The gonadal arteries supply blood to the testes or ovaries. The lumbar arteries supply blood to the muscles and skin of the back. The inferior mesenteric artery supplies blood to the descending colon, sigmoid colon, and rectum. The median sacral artery supplies blood to the sacrum and coccyx. The common iliac arteries are the terminal branches of the abdominal aorta and supply blood to the pelvis and lower extremities.
Understanding the branches of the abdominal aorta is important for diagnosing and treating various medical conditions that affect the abdominal organs and lower extremities.
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This question is part of the following fields:
- Gastrointestinal System
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Question 30
Correct
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A 32-year-old woman undergoes a colonoscopy and a biopsy reveals a malignant tumour in her sigmoid colon. Her grandmother died of colorectal cancer at 30-years-old and her father developed endometrial cancer at 40-years-old. Which gene is suspected to be responsible for this condition?
Your Answer: Mismatch repair genes
Explanation:The patient’s familial background indicates the possibility of Lynch syndrome, given that several of his close relatives developed cancer at a young age. This is supported by the fact that his family has a history of both colorectal cancer, which may indicate a defect in the APC gene, and endometrial cancer, which is also linked to Lynch syndrome. Lynch syndrome is associated with mutations in mismatch repair genes such as MSH2, MLH1, PMS2, and GTBP, which are responsible for identifying and repairing errors that occur during DNA replication, such as insertions and deletions of bases. Mutations in these genes can increase the risk of developing cancers such as colorectal, endometrial, and renal cancer.
Colorectal cancer can be classified into three types: sporadic, hereditary non-polyposis colorectal carcinoma (HNPCC), and familial adenomatous polyposis (FAP). Sporadic colon cancer is believed to be caused by a series of genetic mutations, including allelic loss of the APC gene, activation of the K-ras oncogene, and deletion of p53 and DCC tumor suppressor genes. HNPCC, which is an autosomal dominant condition, is the most common form of inherited colon cancer. It is caused by mutations in genes involved in DNA mismatch repair, leading to microsatellite instability. The most common genes affected are MSH2 and MLH1. Patients with HNPCC are also at a higher risk of other cancers, such as endometrial cancer. The Amsterdam criteria are sometimes used to aid diagnosis of HNPCC. FAP is a rare autosomal dominant condition that leads to the formation of hundreds of polyps by the age of 30-40 years. It is caused by a mutation in the APC gene. Patients with FAP are also at risk of duodenal tumors. A variant of FAP called Gardner’s syndrome can also feature osteomas of the skull and mandible, retinal pigmentation, thyroid carcinoma, and epidermoid cysts on the skin. Genetic testing can be done to diagnose HNPCC and FAP, and patients with FAP generally have a total colectomy with ileo-anal pouch formation in their twenties.
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This question is part of the following fields:
- Gastrointestinal System
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Question 31
Incorrect
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A 58-year-old woman diagnosed with squamous cell carcinoma of the anus is preparing for an abdominoperineal resection (APR). This surgical procedure involves the complete removal of the distal colon, rectum, and anal sphincter complex through both anterior abdominal and perineal incisions, resulting in a permanent colostomy. During the process, several arteries are ligated, including the one that supplies the anal canal below the levator ani. Can you identify the name of this artery and its branching point?
Your Answer: Inferior rectal artery - a branches of deep external pudendal artery
Correct Answer: Inferior rectal artery - a branches of internal pudendal artery
Explanation:The internal pudendal artery gives rise to the inferior rectal artery, which supplies the muscle and skin of the anal and urogenital triangle. The superior rectal artery, on the other hand, supplies the sigmoid mesocolon and not the lower part of the anal canal. The middle rectal artery is a branch of the internal pudendal artery and not the deep external pudendal artery, making the fifth option incorrect.
Anatomy of the Rectum
The rectum is a capacitance organ that measures approximately 12 cm in length. It consists of both intra and extraperitoneal components, with the transition from the sigmoid colon marked by the disappearance of the tenia coli. The extra peritoneal rectum is surrounded by mesorectal fat that contains lymph nodes, which are removed during rectal cancer surgery. The fascial layers that surround the rectum are important clinical landmarks, with the fascia of Denonvilliers located anteriorly and Waldeyers fascia located posteriorly.
In males, the rectum is adjacent to the rectovesical pouch, bladder, prostate, and seminal vesicles, while in females, it is adjacent to the recto-uterine pouch (Douglas), cervix, and vaginal wall. Posteriorly, the rectum is in contact with the sacrum, coccyx, and middle sacral artery, while laterally, it is adjacent to the levator ani and coccygeus muscles.
The superior rectal artery supplies blood to the rectum, while the superior rectal vein drains it. Mesorectal lymph nodes located superior to the dentate line drain into the internal iliac and then para-aortic nodes, while those located inferior to the dentate line drain into the inguinal nodes. Understanding the anatomy of the rectum is crucial for surgical procedures and the diagnosis and treatment of rectal diseases.
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This question is part of the following fields:
- Gastrointestinal System
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Question 32
Incorrect
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A 56-year-old woman arrives at the emergency department complaining of abdominal pain that has been ongoing for two days. The pain is diffuse, sudden in onset, and not radiating. She has a medical history of antiphospholipid syndrome but no cirrhosis.
Upon examination, the patient is visibly jaundiced and her abdomen is noticeably distended. There is painful hepatomegaly and shifting dullness. Abdominal ultrasonography confirms the presence of ascites and venous outflow obstruction.
Which vessel is the most likely culprit for the occlusion?Your Answer: Hepatic portal vein
Correct Answer: Hepatic vein
Explanation:Budd-Chiari syndrome is caused by thrombosis of the hepatic vein, resulting in symptoms such as painful hepatomegaly, jaundice, and ascites. This patient’s antiphospholipid syndrome increases their risk of thrombosis, making Budd-Chiari syndrome more likely than hepatic portal vein thrombosis. Inferior mesenteric vein thrombosis is an unlikely cause of the patient’s symptoms, while inferior vena cava thrombosis would present differently and is associated with lung malignancy.
Understanding Budd-Chiari Syndrome
Budd-Chiari syndrome, also known as hepatic vein thrombosis, is a condition that is often associated with an underlying hematological disease or another procoagulant condition. The causes of this syndrome include polycythemia rubra vera, thrombophilia, pregnancy, and the use of combined oral contraceptive pills. The symptoms of Budd-Chiari syndrome typically include sudden onset and severe abdominal pain, ascites leading to abdominal distension, and tender hepatomegaly.
To diagnose Budd-Chiari syndrome, an ultrasound with Doppler flow studies is usually the initial radiological investigation. This test is highly sensitive and can help identify the presence of the condition. It is important to diagnose and treat Budd-Chiari syndrome promptly to prevent complications such as liver failure and portal hypertension.
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This question is part of the following fields:
- Gastrointestinal System
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Question 33
Correct
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Which layer lies above the outer muscular layer of the intrathoracic oesophagus?
Your Answer: Loose connective tissue
Explanation:Sutures do not hold well on the oesophagus due to the absence of a serosal covering. The Auerbach’s and Meissner’s nerve plexuses are situated between the longitudinal and circular muscle layers, as well as submucosally. The Meissner’s nerve plexus is located in the submucosa, which aids in its sensory function.
Anatomy of the Oesophagus
The oesophagus is a muscular tube that is approximately 25 cm long and starts at the C6 vertebrae, pierces the diaphragm at T10, and ends at T11. It is lined with non-keratinized stratified squamous epithelium and has constrictions at various distances from the incisors, including the cricoid cartilage at 15cm, the arch of the aorta at 22.5cm, the left principal bronchus at 27cm, and the diaphragmatic hiatus at 40cm.
The oesophagus is surrounded by various structures, including the trachea to T4, the recurrent laryngeal nerve, the left bronchus and left atrium, and the diaphragm anteriorly. Posteriorly, it is related to the thoracic duct to the left at T5, the hemiazygos to the left at T8, the descending aorta, and the first two intercostal branches of the aorta. The arterial, venous, and lymphatic drainage of the oesophagus varies depending on the location, with the upper third being supplied by the inferior thyroid artery and drained by the deep cervical lymphatics, the mid-third being supplied by aortic branches and drained by azygos branches and mediastinal lymphatics, and the lower third being supplied by the left gastric artery and drained by posterior mediastinal and coeliac veins and gastric lymphatics.
The nerve supply of the oesophagus also varies, with the upper half being supplied by the recurrent laryngeal nerve and the lower half being supplied by the oesophageal plexus of the vagus nerve. The muscularis externa of the oesophagus is composed of both smooth and striated muscle, with the composition varying depending on the location.
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This question is part of the following fields:
- Gastrointestinal System
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Question 34
Correct
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A 49-year-old woman presents to the emergency department with severe abdominal pain that started an hour ago. She reports feeling unwell recently, but this is the first time she has experienced this type of pain, which is mainly located in the right upper quadrant. During the examination, the physician notes hepatomegaly and ascites, and the patient's eyes have a slight yellow tint. An ultrasound scan reveals reduced blood flow in the hepatic veins, and there is no history of recent travel, drug use, or needlestick injury. The patient has not experienced recent weight loss, and her last menstrual period was two weeks ago. She is not taking any regular or over-the-counter medications. What condition could potentially be causing this patient's symptoms?
Your Answer: Protein C deficiency
Explanation:Budd-Chiari syndrome, which is characterized by abdominal pain, ascites, hepatomegaly, and jaundice, can be caused by hypercoagulable states such as protein C and S deficiencies. In this case, the patient’s protein C deficiency increased their risk of developing a thrombus in the hepatic veins, leading to Budd-Chiari syndrome. Other risk factors for thrombus formation include pregnancy and hepatocellular carcinoma. The use of oral contraceptives would also increase the risk of thrombus formation, while warfarin treatment would decrease it. Atrial fibrillation, on the other hand, would predispose a patient to systemic embolism, which can cause ischaemic symptoms in various arterial circulations.
Understanding Budd-Chiari Syndrome
Budd-Chiari syndrome, also known as hepatic vein thrombosis, is a condition that is often associated with an underlying hematological disease or another procoagulant condition. The causes of this syndrome include polycythemia rubra vera, thrombophilia, pregnancy, and the use of combined oral contraceptive pills. The symptoms of Budd-Chiari syndrome typically include sudden onset and severe abdominal pain, ascites leading to abdominal distension, and tender hepatomegaly.
To diagnose Budd-Chiari syndrome, an ultrasound with Doppler flow studies is usually the initial radiological investigation. This test is highly sensitive and can help identify the presence of the condition. It is important to diagnose and treat Budd-Chiari syndrome promptly to prevent complications such as liver failure and portal hypertension.
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This question is part of the following fields:
- Gastrointestinal System
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Question 35
Incorrect
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What is the urinary diagnostic marker for carcinoid syndrome in elderly patients?
Your Answer: Chromogranin A
Correct Answer: 5-Hydroxyindoleacetic acid
Explanation:The measurement of 5-HIAA in urine is a crucial aspect of clinical monitoring.
Carcinoid tumours are a type of cancer that can cause a condition called carcinoid syndrome. This syndrome typically occurs when the cancer has spread to the liver and releases serotonin into the bloodstream. In some cases, it can also occur with lung carcinoid tumours, as the mediators are not cleared by the liver. The earliest symptom of carcinoid syndrome is often flushing, but it can also cause diarrhoea, bronchospasm, hypotension, and right heart valvular stenosis (or left heart involvement in bronchial carcinoid). Additionally, other molecules such as ACTH and GHRH may be secreted, leading to conditions like Cushing’s syndrome. Pellagra, a rare condition caused by a deficiency in niacin, can also develop as the tumour diverts dietary tryptophan to serotonin.
To investigate carcinoid syndrome, doctors may perform a urinary 5-HIAA test or a plasma chromogranin A test. Treatment for the condition typically involves somatostatin analogues like octreotide, which can help manage symptoms like diarrhoea. Cyproheptadine may also be used to alleviate diarrhoea. Overall, early detection and treatment of carcinoid tumours can help prevent the development of carcinoid syndrome and improve outcomes for patients.
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This question is part of the following fields:
- Gastrointestinal System
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Question 36
Correct
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Which of the following is more frequently observed in individuals with Crohn's disease compared to those with ulcerative colitis?
Your Answer: Fat wrapping of the terminal ileum
Explanation:Smoking has been found to exacerbate Crohn’s disease, and it also increases the risk of disease recurrence after resection. Patients with ileal disease, which is the most common site of the disease, often exhibit fat wrapping of the terminal ileum. The mesenteric fat in patients with inflammatory bowel disease (IBD) is typically dense, hard, and prone to significant bleeding during surgery. During endoscopy, the mucosa in Crohn’s disease patients is described as resembling cobblestones, while ulcerative colitis patients often exhibit mucosal islands (pseudopolyps).
Understanding Crohn’s Disease
Crohn’s disease is a type of inflammatory bowel disease that can affect any part of the digestive tract, from the mouth to the anus. The exact cause of Crohn’s disease is unknown, but there is a strong genetic component. Inflammation occurs in all layers of the affected area, which can lead to complications such as strictures, fistulas, and adhesions.
Symptoms of Crohn’s disease typically appear in late adolescence or early adulthood and can include non-specific symptoms such as weight loss and lethargy, as well as more specific symptoms like diarrhea, abdominal pain, and perianal disease. Extra-intestinal features, such as arthritis, erythema nodosum, and osteoporosis, are also common in patients with Crohn’s disease.
To diagnose Crohn’s disease, doctors may look for raised inflammatory markers, increased faecal calprotectin, anemia, and low levels of vitamin B12 and vitamin D. It’s important to note that Crohn’s disease shares some features with ulcerative colitis, another type of inflammatory bowel disease, but there are also important differences between the two conditions. Understanding the symptoms and diagnostic criteria for Crohn’s disease can help patients and healthcare providers manage this chronic condition more effectively.
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This question is part of the following fields:
- Gastrointestinal System
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Question 37
Correct
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A 16-year-old boy presents to the hospital with suspected appendicitis. Upon examination, he exhibits maximum tenderness at McBurney's point. Can you identify the location of McBurney's point?
Your Answer: 2/3rds laterally along the line between the umbilicus and the anterior superior iliac spine
Explanation:To locate McBurney’s point, one should draw an imaginary line from the umbilicus to the anterior superior iliac spine on the right-hand side and then find the point that is 2/3rds of the way along this line. The other choices do not provide the correct location for this anatomical landmark.
Acute appendicitis is a common condition that requires surgery and can occur at any age, but is most prevalent in young people aged 10-20 years. The pathogenesis of acute appendicitis involves lymphoid hyperplasia or a faecolith, which leads to obstruction of the appendiceal lumen. This obstruction causes gut organisms to invade the appendix wall, resulting in oedema, ischaemia, and possibly perforation.
The most common symptom of acute appendicitis is abdominal pain, which is typically peri-umbilical and radiates to the right iliac fossa due to localised peritoneal inflammation. Other symptoms include mild pyrexia, anorexia, and nausea. Examination may reveal generalised or localised peritonism, rebound and percussion tenderness, guarding and rigidity, and classical signs such as Rovsing’s sign and psoas sign.
Diagnosis of acute appendicitis is typically based on raised inflammatory markers and compatible history and examination findings. Imaging may be used in certain cases, such as ultrasound in females where pelvic organ pathology is suspected. Management of acute appendicitis involves appendicectomy, which can be performed via an open or laparoscopic approach. Patients with perforated appendicitis require copious abdominal lavage, while those without peritonitis who have an appendix mass should receive broad-spectrum antibiotics and consideration given to performing an interval appendicectomy. Intravenous antibiotics alone have been trialled as a treatment for appendicitis, but evidence suggests that this is associated with a longer hospital stay and up to 20% of patients go on to have an appendicectomy within 12 months.
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This question is part of the following fields:
- Gastrointestinal System
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Question 38
Correct
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Samantha is a 42-year-old woman with a lengthy history of alcohol misuse. She visits her physician complaining of ongoing abdominal discomfort, steatorrhea, and weight loss. There is no jaundice present. Tests indicate an increased lipase level and a normal amylase level. An ERCP is performed to examine the biliary system and pancreas.
What is the most probable finding in the pancreas during the ERCP?Your Answer: 'Chain of lakes' appearance
Explanation:Chronic pancreatitis can be diagnosed based on several factors, including alcohol abuse, elevated lipase levels, and normal amylase levels. An ERCP can confirm the diagnosis by revealing the characteristic chain of lakes appearance of the dilated and twisted main pancreatic duct. The absence of systemic symptoms makes a pancreatic abscess or necrosis unlikely, while a normal or absent pancreas is highly improbable.
Understanding Chronic Pancreatitis
Chronic pancreatitis is a condition characterized by inflammation that can affect both the exocrine and endocrine functions of the pancreas. While alcohol excess is the leading cause of this condition, up to 20% of cases are unexplained. Other causes include genetic factors such as cystic fibrosis and haemochromatosis, as well as ductal obstruction due to tumors, stones, and structural abnormalities.
Symptoms of chronic pancreatitis include pain that worsens 15 to 30 minutes after a meal, steatorrhoea, and diabetes mellitus. Abdominal x-rays and CT scans are used to detect pancreatic calcification, which is present in around 30% of cases. Functional tests such as faecal elastase may also be used to assess exocrine function if imaging is inconclusive.
Management of chronic pancreatitis involves pancreatic enzyme supplements, analgesia, and antioxidants. While there is limited evidence to support the use of antioxidants, one study suggests that they may be beneficial in early stages of the disease. Overall, understanding the causes and symptoms of chronic pancreatitis is crucial for effective management and treatment.
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This question is part of the following fields:
- Gastrointestinal System
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Question 39
Correct
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A 25-year-old man is stabbed in the chest about 10cm below the left nipple. Upon arrival at the emergency department, an abdominal ultrasound scan reveals a significant amount of intraperitoneal bleeding. Which of the following statements regarding the probable location of the injury is false?
Your Answer: The quadrate lobe is contained within the functional right lobe.
Explanation:The most probable location of injury in the liver is the right lobe. Hence, option B is the correct answer as the quadrate lobe is considered as a functional part of the left lobe. The liver is mostly covered by peritoneum, except for the bare area at the back. The right lobe of the liver has the largest bare area and is also bigger than the left lobe.
Structure and Relations of the Liver
The liver is divided into four lobes: the right lobe, left lobe, quadrate lobe, and caudate lobe. The right lobe is supplied by the right hepatic artery and contains Couinaud segments V to VIII, while the left lobe is supplied by the left hepatic artery and contains Couinaud segments II to IV. The quadrate lobe is part of the right lobe anatomically but functionally is part of the left, and the caudate lobe is supplied by both right and left hepatic arteries and lies behind the plane of the porta hepatis. The liver lobules are separated by portal canals that contain the portal triad: the hepatic artery, portal vein, and tributary of bile duct.
The liver has various relations with other organs in the body. Anteriorly, it is related to the diaphragm, esophagus, xiphoid process, stomach, duodenum, hepatic flexure of colon, right kidney, gallbladder, and inferior vena cava. The porta hepatis is located on the postero-inferior surface of the liver and transmits the common hepatic duct, hepatic artery, portal vein, sympathetic and parasympathetic nerve fibers, and lymphatic drainage of the liver and nodes.
The liver is supported by ligaments, including the falciform ligament, which is a two-layer fold of peritoneum from the umbilicus to the anterior liver surface and contains the ligamentum teres (remnant of the umbilical vein). The ligamentum venosum is a remnant of the ductus venosus. The liver is supplied by the hepatic artery and drained by the hepatic veins and portal vein. Its nervous supply comes from the sympathetic and parasympathetic trunks of the coeliac plexus.
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This question is part of the following fields:
- Gastrointestinal System
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Question 40
Correct
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A 54-year-old man presents to the emergency department with complaints of nausea and vomiting that started 3 hours ago. The vomit contains some food content but no blood. He also reports experiencing abdominal pain, but is unable to pinpoint the location. On examination, his heart rate is 90 beats per minute, respiratory rate is 20 breaths per minute, and blood pressure is 140/88 mmHg. The emergency physician observes that he has red palms and ascites in his abdomen. The following blood results are obtained:
- Hemoglobin: 128 g/L
- Aspartate aminotransferase (AST): 82 U/L
- Alanine aminotransferase (ALT): 38 U/L
Further questioning reveals that the man used to engage in binge drinking and currently consumes more than 60 units of alcohol per week since his divorce 15 years ago and recent job loss. Based on this information, what pathological feature is likely to be observed on liver biopsy?Your Answer: Excess collagen and extracellular matrix deposition in periportal and pericentral zones leading to the formation of regenerative nodules
Explanation:Patients with this condition typically exhibit the presence of anti-mitochondrial antibodies.
Scoring Systems for Liver Cirrhosis
Liver cirrhosis is a serious condition that can lead to liver failure and death. To assess the severity of the disease, doctors use scoring systems such as the Child-Pugh classification and the Model for End-Stage Liver Disease (MELD). The Child-Pugh classification takes into account five factors: bilirubin levels, albumin levels, prothrombin time, encephalopathy, and ascites. Each factor is assigned a score of 1 to 3, depending on its severity, and the scores are added up to give a total score. The total score is then used to grade the severity of the disease as A, B, or C.
The MELD system uses a formula that takes into account a patient’s bilirubin, creatinine, and international normalized ratio (INR) to predict their survival. The formula calculates a score that ranges from 6 to 40, with higher scores indicating a higher risk of mortality. The MELD score is particularly useful for patients who are on a liver transplant waiting list, as it helps to prioritize patients based on their risk of mortality. Overall, both the Child-Pugh classification and the MELD system are important tools for assessing the severity of liver cirrhosis and determining the best course of treatment for patients.
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This question is part of the following fields:
- Gastrointestinal System
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Question 41
Incorrect
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A 45-year-old woman with a family history of multiple endocrine neoplasia type 1 visits her GP complaining of upper abdominal pain. She reports experiencing worsening dyspepsia after meals for the past three months. Upon further questioning, she discloses that she has had loose stools and unintentionally lost approximately one stone in weight during this time.
What is the typical physiological function of the hormone that is accountable for this patient's symptoms?Your Answer: Suppress the release of pancreatic enzymes
Correct Answer: Increase H+ secretion by gastric parietal cells
Explanation:The correct answer is that gastrin increases the secretion of H+ by gastric parietal cells. This patient is suffering from Zollinger-Ellison syndrome due to a gastrinoma, which results in excessive production of gastrin and an overly acidic environment in the duodenum. This leads to symptoms such as dyspepsia, diarrhoea, and weight loss, as the intestinal pH is no longer optimal for digestion. The patient’s family history of multiple endocrine neoplasia type 1 is also a clue, as this condition is associated with around 25% of gastrinomas. Gastrin’s normal function is to increase the secretion of H+ by gastric parietal cells to aid in digestion.
The options delay gastric emptying, increase H+ secretion by gastric chief cells, and stimulate pancreatic bicarbonate secretion are incorrect. Gastrin’s role is to promote digestion and increase gastric emptying, not delay it. Gastric chief cells secrete pepsinogen and gastric lipase to aid in protein and fat digestion, not H+. Finally, pancreatic bicarbonate secretion is stimulated by secretin, which is produced by duodenal S-cells, not gastrin.
Overview of Gastrointestinal Hormones
Gastrointestinal hormones play a crucial role in the digestion and absorption of food. These hormones are secreted by various cells in the stomach and small intestine in response to different stimuli such as the presence of food, pH changes, and neural signals.
One of the major hormones involved in food digestion is gastrin, which is secreted by G cells in the antrum of the stomach. Gastrin increases acid secretion by gastric parietal cells, stimulates the secretion of pepsinogen and intrinsic factor, and increases gastric motility. Another hormone, cholecystokinin (CCK), is secreted by I cells in the upper small intestine in response to partially digested proteins and triglycerides. CCK increases the secretion of enzyme-rich fluid from the pancreas, contraction of the gallbladder, and relaxation of the sphincter of Oddi. It also decreases gastric emptying and induces satiety.
Secretin is another hormone secreted by S cells in the upper small intestine in response to acidic chyme and fatty acids. Secretin increases the secretion of bicarbonate-rich fluid from the pancreas and hepatic duct cells, decreases gastric acid secretion, and has a trophic effect on pancreatic acinar cells. Vasoactive intestinal peptide (VIP) is a neural hormone that stimulates secretion by the pancreas and intestines and inhibits acid secretion.
Finally, somatostatin is secreted by D cells in the pancreas and stomach in response to fat, bile salts, and glucose in the intestinal lumen. Somatostatin decreases acid and pepsin secretion, decreases gastrin secretion, decreases pancreatic enzyme secretion, and decreases insulin and glucagon secretion. It also inhibits the trophic effects of gastrin and stimulates gastric mucous production.
In summary, gastrointestinal hormones play a crucial role in regulating the digestive process and maintaining homeostasis in the gastrointestinal tract.
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This question is part of the following fields:
- Gastrointestinal System
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Question 42
Correct
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A 50-year-old woman is having a Whipple procedure for pancreatic head cancer, with transection of the bile duct. Which vessel is primarily responsible for supplying blood to the bile duct?
Your Answer: Hepatic artery
Explanation:It is important to distinguish between the blood supply of the bile duct and that of the cystic duct. The bile duct receives its blood supply from the hepatic artery and retroduodenal branches of the gastroduodenal artery, while the portal vein does not contribute to its blood supply. In cases of difficult cholecystectomy, damage to the hepatic artery can lead to bile duct strictures.
The gallbladder is a sac made of fibromuscular tissue that can hold up to 50 ml of fluid. Its lining is made up of columnar epithelium. The gallbladder is located in close proximity to various organs, including the liver, transverse colon, and the first part of the duodenum. It is covered by peritoneum and is situated between the right lobe and quadrate lobe of the liver. The gallbladder receives its arterial supply from the cystic artery, which is a branch of the right hepatic artery. Its venous drainage is directly to the liver, and its lymphatic drainage is through Lund’s node. The gallbladder is innervated by both sympathetic and parasympathetic nerves. The common bile duct originates from the confluence of the cystic and common hepatic ducts and is located in the hepatobiliary triangle, which is bordered by the common hepatic duct, cystic duct, and the inferior edge of the liver. The cystic artery is also found within this triangle.
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This question is part of the following fields:
- Gastrointestinal System
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Question 43
Correct
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A healthy 56-year-old woman attends her flexible sigmoidoscopy as part of the UK's national screening program. While performing the procedure, the surgeon observes and biopsies several polyps for further analysis. Additionally, the patient has multiple hyperpigmented macules on her lips.
During her follow-up visit, the patient is informed that the type of polyp found in her bowel increases her risk of developing cancers in other parts of her body.
What is the name of the benign colorectal tumor that the patient has?Your Answer: Peutz-Jeghers polyps
Explanation:Understanding Peutz-Jeghers Syndrome
Peutz-Jeghers syndrome is a genetic condition that is inherited in an autosomal dominant manner. It is characterized by the presence of numerous hamartomatous polyps in the gastrointestinal tract, particularly in the small bowel. In addition, patients with this syndrome may also have pigmented freckles on their lips, face, palms, and soles.
While the polyps themselves are not cancerous, individuals with Peutz-Jeghers syndrome have an increased risk of developing other types of gastrointestinal tract cancers. In fact, around 50% of patients will have died from another gastrointestinal tract cancer by the age of 60 years.
Common symptoms of Peutz-Jeghers syndrome include small bowel obstruction, which is often due to intussusception, as well as gastrointestinal bleeding. Management of this condition is typically conservative unless complications develop. It is important for individuals with Peutz-Jeghers syndrome to undergo regular screening and surveillance to detect any potential cancerous growths early on.
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This question is part of the following fields:
- Gastrointestinal System
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Question 44
Correct
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A 54-year-old man undergoes an abdomino-perineal excision of the colon and rectum and is now experiencing impotence. What is the probable cause?
Your Answer: Damage to the hypogastric plexus during mobilisation of the inferior mesenteric artery
Explanation:The most frequent cause is injury to the autonomic nerves.
During surgical procedures, there is a risk of nerve injury caused by the surgery itself. This is not only important for the patient’s well-being but also from a legal perspective. There are various operations that carry the risk of nerve damage, such as posterior triangle lymph node biopsy, Lloyd Davies stirrups, thyroidectomy, anterior resection of rectum, axillary node clearance, inguinal hernia surgery, varicose vein surgery, posterior approach to the hip, and carotid endarterectomy. Surgeons must have a good understanding of the anatomy of the area they are operating on to minimize the incidence of nerve lesions. Blind placement of haemostats is not recommended as it can also cause nerve damage.
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This question is part of the following fields:
- Gastrointestinal System
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Question 45
Correct
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A 72-year-old man presents to you, his primary care physician, after being treated for acute pancreatitis in the hospital. A contrast CT scan conducted during his stay revealed several small blind-ended pouches in the sigmoid colon. These pouches do not appear to be causing any symptoms.
What is the diagnosis?Your Answer: Diverticulosis
Explanation:Diverticulosis refers to the presence of diverticula in the colon without any symptoms.
Diverticulosis is a common condition where multiple outpouchings occur in the bowel wall, typically in the sigmoid colon. It is more accurate to use the term diverticulosis when referring to the presence of diverticula, while diverticular disease is reserved for symptomatic patients. Risk factors for this condition include a low-fibre diet and increasing age. Symptoms of diverticulosis can include altered bowel habits and colicky left-sided abdominal pain. A high-fibre diet is often recommended to alleviate these symptoms.
Diverticulitis is a complication of diverticulosis where one of the diverticula becomes infected. The typical presentation includes left iliac fossa pain and tenderness, anorexia, nausea, vomiting, diarrhea, and signs of infection such as pyrexia, raised WBC, and CRP. Mild attacks can be treated with oral antibiotics, while more severe episodes require hospitalization. Treatment involves nil by mouth, intravenous fluids, and intravenous antibiotics such as a cephalosporin and metronidazole. Complications of diverticulitis include abscess formation, peritonitis, obstruction, and perforation.
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This question is part of the following fields:
- Gastrointestinal System
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Question 46
Correct
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A 33-year-old man visits his doctor with complaints of occasional rectal bleeding, diarrhea, and fatigue. He reports that his symptoms have been progressively worsening for the past year, and he is worried because his father was diagnosed with colorectal cancer at the age of 56.
Upon referral for a colonoscopy, the patient is found to have numerous benign polyps in his large colon.
Which gene mutation is linked to this condition?Your Answer: APC
Explanation:Familial adenomatous polyposis (FAP) is caused by a mutation in the adenomatous polyposis coli gene (APC), which is a tumour suppressor gene. This hereditary condition is characterised by the presence of numerous benign polyps in the colon, which increases the risk of developing colon cancer. Cystic fibrosis is caused by a mutation in the CFTR gene, which is not related to the symptoms of FAP. Hereditary non-polyposis colorectal cancer (HNPCC) is associated with mutations in DNA mismatch repair genes such as MLH1, but it does not involve the development of numerous benign polyps. Li-Fraumeni syndrome is a rare disease caused by a mutation in the TP53 tumour suppressor gene, which is associated with the development of various cancers. Gilbert’s syndrome is caused by a mutation in a different gene and is not related to FAP.
Colorectal cancer can be classified into three types: sporadic, hereditary non-polyposis colorectal carcinoma (HNPCC), and familial adenomatous polyposis (FAP). Sporadic colon cancer is believed to be caused by a series of genetic mutations, including allelic loss of the APC gene, activation of the K-ras oncogene, and deletion of p53 and DCC tumor suppressor genes. HNPCC, which is an autosomal dominant condition, is the most common form of inherited colon cancer. It is caused by mutations in genes involved in DNA mismatch repair, leading to microsatellite instability. The most common genes affected are MSH2 and MLH1. Patients with HNPCC are also at a higher risk of other cancers, such as endometrial cancer. The Amsterdam criteria are sometimes used to aid diagnosis of HNPCC. FAP is a rare autosomal dominant condition that leads to the formation of hundreds of polyps by the age of 30-40 years. It is caused by a mutation in the APC gene. Patients with FAP are also at risk of duodenal tumors. A variant of FAP called Gardner’s syndrome can also feature osteomas of the skull and mandible, retinal pigmentation, thyroid carcinoma, and epidermoid cysts on the skin. Genetic testing can be done to diagnose HNPCC and FAP, and patients with FAP generally have a total colectomy with ileo-anal pouch formation in their twenties.
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This question is part of the following fields:
- Gastrointestinal System
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Question 47
Incorrect
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An elderly man, aged 72, visits his family doctor with complaints of a vague abdominal pain that has been bothering him for the past few months. He is unable to pinpoint the exact location of the pain but mentions that it is more severe around the epigastric region. The pain worsens after meals and has resulted in a loss of appetite and recent weight loss. The man denies experiencing any nausea or vomiting and reports only mild constipation. He has a long-standing history of type 2 diabetes mellitus, hypertension, and dyslipidemia and is currently taking glipizide, insulin injections, atorvastatin, candesartan, and metoprolol as regular medications. Additionally, he is a current smoker with a 25 pack-year history. On examination, the abdomen is soft and non-tender. The man’s vital signs include a heart rate of 62 beats per minute, respiratory rate of 13 breaths per minute, and blood pressure of 147/91 mmHg. What is the most likely mechanism responsible for this patient’s symptoms?
Your Answer: Ectopic gastric mucosal tissue secreting gastric acid
Correct Answer: Fatty accumulation, foam cell formation and fibrous plaque formation in the wall of blood vessels
Explanation:The patient’s symptoms suggest that he may have chronic mesenteric ischemia, which is often caused by atherosclerosis in the arteries supplying the splanchnic circulatory vessels. There is no indication of recent abdominal surgery or an underlying inflammatory process. Constipation is a common issue in elderly individuals, but it is not typically associated with abdominal pain. Meckel diverticulum is a congenital defect that can cause symptoms such as melaena, acute appendicitis, and acute abdominal pain due to ectopic acid secretion. Diverticulitis is characterized by inflammation in the colon, often due to a lack of dietary fiber. Small bowel obstruction due to adhesions is a surgical emergency. Chronic mesenteric ischemia, also known as intestinal angina, is common in individuals with atherosclerotic diseases such as diabetics, smokers, hypertensive patients, and those with dyslipidemia. As the population ages and chronic diseases become more prevalent, the incidence and prevalence of chronic mesenteric ischemia are expected to increase.
Ischaemia to the lower gastrointestinal tract can result in acute mesenteric ischaemia, chronic mesenteric ischaemia, and ischaemic colitis. Common predisposing factors include increasing age, atrial fibrillation, other causes of emboli, cardiovascular disease risk factors, and cocaine use. Common features include abdominal pain, rectal bleeding, diarrhea, fever, and elevated white blood cell count with lactic acidosis. CT is the investigation of choice. Acute mesenteric ischaemia is typically caused by an embolism and requires urgent surgery. Chronic mesenteric ischaemia presents with intermittent abdominal pain. Ischaemic colitis is an acute but transient compromise in blood flow to the large bowel and may require surgery in a minority of cases.
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This question is part of the following fields:
- Gastrointestinal System
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Question 48
Incorrect
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A 40-year-old male presents with a six-month history of frequent diarrhoea. He describes up to ten episodes a day of bloody stool. The patient denies any night sweats, fever, or weight loss, explains that he has not changed his diet recently.
On examination he has;
Normal vital signs
No ulcerations in his mouth
Mild lower abdominal tenderness
Pain and blood noted on rectal examination
What is the most probable finding on colonoscopy or biopsy?Your Answer: Increased goblet cells
Correct Answer: Crypt abscesses
Explanation:ASCA, also known as anti-Saccharomyces cerevisiae antibodies, can be abbreviated as 6.
Inflammatory bowel disease (IBD) is a condition that includes two main types: Crohn’s disease and ulcerative colitis. Although they share many similarities in terms of symptoms, diagnosis, and treatment, there are some key differences between the two. Crohn’s disease is characterized by non-bloody diarrhea, weight loss, upper gastrointestinal symptoms, mouth ulcers, perianal disease, and a palpable abdominal mass in the right iliac fossa. On the other hand, ulcerative colitis is characterized by bloody diarrhea, abdominal pain in the left lower quadrant, tenesmus, gallstones, and primary sclerosing cholangitis. Complications of Crohn’s disease include obstruction, fistula, and colorectal cancer, while ulcerative colitis has a higher risk of colorectal cancer than Crohn’s disease. Pathologically, Crohn’s disease lesions can be seen anywhere from the mouth to anus, while ulcerative colitis inflammation always starts at the rectum and never spreads beyond the ileocaecal valve. Endoscopy and radiology can help diagnose and differentiate between the two types of IBD.
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This question is part of the following fields:
- Gastrointestinal System
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Question 49
Correct
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A 16-year-old boy is diagnosed with Meckel's diverticulum. What embryological structure does it originate from?
Your Answer: Vitello-intestinal duct
Explanation:The Meckel’s diverticulum is a condition where the vitello-intestinal duct persists, and it is characterized by being 2 inches (5cm) long, located 2 feet (60 cm) from the ileocaecal valve, 2 times more common in men, and involving 2 tissue types.
Meckel’s diverticulum is a congenital diverticulum of the small intestine that is a remnant of the omphalomesenteric duct. It occurs in 2% of the population, is 2 feet from the ileocaecal valve, and is 2 inches long. It is usually asymptomatic but can present with abdominal pain, rectal bleeding, or intestinal obstruction. Investigation includes a Meckel’s scan or mesenteric arteriography. Management involves removal if narrow neck or symptomatic, with options between wedge excision or formal small bowel resection and anastomosis. Meckel’s diverticulum is typically lined by ileal mucosa but ectopic gastric, pancreatic, and jejunal mucosa can also occur.
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This question is part of the following fields:
- Gastrointestinal System
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Question 50
Incorrect
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A 65-year-old man visits his GP complaining of a lump in his groin. He reports no other symptoms such as abdominal pain or changes in bowel habits. Upon examination, the GP notes that the lump is soft and can be reduced without causing discomfort to the patient. The GP suspects an inguinal hernia but is unsure if it is direct or indirect. To determine this, the GP reduces the lump and applies pressure to the anatomical landmark for the deep inguinal ring. What is this landmark?
Your Answer: Superior and medial to the pubic tubercle
Correct Answer: Superior to the midpoint of the inguinal ligament
Explanation:The inguinal canal is located above the inguinal ligament and measures 4 cm in length. Its superficial ring is situated in front of the pubic tubercle, while the deep ring is found about 1.5-2 cm above the halfway point between the anterior superior iliac spine and the pubic tubercle. The canal is bounded by the external oblique aponeurosis, inguinal ligament, lacunar ligament, internal oblique, transversus abdominis, external ring, and conjoint tendon. In males, the canal contains the spermatic cord and ilioinguinal nerve, while in females, it houses the round ligament of the uterus and ilioinguinal nerve.
The boundaries of Hesselbach’s triangle, which are frequently tested, are located in the inguinal region. Additionally, the inguinal canal is closely related to the vessels of the lower limb, which should be taken into account when repairing hernial defects in this area.
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This question is part of the following fields:
- Gastrointestinal System
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Question 51
Correct
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Which enzyme is primarily responsible for breaking down starch into sugars?
Your Answer: Amylase
Explanation:Amylase is an enzyme that converts starch into sugars.
Enzymes play a crucial role in the breakdown of carbohydrates in the gastrointestinal system. Amylase, which is present in both saliva and pancreatic secretions, is responsible for breaking down starch into sugar. On the other hand, brush border enzymes such as maltase, sucrase, and lactase are involved in the breakdown of specific disaccharides. Maltase cleaves maltose into glucose and glucose, sucrase cleaves sucrose into fructose and glucose, while lactase cleaves lactose into glucose and galactose. These enzymes work together to ensure that carbohydrates are broken down into their simplest form for absorption into the bloodstream.
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This question is part of the following fields:
- Gastrointestinal System
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Question 52
Correct
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A 65-year-old man arrives at the Emergency Department after collapsing at home. According to his wife, he had complained of sudden lower back pain just before the collapse. Upon examination, he appears pale and hypotensive, leading you to suspect a ruptured abdominal aortic aneurysm. Can you determine at which level the affected structure terminates?
Your Answer: L4
Explanation:The section of the aorta that runs through the abdomen, known as the abdominal aorta, extends from the T12 vertebrae to the L4 vertebrae. This area is particularly susceptible to developing an aneurysm, which is most commonly seen in men over the age of 65. Risk factors for abdominal aortic aneurysms include smoking, diabetes, high blood pressure, and high cholesterol levels. Symptoms are often absent until the aneurysm ruptures, causing sudden and severe pain in the lower back or abdomen, as well as a drop in blood pressure and consciousness. To detect potential aneurysms, the NHS offers a one-time ultrasound screening for men over the age of 65 who have not previously been screened.
The abdominal aorta is a major blood vessel that originates from the 12th thoracic vertebrae and terminates at the fourth lumbar vertebrae. It is located in the abdomen and is surrounded by various organs and structures. The posterior relations of the abdominal aorta include the vertebral bodies of the first to fourth lumbar vertebrae. The anterior relations include the lesser omentum, liver, left renal vein, inferior mesenteric vein, third part of the duodenum, pancreas, parietal peritoneum, and peritoneal cavity. The right lateral relations include the right crus of the diaphragm, cisterna chyli, azygos vein, and inferior vena cava (which becomes posterior distally). The left lateral relations include the fourth part of the duodenum, duodenal-jejunal flexure, and left sympathetic trunk. Overall, the abdominal aorta is an important blood vessel that supplies oxygenated blood to various organs in the abdomen.
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This question is part of the following fields:
- Gastrointestinal System
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Question 53
Correct
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A 16-year-old presents to the Emergency Department with her father, who has noticed a yellowish tint to her eyes. Upon further inquiry, she reports having a flu-like illness a few days ago, which has since resolved. She has no medical history and is not taking any medications. On examination, scleral icterus is the only significant finding. The following are her blood test results:
Hb 130 g/L Male: (135-180) Female: (115 - 160)
Platelets 320 * 109/L (150 - 400)
WBC 6.0 * 109/L (4.0 - 11.0)
Bilirubin 80 µmol/L (3 - 17)
ALP 42 u/L (30 - 100)
ALT 30 u/L (3 - 40)
γGT 50 u/L (8 - 60)
Albumin 45 g/L (35 - 50)
What is the most probable cause of her symptoms?Your Answer: Gilbert's syndrome
Explanation:Gilbert’s syndrome is characterized by an inherited deficiency of an enzyme used to conjugate bilirubin, resulting in elevated levels of unconjugated bilirubin in the blood. This can lead to isolated jaundice of the sclera or mouth during times of physiological stress.
Crigler Najjar syndrome, on the other hand, is a rare genetic disorder that causes an inability to convert and clear bilirubin from the body, resulting in jaundice shortly after birth.
Gallstones, which can be asymptomatic or present with right upper quadrant pain following a meal, are associated with risk factors such as being overweight, over 40 years old, female, or fertile.
Primary sclerosing cholangitis (PSC) is characterized by scarring and fibrosis of the bile ducts inside and outside the liver, and may occur alone or in combination with inflammatory diseases such as ulcerative colitis. Symptoms of PSC include jaundice, right upper quadrant pain, itching, fatigue, and weight loss.
Gilbert’s syndrome is a genetic disorder that affects the way bilirubin is processed in the body. It is caused by a deficiency of UDP glucuronosyltransferase, which leads to unconjugated hyperbilirubinemia. This means that bilirubin is not properly broken down and eliminated from the body, resulting in jaundice. However, jaundice may only be visible during certain conditions such as fasting, exercise, or illness. The prevalence of Gilbert’s syndrome is around 1-2% in the general population.
To diagnose Gilbert’s syndrome, doctors may look for a rise in bilirubin levels after prolonged fasting or the administration of IV nicotinic acid. However, treatment is not necessary for this condition. While the exact mode of inheritance is still debated, it is known to be an autosomal recessive disorder.
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This question is part of the following fields:
- Gastrointestinal System
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Question 54
Correct
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A 36-year-old woman is found to have an aggressive caecal adenocarcinoma. Her sister passed away from the same disease at 39 years of age. Her mother died from endometrial cancer at the age of 42. What genetic abnormality is the most probable cause of this family's cancer history?
Your Answer: Mutation of mismatch repair genes
Explanation:Microsatellite instability of DNA repair genes causes Lynch syndrome, which is identified by the presence of aggressive colon cancer on the right side and endometrial cancer.
Colorectal cancer can be classified into three types: sporadic, hereditary non-polyposis colorectal carcinoma (HNPCC), and familial adenomatous polyposis (FAP). Sporadic colon cancer is believed to be caused by a series of genetic mutations, including allelic loss of the APC gene, activation of the K-ras oncogene, and deletion of p53 and DCC tumor suppressor genes. HNPCC, which is an autosomal dominant condition, is the most common form of inherited colon cancer. It is caused by mutations in genes involved in DNA mismatch repair, leading to microsatellite instability. The most common genes affected are MSH2 and MLH1. Patients with HNPCC are also at a higher risk of other cancers, such as endometrial cancer. The Amsterdam criteria are sometimes used to aid diagnosis of HNPCC. FAP is a rare autosomal dominant condition that leads to the formation of hundreds of polyps by the age of 30-40 years. It is caused by a mutation in the APC gene. Patients with FAP are also at risk of duodenal tumors. A variant of FAP called Gardner’s syndrome can also feature osteomas of the skull and mandible, retinal pigmentation, thyroid carcinoma, and epidermoid cysts on the skin. Genetic testing can be done to diagnose HNPCC and FAP, and patients with FAP generally have a total colectomy with ileo-anal pouch formation in their twenties.
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This question is part of the following fields:
- Gastrointestinal System
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Question 55
Correct
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A 75-year-old woman comes to the clinic with a painful lump in her right groin. Upon examination, a tender swelling is found below and to the side of the pubic tubercle. It exhibits a cough impulse. What is the probable underlying diagnosis?
Your Answer: Femoral hernia
Explanation:Although a saphena varix thrombophlebitis can result in a sensitive bulge in the affected area, it typically does not produce a cough impulse.
Understanding the Femoral Canal
The femoral canal is a fascial tunnel located at the medial aspect of the femoral sheath. It contains both the femoral artery and femoral vein, with the canal lying medial to the vein. The borders of the femoral canal include the femoral vein laterally, the lacunar ligament medially, the inguinal ligament anteriorly, and the pectineal ligament posteriorly.
The femoral canal plays a significant role in allowing the femoral vein to expand, which facilitates increased venous return to the lower limbs. However, it can also be a site of femoral hernias, which occur when abdominal contents protrude through the femoral canal. The relatively tight neck of the femoral canal places these hernias at high risk of strangulation, making it important to understand the anatomy and function of this structure. Overall, understanding the femoral canal is crucial for medical professionals in diagnosing and treating potential issues related to this area.
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This question is part of the following fields:
- Gastrointestinal System
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Question 56
Correct
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A 3-year-old girl is brought to the emergency department due to severe abdominal pain. She has tenderness throughout her abdomen, but it is especially painful in the right iliac fossa. Her parents are concerned because they noticed blood in her stool earlier today.
The patient is admitted and receives appropriate treatment. Further investigations reveal the presence of ectopic ileal mucosa.
What is the probable underlying condition?Your Answer: Meckel's diverticulum
Explanation:Meckel’s diverticulum is the most likely diagnosis for this child’s symptoms. It is a congenital condition that affects about 2% of the population and typically presents with symptoms around the age of 2. Some children with Meckel’s diverticulum may develop diverticulitis, which can be mistaken for appendicitis. The presence of ectopic ileal mucosa is a key factor in diagnosing Meckel’s diverticulum.
Appendicitis is an unlikely diagnosis as it would not explain the presence of ectopic ileal mucosa. Duodenal atresia is also unlikely as it typically presents in newborns and is associated with Down’s syndrome. Necrotising enterocolitis is another unlikely diagnosis as it primarily affects premature infants and would not explain the ectopic ileal mucosa.
Meckel’s diverticulum is a congenital diverticulum of the small intestine that is a remnant of the omphalomesenteric duct. It occurs in 2% of the population, is 2 feet from the ileocaecal valve, and is 2 inches long. It is usually asymptomatic but can present with abdominal pain, rectal bleeding, or intestinal obstruction. Investigation includes a Meckel’s scan or mesenteric arteriography. Management involves removal if narrow neck or symptomatic, with options between wedge excision or formal small bowel resection and anastomosis. Meckel’s diverticulum is typically lined by ileal mucosa but ectopic gastric, pancreatic, and jejunal mucosa can also occur.
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This question is part of the following fields:
- Gastrointestinal System
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Question 57
Correct
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An 80-year-old woman presents to the GP with a complaint of dull abdominal pain that has been bothering her for the past 3 months. The pain is usually worse on the left side and sometimes eases after passing stool. She also reports having more diarrhea than usual. Last week, she had an episode of fresh red bleeding from the back passage. She denies any changes in her diet and has a past medical history of total abdominal hysterectomy, osteoarthritis, and basal cell carcinoma. On examination, her abdomen is mildly tender in the left iliac fossa, and rectal examination is normal. Her BMI is 27 kg/m², and she drinks a large whisky every evening. The GP urgently refers her for investigations, and she is diagnosed with diverticulosis. What feature of her history puts her at the greatest risk for diverticulosis?
Your Answer: Low-fibre diet
Explanation:Intestinal diverticula are more likely to develop in individuals with a low fibre diet. This patient’s diet appears to be lacking in fruits and vegetables, which increases their risk. While smoking has been linked to diverticulosis, there is no evidence to suggest that alcohol consumption is a risk factor. Although obesity is associated with an increased risk, this patient’s BMI is not in the obese range. Diverticulosis is more prevalent in men than women, and abdominal surgery is not a known risk factor.
Diverticulosis is a common condition where multiple outpouchings occur in the bowel wall, typically in the sigmoid colon. It is more accurate to use the term diverticulosis when referring to the presence of diverticula, while diverticular disease is reserved for symptomatic patients. Risk factors for this condition include a low-fibre diet and increasing age. Symptoms of diverticulosis can include altered bowel habits and colicky left-sided abdominal pain. A high-fibre diet is often recommended to alleviate these symptoms.
Diverticulitis is a complication of diverticulosis where one of the diverticula becomes infected. The typical presentation includes left iliac fossa pain and tenderness, anorexia, nausea, vomiting, diarrhea, and signs of infection such as pyrexia, raised WBC, and CRP. Mild attacks can be treated with oral antibiotics, while more severe episodes require hospitalization. Treatment involves nil by mouth, intravenous fluids, and intravenous antibiotics such as a cephalosporin and metronidazole. Complications of diverticulitis include abscess formation, peritonitis, obstruction, and perforation.
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This question is part of the following fields:
- Gastrointestinal System
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Question 58
Correct
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A 50-year-old man comes to the clinic with bilateral inguinal hernias. The surgical team plans to perform a laparoscopic extraperitoneal repair. During the procedure, the surgeons make an infraumbilical incision and move the inferior part of the rectus abdominis muscle forward to insert a prosthetic mesh for hernia repair. What anatomical structure will be located behind the mesh?
Your Answer: Peritoneum
Explanation:In a TEP repair of inguinal hernia, the peritoneum is the only structure located behind the mesh. The query specifically pertains to the structure situated behind the rectus abdominis muscle. As this area is situated below the arcuate line, the transversalis fascia and peritoneum are positioned behind it.
The rectus sheath is a structure formed by the aponeuroses of the lateral abdominal wall muscles. Its composition varies depending on the anatomical level. Above the costal margin, the anterior sheath is made up of the external oblique aponeurosis, with the costal cartilages located behind it. From the costal margin to the arcuate line, the anterior rectus sheath is composed of the external oblique aponeurosis and the anterior part of the internal oblique aponeurosis. The posterior rectus sheath is formed by the posterior part of the internal oblique aponeurosis and transversus abdominis. Below the arcuate line, all the abdominal muscle aponeuroses are located in the anterior aspect of the rectus sheath, while the transversalis fascia and peritoneum are located posteriorly. The arcuate line is the point where the inferior epigastric vessels enter the rectus sheath.
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This question is part of the following fields:
- Gastrointestinal System
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Question 59
Incorrect
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You are present during the colonoscopy of a middle-aged patient who is being investigated by gastroenterology due to experiencing severe abdominal pain and passing bloody stools multiple times a day for several weeks. Although the symptoms have subsided, the patient also complains of significant joint pain and has had episodes of painful, red left eye with blurry vision. The consultant suspects ulcerative colitis as the probable diagnosis and performs a biopsy during the procedure to confirm it. What feature would most likely confirm the consultant's suspicions?
Your Answer: Crypt hyperplasia
Correct Answer: Crypt abscesses
Explanation:Ulcerative colitis is a chronic inflammatory bowel disease that can cause various symptoms, including ocular manifestations such as anterior uveitis. A biopsy of affected tissue is crucial in diagnosing ulcerative colitis and distinguishing it from other similar conditions, particularly Crohn’s disease. The characteristic microscopic features of ulcerative colitis include crypt abscesses and pseudopolyps. Partial villous atrophy is not typically associated with ulcerative colitis but may be seen in tropical sprue. Crypt hyperplasia and complete villous atrophy are more commonly seen in coeliac disease. Non-caseating granulomas and transmural inflammation are typical histological features of Crohn’s disease, which is the primary differential diagnosis for ulcerative colitis.
Inflammatory bowel disease (IBD) is a condition that includes two main types: Crohn’s disease and ulcerative colitis. Although they share many similarities in terms of symptoms, diagnosis, and treatment, there are some key differences between the two. Crohn’s disease is characterized by non-bloody diarrhea, weight loss, upper gastrointestinal symptoms, mouth ulcers, perianal disease, and a palpable abdominal mass in the right iliac fossa. On the other hand, ulcerative colitis is characterized by bloody diarrhea, abdominal pain in the left lower quadrant, tenesmus, gallstones, and primary sclerosing cholangitis. Complications of Crohn’s disease include obstruction, fistula, and colorectal cancer, while ulcerative colitis has a higher risk of colorectal cancer than Crohn’s disease. Pathologically, Crohn’s disease lesions can be seen anywhere from the mouth to anus, while ulcerative colitis inflammation always starts at the rectum and never spreads beyond the ileocaecal valve. Endoscopy and radiology can help diagnose and differentiate between the two types of IBD.
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This question is part of the following fields:
- Gastrointestinal System
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Question 60
Correct
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A 32-year-old man visits his GP reporting a recent onset tremor, along with difficulties in coordination, slurred speech, and deteriorating handwriting. The patient denies experiencing any weakness, visual impairment, or dizziness. Following a battery of blood tests, the diagnosis of Wilson's disease is confirmed.
Which region of the brain is typically impacted in this disorder?Your Answer: Basal ganglia
Explanation:Wilson’s disease causes elevated copper levels in the body, leading to deposits in various organs, with the basal ganglia in the brain being the most commonly affected. Damage to this structure results in symptoms. Broca’s area in the frontal lobe is involved in language production and is commonly affected in stroke. The midbrain is involved in consciousness and movement, while the motor cortex is involved in planning and executing movement. The ventricles are fluid-filled spaces involved in cerebrospinal fluid movement and formation.
Understanding Wilson’s Disease
Wilson’s disease is a genetic disorder that causes excessive copper accumulation in the tissues due to metabolic abnormalities. It is an autosomal recessive disorder caused by a defect in the ATP7B gene located on chromosome 13. Symptoms usually appear between the ages of 10 to 25 years, with children presenting with liver disease and young adults with neurological disease.
The disease is characterised by excessive copper deposition in the tissues, particularly in the brain, liver, and cornea. This can lead to a range of symptoms, including hepatitis, cirrhosis, basal ganglia degeneration, speech and behavioural problems, asterixis, chorea, dementia, parkinsonism, Kayser-Fleischer rings, renal tubular acidosis, haemolysis, and blue nails.
To diagnose Wilson’s disease, doctors may perform a slit lamp examination for Kayser-Fleischer rings, measure serum ceruloplasmin and total serum copper (which is often reduced), and check for increased 24-hour urinary copper excretion. Genetic analysis of the ATP7B gene can confirm the diagnosis.
Treatment for Wilson’s disease typically involves chelating agents such as penicillamine or trientine hydrochloride, which help to remove excess copper from the body. Tetrathiomolybdate is a newer agent that is currently under investigation. With proper management, individuals with Wilson’s disease can lead normal lives.
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This question is part of the following fields:
- Gastrointestinal System
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Question 61
Correct
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A 32-year-old female presents to her GP with complaints of chronic fatigue, bloating, and intermittent diarrhea. She denies any recent changes in her diet, rectal bleeding, or weight loss. Upon physical examination, no abnormalities are detected. Further investigations reveal the following results: Hb 95g/L (Female: 115-160), Platelets 200 * 109/L (150-400), WBC 6.2 * 109/L (4.0-11.0), and raised IgA-tTG serology. What additional test should the GP arrange to confirm the likely diagnosis?
Your Answer: Endoscopic intestinal biopsy
Explanation:The preferred method for diagnosing coeliac disease is through an endoscopic intestinal biopsy, which is considered the gold standard. This should be performed if there is suspicion of the condition based on serology results. While endomysial antibody testing can be useful, it is more expensive and not as preferred as the biopsy. A stomach biopsy would not be helpful in diagnosing coeliac disease, as the condition affects the cells in the intestine. A skin biopsy would only be necessary if there were skin lesions indicative of dermatitis herpetiformis. Repeating the IgA-tTG serology test is not recommended for diagnosis.
Investigating Coeliac Disease
Coeliac disease is a condition caused by sensitivity to gluten, which leads to villous atrophy and malabsorption. It is often associated with other conditions such as dermatitis herpetiformis and autoimmune disorders. Diagnosis is made through a combination of serology and endoscopic intestinal biopsy, with villous atrophy and immunology typically reversing on a gluten-free diet.
To investigate coeliac disease, NICE guidelines recommend using tissue transglutaminase (TTG) antibodies (IgA) as the first-choice serology test, along with endomyseal antibody (IgA) and testing for selective IgA deficiency. Anti-gliadin antibody (IgA or IgG) tests are not recommended. The ‘gold standard’ for diagnosis is an endoscopic intestinal biopsy, which should be performed in all suspected cases to confirm or exclude the diagnosis. Findings supportive of coeliac disease include villous atrophy, crypt hyperplasia, increase in intraepithelial lymphocytes, and lamina propria infiltration with lymphocytes. Rectal gluten challenge is a less commonly used method.
In summary, investigating coeliac disease involves a combination of serology and endoscopic intestinal biopsy, with NICE guidelines recommending specific tests and the ‘gold standard’ being an intestinal biopsy. Findings supportive of coeliac disease include villous atrophy, crypt hyperplasia, and lymphocyte infiltration.
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This question is part of the following fields:
- Gastrointestinal System
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Question 62
Correct
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A 20-year-old male is having surgery to remove his appendix due to appendicitis. Where is the appendix typically located in the body?
Your Answer: Retrocaecal
Explanation:The majority of appendixes are located in the retrocaecal position. In cases where removal of a retrocaecal appendix proves challenging, mobilizing the right colon can greatly enhance accessibility.
Appendix Anatomy and Location
The appendix is a small, finger-like projection located at the base of the caecum. It can be up to 10cm long and is mainly composed of lymphoid tissue, which can sometimes lead to confusion with mesenteric adenitis. The caecal taenia coli converge at the base of the appendix, forming a longitudinal muscle cover over it. This convergence can aid in identifying the appendix during surgery, especially if it is retrocaecal and difficult to locate. The arterial supply to the appendix comes from the appendicular artery, which is a branch of the ileocolic artery. It is important to note that the appendix is intra-peritoneal.
McBurney’s Point and Appendix Positions
McBurney’s point is a landmark used to locate the appendix during physical examination. It is located one-third of the way along a line drawn from the Anterior Superior Iliac Spine to the Umbilicus. The appendix can be found in six different positions, with the retrocaecal position being the most common at 74%. Other positions include pelvic, postileal, subcaecal, paracaecal, and preileal. It is important to be aware of these positions as they can affect the presentation of symptoms and the difficulty of locating the appendix during surgery.
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This question is part of the following fields:
- Gastrointestinal System
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Question 63
Correct
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A 32-year-old female undergoes an emergency caesarean section due to failed induction of labor and a macrosomic baby. After delivery, she is transferred to the postnatal ward. However, prior to discharge, she complains of abdominal pain, has a fever of 39ºC, and a tachycardia of 106 bpm. A CT scan reveals the presence of fluid accumulation in the retroperitoneal space. What is the probable cause of these CT findings?
Your Answer: Ureteral injury during caesarean section
Explanation:If the ureters are damaged during a caesarean section, it can cause fluid to accumulate in the retroperitoneal area. This can lead to pain and inflammation, which may present as fever and a rapid heartbeat. Ovarian thrombus is a rare complication that can occur after a caesarean section. CT scans can show filling defects and an increased diameter in the affected vein. The pyloric antrum is located near the bottom of the stomach, close to the pyloric sphincter. Since the stomach is an intraperitoneal organ in the left upper quadrant, it is unlikely to be lacerated during a caesarean section. Any damage to the stomach would not result in retroperitoneal fluid accumulation.
The retroperitoneal structures are those that are located behind the peritoneum, which is the membrane that lines the abdominal cavity. These structures include the duodenum (2nd, 3rd, and 4th parts), ascending and descending colon, kidneys, ureters, aorta, and inferior vena cava. They are situated in the back of the abdominal cavity, close to the spine. In contrast, intraperitoneal structures are those that are located within the peritoneal cavity, such as the stomach, duodenum (1st part), jejunum, ileum, transverse colon, and sigmoid colon. It is important to note that the retroperitoneal structures are not well demonstrated in the diagram as the posterior aspect has been removed, but they are still significant in terms of their location and function.
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This question is part of the following fields:
- Gastrointestinal System
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Question 64
Correct
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A 63-year-old man arrives at the emergency department complaining of dizziness and haematemesis that started 2 hours ago. He has a medical history of hypertension and type 2 diabetes mellitus.
The patient is stabilized after receiving 2 litres of normal saline for fluid resuscitation. The next day, a gastroscopy is performed, revealing a peptic ulcer that is no longer actively bleeding. The CLO test is positive, indicating the presence of the likely organism.
What is the name of the enzyme secreted by this organism to aid its survival in the stomach?Your Answer: Urease
Explanation:Helicobacter pylori uses urease to survive in the stomach by neutralizing gastric acid. This enzyme produces ammonia, which creates a more suitable environment for bacterial growth. The patient’s CLO positive peptic ulcer is consistent with a Helicobacter pylori infection. It is important to note that Helicobacter pylori does not use arginase, beta-lactamase, protease, or trypsin to neutralize stomach acid.
Helicobacter pylori: A Bacteria Associated with Gastrointestinal Problems
Helicobacter pylori is a type of Gram-negative bacteria that is commonly associated with various gastrointestinal problems, particularly peptic ulcer disease. This bacterium has two primary mechanisms that allow it to survive in the acidic environment of the stomach. Firstly, it uses its flagella to move away from low pH areas and burrow into the mucous lining to reach the epithelial cells underneath. Secondly, it secretes urease, which converts urea to NH3, leading to an alkalinization of the acidic environment and increased bacterial survival.
The pathogenesis mechanism of Helicobacter pylori involves the release of bacterial cytotoxins, such as the CagA toxin, which can disrupt the gastric mucosa. This bacterium is associated with several gastrointestinal problems, including peptic ulcer disease, gastric cancer, B cell lymphoma of MALT tissue, and atrophic gastritis. However, its role in gastro-oesophageal reflux disease (GORD) is unclear, and there is currently no role for the eradication of Helicobacter pylori in GORD.
The management of Helicobacter pylori infection involves a 7-day course of treatment with a proton pump inhibitor, amoxicillin, and either clarithromycin or metronidazole. For patients who are allergic to penicillin, a proton pump inhibitor, metronidazole, and clarithromycin are used instead.
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This question is part of the following fields:
- Gastrointestinal System
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Question 65
Correct
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A 72-year-old woman is being evaluated on the ward due to concerns raised by the nursing staff regarding her altered bowel habits. The patient has been experiencing bowel movements approximately 12 times a day for the past two days and is experiencing crampy abdominal pain.
The patient's blood test results are as follows:
- Hemoglobin (Hb) level of 124 g/L (normal range for females: 115-160 g/L)
- Platelet count of 175 * 109/L (normal range: 150-400 * 109/L)
- White blood cell (WBC) count of 16.4 * 109/L (normal range: 4.0-11.0 * 109/L)
Upon reviewing her medication chart, it is noted that she recently finished a course of ceftriaxone for meningitis.
Based on the likely diagnosis, what would be the most probable finding on stool microscopy?Your Answer: Gram-positive bacilli
Explanation:The likely diagnosis for this patient is a Clostridium difficile infection, which is a gram-positive bacillus bacteria. This infection is triggered by recent broad-spectrum antibiotic use, as seen in this patient who was prescribed ceftriaxone for meningitis. The patient’s symptoms of crampy abdominal pain and sudden onset diffuse diarrhoea, along with a marked rise in white blood cells, are consistent with this diagnosis. Gram-negative bacilli, gram-negative cocci, and gram-negative spirillum bacteria are unlikely causes of this patient’s symptoms.
Clostridium difficile is a type of bacteria that is commonly found in hospitals. It produces a toxin that can damage the intestines and cause a condition called pseudomembranous colitis. This bacteria usually develops when the normal gut flora is disrupted by broad-spectrum antibiotics, with second and third generation cephalosporins being the leading cause. Other risk factors include the use of proton pump inhibitors. Symptoms of C. difficile infection include diarrhea, abdominal pain, and a raised white blood cell count. The severity of the infection can be determined using the Public Health England severity scale.
To diagnose C. difficile infection, a stool sample is tested for the presence of the C. difficile toxin. Treatment involves reviewing current antibiotic therapy and stopping antibiotics if possible. For a first episode of infection, oral vancomycin is the first-line therapy for 10 days, followed by oral fidaxomicin as second-line therapy and oral vancomycin with or without IV metronidazole as third-line therapy. Recurrent infections may require different treatment options, such as oral fidaxomicin within 12 weeks of symptom resolution or oral vancomycin or fidaxomicin after 12 weeks of symptom resolution. In life-threatening cases, oral vancomycin and IV metronidazole may be used, and surgery may be considered with specialist advice. Other therapies, such as bezlotoxumab and fecal microbiota transplant, may also be considered for preventing recurrences in certain cases.
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This question is part of the following fields:
- Gastrointestinal System
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Question 66
Correct
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A 58-year-old woman presents to the colorectal clinic with complaints of pruritus ani. During the examination, a polypoidal mass is discovered below the dentate line. A biopsy confirms the presence of squamous cell carcinoma. Which lymph node groups are at risk of metastasis from this lesion?
Your Answer: Inguinal
Explanation:If there are any injuries or abnormalities located beyond the dentate line, they will be drained towards the inguinal nodes. In some cases, this may require a block dissection of the groin.
Anatomy of the Rectum
The rectum is a capacitance organ that measures approximately 12 cm in length. It consists of both intra and extraperitoneal components, with the transition from the sigmoid colon marked by the disappearance of the tenia coli. The extra peritoneal rectum is surrounded by mesorectal fat that contains lymph nodes, which are removed during rectal cancer surgery. The fascial layers that surround the rectum are important clinical landmarks, with the fascia of Denonvilliers located anteriorly and Waldeyers fascia located posteriorly.
In males, the rectum is adjacent to the rectovesical pouch, bladder, prostate, and seminal vesicles, while in females, it is adjacent to the recto-uterine pouch (Douglas), cervix, and vaginal wall. Posteriorly, the rectum is in contact with the sacrum, coccyx, and middle sacral artery, while laterally, it is adjacent to the levator ani and coccygeus muscles.
The superior rectal artery supplies blood to the rectum, while the superior rectal vein drains it. Mesorectal lymph nodes located superior to the dentate line drain into the internal iliac and then para-aortic nodes, while those located inferior to the dentate line drain into the inguinal nodes. Understanding the anatomy of the rectum is crucial for surgical procedures and the diagnosis and treatment of rectal diseases.
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This question is part of the following fields:
- Gastrointestinal System
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Question 67
Correct
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A 50-year-old woman is suspected to have hepatitis B. She presents with jaundice and upper abdominal pain. A liver function test was conducted to assess her liver's synthetic capacity.
Which characteristic will provide the most precise indication of her condition?Your Answer: Prothrombin time
Explanation:Liver enzymes are not reliable indicators of liver function, especially in end-stage cirrhosis. Instead, coagulation and albumin levels are better measures to assess liver function.
Prothrombin time is a useful indicator because it reflects the liver’s ability to produce the necessary coagulation factors for blood clotting. A high PT suggests that the liver is not functioning properly.
C-reactive protein (CRP) is not a specific indicator of liver function as it can be elevated in response to any infection in the body.
Hemoglobin levels are not a reliable indicator of liver function as they can be affected by other factors such as anemia or polycythemia.
Liver function tests are not accurate in assessing synthetic liver function as they only reflect damage to the liver and its surrounding areas. Additionally, some LFTs can be elevated due to other conditions, not just liver disease. For example, elevated GGT levels in an LFT can indicate damage to the bile ducts, which can be caused by a gallstone blocking the duct.
Understanding Acute Liver Failure
Acute liver failure is a condition characterized by the sudden onset of liver dysfunction, which can lead to various complications in the body. The causes of acute liver failure include paracetamol overdose, alcohol, viral hepatitis (usually A or B), and acute fatty liver of pregnancy. The symptoms of acute liver failure include jaundice, raised prothrombin time, hypoalbuminaemia, hepatic encephalopathy, and hepatorenal syndrome. It is important to note that liver function tests may not always accurately reflect the synthetic function of the liver, and it is best to assess the prothrombin time and albumin level to determine the severity of the condition. Understanding acute liver failure is crucial in managing and treating this potentially life-threatening condition.
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This question is part of the following fields:
- Gastrointestinal System
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Question 68
Correct
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A patient arrives at the emergency department with complaints of abdominal pain in the right iliac fossa. Upon palpation, the patient experiences pain in the right iliac fossa when pressure is applied to the left iliac fossa. What is the term used to describe this sign?
Your Answer: Rovsing's sign
Explanation:Rovsing’s sign is a diagnostic indicator of appendicitis, characterized by pain in the right lower abdomen when the left lower abdomen is palpated. The Psoas sign is another indicator of appendicitis, where flexing the right hip causes irritation of the psoas muscle. The Obturator sign is also a sign of appendicitis, where discomfort is felt in the obturator internus muscle when both the hip and knees are flexed to 90 degrees. However, McBurney’s sign, which refers to pain in the right lower abdomen 2/3 of the way from the umbilicus to the right anterior superior iliac spine, is not a reliable indicator of appendicitis.
Acute appendicitis is a common condition that requires surgery and can occur at any age, but is most prevalent in young people aged 10-20 years. The pathogenesis of acute appendicitis involves lymphoid hyperplasia or a faecolith, which leads to obstruction of the appendiceal lumen. This obstruction causes gut organisms to invade the appendix wall, resulting in oedema, ischaemia, and possibly perforation.
The most common symptom of acute appendicitis is abdominal pain, which is typically peri-umbilical and radiates to the right iliac fossa due to localised peritoneal inflammation. Other symptoms include mild pyrexia, anorexia, and nausea. Examination may reveal generalised or localised peritonism, rebound and percussion tenderness, guarding and rigidity, and classical signs such as Rovsing’s sign and psoas sign.
Diagnosis of acute appendicitis is typically based on raised inflammatory markers and compatible history and examination findings. Imaging may be used in certain cases, such as ultrasound in females where pelvic organ pathology is suspected. Management of acute appendicitis involves appendicectomy, which can be performed via an open or laparoscopic approach. Patients with perforated appendicitis require copious abdominal lavage, while those without peritonitis who have an appendix mass should receive broad-spectrum antibiotics and consideration given to performing an interval appendicectomy. Intravenous antibiotics alone have been trialled as a treatment for appendicitis, but evidence suggests that this is associated with a longer hospital stay and up to 20% of patients go on to have an appendicectomy within 12 months.
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This question is part of the following fields:
- Gastrointestinal System
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Question 69
Correct
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A 47-year-old woman presents to the out of hours GP service with abdominal pain. She has suffered from 'heartburn' for many years but for the last 6 months she has started getting a different kind of pain, which she describes as 'stabbing'. When asked where she feels it, the patient points to below her right breast. The pain has been occurring more frequently and with greater severity over the last 3 weeks, and tonight it is unbearable. It tends to come on shortly after she has eaten, and lasts up to 3 hours. She denies constipation, diarrhoea and vomiting, although she feels nauseated. She reports 'a couple of pounds' weight loss over the last few weeks because she has been eating less to avoid the pain.
On examination her abdomen is soft but very tender in the right upper quadrant, with a positive Murphy's sign. She is afebrile and normotensive.
What is the most likely cause of the patient's presentation?Your Answer: Biliary colic
Explanation:Biliary colic can be characterized by pain that occurs after eating, especially after consuming high-fat meals. The patient’s symptoms are consistent with this type of pain. However, if the patient were experiencing ascending cholangitis, they would likely be more acutely ill and have a fever. Duodenal ulcers can also cause upper abdominal pain, but the pain tends to be constant, gnawing, and centralized, and may differ with eating. If the ulcer bleeds, the patient may experience haematemesis or melaena. Although the patient reports experiencing heartburn, their current presentation is more indicative of biliary colic than gastro-oesophageal reflux disease.
Understanding Biliary Colic and Gallstone-Related Disease
Biliary colic is a condition that occurs when gallstones pass through the biliary tree. It is more common in women, especially those who are obese, fertile, or over the age of 40. Other risk factors include diabetes, Crohn’s disease, rapid weight loss, and certain medications. Biliary colic is caused by an increase in cholesterol, a decrease in bile salts, and biliary stasis. The pain is due to the gallbladder contracting against a stone lodged in the cystic duct. Symptoms include colicky right upper quadrant abdominal pain, nausea, and vomiting. Unlike other gallstone-related conditions, there is no fever or abnormal liver function tests.
Ultrasound is the preferred diagnostic tool for biliary colic. Elective laparoscopic cholecystectomy is the recommended treatment. However, around 15% of patients may have gallstones in the common bile duct at the time of surgery, which can lead to obstructive jaundice. Other complications of gallstone-related disease include acute cholecystitis, ascending cholangitis, acute pancreatitis, gallstone ileus, and gallbladder cancer. It is important to understand the risk factors, pathophysiology, and management of biliary colic and gallstone-related disease to ensure prompt diagnosis and appropriate treatment.
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This question is part of the following fields:
- Gastrointestinal System
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Question 70
Correct
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Secretions from which of the following will contain the highest levels of potassium?
Your Answer: Rectum
Explanation:The rectum can produce potassium-rich secretions, which is why resins are given to treat hyperkalemia and why patients with villous adenoma of the rectum may experience hypokalemia.
Potassium Secretions in the GI Tract
Potassium is secreted in various parts of the gastrointestinal (GI) tract. The salivary glands can secrete up to 60mmol/L of potassium, while the stomach secretes only 10 mmol/L. The bile, pancreas, and small bowel also secrete potassium, with average figures of 5 mmol/L, 4-5 mmol/L, and 10 mmol/L, respectively. The rectum has the highest potassium secretion, with an average of 30 mmol/L. However, the exact composition of potassium secretions varies depending on factors such as disease, serum aldosterone levels, and serum pH.
It is important to note that gastric potassium secretions are low, and hypokalaemia (low potassium levels) may occur in vomiting. However, this is usually due to renal wasting of potassium rather than potassium loss in vomit. Understanding the different levels of potassium secretion in the GI tract can be helpful in diagnosing and treating potassium-related disorders.
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This question is part of the following fields:
- Gastrointestinal System
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Question 71
Correct
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The antenatal ultrasound (US) performed on a baby small for gestational age, reveals a midline abdominal wall defect with a membranous sac enclosing the protruding intestinal contents. Is it advantageous to offer amniocentesis for additional genetic investigations, despite the potential risks involved?
Your Answer: Early diagnosis of any genetic conditions associated with this defect
Explanation:BWS can also cause gigantism, which may explain the macrosomia observed in this case. Genetic and chromosomal abnormalities are commonly associated with omphalocoele, and genetic studies are conducted to detect any such abnormalities early on, not just Down’s syndrome.
The US findings indicate the presence of an omphalocoele, not a gastroschisis, which is an abdominal wall defect without a membranous sac covering, usually located to the right of a normal umbilical cord insertion site. As such, genetic studies are not used to diagnose either defect, and this option is incorrect.
Omphalocoele can be diagnosed without genetic studies, but if the membranous sac ruptures in utero, there may be some uncertainty in the diagnosis. In such cases, genetic studies can help confirm the diagnosis, given the high incidence of associated genetic abnormalities with omphalocoele.
While foetuses with omphalocoele are more likely to have associated structural defects, genetic studies are not useful in identifying these. An echocardiogram would be a more effective means of detecting any other structural defects.
Gastroschisis and Exomphalos: Congenital Visceral Malformations
Gastroschisis and exomphalos are both types of congenital visceral malformations. Gastroschisis is a condition where there is a defect in the anterior abdominal wall, located just beside the umbilical cord. On the other hand, exomphalos, also known as omphalocoele, is a condition where the abdominal contents protrude through the anterior abdominal wall, but are covered by an amniotic sac formed by amniotic membrane and peritoneum.
In terms of management, vaginal delivery may be attempted for gastroschisis, and newborns should be taken to the operating room as soon as possible after delivery, ideally within four hours. For exomphalos, a caesarean section is indicated to reduce the risk of sac rupture. A staged repair may be undertaken as primary closure may be difficult due to lack of space or high intra-abdominal pressure. If this occurs, the sac is allowed to granulate and epithelialize over the coming weeks or months, forming a shell. As the infant grows, a point will be reached when the sac contents can fit within the abdominal cavity. At this point, the shell will be removed, and the abdomen closed.
Overall, both gastroschisis and exomphalos require careful management and monitoring to ensure the best possible outcomes for the newborn.
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This question is part of the following fields:
- Gastrointestinal System
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Question 72
Correct
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A 68-year-old male presents with sudden and severe abdominal pain. He has a medical history of ischaemic heart disease and takes nitrates, atenolol and amlodipine for it. Upon examination, his pulse is irregularly irregular and measures 115 bpm, his blood pressure is 104/72 mmHg, and his temperature is 37.4°C. The abdomen is diffusely tender and bowel sounds are absent. What is the probable diagnosis?
Your Answer: Mesenteric ischaemia
Explanation:Narrowing Down the Differential Diagnosis for Acute Abdomen
When presented with a patient experiencing an acute abdomen, the differential diagnosis can be extensive. However, by taking note of the key points in the patient’s history and conducting a thorough examination, one can narrow down the potential causes. In the case of a man with absent bowel sounds, atrial fibrillation, and a history of ischemic heart disease, the most likely cause of his presentation is mesenteric ischemia. This is due to the fact that he is not obstructed and has vascular disease. For further information on acute mesenteric ischemia, Medscape provides a helpful resource. By utilizing these tools and resources, healthcare professionals can more accurately diagnose and treat patients with acute abdominal symptoms.
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This question is part of the following fields:
- Gastrointestinal System
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Question 73
Correct
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A 25-year-old female presents to her GP with a 3-month history of bloating. She has tried excluding nightshades from her diet which provided some relief but her symptoms persist. Upon further questioning, she reports a lifelong feeling of incomplete bowel emptying after defecation. This symptom was previously investigated with endoscopy and biopsies, but no definitive diagnosis was made.
Additionally, she reports the presence of mucus in her stool and intermittent abdominal pain. She has no significant medical history or regular medications, but does have a peanut allergy. Her mother has coeliac disease and her father has type 2 diabetes which is managed with insulin.
What is the most likely diagnosis for this patient?Your Answer: Irritable bowel syndrome
Explanation:Diagnosis and Management of Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that affects many people. To diagnose IBS, a patient must have experienced abdominal pain, bloating, or a change in bowel habit for at least six months. A positive diagnosis of IBS is made if the patient has abdominal pain relieved by defecation or associated with altered bowel frequency stool form, in addition to two of the following four symptoms: altered stool passage, abdominal bloating, symptoms made worse by eating, and passage of mucus. Other features such as lethargy, nausea, backache, and bladder symptoms may also support the diagnosis.
It is important to enquire about red flag features such as rectal bleeding, unexplained/unintentional weight loss, family history of bowel or ovarian cancer, and onset after 60 years of age. Primary care investigations such as a full blood count, ESR/CRP, and coeliac disease screen (tissue transglutaminase antibodies) are suggested. The National Institute for Health and Care Excellence (NICE) published clinical guidelines on the diagnosis and management of IBS in 2008 to help healthcare professionals provide the best care for patients with this condition.
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This question is part of the following fields:
- Gastrointestinal System
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Question 74
Correct
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At which of the following sites is the development of diverticulosis least likely in individuals over 60 years of age?
Your Answer: Rectum
Explanation:It is extremely rare for diverticular disease to affect the rectum due to the circular muscle coat present in this area, which is a result of the blending of the tenia at the recto-sigmoid junction. While left-sided colonic diverticular disease is more common, right-sided colonic diverticular disease is also acknowledged.
Understanding Diverticular Disease
Diverticular disease is a common condition that involves the protrusion of the colon’s mucosa through its muscular wall. This typically occurs between the taenia coli, where vessels penetrate the muscle to supply the mucosa. Symptoms of diverticular disease include altered bowel habits, rectal bleeding, and abdominal pain. Complications can arise, such as diverticulitis, haemorrhage, fistula development, perforation and faecal peritonitis, abscess formation, and diverticular phlegmon.
To diagnose diverticular disease, patients may undergo a colonoscopy, CT cologram, or barium enema. However, it can be challenging to rule out cancer, especially in diverticular strictures. Acutely unwell surgical patients require a systematic investigation, including plain abdominal films and an erect chest x-ray to identify perforation. An abdominal CT scan with oral and intravenous contrast can help identify acute inflammation and local complications.
Treatment for diverticular disease includes increasing dietary fibre intake and managing mild attacks with antibiotics. Peri colonic abscesses require drainage, either surgically or radiologically. Recurrent episodes of acute diverticulitis requiring hospitalisation may indicate a segmental resection. Hinchey IV perforations, which involve generalised faecal peritonitis, require a resection and usually a stoma. This group has a high risk of postoperative complications and typically requires HDU admission. Less severe perforations may be managed by laparoscopic washout and drain insertion.
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This question is part of the following fields:
- Gastrointestinal System
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Question 75
Correct
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A 54-year-old male presents to the emergency department with frank haematemesis. He is urgently resuscitated and undergoes an urgent oesophagogastroduodenoscopy (OGD), which reveals an active bleed in the distal part of the lesser curvature of the stomach. The bleed is successfully controlled with endoclips and adrenaline. The patient has a history of gastric ulcers. What is the most probable artery responsible for the bleeding?
Your Answer: Right gastric artery
Explanation:The distal lesser curvature of the stomach is supplied by the right gastric artery, while the proximal lesser curvature is supplied by the left gastric artery. The proximal greater curvature is supplied by the left gastroepiploic artery, and the distal greater curvature is supplied by the right gastroepiploic artery.
The Gastroduodenal Artery: Supply and Path
The gastroduodenal artery is responsible for supplying blood to the pylorus, proximal part of the duodenum, and indirectly to the pancreatic head through the anterior and posterior superior pancreaticoduodenal arteries. It commonly arises from the common hepatic artery of the coeliac trunk and terminates by bifurcating into the right gastroepiploic artery and the superior pancreaticoduodenal artery.
To better understand the relationship of the gastroduodenal artery to the first part of the duodenum, the stomach is reflected superiorly in an image sourced from Wikipedia. This artery plays a crucial role in providing oxygenated blood to the digestive system, ensuring proper functioning and health.
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This question is part of the following fields:
- Gastrointestinal System
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Question 76
Correct
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A 65-year-old woman presents with microcytic anaemia on routine blood tests. She reports feeling fatigued and experiencing occasional episodes of fresh red blood in her stool. Despite passing stool less frequently, she expresses no concern to her physician. What is the probable diagnosis?
Your Answer: Rectal cancer
Explanation:Rectal cancer is characterized by symptoms such as passing fresh blood, which distinguishes it from duodenal cancer that presents with upper gastrointestinal bleeding. Inflammatory bowel disease typically includes abdominal pain, fever, and passing bloody stools, and may have more severe presentations, but microcytic anemia is not a common feature. Irritable bowel syndrome does not involve passing bloody stools and is associated with vague symptoms like bloating, backache, and urinary problems. Gastroenteritis is unlikely as it is accompanied by vomiting, diarrhea, and fever, which the patient has not reported.
Colorectal cancer is a prevalent type of cancer in the UK, ranking third in terms of frequency and second in terms of cancer-related deaths. Every year, approximately 150,000 new cases are diagnosed, and 50,000 people die from the disease. The cancer can occur in different parts of the colon, with the rectum being the most common location, accounting for 40% of cases. The sigmoid colon follows closely, with 30% of cases, while the descending colon has only 5%. The transverse colon has 10% of cases, and the ascending colon and caecum have 15%.
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This question is part of the following fields:
- Gastrointestinal System
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Question 77
Correct
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A 47-year-old man has a nasogastric tube inserted. The nurse takes a small aspirate of the fluid from the stomach and tests the pH of the aspirate. What is the typical intragastric pH?
Your Answer: 2
Explanation:Typically, the pH level in the stomach is 2, but the use of proton pump inhibitors can effectively eliminate acidity.
Understanding Gastric Secretions for Surgical Procedures
A basic understanding of gastric secretions is crucial for surgeons, especially when dealing with patients who have undergone acid-lowering procedures or are prescribed anti-secretory drugs. Gastric acid, produced by the parietal cells in the stomach, has a pH of around 2 and is maintained by the H+/K+ ATPase pump. Sodium and chloride ions are actively secreted from the parietal cell into the canaliculus, creating a negative potential across the membrane. Carbonic anhydrase forms carbonic acid, which dissociates, and the hydrogen ions formed by dissociation leave the cell via the H+/K+ antiporter pump. This leaves hydrogen and chloride ions in the canaliculus, which mix and are secreted into the lumen of the oxyntic gland.
There are three phases of gastric secretion: the cephalic phase, gastric phase, and intestinal phase. The cephalic phase is stimulated by the smell or taste of food and causes 30% of acid production. The gastric phase, which is caused by stomach distension, low H+, or peptides, causes 60% of acid production. The intestinal phase, which is caused by high acidity, distension, or hypertonic solutions in the duodenum, inhibits gastric acid secretion via enterogastrones and neural reflexes.
The regulation of gastric acid production involves various factors that increase or decrease production. Factors that increase production include vagal nerve stimulation, gastrin release, and histamine release. Factors that decrease production include somatostatin, cholecystokinin, and secretin. Understanding these factors and their associated pharmacology is essential for surgeons.
In summary, a working knowledge of gastric secretions is crucial for surgical procedures, especially when dealing with patients who have undergone acid-lowering procedures or are prescribed anti-secretory drugs. Understanding the phases of gastric secretion and the regulation of gastric acid production is essential for successful surgical outcomes.
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This question is part of the following fields:
- Gastrointestinal System
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Question 78
Incorrect
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A 55-year-old man presents with odynophagia and undergoes an upper GI endoscopy. During the procedure, a reddish area is observed protruding into the esophagus from the gastroesophageal junction. What is the most probable pathological cause for this phenomenon?
Your Answer: Dysplasia
Correct Answer: Metaplasia
Explanation:Metaplasia is the most probable diagnosis for this condition, indicating Barretts oesophagus. However, biopsies are necessary to rule out dysplasia.
Barrett’s oesophagus is a condition where the lower oesophageal mucosa is replaced by columnar epithelium, which increases the risk of oesophageal adenocarcinoma by 50-100 fold. It is usually identified during an endoscopy for upper gastrointestinal symptoms such as dyspepsia, as there are no screening programs for it. The length of the affected segment determines the chances of identifying metaplasia, with short (<3 cm) and long (>3 cm) subtypes. The prevalence of Barrett’s oesophagus is estimated to be around 1 in 20, and it is identified in up to 12% of those undergoing endoscopy for reflux.
The columnar epithelium in Barrett’s oesophagus may resemble that of the cardiac region of the stomach or that of the small intestine, with goblet cells and brush border. The single strongest risk factor for Barrett’s oesophagus is gastro-oesophageal reflux disease (GORD), followed by male gender, smoking, and central obesity. Alcohol is not an independent risk factor for Barrett’s, but it is associated with both GORD and oesophageal cancer. Patients with Barrett’s oesophagus often have coexistent GORD symptoms.
The management of Barrett’s oesophagus involves high-dose proton pump inhibitor, although the evidence base for its effectiveness in reducing the progression to dysplasia or inducing regression of the lesion is limited. Endoscopic surveillance with biopsies is recommended every 3-5 years for patients with metaplasia but not dysplasia. If dysplasia of any grade is identified, endoscopic intervention is offered, such as radiofrequency ablation, which is the preferred first-line treatment, particularly for low-grade dysplasia, or endoscopic mucosal resection.
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This question is part of the following fields:
- Gastrointestinal System
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Question 79
Correct
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A 45-year-old taxi driver presents with a six-month history of constipation and colicky suprapubic pain that varies in intensity without any apparent pattern. He has experienced occasional episodes of diarrhoea and fever. Although he drinks little alcohol and does not smoke, he consumes large amounts of coffee. On examination, there is mild tenderness in the suprapubic region, but no other abnormalities are detected. What is the probable diagnosis?
Your Answer: Diverticular disease
Explanation:Differential Diagnosis for Rectal Bleeding
Rectal bleeding can be a concerning symptom for patients and healthcare providers alike. While neoplasia may be a possible cause, diverticular disease is more common. To confirm the presence of diverticula, a barium enema should be performed, and a sigmoidoscopy should be done to rule out a tumor. Cystitis is rare in men and would present with symptoms such as urinary frequency, urgency, nocturia, and dysuria. Inflammatory bowel disease can affect any part of the gastrointestinal tract and often presents with weight loss, fever, malaise, and potentially arthralgia. However, the lack of systemic symptoms suggests an alternative diagnosis. Ulcerative colitis often causes rectal bleeding, while Crohn’s disease can cause rectal bleeding and inflammation from the mouth to anus. It is more commonly diagnosed in patients before the age of 30. It is important to consider these differential diagnoses when evaluating a patient with rectal bleeding to ensure appropriate management and treatment.
Further Reading:
Janes SE, Meagher A, Frizelle FA. Management of diverticulitis. BMJ. 2006;332:271-5. -
This question is part of the following fields:
- Gastrointestinal System
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Question 80
Correct
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A 14-year-old girl presents with pyelonephritis and septic shock. What is an atypical finding in this condition?
Your Answer: Increased systemic vascular resistance
Explanation:Cardiogenic shock, which can be caused by conditions such as a heart attack or valve abnormality, results in decreased cardiac output and blood pressure, as well as increased systemic vascular resistance (SVR) and heart rate due to a sympathetic response.
Hypovolemic shock, on the other hand, occurs when there is a depletion of blood volume due to factors such as bleeding, vomiting, diarrhea, dehydration, or third-space losses during surgery. This also leads to increased SVR and heart rate, as well as decreased cardiac output and blood pressure.
Septic shock, which can also occur in response to anaphylaxis or neurogenic shock, is characterized by reduced SVR and increased heart rate, but normal or increased cardiac output. In this case, a vasopressor like noradrenaline may be used to address hypotension and oliguria despite adequate fluid administration.
Shock is a condition where there is not enough blood flow to the tissues. There are five main types of shock: septic, haemorrhagic, neurogenic, cardiogenic, and anaphylactic. Septic shock is caused by an infection that triggers a particular response in the body. Haemorrhagic shock is caused by blood loss, and there are four classes of haemorrhagic shock based on the amount of blood loss and associated symptoms. Neurogenic shock occurs when there is a disruption in the autonomic nervous system, leading to decreased vascular resistance and decreased cardiac output. Cardiogenic shock is caused by heart disease or direct myocardial trauma. Anaphylactic shock is a severe, life-threatening allergic reaction. Adrenaline is the most important drug in treating anaphylaxis and should be given as soon as possible.
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This question is part of the following fields:
- Gastrointestinal System
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Question 81
Correct
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A 65-year-old patient loses 1.6L of fresh blood from their abdominal drain. Which of the following will not decrease?
Your Answer: Renin secretion
Explanation:Renin secretion is likely to increase when there is systemic hypotension leading to a decrease in renal blood flow. While the kidney can regulate its own blood flow within a certain range of systemic blood pressures, a reduction of 1.6 L typically results in an elevation of renin secretion.
Shock is a condition where there is not enough blood flow to the tissues. There are five main types of shock: septic, haemorrhagic, neurogenic, cardiogenic, and anaphylactic. Septic shock is caused by an infection that triggers a particular response in the body. Haemorrhagic shock is caused by blood loss, and there are four classes of haemorrhagic shock based on the amount of blood loss and associated symptoms. Neurogenic shock occurs when there is a disruption in the autonomic nervous system, leading to decreased vascular resistance and decreased cardiac output. Cardiogenic shock is caused by heart disease or direct myocardial trauma. Anaphylactic shock is a severe, life-threatening allergic reaction. Adrenaline is the most important drug in treating anaphylaxis and should be given as soon as possible.
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This question is part of the following fields:
- Gastrointestinal System
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Question 82
Correct
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How many unpaired branches does the abdominal aorta have to provide blood supply to the abdominal organs?
Your Answer: Three
Explanation:The abdominal viscera has three branches that are not paired, namely the coeliac axis, the SMA, and the IMA. Meanwhile, the branches to the adrenals, renal arteries, and gonadal vessels are paired. It is worth noting that the fourth unpaired branch of the abdominal aorta, which is the median sacral artery, does not provide direct supply to the abdominal viscera.
Branches of the Abdominal Aorta
The abdominal aorta is a major blood vessel that supplies oxygenated blood to the abdominal organs and lower extremities. It gives rise to several branches that supply blood to various organs and tissues. These branches can be classified into two types: parietal and visceral.
The parietal branches supply blood to the walls of the abdominal cavity, while the visceral branches supply blood to the abdominal organs. The branches of the abdominal aorta include the inferior phrenic, coeliac, superior mesenteric, middle suprarenal, renal, gonadal, lumbar, inferior mesenteric, median sacral, and common iliac arteries.
The inferior phrenic artery arises from the upper border of the abdominal aorta and supplies blood to the diaphragm. The coeliac artery supplies blood to the liver, stomach, spleen, and pancreas. The superior mesenteric artery supplies blood to the small intestine, cecum, and ascending colon. The middle suprarenal artery supplies blood to the adrenal gland. The renal arteries supply blood to the kidneys. The gonadal arteries supply blood to the testes or ovaries. The lumbar arteries supply blood to the muscles and skin of the back. The inferior mesenteric artery supplies blood to the descending colon, sigmoid colon, and rectum. The median sacral artery supplies blood to the sacrum and coccyx. The common iliac arteries are the terminal branches of the abdominal aorta and supply blood to the pelvis and lower extremities.
Understanding the branches of the abdominal aorta is important for diagnosing and treating various medical conditions that affect the abdominal organs and lower extremities.
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This question is part of the following fields:
- Gastrointestinal System
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Question 83
Correct
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Is the presence of liver metastases necessary for the development of carcinoid syndrome?
The following are true of carcinoid tumours except:
- When present in the appendix tip and measure less than 2 cm have an excellent prognosis (33%)
- Even when metastatic disease is present it tends to follow a protracted course (26%)
- When present in the appendix body tend to present with carcinoid syndrome even when liver metastases are not present (17%)
- May be imaged using 5 HIAA radionucleotide scanning (12%)
- Advanced appendiceal carcinoids may require right hemicolectomy (12%)
Rule of thirds:
- 1/3 multiple
- 1/3 small bowel
- 1/3 metastasize
- 1/3 second tumour
Important for me:
Less important:Your Answer: When present in the appendix body tend to present with carcinoid syndrome even when liver metastases are not present
Explanation:The presence of liver metastases is a requirement for the occurrence of carcinoid syndrome. The liver is divided into thirds, with one-third dedicated to multiple tumors, one-third to small bowel involvement, and one-third to metastasis or the development of a secondary tumor.
Carcinoid tumours are a type of cancer that can cause a condition called carcinoid syndrome. This syndrome typically occurs when the cancer has spread to the liver and releases serotonin into the bloodstream. In some cases, it can also occur with lung carcinoid tumours, as the mediators are not cleared by the liver. The earliest symptom of carcinoid syndrome is often flushing, but it can also cause diarrhoea, bronchospasm, hypotension, and right heart valvular stenosis (or left heart involvement in bronchial carcinoid). Additionally, other molecules such as ACTH and GHRH may be secreted, leading to conditions like Cushing’s syndrome. Pellagra, a rare condition caused by a deficiency in niacin, can also develop as the tumour diverts dietary tryptophan to serotonin.
To investigate carcinoid syndrome, doctors may perform a urinary 5-HIAA test or a plasma chromogranin A test. Treatment for the condition typically involves somatostatin analogues like octreotide, which can help manage symptoms like diarrhoea. Cyproheptadine may also be used to alleviate diarrhoea. Overall, early detection and treatment of carcinoid tumours can help prevent the development of carcinoid syndrome and improve outcomes for patients.
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This question is part of the following fields:
- Gastrointestinal System
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Question 84
Correct
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Lila, a 7-year-old girl, undergoes surgery to correct an inguinal hernia. During the operation, how can the surgeon confirm that Lila has an indirect hernia?
Your Answer: Indirect hernia is lateral to the epigastric vessels
Explanation:An indirect inguinal hernia is situated on the lateral side of the epigastric vessels. This type of hernia occurs when the processus vaginalis fails to close properly, causing a protrusion through the deep inguinal ring and into the inguinal canal. In males, the hernia may extend into the scrotum, while in females, it may extend into the labia. On the other hand, a direct inguinal hernia is caused by weakened abdominal muscles, typically occurring in older individuals. The protrusion enters the inguinal canal through the posterior wall, which is located on the medial side of the epigastric vessels. It may then exit through the superficial inguinal ring.
Understanding Inguinal Hernias
Inguinal hernias are the most common type of abdominal wall hernias, with 75% of cases falling under this category. They are more prevalent in men, with a 25% lifetime risk of developing one. The main symptom is a lump in the groin area, which disappears when pressure is applied or when the patient lies down. Discomfort and aching are also common, especially during physical activity. However, severe pain is rare, and strangulation is even rarer.
The traditional classification of inguinal hernias into indirect and direct types is no longer relevant in clinical management. Instead, the current consensus is to treat medically fit patients, even if they are asymptomatic. A hernia truss may be an option for those who are not fit for surgery, but it has limited use in other patients. Mesh repair is the preferred method, as it has the lowest recurrence rate. Unilateral hernias are usually repaired through an open approach, while bilateral and recurrent hernias are repaired laparoscopically.
After surgery, patients are advised to return to non-manual work after 2-3 weeks for open repair and 1-2 weeks for laparoscopic repair. Complications may include early bruising and wound infection, as well as late chronic pain and recurrence. It is important to seek medical attention if any of these symptoms occur.
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This question is part of the following fields:
- Gastrointestinal System
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Question 85
Correct
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An 80-year-old man visits his GP complaining of indigestion that has persisted for the last three months. He has a medical history of hypertension and is a heavy smoker with a 50-pack-year history. He also consumes three glasses of wine on weeknights. Upon referral to a gastroenterologist, a lower oesophageal and stomach biopsy is performed, revealing metaplastic columnar epithelium. What is the primary factor that has contributed to the development of this histological finding?
Your Answer: Gastro-oesophageal reflux disease (GORD)
Explanation:Barrett’s oesophagus is diagnosed in this patient based on the presence of metaplastic columnar epithelium in the oesophageal epithelium. The most significant risk factor for the development of Barrett’s oesophagus is gastro-oesophageal reflux disease (GORD). While age is also a risk factor, it is not as strong as GORD. Alcohol consumption is not associated with Barrett’s oesophagus, but it is a risk factor for squamous cell oesophageal carcinoma. Infection with Helicobacter pylori is not linked to Barrett’s oesophagus, and it may even reduce the risk of GORD and Barrett’s oesophagus. Smoking is associated with both GORD and Barrett’s oesophagus, but the strength of this association is not as significant as that of GORD.
Barrett’s oesophagus is a condition where the lower oesophageal mucosa is replaced by columnar epithelium, which increases the risk of oesophageal adenocarcinoma by 50-100 fold. It is usually identified during an endoscopy for upper gastrointestinal symptoms such as dyspepsia, as there are no screening programs for it. The length of the affected segment determines the chances of identifying metaplasia, with short (<3 cm) and long (>3 cm) subtypes. The prevalence of Barrett’s oesophagus is estimated to be around 1 in 20, and it is identified in up to 12% of those undergoing endoscopy for reflux.
The columnar epithelium in Barrett’s oesophagus may resemble that of the cardiac region of the stomach or that of the small intestine, with goblet cells and brush border. The single strongest risk factor for Barrett’s oesophagus is gastro-oesophageal reflux disease (GORD), followed by male gender, smoking, and central obesity. Alcohol is not an independent risk factor for Barrett’s, but it is associated with both GORD and oesophageal cancer. Patients with Barrett’s oesophagus often have coexistent GORD symptoms.
The management of Barrett’s oesophagus involves high-dose proton pump inhibitor, although the evidence base for its effectiveness in reducing the progression to dysplasia or inducing regression of the lesion is limited. Endoscopic surveillance with biopsies is recommended every 3-5 years for patients with metaplasia but not dysplasia. If dysplasia of any grade is identified, endoscopic intervention is offered, such as radiofrequency ablation, which is the preferred first-line treatment, particularly for low-grade dysplasia, or endoscopic mucosal resection.
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This question is part of the following fields:
- Gastrointestinal System
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Question 86
Correct
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A 75-year-old man is scheduled for a sub total oesophagectomy with anastomosis of the stomach to the cervical oesophagus. What is the primary vessel responsible for supplying arterial blood to the oesophageal portion of the anastomosis?
Your Answer: Inferior thyroid artery
Explanation:The inferior thyroid artery supplies the cervical oesophagus, while direct branches from the thoracic aorta supply the thoracic oesophagus (which has been removed in this case).
Anatomy of the Oesophagus
The oesophagus is a muscular tube that is approximately 25 cm long and starts at the C6 vertebrae, pierces the diaphragm at T10, and ends at T11. It is lined with non-keratinized stratified squamous epithelium and has constrictions at various distances from the incisors, including the cricoid cartilage at 15cm, the arch of the aorta at 22.5cm, the left principal bronchus at 27cm, and the diaphragmatic hiatus at 40cm.
The oesophagus is surrounded by various structures, including the trachea to T4, the recurrent laryngeal nerve, the left bronchus and left atrium, and the diaphragm anteriorly. Posteriorly, it is related to the thoracic duct to the left at T5, the hemiazygos to the left at T8, the descending aorta, and the first two intercostal branches of the aorta. The arterial, venous, and lymphatic drainage of the oesophagus varies depending on the location, with the upper third being supplied by the inferior thyroid artery and drained by the deep cervical lymphatics, the mid-third being supplied by aortic branches and drained by azygos branches and mediastinal lymphatics, and the lower third being supplied by the left gastric artery and drained by posterior mediastinal and coeliac veins and gastric lymphatics.
The nerve supply of the oesophagus also varies, with the upper half being supplied by the recurrent laryngeal nerve and the lower half being supplied by the oesophageal plexus of the vagus nerve. The muscularis externa of the oesophagus is composed of both smooth and striated muscle, with the composition varying depending on the location.
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This question is part of the following fields:
- Gastrointestinal System
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Question 87
Correct
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A 67-year-old man has been admitted to the surgical ward with abdominal pain and rectal bleeding. According to the notes, he has not had a bowel movement in five days. Additionally, he has begun vomiting and his abdomen is swollen.
What is the probable diagnosis?Your Answer: Large bowel obstruction
Explanation:Large bowel obstruction is the most likely diagnosis based on the pattern of symptoms, which include abdominal distension, absence of passing flatus or stool, and late onset or no vomiting.
Large bowel obstruction occurs when there is a blockage in the passage of food, fluids, and gas through the large intestines. The most common cause of this condition is a tumor, accounting for 60% of cases. Colonic malignancy is often the initial presenting complaint in approximately 30% of cases, especially in more distal colonic and rectal tumors due to their smaller lumen diameter. Other causes include volvulus and diverticular disease.
Clinical features of large bowel obstruction include abdominal pain, distention, and absence of passing flatus or stool. Nausea and vomiting may suggest a more proximal lesion, while peritonism may be present if there is associated bowel perforation. It is important to consider the underlying causes, such as recent symptoms suggestive of colorectal cancer.
Abdominal x-ray is still commonly used as a first-line investigation, with a diameter greater than the normal limits of 10-12 cm for the caecum, 8 cm for the ascending colon, and 6.5 cm for recto-sigmoid being diagnostic of obstruction. CT scan is highly sensitive and specific for identifying obstruction and its underlying cause.
Initial management of large bowel obstruction includes NBM, IV fluids, and nasogastric tube with free drainage. Conservative management for up to 72 hours can be trialed if the cause of obstruction does not require surgery, after which further management may be required if there is no resolution. Around 75% of cases will eventually require surgery. IV antibiotics are given if perforation is suspected or surgery is planned. Emergency surgery is necessary if there is any overt peritonitis or evidence of bowel perforation, involving irrigation of the abdominal cavity, resection of perforated segment and ischaemic bowel, and addressing the underlying cause of the obstruction.
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This question is part of the following fields:
- Gastrointestinal System
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Question 88
Correct
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The action of which one of the following brush border enzymes leads to the production of glucose and galactose?
Your Answer: Lactase
Explanation:Enzymes play a crucial role in the breakdown of carbohydrates in the gastrointestinal system. Amylase, which is present in both saliva and pancreatic secretions, is responsible for breaking down starch into sugar. On the other hand, brush border enzymes such as maltase, sucrase, and lactase are involved in the breakdown of specific disaccharides. Maltase cleaves maltose into glucose and glucose, sucrase cleaves sucrose into fructose and glucose, while lactase cleaves lactose into glucose and galactose. These enzymes work together to ensure that carbohydrates are broken down into their simplest form for absorption into the bloodstream.
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This question is part of the following fields:
- Gastrointestinal System
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Question 89
Correct
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A 36-year-old female patient presents with persistent dyspepsia of 6 months duration. She failed multiple trials of conservative treatment by her GP, therefore, she was referred for the gastroenterologist for further review.
Investigations were done and her urea breath test was negative for Helicobacter pylori. Gastroscopy revealed multiple gastroduodenal ulcers. What type of cells are affected by the high levels of fasting gastrin detected?Your Answer: Gastric parietal cells
Explanation:The secretion of gastrin hormone from G cells in the antrum of the stomach is responsible for increasing the secretion of H+ by gastric parietal cells. Additionally, chief cells secrete pepsin, which is a proteolytic enzyme, while D cells in the pancreas and stomach secrete somatostatin hormone. Gastrin hormone is released in response to distension of the stomach and vagal stimulation.
Overview of Gastrointestinal Hormones
Gastrointestinal hormones play a crucial role in the digestion and absorption of food. These hormones are secreted by various cells in the stomach and small intestine in response to different stimuli such as the presence of food, pH changes, and neural signals.
One of the major hormones involved in food digestion is gastrin, which is secreted by G cells in the antrum of the stomach. Gastrin increases acid secretion by gastric parietal cells, stimulates the secretion of pepsinogen and intrinsic factor, and increases gastric motility. Another hormone, cholecystokinin (CCK), is secreted by I cells in the upper small intestine in response to partially digested proteins and triglycerides. CCK increases the secretion of enzyme-rich fluid from the pancreas, contraction of the gallbladder, and relaxation of the sphincter of Oddi. It also decreases gastric emptying and induces satiety.
Secretin is another hormone secreted by S cells in the upper small intestine in response to acidic chyme and fatty acids. Secretin increases the secretion of bicarbonate-rich fluid from the pancreas and hepatic duct cells, decreases gastric acid secretion, and has a trophic effect on pancreatic acinar cells. Vasoactive intestinal peptide (VIP) is a neural hormone that stimulates secretion by the pancreas and intestines and inhibits acid secretion.
Finally, somatostatin is secreted by D cells in the pancreas and stomach in response to fat, bile salts, and glucose in the intestinal lumen. Somatostatin decreases acid and pepsin secretion, decreases gastrin secretion, decreases pancreatic enzyme secretion, and decreases insulin and glucagon secretion. It also inhibits the trophic effects of gastrin and stimulates gastric mucous production.
In summary, gastrointestinal hormones play a crucial role in regulating the digestive process and maintaining homeostasis in the gastrointestinal tract.
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This question is part of the following fields:
- Gastrointestinal System
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Question 90
Correct
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A 50-year-old woman arrives at the emergency department complaining of abrupt abdominal pain. She has a 35-pack-year smoking history and has been managing polycythemia vera for 10 years with intermittent phlebotomy. Upon initial evaluation, she appears alert and has a distended abdomen with shifting dullness and tender hepatomegaly. What is the probable diagnosis based on these observations?
Your Answer: Budd-Chiari syndrome
Explanation:Budd-Chiari syndrome is the correct diagnosis for this patient, as it is caused by hepatic vein thrombosis. The patient has significant risk factors for thrombophilia and is presenting with the classic triad of right upper quadrant abdominal pain, ascites (as evidenced by shifting dullness on examination), and hepatomegaly.
While decompensated cirrhosis can also cause ascites and hepatomegaly, it is unlikely to cause an acute abdomen and is more likely to present with associated jaundice and encephalopathy. Therefore, this option is incorrect.
Right-sided heart failure can also lead to ascites due to raised portosystemic pressure, but this option is incorrect as the patient does not have risk factors for heart failure apart from smoking and does not have other typical findings of heart failure such as dyspnea and peripheral edema.
Nephrotic syndrome can also cause ascites due to hypoalbuminemia-related fluid retention, but there is no mention of proteinuria or hypoalbuminemia, which typically causes peri-orbital edema. Therefore, this option is also incorrect.
Understanding Budd-Chiari Syndrome
Budd-Chiari syndrome, also known as hepatic vein thrombosis, is a condition that is often associated with an underlying hematological disease or another procoagulant condition. The causes of this syndrome include polycythemia rubra vera, thrombophilia, pregnancy, and the use of combined oral contraceptive pills. The symptoms of Budd-Chiari syndrome typically include sudden onset and severe abdominal pain, ascites leading to abdominal distension, and tender hepatomegaly.
To diagnose Budd-Chiari syndrome, an ultrasound with Doppler flow studies is usually the initial radiological investigation. This test is highly sensitive and can help identify the presence of the condition. It is important to diagnose and treat Budd-Chiari syndrome promptly to prevent complications such as liver failure and portal hypertension.
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This question is part of the following fields:
- Gastrointestinal System
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Question 91
Correct
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During a splenectomy, which structure will need to be divided in a 33-year-old man?
Your Answer: Short gastric vessels
Explanation:When performing a splenectomy, it is necessary to cut the short gastric vessels located in the gastrosplenic ligament. The mobilization of the splenic flexure of the colon may also be required, but it is unlikely that it will need to be cut. This is because it is a critical area that would require a complete colonic resection if it were divided.
Understanding the Anatomy of the Spleen
The spleen is a vital organ in the human body, serving as the largest lymphoid organ. It is located below the 9th-12th ribs and has a clenched fist shape. The spleen is an intraperitoneal organ, and its peritoneal attachments condense at the hilum, where the vessels enter the spleen. The blood supply of the spleen is from the splenic artery, which is derived from the coeliac axis, and the splenic vein, which is joined by the IMV and unites with the SMV.
The spleen is derived from mesenchymal tissue during embryology. It weighs between 75-150g and has several relations with other organs. The diaphragm is superior to the spleen, while the gastric impression is anterior, the kidney is posterior, and the colon is inferior. The hilum of the spleen is formed by the tail of the pancreas and splenic vessels. The spleen also forms the apex of the lesser sac, which contains short gastric vessels.
In conclusion, understanding the anatomy of the spleen is crucial in comprehending its functions and the role it plays in the human body. The spleen’s location, weight, and relations with other organs are essential in diagnosing and treating spleen-related conditions.
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This question is part of the following fields:
- Gastrointestinal System
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Question 92
Correct
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A 65-year-old man presents to the clinic with a complaint of losing 1 stone in weight over the past three months. Apart from this, he has no significant medical history. During the physical examination, his abdomen is soft, and no palpable masses are detected. A normal PR examination is also observed. The patient's blood tests reveal a haemoglobin level of 80 g/L (120-160) and an MCV of 70 fL (80-96). What is the most appropriate initial investigation for this patient?
Your Answer: Upper GI endoscopy and colonoscopy
Explanation:Possible GI Malignancy in a Man with Weight Loss and Microcytic Anaemia
This man is experiencing weight loss and has an unexplained microcytic anaemia. The most probable cause of his blood loss is from the gastrointestinal (GI) tract, as there is no other apparent explanation. This could be due to an occult GI malignancy, which is why the recommended initial investigations are upper and lower GI endoscopy. These tests will help to identify any potential sources of bleeding in the GI tract and determine if there is an underlying malignancy. It is important to diagnose and treat any potential malignancy as early as possible to improve the patient’s prognosis. Therefore, prompt investigation and management are crucial in this case.
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This question is part of the following fields:
- Gastrointestinal System
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Question 93
Correct
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A patient with gastric ulcers has been diagnosed with significantly low levels of somatostatin. The medical consultant suspects that a particular type of cell found in both the pancreas and stomach is affected, leading to the disruption of somatostatin release.
Which type of cell is impacted in this case?Your Answer: D cells
Explanation:Somatostatin is released by D cells found in both the pancreas and stomach. These cells release somatostatin to inhibit the hormone gastrin and reduce gastric secretions. The patient’s low levels of somatostatin may have led to an increase in gastrin secretion and stomach acid, potentially causing gastric ulcers. G cells secrete gastrin, while parietal cells secrete gastric acid. Pancreatic cells is too general of a term and does not specify the specific type of cell responsible for somatostatin production.
Overview of Gastrointestinal Hormones
Gastrointestinal hormones play a crucial role in the digestion and absorption of food. These hormones are secreted by various cells in the stomach and small intestine in response to different stimuli such as the presence of food, pH changes, and neural signals.
One of the major hormones involved in food digestion is gastrin, which is secreted by G cells in the antrum of the stomach. Gastrin increases acid secretion by gastric parietal cells, stimulates the secretion of pepsinogen and intrinsic factor, and increases gastric motility. Another hormone, cholecystokinin (CCK), is secreted by I cells in the upper small intestine in response to partially digested proteins and triglycerides. CCK increases the secretion of enzyme-rich fluid from the pancreas, contraction of the gallbladder, and relaxation of the sphincter of Oddi. It also decreases gastric emptying and induces satiety.
Secretin is another hormone secreted by S cells in the upper small intestine in response to acidic chyme and fatty acids. Secretin increases the secretion of bicarbonate-rich fluid from the pancreas and hepatic duct cells, decreases gastric acid secretion, and has a trophic effect on pancreatic acinar cells. Vasoactive intestinal peptide (VIP) is a neural hormone that stimulates secretion by the pancreas and intestines and inhibits acid secretion.
Finally, somatostatin is secreted by D cells in the pancreas and stomach in response to fat, bile salts, and glucose in the intestinal lumen. Somatostatin decreases acid and pepsin secretion, decreases gastrin secretion, decreases pancreatic enzyme secretion, and decreases insulin and glucagon secretion. It also inhibits the trophic effects of gastrin and stimulates gastric mucous production.
In summary, gastrointestinal hormones play a crucial role in regulating the digestive process and maintaining homeostasis in the gastrointestinal tract.
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This question is part of the following fields:
- Gastrointestinal System
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Question 94
Correct
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A 56-year-old accountant presents to the hospital with severe abdominal pain that has been ongoing for more than 3 hours. The pain is sharp and extends to his back, and he rates it as 8/10 on the pain scale. The pain subsides when he sits up. During the examination, he appears restless, cold, and clammy, with a pulse rate of 124 bpm and a blood pressure of 102/65. You notice some purple discoloration in his right flank, and his bowel sounds are normal. According to his social history, he has a history of excessive alcohol consumption. What is the most probable diagnosis?
Your Answer: Acute pancreatitis
Explanation:Pancreatitis is the most probable diagnosis due to several reasons. Firstly, the patient’s history indicates that he is an alcoholic, which is a risk factor for pancreatitis. Secondly, the severe and radiating pain to the back is a typical symptom of pancreatitis. Additionally, the patient shows signs of jaundice and circulation collapse, with a purple discoloration known as Grey Turner’s sign caused by retroperitoneal hemorrhage. On the other hand, appendicitis pain is usually colicky, localized in the lower right quadrant, and moves up centrally. Although circulation collapse may indicate intestinal obstruction, the absence of vomiting/nausea makes it less likely. Chronic kidney disease can be ruled out as it presents with symptoms such as weight loss, tiredness, bone pain, and itchy skin, which are not present in this acute presentation. Lastly, if there was a significant history of recent surgery, ileus and obstruction would be more likely, and the absence of bowel sounds would support this diagnosis.
Acute pancreatitis is a condition that is primarily caused by gallstones and alcohol consumption in the UK. However, there are other factors that can contribute to the development of this condition. A popular mnemonic used to remember these factors is GET SMASHED, which stands for gallstones, ethanol, trauma, steroids, mumps, autoimmune diseases, scorpion venom, hypertriglyceridaemia, hyperchylomicronaemia, hypercalcaemia, hypothermia, ERCP, and certain drugs. It is important to note that pancreatitis is seven times more common in patients taking mesalazine than sulfasalazine. CT scans can show diffuse parenchymal enlargement with oedema and indistinct margins in patients with acute pancreatitis.
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This question is part of the following fields:
- Gastrointestinal System
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Question 95
Correct
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Which one of the following is not true of gastric cancer?
Your Answer: Individuals with histological evidence of signet ring cells have a lower incidence of lymph node metastasis
Explanation:Poorly differentiated gastric cancer is characterized by the presence of signet ring cells, which is linked to a higher likelihood of metastasis.
Gastric cancer is a relatively uncommon type of cancer, accounting for only 2% of all cancer diagnoses in developed countries. It is more prevalent in older individuals, with half of patients being over the age of 75, and is more common in males than females. Several risk factors have been identified, including Helicobacter pylori infection, atrophic gastritis, certain dietary habits, smoking, and blood group. Symptoms of gastric cancer can include abdominal pain, weight loss, nausea, vomiting, and dysphagia. In some cases, lymphatic spread may result in the appearance of nodules in the left supraclavicular lymph node or periumbilical area. Diagnosis is typically made through oesophago-gastro-duodenoscopy with biopsy, and staging is done using CT. Treatment options depend on the extent and location of the cancer and may include endoscopic mucosal resection, partial or total gastrectomy, and chemotherapy.
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This question is part of the following fields:
- Gastrointestinal System
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Question 96
Correct
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A 24-year-old male patient visits the GP with recurring diarrhoea and urinary symptoms. The patient is currently undergoing tests for inflammatory bowel disease (IBD). He reports dysuria and describes his urine as dark brown and frothy. What aspect of IBD is likely responsible for these symptoms?
Your Answer: Fistula
Explanation:Fistulas are often seen in patients with Crohn’s disease due to the erosion of the submucosal layer, which can lead to full-thickness ulcers. If these ulcers penetrate the bowel and reach the bladder, they can create a pathway for undigested food to enter the bladder.
While bloody stool is commonly associated with ulcerative colitis (UC), it can also occur in Crohn’s disease. However, this symptom alone cannot explain the patient’s urinary tract infections or the passing of tomato skin.
Crypt abscesses are not present in Crohn’s disease and are only associated with UC. Therefore, they cannot explain the patient’s symptoms.
Goblet cell loss, which refers to the loss of mucin-secreting cells in the intestine, is only seen in UC and not in Crohn’s disease.
Inflammatory bowel disease (IBD) is a condition that includes two main types: Crohn’s disease and ulcerative colitis. Although they share many similarities in terms of symptoms, diagnosis, and treatment, there are some key differences between the two. Crohn’s disease is characterized by non-bloody diarrhea, weight loss, upper gastrointestinal symptoms, mouth ulcers, perianal disease, and a palpable abdominal mass in the right iliac fossa. On the other hand, ulcerative colitis is characterized by bloody diarrhea, abdominal pain in the left lower quadrant, tenesmus, gallstones, and primary sclerosing cholangitis. Complications of Crohn’s disease include obstruction, fistula, and colorectal cancer, while ulcerative colitis has a higher risk of colorectal cancer than Crohn’s disease. Pathologically, Crohn’s disease lesions can be seen anywhere from the mouth to anus, while ulcerative colitis inflammation always starts at the rectum and never spreads beyond the ileocaecal valve. Endoscopy and radiology can help diagnose and differentiate between the two types of IBD.
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This question is part of the following fields:
- Gastrointestinal System
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Question 97
Correct
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A case of ischaemic left colon is diagnosed in a patient. Which artery, originating from the aorta at approximately the level of L3, is the most probable cause of this condition?
Your Answer: Inferior mesenteric artery
Explanation:The left side of the colon is most likely to be affected by the IMA, which typically originates at L3.
The Inferior Mesenteric Artery: Supplying the Hindgut
The inferior mesenteric artery (IMA) is responsible for supplying the embryonic hindgut with blood. It originates just above the aortic bifurcation, at the level of L3, and passes across the front of the aorta before settling on its left side. At the point where the left common iliac artery is located, the IMA becomes the superior rectal artery.
The hindgut, which includes the distal third of the colon and the rectum above the pectinate line, is supplied by the IMA. The left colic artery is one of the branches that emerges from the IMA near its origin. Up to three sigmoid arteries may also exit the IMA to supply the sigmoid colon further down the line.
Overall, the IMA plays a crucial role in ensuring that the hindgut receives the blood supply it needs to function properly. Its branches help to ensure that the colon and rectum are well-nourished and able to carry out their important digestive functions.
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This question is part of the following fields:
- Gastrointestinal System
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Question 98
Correct
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During an Ivor Lewis Oesophagectomy for carcinoma of the upper third of the oesophagus which structure is divided to allow mobilisation of the oesophagus?
Your Answer: Azygos vein
Explanation:The azygos vein is divided during oesophagectomy to allow mobilisation. It inserts into the SVC on the right side.
Treatment Options for Oesophageal Cancer
Oesophageal cancer is typically treated through surgical resection, with neoadjuvant chemotherapy given prior to the procedure. In situ disease may be managed through endoscopic mucosal resection, while unresectable disease may benefit from local ablative procedures, palliative chemotherapy, or stent insertion. However, resections are not typically offered to patients with distant metastasis or N2 disease, and local nodal involvement is not a contraindication to resection.
For lower and middle third oesophageal tumours, an Ivor-Lewis procedure is commonly performed. This involves a combined laparotomy and right thoracotomy, with the stomach mobilized through a rooftop incision and the oesophagus removed through a thoracotomy. The chest is then closed with underwater seal drainage and tube drains to the abdominal cavity. Postoperatively, patients will typically recover in the intensive care unit and may experience complications such as atelectasis, anastomotic leakage, and delayed gastric emptying.
Overall, treatment options for oesophageal cancer depend on the extent of the disease and the patient’s individual circumstances. While surgical resection is the mainstay of treatment, other options such as chemotherapy and local ablative procedures may be considered for unresectable disease.
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This question is part of the following fields:
- Gastrointestinal System
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Question 99
Correct
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A 25-year-old male with a history of Crohn's disease visits his gastroenterologist for a routine checkup. During the appointment, he inquires about the underlying cause of his condition. Which gene variations have been associated with Crohn's disease?
Your Answer: NOD-2
Explanation:The development of Crohn’s disease is connected to a genetic abnormality in the NOD-2 gene.
Phenylketonuria is linked to the PKU mutation.
Cystic fibrosis is associated with the CFTR mutation.
Ehlers-Danlos syndrome is connected to the COL1A1 mutation.
Understanding Crohn’s Disease
Crohn’s disease is a type of inflammatory bowel disease that can affect any part of the digestive tract, from the mouth to the anus. The exact cause of Crohn’s disease is unknown, but there is a strong genetic component. Inflammation occurs in all layers of the affected area, which can lead to complications such as strictures, fistulas, and adhesions.
Symptoms of Crohn’s disease typically appear in late adolescence or early adulthood and can include non-specific symptoms such as weight loss and lethargy, as well as more specific symptoms like diarrhea, abdominal pain, and perianal disease. Extra-intestinal features, such as arthritis, erythema nodosum, and osteoporosis, are also common in patients with Crohn’s disease.
To diagnose Crohn’s disease, doctors may look for raised inflammatory markers, increased faecal calprotectin, anemia, and low levels of vitamin B12 and vitamin D. It’s important to note that Crohn’s disease shares some features with ulcerative colitis, another type of inflammatory bowel disease, but there are also important differences between the two conditions. Understanding the symptoms and diagnostic criteria for Crohn’s disease can help patients and healthcare providers manage this chronic condition more effectively.
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This question is part of the following fields:
- Gastrointestinal System
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Question 100
Correct
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Which one of the following is not produced by the parietal cells?
Your Answer: Mucus
Explanation:The chief cells responsible for producing Pepsi cola are not to be confused with the chief cells found in the stomach. In the stomach, chief cells secrete pepsinogen, while parietal cells secrete HCl, Ca, Na, Mg, and intrinsic factor. Additionally, surface mucosal cells secrete mucus and bicarbonate.
Understanding Gastric Secretions for Surgical Procedures
A basic understanding of gastric secretions is crucial for surgeons, especially when dealing with patients who have undergone acid-lowering procedures or are prescribed anti-secretory drugs. Gastric acid, produced by the parietal cells in the stomach, has a pH of around 2 and is maintained by the H+/K+ ATPase pump. Sodium and chloride ions are actively secreted from the parietal cell into the canaliculus, creating a negative potential across the membrane. Carbonic anhydrase forms carbonic acid, which dissociates, and the hydrogen ions formed by dissociation leave the cell via the H+/K+ antiporter pump. This leaves hydrogen and chloride ions in the canaliculus, which mix and are secreted into the lumen of the oxyntic gland.
There are three phases of gastric secretion: the cephalic phase, gastric phase, and intestinal phase. The cephalic phase is stimulated by the smell or taste of food and causes 30% of acid production. The gastric phase, which is caused by stomach distension, low H+, or peptides, causes 60% of acid production. The intestinal phase, which is caused by high acidity, distension, or hypertonic solutions in the duodenum, inhibits gastric acid secretion via enterogastrones and neural reflexes.
The regulation of gastric acid production involves various factors that increase or decrease production. Factors that increase production include vagal nerve stimulation, gastrin release, and histamine release. Factors that decrease production include somatostatin, cholecystokinin, and secretin. Understanding these factors and their associated pharmacology is essential for surgeons.
In summary, a working knowledge of gastric secretions is crucial for surgical procedures, especially when dealing with patients who have undergone acid-lowering procedures or are prescribed anti-secretory drugs. Understanding the phases of gastric secretion and the regulation of gastric acid production is essential for successful surgical outcomes.
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This question is part of the following fields:
- Gastrointestinal System
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Question 101
Correct
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During an abdominal aortic aneurysm repair, a 78-year-old man has two clamps placed on his aorta, with the inferior clamp positioned at the point of aortic bifurcation. Which vertebral body will be located posterior to the clamp at this level?
Your Answer: L4
Explanation:The point at which the aorta divides into two branches is known as the bifurcation, which is a crucial anatomical landmark that is frequently assessed. This bifurcation typically occurs at the level of the fourth lumbar vertebrae (L4).
The abdominal aorta is a major blood vessel that originates from the 12th thoracic vertebrae and terminates at the fourth lumbar vertebrae. It is located in the abdomen and is surrounded by various organs and structures. The posterior relations of the abdominal aorta include the vertebral bodies of the first to fourth lumbar vertebrae. The anterior relations include the lesser omentum, liver, left renal vein, inferior mesenteric vein, third part of the duodenum, pancreas, parietal peritoneum, and peritoneal cavity. The right lateral relations include the right crus of the diaphragm, cisterna chyli, azygos vein, and inferior vena cava (which becomes posterior distally). The left lateral relations include the fourth part of the duodenum, duodenal-jejunal flexure, and left sympathetic trunk. Overall, the abdominal aorta is an important blood vessel that supplies oxygenated blood to various organs in the abdomen.
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This question is part of the following fields:
- Gastrointestinal System
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Question 102
Correct
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A 15-year-old boy, with a family history of Gilbert's syndrome, is showing symptoms of hepatic dysfunction. Upon conducting liver function tests, it is found that he has elevated levels of unconjugated bilirubin. After genetic testing, it is confirmed that he has Gilbert's syndrome. What is the reason behind the increased levels of unconjugated bilirubin in Gilbert's syndrome?
Your Answer: Reduced levels of UDP-glucuronosyl transferase-1
Explanation:Gilbert’s syndrome is characterized by a decrease in UDP glucuronosyltransferase levels.
Enhanced drug effects can occur due to reduced warfarin metabolism caused by CYP2C9 deficiency.
Elevated GGT levels are often caused by pancreatic disease, cholestasis, excessive alcohol consumption, and certain medications.
Dubin-Johnson syndrome is associated with defective hepatocyte excretion of conjugated bilirubin.
Disordered metabolism of clopidogrel and other drugs, including proton-pump inhibitors, anticonvulsants, and sedatives, can result from reduced CYP2C19 levels.Gilbert’s syndrome is a genetic disorder that affects the way bilirubin is processed in the body. It is caused by a deficiency of UDP glucuronosyltransferase, which leads to unconjugated hyperbilirubinemia. This means that bilirubin is not properly broken down and eliminated from the body, resulting in jaundice. However, jaundice may only be visible during certain conditions such as fasting, exercise, or illness. The prevalence of Gilbert’s syndrome is around 1-2% in the general population.
To diagnose Gilbert’s syndrome, doctors may look for a rise in bilirubin levels after prolonged fasting or the administration of IV nicotinic acid. However, treatment is not necessary for this condition. While the exact mode of inheritance is still debated, it is known to be an autosomal recessive disorder.
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This question is part of the following fields:
- Gastrointestinal System
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Question 103
Incorrect
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A 50-year-old man has been diagnosed with a gastrointestinal stromal tumour in his stomach. What is the typical cell type that gives rise to these tumours?
Your Answer: Brunner's glands
Correct Answer: Interstitial cells of Cajal
Explanation:Gastrointestinal stromal tumors (GISTs) originate from Cajal’s interstitial pacemaker cells, which are typically found outside the mucosal layer and cause minimal damage to it.
Gastrointestinal Stromal Tumours: Characteristics and Treatment Options
Gastrointestinal stromal tumours (GISTs) are rare tumours that originate from the interstitial pacemaker cells of Cajal. These tumours are primarily found in the stomach (70%), with the remainder occurring in the small intestine (20%) and colon/rectum (5%). Most GISTs are solitary lesions and are sporadic in nature. The majority of GISTs express CD117, a transmembrane tyrosine kinase receptor, and have a mutation of the c-KIT gene.
The main goal of surgery for GISTs is to resect the tumour with a 1-2 cm margin of normal tissue. Extensive resections are not usually required. However, there is a high local recurrence rate, which is related to the site of the tumour, incomplete resections, and high mitotic count. Salvage surgery for recurrent disease is associated with a median survival of 15 months.
In high-risk patients, the use of imatinib has greatly improved prognosis. In the ACOSOG trial, imatinib reduced relapse rates from 17% to 2%. In the UK, imatinib is recommended by NICE for use in patients with metastatic disease or locally unresectable disease.
Overall, GISTs are rare tumours that require careful management. Surgery with a margin of normal tissue is the mainstay of treatment, but the risk of recurrence is high. Imatinib has shown promise in improving prognosis for high-risk patients.
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This question is part of the following fields:
- Gastrointestinal System
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Question 104
Correct
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A 28-year-old woman presents to her GP with a complaint of diarrhoea lasting for 5 months. She reports the presence of blood in her stool and feeling excessively fatigued.
During abdominal examination, tenderness is noted in the lower left quadrant.
The patient is referred for a colonoscopy and biopsy.
What characteristic would you anticipate finding based on the probable diagnosis?Your Answer: Inflammation from rectum extending proximally
Explanation:Ulcerative colitis is a form of inflammatory bowel disease that usually manifests with symptoms like fatigue, left lower quadrant pain, and bloody diarrhoea. The inflammation associated with ulcerative colitis starts at the rectum and extends proximally, but it does not spread beyond the ileocaecal valve.
Unlike Crohn’s disease, ulcerative colitis does not typically present with a cobblestone appearance during colonoscopy.
While diverticula can cause rectal bleeding and abdominal pain, they are more common in older patients and would not be expected in a patient of this age.
In Crohn’s disease, skip lesions are present, whereas in ulcerative colitis, the inflammation is continuous.
Inflammatory bowel disease (IBD) is a condition that includes two main types: Crohn’s disease and ulcerative colitis. Although they share many similarities in terms of symptoms, diagnosis, and treatment, there are some key differences between the two. Crohn’s disease is characterized by non-bloody diarrhea, weight loss, upper gastrointestinal symptoms, mouth ulcers, perianal disease, and a palpable abdominal mass in the right iliac fossa. On the other hand, ulcerative colitis is characterized by bloody diarrhea, abdominal pain in the left lower quadrant, tenesmus, gallstones, and primary sclerosing cholangitis. Complications of Crohn’s disease include obstruction, fistula, and colorectal cancer, while ulcerative colitis has a higher risk of colorectal cancer than Crohn’s disease. Pathologically, Crohn’s disease lesions can be seen anywhere from the mouth to anus, while ulcerative colitis inflammation always starts at the rectum and never spreads beyond the ileocaecal valve. Endoscopy and radiology can help diagnose and differentiate between the two types of IBD.
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This question is part of the following fields:
- Gastrointestinal System
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Question 105
Correct
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A 32-year-old woman presents with a 14-day history of profuse, watery diarrhoea. She denies the presence of blood. There is no history of recent travel. The diarrhoea is stopping her from going to work, and so she has been forced to take unpaid leave. She wants to return to work as she is the sole breadwinner for the family.
On examination, she is apyrexial but looks clinically dehydrated.
After ruling out infection and inflammatory bowel disease, you prescribe a short course of loperamide to help slow down her bowel movements.
What is the mechanism of action of the prescribed anti-diarrhoeal medication?Your Answer: Agonist of μ-opioid receptors in the myenteric plexus of the large intestine
Explanation:The myenteric plexus of the large intestine’s μ-opioid receptors are targeted by loperamide.
Antidiarrhoeal Agents: Opioid Agonists
Antidiarrhoeal agents are medications used to treat diarrhoea. Opioid agonists are a type of antidiarrhoeal agent that work by slowing down the movement of the intestines, which reduces the frequency and urgency of bowel movements. Two common opioid agonists used for this purpose are loperamide and diphenoxylate.
Loperamide is available over-the-counter and is often used to treat acute diarrhoea. It works by binding to opioid receptors in the intestines, which reduces the contractions of the muscles in the intestinal wall. This slows down the movement of food and waste through the intestines, allowing more time for water to be absorbed and resulting in firmer stools.
Diphenoxylate is a prescription medication that is often used to treat chronic diarrhoea. It works in a similar way to loperamide, but is often combined with atropine to discourage abuse and overdose.
Overall, opioid agonists are effective at treating diarrhoea, but should be used with caution and under the guidance of a healthcare professional. They can cause side effects such as constipation, dizziness, and nausea, and may interact with other medications.
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This question is part of the following fields:
- Gastrointestinal System
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Question 106
Correct
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Which one of the following statements relating to the pancreas is not true?
Your Answer: Cholecystokinin causes relaxation of the gallbladder
Explanation:The contraction of the gallbladder is caused by CCK.
The gallbladder is a sac made of fibromuscular tissue that can hold up to 50 ml of fluid. Its lining is made up of columnar epithelium. The gallbladder is located in close proximity to various organs, including the liver, transverse colon, and the first part of the duodenum. It is covered by peritoneum and is situated between the right lobe and quadrate lobe of the liver. The gallbladder receives its arterial supply from the cystic artery, which is a branch of the right hepatic artery. Its venous drainage is directly to the liver, and its lymphatic drainage is through Lund’s node. The gallbladder is innervated by both sympathetic and parasympathetic nerves. The common bile duct originates from the confluence of the cystic and common hepatic ducts and is located in the hepatobiliary triangle, which is bordered by the common hepatic duct, cystic duct, and the inferior edge of the liver. The cystic artery is also found within this triangle.
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This question is part of the following fields:
- Gastrointestinal System
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Question 107
Incorrect
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Which of the following is not a branch of the abdominal aorta?
Your Answer: Inferior phrenic artery
Correct Answer: Superior phrenic artery
Explanation:To remember the order of branches, use the phrase ‘Prostitutes Cause Sagging Swollen Red Testicles [in men] Living In Sin’:
Phrenic [inferior]
Celiac
Superior mesenteric
Suprarenal [middle]
Renal
Testicular [‘in men’ only]
Lumbars
Inferior mesenteric
SacralNote that the superior phrenic artery branches from the aorta in the thorax.
Branches of the Abdominal Aorta
The abdominal aorta is a major blood vessel that supplies oxygenated blood to the abdominal organs and lower extremities. It gives rise to several branches that supply blood to various organs and tissues. These branches can be classified into two types: parietal and visceral.
The parietal branches supply blood to the walls of the abdominal cavity, while the visceral branches supply blood to the abdominal organs. The branches of the abdominal aorta include the inferior phrenic, coeliac, superior mesenteric, middle suprarenal, renal, gonadal, lumbar, inferior mesenteric, median sacral, and common iliac arteries.
The inferior phrenic artery arises from the upper border of the abdominal aorta and supplies blood to the diaphragm. The coeliac artery supplies blood to the liver, stomach, spleen, and pancreas. The superior mesenteric artery supplies blood to the small intestine, cecum, and ascending colon. The middle suprarenal artery supplies blood to the adrenal gland. The renal arteries supply blood to the kidneys. The gonadal arteries supply blood to the testes or ovaries. The lumbar arteries supply blood to the muscles and skin of the back. The inferior mesenteric artery supplies blood to the descending colon, sigmoid colon, and rectum. The median sacral artery supplies blood to the sacrum and coccyx. The common iliac arteries are the terminal branches of the abdominal aorta and supply blood to the pelvis and lower extremities.
Understanding the branches of the abdominal aorta is important for diagnosing and treating various medical conditions that affect the abdominal organs and lower extremities.
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This question is part of the following fields:
- Gastrointestinal System
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Question 108
Correct
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A 28-year-old woman presents with fatigue, low energy, and lethargy. She has a medical history of migraine, ulcerative colitis, depression, and generalized anxiety disorder.
During the physical examination, slight pallor is noted in her eyes, but otherwise, everything appears normal.
The results of her blood test from this morning are as follows:
- Hemoglobin (Hb): 98 g/l
- Platelets: 300 * 109/l
- White blood cells (WBC): 6 * 109/l
- Mean corpuscular volume (MCV): 112
- C-reactive protein (CRP): 5 mg/L
- Erythrocyte sedimentation rate (ESR): 5 mm/hr
- Thyroid function test (TFT): normal
Based on these findings, what is the most likely cause of her symptoms and abnormal blood results?Your Answer: Long-term use of sulfasalazine
Explanation:Sulphasalazine is the likely cause of megaloblastic anaemia in this patient, as her blood results indicate macrocytic anaemia and she has a history of ulcerative colitis for which she is taking the medication. Microcytic anaemia is commonly caused by poor iron intake, while sickle cell anaemia causes microcytic anaemia. Long-term use of sumatriptan is not associated with macrocytic anaemia. Although hypothyroidism can cause macrocytic anaemia, this option is incorrect as the patient’s thyroid function tests are normal.
Aminosalicylate Drugs for Inflammatory Bowel Disease
Aminosalicylate drugs are commonly used to treat inflammatory bowel disease (IBD). These drugs work by releasing 5-aminosalicyclic acid (5-ASA) in the colon, which acts as an anti-inflammatory agent. The exact mechanism of action is not fully understood, but it is believed that 5-ASA may inhibit prostaglandin synthesis.
Sulphasalazine is a combination of sulphapyridine and 5-ASA. However, many of the side effects associated with this drug are due to the sulphapyridine component, such as rashes, oligospermia, headache, Heinz body anaemia, megaloblastic anaemia, and lung fibrosis. Mesalazine is a delayed release form of 5-ASA that avoids the sulphapyridine side effects seen in patients taking sulphasalazine. However, it is still associated with side effects such as gastrointestinal upset, headache, agranulocytosis, pancreatitis, and interstitial nephritis.
Olsalazine is another aminosalicylate drug that consists of two molecules of 5-ASA linked by a diazo bond, which is broken down by colonic bacteria. It is important to note that aminosalicylates are associated with a variety of haematological adverse effects, including agranulocytosis. Therefore, a full blood count is a key investigation in an unwell patient taking these drugs. Pancreatitis is also more common in patients taking mesalazine compared to sulfasalazine.
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This question is part of the following fields:
- Gastrointestinal System
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Question 109
Incorrect
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A 76-year-old man is undergoing a femoro-popliteal bypass graft. The surgery is not going smoothly, and the surgeon is having difficulty accessing the area. Which structure needs to be retracted to improve access to the femoral artery in the groin?
Your Answer: Pectineus
Correct Answer: Sartorius
Explanation:To enhance accessibility, the sartorius muscle can be pulled back as the femoral artery passes beneath it at the lower boundary of the femoral triangle.
Understanding the Anatomy of the Femoral Triangle
The femoral triangle is an important anatomical region located in the upper thigh. It is bounded by the inguinal ligament superiorly, the sartorius muscle laterally, and the adductor longus muscle medially. The floor of the femoral triangle is made up of the iliacus, psoas major, adductor longus, and pectineus muscles, while the roof is formed by the fascia lata and superficial fascia. The superficial inguinal lymph nodes and the long saphenous vein are also found in this region.
The femoral triangle contains several important structures, including the femoral vein, femoral artery, femoral nerve, deep and superficial inguinal lymph nodes, lateral cutaneous nerve, great saphenous vein, and femoral branch of the genitofemoral nerve. The femoral artery can be palpated at the mid inguinal point, making it an important landmark for medical professionals.
Understanding the anatomy of the femoral triangle is important for medical professionals, as it is a common site for procedures such as venipuncture, arterial puncture, and nerve blocks. It is also important for identifying and treating conditions that affect the structures within this region, such as femoral hernias and lymphadenopathy.
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This question is part of the following fields:
- Gastrointestinal System
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Question 110
Correct
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A 65-year-old man visits his GP complaining of watery diarrhoea that has persisted for a month. He denies any alterations to his diet or recent international travel. The patient's weight has remained stable.
During an abdominal ultrasound, a pancreatic nodule is discovered. Upon biopsy, it is determined that the nodule originates from pancreatic S cells.
What hormone is expected to be secreted by the pancreatic nodule?Your Answer: Secretin
Explanation:The correct answer is Secretin. S cells in the upper small intestine secrete this gastrointestinal hormone, which promotes the secretion of bicarbonate-rich fluid from the pancreas. Pancreatic secretinomas, a rare type of gastrointestinal neuroendocrine tumor, can cause watery diarrhea.
Cholecystokinin is another gastrointestinal hormone that promotes the contraction of the gallbladder and the secretion of bile at the ampulla of Vater. However, it does not promote the secretion of bicarbonate-rich fluid from the pancreas.
Gastrin is a gastrointestinal hormone that promotes gastric motility and the secretion of hydrochloric acid by parietal cells. It is released by the G cells of the gastric antrum.
Motilin is a gastrointestinal hormone secreted by M cells within Peyer’s patches of the small intestine, which promotes gastrointestinal motility.
Overview of Gastrointestinal Hormones
Gastrointestinal hormones play a crucial role in the digestion and absorption of food. These hormones are secreted by various cells in the stomach and small intestine in response to different stimuli such as the presence of food, pH changes, and neural signals.
One of the major hormones involved in food digestion is gastrin, which is secreted by G cells in the antrum of the stomach. Gastrin increases acid secretion by gastric parietal cells, stimulates the secretion of pepsinogen and intrinsic factor, and increases gastric motility. Another hormone, cholecystokinin (CCK), is secreted by I cells in the upper small intestine in response to partially digested proteins and triglycerides. CCK increases the secretion of enzyme-rich fluid from the pancreas, contraction of the gallbladder, and relaxation of the sphincter of Oddi. It also decreases gastric emptying and induces satiety.
Secretin is another hormone secreted by S cells in the upper small intestine in response to acidic chyme and fatty acids. Secretin increases the secretion of bicarbonate-rich fluid from the pancreas and hepatic duct cells, decreases gastric acid secretion, and has a trophic effect on pancreatic acinar cells. Vasoactive intestinal peptide (VIP) is a neural hormone that stimulates secretion by the pancreas and intestines and inhibits acid secretion.
Finally, somatostatin is secreted by D cells in the pancreas and stomach in response to fat, bile salts, and glucose in the intestinal lumen. Somatostatin decreases acid and pepsin secretion, decreases gastrin secretion, decreases pancreatic enzyme secretion, and decreases insulin and glucagon secretion. It also inhibits the trophic effects of gastrin and stimulates gastric mucous production.
In summary, gastrointestinal hormones play a crucial role in regulating the digestive process and maintaining homeostasis in the gastrointestinal tract.
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This question is part of the following fields:
- Gastrointestinal System
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Question 111
Correct
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A 2-year-old boy with no significant medical history is brought to the ER by his mother due to a week-long crying spell and passing bright red stools. The patient cries loudly upon palpation of the right lower quadrant. Meckel's diverticulum is confirmed through a positive technetium-99m scan. What is the embryological source of this abnormality?
Your Answer: Omphalomesenteric duct
Explanation:The correct answer is omphalomesenteric duct, which is the precursor to Meckel’s diverticulum. Meckel’s diverticulum is a true diverticulum that forms due to the persistence of this duct and may contain gastric or pancreatic tissue. It is the most common congenital anomaly of the GI tract and can present with various symptoms.
Auerbach plexus is an incorrect answer. Its absence is associated with Hirschsprung disease or achalasia.
Fetal umbilical vein is also incorrect. It becomes the ligamentum teres hepatis within the falciform ligament of the liver.
Pleuroperitoneal membrane is another incorrect answer. A congenital defect in this structure can lead to a left-sided diaphragmatic hernia in infants.
Meckel’s diverticulum is a congenital diverticulum of the small intestine that is a remnant of the omphalomesenteric duct. It occurs in 2% of the population, is 2 feet from the ileocaecal valve, and is 2 inches long. It is usually asymptomatic but can present with abdominal pain, rectal bleeding, or intestinal obstruction. Investigation includes a Meckel’s scan or mesenteric arteriography. Management involves removal if narrow neck or symptomatic, with options between wedge excision or formal small bowel resection and anastomosis. Meckel’s diverticulum is typically lined by ileal mucosa but ectopic gastric, pancreatic, and jejunal mucosa can also occur.
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This question is part of the following fields:
- Gastrointestinal System
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Question 112
Incorrect
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A 25-year-old male has been referred to the clinic due to a family history of colorectal cancer. Genetic testing revealed a mutation of the APC gene, and a colonoscopy is recommended. What is the probable outcome of the procedure?
Your Answer: Multiple colonic hamartomas
Correct Answer: Multiple colonic adenomas
Explanation:Familial adenomatous polyposis coli is characterized by the presence of multiple colonic adenomas, which are caused by mutations in the APC gene.
Polyposis syndromes are a group of genetic disorders that cause the development of multiple polyps in the colon and other parts of the gastrointestinal tract. These polyps can increase the risk of developing cancer, and therefore, early detection and management are crucial. There are several types of polyposis syndromes, each with its own genetic defect, features, and associated disorders.
Familial adenomatous polyposis (FAP) is caused by a mutation in the APC gene and is characterized by the development of over 100 colonic adenomas, with a 100% risk of cancer. Screening and management involve regular colonoscopies and resectional surgery if polyps are found. FAP is also associated with gastric and duodenal polyps and abdominal desmoid tumors.
MYH-associated polyposis is caused by a biallelic mutation of the MYH gene and is associated with multiple colonic polyps and an increased risk of right-sided cancers. Attenuated phenotype can be managed with regular colonoscopies, while resection and ileoanal pouch reconstruction are recommended for those with multiple polyps.
Peutz-Jeghers syndrome is caused by a mutation in the STK11 gene and is characterized by multiple benign intestinal hamartomas, episodic obstruction, and an increased risk of GI cancers. Screening involves annual examinations and pan-intestinal endoscopy every 2-3 years.
Cowden disease is caused by a mutation in the PTEN gene and is characterized by macrocephaly, multiple intestinal hamartomas, and an increased risk of cancer at any site. Targeted individualized screening is recommended, with extra surveillance for breast, thyroid, and uterine cancers.
HNPCC (Lynch syndrome) is caused by germline mutations of DNA mismatch repair genes and is associated with an increased risk of colorectal, endometrial, and gastric cancers. Colonoscopies every 1-2 years from age 25 and consideration of prophylactic surgery are recommended, along with extra colonic surveillance.
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This question is part of the following fields:
- Gastrointestinal System
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Question 113
Correct
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A 4-year-old boy is brought to the GP by his mother due to concerns about his growth and weight gain. The mother has noticed that her son is smaller than other children his age and has difficulty putting on weight. Additionally, she has observed that his stools have become pale and greasy, and he frequently experiences bloating. Upon examination, the boy appears underweight and pale, with abdominal distension and muscle wasting in the buttocks. Based on this history and examination, what is the most likely diagnosis?
Your Answer: Coeliac disease
Explanation:Coeliac disease typically presents in children around the age when they start consuming wheat and cereal, but some individuals may not show symptoms until later in life. It is crucial for healthcare professionals to be able to identify this condition, both in clinical settings and for exams.
Coeliac Disease in Children: Causes, Symptoms, and Diagnosis
Coeliac disease is a condition that affects children and is caused by sensitivity to gluten, a protein found in cereals. This sensitivity leads to villous atrophy, which causes malabsorption. Children usually present with symptoms before the age of 3, coinciding with the introduction of cereals into their diet. The incidence of coeliac disease is around 1 in 100, and it is strongly associated with HLA-DQ2 and HLA-DQ8. Symptoms of coeliac disease include failure to thrive, diarrhoea, abdominal distension, and anaemia in older children. However, many cases are not diagnosed until adulthood.
Diagnosis of coeliac disease involves a jejunal biopsy showing subtotal villous atrophy, as well as screening tests for anti-endomysial and anti-gliadin antibodies. The biopsy shows complete atrophy of the villi with flat mucosa and marked crypt hyperplasia, as well as dense mixed inflammatory infiltrate in the lamina propria. Another biopsy may show flat mucosa with hyperplastic crypts and dense cellular infiltrate in the lamina propria, as well as an increased number of intraepithelial lymphocytes and vacuolated superficial epithelial cells. Overall, coeliac disease is a serious condition that requires early diagnosis and management to prevent long-term complications.
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This question is part of the following fields:
- Gastrointestinal System
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Question 114
Correct
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A 25-year-old man presents to the hepatology clinic after his general practitioner detected abnormal liver function on routine blood tests. He has been experiencing intermittent pain in the right upper quadrant for the past 3 months. He denies any history of intravenous drug use or recent travel. He has a medical history of depression and takes citalopram daily.
During the examination, the patient exhibits tenderness in the right upper quadrant. There is no visible jaundice, but he has dark rings around his iris.
What investigation finding is associated with the probable diagnosis?Your Answer: Raised free serum copper
Explanation:Autoimmune hepatitis is a condition characterized by inflammation of the liver, which can present as acute hepatitis with symptoms such as abdominal pain, fever, and jaundice. Unlike other conditions such as Wilson’s disease, neuropsychiatric and eye signs are not typically observed in autoimmune hepatitis.
Haemochromatosis, on the other hand, is an autosomal recessive disorder that results in the accumulation and deposition of iron. A raised transferrin saturation is a sign of this condition, which can cause hepatitis, liver cirrhosis, fatigue, arthralgia, and bronze-colored skin pigmentation. If psychiatric symptoms are present, Wilson’s disease may be more likely.
α1-antitrypsin deficiency is an inherited disorder that occurs when the liver does not produce enough of the protease enzyme A1AT. This condition is primarily associated with emphysema, although liver cirrhosis may also occur. However, if there are no respiratory symptoms, α1-antitrypsin deficiency is unlikely to be the cause.
Understanding Wilson’s Disease
Wilson’s disease is a genetic disorder that causes excessive copper accumulation in the tissues due to metabolic abnormalities. It is an autosomal recessive disorder caused by a defect in the ATP7B gene located on chromosome 13. Symptoms usually appear between the ages of 10 to 25 years, with children presenting with liver disease and young adults with neurological disease.
The disease is characterised by excessive copper deposition in the tissues, particularly in the brain, liver, and cornea. This can lead to a range of symptoms, including hepatitis, cirrhosis, basal ganglia degeneration, speech and behavioural problems, asterixis, chorea, dementia, parkinsonism, Kayser-Fleischer rings, renal tubular acidosis, haemolysis, and blue nails.
To diagnose Wilson’s disease, doctors may perform a slit lamp examination for Kayser-Fleischer rings, measure serum ceruloplasmin and total serum copper (which is often reduced), and check for increased 24-hour urinary copper excretion. Genetic analysis of the ATP7B gene can confirm the diagnosis.
Treatment for Wilson’s disease typically involves chelating agents such as penicillamine or trientine hydrochloride, which help to remove excess copper from the body. Tetrathiomolybdate is a newer agent that is currently under investigation. With proper management, individuals with Wilson’s disease can lead normal lives.
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This question is part of the following fields:
- Gastrointestinal System
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Question 115
Correct
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A 10-year-old girl presents to her doctor with a 2-month history of flatulence, foul-smelling diarrhoea, and a weight loss of 2kg. Her mother reports observing greasy, floating stools during this time.
During the examination, the patient appears to be in good health. There are no palpable masses or organomegaly during abdominal examination.
The child's serum anti-tissue transglutaminase antibodies are found to be elevated. What is the most probable HLA type for this child?Your Answer: HLA-DQ2
Explanation:The HLA most commonly associated with coeliac disease is HLA-DQ2. HLA, also known as human leukocyte antigen or major histocompatibility complex, is expressed on self-cells in the body and plays a role in presenting antigens to the immune system. The child’s symptoms of coeliac disease include fatty, floaty stools (steatorrhoea), weight loss, and positive tissue transglutaminase antibodies.
HLA-A01 is not commonly associated with autoimmune conditions, but has been linked to methotrexate-induced liver cirrhosis.
HLA-B27 is associated with psoriatic arthritis, reactive arthritis, ankylosing spondylitis, and inflammatory bowel disease.
HLA-B35 is not commonly associated with autoimmune conditions.
Understanding Coeliac Disease
Coeliac disease is an autoimmune disorder that affects approximately 1% of the UK population. It is caused by sensitivity to gluten, a protein found in wheat, barley, and rye. Repeated exposure to gluten leads to villous atrophy, which causes malabsorption. Coeliac disease is associated with various conditions, including dermatitis herpetiformis and autoimmune disorders such as type 1 diabetes mellitus and autoimmune hepatitis. It is strongly linked to HLA-DQ2 and HLA-DQ8.
To diagnose coeliac disease, NICE recommends screening patients who exhibit signs and symptoms such as chronic or intermittent diarrhea, failure to thrive or faltering growth in children, persistent or unexplained gastrointestinal symptoms, prolonged fatigue, recurrent abdominal pain, sudden or unexpected weight loss, unexplained anemia, autoimmune thyroid disease, dermatitis herpetiformis, irritable bowel syndrome, type 1 diabetes, and first-degree relatives with coeliac disease.
Complications of coeliac disease include anemia, hyposplenism, osteoporosis, osteomalacia, lactose intolerance, enteropathy-associated T-cell lymphoma of the small intestine, subfertility, and unfavorable pregnancy outcomes. In rare cases, it can lead to esophageal cancer and other malignancies.
The diagnosis of coeliac disease is confirmed through a duodenal biopsy, which shows complete atrophy of the villi with flat mucosa and marked crypt hyperplasia, intraepithelial lymphocytosis, and dense mixed inflammatory infiltrate in the lamina propria. Treatment involves a lifelong gluten-free diet.
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This question is part of the following fields:
- Gastrointestinal System
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Question 116
Correct
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A previously healthy woman of 23 years-old presented with acute epigastric pain. On investigations, a largely elevated lipase was discovered with a normal amylase level, and a diagnosis of chronic pancreatitis was made. This patient rarely drinks alcohol, and ultrasonography of the abdomen ruled out gallstones. The results of tests for autoimmune pancreatitis were negative. Twenty days later, imaging tests using magnetic resonance cholangiopancreatography (MRCP) revealed the cause of the chronic pancreatitis.
What was the most probable reason behind the chronic pancreatitis in this 23-year-old woman?Your Answer: Pancreas divisum
Explanation:Pancreas divisum is a condition where the dorsal and ventral buds of the pancreas fail to fuse in a portion of the population. This can lead to chronic pancreatitis due to insufficient drainage of pancreatic secretions through the minor papilla instead of the major papilla. Other causes of chronic pancreatitis include autoimmune pancreatitis and cystic fibrosis, but these have been ruled out in this case as the patient is a previously healthy individual with negative autoimmune antibodies. Acute pancreatitis can be caused by mumps or a Trinidadian scorpion bite.
Understanding Chronic Pancreatitis
Chronic pancreatitis is a condition characterized by inflammation that can affect both the exocrine and endocrine functions of the pancreas. While alcohol excess is the leading cause of this condition, up to 20% of cases are unexplained. Other causes include genetic factors such as cystic fibrosis and haemochromatosis, as well as ductal obstruction due to tumors, stones, and structural abnormalities.
Symptoms of chronic pancreatitis include pain that worsens 15 to 30 minutes after a meal, steatorrhoea, and diabetes mellitus. Abdominal x-rays and CT scans are used to detect pancreatic calcification, which is present in around 30% of cases. Functional tests such as faecal elastase may also be used to assess exocrine function if imaging is inconclusive.
Management of chronic pancreatitis involves pancreatic enzyme supplements, analgesia, and antioxidants. While there is limited evidence to support the use of antioxidants, one study suggests that they may be beneficial in early stages of the disease. Overall, understanding the causes and symptoms of chronic pancreatitis is crucial for effective management and treatment.
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This question is part of the following fields:
- Gastrointestinal System
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Question 117
Incorrect
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A 50-year-old man presents with brisk haematemesis and is taken to the endoscopy department for an upper GI endoscopy. The gastroenterologist identifies an ulcer on the posterior duodenal wall and attempts to control the bleeding with various haemostatic techniques. After an unsuccessful attempt, the surgeon is called for assistance. During the laparotomy and anterior duodenotomy, a vessel is found spurting blood into the duodenal lumen. What is the origin of this vessel?
Your Answer: Left gastric artery
Correct Answer: Common hepatic artery
Explanation:The gastroduodenal artery originates from the common hepatic artery.
The Gastroduodenal Artery: Supply and Path
The gastroduodenal artery is responsible for supplying blood to the pylorus, proximal part of the duodenum, and indirectly to the pancreatic head through the anterior and posterior superior pancreaticoduodenal arteries. It commonly arises from the common hepatic artery of the coeliac trunk and terminates by bifurcating into the right gastroepiploic artery and the superior pancreaticoduodenal artery.
To better understand the relationship of the gastroduodenal artery to the first part of the duodenum, the stomach is reflected superiorly in an image sourced from Wikipedia. This artery plays a crucial role in providing oxygenated blood to the digestive system, ensuring proper functioning and health.
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This question is part of the following fields:
- Gastrointestinal System
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Question 118
Correct
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A 39-year-old patient visits the doctor with complaints of occasional pain in the upper right quadrant of the abdomen. The patient reports that the pain worsens after meals, particularly after a heavy dinner. There are no other accompanying symptoms, and all vital signs are within normal limits.
What is the most probable diagnosis?Your Answer: Biliary colic
Explanation:Biliary colic can cause pain after eating a meal.
Biliary colic occurs when the gallbladder contracts to release bile after a meal, but the presence of gallstones in the gallbladder causes pain during this process. The pain is typically worse after a fatty meal compared to a low-fat meal, as bile is needed to break down fat.
In contrast, duodenal ulcers cause pain that is worse on an empty stomach and relieved by eating, as food acts as a buffer between the ulcer and stomach acid. The pain from an ulcer is typically described as a burning sensation, while biliary colic causes a sharp pain.
Autoimmune hepatitis pain is unlikely to fluctuate as the patient described.
Appendicitis pain typically starts in the center of the abdomen and then moves to the lower right quadrant, known as McBurney’s point.
Ascending cholangitis is characterized by a triad of fever, pain, and jaundice, known as Charcot’s triad.
Understanding Biliary Colic and Gallstone-Related Disease
Biliary colic is a condition that occurs when gallstones pass through the biliary tree. It is more common in women, especially those who are obese, fertile, or over the age of 40. Other risk factors include diabetes, Crohn’s disease, rapid weight loss, and certain medications. Biliary colic is caused by an increase in cholesterol, a decrease in bile salts, and biliary stasis. The pain is due to the gallbladder contracting against a stone lodged in the cystic duct. Symptoms include colicky right upper quadrant abdominal pain, nausea, and vomiting. Unlike other gallstone-related conditions, there is no fever or abnormal liver function tests.
Ultrasound is the preferred diagnostic tool for biliary colic. Elective laparoscopic cholecystectomy is the recommended treatment. However, around 15% of patients may have gallstones in the common bile duct at the time of surgery, which can lead to obstructive jaundice. Other complications of gallstone-related disease include acute cholecystitis, ascending cholangitis, acute pancreatitis, gallstone ileus, and gallbladder cancer. It is important to understand the risk factors, pathophysiology, and management of biliary colic and gallstone-related disease to ensure prompt diagnosis and appropriate treatment.
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This question is part of the following fields:
- Gastrointestinal System
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Question 119
Correct
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A 26-year-old male presents with yellow discoloration of his skin. He reports having had the flu for the past week but is otherwise in good health. He vaguely remembers his uncle experiencing similar episodes of yellow skin. What is the probable diagnosis and what is the mode of inheritance for this condition?
Your Answer: Autosomal recessive
Explanation:Gilbert’s Syndrome is inherited in an autosomal recessive manner. It causes unconjugated hyperbilirubinaemia during periods of stress, such as fasting or infection.
Gilbert’s syndrome is a genetic disorder that affects the way bilirubin is processed in the body. It is caused by a deficiency of UDP glucuronosyltransferase, which leads to unconjugated hyperbilirubinemia. This means that bilirubin is not properly broken down and eliminated from the body, resulting in jaundice. However, jaundice may only be visible during certain conditions such as fasting, exercise, or illness. The prevalence of Gilbert’s syndrome is around 1-2% in the general population.
To diagnose Gilbert’s syndrome, doctors may look for a rise in bilirubin levels after prolonged fasting or the administration of IV nicotinic acid. However, treatment is not necessary for this condition. While the exact mode of inheritance is still debated, it is known to be an autosomal recessive disorder.
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This question is part of the following fields:
- Gastrointestinal System
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Question 120
Correct
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A 54-year-old man complains of epigastric discomfort and experiences migratory thrombophlebitis. During examination, he displays mild jaundice. A CT scan reveals a mass in the pancreatic head and peri hilar lymphadenopathy. What is the probable underlying diagnosis?
Your Answer: Adenocarcinoma of the pancreas
Explanation:The most probable diagnosis is adenocarcinoma of the pancreas, which is often accompanied by migratory thrombophlebitis. Squamous cell carcinoma is a rare occurrence in the pancreas.
Pancreatic cancer is a type of cancer that is often diagnosed late due to its non-specific symptoms. The majority of pancreatic tumors are adenocarcinomas and are typically found in the head of the pancreas. Risk factors for pancreatic cancer include increasing age, smoking, diabetes, chronic pancreatitis, hereditary non-polyposis colorectal carcinoma, and mutations in the BRCA2 and KRAS genes.
Symptoms of pancreatic cancer can include painless jaundice, pale stools, dark urine, and pruritus. Courvoisier’s law states that a palpable gallbladder is unlikely to be due to gallstones in the presence of painless obstructive jaundice. However, patients often present with non-specific symptoms such as anorexia, weight loss, and epigastric pain. Loss of exocrine and endocrine function can also occur, leading to steatorrhea and diabetes mellitus. Atypical back pain and migratory thrombophlebitis (Trousseau sign) are also common.
Ultrasound has a sensitivity of around 60-90% for detecting pancreatic cancer, but high-resolution CT scanning is the preferred diagnostic tool. The ‘double duct’ sign, which is the simultaneous dilatation of the common bile and pancreatic ducts, may be seen on imaging.
Less than 20% of patients with pancreatic cancer are suitable for surgery at the time of diagnosis. A Whipple’s resection (pancreaticoduodenectomy) may be performed for resectable lesions in the head of the pancreas, but side-effects such as dumping syndrome and peptic ulcer disease can occur. Adjuvant chemotherapy is typically given following surgery, and ERCP with stenting may be used for palliation.
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This question is part of the following fields:
- Gastrointestinal System
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Question 121
Incorrect
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A passionate surgical resident attempts his first independent splenectomy. The procedure proves to be more challenging than expected and the resident places a tube drain in the splenic bed at the conclusion of the surgery. Within the next 24 hours, around 500ml of clear fluid drains into the tube. What is the most probable result of biochemical testing on the fluid?
Elevated creatinine
28%
Elevated triglycerides
10%
Elevated glucagon
9%
Elevated amylase
25%
None of the above
29%
During a splenectomy, the tail of the pancreas may be harmed, causing the pancreatic duct to drain into the splenic bed, resulting in an increase in amylase levels. Glucagon is not produced in the pancreatic duct.Your Answer: Elevated glucagon
Correct Answer: Elevated amylase
Explanation:If the tail of the pancreas is damaged during splenectomy, the pancreatic duct may end up draining into the splenic bed. This can result in an increase in amylase levels, but there will be no secretion of glucagon into the pancreatic duct.
Understanding the Anatomy of the Spleen
The spleen is a vital organ in the human body, serving as the largest lymphoid organ. It is located below the 9th-12th ribs and has a clenched fist shape. The spleen is an intraperitoneal organ, and its peritoneal attachments condense at the hilum, where the vessels enter the spleen. The blood supply of the spleen is from the splenic artery, which is derived from the coeliac axis, and the splenic vein, which is joined by the IMV and unites with the SMV.
The spleen is derived from mesenchymal tissue during embryology. It weighs between 75-150g and has several relations with other organs. The diaphragm is superior to the spleen, while the gastric impression is anterior, the kidney is posterior, and the colon is inferior. The hilum of the spleen is formed by the tail of the pancreas and splenic vessels. The spleen also forms the apex of the lesser sac, which contains short gastric vessels.
In conclusion, understanding the anatomy of the spleen is crucial in comprehending its functions and the role it plays in the human body. The spleen’s location, weight, and relations with other organs are essential in diagnosing and treating spleen-related conditions.
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This question is part of the following fields:
- Gastrointestinal System
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Question 122
Correct
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A 57-year-old woman comes to the doctor complaining of colicky pain in her right upper quadrant that has been occurring periodically for the past 4 months. She had her worst episode last night after eating takeout, which caused her to vomit due to the severity of the pain.
During the examination, her temperature was found to be 37.7ºC, respiratory rate 14/min, blood pressure 118/75mmHg, and oxygen saturation was 98%. Her abdomen was soft and non-tender, and Murphy's sign was negative.
What is the hormone responsible for her symptoms?Your Answer: Cholecystokinin (CCK)
Explanation:The correct answer is Cholecystokinin (CCK) as the woman is experiencing classic symptoms of biliary colic. CCK is released in response to fatty foods in the duodenum, causing increased gallbladder contraction and resulting in biliary colic.
Gastrin stimulates the secretion of gastric acid in response to stomach distension after a meal.
Prostaglandin causes uterine muscles to contract, leading to the expulsion of the uterine lining during menstruation. However, the patient’s symptoms are more indicative of biliary colic than dysmenorrhea.
Secretin decreases gastric acid secretion and increases pancreatic secretion, but it does not stimulate the gallbladder.
Overview of Gastrointestinal Hormones
Gastrointestinal hormones play a crucial role in the digestion and absorption of food. These hormones are secreted by various cells in the stomach and small intestine in response to different stimuli such as the presence of food, pH changes, and neural signals.
One of the major hormones involved in food digestion is gastrin, which is secreted by G cells in the antrum of the stomach. Gastrin increases acid secretion by gastric parietal cells, stimulates the secretion of pepsinogen and intrinsic factor, and increases gastric motility. Another hormone, cholecystokinin (CCK), is secreted by I cells in the upper small intestine in response to partially digested proteins and triglycerides. CCK increases the secretion of enzyme-rich fluid from the pancreas, contraction of the gallbladder, and relaxation of the sphincter of Oddi. It also decreases gastric emptying and induces satiety.
Secretin is another hormone secreted by S cells in the upper small intestine in response to acidic chyme and fatty acids. Secretin increases the secretion of bicarbonate-rich fluid from the pancreas and hepatic duct cells, decreases gastric acid secretion, and has a trophic effect on pancreatic acinar cells. Vasoactive intestinal peptide (VIP) is a neural hormone that stimulates secretion by the pancreas and intestines and inhibits acid secretion.
Finally, somatostatin is secreted by D cells in the pancreas and stomach in response to fat, bile salts, and glucose in the intestinal lumen. Somatostatin decreases acid and pepsin secretion, decreases gastrin secretion, decreases pancreatic enzyme secretion, and decreases insulin and glucagon secretion. It also inhibits the trophic effects of gastrin and stimulates gastric mucous production.
In summary, gastrointestinal hormones play a crucial role in regulating the digestive process and maintaining homeostasis in the gastrointestinal tract.
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This question is part of the following fields:
- Gastrointestinal System
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Question 123
Correct
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A 12-year-old boy presents to the emergency department with complaints of central abdominal pain that has shifted to the right iliac fossa. Upon examination, there are no indications of rebound tenderness or guarding.
What is the most probable diagnosis, and how would you describe the pathophysiology of the condition?Your Answer: Obstruction of the appendiceal lumen due to lymphoid hyperplasia or faecolith
Explanation:The pathophysiology of appendicitis involves obstruction of the appendiceal lumen, which is commonly caused by lymphoid hyperplasia or a faecolith. This condition is most prevalent in young individuals aged 10-20 years and is the most common acute abdominal condition requiring surgery. Blood clots are not a typical cause of appendiceal obstruction, but foreign bodies and worms can also contribute to this condition.
Pancreatitis can lead to autodigestion in the pancreas, while autoimmune destruction of the pancreas is responsible for type 1 diabetes. Symptoms of type 1 diabetes, which typically develops at a younger age than type 2 diabetes, include polydipsia and polyuria.
Acute appendicitis is a common condition that requires surgery and can occur at any age, but is most prevalent in young people aged 10-20 years. The pathogenesis of acute appendicitis involves lymphoid hyperplasia or a faecolith, which leads to obstruction of the appendiceal lumen. This obstruction causes gut organisms to invade the appendix wall, resulting in oedema, ischaemia, and possibly perforation.
The most common symptom of acute appendicitis is abdominal pain, which is typically peri-umbilical and radiates to the right iliac fossa due to localised peritoneal inflammation. Other symptoms include mild pyrexia, anorexia, and nausea. Examination may reveal generalised or localised peritonism, rebound and percussion tenderness, guarding and rigidity, and classical signs such as Rovsing’s sign and psoas sign.
Diagnosis of acute appendicitis is typically based on raised inflammatory markers and compatible history and examination findings. Imaging may be used in certain cases, such as ultrasound in females where pelvic organ pathology is suspected. Management of acute appendicitis involves appendicectomy, which can be performed via an open or laparoscopic approach. Patients with perforated appendicitis require copious abdominal lavage, while those without peritonitis who have an appendix mass should receive broad-spectrum antibiotics and consideration given to performing an interval appendicectomy. Intravenous antibiotics alone have been trialled as a treatment for appendicitis, but evidence suggests that this is associated with a longer hospital stay and up to 20% of patients go on to have an appendicectomy within 12 months.
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This question is part of the following fields:
- Gastrointestinal System
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Question 124
Correct
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A 60-year-old woman presents to her physician complaining of upper abdominal pain, fatigue, and unintentional weight loss over the past 4 months. During the physical examination, a mass is palpated in the epigastric region. The doctor suspects gastric cancer and refers the patient for an endoscopy. What type of cell would confirm the diagnosis?
Your Answer: Signet ring
Explanation:The patient is diagnosed with gastric adenocarcinoma, which is a type of cancer that originates in the stomach lining. The presence of signet ring cells in the biopsy is a concerning feature, indicating an aggressive form of adenocarcinoma.
Chief cells are normal cells found in the stomach lining and are not indicative of any pathology in this case.
Megaloblast cells are abnormally large red blood cells that are not expected to be present in a gastric biopsy. They are typically associated with conditions such as leukaemia.
Merkel cells are benign cells found in the skin that play a role in the sensation of touch.
Mucous cells are normal cells found in the stomach lining that produce mucus.
Gastric cancer is a relatively uncommon type of cancer, accounting for only 2% of all cancer diagnoses in developed countries. It is more prevalent in older individuals, with half of patients being over the age of 75, and is more common in males than females. Several risk factors have been identified, including Helicobacter pylori infection, atrophic gastritis, certain dietary habits, smoking, and blood group. Symptoms of gastric cancer can include abdominal pain, weight loss, nausea, vomiting, and dysphagia. In some cases, lymphatic spread may result in the appearance of nodules in the left supraclavicular lymph node or periumbilical area. Diagnosis is typically made through oesophago-gastro-duodenoscopy with biopsy, and staging is done using CT. Treatment options depend on the extent and location of the cancer and may include endoscopic mucosal resection, partial or total gastrectomy, and chemotherapy.
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This question is part of the following fields:
- Gastrointestinal System
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Question 125
Correct
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A 57-year-old man is having a pancreatectomy for cancer. While removing the gland, which structure will the surgeon not come across behind the pancreas?
Your Answer: Gastroduodenal artery
Explanation:At the superior part of the pancreas, the gastroduodenal artery splits into the pancreaticoduodenal and gastro-epiploic arteries.
Anatomy of the Pancreas
The pancreas is located behind the stomach and is a retroperitoneal organ. It can be accessed surgically by dividing the peritoneal reflection that connects the greater omentum to the transverse colon. The pancreatic head is situated in the curvature of the duodenum, while its tail is close to the hilum of the spleen. The pancreas has various relations with other organs, such as the inferior vena cava, common bile duct, renal veins, superior mesenteric vein and artery, crus of diaphragm, psoas muscle, adrenal gland, kidney, aorta, pylorus, gastroduodenal artery, and splenic hilum.
The arterial supply of the pancreas is through the pancreaticoduodenal artery for the head and the splenic artery for the rest of the organ. The venous drainage for the head is through the superior mesenteric vein, while the body and tail are drained by the splenic vein. The ampulla of Vater is an important landmark that marks the transition from foregut to midgut and is located halfway along the second part of the duodenum. Overall, understanding the anatomy of the pancreas is crucial for surgical procedures and diagnosing pancreatic diseases.
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This question is part of the following fields:
- Gastrointestinal System
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Question 126
Correct
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A 50-year-old woman visits her doctor with worries about experiencing dark, tarry stools for the past 4 days. She has a medical history of hypertension, which is well controlled with ramipril. Apart from ibuprofen, which she is taking for a recent skiing injury, she is not on any other regular medication. She casually mentions that she has lost some weight but denies having any abdominal pain. She is a non-smoker and drinks approximately 17 units of alcohol per week. On examination, there are no signs of chronic liver disease, but her conjunctiva appears pale. The doctor is concerned and decides to conduct several blood tests.
Hb 10.1 g/l
Platelets 202 * 109/l
WBC 9.2 * 109/l
Na+ 137 mmol/l
K+ 4.1 mmol/l
Urea 34 mmol/l
Creatinine 105 µmol/l
What is the most probable reason for the patient's symptoms?Your Answer: Peptic ulcer
Explanation:An upper gastrointestinal (GI) bleed can lead to the formation of melaena, which is characterized by the passage of dark and tarry stool through the digestive tract. Peptic ulcer is a frequent cause of upper GI bleed, particularly in patients who have identifiable risk factors such as the use of NSAIDs, as seen in this patient.
The blood tests reveal an elevated urea level without an increase in creatinine, which is a typical presentation in an upper GI bleed. Additionally, the presence of anemia is also suggestive of a bleed.
Acute upper gastrointestinal bleeding is a common and significant medical issue that can be caused by various conditions, with oesophageal varices and peptic ulcer disease being the most common. The main symptoms include haematemesis (vomiting of blood), melena (passage of altered blood per rectum), and a raised urea level due to the protein meal of the blood. The diagnosis can be determined by identifying the specific features associated with a particular condition, such as stigmata of chronic liver disease for oesophageal varices or abdominal pain for peptic ulcer disease.
The differential diagnosis for acute upper gastrointestinal bleeding includes oesophageal, gastric, and duodenal causes. Oesophageal varices may present with a large volume of fresh blood, while gastric ulcers may cause low volume bleeds that present as iron deficiency anaemia. Duodenal ulcers are usually posteriorly sited and may erode the gastroduodenal artery. Aorto-enteric fistula is a rare but important cause of major haemorrhage associated with high mortality in patients with previous abdominal aortic aneurysm surgery.
The management of acute upper gastrointestinal bleeding involves risk assessment using the Glasgow-Blatchford score, which helps clinicians decide whether patients can be managed as outpatients or not. Resuscitation involves ABC, wide-bore intravenous access, and platelet transfusion if actively bleeding platelet count is less than 50 x 10*9/litre. Endoscopy should be offered immediately after resuscitation in patients with a severe bleed, and all patients should have endoscopy within 24 hours. Treatment options include repeat endoscopy, interventional radiology, and surgery for non-variceal bleeding, while terlipressin and prophylactic antibiotics should be given to patients with variceal bleeding. Band ligation should be used for oesophageal varices, and injections of N-butyl-2-cyanoacrylate for patients with gastric varices. Transjugular intrahepatic portosystemic shunts (TIPS) should be offered if bleeding from varices is not controlled with the above measures.
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This question is part of the following fields:
- Gastrointestinal System
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Question 127
Incorrect
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A 65-year-old male patient is referred to the upper GI clinic under the two-week rule. His daughter first noticed that his skin and eyes are becoming yellow. His past medical history includes neurofibromatosis type 1. He was recently diagnosed with Type 2 diabetes mellitus however the blood glucose has been very poorly controlled despite maximum therapy of metformin and gliclazide. On examination, he is jaundiced. There is mild discomfort in the epigastric region and the right upper quadrant. An urgent abdominal CT scan shows a mass arising from the head of the pancreas and dilated common bile duct. A subsequent endoscopic retrograde cholangiopancreatography (ERCP) and biopsy confirms a pancreatic somatostatinoma.
From which cells in the pancreas is this tumour originating?Your Answer: I cells
Correct Answer: D cells
Explanation:Overview of Gastrointestinal Hormones
Gastrointestinal hormones play a crucial role in the digestion and absorption of food. These hormones are secreted by various cells in the stomach and small intestine in response to different stimuli such as the presence of food, pH changes, and neural signals.
One of the major hormones involved in food digestion is gastrin, which is secreted by G cells in the antrum of the stomach. Gastrin increases acid secretion by gastric parietal cells, stimulates the secretion of pepsinogen and intrinsic factor, and increases gastric motility. Another hormone, cholecystokinin (CCK), is secreted by I cells in the upper small intestine in response to partially digested proteins and triglycerides. CCK increases the secretion of enzyme-rich fluid from the pancreas, contraction of the gallbladder, and relaxation of the sphincter of Oddi. It also decreases gastric emptying and induces satiety.
Secretin is another hormone secreted by S cells in the upper small intestine in response to acidic chyme and fatty acids. Secretin increases the secretion of bicarbonate-rich fluid from the pancreas and hepatic duct cells, decreases gastric acid secretion, and has a trophic effect on pancreatic acinar cells. Vasoactive intestinal peptide (VIP) is a neural hormone that stimulates secretion by the pancreas and intestines and inhibits acid secretion.
Finally, somatostatin is secreted by D cells in the pancreas and stomach in response to fat, bile salts, and glucose in the intestinal lumen. Somatostatin decreases acid and pepsin secretion, decreases gastrin secretion, decreases pancreatic enzyme secretion, and decreases insulin and glucagon secretion. It also inhibits the trophic effects of gastrin and stimulates gastric mucous production.
In summary, gastrointestinal hormones play a crucial role in regulating the digestive process and maintaining homeostasis in the gastrointestinal tract.
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This question is part of the following fields:
- Gastrointestinal System
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Question 128
Correct
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A 30-year-old man needs a urethral catheter before his splenectomy. At what point will the catheter encounter its first resistance during insertion?
Your Answer: Membranous urethra
Explanation:The external sphincter surrounding the membranous urethra causes it to be the least distensible part of the urethra.
Urethral Anatomy: Differences Between Male and Female
The anatomy of the urethra differs between males and females. In females, the urethra is shorter and more angled than in males. It is located outside of the peritoneum and is surrounded by the endopelvic fascia. The neck of the bladder is subject to intra-abdominal pressure, and any weakness in this area can lead to stress urinary incontinence. The female urethra is surrounded by the external urethral sphincter, which is innervated by the pudendal nerve. It is located in front of the vaginal opening.
In males, the urethra is much longer and is divided into four parts. The pre-prostatic urethra is very short and lies between the bladder and prostate gland. The prostatic urethra is wider than the membranous urethra and contains several openings for the transmission of semen. The membranous urethra is the narrowest part of the urethra and is surrounded by the external sphincter. The penile urethra travels through the corpus spongiosum on the underside of the penis and is the longest segment of the urethra. The bulbo-urethral glands open into the spongiose section of the urethra.
The urothelium, which lines the inside of the urethra, is transitional near the bladder and becomes squamous further down the urethra. Understanding the differences in urethral anatomy between males and females is important for diagnosing and treating urological conditions.
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This question is part of the following fields:
- Gastrointestinal System
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Question 129
Incorrect
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A 50-year-old man returns from a trip to Asia where he indulged in the local seafood. He now presents with severe 'rice water' diarrhoea, reduced appetite, and low oral intake. Despite this, there is no change in the amount of diarrhoea. He also experiences low-grade fevers, vomiting, and watery diarrhoea for two weeks. He is admitted to the infectious diseases department of his local hospital for further evaluation. The stool osmolar gap is normal, and there are no detectable fat, white blood cells (WBCs), or red blood cells (RBCs) in the faeces. What type of diarrhoea is most likely affecting this patient?
Your Answer: Osmotic diarrhoea
Correct Answer: Secretory diarrhoea
Explanation:Secretory diarrhoea is characterized by a change in the gut from an absorptive state to a secretory state, often caused by toxins or secretagogues. Chronic diarrhoea is usually caused by an underlying condition and can be classified into three subtypes: secretory, osmotic, and inflammatory. Secretory diarrhoea is characterized by large daily stool volumes and can occur even during fasting or sleep due to disrupted ion channels in the gastrointestinal tract. Osmotic diarrhoea is caused by something in the gut forcing water back into the lumen, often seen in malabsorption. Inflammatory diarrhoea is caused by inflammation of the bowel wall, either from medical disease or invasive organisms. Acute infectious diarrhoea can be invasive or enterotoxic/non-invasive, with the former presenting with bloody stool, leukocytosis, and fever, and the latter presenting with a watery stool and lacking systemic symptoms. In either case, WBCs can be detected in the stool.
Understanding Diarrhoea: Causes and Characteristics
Diarrhoea is defined as having more than three loose or watery stools per day. It can be classified as acute if it lasts for less than 14 days and chronic if it persists for more than 14 days. Gastroenteritis, diverticulitis, and antibiotic therapy are common causes of acute diarrhoea. On the other hand, irritable bowel syndrome, ulcerative colitis, Crohn’s disease, colorectal cancer, and coeliac disease are some of the conditions that can cause chronic diarrhoea.
Symptoms of gastroenteritis may include abdominal pain, nausea, and vomiting. Diverticulitis is characterized by left lower quadrant pain, diarrhoea, and fever. Antibiotic therapy, especially with broad-spectrum antibiotics, can also cause diarrhoea, including Clostridium difficile infection. Chronic diarrhoea may be caused by irritable bowel syndrome, which is characterized by abdominal pain, bloating, and changes in bowel habits. Ulcerative colitis may cause bloody diarrhoea, crampy abdominal pain, and weight loss. Crohn’s disease may cause crampy abdominal pain, diarrhoea, and malabsorption. Colorectal cancer may cause diarrhoea, rectal bleeding, anaemia, and weight loss. Coeliac disease may cause diarrhoea, abdominal distension, lethargy, and weight loss.
Other conditions associated with diarrhoea include thyrotoxicosis, laxative abuse, appendicitis, and radiation enteritis. It is important to seek medical attention if diarrhoea persists for more than a few days or is accompanied by other symptoms such as fever, severe abdominal pain, or blood in the stool.
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This question is part of the following fields:
- Gastrointestinal System
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Question 130
Correct
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A 35-year-old patient with consistent PR bleeding is diagnosed with Crohn's disease. What is the primary medication used to induce remission of this condition?
Your Answer: Prednisolone
Explanation:To induce remission of Crohn’s disease, glucocorticoids (whether oral, topical or intravenous) are typically the first line of treatment. 5-ASA drugs are considered a second option for inducing remission of IBD. Azathioprine is more commonly used for maintaining remission. Steroids are specifically used to induce remission of Crohn’s disease. Infliximab is particularly effective for treating refractory disease and fistulating Crohn’s.
Crohn’s disease is a type of inflammatory bowel disease that can affect any part of the digestive tract. The National Institute for Health and Care Excellence (NICE) has published guidelines for managing this condition. Patients are advised to quit smoking, as it can worsen Crohn’s disease. While some studies suggest that NSAIDs and the combined oral contraceptive pill may increase the risk of relapse, the evidence is not conclusive.
To induce remission, glucocorticoids are typically used, but budesonide may be an alternative for some patients. Enteral feeding with an elemental diet may also be used, especially in young children or when there are concerns about steroid side effects. Second-line options include 5-ASA drugs, such as mesalazine, and add-on medications like azathioprine or mercaptopurine. Infliximab is useful for refractory disease and fistulating Crohn’s, and metronidazole is often used for isolated peri-anal disease.
Maintaining remission involves stopping smoking and using azathioprine or mercaptopurine as first-line options. Methotrexate is a second-line option. Surgery is eventually required for around 80% of patients with Crohn’s disease, depending on the location and severity of the disease. Complications of Crohn’s disease include small bowel cancer, colorectal cancer, and osteoporosis. Before offering azathioprine or mercaptopurine, it is important to assess thiopurine methyltransferase (TPMT) activity.
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This question is part of the following fields:
- Gastrointestinal System
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Question 131
Correct
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Which statement about peristalsis is true?
Your Answer: Longitudinal smooth muscle propels the food bolus through the oesophagus
Explanation:Peristalsis: The Movement of Food Through the Digestive System
Peristalsis is the process by which food is moved through the digestive system. Circular smooth muscle contracts behind the food bolus, while longitudinal smooth muscle propels the food through the oesophagus. Primary peristalsis spontaneously moves the food from the oesophagus into the stomach, taking about 9 seconds. Secondary peristalsis occurs when food does not enter the stomach, and stretch receptors are stimulated to cause peristalsis.
In the small intestine, peristalsis waves slow to a few seconds and cause a mixture of chyme. In the colon, three main types of peristaltic activity are recognised. Segmentation contractions are localised contractions in which the bolus is subjected to local forces to maximise mucosal absorption. Antiperistaltic contractions towards the ileum are localised reverse peristaltic waves to slow entry into the colon and maximise absorption. Mass movements are migratory peristaltic waves along the entire colon to empty the organ prior to the next ingestion of a food bolus.
Overall, peristalsis is a crucial process in the digestive system that ensures food is moved efficiently through the body.
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This question is part of the following fields:
- Gastrointestinal System
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Question 132
Correct
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A 58-year-old man with a history of multiple emergency department admissions for alcohol-related injuries and admissions under the general medical team for alcohol withdrawal is admitted after a twelve-day drinking binge. He presents with confusion, icterus, and hepatomegaly, with stigmata of chronic liver disease. Upon admission, his blood work shows thrombocytopenia, transaminitis with hyperbilirubinemia, and a severe coagulopathy. The diagnosis is severe acute alcoholic hepatitis. In liver disease-associated coagulopathy, which clotting factor is typically increased?
Your Answer: Factor VIII
Explanation:Coagulopathy in Liver Disease: Paradoxical Supra-normal Factor VIII and Increased Thrombosis Risk
In liver failure, the levels of all clotting factors decrease except for factor VIII, which paradoxically increases. This is because factor VIII is synthesized in endothelial cells throughout the body, unlike other clotting factors that are synthesized only in hepatic endothelial cells. Additionally, good hepatic function is required for the rapid clearance of activated factor VIII from the bloodstream, leading to further increases in circulating factor VIII. Despite conventional coagulation studies suggesting an increased risk of bleeding, patients with chronic liver disease are paradoxically at an increased risk of thrombosis formation. This is due to several factors, including reduced synthesis of natural anticoagulants such as protein C, protein S, and antithrombin, which are all decreased in chronic liver disease.
Reference:
Tripodi et al. An imbalance of pro- vs anticoagulation factors in plasma from patients with cirrhosis. Gastroenterology. 2009 Dec;137(6):2105-11. -
This question is part of the following fields:
- Gastrointestinal System
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Question 133
Correct
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A 28-year-old woman with a three week history of abdominal pain, diarrhoea and weight loss undergoes a colonoscopy. Biopsies are taken and a diagnosis of Crohn's disease is made.
What microscopic changes are expected to be observed in this case?Your Answer: Increased goblet cells
Explanation:Crohn’s disease is characterized by an increase in goblet cells on microscopic examination. Unlike ulcerative colitis, Crohn’s disease may have skip lesions and transmural inflammation. Pseudopolyps and shortening of crypts are more commonly seen in ulcerative colitis.
Inflammatory bowel disease (IBD) is a condition that includes two main types: Crohn’s disease and ulcerative colitis. Although they share many similarities in terms of symptoms, diagnosis, and treatment, there are some key differences between the two. Crohn’s disease is characterized by non-bloody diarrhea, weight loss, upper gastrointestinal symptoms, mouth ulcers, perianal disease, and a palpable abdominal mass in the right iliac fossa. On the other hand, ulcerative colitis is characterized by bloody diarrhea, abdominal pain in the left lower quadrant, tenesmus, gallstones, and primary sclerosing cholangitis. Complications of Crohn’s disease include obstruction, fistula, and colorectal cancer, while ulcerative colitis has a higher risk of colorectal cancer than Crohn’s disease. Pathologically, Crohn’s disease lesions can be seen anywhere from the mouth to anus, while ulcerative colitis inflammation always starts at the rectum and never spreads beyond the ileocaecal valve. Endoscopy and radiology can help diagnose and differentiate between the two types of IBD.
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This question is part of the following fields:
- Gastrointestinal System
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Question 134
Correct
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A 25-year-old female has received a pan proctocolectomy and ileoanal pouch due to familial adenomatous polyposis coli. What is the most frequent non-colonic manifestation of this condition?
Your Answer: Duodenal polyps
Explanation:Polyposis syndromes are a group of genetic disorders that cause the development of multiple polyps in the colon and other parts of the gastrointestinal tract. These polyps can increase the risk of developing cancer, and therefore, early detection and management are crucial. There are several types of polyposis syndromes, each with its own genetic defect, features, and associated disorders.
Familial adenomatous polyposis (FAP) is caused by a mutation in the APC gene and is characterized by the development of over 100 colonic adenomas, with a 100% risk of cancer. Screening and management involve regular colonoscopies and resectional surgery if polyps are found. FAP is also associated with gastric and duodenal polyps and abdominal desmoid tumors.
MYH-associated polyposis is caused by a biallelic mutation of the MYH gene and is associated with multiple colonic polyps and an increased risk of right-sided cancers. Attenuated phenotype can be managed with regular colonoscopies, while resection and ileoanal pouch reconstruction are recommended for those with multiple polyps.
Peutz-Jeghers syndrome is caused by a mutation in the STK11 gene and is characterized by multiple benign intestinal hamartomas, episodic obstruction, and an increased risk of GI cancers. Screening involves annual examinations and pan-intestinal endoscopy every 2-3 years.
Cowden disease is caused by a mutation in the PTEN gene and is characterized by macrocephaly, multiple intestinal hamartomas, and an increased risk of cancer at any site. Targeted individualized screening is recommended, with extra surveillance for breast, thyroid, and uterine cancers.
HNPCC (Lynch syndrome) is caused by germline mutations of DNA mismatch repair genes and is associated with an increased risk of colorectal, endometrial, and gastric cancers. Colonoscopies every 1-2 years from age 25 and consideration of prophylactic surgery are recommended, along with extra colonic surveillance.
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This question is part of the following fields:
- Gastrointestinal System
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Question 135
Correct
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A 36-year-old female patient presents to her GP with complaints of epigastric pain that worsens after consuming takeaways or alcohol. During the consultation, she also reports experiencing a cough at night. The doctor diagnoses her with GORD, which is caused by the irritation of stomach acid (H+) released by cells stimulated by which hormone?
Which cell type is stimulated by gastrin?Your Answer: Gastric parietal cells
Explanation:Gastrin stimulates gastric parietal cells to increase their secretion of H+. The hormone is released by G cells in the stomach and acts on the parietal cells to enhance their production of H+. It is important to note that G cells do not release H+ themselves, but rather release gastrin to stimulate the parietal cells. Other cell types in the stomach, such as gastric chief cells and gastric mucosal cells, have different functions and do not secrete H+ in response to gastrin.
Overview of Gastrointestinal Hormones
Gastrointestinal hormones play a crucial role in the digestion and absorption of food. These hormones are secreted by various cells in the stomach and small intestine in response to different stimuli such as the presence of food, pH changes, and neural signals.
One of the major hormones involved in food digestion is gastrin, which is secreted by G cells in the antrum of the stomach. Gastrin increases acid secretion by gastric parietal cells, stimulates the secretion of pepsinogen and intrinsic factor, and increases gastric motility. Another hormone, cholecystokinin (CCK), is secreted by I cells in the upper small intestine in response to partially digested proteins and triglycerides. CCK increases the secretion of enzyme-rich fluid from the pancreas, contraction of the gallbladder, and relaxation of the sphincter of Oddi. It also decreases gastric emptying and induces satiety.
Secretin is another hormone secreted by S cells in the upper small intestine in response to acidic chyme and fatty acids. Secretin increases the secretion of bicarbonate-rich fluid from the pancreas and hepatic duct cells, decreases gastric acid secretion, and has a trophic effect on pancreatic acinar cells. Vasoactive intestinal peptide (VIP) is a neural hormone that stimulates secretion by the pancreas and intestines and inhibits acid secretion.
Finally, somatostatin is secreted by D cells in the pancreas and stomach in response to fat, bile salts, and glucose in the intestinal lumen. Somatostatin decreases acid and pepsin secretion, decreases gastrin secretion, decreases pancreatic enzyme secretion, and decreases insulin and glucagon secretion. It also inhibits the trophic effects of gastrin and stimulates gastric mucous production.
In summary, gastrointestinal hormones play a crucial role in regulating the digestive process and maintaining homeostasis in the gastrointestinal tract.
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This question is part of the following fields:
- Gastrointestinal System
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Question 136
Correct
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An 83-year-old man visits his GP complaining of weight loss and a change in bowel habit that has been ongoing for the past 6 months. Following a colonoscopy and biopsy, he is diagnosed with a malignancy of the transverse colon. The transverse colon is connected to the posterior abdominal wall by a double fold of the peritoneum. Which other organ is also attached to similar double folds of the peritoneum?
Your Answer: The stomach
Explanation:The mesentery is present in the stomach and the first part of the duodenum as they are intraperitoneal structures.
In the abdomen, organs are categorized as either intraperitoneal or retroperitoneal. The intraperitoneal organs include the stomach, spleen, liver, bulb of the duodenum, jejunum, ileum, transverse colon, and sigmoid colon. The retroperitoneal organs include the remaining part of the duodenum, the cecum and ascending colon, the descending colon, the pancreas, and the kidneys.
The peritoneum has different functions in the abdomen and can be classified accordingly. It is called a mesentery when it anchors organs to the posterior abdominal wall and a ligament when it connects two different organs. The lesser and greater curvatures of the stomach have folds known as the lesser and greater omenta.
The retroperitoneal structures are those that are located behind the peritoneum, which is the membrane that lines the abdominal cavity. These structures include the duodenum (2nd, 3rd, and 4th parts), ascending and descending colon, kidneys, ureters, aorta, and inferior vena cava. They are situated in the back of the abdominal cavity, close to the spine. In contrast, intraperitoneal structures are those that are located within the peritoneal cavity, such as the stomach, duodenum (1st part), jejunum, ileum, transverse colon, and sigmoid colon. It is important to note that the retroperitoneal structures are not well demonstrated in the diagram as the posterior aspect has been removed, but they are still significant in terms of their location and function.
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This question is part of the following fields:
- Gastrointestinal System
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Question 137
Correct
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A 2-year-old child is evaluated for inability to pass stool. After further testing, a rectal biopsy confirms a diagnosis of Hirschsprung's disease.
Can you explain the pathophysiology behind this condition?Your Answer: Failure of the development of the parasympathetic plexuses
Explanation:Hirschsprung’s disease is caused by a failure in the development of the parasympathetic plexuses, which are responsible for allowing the distal part of the large intestine to relax. Without these plexuses, the colon remains tightly sealed, preventing the passage of stool and leading to symptoms such as failure to pass meconium and constipation.
Understanding Hirschsprung’s Disease
Hirschsprung’s disease is a rare condition that affects 1 in 5,000 births. It is caused by a developmental failure of the parasympathetic Auerbach and Meissner plexuses, resulting in an aganglionic segment of bowel. This leads to uncoordinated peristalsis and functional obstruction, which can present as constipation and abdominal distension in older children or failure to pass meconium in the neonatal period.
Hirschsprung’s disease is three times more common in males and is associated with Down’s syndrome. Diagnosis is made through a rectal biopsy, which is considered the gold standard. Treatment involves initial rectal washouts or bowel irrigation, followed by surgery to remove the affected segment of the colon.
In summary, Hirschsprung’s disease is a rare but important differential diagnosis in childhood constipation. Understanding its pathophysiology, associations, possible presentations, and management is crucial for healthcare professionals to provide appropriate care for affected individuals.
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This question is part of the following fields:
- Gastrointestinal System
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Question 138
Correct
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A 29-year-old man contacts his primary care physician with concerns about his skin turning yellow. He reports that this change has been occurring gradually over the past few days and is not accompanied by any pain or other symptoms. Upon further inquiry, the patient discloses that he was recently discharged from the hospital after receiving treatment for pyelonephritis. He denies any recent travel outside of his local area.
The patient's liver function tests reveal the following results:
- Bilirubin: 32 µmol/L (normal range: 3 - 17)
- ALP: 41 u/L (normal range: 30 - 100)
- ALT: 19 u/L (normal range: 3 - 40)
- γGT: 26 u/L (normal range: 8 - 60)
- Albumin: 43 g/L (normal range: 35 - 50)
What is the most likely diagnosis?Your Answer: Gilbert's syndrome
Explanation:The patient’s presentation is consistent with Gilbert’s syndrome, which is characterized by an increase in serum bilirubin during times of physiological stress due to a deficiency in the liver’s ability to process bilirubin. This can be triggered by illness, exercise, or fasting.
Autoimmune hepatitis, on the other hand, typically results in severely abnormal liver function tests with significantly elevated liver enzymes, which is not the case for this patient.
Hepatitis A is often associated with recent foreign travel and is accompanied by symptoms such as abdominal pain and diarrhea.
Mirizzi syndrome is a rare condition in which a gallstone becomes lodged in the biliary tree, causing a blockage of the bile duct. It typically presents with upper right quadrant pain and signs of obstructive jaundice.
While painless jaundice can be a symptom of pancreatic cancer, it is highly unlikely in a 27-year-old patient and is therefore an unlikely diagnosis in this case.
Gilbert’s syndrome is a genetic disorder that affects the way bilirubin is processed in the body. It is caused by a deficiency of UDP glucuronosyltransferase, which leads to unconjugated hyperbilirubinemia. This means that bilirubin is not properly broken down and eliminated from the body, resulting in jaundice. However, jaundice may only be visible during certain conditions such as fasting, exercise, or illness. The prevalence of Gilbert’s syndrome is around 1-2% in the general population.
To diagnose Gilbert’s syndrome, doctors may look for a rise in bilirubin levels after prolonged fasting or the administration of IV nicotinic acid. However, treatment is not necessary for this condition. While the exact mode of inheritance is still debated, it is known to be an autosomal recessive disorder.
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This question is part of the following fields:
- Gastrointestinal System
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Question 139
Correct
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A 28-year-old patient presents with sudden onset of fever and complains of a painful mouth. The patient has a history of inflammatory bowel disease and has recently started taking sulphasalazine. There is no history of recent travel or any other relevant medical history.
What urgent investigation should be performed in this case?Your Answer: Full blood count
Explanation:Aminosalicylates can cause various haematological adverse effects, including agranulocytosis, which can be detected through FBC testing. In this case, the patient’s recent exposure to sulphasalazine and symptoms of fever and mouth ulcers suggest bone marrow suppression with an infection. While an acute flare of IBD is a possible differential diagnosis, it is not strongly supported by the clinical signs. Amylase testing is not likely to be helpful in this case, as the presentation points more towards agranulocytosis than pancreatitis. CRP testing may be performed to monitor inflammation, but it is not likely to provide a specific diagnosis. Total bilirubin testing is included as a reminder of the potential haematological side-effects of aminosalicylates, such as haemolytic anaemia, but it is not a key investigation in this case. FBC testing is the most clinically urgent investigation to support the diagnosis of agranulocytosis.
Aminosalicylate Drugs for Inflammatory Bowel Disease
Aminosalicylate drugs are commonly used to treat inflammatory bowel disease (IBD). These drugs work by releasing 5-aminosalicyclic acid (5-ASA) in the colon, which acts as an anti-inflammatory agent. The exact mechanism of action is not fully understood, but it is believed that 5-ASA may inhibit prostaglandin synthesis.
Sulphasalazine is a combination of sulphapyridine and 5-ASA. However, many of the side effects associated with this drug are due to the sulphapyridine component, such as rashes, oligospermia, headache, Heinz body anaemia, megaloblastic anaemia, and lung fibrosis. Mesalazine is a delayed release form of 5-ASA that avoids the sulphapyridine side effects seen in patients taking sulphasalazine. However, it is still associated with side effects such as gastrointestinal upset, headache, agranulocytosis, pancreatitis, and interstitial nephritis.
Olsalazine is another aminosalicylate drug that consists of two molecules of 5-ASA linked by a diazo bond, which is broken down by colonic bacteria. It is important to note that aminosalicylates are associated with a variety of haematological adverse effects, including agranulocytosis. Therefore, a full blood count is a key investigation in an unwell patient taking these drugs. Pancreatitis is also more common in patients taking mesalazine compared to sulfasalazine.
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This question is part of the following fields:
- Gastrointestinal System
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Question 140
Correct
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A 57-year-old man presents with recurrent episodes of urinary sepsis. He reports experiencing left iliac fossa pain repeatedly over the past few months and has noticed bubbles in his urine. A CT scan reveals a large inflammatory mass in the left iliac fossa, with no other abnormalities detected. What is the most likely diagnosis?
Ulcerative colitis
12%
Crohn's disease
11%
Mesenteric ischemia
11%
Diverticular disease
53%
Rectal cancer
13%
Explanation:
Recurrent diverticulitis can lead to the formation of local abscesses that may erode into the bladder, resulting in urinary sepsis and pneumaturia. This presentation would be atypical for Crohn's disease, and rectal cancer would typically be located more distally, with evidence of extra colonic disease present if the cancer were advanced.Your Answer: Diverticular disease
Explanation:Colovesical fistula is frequently caused by diverticular disease.
Repeated episodes of diverticulitis can lead to the formation of abscesses in the affected area. These abscesses may then erode into the bladder, causing urinary sepsis and pneumaturia. This presentation would be atypical for Crohn’s disease, and rectal cancer typically occurs in a more distal location. Additionally, if the case were malignant, there would likely be evidence of extra colonic disease and advanced progression.
Understanding Diverticular Disease
Diverticular disease is a common condition that involves the protrusion of the colon’s mucosa through its muscular wall. This typically occurs between the taenia coli, where vessels penetrate the muscle to supply the mucosa. Symptoms of diverticular disease include altered bowel habits, rectal bleeding, and abdominal pain. Complications can arise, such as diverticulitis, haemorrhage, fistula development, perforation and faecal peritonitis, abscess formation, and diverticular phlegmon.
To diagnose diverticular disease, patients may undergo a colonoscopy, CT cologram, or barium enema. However, it can be challenging to rule out cancer, especially in diverticular strictures. Acutely unwell surgical patients require a systematic investigation, including plain abdominal films and an erect chest x-ray to identify perforation. An abdominal CT scan with oral and intravenous contrast can help identify acute inflammation and local complications.
Treatment for diverticular disease includes increasing dietary fibre intake and managing mild attacks with antibiotics. Peri colonic abscesses require drainage, either surgically or radiologically. Recurrent episodes of acute diverticulitis requiring hospitalisation may indicate a segmental resection. Hinchey IV perforations, which involve generalised faecal peritonitis, require a resection and usually a stoma. This group has a high risk of postoperative complications and typically requires HDU admission. Less severe perforations may be managed by laparoscopic washout and drain insertion.
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This question is part of the following fields:
- Gastrointestinal System
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Question 141
Correct
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A 50-year-old man arrives at the emergency department with complaints of a high fever and flank pain. He reports experiencing mild burning during urination for the past 5 days, but his urine output has decreased since the onset of fever yesterday. The patient has a history of poorly controlled type II diabetes mellitus.
Based on the probable diagnosis, which structure is at the highest risk of co-infection?Your Answer: Psoas muscle
Explanation:The woman in the scenario is likely suffering from pyelonephritis, which is a result of a UTI. Her poorly controlled blood sugar levels due to diabetes make her more susceptible to recurrent UTIs. Since the kidneys are retroperitoneal organs, the infection can spread to other organs within that space. The psoas muscle, located at the back, can become co-infected with pyelonephritis, leading to the formation of an abscess. The symptoms of a psoas abscess may be minimal, and an MRI abdopelvis is the best imaging technique to detect it. Peritoneal structures are less likely to become infected, and peritonitis is usually caused by infected ascitic fluid, leading to Spontaneous Bacterial Peritonitis (SBP).
The retroperitoneal structures are those that are located behind the peritoneum, which is the membrane that lines the abdominal cavity. These structures include the duodenum (2nd, 3rd, and 4th parts), ascending and descending colon, kidneys, ureters, aorta, and inferior vena cava. They are situated in the back of the abdominal cavity, close to the spine. In contrast, intraperitoneal structures are those that are located within the peritoneal cavity, such as the stomach, duodenum (1st part), jejunum, ileum, transverse colon, and sigmoid colon. It is important to note that the retroperitoneal structures are not well demonstrated in the diagram as the posterior aspect has been removed, but they are still significant in terms of their location and function.
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This question is part of the following fields:
- Gastrointestinal System
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Question 142
Correct
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A 68-year-old man presents with an abdominal aortic aneurysm that causes displacement of the left renal vein. At this level, which branch of the aorta is most likely to be affected?
Your Answer: Superior mesenteric artery
Explanation:The left renal vein is situated posterior to the SMA at its point of origin from the aorta. In cases of juxtarenal AAA, separation of the left renal vein may be necessary, but if the SMA is directly affected, a combination of surgical bypass and endovascular occlusion may be required.
Branches of the Abdominal Aorta
The abdominal aorta is a major blood vessel that supplies oxygenated blood to the abdominal organs and lower extremities. It gives rise to several branches that supply blood to various organs and tissues. These branches can be classified into two types: parietal and visceral.
The parietal branches supply blood to the walls of the abdominal cavity, while the visceral branches supply blood to the abdominal organs. The branches of the abdominal aorta include the inferior phrenic, coeliac, superior mesenteric, middle suprarenal, renal, gonadal, lumbar, inferior mesenteric, median sacral, and common iliac arteries.
The inferior phrenic artery arises from the upper border of the abdominal aorta and supplies blood to the diaphragm. The coeliac artery supplies blood to the liver, stomach, spleen, and pancreas. The superior mesenteric artery supplies blood to the small intestine, cecum, and ascending colon. The middle suprarenal artery supplies blood to the adrenal gland. The renal arteries supply blood to the kidneys. The gonadal arteries supply blood to the testes or ovaries. The lumbar arteries supply blood to the muscles and skin of the back. The inferior mesenteric artery supplies blood to the descending colon, sigmoid colon, and rectum. The median sacral artery supplies blood to the sacrum and coccyx. The common iliac arteries are the terminal branches of the abdominal aorta and supply blood to the pelvis and lower extremities.
Understanding the branches of the abdominal aorta is important for diagnosing and treating various medical conditions that affect the abdominal organs and lower extremities.
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This question is part of the following fields:
- Gastrointestinal System
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Question 143
Correct
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In a patient with a carcinoma of the proximal sigmoid colon, what is the most probable origin of its vascular supply?
Your Answer: Inferior mesenteric artery
Explanation:When performing a high anterior resection for these types of tumors, it is necessary to ligate the inferior mesenteric artery. However, it is important to note that the internal iliac artery’s branches, particularly the middle rectal branch, play a crucial role in preserving blood flow to the rectal stump and ensuring the anastomoses’ integrity.
Anatomy of the Rectum
The rectum is a capacitance organ that measures approximately 12 cm in length. It consists of both intra and extraperitoneal components, with the transition from the sigmoid colon marked by the disappearance of the tenia coli. The extra peritoneal rectum is surrounded by mesorectal fat that contains lymph nodes, which are removed during rectal cancer surgery. The fascial layers that surround the rectum are important clinical landmarks, with the fascia of Denonvilliers located anteriorly and Waldeyers fascia located posteriorly.
In males, the rectum is adjacent to the rectovesical pouch, bladder, prostate, and seminal vesicles, while in females, it is adjacent to the recto-uterine pouch (Douglas), cervix, and vaginal wall. Posteriorly, the rectum is in contact with the sacrum, coccyx, and middle sacral artery, while laterally, it is adjacent to the levator ani and coccygeus muscles.
The superior rectal artery supplies blood to the rectum, while the superior rectal vein drains it. Mesorectal lymph nodes located superior to the dentate line drain into the internal iliac and then para-aortic nodes, while those located inferior to the dentate line drain into the inguinal nodes. Understanding the anatomy of the rectum is crucial for surgical procedures and the diagnosis and treatment of rectal diseases.
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This question is part of the following fields:
- Gastrointestinal System
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Question 144
Correct
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A 45-year-old African American male presents to his physician with complaints of epigastric pain occurring a few hours after eating. He reports experiencing this for several months but denies any weight loss, loss of appetite, or night sweats. He does not smoke or drink alcohol and maintains a healthy diet. He denies excessive use of non-steroidal anti-inflammatory drugs. A Helicobacter pylori stool antigen test comes back negative, and he is prescribed a proton pump inhibitor. After three months, he reports no relief of symptoms and has been experiencing severe diarrhea.
The patient's special laboratory investigations reveal negative stool ova and parasites, with normal levels of sodium, potassium, bicarbonate, and urea. His creatinine levels are within the normal range, but his fasting serum gastrin levels are significantly elevated at 1200 pg/mL (normal range: 0-125). Additionally, his gastric pH is measured at 1.2, which is lower than the normal range of >2.
What is the most likely diagnosis for this patient?Your Answer: Zollinger- Ellison syndrome
Explanation:Zollinger-Ellison syndrome (ZES) is the most likely diagnosis for the patient due to their persistent epigastric pain, diarrhea, and high levels of serum gastrin, which cannot be explained by peptic ulcer disease alone. ZES is caused by a gastrin-secreting tumor in the pancreas or duodenum, and is often associated with MEN 1. Diagnosis is confirmed by elevated serum gastrin levels at least 10 times the upper limit of normal, reduced gastric pH, and a secretin stimulation test if necessary.
Carcinoid syndrome is an incorrect diagnosis as it presents with different symptoms such as diarrhea, wheezing, flushing, and valvular lesions due to serotonin secretion.
Although celiac disease can cause epigastric pain and diarrhea, the elevated gastrin levels make ZES a more likely diagnosis. Celiac disease is diagnosed by measuring levels of anti-TTG and anti-endomysial IgA.
Gastric carcinoma is unlikely as there are no risk factors, constitutional symptoms, or elevated fasting gastrin levels.
H. pylori infection has been ruled out by a negative stool antigen test.
Understanding Zollinger-Ellison Syndrome
Zollinger-Ellison syndrome is a medical condition that is caused by the overproduction of gastrin, which is usually due to a tumor in the pancreas or duodenum. This condition is often associated with MEN type I syndrome, which affects around 30% of cases. The symptoms of Zollinger-Ellison syndrome include multiple gastroduodenal ulcers, diarrhea, and malabsorption.
To diagnose Zollinger-Ellison syndrome, doctors typically perform a fasting gastrin level test, which is considered the best screening test. Additionally, a secretin stimulation test may also be performed to confirm the diagnosis. With early diagnosis and treatment, the symptoms of Zollinger-Ellison syndrome can be managed effectively.
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This question is part of the following fields:
- Gastrointestinal System
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Question 145
Correct
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Mrs. Smith is a 75-year-old woman who has been admitted with pneumonia. She is frail and receiving antibiotics and fluids intravenously. She has no appetite and a Speech And Language Therapy (SALT) review concludes she is at risk of aspiration.
Her past medical history includes hypertension and angina.
What would be the most appropriate nutritional support option for Mrs. Smith?Your Answer: Nasogastric tube (NG tube)
Explanation:NICE Guidelines for Parenteral Nutrition
Parenteral nutrition is a method of feeding that involves delivering nutrients directly into the bloodstream through a vein. The National Institute for Health and Care Excellence (NICE) has provided guidelines for the use of parenteral nutrition in patients who are malnourished or at risk of malnutrition.
To identify patients who are malnourished, healthcare professionals should look for a BMI of less than 18.5 kg/m2, unintentional weight loss of more than 10% over 3-6 months, or a BMI of less than 20 kg/m2 with unintentional weight loss of more than 5% over 3-6 months. Patients who have eaten little or nothing for more than 5 days, have poor absorptive capacity, high nutrient losses, or high metabolism are also at risk of malnutrition.
If a patient has unsafe or inadequate oral intake or a non-functional gastrointestinal tract, perforation, or inaccessible GI tract, healthcare professionals should consider parenteral nutrition. For feeding periods of less than 14 days, feeding via a peripheral venous catheter is recommended. For feeding periods of more than 30 days, a tunneled subclavian line is recommended. Continuous administration is recommended for severely unwell patients, but if feed is needed for more than 2 weeks, healthcare professionals should consider changing from continuous to cyclical feeding. In the first 24-48 hours, no more than 50% of the daily regime should be given to unwell patients.
For surgical patients who are malnourished with an unsafe swallow or non-functional GI tract, perforation, or inaccessible GI tract, perioperative parenteral feeding should be considered.
Overall, these guidelines provide healthcare professionals with a framework for identifying patients who may benefit from parenteral nutrition and the appropriate methods for administering it.
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This question is part of the following fields:
- Gastrointestinal System
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Question 146
Correct
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A 30-year-old male is diagnosed with carcinoid syndrome. What hormone is secreted by carcinoids?
Your Answer: Serotonin
Explanation:The rule of thirds for carcinoids is that one-third of cases involve multiple tumors, one-third affect the small bowel, and one-third result in metastasis or the development of a second tumor. It is important to note that carcinoids secrete serotonin, and carcinoid syndrome only occurs when there are liver metastases present, as the liver typically metabolizes the hormone released from primary lesions.
Carcinoid tumours are a type of cancer that can cause a condition called carcinoid syndrome. This syndrome typically occurs when the cancer has spread to the liver and releases serotonin into the bloodstream. In some cases, it can also occur with lung carcinoid tumours, as the mediators are not cleared by the liver. The earliest symptom of carcinoid syndrome is often flushing, but it can also cause diarrhoea, bronchospasm, hypotension, and right heart valvular stenosis (or left heart involvement in bronchial carcinoid). Additionally, other molecules such as ACTH and GHRH may be secreted, leading to conditions like Cushing’s syndrome. Pellagra, a rare condition caused by a deficiency in niacin, can also develop as the tumour diverts dietary tryptophan to serotonin.
To investigate carcinoid syndrome, doctors may perform a urinary 5-HIAA test or a plasma chromogranin A test. Treatment for the condition typically involves somatostatin analogues like octreotide, which can help manage symptoms like diarrhoea. Cyproheptadine may also be used to alleviate diarrhoea. Overall, early detection and treatment of carcinoid tumours can help prevent the development of carcinoid syndrome and improve outcomes for patients.
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This question is part of the following fields:
- Gastrointestinal System
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Question 147
Correct
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Samantha is an 80-year-old woman who has been experiencing painless obstructive jaundice. Upon investigation, a malignancy is discovered. The surgeon recommends a Whipple's procedure to remove the malignancy.
What type of malignancy is the most probable diagnosis?Your Answer: Adenocarcinoma
Explanation:Ductal adenocarcinoma is the most frequently occurring type of pancreatic cancer, particularly in the head of the pancreas. Endocrine tumors of the pancreas are uncommon.
Pancreatic cancer is a type of cancer that is often diagnosed late due to its non-specific symptoms. The majority of pancreatic tumors are adenocarcinomas and are typically found in the head of the pancreas. Risk factors for pancreatic cancer include increasing age, smoking, diabetes, chronic pancreatitis, hereditary non-polyposis colorectal carcinoma, and mutations in the BRCA2 and KRAS genes.
Symptoms of pancreatic cancer can include painless jaundice, pale stools, dark urine, and pruritus. Courvoisier’s law states that a palpable gallbladder is unlikely to be due to gallstones in the presence of painless obstructive jaundice. However, patients often present with non-specific symptoms such as anorexia, weight loss, and epigastric pain. Loss of exocrine and endocrine function can also occur, leading to steatorrhea and diabetes mellitus. Atypical back pain and migratory thrombophlebitis (Trousseau sign) are also common.
Ultrasound has a sensitivity of around 60-90% for detecting pancreatic cancer, but high-resolution CT scanning is the preferred diagnostic tool. The ‘double duct’ sign, which is the simultaneous dilatation of the common bile and pancreatic ducts, may be seen on imaging.
Less than 20% of patients with pancreatic cancer are suitable for surgery at the time of diagnosis. A Whipple’s resection (pancreaticoduodenectomy) may be performed for resectable lesions in the head of the pancreas, but side-effects such as dumping syndrome and peptic ulcer disease can occur. Adjuvant chemotherapy is typically given following surgery, and ERCP with stenting may be used for palliation.
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This question is part of the following fields:
- Gastrointestinal System
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Question 148
Correct
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A 32-year-old man is having surgery to remove his appendix. During the procedure, the external oblique aponeurosis is cut and the underlying muscle is split along its fibers. A strong fibrous structure is found at the medial edge of the incision. What is the most likely structure that will be encountered upon entering this fibrous structure?
Your Answer: Rectus abdominis
Explanation:Upon entry, the structure encountered will be the rectus abdominis muscle, which is surrounded by the rectus sheath.
Abdominal Incisions: Types and Techniques
Abdominal incisions are surgical procedures that involve making an opening in the abdominal wall to access the organs inside. The most common approach is the midline incision, which involves dividing the linea alba, transversalis fascia, extraperitoneal fat, and peritoneum. Another type is the paramedian incision, which is parallel to the midline and involves dividing the anterior rectus sheath, rectus, posterior rectus sheath, transversalis fascia, extraperitoneal fat, and peritoneum. The battle incision is similar to the paramedian but involves displacing the rectus medially.
Other types of abdominal incisions include Kocher’s incision under the right subcostal margin for cholecystectomy, Lanz incision in the right iliac fossa for appendicectomy, gridiron oblique incision centered over McBurney’s point for appendicectomy, Pfannenstiel’s transverse supra-pubic incision primarily used to access pelvic organs, McEvedy’s groin incision for emergency repair of a strangulated femoral hernia, and Rutherford Morrison extraperitoneal approach to the left or right lower quadrants for access to iliac vessels and renal transplantation.
Each type of incision has its own advantages and disadvantages, and the choice of incision depends on the specific surgical procedure and the surgeon’s preference. Proper closure of the incision is crucial to prevent complications such as infection and hernia formation. Overall, abdominal incisions are important techniques in surgical practice that allow for safe and effective access to the abdominal organs.
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This question is part of the following fields:
- Gastrointestinal System
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Question 149
Correct
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A 65-year-old man presents to the emergency department with left-sided abdominal pain and rectal bleeding. He has a past medical history of atrial fibrillation and is on apixaban. He does not smoke cigarettes or drink alcohol.
His observations are heart rate 111 beats per minute, blood pressure 101/58 mmHg, respiratory rate 18/minute, oxygen saturation 96% on room air and temperature 37.8ºC.
Abdominal examination reveals tenderness in the left lower quadrant. Bowel sounds are sluggish. Rectal examination demonstrates a small amount of fresh red blood but no mass lesions, haemorrhoids or fissures. His pulse is irregular. Chest auscultation is normal.
An ECG demonstrates atrial fibrillation.
Blood tests:
Hb 133 g/L Male: (135-180)
Female: (115 - 160)
Platelets 444 * 109/L (150 - 400)
WBC 18.1 * 109/L (4.0 - 11.0)
Na+ 131 mmol/L (135 - 145)
K+ 4.6 mmol/L (3.5 - 5.0)
Urea 8.2 mmol/L (2.0 - 7.0)
Creatinine 130 µmol/L (55 - 120)
CRP 32 mg/L (< 5)
Lactate 2.6 mmol/L (0.0-2.0)
Based on the presumed diagnosis, what is the likely location of the pathology?Your Answer: Splenic flexure
Explanation:Ischaemic colitis most frequently affects the splenic flexure.
Understanding Ischaemic Colitis
Ischaemic colitis is a condition that occurs when there is a temporary reduction in blood flow to the large bowel. This can cause inflammation, ulcers, and bleeding. The condition is more likely to occur in areas of the bowel that are located at the borders of the territory supplied by the superior and inferior mesenteric arteries, such as the splenic flexure.
When investigating ischaemic colitis, doctors may look for a sign called thumbprinting on an abdominal x-ray. This occurs due to mucosal edema and hemorrhage. It is important to diagnose and treat ischaemic colitis promptly to prevent complications and ensure a full recovery.
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This question is part of the following fields:
- Gastrointestinal System
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Question 150
Incorrect
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A 63-year-old man is undergoing a left hemicolectomy for carcinoma of the descending colon. During mobilisation of the left colon, the registrar notices blood in the left paracolic gutter. What is the most likely source of bleeding in this scenario?
Your Answer: Left renal vein
Correct Answer: Spleen
Explanation:Traction injuries during colonic surgery often result in spleen tears, while bleeding from other structures would not be visible in the paracolic gutter before incision of the paracolonic peritoneal edge.
Anatomy of the Left Colon
The left colon is a part of the large intestine that passes inferiorly and becomes extraperitoneal in its posterior aspect. It is closely related to the ureter and gonadal vessels, which may be affected by disease processes. At a certain level, the left colon becomes the sigmoid colon, which is wholly intraperitoneal once again. The sigmoid colon is highly mobile and may even be found on the right side of the abdomen. As it passes towards the midline, the taenia blend marks the transition between the sigmoid colon and upper rectum.
The blood supply of the left colon comes from the inferior mesenteric artery. However, the marginal artery, which comes from the right colon, also contributes significantly. This contribution becomes clinically significant when the inferior mesenteric artery is divided surgically, such as during an abdominal aortic aneurysm repair. Understanding the anatomy of the left colon is important for diagnosing and treating diseases that affect this part of the large intestine.
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This question is part of the following fields:
- Gastrointestinal System
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Question 151
Correct
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A 49-year-old woman comes to the Emergency Department complaining of colicky abdominal pain. She states that she has been having on-and-off pain in the upper right quadrant for the past few months, especially after consuming fatty foods.
Which cells are accountable for generating the hormone linked to this presentation?Your Answer: I cells
Explanation:The correct answer is I cells, which are located in the upper small intestine. This patient’s symptoms are consistent with biliary colic, which occurs when the gallbladder contracts against an obstruction, typically a gallstone. Fatty foods stimulate the production of cholecystokinin (CCK) from the I cells in the duodenum, which promotes gallbladder contractility and the release of bile into the small intestine to aid in lipid emulsification.
B cells are not involved in promoting gallbladder contractility and are instead part of the adaptive immune response. D cells release somatostatin, which decreases insulin production, and are found in the stomach, small intestine, and pancreas. G cells are located in the stomach and secrete gastrin to promote acid secretion by the parietal cells of the stomach.
Overview of Gastrointestinal Hormones
Gastrointestinal hormones play a crucial role in the digestion and absorption of food. These hormones are secreted by various cells in the stomach and small intestine in response to different stimuli such as the presence of food, pH changes, and neural signals.
One of the major hormones involved in food digestion is gastrin, which is secreted by G cells in the antrum of the stomach. Gastrin increases acid secretion by gastric parietal cells, stimulates the secretion of pepsinogen and intrinsic factor, and increases gastric motility. Another hormone, cholecystokinin (CCK), is secreted by I cells in the upper small intestine in response to partially digested proteins and triglycerides. CCK increases the secretion of enzyme-rich fluid from the pancreas, contraction of the gallbladder, and relaxation of the sphincter of Oddi. It also decreases gastric emptying and induces satiety.
Secretin is another hormone secreted by S cells in the upper small intestine in response to acidic chyme and fatty acids. Secretin increases the secretion of bicarbonate-rich fluid from the pancreas and hepatic duct cells, decreases gastric acid secretion, and has a trophic effect on pancreatic acinar cells. Vasoactive intestinal peptide (VIP) is a neural hormone that stimulates secretion by the pancreas and intestines and inhibits acid secretion.
Finally, somatostatin is secreted by D cells in the pancreas and stomach in response to fat, bile salts, and glucose in the intestinal lumen. Somatostatin decreases acid and pepsin secretion, decreases gastrin secretion, decreases pancreatic enzyme secretion, and decreases insulin and glucagon secretion. It also inhibits the trophic effects of gastrin and stimulates gastric mucous production.
In summary, gastrointestinal hormones play a crucial role in regulating the digestive process and maintaining homeostasis in the gastrointestinal tract.
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This question is part of the following fields:
- Gastrointestinal System
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Question 152
Correct
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A man in his early 50s arrives at the Emergency Department complaining of abdominal pain and haematemesis. Upon diagnosis, he is found to have a peptic ulcer. During his treatment, he reveals that he has been taking ibuprofen for several years. His physician informs him that this may have caused the bleeding and recommends taking omeprazole, a gastroprotective medication, in addition to his ibuprofen to lower his chances of recurrence. What is the mechanism of action of omeprazole?
Your Answer: Gastric parietal cell H+/K+-ATPase inhibition
Explanation:The irreversible blockade of H+/K+ ATPase is caused by PPIs.
Parietal cells contain H+/K+-ATPase, which is inhibited by omeprazole, a proton pump inhibitor. Therefore, any answer indicating chief cells or H+/K+-ATPase stimulation is incorrect and potentially harmful.
Ranitidine is an example of a different class of gastroprotective drugs that inhibits H2 receptors.
Understanding Proton Pump Inhibitors
Proton pump inhibitors (PPIs) are medications that work by blocking the H+/K+ ATPase in the stomach’s parietal cells. This action is irreversible and helps to reduce the amount of acid produced in the stomach. Examples of PPIs include omeprazole and lansoprazole.
Despite their effectiveness in treating conditions such as gastroesophageal reflux disease (GERD) and peptic ulcers, PPIs can have adverse effects. These include hyponatremia and hypomagnesemia, which are low levels of sodium and magnesium in the blood, respectively. Prolonged use of PPIs can also increase the risk of osteoporosis, leading to an increased risk of fractures. Additionally, there is a potential for microscopic colitis and an increased risk of C. difficile infections.
It is important to weigh the benefits and risks of PPIs with your healthcare provider and to use them only as directed. Regular monitoring of electrolyte levels and bone density may also be necessary for those on long-term PPI therapy.
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This question is part of the following fields:
- Gastrointestinal System
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Question 153
Correct
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A 45-year-old man presents to the surgical team with abdominal pain, bloating, and vomiting. Based on an abdominal x-ray, there is suspicion of a malignancy causing intestinal obstruction. Which of the following antiemetics should be avoided for managing the patient's vomiting?
Your Answer: Metoclopramide
Explanation:It is not recommended to use metoclopramide as an antiemetic in cases of bowel obstruction. This is because metoclopramide works by blocking dopamine receptors and stimulating peripheral 5HT3 receptors, which promote gastric emptying. However, in cases of intestinal obstruction, gastric emptying is not possible and this effect can be harmful. The choice of antiemetic should be based on the patient’s individual needs and the underlying cause of their nausea.
Understanding the Mechanism and Uses of Metoclopramide
Metoclopramide is a medication primarily used to manage nausea, but it also has other uses such as treating gastro-oesophageal reflux disease and gastroparesis secondary to diabetic neuropathy. It is often combined with analgesics for the treatment of migraines. However, it is important to note that metoclopramide has adverse effects such as extrapyramidal effects, acute dystonia, diarrhoea, hyperprolactinaemia, tardive dyskinesia, and parkinsonism. It should also be avoided in bowel obstruction but may be helpful in paralytic ileus.
The mechanism of action of metoclopramide is quite complicated. It is primarily a D2 receptor antagonist, but it also has mixed 5-HT3 receptor antagonist/5-HT4 receptor agonist activity. Its antiemetic action is due to its antagonist activity at D2 receptors in the chemoreceptor trigger zone, and at higher doses, the 5-HT3 receptor antagonist also has an effect. The gastroprokinetic activity is mediated by D2 receptor antagonist activity and 5-HT4 receptor agonist activity.
In summary, metoclopramide is a medication with multiple uses, but it also has adverse effects that should be considered. Its mechanism of action is complex, involving both D2 receptor antagonist and 5-HT3 receptor antagonist/5-HT4 receptor agonist activity. Understanding the uses and mechanism of action of metoclopramide is important for its safe and effective use.
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This question is part of the following fields:
- Gastrointestinal System
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Question 154
Correct
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A 4-day old neonate with Down's syndrome is experiencing excessive vomiting during their stay in the ward. The mother had an uncomplicated full-term pregnancy. The baby has not yet had their first bowel movement, causing increased concern for the parents. Upon examination, there is slight abdominal distension. Where is the site of pathology within the colon?
Your Answer: Muscularis propria externa
Explanation:The myenteric nerve plexus, also known as Auerbach’s plexus, is located within the muscularis externa, which is one of the four layers of the bowel. In neonates with Hirschsprung disease, there is a lack of ganglion cells in the myenteric plexus, resulting in a lack of peristalsis and symptoms such as nausea, vomiting, bloating, and delayed passage of meconium. This condition is more common in males and children with Down’s syndrome.
The four layers of the bowel, from deep to superficial, are the mucosa, submucosa, muscularis propria (externa), and serosa. The muscularis externa contains two layers of smooth muscle, the inner circular layer and the outer longitudinal layer, with the myenteric plexus located between them. The mucosa also contains a thin layer of connective tissue called the lamina propria.
Layers of the Gastrointestinal Tract and Their Functions
The gastrointestinal (GI) tract is composed of four layers, each with its own unique function. The innermost layer is the mucosa, which can be further divided into three sublayers: the epithelium, lamina propria, and muscularis mucosae. The epithelium is responsible for absorbing nutrients and secreting mucus, while the lamina propria contains blood vessels and immune cells. The muscularis mucosae helps to move food along the GI tract.
The submucosa is the layer that lies beneath the mucosa and contains Meissner’s plexus, which is responsible for regulating secretion and blood flow. The muscularis externa is the layer that lies beneath the submucosa and contains Auerbach’s plexus, which controls the motility of GI smooth muscle. Finally, the outermost layer of the GI tract is either the serosa or adventitia, depending on whether the organ is intraperitoneal or retroperitoneal. The serosa is responsible for secreting fluid to lubricate the organs, while the adventitia provides support and protection. Understanding the functions of each layer is important for understanding the overall function of the GI tract.
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This question is part of the following fields:
- Gastrointestinal System
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Question 155
Incorrect
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Sophie, a 5-year-old girl, visits her doctor with her mother, complaining of a lump in her groin that appears and disappears. The lump is easily reducible.
The doctor suspects an indirect inguinal hernia, although it is difficult to differentiate between femoral, direct inguinal, and indirect inguinal hernias in such a young patient.
Sophie's mother is curious about the cause of her daughter's hernia. What is the pathology of an indirect inguinal hernia?Your Answer: Protrusion through the failure of the tunica albuginea to regress
Correct Answer: Protrusion through the failure of the processus vaginalis to regress
Explanation:Indirect inguinal hernias are caused by the failure of the processus vaginalis to regress, resulting in a protrusion through the deep inguinal ring and into the inguinal canal. In males, it may progress into the scrotum, while in females, it may enter the labia. This type of hernia is located lateral to the epigastric vessels.
On the other hand, direct inguinal hernias are usually caused by weakening in the abdominal musculature, which occurs with age. The protrusion enters the inguinal canal through the posterior wall, which is medial to the epigastric vessels. It may exit through the superficial inguinal ring.
The tunica vaginalis is a layer that surrounds the testes and contains a small amount of serous fluid, reducing friction between the scrotum and the testes. Meanwhile, the tunica albuginea is a layer of connective tissue that covers the ovaries, testicles, and corpora cavernosa of the penis.
Understanding Inguinal Hernias
Inguinal hernias are the most common type of abdominal wall hernias, with 75% of cases falling under this category. They are more prevalent in men, with a 25% lifetime risk of developing one. The main symptom is a lump in the groin area, which disappears when pressure is applied or when the patient lies down. Discomfort and aching are also common, especially during physical activity. However, severe pain is rare, and strangulation is even rarer.
The traditional classification of inguinal hernias into indirect and direct types is no longer relevant in clinical management. Instead, the current consensus is to treat medically fit patients, even if they are asymptomatic. A hernia truss may be an option for those who are not fit for surgery, but it has limited use in other patients. Mesh repair is the preferred method, as it has the lowest recurrence rate. Unilateral hernias are usually repaired through an open approach, while bilateral and recurrent hernias are repaired laparoscopically.
After surgery, patients are advised to return to non-manual work after 2-3 weeks for open repair and 1-2 weeks for laparoscopic repair. Complications may include early bruising and wound infection, as well as late chronic pain and recurrence. It is important to seek medical attention if any of these symptoms occur.
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This question is part of the following fields:
- Gastrointestinal System
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Question 156
Correct
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A 55-year-old man is having surgery to remove a tumor in the descending colon. What embryological structure does this part of the digestive system originate from?
Your Answer: Hind gut
Explanation:The hind gut is responsible for the development of the left colon, which is why it has its own distinct blood supply through the IMA.
The colon begins with the caecum, which is the most dilated segment of the colon and is marked by the convergence of taenia coli. The ascending colon follows, which is retroperitoneal on its posterior aspect. The transverse colon comes after passing the hepatic flexure and becomes wholly intraperitoneal again. The splenic flexure marks the point where the transverse colon makes an oblique inferior turn to the left upper quadrant. The descending colon becomes wholly intraperitoneal at the level of L4 and becomes the sigmoid colon. The sigmoid colon is wholly intraperitoneal, but there are usually attachments laterally between the sigmoid and the lateral pelvic sidewall. At its distal end, the sigmoid becomes the upper rectum, which passes through the peritoneum and becomes extraperitoneal.
The arterial supply of the colon comes from the superior mesenteric artery and inferior mesenteric artery, which are linked by the marginal artery. The ascending colon is supplied by the ileocolic and right colic arteries, while the transverse colon is supplied by the middle colic artery. The descending and sigmoid colon are supplied by the inferior mesenteric artery. The venous drainage comes from regional veins that accompany arteries to the superior and inferior mesenteric vein. The lymphatic drainage initially follows nodal chains that accompany supplying arteries, then para-aortic nodes.
The colon has both intraperitoneal and extraperitoneal segments. The right and left colon are part intraperitoneal and part extraperitoneal, while the sigmoid and transverse colon are generally wholly intraperitoneal. The colon has various relations with other organs, such as the right ureter and gonadal vessels for the caecum/right colon, the gallbladder for the hepatic flexure, the spleen and tail of pancreas for the splenic flexure, the left ureter for the distal sigmoid/upper rectum, and the ureters, autonomic nerves, seminal vesicles, prostate, and urethra for the rectum.
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This question is part of the following fields:
- Gastrointestinal System
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Question 157
Incorrect
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A 65-year-old man is admitted to the surgical ward following an open surgical repair of a ruptured aortic aneurysm. During examination, he presents with a positive Grey Turner's sign, indicating retroperitoneal haemorrhage and resulting in blue discolouration of the flanks. Retroperitoneal haemorrhage can occur due to trauma to retroperitoneal structures. Can you identify which of the following structures is not retroperitoneal?
Your Answer: Ureters
Correct Answer: Tail of the pancreas
Explanation:The tail of the pancreas is the only intraperitoneal structure mentioned, while all the others are retroperitoneal. Retroperitoneal haemorrhage can be caused by various factors, including ruptured aneurysms and acute pancreatitis. A helpful mnemonic to remember retroperitoneal structures is SAD PUCKER.
Anatomy of the Pancreas
The pancreas is located behind the stomach and is a retroperitoneal organ. It can be accessed surgically by dividing the peritoneal reflection that connects the greater omentum to the transverse colon. The pancreatic head is situated in the curvature of the duodenum, while its tail is close to the hilum of the spleen. The pancreas has various relations with other organs, such as the inferior vena cava, common bile duct, renal veins, superior mesenteric vein and artery, crus of diaphragm, psoas muscle, adrenal gland, kidney, aorta, pylorus, gastroduodenal artery, and splenic hilum.
The arterial supply of the pancreas is through the pancreaticoduodenal artery for the head and the splenic artery for the rest of the organ. The venous drainage for the head is through the superior mesenteric vein, while the body and tail are drained by the splenic vein. The ampulla of Vater is an important landmark that marks the transition from foregut to midgut and is located halfway along the second part of the duodenum. Overall, understanding the anatomy of the pancreas is crucial for surgical procedures and diagnosing pancreatic diseases.
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This question is part of the following fields:
- Gastrointestinal System
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Question 158
Correct
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A 39-year-old man presents to his family physician with a persistent abdominal pain that has been bothering him for the past three months. He reports that the pain usually occurs after eating and has not been relieved with over-the-counter antacids and omeprazole. The patient denies any recent weight loss or difficulty swallowing. Upon examination, the abdomen is soft and non-tender. The physician orders a urea breath test, which comes back positive. What is the organism responsible for this patient's symptoms?
Your Answer: Gram-negative, oxidase positive, catalase positive comma-shaped rods
Explanation:The patient has peptic ulcer disease caused by Helicobacter pylori, which can also increase the risk of gastric adenocarcinoma. Triple therapy with two antibiotics and one proton-pump inhibitor is the standard treatment. Pseudomonas aeruginosa, Neisseria meningitidis, Vibrio cholerae, and Staphylococcus epidermidis are other bacteria with different types of infections they can cause.
Helicobacter pylori: A Bacteria Associated with Gastrointestinal Problems
Helicobacter pylori is a type of Gram-negative bacteria that is commonly associated with various gastrointestinal problems, particularly peptic ulcer disease. This bacterium has two primary mechanisms that allow it to survive in the acidic environment of the stomach. Firstly, it uses its flagella to move away from low pH areas and burrow into the mucous lining to reach the epithelial cells underneath. Secondly, it secretes urease, which converts urea to NH3, leading to an alkalinization of the acidic environment and increased bacterial survival.
The pathogenesis mechanism of Helicobacter pylori involves the release of bacterial cytotoxins, such as the CagA toxin, which can disrupt the gastric mucosa. This bacterium is associated with several gastrointestinal problems, including peptic ulcer disease, gastric cancer, B cell lymphoma of MALT tissue, and atrophic gastritis. However, its role in gastro-oesophageal reflux disease (GORD) is unclear, and there is currently no role for the eradication of Helicobacter pylori in GORD.
The management of Helicobacter pylori infection involves a 7-day course of treatment with a proton pump inhibitor, amoxicillin, and either clarithromycin or metronidazole. For patients who are allergic to penicillin, a proton pump inhibitor, metronidazole, and clarithromycin are used instead.
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This question is part of the following fields:
- Gastrointestinal System
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Question 159
Correct
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A 35-year-old woman came in with a 7-month history of upper abdominal pain and nausea. She reported no weight loss. An upper GI endoscopy showed mild gastritis, but her symptoms persisted even after a 3-month course of proton pump inhibitors. A CT scan was done and revealed a probable gastrinoma. Which type of cell does the hormone produced by this tumor target to stimulate acid secretion?
Your Answer: Parietal cell
Explanation:The secretion of H+ by gastric parietal cells is increased by gastrin.
Overview of Gastrointestinal Hormones
Gastrointestinal hormones play a crucial role in the digestion and absorption of food. These hormones are secreted by various cells in the stomach and small intestine in response to different stimuli such as the presence of food, pH changes, and neural signals.
One of the major hormones involved in food digestion is gastrin, which is secreted by G cells in the antrum of the stomach. Gastrin increases acid secretion by gastric parietal cells, stimulates the secretion of pepsinogen and intrinsic factor, and increases gastric motility. Another hormone, cholecystokinin (CCK), is secreted by I cells in the upper small intestine in response to partially digested proteins and triglycerides. CCK increases the secretion of enzyme-rich fluid from the pancreas, contraction of the gallbladder, and relaxation of the sphincter of Oddi. It also decreases gastric emptying and induces satiety.
Secretin is another hormone secreted by S cells in the upper small intestine in response to acidic chyme and fatty acids. Secretin increases the secretion of bicarbonate-rich fluid from the pancreas and hepatic duct cells, decreases gastric acid secretion, and has a trophic effect on pancreatic acinar cells. Vasoactive intestinal peptide (VIP) is a neural hormone that stimulates secretion by the pancreas and intestines and inhibits acid secretion.
Finally, somatostatin is secreted by D cells in the pancreas and stomach in response to fat, bile salts, and glucose in the intestinal lumen. Somatostatin decreases acid and pepsin secretion, decreases gastrin secretion, decreases pancreatic enzyme secretion, and decreases insulin and glucagon secretion. It also inhibits the trophic effects of gastrin and stimulates gastric mucous production.
In summary, gastrointestinal hormones play a crucial role in regulating the digestive process and maintaining homeostasis in the gastrointestinal tract.
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This question is part of the following fields:
- Gastrointestinal System
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Question 160
Correct
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A 32-year-old man comes to you complaining of persistent diarrhoea for the past 10 days. He describes his diarrhoea as watery and foul-smelling, but denies any blood. He feels exhausted and asks for a prescription for an antidiarrhoeal medication. He has no notable medical history.
The stool cultures come back negative, and you contemplate starting the patient on diphenoxylate. Can you explain the mechanism of action of this drug?Your Answer: Inhibits peristalsis by acting on μ-opioid in the GI tract
Explanation:Diphenoxylate slows down peristalsis in the GI tract by acting on μ-opioid receptors.
Increased gut motility can be achieved through the positive cholinergic effect of muscarinic receptor activation.
All other options are inaccurate.
Antidiarrhoeal Agents: Opioid Agonists
Antidiarrhoeal agents are medications used to treat diarrhoea. Opioid agonists are a type of antidiarrhoeal agent that work by slowing down the movement of the intestines, which reduces the frequency and urgency of bowel movements. Two common opioid agonists used for this purpose are loperamide and diphenoxylate.
Loperamide is available over-the-counter and is often used to treat acute diarrhoea. It works by binding to opioid receptors in the intestines, which reduces the contractions of the muscles in the intestinal wall. This slows down the movement of food and waste through the intestines, allowing more time for water to be absorbed and resulting in firmer stools.
Diphenoxylate is a prescription medication that is often used to treat chronic diarrhoea. It works in a similar way to loperamide, but is often combined with atropine to discourage abuse and overdose.
Overall, opioid agonists are effective at treating diarrhoea, but should be used with caution and under the guidance of a healthcare professional. They can cause side effects such as constipation, dizziness, and nausea, and may interact with other medications.
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This question is part of the following fields:
- Gastrointestinal System
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Question 161
Incorrect
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Samantha, a 52-year-old female, visits her doctor with a lump in her groin that becomes more prominent when she coughs. The lump is not painful, but the doctor notes that it is located inferior and lateral to the pubic tubercle during the examination. This leads to a diagnosis of a femoral hernia, where a portion of the bowel has entered the femoral canal and caused a bulge in the femoral triangle, an area in the upper thigh.
What are the contents of this anatomical region from lateral to medial?Your Answer: Lymphatics, empty space, femoral artery, femoral vein, femoral nerve
Correct Answer: Femoral nerve, femoral artery, femoral vein, empty space, lymphatics
Explanation:To remember the contents of the femoral triangle from lateral to medial, use the acronym NAVEL: femoral NERVE, femoral ARTERY, femoral VEIN, EMPTY space, and LYMPHATICS. The femoral triangle is located in the anterior thigh and is bordered by the inguinal ligament superiorly, the medial border of the sartorius muscle laterally, and the medial border of the adductor longus muscle medially. A femoral hernia occurs when bowel enters the femoral ring and canal, which are located beneath the inguinal ligament, causing a bulge in the femoral triangle. The femoral nerve is located more laterally than the femoral artery and vein, while the femoral artery is more lateral than the femoral vein.
Understanding the Anatomy of the Femoral Triangle
The femoral triangle is an important anatomical region located in the upper thigh. It is bounded by the inguinal ligament superiorly, the sartorius muscle laterally, and the adductor longus muscle medially. The floor of the femoral triangle is made up of the iliacus, psoas major, adductor longus, and pectineus muscles, while the roof is formed by the fascia lata and superficial fascia. The superficial inguinal lymph nodes and the long saphenous vein are also found in this region.
The femoral triangle contains several important structures, including the femoral vein, femoral artery, femoral nerve, deep and superficial inguinal lymph nodes, lateral cutaneous nerve, great saphenous vein, and femoral branch of the genitofemoral nerve. The femoral artery can be palpated at the mid inguinal point, making it an important landmark for medical professionals.
Understanding the anatomy of the femoral triangle is important for medical professionals, as it is a common site for procedures such as venipuncture, arterial puncture, and nerve blocks. It is also important for identifying and treating conditions that affect the structures within this region, such as femoral hernias and lymphadenopathy.
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This question is part of the following fields:
- Gastrointestinal System
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Question 162
Incorrect
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A 72-year-old man comes to the clinic with a left groin swelling and reports experiencing moderate pain and discomfort. The diagnosis is an inguinal hernia, and he is scheduled for elective surgery to repair the defect. During the procedure, which nerve running through the inguinal canal is at risk of being damaged?
Your Answer: Femoral nerve
Correct Answer: Ilioinguinal nerve
Explanation:The inguinal canal is a crucial anatomical structure that houses the spermatic cord in males and the ilioinguinal nerve in both genders. The ilioinguinal and iliohypogastric nerves stem from the L1 nerve root and run through the canal. The ilioinguinal nerve enters the canal via the abdominal muscles and exits through the external inguinal ring. It is primarily a sensory nerve that provides sensation to the upper medial thigh. If the nerve is damaged during hernia repair, patients may experience numbness in this area after surgery.
Other nerves that pass through the pelvis include the femoral nerve, which descends behind the inguinal canal, the obturator nerve, which travels through the obturator foramen, and the sciatic nerve, which exits the pelvis through the greater sciatic foramen and runs posteriorly.
The inguinal canal is located above the inguinal ligament and measures 4 cm in length. Its superficial ring is situated in front of the pubic tubercle, while the deep ring is found about 1.5-2 cm above the halfway point between the anterior superior iliac spine and the pubic tubercle. The canal is bounded by the external oblique aponeurosis, inguinal ligament, lacunar ligament, internal oblique, transversus abdominis, external ring, and conjoint tendon. In males, the canal contains the spermatic cord and ilioinguinal nerve, while in females, it houses the round ligament of the uterus and ilioinguinal nerve.
The boundaries of Hesselbach’s triangle, which are frequently tested, are located in the inguinal region. Additionally, the inguinal canal is closely related to the vessels of the lower limb, which should be taken into account when repairing hernial defects in this area.
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This question is part of the following fields:
- Gastrointestinal System
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Question 163
Correct
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A 72-year-old retired fisherman presents with a sudden episode of rectal bleeding. The bleeding was significant and included clots. He feels dizzy and has collapsed.
He reports experiencing heartburn regularly and takes lisinopril and bendroflumethiazide for hypertension, as well as aspirin and ibuprofen for hangovers. He drinks six large whisky measures and smokes 10 cigarettes daily.
During examination, he is apyrexial, his heart rate is 106 bpm, blood pressure is 108/74 mmHg, and his respiratory rate is 18. He appears pale and has epigastric tenderness.
What is the immediate action that should be taken?Your Answer: Give 1litre 0.9% NaCl over one hour
Explanation:Urgent Resuscitation Needed for Patient in Hypovolaemic Shock
A patient is experiencing hypovolaemic shock and requires immediate infusion of colloid or crystalloid. Waiting for eight hours is not an option, and dextrose is not recommended as it quickly moves out of the intravascular space. The patient will undergo endoscopy, but only after initial resuscitation. While regular omeprazole may help prevent recurrence, it is not urgent.
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This question is part of the following fields:
- Gastrointestinal System
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Question 164
Correct
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A 58-year-old man is having a superficial parotidectomy for a pleomorphic adenoma. What is the most superficially located structure encountered during the dissection of the parotid?
Your Answer: Facial nerve
Explanation:The facial nerve is situated at the surface of the parotid gland, followed by the retromandibular vein at a slightly deeper level, and the arterial layer at the deepest level.
The parotid gland is located in front of and below the ear, overlying the mandibular ramus. Its salivary duct crosses the masseter muscle, pierces the buccinator muscle, and drains adjacent to the second upper molar tooth. The gland is traversed by several structures, including the facial nerve, external carotid artery, retromandibular vein, and auriculotemporal nerve. The gland is related to the masseter muscle, medial pterygoid muscle, superficial temporal and maxillary artery, facial nerve, stylomandibular ligament, posterior belly of the digastric muscle, sternocleidomastoid muscle, stylohyoid muscle, internal carotid artery, mastoid process, and styloid process. The gland is supplied by branches of the external carotid artery and drained by the retromandibular vein. Its lymphatic drainage is to the deep cervical nodes. The gland is innervated by the parasympathetic-secretomotor, sympathetic-superior cervical ganglion, and sensory-greater auricular nerve. Parasympathetic stimulation produces a water-rich, serous saliva, while sympathetic stimulation leads to the production of a low volume, enzyme-rich saliva.
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This question is part of the following fields:
- Gastrointestinal System
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Question 165
Correct
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A 50-year-old man presents with a sudden exacerbation of arthralgia affecting his hands and wrists. He also complains of feeling excessively fatigued lately. The patient has a medical history of hypertension and type 2 diabetes mellitus. Upon examination, his BMI is found to be 35 kg/m2. Laboratory tests reveal:
- Na+ 140 mmol/l
- K+ 4.2 mmol/l
- Urea 3.8 mmol/l
- Creatinine 100 µmol/l
- Plasma glucose 11.8 mmol/l
- ALT 150 u/l
- Serum ferritin 2000 ng/ml
What is the most probable diagnosis?Your Answer: Haemochromatosis
Explanation:Hereditary haemochromatosis is a genetic disorder that affects how the body processes iron. It is inherited in an autosomal recessive pattern. The symptoms in the early stages can be vague and non-specific, such as feeling tired and experiencing joint pain. As the condition progresses, it can lead to chronic liver disease and a condition known as bronze diabetes, which is characterized by iron buildup in the pancreas causing diabetes, and a bronze or grey pigmentation of the skin. Based on the patient’s symptoms of joint pain, elevated ALT levels, and significantly high ferritin levels, it is highly likely that they have haemochromatosis.
Understanding Haemochromatosis: Symptoms and Complications
Haemochromatosis is a genetic disorder that affects iron absorption and metabolism, leading to iron accumulation in the body. It is caused by mutations in the HFE gene on both copies of chromosome 6. This disorder is prevalent in people of European descent, with 1 in 10 carrying a mutation in the genes affecting iron metabolism. Early symptoms of haemochromatosis are often non-specific, such as lethargy and arthralgia, and may go unnoticed. However, as the disease progresses, patients may experience fatigue, erectile dysfunction, and skin pigmentation.
Other complications of haemochromatosis include diabetes mellitus, liver disease, cardiac failure, hypogonadism, and arthritis. While some symptoms are reversible with treatment, such as cardiomyopathy, skin pigmentation, diabetes mellitus, hypogonadotrophic hypogonadism, and arthropathy, liver cirrhosis is irreversible.
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This question is part of the following fields:
- Gastrointestinal System
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Question 166
Correct
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A 36 year old man presents with sudden onset of abdominal pain. He reports experiencing colicky pain for the past 12 hours along with nausea. He also mentions that he has not had a bowel movement and cannot recall passing gas.
The patient has a history of undergoing an emergency laparotomy due to a stabbing incident 8 years ago.
Upon examination, the abdomen is tender throughout but feels soft to the touch and produces a tympanic sound when percussed. High-pitched bowel sounds are audible upon auscultation.
An abdominal X-ray reveals multiple dilated small bowel loops.
What is the most probable cause of this patient's bowel obstruction?Your Answer: Small bowel adhesions
Explanation:Intussusception is a common cause of bowel obstruction in children under the age of two. Although most cases are asymptomatic, symptoms may occur and include rectal bleeding, volvulus, intussusception, bowel obstruction, or a presentation similar to acute appendicitis.
While a malignancy in the small bowel is a potential cause of obstruction in this age group, it is extremely rare and therefore less likely in this particular case.
Imaging for Bowel Obstruction
Bowel obstruction is a condition that requires immediate medical attention. One of the key indications for performing an abdominal film is to look for small and large bowel obstruction. The maximum normal diameter for the small bowel is 35 mm, while for the large bowel, it is 55 mm. The valvulae conniventes extend all the way across the small bowel, while the haustra extend about a third of the way across the large bowel.
A small bowel obstruction can be identified through distension of small bowel loops proximally, such as the duodenum and jejunum, with an abrupt transition to an intestinal segment of normal caliber. There may also be a small amount of free fluid intracavity. On the other hand, a large bowel obstruction can be identified through the presence of haustra extending about a third of the way across and a maximum normal diameter of 55 mm.
Imaging for bowel obstruction is crucial in diagnosing and treating the condition promptly. It is important to note that early detection and intervention can prevent complications and improve patient outcomes.
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This question is part of the following fields:
- Gastrointestinal System
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Question 167
Correct
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Which one of the following statements relating to the greater omentum is false?
Your Answer: It has no relationship to the lesser sac.
Explanation:This area is linked to the transverse colon and the lesser sac, and is often accessed during a colonic resection. It is also frequently affected by metastasis in various types of visceral cancers.
The Omentum: A Protective Structure in the Abdomen
The omentum is a structure in the abdomen that invests the stomach and is divided into two parts: the greater and lesser omentum. The greater omentum is attached to the lower lateral border of the stomach and contains the gastro-epiploic arteries. It varies in size and is less developed in children. However, it plays an important role in protecting against visceral perforation, such as in cases of appendicitis.
The lesser omentum is located between the omentum and transverse colon, providing a potential entry point into the lesser sac. Malignant processes can affect the omentum, with ovarian cancer being the most notable. Overall, the omentum is a crucial structure in the abdomen that serves as a protective barrier against potential injuries and diseases.
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This question is part of the following fields:
- Gastrointestinal System
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Question 168
Correct
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An 80-year-old man visits his GP complaining of abdominal pain, early satiety, lethargy, and weight loss. After conducting several tests, he is diagnosed with gastric adenocarcinoma following an endoscopic biopsy. What is the most probable histological characteristic that will be observed in the biopsy?
Your Answer: Signet ring cells
Explanation:Gastric cancer is a relatively uncommon type of cancer, accounting for only 2% of all cancer diagnoses in developed countries. It is more prevalent in older individuals, with half of patients being over the age of 75, and is more common in males than females. Several risk factors have been identified, including Helicobacter pylori infection, atrophic gastritis, certain dietary habits, smoking, and blood group. Symptoms of gastric cancer can include abdominal pain, weight loss, nausea, vomiting, and dysphagia. In some cases, lymphatic spread may result in the appearance of nodules in the left supraclavicular lymph node or periumbilical area. Diagnosis is typically made through oesophago-gastro-duodenoscopy with biopsy, and staging is done using CT. Treatment options depend on the extent and location of the cancer and may include endoscopic mucosal resection, partial or total gastrectomy, and chemotherapy.
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This question is part of the following fields:
- Gastrointestinal System
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Question 169
Correct
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An 80-year-old man who frequently drinks alcohol presents to his doctor with symptoms of productive cough, fever, and chills. Upon examination, a chest x-ray reveals a distinct cavity in the right lower lobe with an air-fluid level. The patient's sputum is sent for culture and sensitivity, and he is prescribed clindamycin.
After ten days, the patient reports experiencing watery diarrhea 3-4 times a day and abdominal pain. He has not experienced any fever or weight loss, and his vital signs are normal. What is the initial medication recommended for his condition?Your Answer: Vancomycin
Explanation:The preferred antibiotic for treating C. difficile infection is oral vancomycin. However, in the case of a patient with clinical features and radiological findings indicative of a lung abscess, who also has a history of alcohol consumption that increases the risk of aspiration and lung abscesses, clindamycin was used as a treatment. Unfortunately, this led to the development of a C. difficile infection, which can be confusing when considering the antibiotics involved in causing and treating the infection.
Clostridium difficile is a type of bacteria that is commonly found in hospitals. It produces a toxin that can damage the intestines and cause a condition called pseudomembranous colitis. This bacteria usually develops when the normal gut flora is disrupted by broad-spectrum antibiotics, with second and third generation cephalosporins being the leading cause. Other risk factors include the use of proton pump inhibitors. Symptoms of C. difficile infection include diarrhea, abdominal pain, and a raised white blood cell count. The severity of the infection can be determined using the Public Health England severity scale.
To diagnose C. difficile infection, a stool sample is tested for the presence of the C. difficile toxin. Treatment involves reviewing current antibiotic therapy and stopping antibiotics if possible. For a first episode of infection, oral vancomycin is the first-line therapy for 10 days, followed by oral fidaxomicin as second-line therapy and oral vancomycin with or without IV metronidazole as third-line therapy. Recurrent infections may require different treatment options, such as oral fidaxomicin within 12 weeks of symptom resolution or oral vancomycin or fidaxomicin after 12 weeks of symptom resolution. In life-threatening cases, oral vancomycin and IV metronidazole may be used, and surgery may be considered with specialist advice. Other therapies, such as bezlotoxumab and fecal microbiota transplant, may also be considered for preventing recurrences in certain cases.
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This question is part of the following fields:
- Gastrointestinal System
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Question 170
Correct
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During a ward round on the gastroenterology ward, you assess a 75-year-old man with a history of hepatocellular carcinoma. He spent most of his life in Pakistan, where he consumed a diet high in grains and chicken. He has never contracted a hepatitis virus. Despite being a non-smoker, he has resided in a household where other inhabitants smoke indoors for the majority of his adult life.
What is the potential risk factor for hepatocellular carcinoma that this patient may have been exposed to?Your Answer: Aflatoxin
Explanation:Hepatocellular carcinoma is commonly caused by chronic hepatitis B infection worldwide and chronic hepatitis C infection in Europe. However, there are other significant risk factors to consider, such as aflatoxins. These toxic carcinogens are produced by certain types of mold and can be found in improperly stored grains and seeds. While Caroli’s disease and primary sclerosing cholangitis are risk factors for cholangiocarcinoma, they are less significant for hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) is a type of cancer that ranks third in terms of prevalence worldwide. The most common cause of HCC globally is chronic hepatitis B, while chronic hepatitis C is the leading cause in Europe. The primary risk factor for developing HCC is liver cirrhosis, which can result from various factors such as hepatitis B & C, alcohol, haemochromatosis, and primary biliary cirrhosis. Other risk factors include alpha-1 antitrypsin deficiency, hereditary tyrosinosis, glycogen storage disease, aflatoxin, certain drugs, porphyria cutanea tarda, male sex, diabetes mellitus, and metabolic syndrome.
HCC often presents late and may exhibit features of liver cirrhosis or failure such as jaundice, ascites, RUQ pain, hepatomegaly, pruritus, and splenomegaly. In some cases, it may manifest as decompensation in patients with chronic liver disease. Elevated levels of alpha-fetoprotein (AFP) are also common. High-risk groups such as patients with liver cirrhosis secondary to hepatitis B & C or haemochromatosis, and men with liver cirrhosis secondary to alcohol should undergo screening with ultrasound (+/- AFP).
Management options for early-stage HCC include surgical resection, liver transplantation, radiofrequency ablation, transarterial chemoembolisation, and sorafenib, a multikinase inhibitor. Proper management and early detection are crucial in improving the prognosis of HCC.
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This question is part of the following fields:
- Gastrointestinal System
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Question 171
Correct
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A 20-year-old woman currently completing her exams presents to her GP with fatigue and generalised weakness. She has also noted that her skin and the whites of her eyes appear yellow. The GP suspects the patient may have Gilbert’s syndrome and orders liver function tests to determine the patient’s baseline liver function. The GP advises the patient that no treatment is necessary for this condition.
Reference range
Bilirubin 3 - 17 µmol/L
ALP 30 - 100 u/L
ALT 3 - 40 u/L
γGT 8 - 60 u/L
Albumin 35 - 50 g/L
LDH 100 - 190 U/L
What set of results would be expected from this patient?Your Answer: Bilirubin 40 umol/l, ALT 15 U/L, LDH 160 U/L, GGT 25 U/L
Explanation:Jaundice becomes visible when bilirubin levels exceed 35 umol/l. Therefore, the correct option is the one with a bilirubin level of 40 umol/l, as this is typically the range where jaundice becomes visible. Furthermore, all other liver function values in this option are within the normal range. The other options are incorrect because they have bilirubin levels that are too low to cause visible jaundice, and the liver function results are usually normal in cases of Gilbert’s syndrome.
Understanding Bilirubin and Its Role in Jaundice
Bilirubin is a chemical by-product that is produced when red blood cells break down heme, a component found in these cells. This chemical is also found in other hepatic heme-containing proteins like myoglobin. The heme is processed within macrophages and oxidized to form biliverdin and iron. Biliverdin is then reduced to form unconjugated bilirubin, which is released into the bloodstream.
Unconjugated bilirubin is bound to albumin in the blood and then taken up by hepatocytes, where it is conjugated to make it water-soluble. From there, it is excreted into bile and enters the intestines to be broken down by intestinal bacteria. Bacterial proteases produce urobilinogen from bilirubin within the intestinal lumen, which is further processed by intestinal bacteria to form urobilin and stercobilin and excreted via the faeces. A small amount of bilirubin re-enters the portal circulation to be finally excreted via the kidneys in urine.
Jaundice occurs when bilirubin levels exceed 35 umol/l. Raised levels of unconjugated bilirubin may occur due to haemolysis, while hepatocyte defects, such as a compromised hepatocyte uptake of unconjugated bilirubin and/or defective conjugation, may occur in liver disease or deficiency of glucuronyl transferase. Raised levels of conjugated bilirubin can result from defective excretion of bilirubin, for example, Dubin-Johnson Syndrome, or cholestasis.
Cholestasis can result from a wide range of pathologies, which can be largely divided into physical causes, for example, gallstones, pancreatic and cholangiocarcinoma, or functional causes, for example, drug-induced, pregnancy-related and postoperative cholestasis. Understanding bilirubin and its role in jaundice is important in diagnosing and treating various liver and blood disorders.
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This question is part of the following fields:
- Gastrointestinal System
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Question 172
Correct
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A 32-year-old male patient is diagnosed with a peptic ulcer. What is the source of gastric acid secretion?
Your Answer: Parietal cells
Explanation:Gastric acid is released by parietal cells, while Brunner’s glands are located in the duodenum.
Understanding Gastric Secretions for Surgical Procedures
A basic understanding of gastric secretions is crucial for surgeons, especially when dealing with patients who have undergone acid-lowering procedures or are prescribed anti-secretory drugs. Gastric acid, produced by the parietal cells in the stomach, has a pH of around 2 and is maintained by the H+/K+ ATPase pump. Sodium and chloride ions are actively secreted from the parietal cell into the canaliculus, creating a negative potential across the membrane. Carbonic anhydrase forms carbonic acid, which dissociates, and the hydrogen ions formed by dissociation leave the cell via the H+/K+ antiporter pump. This leaves hydrogen and chloride ions in the canaliculus, which mix and are secreted into the lumen of the oxyntic gland.
There are three phases of gastric secretion: the cephalic phase, gastric phase, and intestinal phase. The cephalic phase is stimulated by the smell or taste of food and causes 30% of acid production. The gastric phase, which is caused by stomach distension, low H+, or peptides, causes 60% of acid production. The intestinal phase, which is caused by high acidity, distension, or hypertonic solutions in the duodenum, inhibits gastric acid secretion via enterogastrones and neural reflexes.
The regulation of gastric acid production involves various factors that increase or decrease production. Factors that increase production include vagal nerve stimulation, gastrin release, and histamine release. Factors that decrease production include somatostatin, cholecystokinin, and secretin. Understanding these factors and their associated pharmacology is essential for surgeons.
In summary, a working knowledge of gastric secretions is crucial for surgical procedures, especially when dealing with patients who have undergone acid-lowering procedures or are prescribed anti-secretory drugs. Understanding the phases of gastric secretion and the regulation of gastric acid production is essential for successful surgical outcomes.
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This question is part of the following fields:
- Gastrointestinal System
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Question 173
Correct
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A 42-year-old female presents to the emergency department with severe generalised abdominal pain and haematemesis. The patient reports ongoing epigastric pain over the past few months which was worse after eating meals. She had a similar but milder episode about 4 years ago, which was treated with omeprazole. Past medical history includes osteoarthritis for which she takes ibuprofen.
Clinical observations reveal a heart rate of 120 beats per minute, blood pressure of 90/78 mmHg, respiratory rate of 25/min, oxygen saturations of 98% on air and a temperature of 37.5ºC. On examination, the patient has severe epigastric tenderness on palpation.
What is the first-line treatment for the likely diagnosis?Your Answer: Endoscopic intervention
Explanation:The most likely diagnosis for the patient is a perforated peptic ulcer, which may have been caused by their use of ibuprofen. The recommended first-line treatment according to NICE guidelines is endoscopic intervention, which can confirm the diagnosis and stop the bleeding. This involves injecting adrenaline into the bleeding site and using cautery and/or clip application. Helicobacter pylori eradication therapy is not appropriate in this case, as the patient’s symptoms suggest a perforated peptic ulcer rather than peptic ulcer disease caused by H. pylori. IV proton-pump inhibitor infusion may be considered later, but the patient requires immediate management with endoscopic intervention.
Managing Acute Bleeding in Peptic Ulcer Disease
Peptic ulcer disease is a condition that can lead to acute bleeding, which is the most common complication of the disease. In fact, bleeding accounts for about three-quarters of all problems associated with peptic ulcer disease. The gastroduodenal artery is often the source of significant gastrointestinal bleeding in patients with this condition. The most common symptom of acute bleeding in peptic ulcer disease is haematemesis, but patients may also experience melaena, hypotension, and tachycardia.
When managing acute bleeding in peptic ulcer disease, an ABC approach should be taken, as with any upper gastrointestinal haemorrhage. Intravenous proton pump inhibitors are the first-line treatment, and endoscopic intervention is typically the preferred approach. However, if endoscopic intervention fails (which occurs in approximately 10% of patients), urgent interventional angiography with transarterial embolization or surgery may be necessary. By following these management strategies, healthcare providers can effectively address acute bleeding in patients with peptic ulcer disease.
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This question is part of the following fields:
- Gastrointestinal System
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Question 174
Correct
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A 75-year-old man presents to the emergency department complaining of diffuse abdominal pain that has been ongoing for several hours. He reports passing bloody stool during a recent bowel movement. Upon examination, you observe an irregular pulse and a tender abdomen. After conducting tests, you diagnose the patient with ischaemic colitis affecting the transverse colon.
What other organ receives blood supply from the same branch of the aorta at the vertebral level L1?Your Answer: 4th part of the duodenum
Explanation:The splenic flexure of the colon marks the boundary between the midgut and the hindgut.
When a blood clot travels to the abdominal arteries and blocks the blood supply to a section of the gut, it can lead to ischaemic colitis. This condition is more prevalent in older individuals, and those with atrial fibrillation (as indicated by the patient’s irregular pulse) are at a higher risk. The area most commonly affected is the watershed region of the colon, where blood supply transitions from one artery to another. This region is the junction between the midgut and the hindgut.
The superior mesenteric artery supplies the midgut, which includes the proximal transverse colon.
The foregut-derived organs, such as the 1st part of the duodenum, spleen, and liver, are supplied by the coeliac trunk.
The hindgut includes the descending colon, which is supplied by the inferior mesenteric artery.
The Three Embryological Layers and their Corresponding Gastrointestinal Structures and Blood Supply
The gastrointestinal system is a complex network of organs responsible for the digestion and absorption of nutrients. During embryonic development, the gastrointestinal system is formed from three distinct layers: the foregut, midgut, and hindgut. Each layer gives rise to specific structures and is supplied by a corresponding blood vessel.
The foregut extends from the mouth to the proximal half of the duodenum and is supplied by the coeliac trunk. The midgut encompasses the distal half of the duodenum to the splenic flexure of the colon and is supplied by the superior mesenteric artery. Lastly, the hindgut includes the descending colon to the rectum and is supplied by the inferior mesenteric artery.
Understanding the embryological origin and blood supply of the gastrointestinal system is crucial in diagnosing and treating gastrointestinal disorders. By identifying the specific structures and blood vessels involved, healthcare professionals can better target their interventions and improve patient outcomes.
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This question is part of the following fields:
- Gastrointestinal System
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Question 175
Correct
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A 35-year-old male presents to his general practitioner complaining of severe left flank pain that comes and goes. The doctor suspects a kidney stone and refers him for a CT scan. However, before the scan, the stone ruptures through the organ wall and urine starts to leak. Which of the following organs is most likely to come into contact with the leaked urine?
Your Answer: Inferior vena cava
Explanation:The ureters are situated behind the peritoneum and any damage to them can result in the accumulation of fluid in the retroperitoneal space.
Kidney stones are most likely to get stuck in the ureter, specifically at the uretopelvic junction, pelvic brim, or vesicoureteric junction. Since the entire ureter is located behind the peritoneum, any rupture could cause urine to leak into the retroperitoneal space. This space is connected to other organs behind the peritoneum, such as the inferior vena cava.
All the other organs mentioned are located within the peritoneum.
The retroperitoneal structures are those that are located behind the peritoneum, which is the membrane that lines the abdominal cavity. These structures include the duodenum (2nd, 3rd, and 4th parts), ascending and descending colon, kidneys, ureters, aorta, and inferior vena cava. They are situated in the back of the abdominal cavity, close to the spine. In contrast, intraperitoneal structures are those that are located within the peritoneal cavity, such as the stomach, duodenum (1st part), jejunum, ileum, transverse colon, and sigmoid colon. It is important to note that the retroperitoneal structures are not well demonstrated in the diagram as the posterior aspect has been removed, but they are still significant in terms of their location and function.
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This question is part of the following fields:
- Gastrointestinal System
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Question 176
Correct
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A 45-year-old female presents to the emergency department with severe back pain and no medical history except for a penicillin allergy. Following an MRI, she is diagnosed with osteomyelitis and prescribed a 6-week course of two antibiotics. However, a few days into treatment, she reports abdominal pain and diarrhea. Stool samples reveal the presence of Clostridium difficile toxins, leading to a diagnosis of pseudomembranous colitis. Which antibiotic is the most likely culprit for causing the C. difficile colitis?
Your Answer: Clindamycin
Explanation:The use of clindamycin as a treatment is linked to a significant risk of developing C. difficile infection. This antibiotic is commonly associated with Clostridium difficile colitis. Doxycycline has the potential to cause sensitivity to sunlight and birth defects, while trimethoprim can lead to high levels of potassium in the blood and is also harmful to developing fetuses. Vancomycin, on the other hand, can cause red man syndrome and is among the medications used to treat Clostridium difficile colitis.
Clostridium difficile is a type of bacteria that is commonly found in hospitals. It produces a toxin that can damage the intestines and cause a condition called pseudomembranous colitis. This bacteria usually develops when the normal gut flora is disrupted by broad-spectrum antibiotics, with second and third generation cephalosporins being the leading cause. Other risk factors include the use of proton pump inhibitors. Symptoms of C. difficile infection include diarrhea, abdominal pain, and a raised white blood cell count. The severity of the infection can be determined using the Public Health England severity scale.
To diagnose C. difficile infection, a stool sample is tested for the presence of the C. difficile toxin. Treatment involves reviewing current antibiotic therapy and stopping antibiotics if possible. For a first episode of infection, oral vancomycin is the first-line therapy for 10 days, followed by oral fidaxomicin as second-line therapy and oral vancomycin with or without IV metronidazole as third-line therapy. Recurrent infections may require different treatment options, such as oral fidaxomicin within 12 weeks of symptom resolution or oral vancomycin or fidaxomicin after 12 weeks of symptom resolution. In life-threatening cases, oral vancomycin and IV metronidazole may be used, and surgery may be considered with specialist advice. Other therapies, such as bezlotoxumab and fecal microbiota transplant, may also be considered for preventing recurrences in certain cases.
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This question is part of the following fields:
- Gastrointestinal System
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Question 177
Correct
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A 59-year-old male arrives at the emergency department complaining of severe abdominal pain, vomiting, and swelling in the central abdomen.
During his last visit to his family doctor two weeks ago, he experienced colicky abdominal pain and was diagnosed with gallstones after further testing. He was scheduled for an elective cholecystectomy in 8 weeks.
The patient is administered pain relief and scheduled for an urgent abdominal X-ray (AXR).
What is the most probable finding on the AXR that indicates a cholecystoenteric fistula?Your Answer: Pneumobilia
Explanation:The presence of air in the gallbladder and biliary tree on an abdominal X-ray is most likely caused by a cholecystoenteric fistula. This is a serious complication of gallstones, particularly those larger than 2 cm, and can result in symptoms of small bowel obstruction such as severe abdominal pain, vomiting, and abdominal distension. While pneumoperitoneum may also be present in cases of cholecystoenteric fistula, it is not a specific finding and can be caused by other factors that weaken or tear hollow viscus organs. On the other hand, the presence of an appendicolith, a small calcified stone in the appendix, is highly indicative of appendicitis in patients with right iliac fossa pain and other associated symptoms, but is not seen in cases of cholecystoenteric fistula on an abdominal X-ray.
Gallstones are a common condition, with up to 24% of women and 12% of men affected. Local infection and cholecystitis may develop in up to 30% of cases, and 12% of patients undergoing surgery will have stones in the common bile duct. The majority of gallstones are of mixed composition, with pure cholesterol stones accounting for 20% of cases. Symptoms typically include colicky right upper quadrant pain that worsens after fatty meals. Diagnosis is usually made through abdominal ultrasound and liver function tests, with magnetic resonance cholangiography or intraoperative imaging used to confirm suspected bile duct stones. Treatment options include expectant management for asymptomatic gallstones, laparoscopic cholecystectomy for symptomatic gallstones, and surgical management for stones in the common bile duct. ERCP may be used to remove bile duct stones, but carries risks such as bleeding, duodenal perforation, cholangitis, and pancreatitis.
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This question is part of the following fields:
- Gastrointestinal System
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Question 178
Correct
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A 65-year-old woman visits her GP after discovering a lump in her groin that has been present for the past 2 weeks. The patient reports that she can push the lump back in, but it returns when she coughs. During the examination, the GP identifies the lump located superior and medial to the pubic tubercle. The GP successfully reduces the lump by applying pressure 2 cm above the midpoint of the inguinal ligament and asking the patient to cough. Based on the findings, the GP suspects an indirect inguinal hernia. What structures will the hernia pass through anatomically?
Your Answer: Deep inguinal ring and superficial inguinal ring
Explanation:The correct answer is that an indirect inguinal hernia enters the inguinal canal through the deep inguinal ring and exits at the superficial inguinal ring. This type of hernia is diagnosed by preventing re-herniation through pressure on the deep ring.
In contrast, a direct inguinal hernia enters the inguinal canal by passing through the posterior wall of the canal. This type of hernia would reappear upon increased intra-abdominal pressure, such as coughing.
The inguinal canal is located above the inguinal ligament and measures 4 cm in length. Its superficial ring is situated in front of the pubic tubercle, while the deep ring is found about 1.5-2 cm above the halfway point between the anterior superior iliac spine and the pubic tubercle. The canal is bounded by the external oblique aponeurosis, inguinal ligament, lacunar ligament, internal oblique, transversus abdominis, external ring, and conjoint tendon. In males, the canal contains the spermatic cord and ilioinguinal nerve, while in females, it houses the round ligament of the uterus and ilioinguinal nerve.
The boundaries of Hesselbach’s triangle, which are frequently tested, are located in the inguinal region. Additionally, the inguinal canal is closely related to the vessels of the lower limb, which should be taken into account when repairing hernial defects in this area.
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This question is part of the following fields:
- Gastrointestinal System
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Question 179
Incorrect
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A 36-year-old male with a history of prolonged NSAID use and gastroesophageal reflux disease presents to the acute surgical unit complaining of abdominal pain and hematemesis. During an endoscopy to investigate a suspected upper gastrointestinal bleed, a gastric ulcer is discovered on the posterior aspect of the stomach body that has eroded through an artery. Which specific artery is most likely to have been affected?
Your Answer: Gastroduodenal artery
Correct Answer: Splenic artery
Explanation:Acute upper gastrointestinal bleeding is a common and significant medical issue that can be caused by various conditions, with oesophageal varices and peptic ulcer disease being the most common. The main symptoms include haematemesis (vomiting of blood), melena (passage of altered blood per rectum), and a raised urea level due to the protein meal of the blood. The diagnosis can be determined by identifying the specific features associated with a particular condition, such as stigmata of chronic liver disease for oesophageal varices or abdominal pain for peptic ulcer disease.
The differential diagnosis for acute upper gastrointestinal bleeding includes oesophageal, gastric, and duodenal causes. Oesophageal varices may present with a large volume of fresh blood, while gastric ulcers may cause low volume bleeds that present as iron deficiency anaemia. Duodenal ulcers are usually posteriorly sited and may erode the gastroduodenal artery. Aorto-enteric fistula is a rare but important cause of major haemorrhage associated with high mortality in patients with previous abdominal aortic aneurysm surgery.
The management of acute upper gastrointestinal bleeding involves risk assessment using the Glasgow-Blatchford score, which helps clinicians decide whether patients can be managed as outpatients or not. Resuscitation involves ABC, wide-bore intravenous access, and platelet transfusion if actively bleeding platelet count is less than 50 x 10*9/litre. Endoscopy should be offered immediately after resuscitation in patients with a severe bleed, and all patients should have endoscopy within 24 hours. Treatment options include repeat endoscopy, interventional radiology, and surgery for non-variceal bleeding, while terlipressin and prophylactic antibiotics should be given to patients with variceal bleeding. Band ligation should be used for oesophageal varices, and injections of N-butyl-2-cyanoacrylate for patients with gastric varices. Transjugular intrahepatic portosystemic shunts (TIPS) should be offered if bleeding from varices is not controlled with the above measures.
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This question is part of the following fields:
- Gastrointestinal System
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Question 180
Correct
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A 63-year-old female patient arrives at the emergency department complaining of severe, sudden-onset abdominal pain that has been ongoing for an hour. She describes the pain as intense and cramping, with a severity rating of 9/10.
The patient has a medical history of hypertension, type 2 diabetes, and atrial fibrillation.
After undergoing a contrast CT scan, a thrombus is discovered in the inferior mesenteric artery, and the patient is immediately scheduled for an urgent laparotomy.
What structures are likely to be affected based on this diagnosis?Your Answer: Distal third of colon and the rectum superior to pectinate line
Explanation:The inferior mesenteric artery is responsible for supplying blood to the hindgut, which includes the distal third of the colon and the rectum superior to the pectinate line. In this case, the patient’s sudden onset of severe abdominal pain and history of atrial fibrillation suggest acute mesenteric ischemia, with the affected artery being the inferior mesenteric artery. Therefore, if a thrombus were to block this artery, the distal third of the colon and superior rectum would experience ischaemic changes. It is important to note that the ascending colon, caecum, ileum, appendix, greater omentum, and stomach are supplied by different arteries and would not be affected by a thrombus in the inferior mesenteric artery.
The Inferior Mesenteric Artery: Supplying the Hindgut
The inferior mesenteric artery (IMA) is responsible for supplying the embryonic hindgut with blood. It originates just above the aortic bifurcation, at the level of L3, and passes across the front of the aorta before settling on its left side. At the point where the left common iliac artery is located, the IMA becomes the superior rectal artery.
The hindgut, which includes the distal third of the colon and the rectum above the pectinate line, is supplied by the IMA. The left colic artery is one of the branches that emerges from the IMA near its origin. Up to three sigmoid arteries may also exit the IMA to supply the sigmoid colon further down the line.
Overall, the IMA plays a crucial role in ensuring that the hindgut receives the blood supply it needs to function properly. Its branches help to ensure that the colon and rectum are well-nourished and able to carry out their important digestive functions.
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This question is part of the following fields:
- Gastrointestinal System
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Question 181
Incorrect
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A 50-year-old man has been experiencing reflux oesophagitis for a prolonged period. In a recent endoscopy, a biopsy is obtained from the distal oesophagus. The histopathology report reveals the presence of cells with coarse chromatin and abnormal mitoses, which are limited to the superficial epithelial layer. What is the cause of this process?
Your Answer: Metaplasia
Correct Answer: Dysplasia
Explanation:Dysplasia is a condition that is considered pre-cancerous. It typically arises due to prolonged exposure to certain triggers. However, it may be possible to reverse these changes by eliminating the triggers. It is important to note that dysplasia involves the replacement of differentiated cells with abnormal cells, but it is not the same as metaplasia. Unlike cancer, dysplasia does not involve the invasion of surrounding tissues.
Understanding Dysplasia: A Premalignant Condition
Dysplasia is a premalignant condition characterized by disordered growth and differentiation of cells. It is a condition where there is an alteration in the size, shape, and organization of cells, resulting in increased abnormal cell growth, including an increased number of mitoses/abnormal mitoses and cellular differentiation. Dysplasia is often caused by factors such as smoking, Helicobacter pylori, and Human papillomavirus.
One of the main differences between dysplasia and metaplasia is that dysplasia is considered to be part of carcinogenesis (pre-cancerous) and is associated with a delay in the maturation of cells rather than differentiated cells replacing one another. Another key difference is that the underlying connective tissue is not invaded in dysplasia, which differentiates it from invasive malignancy.
It is important to note that severe dysplasia with foci of invasion is well recognized. Therefore, early detection and treatment of dysplasia are crucial in preventing the development of invasive malignancy. Understanding dysplasia and its causes can help individuals take preventive measures and seek medical attention if necessary.
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This question is part of the following fields:
- Gastrointestinal System
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Question 182
Correct
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A patient with a history of diverticular disease presents to the surgical assessment unit with abdominal pain and a fever. Her white blood cell count is elevated, but she is otherwise stable. The diagnosis is diverticulitis. What is the best course of action for managing this condition?
Your Answer: Antibiotics, a liquid diet and analgesia
Explanation:The initial management approach for mild diverticulitis typically involves a combination of oral antibiotics, a liquid diet, and analgesia.
Understanding Diverticulitis
Diverticulitis is a condition where an out-pouching of the intestinal mucosa becomes infected. This out-pouching is called a diverticulum and the presence of these pouches is known as diverticulosis. Diverticula are common and are thought to be caused by increased pressure in the colon. They usually occur in the sigmoid colon and are more prevalent in Westerners over the age of 60. While only a quarter of people with diverticulosis experience symptoms, 75% of those who do will have an episode of diverticulitis.
Risk factors for diverticulitis include age, lack of dietary fiber, obesity (especially in younger patients), and a sedentary lifestyle. Patients with diverticular disease may experience intermittent abdominal pain, bloating, and changes in bowel habits. Those with acute diverticulitis may experience severe abdominal pain, nausea and vomiting, changes in bowel habits, and urinary symptoms. Complications may include colovesical or colovaginal fistulas.
Signs of diverticulitis include low-grade fever, tachycardia, tender lower left quadrant of the abdomen, and possibly a palpable mass. Imaging tests such as an erect chest X-ray, abdominal X-ray, and CT scan may be used to diagnose diverticulitis. Treatment may involve oral antibiotics, a liquid diet, and analgesia for mild cases. More severe cases may require hospitalization for intravenous antibiotics. Colonoscopy should be avoided initially due to the risk of perforation.
In summary, diverticulitis is a common condition that can cause significant discomfort and complications. Understanding the risk factors, symptoms, and signs of diverticulitis can help with early diagnosis and treatment.
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This question is part of the following fields:
- Gastrointestinal System
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Question 183
Incorrect
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An 80-year-old man has been experiencing dysphagia and regurgitation of undigested food for the past 2 months. He also complains of halitosis and a chronic cough. During examination, a small neck swelling is observed which gurgles on palpation. Barium studies reveal a diverticulum or pouch forming at the junction of the pharynx and the esophagus. Can you identify between which muscles this diverticulum commonly occurs?
Your Answer: Salpingopharyngeus and palatopharyngeus muscles
Correct Answer: Thyropharyngeus and cricopharyngeus muscles
Explanation:A posteromedial diverticulum located between the thyropharyngeus and cricopharyngeus muscles is the cause of a pharyngeal pouch, also known as Zenker’s diverticulum. This triangular gap, called Killian’s dehiscence, is where the pouch develops. When food or other materials accumulate in this area, it can lead to symptoms such as neck swelling, regurgitation, and bad breath.
A pharyngeal pouch, also known as Zenker’s diverticulum, is a condition where there is a protrusion in the back of the throat through a weak area in the pharynx wall. This weak area is called Killian’s dehiscence and is located between two muscles. It is more common in older men and can cause symptoms such as difficulty swallowing, regurgitation, aspiration, neck swelling, and bad breath. To diagnose this condition, a barium swallow test combined with dynamic video fluoroscopy is usually performed. Treatment typically involves surgery.
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This question is part of the following fields:
- Gastrointestinal System
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Question 184
Incorrect
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Sophie presents acutely to the hospital with severe epigastric pain that is radiating to the back, nausea and vomiting. Upon questioning, she has suffered from several episodes of biliary colic in the past. A blood test reveals a lipase level of 1000U/L.
What is the underlying pathophysiology of Sophie's condition?Your Answer: An enormous release of pancreatic enzymes triggers a negative feedback mechanism, causes the pancreatic glands to stop producing pancreatic enzymes
Correct Answer: Pancreatic enzymes released as a result of inflammation autodigest the pancreatic tissue
Explanation:The cause of acute pancreatitis is the autodigestion of pancreatic tissue by pancreatic enzymes, which results in tissue necrosis. The patient is experiencing typical symptoms of acute pancreatitis, including epigastric pain that radiates to the back, nausea, and vomiting. The presence of elevated lipase levels, which are more than three times the upper limit of normal, is also indicative of acute pancreatitis. The patient’s history of biliary colic suggests that gallstones may be the underlying cause of this condition.
During acute pancreatitis, inflammation of the pancreas triggers the release and activation of pancreatic enzymes, which then begin to digest the pancreatic tissue. This process is known as autodigestion. Autodigestion of fat can lead to tissue necrosis, while autodigestion of blood vessels can cause retroperitoneal hemorrhage, which can be identified by the presence of Grey Turner’s sign and Cullen’s sign.
Understanding Acute Pancreatitis
Acute pancreatitis is a condition that is commonly caused by alcohol or gallstones. It occurs when the pancreatic enzymes start to digest the pancreatic tissue, leading to necrosis. The most common symptom of acute pancreatitis is severe epigastric pain that may radiate through to the back. Vomiting is also common, and examination may reveal epigastric tenderness, ileus, and low-grade fever. Although rare, periumbilical discolouration (Cullen’s sign) and flank discolouration (Grey-Turner’s sign) may also be present.
To diagnose acute pancreatitis, doctors typically measure the levels of serum amylase and lipase in the blood. While amylase is raised in 75% of patients, it does not correlate with disease severity. Lipase, on the other hand, is more sensitive and specific than amylase and has a longer half-life, making it useful for late presentations. Imaging, such as ultrasound or contrast-enhanced CT, may also be necessary to assess the aetiology of the condition.
Scoring systems, such as the Ranson score, Glasgow score, and APACHE II, are used to identify cases of severe pancreatitis that may require intensive care management. Factors indicating severe pancreatitis include age over 55 years, hypocalcaemia, hyperglycaemia, hypoxia, neutrophilia, and elevated LDH and AST. However, the actual amylase level is not of prognostic value.
In summary, acute pancreatitis is a condition that can cause severe pain and discomfort. It is important to diagnose and manage it promptly to prevent complications.
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This question is part of the following fields:
- Gastrointestinal System
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Question 185
Correct
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A 55-year-old man comes to the emergency department complaining of sudden abdominal pain in the epigastric region. He has a history of heavy alcohol consumption, but this is his first visit to the department. Upon examination, he is sweating profusely and has a fever. His heart rate is 130 beats per minute, and his blood pressure is 90/60 mmHg. You diagnose him with acute pancreatitis and are concerned about potential complications.
What symptom is most likely to be present in this patient?Your Answer: Blue discolouration of the flank regions
Explanation:The patient is experiencing acute pancreatitis, possibly due to excessive alcohol consumption. As this is his first visit to the emergency department, it is unlikely to be a sudden attack on top of chronic pancreatitis. The presence of tachycardia and hypotension suggests that he is also experiencing blood loss. The correct answer should identify an acute condition associated with blood loss.
a. Bulky, greasy stools are a long-term complication of chronic pancreatitis, indicating that the pancreas has lost its exocrine function and is unable to properly digest food.
b. Grey Turner’s sign is a sign of blood pooling in the retroperitoneal space, which can occur due to inflammation of the retroperitoneal pancreas.
c. This is a complication of long-term diabetes or chronic pancreatitis.
d. Ascites is not typically associated with an acute first-time presentation of pancreatitis, although it can have many causes.
e. This description is typical of an abdominal obstruction, which may cause nausea and vomiting.
The retroperitoneal structures are those that are located behind the peritoneum, which is the membrane that lines the abdominal cavity. These structures include the duodenum (2nd, 3rd, and 4th parts), ascending and descending colon, kidneys, ureters, aorta, and inferior vena cava. They are situated in the back of the abdominal cavity, close to the spine. In contrast, intraperitoneal structures are those that are located within the peritoneal cavity, such as the stomach, duodenum (1st part), jejunum, ileum, transverse colon, and sigmoid colon. It is important to note that the retroperitoneal structures are not well demonstrated in the diagram as the posterior aspect has been removed, but they are still significant in terms of their location and function.
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This question is part of the following fields:
- Gastrointestinal System
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Question 186
Incorrect
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You eagerly begin your second laparoscopic cholecystectomy and encounter unexpected difficulties with the anatomy of Calots triangle. While attempting to apply a haemostatic clip, you accidentally tear the cystic artery, resulting in profuse bleeding. What is the most probable source of this bleeding?
Your Answer: Gastroduodenal artery
Correct Answer: Right hepatic artery
Explanation:The most frequent scenario is for the cystic artery to originate from the right hepatic artery, although there are known variations in the anatomy of the gallbladder’s blood supply.
The gallbladder is a sac made of fibromuscular tissue that can hold up to 50 ml of fluid. Its lining is made up of columnar epithelium. The gallbladder is located in close proximity to various organs, including the liver, transverse colon, and the first part of the duodenum. It is covered by peritoneum and is situated between the right lobe and quadrate lobe of the liver. The gallbladder receives its arterial supply from the cystic artery, which is a branch of the right hepatic artery. Its venous drainage is directly to the liver, and its lymphatic drainage is through Lund’s node. The gallbladder is innervated by both sympathetic and parasympathetic nerves. The common bile duct originates from the confluence of the cystic and common hepatic ducts and is located in the hepatobiliary triangle, which is bordered by the common hepatic duct, cystic duct, and the inferior edge of the liver. The cystic artery is also found within this triangle.
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This question is part of the following fields:
- Gastrointestinal System
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Question 187
Incorrect
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A 44-year-old female presents to her GP with persistent gastro-oesophageal reflux disease and complains of a burning pain in her chest. She is referred to a gastroenterologist who performs an endoscopy with biopsy, leading to a diagnosis of Barrett's oesophagus. Explain the metaplasia that occurs in Barrett's oesophagus and its association with an increased risk of oesophageal cancer.
Barrett's oesophagus is characterized by the metaplasia of the lower oesophageal epithelium from stratified squamous to simple columnar epithelium. This change from the normal stratified squamous epithelium increases the risk of oesophageal cancer by 30-fold and is often caused by gastro-oesophageal reflux disease.Your Answer: Stratified squamous epithelium to simple cuboidal
Correct Answer: Stratified squamous epithelium to simple columnar
Explanation:Barrett’s oesophagus is characterized by the transformation of the lower oesophageal epithelial cells from stratified squamous to simple columnar epithelium. This change from the normal stratified squamous epithelium increases the risk of oesophageal cancer by 30 times and is often associated with gastro-oesophageal reflux disease.
Metaplasia is a reversible process where differentiated cells transform into another cell type. This change may occur as an adaptive response to stress, where cells sensitive to adverse conditions are replaced by more resilient cell types. Metaplasia can be a normal physiological response, such as the transformation of cartilage into bone. The most common type of epithelial metaplasia involves the conversion of columnar cells to squamous cells, which can be caused by smoking or Schistosomiasis. In contrast, metaplasia from squamous to columnar cells occurs in Barrett’s esophagus. If the metaplastic stimulus is removed, the cells will revert to their original differentiation pattern. However, if the stimulus persists, dysplasia may develop. Although metaplasia is not directly carcinogenic, factors that predispose to metaplasia may induce malignant transformation. The pathogenesis of metaplasia involves the reprogramming of stem cells or undifferentiated mesenchymal cells present in connective tissue, which differentiate along a new pathway.
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This question is part of the following fields:
- Gastrointestinal System
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Question 188
Correct
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Sarah presents to the Emergency Department with acute severe epigastric pain, nausea and vomiting following a holiday in Greece in which she consumed large amounts of alcohol. On investigation, she has a raised amylase of 500 IU/L and is diagnosed with acute pancreatitis. She is treated and makes a full recovery.
Eight weeks later she presents again, complaining of persisting moderately severe abdominal pain and early satiety. An ultrasound of her abdomen shows a fluid filled cavity in the pancreas lined with granulation tissue.
What complication of acute pancreatitis has Sarah developed?Your Answer: Pancreatic pseudocyst
Explanation:Alcohol intoxication is a common cause of acute pancreatitis, which can present with persistent abdominal pain and a fluid-filled cavity on ultrasound.
While a pancreatic tumor may also cause acute pancreatitis symptoms and obstructive jaundice, it would not typically show a fluid-filled cavity on ultrasound.
A pancreatic abscess, on the other hand, may present with signs of infection such as fever, rigors, and a tender mass.
Although diabetes can be a late complication of pancreatitis, it does not account for the ongoing abdominal pain or the presence of a fluid-filled cavity.
Complications of Acute Pancreatitis
Local complications of acute pancreatitis include peripancreatic fluid collections, pseudocysts, pancreatic necrosis, pancreatic abscess, and hemorrhage. Peripancreatic fluid collections occur in about 25% of cases and may resolve or develop into pseudocysts or abscesses. Pseudocysts are walled by fibrous or granulation tissue and typically occur 4 weeks or more after an attack of acute pancreatitis. Pancreatic necrosis may involve both the pancreatic parenchyma and surrounding fat, and complications are directly linked to the extent of necrosis. Pancreatic abscesses typically occur as a result of an infected pseudocyst. Hemorrhage may occur de novo or as a result of surgical necrosectomy and may be identified by Grey Turner’s sign when retroperitoneal hemorrhage occurs.
Systemic complications of acute pancreatitis include acute respiratory distress syndrome, which is associated with a high mortality rate of around 20%.
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This question is part of the following fields:
- Gastrointestinal System
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Question 189
Correct
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A 17-year-old girl comes to the emergency department complaining of nausea and vomiting. A medical trainee, who has recently started her emergency rotation, prescribes metoclopramide to alleviate her symptoms before ordering some tests.
The nurse cautions the doctor that metoclopramide is not recommended for young female patients and suggests switching to cyclizine.
What is the reason for metoclopramide being unsuitable for this patient?Your Answer: Risk of oculogyric crisis
Explanation:Metoclopramide use in children and young adults can lead to oculogyric crisis, which is a dystonic reaction that causes the eyes to involuntarily gaze upwards for an extended period. Opioids can cause respiratory depression, while cyclizine may result in restlessness and urinary retention. Amiodarone use may cause slate-grey skin discoloration. Additionally, metoclopramide can increase urinary frequency.
Understanding the Mechanism and Uses of Metoclopramide
Metoclopramide is a medication primarily used to manage nausea, but it also has other uses such as treating gastro-oesophageal reflux disease and gastroparesis secondary to diabetic neuropathy. It is often combined with analgesics for the treatment of migraines. However, it is important to note that metoclopramide has adverse effects such as extrapyramidal effects, acute dystonia, diarrhoea, hyperprolactinaemia, tardive dyskinesia, and parkinsonism. It should also be avoided in bowel obstruction but may be helpful in paralytic ileus.
The mechanism of action of metoclopramide is quite complicated. It is primarily a D2 receptor antagonist, but it also has mixed 5-HT3 receptor antagonist/5-HT4 receptor agonist activity. Its antiemetic action is due to its antagonist activity at D2 receptors in the chemoreceptor trigger zone, and at higher doses, the 5-HT3 receptor antagonist also has an effect. The gastroprokinetic activity is mediated by D2 receptor antagonist activity and 5-HT4 receptor agonist activity.
In summary, metoclopramide is a medication with multiple uses, but it also has adverse effects that should be considered. Its mechanism of action is complex, involving both D2 receptor antagonist and 5-HT3 receptor antagonist/5-HT4 receptor agonist activity. Understanding the uses and mechanism of action of metoclopramide is important for its safe and effective use.
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This question is part of the following fields:
- Gastrointestinal System
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Question 190
Correct
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A 36-year-old man is brought to the Emergency Department in an ambulance after being found unconscious by a friend. Shortly after arriving at the hospital, he becomes tachycardic, hypotensive, and stops breathing. The medical team suspects shock and examines him. What could be a potential cause of obstructive shock resulting from interference in ventricular filling?
Your Answer: Tension pneumothorax
Explanation:Shock can be caused by various factors, but only tension pneumothorax affects ventricular filling. Distributive shock, such as anaphylactic shock, hypovolaemic shock caused by chemical burns, and cardiogenic shock resulting from myocardial infarction are other examples. Obstructive shock caused by pulmonary embolism interferes with ventricular emptying, not filling.
Shock is a condition where there is not enough blood flow to the tissues. There are five main types of shock: septic, haemorrhagic, neurogenic, cardiogenic, and anaphylactic. Septic shock is caused by an infection that triggers a particular response in the body. Haemorrhagic shock is caused by blood loss, and there are four classes of haemorrhagic shock based on the amount of blood loss and associated symptoms. Neurogenic shock occurs when there is a disruption in the autonomic nervous system, leading to decreased vascular resistance and decreased cardiac output. Cardiogenic shock is caused by heart disease or direct myocardial trauma. Anaphylactic shock is a severe, life-threatening allergic reaction. Adrenaline is the most important drug in treating anaphylaxis and should be given as soon as possible.
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This question is part of the following fields:
- Gastrointestinal System
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Question 191
Incorrect
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Which one of the following structures is located most posteriorly at the porta hepatis?
Your Answer: Common hepatic artery
Correct Answer: Portal vein
Explanation:At the porta hepatis, the most posterior structure is the portal vein, while the common bile duct is created by the merging of the common hepatic duct and the cystic duct. The common hepatic duct extends and becomes the common bile duct.
Structure and Relations of the Liver
The liver is divided into four lobes: the right lobe, left lobe, quadrate lobe, and caudate lobe. The right lobe is supplied by the right hepatic artery and contains Couinaud segments V to VIII, while the left lobe is supplied by the left hepatic artery and contains Couinaud segments II to IV. The quadrate lobe is part of the right lobe anatomically but functionally is part of the left, and the caudate lobe is supplied by both right and left hepatic arteries and lies behind the plane of the porta hepatis. The liver lobules are separated by portal canals that contain the portal triad: the hepatic artery, portal vein, and tributary of bile duct.
The liver has various relations with other organs in the body. Anteriorly, it is related to the diaphragm, esophagus, xiphoid process, stomach, duodenum, hepatic flexure of colon, right kidney, gallbladder, and inferior vena cava. The porta hepatis is located on the postero-inferior surface of the liver and transmits the common hepatic duct, hepatic artery, portal vein, sympathetic and parasympathetic nerve fibers, and lymphatic drainage of the liver and nodes.
The liver is supported by ligaments, including the falciform ligament, which is a two-layer fold of peritoneum from the umbilicus to the anterior liver surface and contains the ligamentum teres (remnant of the umbilical vein). The ligamentum venosum is a remnant of the ductus venosus. The liver is supplied by the hepatic artery and drained by the hepatic veins and portal vein. Its nervous supply comes from the sympathetic and parasympathetic trunks of the coeliac plexus.
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This question is part of the following fields:
- Gastrointestinal System
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Question 192
Correct
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A 65-year-old man presents to the emergency department with a two-day history of rectal bleeding. He has had diarrhoea eight times in the past 24 hours with visible blood mixed with stool. He also complains of nausea and abdominal pain. His past medical history includes ulcerative colitis, hypertension and type 2 diabetes. He is currently taking mesalazine enteric coated 800 mg twice daily, amlodipine 10mg once daily and metformin 500mg twice daily.
Upon examination, he appears pale and has a temperature of 38ºC. His heart rate is 108/min with a blood pressure of 112/74mmHg. Abdominal exam shows generalised tenderness and guarding, but no rebound tenderness. His blood results are as follows:
- Hb 137 g/L Male: (135-180)
- Platelets 550 * 109/L (150 - 400)
- WBC 14.1 * 109/L (4.0 - 11.0)
- Na+ 144 mmol/L (135 - 145)
- K+ 3.4 mmol/L (3.5 - 5.0)
- Urea 8.4 mmol/L (2.0 - 7.0)
- Creatinine 134 µmol/L (55 - 120)
- CRP 110 mg/L (< 5)
- ESR 45 mm/hr Men: < (age / 2)
What is the most appropriate next step in managing this patient?Your Answer: Urgent hospital admission
Explanation:A severe flare-up of ulcerative colitis necessitates urgent hospital admission for IV corticosteroids. This is the correct answer as the patient’s symptoms indicate a severe flare-up according to Truelove and Witts’ severity index. The patient is experiencing more than 6 bowel movements per day with systemic upset (fever and tachycardia) and an ESR of over 30. NICE recommends urgent hospital admission for assessment and treatment with IV corticosteroids.
If the exacerbation is mild or moderate, oral corticosteroids may be appropriate. Therefore, send home with a course of oral corticosteroids is an incorrect answer.
Gastroenteritis requires oral rehydration therapy, but this patient’s symptoms suggest an exacerbation of ulcerative colitis. Therefore, oral rehydration therapy is an incorrect answer.
Loperamide may be used in the management of ulcerative colitis, but urgent hospital assessment is necessary due to the patient’s hemodynamic compromise. Therefore, send home with loperamide and send home with safety net advice alone are incorrect answers.
Ulcerative colitis can be managed through inducing and maintaining remission. The severity of the condition is classified as mild, moderate, or severe based on the number of stools per day, the amount of blood, and the presence of systemic upset. Treatment for mild-to-moderate cases of proctitis involves using topical aminosalicylate, while proctosigmoiditis and left-sided ulcerative colitis may require a combination of oral and topical medications. Severe cases should be treated in a hospital setting with intravenous steroids or ciclosporin.
To maintain remission, patients with proctitis and proctosigmoiditis may use topical aminosalicylate alone or in combination with an oral aminosalicylate. Those with left-sided and extensive ulcerative colitis may require a low maintenance dose of an oral aminosalicylate. Patients who have experienced severe relapses or multiple exacerbations may benefit from oral azathioprine or mercaptopurine. Methotrexate is not recommended for UC management, but probiotics may help prevent relapse in mild to moderate cases.
In summary, the management of ulcerative colitis involves a combination of inducing and maintaining remission. Treatment options vary depending on the severity and location of the condition, with mild-to-moderate cases typically treated with topical aminosalicylate and severe cases requiring hospitalization and intravenous medication. Maintaining remission may involve using a combination of oral and topical medications or a low maintenance dose of an oral aminosalicylate. While methotrexate is not recommended, probiotics may be helpful in preventing relapse in mild to moderate cases.
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This question is part of the following fields:
- Gastrointestinal System
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Question 193
Correct
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Which one of the following options in relation to the liver is true for individuals?
Your Answer: The caudate lobe is superior to the porta hepatis
Explanation:The ligamentum venosum and caudate lobe are located on the same side as the posterior vena cava. Positioned behind the liver, the ligamentum venosum is situated in the portal triad, which includes the portal vein (not the hepatic vein). The coronary ligament layers create a bare area of the liver, leaving a void. Additionally, the porta hepatis contains both sympathetic and parasympathetic nerves.
Structure and Relations of the Liver
The liver is divided into four lobes: the right lobe, left lobe, quadrate lobe, and caudate lobe. The right lobe is supplied by the right hepatic artery and contains Couinaud segments V to VIII, while the left lobe is supplied by the left hepatic artery and contains Couinaud segments II to IV. The quadrate lobe is part of the right lobe anatomically but functionally is part of the left, and the caudate lobe is supplied by both right and left hepatic arteries and lies behind the plane of the porta hepatis. The liver lobules are separated by portal canals that contain the portal triad: the hepatic artery, portal vein, and tributary of bile duct.
The liver has various relations with other organs in the body. Anteriorly, it is related to the diaphragm, esophagus, xiphoid process, stomach, duodenum, hepatic flexure of colon, right kidney, gallbladder, and inferior vena cava. The porta hepatis is located on the postero-inferior surface of the liver and transmits the common hepatic duct, hepatic artery, portal vein, sympathetic and parasympathetic nerve fibers, and lymphatic drainage of the liver and nodes.
The liver is supported by ligaments, including the falciform ligament, which is a two-layer fold of peritoneum from the umbilicus to the anterior liver surface and contains the ligamentum teres (remnant of the umbilical vein). The ligamentum venosum is a remnant of the ductus venosus. The liver is supplied by the hepatic artery and drained by the hepatic veins and portal vein. Its nervous supply comes from the sympathetic and parasympathetic trunks of the coeliac plexus.
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This question is part of the following fields:
- Gastrointestinal System
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Question 194
Incorrect
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A 53-year-old man visits his doctor complaining of heartburn. It occurs after meals and is not related to physical activity. He is a heavy drinker, consuming around 20 units of alcohol per week, and has been smoking 2 packs of cigarettes per day since he was 20 years old. He denies experiencing weight loss, melaena, haematemesis, or dysphagia.
The doctor prescribes ranitidine as an alternative to omeprazole. What is a true statement about ranitidine?Your Answer: Is a competitive agonist of H2 receptors on gastric parietal cells
Correct Answer: Is a competitive antagonist of H2 receptors on gastric parietal cells
Explanation:Ranitidine competes with histamine for binding to H2 receptors on gastric parietal cells, acting as an antagonist. It is not associated with sexual disinhibition, but can cause sexual dysfunction such as decreased libido and impotence. When the stomach pH drops too low, somatostatin secretion is stimulated, which inhibits acid secretion by parietal cells and also suppresses the release of positive regulators like histamine and gastrin. Ranitidine enhances the function of somatostatin rather than inhibiting it. As a result, it suppresses both normal and meal-stimulated acid secretion by parietal cells, making the third and fourth options incorrect.
Histamine-2 Receptor Antagonists and their Withdrawal from the Market
Histamine-2 (H2) receptor antagonists are medications used to treat dyspepsia, which includes conditions such as gastritis and gastro-oesophageal reflux disease. They were previously considered a first-line treatment option, but have since been replaced by more effective proton pump inhibitors. One example of an H2 receptor antagonist is ranitidine.
However, in 2020, ranitidine was withdrawn from the market due to the discovery of small amounts of the carcinogen N-nitrosodimethylamine (NDMA) in products from multiple manufacturers. This led to concerns about the safety of the medication and its potential to cause cancer. As a result, patients who were taking ranitidine were advised to speak with their healthcare provider about alternative treatment options.
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This question is part of the following fields:
- Gastrointestinal System
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Question 195
Incorrect
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A 75-year-old woman with caecal carcinoma is having a right hemicolectomy done via a transverse incision. During the procedure, the incision is extended medially by dividing the rectus sheath, and a brisk arterial hemorrhage occurs. What vessel is the source of the damage?
Your Answer: Internal iliac artery
Correct Answer: External iliac artery
Explanation:The damaged vessel is the epigastric artery, which has its origin in the external iliac artery (as shown below).
The Inferior Epigastric Artery: Origin and Pathway
The inferior epigastric artery is a blood vessel that originates from the external iliac artery just above the inguinal ligament. It runs along the medial edge of the deep inguinal ring and then continues upwards to lie behind the rectus abdominis muscle. This artery is responsible for supplying blood to the lower abdominal wall and pelvic region. Its pathway is illustrated in the image below.
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This question is part of the following fields:
- Gastrointestinal System
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Question 196
Correct
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A 57-year-old man underwent a terminal ileum resection for his Crohn's disease. After two months, he reports having pale and bulky stools. During his visit to the gastroenterology clinic, he was diagnosed with a deficiency in vitamin A. What could be the reason for his steatorrhoea and vitamin deficiency?
Your Answer: Bile acid malabsorption
Explanation:Steatorrhoea and Vitamin A, D, E, K malabsorption can result from bile acid malabsorption.
The receptors in the terminal ileum that are responsible for bile acid reabsorption are crucial for the enterohepatic circulation of bile acids. When these receptors are lost, the digestion and absorption of fat and fat-soluble vitamins are reduced, leading to steatorrhoea and vitamin A deficiency.
While hepatopancreatobiliary cancer can cause pale stools due to decreased stercobilinogen, it does not result in steatorrhoea or vitamin A deficiency.
Reduced intake of fat or vitamin A is not a cause of steatorrhoea.
Understanding Bile-Acid Malabsorption
Bile-acid malabsorption is a condition that can cause chronic diarrhea. It can be primary, which means that it is caused by excessive production of bile acid, or secondary, which is due to an underlying gastrointestinal disorder that reduces bile acid absorption. This condition can lead to steatorrhea and malabsorption of vitamins A, D, E, and K.
Secondary causes of bile-acid malabsorption are often seen in patients with ileal disease, such as Crohn’s disease. Other secondary causes include coeliac disease, small intestinal bacterial overgrowth, and cholecystectomy.
To diagnose bile-acid malabsorption, the test of choice is SeHCAT, which is a nuclear medicine test that uses a gamma-emitting selenium molecule in selenium homocholic acid taurine or tauroselcholic acid. Scans are done 7 days apart to assess the retention or loss of radiolabeled 75SeHCAT.
The management of bile-acid malabsorption involves the use of bile acid sequestrants, such as cholestyramine. These medications can help to bind bile acids in the intestine, reducing their concentration and improving symptoms. With proper management, individuals with bile-acid malabsorption can experience relief from their symptoms and improve their quality of life.
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This question is part of the following fields:
- Gastrointestinal System
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Question 197
Correct
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Which one of the following is not well absorbed after a gastrectomy?
Your Answer: Vitamin B12
Explanation:The absorption of Vitamin B12 is affected by post gastrectomy syndrome, while the absorption of other vitamins remains unaffected. This syndrome is characterized by the rapid emptying of food from the stomach into the duodenum, leading to symptoms such as abdominal pain, diarrhoea, and hypoglycaemia. Complications of this syndrome include malabsorption of Vitamin B12 and iron, as well as osteoporosis. Treatment involves following a diet that is high in protein and low in carbohydrates, and replacing any deficiencies in Vitamin B12, iron, and calcium.
Understanding Gastric Emptying and Its Controlling Factors
The stomach plays a crucial role in both mechanical and immunological functions. It retains solid and liquid materials, which undergo peristaltic activity against a closed pyloric sphincter, leading to fragmentation of food bolus material. Gastric acid helps neutralize any pathogens present. The time material spends in the stomach depends on its composition and volume, with amino acids and fat delaying gastric emptying.
Gastric emptying is controlled by neuronal stimulation mediated via the vagus and the parasympathetic nervous system, which favors an increase in gastric motility. Hormonal factors such as gastric inhibitory peptide, cholecystokinin, and enteroglucagon also play a role in delaying or increasing gastric emptying.
Diseases affecting gastric emptying can lead to bacterial overgrowth, retained food, and the formation of bezoars that may occlude the pylorus and worsen gastric emptying. Gastric surgery can also have profound effects on gastric emptying, with vagal disruption causing delayed emptying.
Diabetic gastroparesis is predominantly due to neuropathy affecting the vagus nerve, leading to poor stomach emptying and repeated vomiting. Malignancies such as distal gastric cancer and pancreatic cancer may also obstruct the pylorus and delay emptying. Congenital hypertrophic pyloric stenosis is a disease of infancy that presents with projectile non-bile stained vomiting and is treated with pyloromyotomy.
In summary, understanding gastric emptying and its controlling factors is crucial in diagnosing and treating various diseases that affect the stomach’s function.
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This question is part of the following fields:
- Gastrointestinal System
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Question 198
Correct
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A 56-year-old female patient who underwent tubal ligation presents to her general practitioner with complaints of abdominal pain, flank pain, visible blood in her urine, and involuntary urinary leakage. She has a history of lithotripsy for renal calculi one year ago. A CT scan of her abdomen and pelvis reveals an intra-abdominal fluid collection. What is the most probable diagnosis?
Your Answer: Ureter injury
Explanation:The patient’s symptoms and CT findings suggest that they may have suffered iatrogenic damage to their ureters, which are retroperitoneal organs. This can lead to fluid accumulation in the retroperitoneal space, causing haematuria, abdominal/flank pain, and incontinence. While calculi and lithotripsy can damage the ureter mucosal lining, they are unlikely to have caused fluid accumulation in the intra-abdominal cavity, especially since the lithotripsy was performed a year ago. Pelvic inflammatory disease and urinary tract infections can cause similar symptoms, but their CT findings would be different.
The retroperitoneal structures are those that are located behind the peritoneum, which is the membrane that lines the abdominal cavity. These structures include the duodenum (2nd, 3rd, and 4th parts), ascending and descending colon, kidneys, ureters, aorta, and inferior vena cava. They are situated in the back of the abdominal cavity, close to the spine. In contrast, intraperitoneal structures are those that are located within the peritoneal cavity, such as the stomach, duodenum (1st part), jejunum, ileum, transverse colon, and sigmoid colon. It is important to note that the retroperitoneal structures are not well demonstrated in the diagram as the posterior aspect has been removed, but they are still significant in terms of their location and function.
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This question is part of the following fields:
- Gastrointestinal System
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Question 199
Incorrect
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A 57-year-old woman is scheduled for a left hemicolectomy to treat splenic flexure carcinoma. The surgical team plans to perform a high ligation of the inferior mesenteric vein. Typically, what does this structure drain into?
Your Answer: Portal vein
Correct Answer: Splenic vein
Explanation:Colonic surgery carries the risk of ureteric injury, which should be taken into consideration.
Ileus can be caused during surgery when the inferior mesenteric vein joins the splenic vein near the duodenum, which is a known complication.
Anatomy of the Left Colon
The left colon is a part of the large intestine that passes inferiorly and becomes extraperitoneal in its posterior aspect. It is closely related to the ureter and gonadal vessels, which may be affected by disease processes. At a certain level, the left colon becomes the sigmoid colon, which is wholly intraperitoneal once again. The sigmoid colon is highly mobile and may even be found on the right side of the abdomen. As it passes towards the midline, the taenia blend marks the transition between the sigmoid colon and upper rectum.
The blood supply of the left colon comes from the inferior mesenteric artery. However, the marginal artery, which comes from the right colon, also contributes significantly. This contribution becomes clinically significant when the inferior mesenteric artery is divided surgically, such as during an abdominal aortic aneurysm repair. Understanding the anatomy of the left colon is important for diagnosing and treating diseases that affect this part of the large intestine.
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This question is part of the following fields:
- Gastrointestinal System
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Question 200
Correct
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A 63-year-old male presents to his GP with a complaint of blood in his stools. The blood is bright red and occurs during defecation, but it is not painful. He has been feeling more tired lately, but he has not experienced night sweats, weight loss, loss of appetite, or changes in bowel habits.
The patient has a history of liver cirrhosis and underwent an oesophageal endoscopy two years ago, but he cannot recall the results. He is a known alcoholic and attends AA.
Upon examination, the patient appears pale with conjunctival pallor, and ascites is present.
What is the most likely diagnosis?Your Answer: Haemorrhoids
Explanation:Haemorrhoids in Portal Hypertension
A likely diagnosis for a patient with a history of portal hypertension, ascites, endoscopy, and cirrhotic liver is haemorrhoids. Portal hypertension causes pressure to be passed on to the middle and inferior rectal veins, leading to their dilation and the development of haemorrhoids. While haemorrhoids are common in the general population, significant blood loss is rare. However, in patients with established cirrhosis, large amounts of blood can be lost through these varices.
An anal fissure is unlikely in this case, as there is no history of straining or a low-fibre diet, and they are typically painful. While colorectal carcinoma is an important diagnosis to consider, painless bright fresh blood is more likely to be caused by haemorrhoids in patients with a strong history of portal hypertension. In malignancy, fresh blood is less common, and a change in bowel habit is often a prominent feature.
A perianal haematoma is a thrombosed haemorrhoid that typically presents with severe pain, making it an unlikely diagnosis in this case. The patient’s presentation of painless bleeding further supports the diagnosis of haemorrhoids in the context of portal hypertension.
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This question is part of the following fields:
- Gastrointestinal System
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