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Question 1
Incorrect
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A 15-year-old girl comes to the clinic with her father. She has lost 10kg in the last 2 months. Recently, her father found her vomiting in the bathroom. The girl admits to struggling with her self-esteem and body image, and has been inducing vomiting after meals. She feels anxious in social situations. During the examination, you observe swelling above the angle of the mandible, indicating parotid gland enlargement. Which nerve supplies the parasympathetic fibers to the parotid gland?
Your Answer: Mandibular nerve
Correct Answer: Glossopharyngeal nerve
Explanation:The correct answer is the glossopharyngeal nerve, which is the ninth cranial nerve. It provides parasympathetic innervation to the parotid gland and carries taste and sensation from the posterior third of the tongue, pharyngeal wall, tonsils, middle ear, external auditory canal, and auricle. It also supplies baroreceptors and chemoreceptors of the carotid sinus.
The facial nerve, the seventh cranial nerve, supplies the muscles of facial expression, taste from the anterior two-thirds of the tongue, and sensation from parts of the external acoustic meatus, auricle, and retro-auricular area. It also provides parasympathetic fibers to the submandibular gland, sublingual gland, nasal glands, and lacrimal glands.
The hypoglossal nerve, the twelfth cranial nerve, supplies the intrinsic muscles of the tongue and all but one of the extrinsic muscles of the tongue.
The greater auricular nerve is a superficial cutaneous branch of the cervical plexus that supplies sensation to the capsule of the parotid gland, skin overlying the gland, and skin over the mastoid process and outer ear.
The mandibular nerve, the third division of the trigeminal nerve, carries sensory and motor fibers. It carries sensation from the lower lip, lower teeth and gingivae, chin, and jaw. It also supplies motor innervation to the muscles of mastication, mylohyoid, the anterior belly of digastric, tensor veli palatini, and tensor tympani.
The patient in the question has sialadenosis, a benign, non-inflammatory enlargement of a salivary gland, in the parotid glands, which can be caused by bulimia nervosa.
The parotid gland is located in front of and below the ear, overlying the mandibular ramus. Its salivary duct crosses the masseter muscle, pierces the buccinator muscle, and drains adjacent to the second upper molar tooth. The gland is traversed by several structures, including the facial nerve, external carotid artery, retromandibular vein, and auriculotemporal nerve. The gland is related to the masseter muscle, medial pterygoid muscle, superficial temporal and maxillary artery, facial nerve, stylomandibular ligament, posterior belly of the digastric muscle, sternocleidomastoid muscle, stylohyoid muscle, internal carotid artery, mastoid process, and styloid process. The gland is supplied by branches of the external carotid artery and drained by the retromandibular vein. Its lymphatic drainage is to the deep cervical nodes. The gland is innervated by the parasympathetic-secretomotor, sympathetic-superior cervical ganglion, and sensory-greater auricular nerve. Parasympathetic stimulation produces a water-rich, serous saliva, while sympathetic stimulation leads to the production of a low volume, enzyme-rich saliva.
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This question is part of the following fields:
- Gastrointestinal System
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Question 2
Correct
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A 56-year-old male patient comes to the clinic with a history of dyspepsia that he has ignored for a long time. He reports no symptoms of dysphagia or haematemesis. During an oesophagoduodenoscopy (OGD), mucosal changes are observed in the lower part of the oesophagus near the sphincter, and a biopsy is taken from this area. What is the probable result of the biopsy?
Your Answer: Columnar epithelial cells
Explanation:The patient has Barrett’s oesophagus, which is a metaplastic condition where the normal oesophageal epithelium is replaced by columnar cells. This increases the risk of adenocarcinoma.
Barrett’s oesophagus is a condition where the lower oesophageal mucosa is replaced by columnar epithelium, which increases the risk of oesophageal adenocarcinoma by 50-100 fold. It is usually identified during an endoscopy for upper gastrointestinal symptoms such as dyspepsia, as there are no screening programs for it. The length of the affected segment determines the chances of identifying metaplasia, with short (<3 cm) and long (>3 cm) subtypes. The prevalence of Barrett’s oesophagus is estimated to be around 1 in 20, and it is identified in up to 12% of those undergoing endoscopy for reflux.
The columnar epithelium in Barrett’s oesophagus may resemble that of the cardiac region of the stomach or that of the small intestine, with goblet cells and brush border. The single strongest risk factor for Barrett’s oesophagus is gastro-oesophageal reflux disease (GORD), followed by male gender, smoking, and central obesity. Alcohol is not an independent risk factor for Barrett’s, but it is associated with both GORD and oesophageal cancer. Patients with Barrett’s oesophagus often have coexistent GORD symptoms.
The management of Barrett’s oesophagus involves high-dose proton pump inhibitor, although the evidence base for its effectiveness in reducing the progression to dysplasia or inducing regression of the lesion is limited. Endoscopic surveillance with biopsies is recommended every 3-5 years for patients with metaplasia but not dysplasia. If dysplasia of any grade is identified, endoscopic intervention is offered, such as radiofrequency ablation, which is the preferred first-line treatment, particularly for low-grade dysplasia, or endoscopic mucosal resection.
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This question is part of the following fields:
- Gastrointestinal System
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Question 3
Correct
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A 53-year-old man visits his doctor complaining of heartburn. It occurs after meals and is not related to physical activity. He is a heavy drinker, consuming around 20 units of alcohol per week, and has been smoking 2 packs of cigarettes per day since he was 20 years old. He denies experiencing weight loss, melaena, haematemesis, or dysphagia.
The doctor prescribes ranitidine as an alternative to omeprazole. What is a true statement about ranitidine?Your Answer: Is a competitive antagonist of H2 receptors on gastric parietal cells
Explanation:Ranitidine competes with histamine for binding to H2 receptors on gastric parietal cells, acting as an antagonist. It is not associated with sexual disinhibition, but can cause sexual dysfunction such as decreased libido and impotence. When the stomach pH drops too low, somatostatin secretion is stimulated, which inhibits acid secretion by parietal cells and also suppresses the release of positive regulators like histamine and gastrin. Ranitidine enhances the function of somatostatin rather than inhibiting it. As a result, it suppresses both normal and meal-stimulated acid secretion by parietal cells, making the third and fourth options incorrect.
Histamine-2 Receptor Antagonists and their Withdrawal from the Market
Histamine-2 (H2) receptor antagonists are medications used to treat dyspepsia, which includes conditions such as gastritis and gastro-oesophageal reflux disease. They were previously considered a first-line treatment option, but have since been replaced by more effective proton pump inhibitors. One example of an H2 receptor antagonist is ranitidine.
However, in 2020, ranitidine was withdrawn from the market due to the discovery of small amounts of the carcinogen N-nitrosodimethylamine (NDMA) in products from multiple manufacturers. This led to concerns about the safety of the medication and its potential to cause cancer. As a result, patients who were taking ranitidine were advised to speak with their healthcare provider about alternative treatment options.
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This question is part of the following fields:
- Gastrointestinal System
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Question 4
Incorrect
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A 20-year-old man presents to the gastroenterology clinic with a 5-month history of abdominal pain and diarrhoea. He reports passing fresh red blood in his stool and having up to 7 bowel movements a day in the last month. He has lost 6kg in weight over the last 5 months.
The patient is referred for various investigations.
What finding would support the probable diagnosis?Your Answer: Transmural inflammation
Correct Answer: Goblet cell depletion
Explanation:Crohn’s disease has the potential to impact any section of the digestive system, including the oral mucosa and peri-anal region. It is common for there to be healthy areas of bowel in between the inflamed segments. The disease is characterized by deep ulceration in the gut mucosa, with skip lesions creating a distinctive cobblestone appearance during endoscopy.
Inflammatory bowel disease (IBD) is a condition that includes two main types: Crohn’s disease and ulcerative colitis. Although they share many similarities in terms of symptoms, diagnosis, and treatment, there are some key differences between the two. Crohn’s disease is characterized by non-bloody diarrhea, weight loss, upper gastrointestinal symptoms, mouth ulcers, perianal disease, and a palpable abdominal mass in the right iliac fossa. On the other hand, ulcerative colitis is characterized by bloody diarrhea, abdominal pain in the left lower quadrant, tenesmus, gallstones, and primary sclerosing cholangitis. Complications of Crohn’s disease include obstruction, fistula, and colorectal cancer, while ulcerative colitis has a higher risk of colorectal cancer than Crohn’s disease. Pathologically, Crohn’s disease lesions can be seen anywhere from the mouth to anus, while ulcerative colitis inflammation always starts at the rectum and never spreads beyond the ileocaecal valve. Endoscopy and radiology can help diagnose and differentiate between the two types of IBD.
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This question is part of the following fields:
- Gastrointestinal System
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Question 5
Correct
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A 54-year-old male presents to the emergency department with frank haematemesis. He is urgently resuscitated and undergoes an urgent oesophagogastroduodenoscopy (OGD), which reveals an active bleed in the distal part of the lesser curvature of the stomach. The bleed is successfully controlled with endoclips and adrenaline. The patient has a history of gastric ulcers. What is the most probable artery responsible for the bleeding?
Your Answer: Right gastric artery
Explanation:The distal lesser curvature of the stomach is supplied by the right gastric artery, while the proximal lesser curvature is supplied by the left gastric artery. The proximal greater curvature is supplied by the left gastroepiploic artery, and the distal greater curvature is supplied by the right gastroepiploic artery.
The Gastroduodenal Artery: Supply and Path
The gastroduodenal artery is responsible for supplying blood to the pylorus, proximal part of the duodenum, and indirectly to the pancreatic head through the anterior and posterior superior pancreaticoduodenal arteries. It commonly arises from the common hepatic artery of the coeliac trunk and terminates by bifurcating into the right gastroepiploic artery and the superior pancreaticoduodenal artery.
To better understand the relationship of the gastroduodenal artery to the first part of the duodenum, the stomach is reflected superiorly in an image sourced from Wikipedia. This artery plays a crucial role in providing oxygenated blood to the digestive system, ensuring proper functioning and health.
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This question is part of the following fields:
- Gastrointestinal System
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Question 6
Incorrect
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A 57-year-old man with a history of hyperlipidemia, hypertension, and type II diabetes presents to the emergency department with dull chest pain accompanied by sweating and nausea. He is promptly administered oxygen, aspirin, morphine, metoclopramide, atenolol, and nitrates.
Upon examination, angiography reveals significant blockage in all four coronary vessels. As a result, he is scheduled for an urgent coronary artery bypass graft, which will necessitate the removal of a vein from his lower limb.
Which nerve is most frequently affected during a vein harvest for CABG?Your Answer: Sciatic nerve
Correct Answer: Saphenous nerve
Explanation:During a coronary artery bypass graft (CABG), the great saphenous vein is often harvested. However, this procedure can lead to damage of the saphenous nerve, which runs closely alongside the vein in the medial aspect of the leg. Saphenous neuralgia, characterized by numbness, heightened sensitivity, and pain in the saphenous nerve distribution area, can result from such injury. Other nerves are not typically affected during a vein harvest for CABG.
During surgical procedures, there is a risk of nerve injury caused by the surgery itself. This is not only important for the patient’s well-being but also from a legal perspective. There are various operations that carry the risk of nerve damage, such as posterior triangle lymph node biopsy, Lloyd Davies stirrups, thyroidectomy, anterior resection of rectum, axillary node clearance, inguinal hernia surgery, varicose vein surgery, posterior approach to the hip, and carotid endarterectomy. Surgeons must have a good understanding of the anatomy of the area they are operating on to minimize the incidence of nerve lesions. Blind placement of haemostats is not recommended as it can also cause nerve damage.
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This question is part of the following fields:
- Gastrointestinal System
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Question 7
Correct
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A 67-year-old man presents to the emergency department after collapsing while shopping. He is experiencing profuse sweating and has a blood pressure of 98/63 mmHg. The patient reports severe epigastric pain as his only complaint.
The suspected cause of his symptoms is peptic ulcer disease, which may have caused erosion into a blood vessel. Upon endoscopy, a perforation is discovered in the posterior medial wall of the second part of the duodenum.
What is the most likely blood vessel that has been affected?Your Answer: Gastroduodenal artery
Explanation:The gastroduodenal artery is a potential source of significant gastrointestinal bleeding that can occur as a complication of peptic ulcer disease. The most likely diagnosis based on the given clinical information is peptic ulcer disease, which can cause the ulcer to penetrate through the posteromedial wall of the second part of the duodenum and into the gastroduodenal artery. This can result in a severe gastrointestinal bleed, leading to shock, which may present with symptoms such as low blood pressure, sweating, and collapse.
The answers Splenic artery, Left gastric artery, and Coeliac trunk are incorrect. The splenic artery runs behind the stomach and connects the coeliac trunk to the spleen, and does not pass near the second part of the duodenum. The left gastric artery runs along the small curvature of the stomach and supplies that region, and does not pass through the posteromedial wall of the duodenum. The coeliac trunk arises from the abdominal aorta at the level of T12 and gives rise to the splenic, left gastric, and common hepatic arteries, but does not lie near the second part of the duodenum.
Managing Acute Bleeding in Peptic Ulcer Disease
Peptic ulcer disease is a condition that can lead to acute bleeding, which is the most common complication of the disease. In fact, bleeding accounts for about three-quarters of all problems associated with peptic ulcer disease. The gastroduodenal artery is often the source of significant gastrointestinal bleeding in patients with this condition. The most common symptom of acute bleeding in peptic ulcer disease is haematemesis, but patients may also experience melaena, hypotension, and tachycardia.
When managing acute bleeding in peptic ulcer disease, an ABC approach should be taken, as with any upper gastrointestinal haemorrhage. Intravenous proton pump inhibitors are the first-line treatment, and endoscopic intervention is typically the preferred approach. However, if endoscopic intervention fails (which occurs in approximately 10% of patients), urgent interventional angiography with transarterial embolization or surgery may be necessary. By following these management strategies, healthcare providers can effectively address acute bleeding in patients with peptic ulcer disease.
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This question is part of the following fields:
- Gastrointestinal System
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Question 8
Correct
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A 25-year-old male patient visits his general practitioner complaining of abdominal pain, diarrhea, and painful aphthous ulcers that have been bothering him for the last four weeks. He has also observed that his clothes have become loose lately.
What is the typical disease pattern associated with his condition?Your Answer: Inflammation anywhere from the mouth to anus
Explanation:Crohn’s disease is characterized by inflammation that can occur anywhere from the mouth to the anus. This patient’s symptoms, including weight loss, abdominal pain, and diarrhea, suggest inflammatory bowel disease (IBD). The presence of mouth ulcers indicates Crohn’s disease, as it is known for causing discontinuous inflammation throughout the gastrointestinal tract. Ulcerative colitis, on the other hand, does not cause mouth ulcers and typically involves continuous inflammation that extends from the rectum. While colorectal polyposis can be a complication of IBD, it alone does not explain the patient’s symptoms. Ulcerative colitis is characterized by continuous inflammation that is limited to the submucosa and originates in the rectum, which is not the case for this patient.
Inflammatory bowel disease (IBD) is a condition that includes two main types: Crohn’s disease and ulcerative colitis. Although they share many similarities in terms of symptoms, diagnosis, and treatment, there are some key differences between the two. Crohn’s disease is characterized by non-bloody diarrhea, weight loss, upper gastrointestinal symptoms, mouth ulcers, perianal disease, and a palpable abdominal mass in the right iliac fossa. On the other hand, ulcerative colitis is characterized by bloody diarrhea, abdominal pain in the left lower quadrant, tenesmus, gallstones, and primary sclerosing cholangitis. Complications of Crohn’s disease include obstruction, fistula, and colorectal cancer, while ulcerative colitis has a higher risk of colorectal cancer than Crohn’s disease. Pathologically, Crohn’s disease lesions can be seen anywhere from the mouth to anus, while ulcerative colitis inflammation always starts at the rectum and never spreads beyond the ileocaecal valve. Endoscopy and radiology can help diagnose and differentiate between the two types of IBD.
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This question is part of the following fields:
- Gastrointestinal System
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Question 9
Incorrect
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A 45-year-old man complains of dyspepsia and is scheduled for an upper GI endoscopy. The procedure reveals diffuse gastric and duodenal ulcers. Upon conducting a Clo test, Helicobacter pylori infection is confirmed. What is the probable cause of the ulcers?
Your Answer: Increased urease activity
Correct Answer: Increased acid production
Explanation:H-Pylori is capable of causing both gastric and duodenal ulcers, but the mechanism behind this is not fully understood. One theory suggests that the organism induces gastric metaplasia in the duodenum by increasing acid levels. This metaplastic transformation is necessary for H-Pylori to colonize the duodenal mucosa and cause ulcers. Therefore, only individuals who have undergone this transformation are at risk for duodenal ulcers caused by H-Pylori.
Helicobacter pylori: A Bacteria Associated with Gastrointestinal Problems
Helicobacter pylori is a type of Gram-negative bacteria that is commonly associated with various gastrointestinal problems, particularly peptic ulcer disease. This bacterium has two primary mechanisms that allow it to survive in the acidic environment of the stomach. Firstly, it uses its flagella to move away from low pH areas and burrow into the mucous lining to reach the epithelial cells underneath. Secondly, it secretes urease, which converts urea to NH3, leading to an alkalinization of the acidic environment and increased bacterial survival.
The pathogenesis mechanism of Helicobacter pylori involves the release of bacterial cytotoxins, such as the CagA toxin, which can disrupt the gastric mucosa. This bacterium is associated with several gastrointestinal problems, including peptic ulcer disease, gastric cancer, B cell lymphoma of MALT tissue, and atrophic gastritis. However, its role in gastro-oesophageal reflux disease (GORD) is unclear, and there is currently no role for the eradication of Helicobacter pylori in GORD.
The management of Helicobacter pylori infection involves a 7-day course of treatment with a proton pump inhibitor, amoxicillin, and either clarithromycin or metronidazole. For patients who are allergic to penicillin, a proton pump inhibitor, metronidazole, and clarithromycin are used instead.
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This question is part of the following fields:
- Gastrointestinal System
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Question 10
Incorrect
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A 4-year-old boy is brought to the GP by his mother due to concerns about his growth and weight gain. The mother has noticed that her son is smaller than other children his age and has difficulty putting on weight. Additionally, she has observed that his stools have become pale and greasy, and he frequently experiences bloating. Upon examination, the boy appears underweight and pale, with abdominal distension and muscle wasting in the buttocks. Based on this history and examination, what is the most likely diagnosis?
Your Answer: Crohn's disease
Correct Answer: Coeliac disease
Explanation:Coeliac disease typically presents in children around the age when they start consuming wheat and cereal, but some individuals may not show symptoms until later in life. It is crucial for healthcare professionals to be able to identify this condition, both in clinical settings and for exams.
Coeliac Disease in Children: Causes, Symptoms, and Diagnosis
Coeliac disease is a condition that affects children and is caused by sensitivity to gluten, a protein found in cereals. This sensitivity leads to villous atrophy, which causes malabsorption. Children usually present with symptoms before the age of 3, coinciding with the introduction of cereals into their diet. The incidence of coeliac disease is around 1 in 100, and it is strongly associated with HLA-DQ2 and HLA-DQ8. Symptoms of coeliac disease include failure to thrive, diarrhoea, abdominal distension, and anaemia in older children. However, many cases are not diagnosed until adulthood.
Diagnosis of coeliac disease involves a jejunal biopsy showing subtotal villous atrophy, as well as screening tests for anti-endomysial and anti-gliadin antibodies. The biopsy shows complete atrophy of the villi with flat mucosa and marked crypt hyperplasia, as well as dense mixed inflammatory infiltrate in the lamina propria. Another biopsy may show flat mucosa with hyperplastic crypts and dense cellular infiltrate in the lamina propria, as well as an increased number of intraepithelial lymphocytes and vacuolated superficial epithelial cells. Overall, coeliac disease is a serious condition that requires early diagnosis and management to prevent long-term complications.
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This question is part of the following fields:
- Gastrointestinal System
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Question 11
Correct
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A 67-year-old male is receiving treatment for his colorectal cancer from the oncology team at his nearby hospital. What type of colorectal carcinoma is most frequently encountered?
Your Answer: Adenocarcinoma
Explanation:The most common type of colorectal cancer is adenocarcinoma, which originates from the mucosal lining of the colon. Initially, it develops as a benign adenoma from glandular cells of the mucosa, which later transforms into a malignant form.
Squamous cell carcinoma arises from squamous cells, which are not present in the colon. Ductal carcinoma is a breast cancer that originates from ductal cells. Basal cell carcinoma is a type of skin cancer, while mesothelioma is a malignancy that affects the mesothelium, commonly found in the lining of the chest wall.
Colorectal cancer is a prevalent type of cancer in the UK, ranking third in terms of frequency and second in terms of cancer-related deaths. Every year, approximately 150,000 new cases are diagnosed, and 50,000 people die from the disease. The cancer can occur in different parts of the colon, with the rectum being the most common location, accounting for 40% of cases. The sigmoid colon follows closely, with 30% of cases, while the descending colon has only 5%. The transverse colon has 10% of cases, and the ascending colon and caecum have 15%.
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This question is part of the following fields:
- Gastrointestinal System
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Question 12
Correct
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An 80-year-old man visits his GP complaining of indigestion that has persisted for the last three months. He has a medical history of hypertension and is a heavy smoker with a 50-pack-year history. He also consumes three glasses of wine on weeknights. Upon referral to a gastroenterologist, a lower oesophageal and stomach biopsy is performed, revealing metaplastic columnar epithelium. What is the primary factor that has contributed to the development of this histological finding?
Your Answer: Gastro-oesophageal reflux disease (GORD)
Explanation:Barrett’s oesophagus is diagnosed in this patient based on the presence of metaplastic columnar epithelium in the oesophageal epithelium. The most significant risk factor for the development of Barrett’s oesophagus is gastro-oesophageal reflux disease (GORD). While age is also a risk factor, it is not as strong as GORD. Alcohol consumption is not associated with Barrett’s oesophagus, but it is a risk factor for squamous cell oesophageal carcinoma. Infection with Helicobacter pylori is not linked to Barrett’s oesophagus, and it may even reduce the risk of GORD and Barrett’s oesophagus. Smoking is associated with both GORD and Barrett’s oesophagus, but the strength of this association is not as significant as that of GORD.
Barrett’s oesophagus is a condition where the lower oesophageal mucosa is replaced by columnar epithelium, which increases the risk of oesophageal adenocarcinoma by 50-100 fold. It is usually identified during an endoscopy for upper gastrointestinal symptoms such as dyspepsia, as there are no screening programs for it. The length of the affected segment determines the chances of identifying metaplasia, with short (<3 cm) and long (>3 cm) subtypes. The prevalence of Barrett’s oesophagus is estimated to be around 1 in 20, and it is identified in up to 12% of those undergoing endoscopy for reflux.
The columnar epithelium in Barrett’s oesophagus may resemble that of the cardiac region of the stomach or that of the small intestine, with goblet cells and brush border. The single strongest risk factor for Barrett’s oesophagus is gastro-oesophageal reflux disease (GORD), followed by male gender, smoking, and central obesity. Alcohol is not an independent risk factor for Barrett’s, but it is associated with both GORD and oesophageal cancer. Patients with Barrett’s oesophagus often have coexistent GORD symptoms.
The management of Barrett’s oesophagus involves high-dose proton pump inhibitor, although the evidence base for its effectiveness in reducing the progression to dysplasia or inducing regression of the lesion is limited. Endoscopic surveillance with biopsies is recommended every 3-5 years for patients with metaplasia but not dysplasia. If dysplasia of any grade is identified, endoscopic intervention is offered, such as radiofrequency ablation, which is the preferred first-line treatment, particularly for low-grade dysplasia, or endoscopic mucosal resection.
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This question is part of the following fields:
- Gastrointestinal System
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Question 13
Correct
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A 70-year-old woman visits her doctor as she has discovered a lump in her groin. She reports feeling well otherwise and has not experienced any changes in bowel movements or abdominal discomfort. The patient mentions that the lump tends to increase in size throughout the day, particularly when she is busy looking after her grandchildren. She has never undergone abdominal surgery. The doctor suspects a hernia and upon examination, identifies that it can be reduced and locates the hernia's neck, which is situated inferiorly and laterally to the pubic tubercle. What is the probable cause of the patient's groin lump?
Your Answer: Femoral hernia
Explanation:Femoral hernias are more prevalent in women than men, and their location at the neck of the hernia, which is inferior and lateral to the pubic tubercle, is indicative of a femoral hernia. On the other hand, an inguinal hernia would have its neck located superior and medial to the pubic tubercle, while both direct and indirect inguinal hernias share this characteristic. Since the patient has no surgical history, this cannot be an incisional hernia. A spigelian hernia, on the other hand, occurs when there is a herniation through the spigelian fascia, which is located along the semilunar line.
Understanding Inguinal Hernias
Inguinal hernias are the most common type of abdominal wall hernias, with 75% of cases falling under this category. They are more prevalent in men, with a 25% lifetime risk of developing one. The main symptom is a lump in the groin area, which disappears when pressure is applied or when the patient lies down. Discomfort and aching are also common, especially during physical activity. However, severe pain is rare, and strangulation is even rarer.
The traditional classification of inguinal hernias into indirect and direct types is no longer relevant in clinical management. Instead, the current consensus is to treat medically fit patients, even if they are asymptomatic. A hernia truss may be an option for those who are not fit for surgery, but it has limited use in other patients. Mesh repair is the preferred method, as it has the lowest recurrence rate. Unilateral hernias are usually repaired through an open approach, while bilateral and recurrent hernias are repaired laparoscopically.
After surgery, patients are advised to return to non-manual work after 2-3 weeks for open repair and 1-2 weeks for laparoscopic repair. Complications may include early bruising and wound infection, as well as late chronic pain and recurrence. It is important to seek medical attention if any of these symptoms occur.
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This question is part of the following fields:
- Gastrointestinal System
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Question 14
Correct
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A 25-year-old man was discovered collapsed outside a club on Saturday evening. According to his companion, he had consumed 10 pints of beer and began to retch. After an hour, he began to vomit blood. What is the medical diagnosis?
Your Answer: Mallory-Weiss tear
Explanation:Mallory-Weiss tears can be caused by repeated vomiting and are diagnosed through endoscopy.
Acute pancreatitis presents with severe upper abdominal pain and elevated serum amylase levels.
Coeliac disease causes diarrhoea, fatigue, and weight loss and is diagnosed through various tests.
Gastric carcinoma can cause non-specific symptoms in early stages and more severe symptoms in later stages.
Ulcerative colitis presents with bloody diarrhoea, weight loss, and rectal bleeding. -
This question is part of the following fields:
- Gastrointestinal System
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Question 15
Correct
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A 32-year-old man comes to you complaining of persistent diarrhoea for the past 10 days. He describes his diarrhoea as watery and foul-smelling, but denies any blood. He feels exhausted and asks for a prescription for an antidiarrhoeal medication. He has no notable medical history.
The stool cultures come back negative, and you contemplate starting the patient on diphenoxylate. Can you explain the mechanism of action of this drug?Your Answer: Inhibits peristalsis by acting on μ-opioid in the GI tract
Explanation:Diphenoxylate slows down peristalsis in the GI tract by acting on μ-opioid receptors.
Increased gut motility can be achieved through the positive cholinergic effect of muscarinic receptor activation.
All other options are inaccurate.
Antidiarrhoeal Agents: Opioid Agonists
Antidiarrhoeal agents are medications used to treat diarrhoea. Opioid agonists are a type of antidiarrhoeal agent that work by slowing down the movement of the intestines, which reduces the frequency and urgency of bowel movements. Two common opioid agonists used for this purpose are loperamide and diphenoxylate.
Loperamide is available over-the-counter and is often used to treat acute diarrhoea. It works by binding to opioid receptors in the intestines, which reduces the contractions of the muscles in the intestinal wall. This slows down the movement of food and waste through the intestines, allowing more time for water to be absorbed and resulting in firmer stools.
Diphenoxylate is a prescription medication that is often used to treat chronic diarrhoea. It works in a similar way to loperamide, but is often combined with atropine to discourage abuse and overdose.
Overall, opioid agonists are effective at treating diarrhoea, but should be used with caution and under the guidance of a healthcare professional. They can cause side effects such as constipation, dizziness, and nausea, and may interact with other medications.
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This question is part of the following fields:
- Gastrointestinal System
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Question 16
Incorrect
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A 30-year-old man is about to undergo a surgical procedure and is being catheterised. What changes will occur as the catheter enters his prostatic urethra?
Your Answer: Resistance will increase slightly
Correct Answer: Resistance will decrease
Explanation:The membranous urethra is narrower than the prostatic urethra, resulting in increased resistance. The prostatic urethra is angled vertically.
Anatomy of the Prostate Gland
The prostate gland is a small, walnut-shaped gland located below the bladder and separated from the rectum by Denonvilliers fascia. It receives its blood supply from the internal iliac vessels, specifically the inferior vesical artery. The gland has an internal sphincter at its apex, which can be damaged during surgery and result in retrograde ejaculation.
The prostate gland has four lobes: the posterior lobe, median lobe, and two lateral lobes. It also has an isthmus and three zones: the peripheral zone, central zone, and transition zone. The peripheral zone, which is the subcapsular portion of the posterior prostate, is where most prostate cancers occur.
The gland is surrounded by various structures, including the pubic symphysis, prostatic venous plexus, Denonvilliers fascia, rectum, ejaculatory ducts, lateral venous plexus, and levator ani. Its lymphatic drainage is to the internal iliac nodes, and its innervation comes from the inferior hypogastric plexus.
In summary, the prostate gland is a small but important gland in the male reproductive system. Its anatomy includes lobes, zones, and various surrounding structures, and it plays a crucial role in ejaculation and prostate health.
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This question is part of the following fields:
- Gastrointestinal System
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Question 17
Incorrect
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What is not considered a risk factor for the development of oesophageal cancer?
Your Answer: Achalasia
Correct Answer: Blood group O
Explanation:Oesophageal Cancer: Types, Risk Factors, Features, Diagnosis, and Treatment
Oesophageal cancer used to be mostly squamous cell carcinoma, but adenocarcinoma is now becoming more common, especially in patients with a history of gastro-oesophageal reflux disease (GORD) or Barrett’s. Adenocarcinoma is usually located near the gastroesophageal junction, while squamous cell tumours are found in the upper two-thirds of the oesophagus. The most common presenting symptom is dysphagia, followed by anorexia and weight loss, vomiting, and other possible features such as odynophagia, hoarseness, melaena, and cough.
To diagnose oesophageal cancer, upper GI endoscopy with biopsy is used, and endoscopic ultrasound is preferred for locoregional staging. CT scanning of the chest, abdomen, and pelvis is used for initial staging, and FDG-PET CT may be used for detecting occult metastases if metastases are not seen on the initial staging CT scans. Laparoscopy is sometimes performed to detect occult peritoneal disease.
Operable disease is best managed by surgical resection, with the most common procedure being an Ivor-Lewis type oesophagectomy. However, the biggest surgical challenge is anastomotic leak, which can result in mediastinitis. In addition to surgical resection, many patients will be treated with adjuvant chemotherapy.
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This question is part of the following fields:
- Gastrointestinal System
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Question 18
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A 4-year-old child is seen by a paediatrician for poor growth. The parents report that their child was previously at the 50th percentile for weight but has now dropped to the 10th percentile. The child also experiences multiple greasy and foul-smelling bowel movements daily.
During the evaluation, no structural cause for the child's growth failure is identified, and genetic testing is recommended. The results reveal a de-novo mutation that leads to the production of a truncated hormone responsible for promoting the secretion of bicarbonate-rich fluid in the pancreas.
Which hormone is most likely affected by this mutation?Your Answer: Cholecystokinin
Correct Answer: Secretin
Explanation:The correct answer is Secretin. Secretin is a hormone produced by the S cells in the duodenum that stimulates the release of bicarbonate-rich fluid from the pancreatic and hepatic duct cells. If the expression of secretin is not regulated properly, it can lead to malabsorption syndrome, which is similar to the symptoms experienced by the patient in the scenario.
Cholecystokinin is another hormone that is involved in the digestive process. It causes the gallbladder to contract, which results in the release of bile into the duodenum through the ampulla of Vater.
Gastrin is a hormone that stimulates the secretion of hydrochloric acid by the parietal cells in the stomach lining. It also promotes gastric motility.
Leptin is a hormone that is produced by adipose tissue and helps regulate appetite by promoting feelings of fullness. Genetic mutations that affect leptin signaling can lead to monogenic obesity.
Overview of Gastrointestinal Hormones
Gastrointestinal hormones play a crucial role in the digestion and absorption of food. These hormones are secreted by various cells in the stomach and small intestine in response to different stimuli such as the presence of food, pH changes, and neural signals.
One of the major hormones involved in food digestion is gastrin, which is secreted by G cells in the antrum of the stomach. Gastrin increases acid secretion by gastric parietal cells, stimulates the secretion of pepsinogen and intrinsic factor, and increases gastric motility. Another hormone, cholecystokinin (CCK), is secreted by I cells in the upper small intestine in response to partially digested proteins and triglycerides. CCK increases the secretion of enzyme-rich fluid from the pancreas, contraction of the gallbladder, and relaxation of the sphincter of Oddi. It also decreases gastric emptying and induces satiety.
Secretin is another hormone secreted by S cells in the upper small intestine in response to acidic chyme and fatty acids. Secretin increases the secretion of bicarbonate-rich fluid from the pancreas and hepatic duct cells, decreases gastric acid secretion, and has a trophic effect on pancreatic acinar cells. Vasoactive intestinal peptide (VIP) is a neural hormone that stimulates secretion by the pancreas and intestines and inhibits acid secretion.
Finally, somatostatin is secreted by D cells in the pancreas and stomach in response to fat, bile salts, and glucose in the intestinal lumen. Somatostatin decreases acid and pepsin secretion, decreases gastrin secretion, decreases pancreatic enzyme secretion, and decreases insulin and glucagon secretion. It also inhibits the trophic effects of gastrin and stimulates gastric mucous production.
In summary, gastrointestinal hormones play a crucial role in regulating the digestive process and maintaining homeostasis in the gastrointestinal tract.
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This question is part of the following fields:
- Gastrointestinal System
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Question 19
Incorrect
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A gynaecologist is performing a laparoscopic hysterectomy on a 45-year-old patient. He is being careful to avoid damaging a structure that runs close to the vaginal fornices.
What is the structure that the gynaecologist is most likely being cautious of?Your Answer: Ilioinguinal nerve
Correct Answer: Ureter
Explanation:The correct statements are:
– The ureter enters the bladder trigone after passing only 1 cm away from the vaginal fornices, which is closer than other structures.
– The ilioinguinal nerve originates from the first lumbar nerve (L1).
– The femoral artery is a continuation of the external iliac artery.
– The descending colon starts at the splenic flexure and ends at the beginning of the sigmoid colon.
– The obturator nerve arises from the ventral divisions of the second, third, and fourth lumbar nerves.Anatomy of the Ureter
The ureter is a muscular tube that measures 25-35 cm in length and is lined by transitional epithelium. It is surrounded by a thick muscular coat that becomes three muscular layers as it crosses the bony pelvis. This retroperitoneal structure overlies the transverse processes L2-L5 and lies anterior to the bifurcation of iliac vessels. The blood supply to the ureter is segmental and includes the renal artery, aortic branches, gonadal branches, common iliac, and internal iliac. It is important to note that the ureter lies beneath the uterine artery.
In summary, the ureter is a vital structure in the urinary system that plays a crucial role in transporting urine from the kidneys to the bladder. Its unique anatomy and blood supply make it a complex structure that requires careful consideration in any surgical or medical intervention.
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This question is part of the following fields:
- Gastrointestinal System
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Question 20
Correct
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An 80-year-old man comes to his doctor with a complaint of dysphagia that has been going on for three months. Initially, he could swallow some solid foods, but now he is only able to eat pureed foods. He has no difficulty swallowing liquids. He has a history of heavy smoking and alcohol consumption and is currently taking omeprazole for heartburn. He has lost a significant amount of weight due to his reduced caloric intake.
What is the likely cause of his dysphagia?Your Answer: There is likely a structural disorder of the oesophagus
Explanation:If a person has difficulty swallowing only solids, it is likely due to a structural disorder in the oesophagus such as cancer, strictures, or webs/rings. On the other hand, if they have difficulty swallowing both liquids and solids, it is probably due to a motility disorder in the oesophagus such as achalasia, scleroderma, or nutcracker oesophagus.
If the dysphagia is progressive, it may indicate cancer as the cause, as the ability to swallow foods that were previously manageable becomes increasingly difficult over time. Weight loss could also be a result of either cancer or reduced food intake.
It is important to note that although GORD can cause heartburn, it is not a likely cause of dysphagia.
Understanding Dysphagia and its Causes
Dysphagia, or difficulty in swallowing, can be caused by various conditions affecting the oesophagus, including cancer, oesophagitis, candidiasis, achalasia, pharyngeal pouch, systemic sclerosis, myasthenia gravis, and globus hystericus. These conditions have distinct features that can help in their diagnosis, such as weight loss and anorexia in oesophageal cancer, heartburn in oesophagitis, dysphagia of both liquids and solids in achalasia, and anxiety in globus hystericus. Dysphagia can also be classified as extrinsic, intrinsic, or neurological, depending on the underlying cause.
To diagnose dysphagia, patients usually undergo an upper GI endoscopy, a full blood count, and fluoroscopic swallowing studies. Additional tests, such as ambulatory oesophageal pH and manometry studies, may be needed for specific conditions. It’s important to note that new-onset dysphagia is a red flag symptom that requires urgent endoscopy, regardless of age or other symptoms. By understanding the causes and features of dysphagia, healthcare professionals can provide timely and appropriate management for their patients.
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This question is part of the following fields:
- Gastrointestinal System
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