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  • Question 1 - Which lobe of the prostate gland is most commonly affected in benign prostatic...

    Correct

    • Which lobe of the prostate gland is most commonly affected in benign prostatic hypertrophy?

      Your Answer: Median

      Explanation:

      Benign enlargement of the prostate is common in men older than 50 years. The cause is possibly an imbalance in the hormonal control of the gland. The median lobe of the gland enlarges upward and encroaches within the sphincter vesicae, located at the neck of the bladder. The leakage of urine into the prostatic urethra causes an intense reflex desire to micturate. The enlargement of the median and lateral lobes of the gland produces elongation and lateral compression and distortion of the urethra so that the patient experiences difficulty in passing urine and the stream is weak. Back-pressure effects on the ureters and both kidneys are a common complication. The enlargement of the uvula vesicae (owing to the enlarged median lobe) results in the formation of a pouch of stagnant urine behind the urethral orifice within the bladder. The stagnant urine frequently becomes infected, and the inflamed bladder (cystitis) adds to the patient’s symptoms.In all operations on the prostate, the surgeon regards the prostatic venous plexus with respect. The veins have thin walls, are valveless, and are drained by several large trunks directly into the internal iliac veins. Damage to these veins can result in a severe haemorrhage.

    • This question is part of the following fields:

      • Abdomen And Pelvis
      • Anatomy
      2.7
      Seconds
  • Question 2 - Which cervical interspace is most likely injured if a patient presents with difficulty...

    Correct

    • Which cervical interspace is most likely injured if a patient presents with difficulty of shoulder abduction and elbow flexion, pain in the right shoulder and lateral arm, and decreased sensation over the deltoid and lateral arm?

      Your Answer: C4-C5

      Explanation:

      In the setting of cervical radiculopathy, because the nerve root of a spinal nerve is compressed or otherwise impaired, the pain and symptomatology can spread far from the neck and radiates to arm, neck, chest, upper back and/or shoulders. Often muscle weakness and impaired deep tendon reflexes are noted along the course of the spinal nerve.Cervical radiculopathy is almost always unilateral, although, in rare cases, both nerves at a given level may be impacted. Those rare presentations can confound physical diagnosis and require acceleration to advanced imaging especially in cases of trauma. If there is nerve impingement, the affected side will be reduced relative to the unaffected side. Reduction in strength of muscles innervated by the affected nerve is also significant physical finding.For a C4-C5 injury, the following symptoms may present:Weakness in the deltoid muscle (front and side of the shoulder) and upper armShoulder painNumbness along the outside of the upper arm

    • This question is part of the following fields:

      • Anatomy
      • Head And Neck
      4.9
      Seconds
  • Question 3 - A 29 year old patient with known inflammatory bowel disease presents to ED...

    Correct

    • A 29 year old patient with known inflammatory bowel disease presents to ED with surgical complications following his recent ileocaecal resection. Removal of the terminal ileum may result in the malabsorption of which of the following:

      Your Answer: Vitamin B12

      Explanation:

      On ingestion, vitamin B12 is bound to R protein found in saliva and gastric secretions, which protects it from digestion in the stomach. Intrinsic factor is secreted by gastric parietal cells. Receptors for the IF-B12 complex are present in the membrane of epithelial cells of the terminal ileum, which bind the complex and allow uptake of vitamin B12 across the apical membrane by endocytosis. Vitamin B12 is then transported across the basal membrane into the portal blood where it is bound to transcobalamin II and processed by the liver. In pernicious anaemia, there are autoantibodies against gastric parietal cells and intrinsic factor, resulting in vitamin B12 deficiency anaemia.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      6
      Seconds
  • Question 4 - Which of the following statements is correct regarding paracetamol? ...

    Correct

    • Which of the following statements is correct regarding paracetamol?

      Your Answer: Liver damage peaks 3 to 4 days after paracetamol ingestion.

      Explanation:

      The maximum daily dose of paracetamol in an adult is 4 grams. Doses greater than this can lead to hepatotoxicity and, less frequently, acute kidney injury. Early symptoms of paracetamol toxicity include nausea, vomiting, and abdominal pain, and usually settle within 24 hours. Symptoms of liver damage include right subcostal pain and tenderness, and this peaks 3 to 4 days after paracetamol ingestion. Other signs of hepatic toxicity include encephalopathy, bleeding, hypoglycaemia, and cerebral oedema.

    • This question is part of the following fields:

      • Central Nervous System
      • Pharmacology
      5.2
      Seconds
  • Question 5 - What is the main route of transmission of Mumps? ...

    Correct

    • What is the main route of transmission of Mumps?

      Your Answer: Respiratory droplet route

      Explanation:

      Mumps is primarily transmitted person to person via respiratory droplets.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      2.4
      Seconds
  • Question 6 - Regarding nitrous oxide, which of the following statements is CORRECT: ...

    Correct

    • Regarding nitrous oxide, which of the following statements is CORRECT:

      Your Answer: Nitrous oxide may be used for maintenance of anaesthesia where its use allows reduced dosage of other agents.

      Explanation:

      For anaesthesia, nitrous oxide is commonly used in a concentration of around 50 – 66% in oxygen in association with other inhalation or intravenous agents. Nitrous oxide cannot be used as the sole anaesthetic agent due to lack of potency, but is useful as part of a combination of drugs since it allows reduction in dosage of other agents. Exposure to nitrous oxide for prolonged periods, either by continuous or by intermittent administration, may result in megaloblastic anaemia as a result of interference with the action of vitamin B12. Nitrous oxide increases cerebral blood flow and should be avoided in patients with, or at risk of, raised intracranial pressure. Nitrous oxide may be administered by any trained personnel experienced in its use.

    • This question is part of the following fields:

      • Anaesthesia
      • Pharmacology
      8.3
      Seconds
  • Question 7 - A 62-year-old woman presents with a 3-month history of lethargy and tiredness. She...

    Correct

    • A 62-year-old woman presents with a 3-month history of lethargy and tiredness. She states that she has also felt very itchy, particularly after a hot bath and that she is often dizzy and sweaty. On examination she appears plethoric and you note the presence of splenomegaly. Her blood tests today show that her haemoglobin level is 16.9 g/dl.What is the most likely diagnosis in this case? Select ONE answer only.

      Your Answer: Polycythaemia vera

      Explanation:

      Polycythaemia vera (PCV), which is also referred to as polycythaemia rubra vera, is a clonal haematological malignancy in which the bone marrow produces too many red blood cells. It may also result in the overproduction of white blood cells and platelets. It is most commonly seen in the elderly and the mean age at diagnosis is 65-74 years.Patients can be completely asymptomatic and it is often discovered as an incidental finding on a routine blood count. Approximately 1/3 of patients present with symptoms due to thrombosis, of these 3/4 have arterial thrombosis and 1/4 venous thrombosis. Features include stroke, myocardial infarction, deep vein thrombosis and pulmonary embolism.The other clinical features of PCV include:Plethoric appearanceLethargy and tirednessSplenomegaly (common)Pruritis (in 40% – particularly after exposure to hot water)Headaches, dizziness and sweating (in 30%)Gouty arthritis (in 20%)Budd-Chiari syndrome (in 5-10%)Erythromyalgia (in 18.5 g/dl in men, 16.5 g/dl in womenElevated red cell mass > 25% above mean normal predicted valuePresence of JAK2 mutationMinor criteria:Bone marrow biopsy showing hypercellularity with prominent erythroid, granulocytic and megakaryocytic proliferationSerum erythropoietin level below normal rangeEndogenous erythroid colony formation in vitroThe main aim of treatment is to normalize the full blood count and prevent complications such as thrombosis. Venesection is the treatment of choice but hydroxyurea can also be used to help control thrombocytosis.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      6.7
      Seconds
  • Question 8 - Regarding haemophilia A, which of the following statements is INCORRECT: ...

    Incorrect

    • Regarding haemophilia A, which of the following statements is INCORRECT:

      Your Answer: Haemophilia A is caused by a deficiency of factor VIII.

      Correct Answer: In haemophilia both the APTT and PT are prolonged.

      Explanation:

      Haemophilia A is the most common of the hereditary clotting factor deficiencies. The inheritance is sex-linked but up to one-third of patients have no family history and these cases result from recent mutation. The vast majority of cases are inherited in an X-linked recessive fashion, affecting males born to carrier mothers. Females born to affected fathers can also, rarely, be affected due to homozygosity for the gene, where there is marriage to close relatives. The defect is an absence or low level of plasma factor VIII. The APTT is prolonged but the PT is normal. Recurrent painful haemarthroses and muscle haematomas dominate the clinical course of severely affected patients and if inadequately treated, lead to progressive joint deformity and disability. Local pressure can cause entrapment neuropathy or ischaemic necrosis. Prolonged bleeding occurs after dental extractions or post-trauma. Spontaneous haematuria and gastrointestinal haemorrhage may occur. The clinical severity of the disease correlates inversely with the factor VIII level. Operative and post-traumatic haemorrhage are life-threatening both in severely and mildly affected patients.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      8.3
      Seconds
  • Question 9 - A 68-year-old female has presented to the Emergency Department with chest pain, palpitations,...

    Correct

    • A 68-year-old female has presented to the Emergency Department with chest pain, palpitations, and breathlessness complaints. On ECG, she is diagnosed with ventricular arrhythmia and is administered lidocaine. Which of the following is the correct mechanism of action of lidocaine?

      Your Answer: Blocks Na+ channels in the heart

      Explanation:

      Lidocaine is a tertiary amide local anaesthetic and also a class IV antiarrhythmic.Like other local anaesthetics, lidocaine works on the voltage-gated sodium ion channel on the nerve cell membranes. It works in the following steps:1. diffuses through neural sheaths and the axonal membrane into the axoplasm2. binds fast voltage-gated Na+ channels in the neuronal cell membrane and inactivates them3. With sufficient blockage, the membrane of the postsynaptic neuron will not depolarise and will be unable to transmit an action potential, thereby preventing the transmission of pain signalsThe same principle applies to Lidocaine’s actions in the heart as it blocks the sodium channels in the conduction system and the myocardium. This raises the threshold for depolarizing, making it less likely for the heart to initiate or conduct any action potential that can cause arrhythmia.

    • This question is part of the following fields:

      • Cardiovascular Pharmacology
      • Pharmacology
      9.8
      Seconds
  • Question 10 - Regarding Clostridium tetani, which of the following statements is CORRECT: ...

    Correct

    • Regarding Clostridium tetani, which of the following statements is CORRECT:

      Your Answer: Infection is predominantly derived from animal faeces and soil.

      Explanation:

      Clostridium tetaniis a Gram positive, rod shaped, obligate anaerobic bacterium.The incubation period is quoted as anywhere between 4-21 days and can occur after several months but symptoms usually occur within the first 7 days after exposure.Approximately 80% of patients develop generalised tetanus. The commonest presenting feature of generalised tetanus is trismus (lockjaw), occurring in approximately 75% of affected individuals. Other clinical features include:Facial spasms (risus sardonicus)Opisthotonus (characteristic body shape during spasms)Neck stiffnessDysphagiaCalf and pectoral muscle rigidityFeverHypertensionTachycardiaSpasms can occur frequently and last for several minutes, they can continue to occur for up to 4 weeks. Current mortality rates are between 10 and 15%.Tetanic spasms are caused by the exotoxin tetanospasmin. The effects of tetanolysin are not fully understood but it is not believed to have clinical significance.Localised tetanus is a rare form of the disease, occurring in around 1% of affected individuals. Patients have persistent contraction of muscles in the same anatomic area as the injury. It may precede generalised tetanus.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      9.2
      Seconds
  • Question 11 - Which of the following statements is incorrect regarding potassium replacement? ...

    Incorrect

    • Which of the following statements is incorrect regarding potassium replacement?

      Your Answer: Hypokalaemia predisposes to arrhythmias particularly in patients taking digoxin.

      Correct Answer: Oral potassium supplements are often required for patients taking spironolactone.

      Explanation:

      It is very seldom that potassium supplements are required with the small doses of diuretics given to treat hypertension. Potassium-sparing diuretics like spironolactone (rather than potassium supplements), are recommended for hypokalaemia prevention when diuretics are given to eliminate oedema, such as furosemide or the thiazides.

    • This question is part of the following fields:

      • Fluids And Electrolytes
      • Pharmacology
      12.8
      Seconds
  • Question 12 - A 59-year-old otherwise well woman presents with a history of polydipsia and polyuria....

    Correct

    • A 59-year-old otherwise well woman presents with a history of polydipsia and polyuria. There is a past history of kidney stones, and blood tests done reveal the following: Na: 147 mmol/L (135-147 mmol/L) K: 4.0 mmol/L (3.5-5.5 mmol/L) Urea: 7.3 mmol/L (2.0-6.6 mmol/L) Creatinine: 126 mmol/L (75-125 mmol/L) Fasting blood glucose: 5.0 mmol/L (3.4-5.5 mmol/L) Corrected calcium: 3.21 mmol/L (2.05-2.60 mmol/L) Phosphate: 0.70 mmol/L (0.8-1.4 mmol/L) Parathyroid hormone: 189 ng/L (10-60 ng/L)The most likely diagnosis is?

      Your Answer: Primary hyperparathyroidism

      Explanation:

      ​Primary hyperparathyroidism the commonest cause of hypercalcaemia. It is commonest in women aged 50 to 60.The commonest cause of primary hyperparathyroidism is a solitary adenoma of the parathyroid gland (approximately 85% of cases). Primary hyperparathyroidism may present with features of hypercalcaemia such as polyuria, polydipsia, renal stones, bone and joint pain, constipation, and psychiatric disorders.In primary Hyperparathyroidism:PTH is elevatedCalcium is elevatedPhosphate is loweredIn secondary Hyperparathyroidism:PTH is elevatedCalcium is low or low-normalPhosphate is raised in CRFIn tertiary Hyperparathyroidism:PTH is elevatedCalcium is elevatedPhosphate is lowered in CRF

    • This question is part of the following fields:

      • Endocrine Physiology
      • Physiology
      25.2
      Seconds
  • Question 13 - Which of the following is an example of a non-parametric test: ...

    Correct

    • Which of the following is an example of a non-parametric test:

      Your Answer: All of the above

      Explanation:

      All of the above answers are non-parametric tests.

    • This question is part of the following fields:

      • Evidence Based Medicine
      • Statistics
      3.5
      Seconds
  • Question 14 - Among the following infectious diseases, which is typically considered to have an incubation...

    Incorrect

    • Among the following infectious diseases, which is typically considered to have an incubation period of less than 3 weeks?

      Your Answer: Infectious mononucleosis

      Correct Answer: Diphtheria

      Explanation:

      C. diphtheriae, which is the causative agent of diphtheria, is carried in the upper respiratory tract and spread by droplet infection or hand-to-mouth contact. The incubation period averages 2 to 5 days.Infectious mononucleosis is caused by Epstein-Barr virus (EBV). The incubation period for EBV varies from 2 weeks to 2 months.The incubation for Hepatitis A virus is approximately 1 month.The incubation period for Hepatitis C ranges from 2 weeks to 6 months.The period from infection to development of anti-HIV antibodies is usually less than 1 month but may be up to 3 months.

    • This question is part of the following fields:

      • Microbiology
      • Specific Pathogen Groups
      9.7
      Seconds
  • Question 15 - Which of the following best describes the order in which blood passes through...

    Correct

    • Which of the following best describes the order in which blood passes through the nephron? 

      Your Answer: Afferent arteriole→Glomerular capillary→Efferent arteriole→Peritubular capillary→Vasa recta

      Explanation:

      The nephron’s blood flow is as follows:Afferent arteriole – Glomerular capillary – Efferent arteriole – Peritubular capillary – Vasa recta – Afferent arteriole – Glomerular capillary – Efferent arteriole – Peritubular capillary – Vasa rectaThe kidney is the only vascular network in the body with two capillary beds. With arterioles supplying and draining the glomerular capillaries, higher hydrostatic pressures at the glomerulus are maintained, allowing for better filtration. A second capillary network at the tubules enables for secretion and absorption in the tubules, as well as concentrating urine.

    • This question is part of the following fields:

      • Physiology
      • Renal Physiology
      13.7
      Seconds
  • Question 16 - The functional residual capacity (FRC) will be increased in which of the following:...

    Correct

    • The functional residual capacity (FRC) will be increased in which of the following:

      Your Answer: Emphysema

      Explanation:

      Factors increasing FRC:EmphysemaAir trapping in asthmaAgeing (due to loss of elastic properties)Increasing height of patient

    • This question is part of the following fields:

      • Physiology
      • Respiratory
      3
      Seconds
  • Question 17 - Regarding Clostridium perfringens, which of the following statements is CORRECT: ...

    Correct

    • Regarding Clostridium perfringens, which of the following statements is CORRECT:

      Your Answer: It can cause exotoxin-mediated food poisoning.

      Explanation:

      Clostridium perfringens is an obligate anaerobe and has exotoxin mediated effects. It is the most common cause of gas gangrene. C. perfringens is also implicated in food poisoning, cellulitis, enteritis necrotican (life-threatening infection involving ischaemic necrosis of the jejunum), and rarely, CNS infections such as meningitis and encephalitis.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      6.8
      Seconds
  • Question 18 - Regarding disseminated intravascular coagulation (DIC), which of the following statements is INCORRECT: ...

    Incorrect

    • Regarding disseminated intravascular coagulation (DIC), which of the following statements is INCORRECT:

      Your Answer: DIC more commonly presents with features of bleeding rather than thrombosis.

      Correct Answer: Thrombocytosis results in widespread platelet aggregation.

      Explanation:

      DIC is characterised by a widespread inappropriate intravascular deposition of fibrin with consumption of coagulation factors and platelets. This may occur as a consequence of many disorders that release procoagulant material into the circulation or cause widespread endothelial damage or platelet aggregation. Increased activity of thrombin in the circulation overwhelms its normal rate of removal by natural anticoagulants. In addition to causing increased deposition of fibrin in the microcirculation and widespread platelet aggregation to the vessels, intravascular thrombin formation interferes with fibrin polymerisation. Intense fibrinolysis is stimulated by thrombi on vascular walls and the release of fibrin degradation products again interferes with fibrin polymerisation. The combined action of thrombin and plasmin causes depletion of fibrinogen and all coagulation factors, compounded by thrombocytopaenia caused by platelet consumption.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      22.5
      Seconds
  • Question 19 - A 35-year-old man is feeling unwell following his return from a business trip....

    Correct

    • A 35-year-old man is feeling unwell following his return from a business trip. He is diagnosed with a vector transmitted disease.Which of these organisms is commonly spread by vector-borne transmission?

      Your Answer: Borrelia burgdorferi

      Explanation:

      Borrelia burgdorferiis, primarily spread by ticks and lice, is a zoonotic, vector-borne organism that causes Lyme disease.Neisseria meningitidis and Bordetella pertussis are droplet borne infections (airborne particle > 5 µm)Vibrio cholerae and Ascaris lumbricoides are spread by the faeco-oral route

    • This question is part of the following fields:

      • Microbiology
      • Principles Of Microbiology
      11.8
      Seconds
  • Question 20 - A 58-year-old man with a traumatic brain injury is brought into the ER....

    Incorrect

    • A 58-year-old man with a traumatic brain injury is brought into the ER. A medical student asks you about the processes that occur in the brain following a traumatic injury.One of these best describes the central nervous systems response to injury.

      Your Answer: Microglia undergo reactive gliosis to leave behind firm translucent tissue

      Correct Answer: Degeneration of the axon occurs proximally before it occurs distally

      Explanation:

      Following neuronal injury, as seen in traumatic brain injury, the axon undergoes anterograde degeneration. Degradation starts from the cell body (proximally) and progresses distally. The axon becomes fragmented and degenerates. The brain shows no reactive changes to injury is incorrect. Following major injury such as stroke, the brain undergoes a process of liquefactive degeneration, which leaves cystic spaces within the brain.Axonal regeneration does not occur to any significant extent within the central nervous system unlike what is seen in the peripheral nervous system. Astrocytes undergo reactive gliosis, leaving behind a firm translucent tissue around sites of damage.

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      16.4
      Seconds
  • Question 21 - Pressure across the wall of a flexible tube (the transmural pressure) increases wall...

    Correct

    • Pressure across the wall of a flexible tube (the transmural pressure) increases wall tension and extends it.Which law best describes transmural pressure?

      Your Answer: Laplace’s law

      Explanation:

      The transmural pressure (pressure across the wall of a flexible tube) can be described by Laplace’s law which states that:Transmural pressure = (Tw) / rWhere:T = Wall tensionw = Wall thicknessr = The radiusA small bubble with the same wall tension as a larger bubble will contain higher pressure and will collapse into the larger bubble if the two meet and join.Fick’s law describes the rate of diffusion in a solutionPoiseuille’s law is used to calculate volume of flow rate in laminar flowDarcy’s law describes the flow of a fluid through a porous medium.Starling’s law describes cardiac haemodynamics as it relates to myocyte contractility and stretch.

    • This question is part of the following fields:

      • Basic Cellular Physiology
      • Physiology
      12.2
      Seconds
  • Question 22 - A patient who was put on low molecular weight heparin for suspected DVT...

    Correct

    • A patient who was put on low molecular weight heparin for suspected DVT and was scheduled for an ultrasound after the weekend, arrives at the emergency department with significant hematemesis. Which of the following medications can be used as a heparin reversal agent:

      Your Answer: Protamine sulfate

      Explanation:

      The management of bleeding in a patient receiving heparin depends upon the location and severity of bleeding, the underlying thromboembolic risk, and the current aPTT (for heparin) or anti-factor Xa activity (for LMW heparin). As an example, a patient with minor skin bleeding in the setting of a mechanical heart valve (high thromboembolic risk) and a therapeutic aPTT may continue heparin therapy, whereas a patient with major intracerebral bleeding in the setting of venous thromboembolism several months prior who is receiving heparin bridging perioperatively may require immediate heparin discontinuation and reversal with protamine sulphate. If haemorrhage occurs it is usually sufficient to withdraw unfractionated or low molecular weight heparin, but if rapid reversal of the effects of the heparin is required, protamine sulphate is a specific antidote (but only partially reverses the effects of low molecular weight heparins). Clinician judgment and early involvement of the appropriate consulting specialists is advised.

    • This question is part of the following fields:

      • Cardiovascular
      • Pharmacology
      6.2
      Seconds
  • Question 23 - A 77 year old lady presents to ED with her left leg shortened...

    Correct

    • A 77 year old lady presents to ED with her left leg shortened and externally rotated following slipping and falling on a wet bathroom floor. There is an intracapsular fracture of the neck of femur seen on imaging studies. She is at risk of avascular necrosis of the head of femur. This is caused by lack of blood supply from which of these arteries?

      Your Answer: Medial circumflex artery

      Explanation:

      The primary blood supply to the head of the femur is from branches of the medial femoral circumflex artery. The superior and inferior gluteal arteries supply the hip joint but not the head of femur.The lateral circumflex artery anastomoses with the medial femoral circumflex artery and assists in supplying the head of femur. The obturator artery is an important source of blood supply in children up to about 8 years. It gives rise to the artery of the head of femur which runs in the ligamentum teres and is insufficient to supply the head of femur in adults.

    • This question is part of the following fields:

      • Anatomy
      • Lower Limb
      6.3
      Seconds
  • Question 24 - Regarding Clostridium species, which of the following statements is INCORRECT: ...

    Incorrect

    • Regarding Clostridium species, which of the following statements is INCORRECT:

      Your Answer: They are rod-shaped.

      Correct Answer: They are facultative anaerobes.

      Explanation:

      Clostridium spp. are obligatory anaerobic spore-forming Gram-positive bacilli. Toxin production is the main pathogenicity mechanism.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      7.8
      Seconds
  • Question 25 - How does an action potential in the motor end plate rapidly spread to...

    Correct

    • How does an action potential in the motor end plate rapidly spread to the central portions of the muscle cells?

      Your Answer: Transverse tubules

      Explanation:

      When the concentration of intracellular Ca2+rises, muscle contraction occurs. The pathway of an action potential is down tube-shaped invaginations of the sarcolemma called T-tubules (transverse tubules). These penetrate throughout the muscle fibre and lie adjacent to the terminal cisternae of the sarcoplasmic reticulum. The voltage changes in the T-tubules result in the opening of sarcoplasmic reticulum Ca2+channels and there is there is release of stored Ca2+into the sarcoplasm. Thus muscle contraction occurs via excitation-contraction coupling (ECC) mechanism.

    • This question is part of the following fields:

      • Basic Cellular
      • Physiology
      14
      Seconds
  • Question 26 - A 24-year-old female visits her family physician to complain of painless lumps in...

    Correct

    • A 24-year-old female visits her family physician to complain of painless lumps in her neck. Her physician notes several enlarged, rubbery, non-tender cervical lymph nodes on examination. He immediately refers the patient for a lymph node biopsy, the results of which show the presence of Reed-Sternberg cells. What is the diagnosis in this case based on the above scenario?

      Your Answer: Hodgkin’s lymphoma

      Explanation:

      The presence of Reed-Sternberg cells is pathognomonic for Hodgkin’s Lymphoma, which is a disease-causing neoplastic transformation of lymphocytes. There is a bimodal age distribution with peaks in the 20s and 60s. Patients typically present with enlarged, rubbery, non-tender lymph nodes. Symptoms such as fever, night sweats and weight loss may be present. Pain after alcohol consumption is a pathognomonic sign of Hodgkin’s lymphoma, it is, however, not a ‘B’ symptom. It is rare though, only occurring in 2-3% of patients with Hodgkin’s lymphoma.The Ann Arbour clinical staging is as follows:Stage I: one involved lymph node groupStage II two involved lymph node groups on one side of the diaphragmStage III: lymph node groups involved on both sides of the diaphragmStage IV: Involvement of extra-nodal tissues, such as the liver or bone marrowDiagnosis is made by lymph node biopsy, which should be taken from a sufficiently large specimen or excisional biopsy, as opposed to a fine needle biopsy. Multiple myeloma most commonly presents with bone pain, especially in the back and ribs. In non-Hodgkin’s lymphoma, Reed-Sternberg cells are not present. Acute lymphoblastic leukaemia will present with features of anaemia, thrombocytopenia and leukopenia. The most common symptoms of chronic lymphocytic leukaemia are fatigue, night sweats and low-grade fever.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      9.2
      Seconds
  • Question 27 - All of the statements regarding vascular tone are correct except: ...

    Incorrect

    • All of the statements regarding vascular tone are correct except:

      Your Answer: Most types of vascular smooth muscle do not generate action potentials, but instead depolarisation is graded, allowing graded entry of Ca2+.

      Correct Answer: Most endogenous vasodilators act by decreasing levels of cAMP or cGMP.

      Explanation:

      Most vasoconstrictors bind to G-protein coupled receptors. These mediate elevation in intracellular [Ca2+] which leads to vascular smooth muscle contraction. Important vasoconstrictors include noradrenaline, endothelin-1 and angiotensin II. Increased intracellular Ca2+ is as a result of the release of Ca2+from the sarcoplasmic reticulum and depolarisation and entry of Ca2+via L-type voltage-gated Ca2+channels. Most types of vascular smooth muscle do not generate action potentials – instead, the depolarisation is graded, which allows graded entry of Ca2+.sequestration by the sarcoplasmic reticulum Ca2+ATPase, removal from the cell by a plasma membrane Ca2+ATPase and Na+/Ca2+exchange decreases intracellular Ca2+, resulting in vasodilation. Relaxation is a result of most endogenous vasodilators when there is an increase in cyclic guanosine monophosphate (cGMP) like nitric oxide) or cyclic adenosine monophosphate (cAMP) like prostacyclin and beta-adrenergic receptor agonists. These activate protein kinases causing substrate level phosphorylation. Clinically effective vasodilators are L-type Ca2+channel blocker drugs.

    • This question is part of the following fields:

      • Cardiovascular
      • Physiology
      19.6
      Seconds
  • Question 28 - A young pregnant woman is in the late stages of her pregnancy. She...

    Correct

    • A young pregnant woman is in the late stages of her pregnancy. She is administered a drug that results in her newborn being born with respiratory depression. The baby also suffers from neonatal withdrawal syndrome.Out of the following, which drug is most likely responsible for the baby's condition?

      Your Answer: Diazepam

      Explanation:

      Benzodiazepines are used as a first-line treatment in breaking seizures and in status epilepticus as they are rapid-acting. Use of benzodiazepines in the late third-trimester or exposure during labour is associated with great risks to the foetus/neonate. Babies can exhibit either floppy infant syndrome, or marked neonatal withdrawal symptoms. Symptoms vary from mild sedation, hypotonia, and reluctance to suck, to apnoeic spells, cyanosis, and impaired metabolic responses to cold stress. These symptoms have been reported to persist for periods from hours to months after birth. They also cross into breast milk and should be used with caution in breastfeeding mothers

    • This question is part of the following fields:

      • CNS Pharmacology
      • Pharmacology
      8
      Seconds
  • Question 29 - A 34-year-old man presents with loss of vision in his left eye due...

    Correct

    • A 34-year-old man presents with loss of vision in his left eye due to an episode of optic neuritis. Upon history taking, it was noted that he has a history of multiple sclerosis. Which of the following anatomical points in the visual pathway has the lesion occurred?

      Your Answer: Optic nerve

      Explanation:

      A lesion in the optic nerve causes ipsilateral monocular visual loss.Optic neuritis is an inflammatory demyelination of the optic nerve that is highly associated with multiple sclerosis. The two most common symptoms of optic neuritis are vision loss and eye pain.

    • This question is part of the following fields:

      • Anatomy
      • Central Nervous System
      5.9
      Seconds
  • Question 30 - Which of the following accurately describes the extensor pollicis brevis muscle? ...

    Incorrect

    • Which of the following accurately describes the extensor pollicis brevis muscle?

      Your Answer: It extends the distal phalanx of the thumb at the metacarpophalangeal joint

      Correct Answer: It lies on the medial side of abductor pollicis longus

      Explanation:

      Extensor pollicis brevis is a short and slender muscle located in the posterior compartment of the forearm, extending from the posterior surface of radius to the proximal phalanx of thumb. It is one of the deep extensors of the forearm, together with supinator, abductor pollicis longus, extensor pollicis longus and extensor indicis muscles.Extensor pollicis brevis is a deep extensor of the thumb that lies deep to extensor digitorum muscle. It sits directly medial to abductor pollicis longus and posterolateral to extensor pollicis longus muscle. Just above the wrist, extensor pollicis brevis obliquely crosses the tendons of extensor carpi radialis brevis and extensor carpi radialis longus muscles.Extensor pollicis brevis is innervated by posterior interosseous nerve which is a continuation of a deep branch of radial nerve (root value C7 and C8).Extensor pollicis brevis receives its blood supply by posterior interosseous artery and perforating branches from the anterior interosseous artery, which are the branches of common interosseous artery. The common interosseous artery arises immediately below the tuberosity of radius from the ulnar artery.Together with extensor pollicis longus, extensor pollicis brevis is in charge of extension of the thumb in the first metacarpophalangeal joint. It also extends the thumb in the carpometacarpal joint of the thumb. This movement is important in the anatomy of the grip, as it enables letting go of an object. As it crosses the wrist, extensor pollicis brevis also participates in the extension and abduction of this joint.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      18.6
      Seconds
  • Question 31 - A 30-year-old man present to the ED with abdominal pain, nausea and vomiting....

    Correct

    • A 30-year-old man present to the ED with abdominal pain, nausea and vomiting. It has been present for the past two days.Which of the following statements regarding diarrhoea and vomiting is true?

      Your Answer: E.Coli can cause diarrhoea and renal failure

      Explanation:

      Escherichia coli strain 0157 causes enterohaemorrhagic diarrhoea and can lead to renal failure, haemolytic anaemia and thrombocytopenia.Norwalk virus is an RNA virus.Although transmission of rotavirus is primarily through the faeco-oral route, airborne spread has been seen in some cases.Cryptosporidium are protozoa with acid fast walls and are resistant to both chlorine treatment and conventional filtering methods. There is no therapy effective in treating cryptosporidium diarrhoea as the protozoa is not susceptible to antibiotics.

    • This question is part of the following fields:

      • Microbiology
      • Specific Pathogen Groups
      10.1
      Seconds
  • Question 32 - Gastrin primarily acts to perform which of the following functions: ...

    Correct

    • Gastrin primarily acts to perform which of the following functions:

      Your Answer: Stimulate gastric acid secretion

      Explanation:

      Gastrin primarily  acts to stimulate acid secretion from parietal cells (both directly and indirectly by stimulating release of histamine from ECL cells).

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      3.2
      Seconds
  • Question 33 - A 70-year-old patient is diagnosed with Cushing's disease. She has a history of...

    Correct

    • A 70-year-old patient is diagnosed with Cushing's disease. She has a history of weight gain, hypertension, and easy bruising.In this patient, which of the following is the MOST LIKELY UNDERLYING CAUSE?

      Your Answer: Pituitary adenoma

      Explanation:

      Cushing’s syndrome is a collection of symptoms and signs caused by prolonged exposure to elevated levels of either endogenous or exogenous glucocorticoids.The most common cause of Cushing’s syndrome is the iatrogenic administration of corticosteroids. The second most common cause of Cushing’s syndrome is Cushing’s disease.Cushing’s disease should be distinguished from Cushing’s syndrome and refers to one specific cause of the syndrome, an adenoma of the pituitary gland that secretes large amounts of ACTH and, in turn, elevates cortisol levels. This patient has a diagnosis of Cushing’s disease, and this is, therefore, the underlying cause in this case.The endogenous causes of Cushing’s syndrome include:Pituitary adenoma (Cushing’s disease)Ectopic corticotropin syndrome, e.g. small cell carcinoma of the lungAdrenal hyperplasiaAdrenal adenomaAdrenal carcinoma

    • This question is part of the following fields:

      • Endocrine Physiology
      • Physiology
      8.4
      Seconds
  • Question 34 - Which of the following microbes produces exotoxin: ...

    Correct

    • Which of the following microbes produces exotoxin:

      Your Answer: Clostridium tetani

      Explanation:

      Clostridium tetani (causing tetanus) produces the exotoxin tetanospasmin which causes its neurotoxic effects.

    • This question is part of the following fields:

      • Microbiology
      • Principles
      4.9
      Seconds
  • Question 35 - Regarding the hard palate, which of the following statements is CORRECT: ...

    Correct

    • Regarding the hard palate, which of the following statements is CORRECT:

      Your Answer: Lymphatic vessels from the palate usually drain into deep cervical lymph nodes.

      Explanation:

      Lymphatic vessels from the pharynx and palate drain into the deep cervical lymph nodes.

    • This question is part of the following fields:

      • Anatomy
      • Head And Neck
      11.7
      Seconds
  • Question 36 - Which of the following is NOT a notifiable disease: ...

    Correct

    • Which of the following is NOT a notifiable disease:

      Your Answer: Chickenpox

      Explanation:

      Chickenpox is not a notifiable disease.

    • This question is part of the following fields:

      • Infections
      • Pharmacology
      4.5
      Seconds
  • Question 37 - A 75-year-old man with rheumatoid arthritis had gained weight, developed resistant hypertension, muscle...

    Correct

    • A 75-year-old man with rheumatoid arthritis had gained weight, developed resistant hypertension, muscle weakness, and ankle oedema. This patient is most likely suffering from what condition?

      Your Answer: Cushing's syndrome

      Explanation:

      Overuse of cortisol medication, as seen in the treatment of patients with chronic asthma or rheumatoid arthritis, can cause Cushing’s syndrome. Weight gain, thin arms and legs, a round face, increased fat around the base of the neck, a fatty hump between the shoulders, easy bruising, wide purple stretch marks primarily on the abdomen, breasts, hips, and under the arms, weak muscles, hirsutism, hypertension, erectile dysfunction, osteoporosis, frontal alopecia, acne, depression, poor wound healing, and polycythaemia are all clinical features of Cushing’s syndrome.

    • This question is part of the following fields:

      • Endocrine
      • Physiology
      5.8
      Seconds
  • Question 38 - A 43-year old male is taken to the Emergency Room for a lacerated...

    Correct

    • A 43-year old male is taken to the Emergency Room for a lacerated wound on the abdomen, situated above the umbilicus. A short segment of the small bowel has herniated through the wound.Which of these anatomic structures is the deepest structure injured in the case above?

      Your Answer: Transversalis fascia

      Explanation:

      The following structures are the layers of the anterior abdominal wall from the most superficial to the deepest layer:SkinFatty layer of the superficial fascia (Camper’s fascia)Membranous layer of the superficial fascia (Scarpa’s fascia)Aponeurosis of the external and internal oblique musclesRectus abdominis muscleAponeurosis of the internal oblique and transversus abdominisFascia transversalisExtraperitoneal fatParietal peritoneum

    • This question is part of the following fields:

      • Abdomen And Pelvis
      • Anatomy
      10.2
      Seconds
  • Question 39 - Regarding the UK routine childhood immunisation schedule which of the following vaccines is...

    Correct

    • Regarding the UK routine childhood immunisation schedule which of the following vaccines is NOT given at 2 months:

      Your Answer: Meningococcal group C

      Explanation:

      At 2 months the following vaccines are given: Diphtheria, tetanus, pertussis, polio, Haemophilus influenzae type b (Hib) and hepatitis BRotavirus gastroenteritisMeningococcal group B

    • This question is part of the following fields:

      • Immunoglobulins And Vaccines
      • Pharmacology
      9
      Seconds
  • Question 40 - A 29-year-old woman with anaphylactic reaction to peanuts, had to use her EpiPen...

    Correct

    • A 29-year-old woman with anaphylactic reaction to peanuts, had to use her EpiPen on the way to hospital. What percentage of patients with anaphylactic reaction suffer a biphasic response?.

      Your Answer: 20%

      Explanation:

      About 20% of patients that suffer an anaphylactic reaction suffer a biphasic response 4-6 hours after the initial response (sometimes up to 72 hours after).

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      2.8
      Seconds
  • Question 41 - In adults, there are normally how many teeth: ...

    Correct

    • In adults, there are normally how many teeth:

      Your Answer: 32

      Explanation:

      In adults, there are 32 teeth, 16 in the upper jaw and 16 in the lower jaw. On each side in both upper and lower arches, there are two incisors, one canine, two premolars and three molar teeth.

    • This question is part of the following fields:

      • Anatomy
      • Head And Neck
      2.5
      Seconds
  • Question 42 - Where: Capillary hydrostatic pressure is (P c) Hydrostatic pressure in the interstices is (P I...

    Correct

    • Where: Capillary hydrostatic pressure is (P c) Hydrostatic pressure in the interstices is (P I )Plasma oncotic pressure is (Ï€ p) Interstitial oncotic pressure is (Ï€ i)Which of the following formulas best represents fluid flow at the capillary bed?

      Your Answer: Volume / min = (P c - P i ) - (π p - π i )

      Explanation:

      Starling’s equation for fluid filtration describes fluid flow at the capillary bed.Filtration forces (capillary hydrostatic pressure and interstitial oncotic pressure) stimulate fluid movement out of the capillary, while resorption forces promote fluid movement into the capillary (interstitial hydrostatic pressure and plasma oncotic pressure). Although the forces fluctuate along the length of the capillary bed, overall filtration is achieved.At the capillary bed, there is fluid movement.The reflection coefficient (σ), the surface area accessible (S), and the hydraulic conductance of the wall (Lp) are frequently used to account for the endothelium’s semi-permeability, yielding:Volume / min = LpS [(Pc- Pi) –  σ(Ï€p– Ï€i)]Volume /min = (Pc-Pi) – (Ï€p–πi) describes the fluid circulation at the capillaries.Where:Pc= capillary hydrostatic pressurePi= interstitial hydrostatic pressureÏ€p= plasma oncotic pressureÏ€i= interstitial oncotic pressure

    • This question is part of the following fields:

      • Cardiovascular Physiology
      • Physiology
      23.7
      Seconds
  • Question 43 - A 16-year old boy is brought to the emergency room after suffering a...

    Correct

    • A 16-year old boy is brought to the emergency room after suffering a traffic accident. Upon examination, there is noted ipsilateral loss of proprioception and vibration, ipsilateral motor loss, and contralateral loss of pain and temperature sensation. A spinal cord injury is given as a diagnosis.Which of the following is the most probable cause of this manifestation?

      Your Answer: Brown-Séquard syndrome

      Explanation:

      Brown-Sequard Hemicord Syndrome consists of ipsilateral weakness (corticospinal tract) and loss of joint position and vibratory sense (posterior column), with contralateral loss of pain and temperature sense (spinothalamic tract) one or two levels below the lesion. Segmental signs, such as radicular pain, muscle atrophy, or loss of a deep tendon reflex, are unilateral. Partial forms are more common than the fully developed syndrome.

    • This question is part of the following fields:

      • Anatomy
      • Central Nervous System
      34.2
      Seconds
  • Question 44 - All of the following statements are considered true regarding L'Abbe plots, except: ...

    Incorrect

    • All of the following statements are considered true regarding L'Abbe plots, except:

      Your Answer: They are a type of scatter-plot

      Correct Answer: Treatment group results are plotted on the horizontal axis

      Explanation:

      A L’Abbé plot is a scatter plot with the risk in the control group on the x-axis and the risk in the experimental group on the y-axis. It can be used to evaluate heterogeneity in meta-analysis. Furthermore, this plot can aid to choose a summary measure (odds ratio, risk ratio, risk difference) that will result in more consistent results.

    • This question is part of the following fields:

      • Evidence Based Medicine
      4.3
      Seconds
  • Question 45 - At which vertebral level does the spinal cord normally end in adults? ...

    Correct

    • At which vertebral level does the spinal cord normally end in adults?

      Your Answer: L1/L2

      Explanation:

      The spinal cord starts at the foramen magnum, where it is continuous with the medulla oblongata, which is the most caudal portion of the brainstem.It then extends inferiorly through the vertebral canal. In adults, it usually ends at the level of the first or second lumbar vertebra.

    • This question is part of the following fields:

      • Anatomy
      • Head And Neck
      1.7
      Seconds
  • Question 46 - Lidocaine's mechanism of action as a local aesthetic is as follows: ...

    Incorrect

    • Lidocaine's mechanism of action as a local aesthetic is as follows:

      Your Answer: Blocks opening of ligand-gated Na+ channels

      Correct Answer: Blocks influx of Na+ through voltage-gated Na+ channels

      Explanation:

      Local anaesthetics prevent generation/conduction of nerve impulses by reducing sodium permeability and increasing action potential threshold; inhibits depolarization, which results in blockade of conduction

    • This question is part of the following fields:

      • Anaesthesia
      • Pharmacology
      4.8
      Seconds
  • Question 47 - A 70-year-old patient diagnosed with Cushing's syndrome and has a history of weight...

    Correct

    • A 70-year-old patient diagnosed with Cushing's syndrome and has a history of weight gain, hypertension, and easy bruising.Which of these assertions about Cushing's syndrome is correct?

      Your Answer: Diagnosis can be confirmed by a dexamethasone suppression test

      Explanation:

      Cushing’s syndrome is a group of symptoms and signs brought on by long-term exposure to high amounts of endogenous or exogenous glucocorticoids.Iatrogenic corticosteroid injection is the most prevalent cause of Cushing’s syndrome. Cushing’s illness is the second most prevalent cause of Cushing’s syndrome. Cushing’s disease is distinct from Cushing’s syndrome in that it refers to a single cause of the illness, a pituitary adenoma that secretes high quantities of ACTH, which raises cortisol levels.Because cortisol enhances the vasoconstrictive impact of endogenous adrenaline, patients with Cushing’s syndrome are usually hypertensive.Hyperglycaemia (due to insulin resistance) rather than hypoglycaemia is a common symptom.Cortisol levels fluctuate throughout the day, with the greatest levels occurring around 0900 hours and the lowest occurring at 2400 hrs during sleep. The diurnal swing of cortisol levels is lost in Cushing’s syndrome, and levels are greater throughout the 24-hour period. In the morning, levels may be normal, but they may be high at night-time, when they are generally repressed.A dexamethasone suppression test or a 24-hour urine free cortisol collection can both be used to establish the existence of Cushing’s syndrome.

    • This question is part of the following fields:

      • Endocrine Physiology
      • Physiology
      11.3
      Seconds
  • Question 48 - Regarding propofol, which of the following statements is INCORRECT: ...

    Correct

    • Regarding propofol, which of the following statements is INCORRECT:

      Your Answer: A lower induction dose of propofol is required in children.

      Explanation:

      Elderly patients have a reduced volume of distribution and slower clearance of the drug. They are therefore more sensitive to the effects of propofol and the drug wears off more slowly. They need less of the drug, which should be injected slowly, monitoring its effect on the patient. The opposite is true in children, who need larger doses of propofol. This is particularly so in children under three years of age. Propofol is not recommended for induction of anaesthesia in children under one month of age or for maintenance of anaesthesia in children under three years old.

    • This question is part of the following fields:

      • Anaesthesia
      • Pharmacology
      5.2
      Seconds
  • Question 49 - A patient has an elevated potassium level of 6.7 mmol/L. All of the...

    Correct

    • A patient has an elevated potassium level of 6.7 mmol/L. All of the following conditions may cause elevated potassium levels, except for which one?

      Your Answer: Bartter’s syndrome

      Explanation:

      Bartter’s syndrome is an autosomal recessive renal tubular disorder characterized by hypokalaemia, hypochloraemia, metabolic alkalosis, and hyperreninemia with normal blood pressure. The underlying kidney abnormality results in excessive urinary losses of sodium, chloride, and potassium. Bartter’s syndrome does not cause an elevated potassium level, but instead causes a decrease in its concentration (hypokalaemia). The other choices are causes of hyperkalaemia or elevated potassium levels. Renal failure, Addison’s disease (adrenal insufficiency), congenital adrenal hyperplasia, renal tubular acidosis (type 4), rhabdomyolysis, burns and trauma, tumour syndrome, and acidosis are non-drug causes of hyperkalaemia. On the other hand, drugs that can cause hyperkalaemia include ACE inhibitors, angiotensin receptor blockers, NSAIDs, beta-blockers, digoxin, and suxamethonium.

    • This question is part of the following fields:

      • Physiology
      • Renal Physiology
      8.3
      Seconds
  • Question 50 - A 25-year-old guy who has had a knee-high plaster cast on his left...

    Correct

    • A 25-year-old guy who has had a knee-high plaster cast on his left leg for the past 5 weeks arrives at the emergency department complaining of numbness on the dorsum of his left foot and an inability to dorsiflex or evert his foot. You know that his symptoms are due to fibular nerve compression. Where is the fibular nerve located?

      Your Answer: Neck of fibula

      Explanation:

      Dorsiflexion and eversion of the foot are innervated by the deep fibular nerve and the superficial fibular nerve, respectively. The common fibular nerve runs obliquely downward along the lateral border of the popliteal fossa (medial to the biceps femoris) before branching at the neck of the fibula. Thus, it is prone to being affected during an impact injury or fracture to the bone or leg. Casts that are placed too high can also compress the fibular nerve.

    • This question is part of the following fields:

      • Anatomy
      • Lower Limb
      4.5
      Seconds
  • Question 51 - In the resus area of your Emergency Department, you are called to a...

    Correct

    • In the resus area of your Emergency Department, you are called to a VF cardiac arrest.During an adult VF arrest, which of the following points should be treated with adrenaline?

      Your Answer: After the 3 rd shock, once chest compressions have been resumed

      Explanation:

      In non-shockable (PEA/asystole) cardiac arrests, adrenaline should be given as soon as circulatory access is gained. The dose is 1 mg via IV or IO (10 mL of 1:10,000 or 1 mL of 1:1000).Once chest compressions have been resumed after the third shock in a shockable (Vf/pVT) cardiac arrest, adrenaline should be administered. The dosage is one milligram (10 mL of 1:10,000 or 1 mL of 1:1000)It should be given every 3-5 minutes after that (i.e. alternate loops) and without interrupting chest compressions.Systemic vasoconstriction is caused by the alpha-adrenergic effects of adrenaline, which raises coronary and cerebral perfusion pressures.Adrenaline’s beta-adrenergic effects are inotropic (increased myocardial contractility) and chronotropic (increased heart rate), and they can increase coronary and cerebral blood flow. However, concomitant increases in myocardial oxygen consumption and ectopic ventricular arrhythmias (especially in the absence of acidaemia), transient hypoxemia due to pulmonary arteriovenous shunting, impaired microcirculation, and increased post-cardiac arrest myocardial dysfunction may offset these benefits.Although there is no evidence of long-term benefit from its use in cardiac arrest, the improved short-term survival reported in some studies justifies its use.

    • This question is part of the following fields:

      • Cardiovascular Pharmacology
      • Pharmacology
      8.5
      Seconds
  • Question 52 - Following a decrease in extracellular volume, which of the following is a reaction...

    Correct

    • Following a decrease in extracellular volume, which of the following is a reaction to enhanced sympathetic innervation of the kidney:

      Your Answer: Release of renin

      Explanation:

      The RAS pathway begins with renin cleaving its substrate, angiotensinogen (AGT), to produce the inactive peptide, angiotensin I, which is then converted to angiotensin II by endothelial angiotensin-converting enzyme (ACE). ACE activation of angiotensin II occurs most extensively in the lung. Angiotensin II mediates vasoconstriction as well as aldosterone release from the adrenal gland, resulting in sodium retention and increased blood pressure.

    • This question is part of the following fields:

      • Physiology
      • Renal
      10.8
      Seconds
  • Question 53 - Regarding relationships between two variables, what does a negative correlation coefficient indicate: ...

    Incorrect

    • Regarding relationships between two variables, what does a negative correlation coefficient indicate:

      Your Answer: As one variable decreases, the other variable decreases

      Correct Answer: The two variables are inversely related

      Explanation:

      A negative correlation coefficient means that the two variables are inversely related e.g. socio-economic class and mortality.

    • This question is part of the following fields:

      • Evidence Based Medicine
      • Statistics
      6.5
      Seconds
  • Question 54 - Regarding flucloxacillin, which of the following statements is CORRECT: ...

    Correct

    • Regarding flucloxacillin, which of the following statements is CORRECT:

      Your Answer: It is resistant to bacterial beta-lactamases.

      Explanation:

      Flucloxacillin is unique in that it is beta-lactamase stable and it can be used in infections caused by beta-lactamase producing staphylococci e.g. S. aureus. It is acid-stable and can therefore be given by mouth as well as by injection. It is used first line for treatment of widespread impetigo infection, cellulitis, mastitis, osteomyelitis, septic arthritis, severe erysipelas, severe/spreading otitis externa and infective endocarditis caused by staphylococci. The most common adverse effects of flucloxacillin include nausea, vomiting, skin rash, and diarrhoea. Cholestatic jaundice and hepatitis may occur very rarely, up to two months after treatment with flucloxacillin has been stopped. Administration for more than 2 weeks and increasing age are risk factors. First line treatment of animal and human bites is co-amoxiclav.

    • This question is part of the following fields:

      • Infections
      • Pharmacology
      3.7
      Seconds
  • Question 55 - A 61-year-old woman returns to get the results of recent blood tests she...

    Correct

    • A 61-year-old woman returns to get the results of recent blood tests she had done for non-specific malaise, lethargy, and weight loss. The only abnormality discovered during the blood tests was a 580 x 10 9 /l increase in platelets. Her platelets were also elevated on a blood test taken 6 months earlier, according to her previous results. You're aware of the recent emergence of elevated platelet levels as a cancer risk marker and decide to look into it.Which of the following cancers is most likely to cause isolated thrombocytosis?

      Your Answer: Colorectal cancer

      Explanation:

      Raised platelet levels have emerged as a cancer risk marker, according to a large population-based study published in 2017(link is external). According to the study, 12 percent of men and 6% of women with thrombocytosis were diagnosed with cancer within a year. These figures increased to 18% in men and 10% in women if a second platelet count was taken within 6 months of the first and showed an increased or stable elevated platelet count.The researchers discovered that thrombocytosis linked to cancer is most common in colorectal and lung cancers, and it is linked to a worse prognosis. Furthermore, one-third of the cancer patients in the study had no other symptoms that would have prompted an immediate cancer referral.The exact mechanism by which these cancers cause thrombocytosis is unknown, but one theory proposes the existence of pathogenic feedback loops between malignant cells and platelets, with a reciprocal interaction between tumour growth and metastasis, as well as thrombocytosis and platelet activation. Another hypothesis is that thrombocytosis occurs independently of cancer but aids in its spread and progression.The findings show that routinely testing for thrombocytosis could cut the time it takes to diagnose colorectal and lung cancer by at least two months. In the UK, this could result in around 5500 earlier cancer diagnoses per year.Because the positive predictive value of thrombocytosis in middle age for cancer (10%) is higher than the positive predictive value for a woman in her 50s presenting with a new breast lump (8.5%), this is clearly an important research paper that should be used to adjust future clinical practise. The current NICE guidelines predate these new research findings, so we’ll have to wait and see how they affect cancer referral guidelines in the UK.Because there are so many possible cancers associated with thrombocytosis, the treating clinician should take a thorough history and perform a thorough clinical examination if a patient is diagnosed with it. Further investigation and the most appropriate referral route should be aided by this information.It’s worth noting that the patients in the study had their blood tests done for a medical reason rather than as a random screening test.If there are no other symptoms to guide investigation and referral (one-third of the patients in the study had no other symptoms), keep in mind that the two most common cancers encountered were colorectal and lung cancer, so a chest X-ray and a faecal immunochemical test (FIT) for faecal blood may be reasonable initial investigations.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      12.7
      Seconds
  • Question 56 - A 52-year-old female visits the Emergency Department complaining of an acute worsening of...

    Correct

    • A 52-year-old female visits the Emergency Department complaining of an acute worsening of her asthma symptoms. A detailed history reveals that she took one of her brother's heart pills without a prescription as she was experiencing palpitations and thought it would cure her. Her shortness of breath was suddenly exacerbated after ingesting this medicine. Which one of the following medications has this woman most likely consumed?

      Your Answer: Propranolol

      Explanation:

      Propranolol, like other non-selective beta-blockers, is contraindicated in patients with asthma. These drugs can cause acute bronchospasm, therefore worsening symptoms, especially in high doses. However, there has been some recent evidence that long-term use of selective beta-blockers in mild or moderate asthma patients can be safe.

    • This question is part of the following fields:

      • Cardiovascular Pharmacology
      • Pharmacology
      17.8
      Seconds
  • Question 57 - A 78-year-old woman visits the emergency room with dizziness and nausea. She claims...

    Correct

    • A 78-year-old woman visits the emergency room with dizziness and nausea. She claims that her doctor gave her cinnarizine two days prior, but that it didn't seem to help.Cinnarizine's mechanism of action is which of the following?

      Your Answer: Antihistamine action

      Explanation:

      Cinnarizine is a piperazine derivative with an antihistamine effect that makes it anti-emetic. Motion sickness and vestibular disorders, such as Méniéres disease, are the most common conditions for which it is prescribed.

    • This question is part of the following fields:

      • CNS Pharmacology
      • Pharmacology
      8.2
      Seconds
  • Question 58 - A 17-year-old male presenting in the department has a history of C3 deficiency.C3...

    Correct

    • A 17-year-old male presenting in the department has a history of C3 deficiency.C3 deficiency is associated with all of the following EXCEPT?

      Your Answer: Hereditary angioedema

      Explanation:

      C1-inhibitor deficiency is the cause of hereditary angioedema not C3 deficiency,All the other statements are correct

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      4.3
      Seconds
  • Question 59 - A 64-year-old woman had a humerus midshaft fracture due to tripping on a...

    Correct

    • A 64-year-old woman had a humerus midshaft fracture due to tripping on a curb and falling on her left arm. She might also have damaged which of the following structures?

      Your Answer: Radial nerve and deep brachial artery

      Explanation:

      The radial nerve and brachial artery are most likely to be damaged in humerus fractures. They are tethered together to the bone and cannot withstand the forces applied to it as a result of the displacement.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      5.5
      Seconds
  • Question 60 - A 26-year-old male presents to your clinic with the complaint of recurrent fevers...

    Incorrect

    • A 26-year-old male presents to your clinic with the complaint of recurrent fevers over the past three months. On documentation of the fever, it is noted that the fever increases and decreases in a cyclical pattern over a 1-2 week period. After the appropriate investigations, a diagnosis of Pel-Ebstein fever is made. Which ONE of the following conditions is most likely to cause this patient's fever?

      Your Answer: Malaria

      Correct Answer: Hodgkin lymphoma

      Explanation:

      The release of cytokines from Reed-Sternberg cells can cause fever in patients with Hodgkin lymphoma, which increases and decreases in a cyclical pattern of 1 to 2 weeks. This is called Pel-Ebstein or Ebstein-Cardarelli fever, specifically seen in Hodgkin lymphoma. The fever is always high grade and can reach 40 degrees or higher.Cyclical fever in other conditions is common but is not termed as Pel-Ebstein fever. This term is reserved only with Hodgkin lymphoma.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      8.1
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

Abdomen And Pelvis (2/2) 100%
Anatomy (11/12) 92%
Head And Neck (4/4) 100%
Gastrointestinal (2/2) 100%
Physiology (13/14) 93%
Central Nervous System (3/3) 100%
Pharmacology (12/14) 86%
Microbiology (6/8) 75%
Pathogens (3/4) 75%
Anaesthesia (2/3) 67%
Haematology (3/6) 50%
Pathology (5/9) 56%
Cardiovascular Pharmacology (3/3) 100%
Fluids And Electrolytes (0/1) 0%
Endocrine Physiology (3/3) 100%
Evidence Based Medicine (1/3) 33%
Statistics (1/2) 50%
Specific Pathogen Groups (1/2) 50%
Renal Physiology (2/2) 100%
Respiratory (1/1) 100%
Principles Of Microbiology (1/1) 100%
General Pathology (2/3) 67%
Basic Cellular Physiology (1/1) 100%
Cardiovascular (1/2) 50%
Lower Limb (2/2) 100%
Basic Cellular (1/1) 100%
CNS Pharmacology (2/2) 100%
Upper Limb (1/2) 50%
Principles (1/1) 100%
Infections (2/2) 100%
Endocrine (1/1) 100%
Immunoglobulins And Vaccines (1/1) 100%
Cardiovascular Physiology (1/1) 100%
Renal (1/1) 100%
Passmed