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Question 1
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A 45-year-old woman comes in with a history of fatigue, excessive thirst, and frequent urination. A urine dipstick test is done, which shows the presence of glucose in the urine.
Which ONE result would be INCONSISTENT with a diagnosis of diabetes mellitus in this patient?Your Answer: An HbA1c of 40 mmol/mol
Explanation:According to the 2011 recommendations from the World Health Organization (WHO), HbA1c can now be used as a diagnostic test for diabetes. However, this is only applicable if stringent quality assurance tests are in place and the assays are standardized to criteria aligned with international reference values. Additionally, accurate measurement of HbA1c is only possible if there are no conditions present that could hinder its accuracy.
To diagnose diabetes using HbA1c, a value of 48 mmol/mol (6.5%) is recommended as the cut-off point. It’s important to note that a value lower than 48 mmol/mol (6.5%) does not exclude the possibility of diabetes, as glucose tests are still necessary for a definitive diagnosis.
When using glucose tests, the following criteria are considered diagnostic for diabetes mellitus:
– A random venous plasma glucose concentration greater than 11.1 mmol/l
– A fasting plasma glucose concentration greater than 7.0 mmol/l
– A two-hour plasma glucose concentration greater than 11.1 mmol/l, two hours after consuming 75g of anhydrous glucose in an oral glucose tolerance test (OGTT)However, there are certain circumstances where HbA1c is not appropriate for diagnosing diabetes mellitus. These include:
– ALL children and young people
– Patients of any age suspected of having Type 1 diabetes
– Patients with symptoms of diabetes for less than two months
– Patients at high risk of diabetes who are acutely ill, such as those requiring hospital admission
– Patients taking medication that may cause a rapid rise in glucose levels, such as steroids or antipsychotics
– Patients with acute pancreatic damage, including those who have undergone pancreatic surgery
– Pregnant individuals
– Presence of genetic, hematologic, and illness-related factors that can influence HbA1c and its measurement. -
This question is part of the following fields:
- Endocrinology
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Question 2
Correct
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A 45 year old male presents to the emergency department with complaints of fatigue, headache, muscle spasms, and tingling sensations in the limbs. The patient has no regular medication and no significant medical history. You decide to order blood tests for analysis. The patient's blood results and observations are as follows:
Sodium (Na+): 152 mmol/l
Potassium (K+): 3.3 mmol/l
Urea: 4.0 mmol/l
Creatinine: 71 µmol/l
Blood pressure: 180/96 mmHg
Pulse rate: 80
Respiration rate: 14
Oxygen saturation: 98% on air
Temperature: 36.8ºC
What is the most likely diagnosis?Your Answer: Conn's syndrome
Explanation:Conn’s syndrome, also known as primary hyperaldosteronism, is often characterized by hypertension along with hypokalaemia and hypernatraemia. On the other hand, Addison’s disease typically leads to hypotension, hyponatremia, and hyperkalaemia. Hyponatraemia is commonly associated with pituitary adenoma, while acute renal failure (ARF) is characterized by elevated levels of urea and creatinine, and hyperkalaemia is frequently observed in ARF.
Further Reading:
Hyperaldosteronism is a condition characterized by excessive production of aldosterone by the adrenal glands. It can be classified into primary and secondary hyperaldosteronism. Primary hyperaldosteronism, also known as Conn’s syndrome, is typically caused by adrenal hyperplasia or adrenal tumors. Secondary hyperaldosteronism, on the other hand, is a result of high renin levels in response to reduced blood flow across the juxtaglomerular apparatus.
Aldosterone is the main mineralocorticoid steroid hormone produced by the adrenal cortex. It acts on the distal renal tubule and collecting duct of the nephron, promoting the reabsorption of sodium ions and water while secreting potassium ions.
The causes of hyperaldosteronism vary depending on whether it is primary or secondary. Primary hyperaldosteronism can be caused by adrenal adenoma, adrenal hyperplasia, adrenal carcinoma, or familial hyperaldosteronism. Secondary hyperaldosteronism can be caused by renal artery stenosis, reninoma, renal tubular acidosis, nutcracker syndrome, ectopic tumors, massive ascites, left ventricular failure, or cor pulmonale.
Clinical features of hyperaldosteronism include hypertension, hypokalemia, metabolic alkalosis, hypernatremia, polyuria, polydipsia, headaches, lethargy, muscle weakness and spasms, and numbness. It is estimated that hyperaldosteronism is present in 5-10% of patients with hypertension, and hypertension in primary hyperaldosteronism is often resistant to drug treatment.
Diagnosis of hyperaldosteronism involves various investigations, including U&Es to assess electrolyte disturbances, aldosterone-to-renin plasma ratio (ARR) as the gold standard diagnostic test, ECG to detect arrhythmia, CT/MRI scans to locate adenoma, fludrocortisone suppression test or oral salt testing to confirm primary hyperaldosteronism, genetic testing to identify familial hyperaldosteronism, and adrenal venous sampling to determine lateralization prior to surgery.
Treatment of primary hyperaldosteronism typically involves surgical adrenalectomy for patients with unilateral primary aldosteronism. Diet modification with sodium restriction and potassium supplementation may also be recommended.
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This question is part of the following fields:
- Nephrology
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Question 3
Incorrect
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You assess a patient with nausea, vomiting, restlessness, and palpitations. She is on theophylline for the treatment of her COPD. You suspect toxicity and order blood tests for evaluation.
What is the target range for theophylline levels?Your Answer: 100-200 microgram/mL
Correct Answer: 10-20 mg/L
Explanation:The therapeutic range for theophylline is quite limited, ranging from 10 to 20 micrograms per milliliter (10-20 mg/L). It is important to estimate the plasma concentration of aminophylline during long-term treatment as it can provide valuable information.
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This question is part of the following fields:
- Pharmacology & Poisoning
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Question 4
Incorrect
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A 40-year-old man has a history of a severe headache, high fever, and worsening drowsiness. He recently had flu-like symptoms but his condition deteriorated this morning, prompting his partner to call the GP for a home visit. The man exhibits significant neck stiffness and sensitivity to light, and the GP observes the presence of a petechial rash on his arms and legs. The GP contacts you to arrange for the patient to be transferred to the Emergency Department and requests an ambulance.
What is the MOST appropriate next step for the GP to take in managing this patient?Your Answer: Give IV benzylpenicillin 2.4 g
Correct Answer: Give IM benzylpenicillin 1.2 g
Explanation:This woman is displaying symptoms and signs that are consistent with a diagnosis of meningococcal septicaemia. In the United Kingdom, the majority of cases of meningococcal septicaemia are caused by Neisseria meningitidis group B.
In the prehospital setting, the most suitable medication and method of administration is intramuscular benzylpenicillin 1.2 g. This medication is commonly carried by most General Practitioners and is easier to administer than an intravenous drug in these circumstances.
For close household contacts, prophylaxis can be provided in the form of oral rifampicin 600 mg twice daily for two days.
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This question is part of the following fields:
- Major Incident Management & PHEM
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Question 5
Incorrect
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A 35-year-old individual with a past medical history of constant tiredness and fatigue is scheduled for a complete blood count. The results reveal the presence of microcytic anemia.
What is the most probable underlying diagnosis in this case?Your Answer: Acute haemorrhage
Correct Answer: Thalassaemia
Explanation:Anaemia can be categorized based on the size of red blood cells. Microcytic anaemia, characterized by a mean corpuscular volume (MCV) of less than 80 fl, can be caused by various factors such as iron deficiency, thalassaemia, anaemia of chronic disease (which can also be normocytic), sideroblastic anaemia (which can also be normocytic), lead poisoning, and aluminium toxicity (although this is now rare and mainly affects haemodialysis patients).
On the other hand, normocytic anaemia, with an MCV ranging from 80 to 100 fl, can be attributed to conditions like haemolysis, acute haemorrhage, bone marrow failure, anaemia of chronic disease (which can also be microcytic), mixed iron and folate deficiency, pregnancy, chronic renal failure, and sickle-cell disease.
Lastly, macrocytic anaemia, characterized by an MCV greater than 100 fl, can be caused by factors such as B12 deficiency, folate deficiency, hypothyroidism, reticulocytosis, liver disease, alcohol abuse, myeloproliferative disease, myelodysplastic disease, and certain drugs like methotrexate, hydroxyurea, and azathioprine.
It is important to understand the different causes of anaemia based on red cell size as this knowledge can aid in the diagnosis and management of this condition.
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This question is part of the following fields:
- Haematology
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Question 6
Incorrect
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A 3-year-old girl has consumed a whole packet of ibuprofen tablets that she discovered in her father's bag.
Which of the following symptoms of ibuprofen overdose is more frequently observed in children compared to adults?Your Answer: Tinnitus
Correct Answer: Hypoglycaemia
Explanation:Hyperpyrexia and hypoglycemia are more frequently observed in children than in adults due to salicylate poisoning. Both adults and children may experience common clinical manifestations such as nausea, vomiting, tinnitus, deafness, sweating, dehydration, hyperventilation, and cutaneous flushing. However, it is important to note that xanthopsia is associated with digoxin toxicity, not salicylate poisoning.
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This question is part of the following fields:
- Pharmacology & Poisoning
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Question 7
Correct
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A 7-year-old girl is brought to the Emergency Department by her father with a high temperature and pain in her ear. During the examination, you observe that the mastoid area is red and there is a soft, painful lump in the same spot. You diagnose her with acute mastoiditis, start her on intravenous antibiotics, and refer her to the ENT team on duty.
Which section of the temporal bone is affected in this situation?Your Answer: Petrous part
Explanation:Mastoiditis occurs when a suppurative infection spreads from otitis media, affecting the middle ear, to the mastoid antrum. This infection causes inflammation in the mastoid and surrounding tissues, potentially leading to damage to the bone.
The mastoid antrum, also known as the tympanic antrum, is an air space located in the petrous part of the temporal bone. It connects to the mastoid cells at the back and the epitympanic recess through the aditus to the mastoid antrum.
The mastoid cells come in different types, varying in number and size. There are cellular cells with thin septa, diploeic cells that are marrow spaces with few air cells, and acellular cells that are neither cells nor marrow spaces.
These air spaces serve various functions, including acting as sound receptors, providing voice resonance, offering acoustic insulation and dissipation, protecting against physical damage, and reducing the weight of the cranium.
Overall, mastoiditis occurs when an infection from otitis media spreads to the mastoid antrum, causing inflammation and potential damage to the surrounding tissues and bone. The mastoid antrum and mastoid air cells within the temporal bone play important roles in sound reception, voice resonance, protection, and reducing cranial mass.
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This question is part of the following fields:
- Ear, Nose & Throat
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Question 8
Incorrect
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A 22 year old female presents to the emergency department with symptoms of headache, nausea, and vomiting. The patient has a history of being insulin dependent due to diabetes. Initial tests indicate that the patient is likely experiencing diabetic ketoacidosis. As part of the patient's treatment plan, you order an insulin infusion. What is an expected outcome of administering insulin in this situation?
Your Answer: Decrease intracellular glucose
Correct Answer: Increase blood pH
Explanation:Insulin is known to have several effects on the body. One of its important functions is to increase blood pH. In patients with diabetic ketoacidosis (DKA), their blood pH is low due to acidosis. Insulin helps to correct this by reducing the levels of free fatty acids in the blood, which are responsible for the production of ketone bodies that contribute to acidosis. By doing so, insulin can increase the blood pH.
Additionally, insulin plays a role in regulating glucose levels. It facilitates the movement of glucose from the blood into cells, leading to a decrease in blood glucose levels and an increase in intracellular glucose.
Furthermore, insulin affects the balance of sodium and potassium in the body. It decreases the excretion of sodium by the kidneys and drives potassium from the blood into cells, resulting in a reduction in blood potassium levels. However, it is important to monitor potassium levels closely during insulin infusions, as if they become too low (hypokalemia), the infusion may need to be stopped.
Further Reading:
Diabetic ketoacidosis (DKA) is a serious complication of diabetes that occurs due to a lack of insulin in the body. It is most commonly seen in individuals with type 1 diabetes but can also occur in type 2 diabetes. DKA is characterized by hyperglycemia, acidosis, and ketonaemia.
The pathophysiology of DKA involves insulin deficiency, which leads to increased glucose production and decreased glucose uptake by cells. This results in hyperglycemia and osmotic diuresis, leading to dehydration. Insulin deficiency also leads to increased lipolysis and the production of ketone bodies, which are acidic. The body attempts to buffer the pH change through metabolic and respiratory compensation, resulting in metabolic acidosis.
DKA can be precipitated by factors such as infection, physiological stress, non-compliance with insulin therapy, acute medical conditions, and certain medications. The clinical features of DKA include polydipsia, polyuria, signs of dehydration, ketotic breath smell, tachypnea, confusion, headache, nausea, vomiting, lethargy, and abdominal pain.
The diagnosis of DKA is based on the presence of ketonaemia or ketonuria, blood glucose levels above 11 mmol/L or known diabetes mellitus, and a blood pH below 7.3 or bicarbonate levels below 15 mmol/L. Initial investigations include blood gas analysis, urine dipstick for glucose and ketones, blood glucose measurement, and electrolyte levels.
Management of DKA involves fluid replacement, electrolyte correction, insulin therapy, and treatment of any underlying cause. Fluid replacement is typically done with isotonic saline, and potassium may need to be added depending on the patient’s levels. Insulin therapy is initiated with an intravenous infusion, and the rate is adjusted based on blood glucose levels. Monitoring of blood glucose, ketones, bicarbonate, and electrolytes is essential, and the insulin infusion is discontinued once ketones are below 0.3 mmol/L, pH is above 7.3, and bicarbonate is above 18 mmol/L.
Complications of DKA and its treatment include gastric stasis, thromboembolism, electrolyte disturbances, cerebral edema, hypoglycemia, acute respiratory distress syndrome, and acute kidney injury. Prompt medical intervention is crucial in managing DKA to prevent potentially fatal outcomes.
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This question is part of the following fields:
- Endocrinology
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Question 9
Incorrect
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A 7-year-old boy is brought to the Emergency Department with lower abdominal pain and a high temperature. During the examination, he experiences tenderness in the right iliac fossa, leading to a working diagnosis of acute appendicitis. However, he adamantly refuses to flex his thigh at the hip. When his thigh is passively extended, his abdominal pain intensifies significantly.
What is the probable location of the appendix in this particular patient?Your Answer: Ascending preileal
Correct Answer: Retrocaecal
Explanation:This patient is exhibiting the psoas sign, which is a medical indication of irritation in the iliopsoas group of hip flexors located in the abdomen. In this particular case, it is highly likely that the patient has acute appendicitis.
The psoas sign can be observed by extending the patient’s thigh while they are lying on their side with their knees extended, or by asking the patient to actively flex their thigh at the hip. If these movements result in abdominal pain or if the patient resists due to pain, then the psoas sign is considered positive.
The pain occurs because the psoas muscle is adjacent to the peritoneal cavity. When the muscles are stretched or contracted, they rub against the inflamed tissues nearby, causing discomfort. This strongly suggests that the appendix is positioned retrocaecal.
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This question is part of the following fields:
- Surgical Emergencies
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Question 10
Incorrect
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A 45-year-old woman is brought into the emergency department after a car accident. She has significant bruising on the right side of her chest. You suspect she may have a hemothorax. What clinical signs would you anticipate observing in a patient with a hemothorax?
Your Answer: Widened pulse pressure
Correct Answer: Decreased fremitus on affected side
Explanation:Haemothorax often leads to reduced or absent air entry, a dull percussion sound, and decreased fremitus on the affected side. Commonly observed symptoms in patients with haemothorax include decreased or absent air entry, a dull percussion note when the affected side is tapped, reduced fremitus on the affected side, and in cases of massive haemothorax, tracheal deviation away from the affected side. Other signs that may be present include a rapid heart rate (tachycardia), rapid breathing (tachypnoea), low blood pressure (hypotension), and signs of shock.
Further Reading:
Haemothorax is the accumulation of blood in the pleural cavity of the chest, usually resulting from chest trauma. It can be difficult to differentiate from other causes of pleural effusion on a chest X-ray. Massive haemothorax refers to a large volume of blood in the pleural space, which can impair physiological function by causing blood loss, reducing lung volume for gas exchange, and compressing thoracic structures such as the heart and IVC.
The management of haemothorax involves replacing lost blood volume and decompressing the chest. This is done through supplemental oxygen, IV access and cross-matching blood, IV fluid therapy, and the insertion of a chest tube. The chest tube is connected to an underwater seal and helps drain the fluid, pus, air, or blood from the pleural space. In cases where there is prompt drainage of a large amount of blood, ongoing significant blood loss, or the need for blood transfusion, thoracotomy and ligation of bleeding thoracic vessels may be necessary. It is important to have two IV accesses prior to inserting the chest drain to prevent a drop in blood pressure.
In summary, haemothorax is the accumulation of blood in the pleural cavity due to chest trauma. Managing haemothorax involves replacing lost blood volume and decompressing the chest through various interventions, including the insertion of a chest tube. Prompt intervention may be required in cases of significant blood loss or ongoing need for blood transfusion.
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This question is part of the following fields:
- Trauma
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