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  • Question 1 - A typically healthy 68-year-old man visits the doctor's office complaining of feeling unwell....

    Incorrect

    • A typically healthy 68-year-old man visits the doctor's office complaining of feeling unwell. He mentions experiencing a sharp ache in his right groin. After three days, he develops a strip of painful, red blisters on the top of his right foot.

      What is the most probable diagnosis?

      Your Answer: Kawasaki disease

      Correct Answer: Herpes zoster

      Explanation:

      This individual is experiencing shingles, which is caused by the herpes zoster virus and is characterized by a unique distribution along a specific dermatome.

      Shingles is a painful blistering rash caused by reactivation of the varicella-zoster virus. It is more common in older individuals and those with immunosuppressive conditions. The rash is well demarcated by the affected dermatome and may be accompanied by fever and lethargy. Treatment includes analgesia, antivirals, and potentially oral corticosteroids. Complications include post-herpetic neuralgia, ocular and ear complications. Antivirals should be used within 72 hours to reduce the risk of post-herpetic neuralgia.

    • This question is part of the following fields:

      • Dermatology
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  • Question 2 - A 28-year-old woman with a history of thyroid disorder presents to the clinic...

    Incorrect

    • A 28-year-old woman with a history of thyroid disorder presents to the clinic with concerns about darkened skin on her neck.
      Which of the following is the most probable cause?

      Your Answer: Intertrigo

      Correct Answer: Acanthosis nigricans

      Explanation:

      Common Skin Conditions: A Brief Overview

      Acanthosis Nigricans: A condition characterized by darkened patches of thickened skin, often described as velvet-like. It is usually benign but can sometimes be associated with underlying autoimmune conditions or gastric cancer.

      Dermatitis: Inflammation of the skin that can cause blistering, oozing, crusting, or flaking. Examples include eczema, dandruff, and rashes caused by contact with certain substances.

      Hidradenitis Suppurativa: A chronic condition that affects the apocrine glands in skin folds, causing painful nodules that can develop into pustules and eventually rupture. Scarring is common.

      Intertrigo: An inflammatory condition of skin folds caused by friction, often leading to secondary bacterial or fungal infections. Commonly found in the groin, axillae, and inframammary folds.

      Cowden’s Syndrome: An autosomal dominant condition characterized by hair follicle tumors, a cobblestone appearance of the oral epithelium, oral papillomas, and multiple skin tags. Associated with a high incidence of breast, thyroid, and gastrointestinal cancers.

    • This question is part of the following fields:

      • Dermatology
      7.4
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  • Question 3 - A 16-year-old female from Nigeria comes to the clinic with a swelling near...

    Incorrect

    • A 16-year-old female from Nigeria comes to the clinic with a swelling near her earlobe. She had her ears pierced three months ago and has noticed a gradual development of an erythematous swelling. Upon examination, a keloid scar is observed. What is the best course of action for management?

      Your Answer: Advise no treatment is available

      Correct Answer: Refer for intralesional triamcinolone

      Explanation:

      Understanding Keloid Scars

      Keloid scars are abnormal growths that develop from the connective tissue of a scar and extend beyond the boundaries of the original wound. They are more common in people with dark skin and tend to occur in young adults. Keloids are most frequently found on the sternum, shoulder, neck, face, extensor surface of limbs, and trunk.

      To prevent keloid scars, incisions should be made along relaxed skin tension lines. However, if keloids do develop, early treatment with intra-lesional steroids such as triamcinolone may be effective. In some cases, excision may be necessary, but this should be approached with caution as it can potentially lead to further keloid scarring.

      It is important to note that the historical use of Langer lines to determine optimal incision lines has been shown to produce worse cosmetic results than following skin tension lines. Understanding the predisposing factors and treatment options for keloid scars can help individuals make informed decisions about their care.

    • This question is part of the following fields:

      • Dermatology
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  • Question 4 - Which of the following is not typically associated with hirsutism in individuals? ...

    Correct

    • Which of the following is not typically associated with hirsutism in individuals?

      Your Answer: Porphyria cutanea tarda

      Explanation:

      Hypertrichosis is the result of Porphyria cutanea tarda, not hirsutism.

      Understanding Hirsutism and Hypertrichosis

      Hirsutism and hypertrichosis are two conditions that involve excessive hair growth in women. Hirsutism is typically caused by androgen-dependent hair growth, while hypertrichosis is caused by androgen-independent hair growth. The most common cause of hirsutism is polycystic ovarian syndrome, but it can also be caused by other conditions such as Cushing’s syndrome, congenital adrenal hyperplasia, and obesity. Hypertrichosis, on the other hand, can be caused by drugs like minoxidil and ciclosporin, as well as congenital conditions like hypertrichosis lanuginosa and terminalis.

      To assess hirsutism, doctors use the Ferriman-Gallwey scoring system, which assigns scores to nine different body areas. A score of over 15 is considered to indicate moderate or severe hirsutism. Management of hirsutism typically involves weight loss if the patient is overweight, as well as cosmetic techniques like waxing and bleaching. Combined oral contraceptive pills like co-cyprindiol and ethinylestradiol and drospirenone may also be used, but co-cyprindiol should not be used long-term due to the increased risk of venous thromboembolism. For facial hirsutism, topical eflornithine may be used, but it is contraindicated in pregnancy and breastfeeding.

      Overall, understanding the causes and management of hirsutism and hypertrichosis is important for women who experience excessive hair growth. By working with their doctors, they can find the best treatment options to manage their symptoms and improve their quality of life.

    • This question is part of the following fields:

      • Dermatology
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  • Question 5 - A 32-year-old male patient comes in for mole removal. Which areas of the...

    Correct

    • A 32-year-old male patient comes in for mole removal. Which areas of the body are more prone to developing keloid scars?

      Your Answer: Sternum

      Explanation:

      Understanding Keloid Scars

      Keloid scars are abnormal growths that develop from the connective tissue of a scar and extend beyond the boundaries of the original wound. They are more common in people with dark skin and tend to occur in young adults. Keloids are most frequently found on the sternum, shoulder, neck, face, extensor surface of limbs, and trunk.

      To prevent keloid scars, incisions should be made along relaxed skin tension lines. However, if keloids do develop, early treatment with intra-lesional steroids such as triamcinolone may be effective. In some cases, excision may be necessary, but this should be approached with caution as it can potentially lead to further keloid scarring.

      It is important to note that the historical use of Langer lines to determine optimal incision lines has been shown to produce worse cosmetic results than following skin tension lines. Understanding the predisposing factors and treatment options for keloid scars can help individuals make informed decisions about their care.

    • This question is part of the following fields:

      • Dermatology
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  • Question 6 - A 45-year-old man visits his GP with a lump on the side of...

    Incorrect

    • A 45-year-old man visits his GP with a lump on the side of his head. During the examination, the GP suspects that the lump may be a basal cell carcinoma. What characteristic is most indicative of this diagnosis?

      Your Answer: Crusted edges

      Correct Answer: Telangiectasia

      Explanation:

      Understanding Basal Cell Carcinomas: Symptoms and Diagnosis

      Basal cell carcinomas are the most common type of non-melanocytic skin carcinoma, typically found in sun-exposed areas of the skin such as the face and neck. They can be familial and associated with certain syndromes. Symptoms of basal cell carcinomas include a slow-growing, skin-colored, pearly nodule with surface telangiectasia, an ulcerated lesion with rolled edges, and crusted edges. Pigmentation is not a predominant feature, but bleeding may occur. Size is not a specific feature of malignancy, but sudden changes in size should be referred to a dermatologist for further assessment and investigation. Diagnosis is confirmed with a biopsy, and treatment involves excision with a clear margin. Recurrence is possible, but basal cell carcinomas rarely metastasize.

    • This question is part of the following fields:

      • Dermatology
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  • Question 7 - A 26-year-old presents with a rash that developed after a camping trip. He...

    Correct

    • A 26-year-old presents with a rash that developed after a camping trip. He mentions being bitten by a tick during the trip. He explains that the rash is red, not itchy, and began at the site of the bite before spreading outward. The center of the rash has now cleared, resulting in a bulls-eye appearance. What is the name of this rash?

      Your Answer: Erythema migrans

      Explanation:

      Lyme Disease: Symptoms and Progression

      Lyme disease is a bacterial infection that is transmitted through the bite of an infected tick. The disease progresses in two stages, with early and later features. The early features of Lyme disease include erythema migrans, which is a small papule that often appears at the site of the tick bite. This papule develops into a larger annular lesion with central clearing, resembling a bulls-eye. This occurs in 70% of patients and is accompanied by systemic symptoms such as malaise, fever, and arthralgia.

      In the later stages of Lyme disease, patients may experience cardiovascular symptoms such as heart block and myocarditis. Neurological symptoms may also occur, including cranial nerve palsies and meningitis. Additionally, patients may develop polyarthritis, which is inflammation in multiple joints. It is important to seek medical attention if any of these symptoms occur after a tick bite, as early treatment can prevent the progression of the disease.

    • This question is part of the following fields:

      • Dermatology
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  • Question 8 - A 55-year-old diabetic female patient comes in with bilateral erythematous lesions on her...

    Correct

    • A 55-year-old diabetic female patient comes in with bilateral erythematous lesions on her shins that have been present for four months. The lesions are surrounded by telangiectasia. What is the probable diagnosis?

      Your Answer: Necrobiosis lipoidica

      Explanation:

      There is no association between erythema nodosum and telangiectasia in the surrounding area.

      Skin Disorders Linked to Diabetes

      Diabetes mellitus is a chronic metabolic disorder that affects various organs in the body, including the skin. Several skin disorders are associated with diabetes, including necrobiosis lipoidica, infections such as candidiasis and staphylococcal, neuropathic ulcers, vitiligo, lipoatrophy, and granuloma annulare. Necrobiosis lipoidica is characterized by shiny, painless areas of yellow, red, or brown skin, typically on the shin, and is often associated with surrounding telangiectasia. Infections such as candidiasis and staphylococcal can also occur in individuals with diabetes. Neuropathic ulcers are a common complication of diabetes, and vitiligo and lipoatrophy are also associated with the condition. Granuloma annulare is a papular lesion that is often slightly hyperpigmented and depressed centrally, but recent studies have not confirmed a significant association between diabetes mellitus and this skin disorder. It is important for individuals with diabetes to be aware of these potential skin complications and to seek medical attention if they notice any changes in their skin.

    • This question is part of the following fields:

      • Dermatology
      11.4
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  • Question 9 - A 36-year-old woman presents to her GP with concerns about facial flushing. She...

    Incorrect

    • A 36-year-old woman presents to her GP with concerns about facial flushing. She reports experiencing random episodes of redness on her face, particularly after consuming alcohol. She also mentions an increase in the number of spots on her cheeks and wonders if these symptoms are related. During the examination, the GP observes two small telangiectasia on the nose and left cheek, as well as a few small papules on each cheek. What management options should the GP suggest to alleviate the patient's symptoms?

      Your Answer: Topical fusidic acid

      Correct Answer: Topical metronidazole

      Explanation:

      For the treatment of mild to moderate acne rosacea, topical metronidazole is recommended. This patient’s symptoms, including flushing and papules, suggest acne rosacea, and as they only have a few telangiectasia and papules, topical metronidazole would be the most appropriate treatment. Laser therapy may be considered for persistent telangiectasia, but it is not necessary at this stage and would likely be arranged by a specialist. Oral isotretinoin is not used to treat acne rosacea and is reserved for severe acne vulgaris, and can only be prescribed by a specialist due to potential harmful side effects. Oral oxytetracycline would be appropriate for more severe cases of acne rosacea with troublesome papules and pustules. Topical fusidic acid is not used to treat acne rosacea but can be used for impetigo.

      Understanding Rosacea: Symptoms and Management

      Rosacea, also known as acne rosacea, is a chronic skin condition that has no known cause. It typically affects the nose, cheeks, and forehead, and the first symptom is often flushing. Over time, telangiectasia (visible blood vessels) may appear, followed by persistent redness with papules and pustules. In some cases, rhinophyma (enlarged nose) may develop, and there may be ocular involvement, such as blepharitis. Sunlight can exacerbate symptoms.

      Mild cases of rosacea may be treated with topical metronidazole, while topical brimonidine gel may be used for patients with predominant flushing but limited telangiectasia. More severe cases may require systemic antibiotics like oxytetracycline. Patients are advised to apply high-factor sunscreen daily and use camouflage creams to conceal redness. Laser therapy may be appropriate for those with prominent telangiectasia, and patients with rhinophyma should be referred to a dermatologist.

      Overall, understanding the symptoms and management of rosacea can help individuals manage their condition and improve their quality of life.

    • This question is part of the following fields:

      • Dermatology
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  • Question 10 - A middle-aged woman comes to you with concerns about skin lesions on her...

    Correct

    • A middle-aged woman comes to you with concerns about skin lesions on her chest. Upon examination, you notice two small red papules with visible fine vessels surrounding them. The lesions blanch when pressure is applied. What commonly used medication could be causing these lesions?

      Your Answer: Combined oral contraceptive

      Explanation:

      Spider naevi are a type of skin angioma that are typically found in the distribution of the superior vena cava. While they can occur without any apparent cause, the presence of multiple lesions may indicate an excess of oestrogen in the body. This is often associated with liver cirrhosis, as the liver is responsible for processing oestrogens. However, it can also occur during pregnancy or as a side effect of oestrogen-containing medications.

      Understanding Spider Naevi

      Spider naevi, also known as spider angiomas, are characterized by a central red papule surrounded by capillaries. These lesions can be identified by their ability to blanch upon pressure. Spider naevi are typically found on the upper part of the body and are more common in childhood, affecting around 10-15% of people.

      To differentiate spider naevi from telangiectasia, one can press on the lesion and observe how it fills. Spider naevi fill from the center, while telangiectasia fills from the edge. It is important to note that spider naevi may be associated with liver disease, pregnancy, and the use of combined oral contraceptive pills.

      In summary, understanding spider naevi is important for proper diagnosis and management. By recognizing their distinct characteristics and potential associations, healthcare professionals can provide appropriate care for their patients.

    • This question is part of the following fields:

      • Dermatology
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  • Question 11 - A 6-year-old boy is presented for surgery after the appearance of multiple small,...

    Incorrect

    • A 6-year-old boy is presented for surgery after the appearance of multiple small, umbilicated lesions on his right leg. He has no prior history of such lesions and is generally healthy, except for a history of allergies. What is the best course of action for management?

      Your Answer: Refer to secondary care

      Correct Answer: Reassure

      Explanation:

      Understanding Molluscum Contagiosum

      Molluscum contagiosum is a viral skin infection that is commonly seen in children, particularly those with atopic eczema. It is caused by the molluscum contagiosum virus and can be transmitted through direct contact or contaminated surfaces. The infection presents as pinkish or pearly white papules with a central umbilication, which can appear anywhere on the body except for the palms of the hands and soles of the feet. In children, lesions are commonly seen on the trunk and in flexures, while in adults, sexual contact may lead to lesions developing on the genitalia, pubis, thighs, and lower abdomen.

      While molluscum contagiosum is a self-limiting condition that usually resolves within 18 months, it is important to avoid sharing towels, clothing, and baths with uninfected individuals to prevent transmission. Scratching the lesions should also be avoided, and treatment may be considered if the itch is problematic. However, treatment is not usually recommended, and if necessary, simple trauma or cryotherapy may be used. In some cases, referral may be necessary, such as for individuals who are HIV-positive with extensive lesions or those with eyelid-margin or ocular lesions and associated red eye.

      Overall, understanding molluscum contagiosum and taking appropriate precautions can help prevent transmission and alleviate symptoms.

    • This question is part of the following fields:

      • Dermatology
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  • Question 12 - A 16-year-old male presents to the dermatology clinic for follow-up. He has a...

    Correct

    • A 16-year-old male presents to the dermatology clinic for follow-up. He has a previous medical history of acne and is currently taking oral lymecycline. Despite treatment, there has been no improvement and upon examination, scarring is evident on his face. What is the most appropriate course of treatment?

      Your Answer: Oral retinoin

      Explanation:

      Referral for oral retinoin is recommended for patients with scarring.

      Acne vulgaris is a common skin condition that typically affects adolescents, with the face, neck, and upper trunk being the most commonly affected areas. It is characterized by the obstruction of hair follicles with keratin plugs, leading to the formation of comedones, inflammation, and pustules. The severity of acne can be classified as mild, moderate, or severe, depending on the presence and extent of inflammatory lesions, papules, and pustules.

      The management of acne vulgaris typically involves a step-up approach, starting with single topical therapy such as topical retinoids or benzoyl peroxide. If this is not effective, topical combination therapy may be used, which includes a topical antibiotic, benzoyl peroxide, and topical retinoid. Oral antibiotics such as tetracyclines may also be prescribed, but they should be avoided in pregnant or breastfeeding women and children under 12 years of age. Erythromycin may be used in pregnancy, while minocycline is now considered less appropriate due to the possibility of irreversible pigmentation. Oral antibiotics should be used for a maximum of three months and always co-prescribed with a topical retinoid or benzoyl peroxide to reduce the risk of antibiotic resistance.

      Combined oral contraceptives (COCP) are an alternative to oral antibiotics in women, and Dianette (co-cyrindiol) may be used as it has anti-androgen properties. However, it has an increased risk of venous thromboembolism compared to other COCPs, so it should generally be used second-line and for only three months. Oral isotretinoin is a potent medication that should only be used under specialist supervision, and it is contraindicated in pregnancy. Finally, there is no evidence to support dietary modification in the management of acne vulgaris.

    • This question is part of the following fields:

      • Dermatology
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  • Question 13 - A 16-year-old female comes to the clinic complaining of a painful and itchy...

    Incorrect

    • A 16-year-old female comes to the clinic complaining of a painful and itchy rash that has rapidly worsened in the last 12 hours. She has a history of atopic dermatitis and hayfever, which have been treated with emollients. Upon examination, she has a monomorphic rash with punched out erosions on her cheeks and bilateral dorsal wrists. The doctors admit her for observation and IV antivirals. What is the most likely pathogen responsible for her condition?

      Your Answer: Herpes zoster

      Correct Answer: Herpes simplex 1

      Explanation:

      Eczema herpeticum is a skin infection primarily caused by herpes simplex virus (HSV) and, in rare cases, coxsackievirus. Herpes zoster leads to chickenpox, roseola is caused by HHV 6, and molluscum contagiosum is caused by poxvirus.

      Understanding Eczema Herpeticum

      Eczema herpeticum is a serious skin infection caused by herpes simplex virus 1 or 2. It is commonly observed in children with atopic eczema and is characterized by a rapidly progressing painful rash. The infection can be life-threatening, which is why it is important to seek medical attention immediately.

      During examination, doctors typically observe monomorphic punched-out erosions, which are circular, depressed, and ulcerated lesions that are usually 1-3 mm in diameter. Due to the severity of the infection, children with eczema herpeticum should be admitted to the hospital for intravenous aciclovir treatment. It is important to understand the symptoms and seek medical attention promptly to prevent any complications.

    • This question is part of the following fields:

      • Dermatology
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  • Question 14 - A 60-year-old man presents with blisters on his skin. He reports that some...

    Incorrect

    • A 60-year-old man presents with blisters on his skin. He reports that some of the blisters have healed and left scars, but others are still growing, and new ones are appearing. Despite taking antibiotics prescribed by his doctor, the blisters have not improved. Upon examination, he has multiple superficial skin lesions and oral ulcers that easily slough off. A skin punch biopsy shows circular intra-epidermal deposits. What other condition is likely to be present in this patient?

      Your Answer: Positive HIV serology

      Correct Answer: Antibodies against desmosomes

      Explanation:

      Understanding Autoimmune Blistering Conditions: Pemphigus Vulgaris and Bullous Pemphigoid

      Pemphigus Vulgaris: Autoimmune Blistering Condition

      Pemphigus vulgaris is an autoimmune blistering condition that primarily affects middle-aged patients. The condition is caused by Immunoglobulin G (IgG) autoantibodies against desmosomal components (desmogleins 1 and 3) of the superficial layers of the skin. This results in flaccid blisters that rupture easily, leading to erosions and scarring. The oral mucosa is often affected early, and Nikolsky’s sign is positive. Immunofluorescence reveals intra-epidermal circular deposits, and antibodies against desmosomes are usually positive. The condition requires aggressive treatment, with high-dose steroids initially used, and life-long maintenance doses often needed. Immunologicals are being trialled.

      Bullous Pemphigoid: Another Autoimmune Blistering Condition

      Bullous pemphigoid is another autoimmune blistering condition that typically affects older patients. The condition is caused by antibodies directed to the deeper basement membrane of the skin. This results in tense, firm, often haemorrhagic blisters that do not rupture easily. Oral lesions are rare, and Nikolsky’s sign is negative. Immunofluorescence reveals linear IgG and C3 deposits along the basement membrane of the skin, and antibodies against hemidesmosomes may be positive. The condition carries significantly less morbidity than pemphigus vulgaris, and topical steroid cream (ex: clobetasol propionate usually suffices).

      No Link to Other Conditions

      There is no link between pemphigus vulgaris or bullous pemphigoid and other conditions such as alopecia, positive HIV serology, or psoriasis. It is important to understand the differences between these autoimmune blistering conditions to ensure proper diagnosis and treatment.

    • This question is part of the following fields:

      • Dermatology
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  • Question 15 - A 28-year-old law student visits his primary care physician complaining of ear pain....

    Incorrect

    • A 28-year-old law student visits his primary care physician complaining of ear pain. He suspects that this is related to the same issue causing dryness in his scalp and beard, as well as eczema-like patches in his nasolabial folds. He has been using non-prescription topical treatments to manage these symptoms but seeks guidance for his earache. What is the probable diagnosis that connects all of this patient's symptoms?

      Your Answer: Eczema herpeticum

      Correct Answer: Seborrhoeic dermatitis

      Explanation:

      Seborrhoeic dermatitis can lead to common complications such as otitis externa and blepharitis. The patient is experiencing eczema-like plaques and dry skin in areas rich in sebum, which he has been treating with over-the-counter antifungal shampoos. However, his complaint of earache may be due to otitis externa, which is associated with seborrhoeic dermatitis. A full ear examination should be performed to rule out other diagnoses. Contact dermatitis is unlikely to present in this distribution and would not cause otalgia. Eczema herpeticum is a severe primary infection by herpes-simplex-virus 1 or 2, commonly seen in children with atopic eczema. Guttate psoriasis commonly affects children after Streptococcal upper respiratory tract infection and will clear over the course of ,3 months without treatment. Irritant dermatitis is unlikely to cause such focal areas of irritation.

      Understanding Seborrhoeic Dermatitis in Adults

      Seborrhoeic dermatitis is a chronic skin condition that affects around 2% of the general population. It is caused by an inflammatory reaction related to the overgrowth of a fungus called Malassezia furfur, which is a normal inhabitant of the skin. The condition is characterized by eczematous lesions that appear on the sebum-rich areas of the body, such as the scalp, periorbital, auricular, and nasolabial folds. It can also lead to the development of otitis externa and blepharitis.

      Seborrhoeic dermatitis is often associated with other medical conditions, such as HIV and Parkinson’s disease. The management of the condition depends on the affected area. For scalp disease, over-the-counter preparations containing zinc pyrithione and tar are usually the first-line treatment. If these are not effective, ketoconazole is the preferred second-line agent. Selenium sulphide and topical corticosteroids may also be useful.

      For the face and body, topical antifungals such as ketoconazole and topical steroids are often used. However, it is important to use steroids for short periods only to avoid side effects. Seborrhoeic dermatitis can be difficult to treat, and recurrences are common. Therefore, it is important to work closely with a healthcare provider to manage the condition effectively.

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      • Dermatology
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  • Question 16 - A 50-year-old woman presents to dermatology after being referred by her physician for...

    Correct

    • A 50-year-old woman presents to dermatology after being referred by her physician for lesions on both shins. Upon examination, symmetrical erythematous lesions with an orange peel texture are observed. What is the probable diagnosis?

      Your Answer: Pretibial myxoedema

      Explanation:

      Pretibial myxoedema is a condition characterized by orange peel-like lesions on the skin of the shins, often associated with Grave’s disease.

      Understanding Shin Lesions: Differential Diagnosis and Characteristic Features

      Shin lesions can be caused by a variety of conditions, and it is important to differentiate between them in order to provide appropriate treatment. The four most common conditions that can cause shin lesions are erythema nodosum, pretibial myxoedema, pyoderma gangrenosum, and necrobiosis lipoidica diabeticorum.

      Erythema nodosum is characterized by symmetrical, tender, erythematous nodules that heal without scarring. It is often caused by streptococcal infections, sarcoidosis, inflammatory bowel disease, or certain medications such as penicillins, sulphonamides, or oral contraceptive pills.

      Pretibial myxoedema, on the other hand, is seen in Graves’ disease and is characterized by symmetrical, erythematous lesions that give the skin a shiny, orange peel appearance.

      Pyoderma gangrenosum initially presents as a small red papule, which later develops into deep, red, necrotic ulcers with a violaceous border. It is idiopathic in 50% of cases, but may also be seen in inflammatory bowel disease, connective tissue disorders, and myeloproliferative disorders.

      Finally, necrobiosis lipoidica diabeticorum is characterized by shiny, painless areas of yellow/red skin typically found on the shin of diabetics. It is often associated with telangiectasia.

      In summary, understanding the differential diagnosis and characteristic features of shin lesions can help healthcare professionals provide appropriate treatment and improve patient outcomes.

    • This question is part of the following fields:

      • Dermatology
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  • Question 17 - A 56-year-old man with a history of type 2 diabetes mellitus and benign...

    Incorrect

    • A 56-year-old man with a history of type 2 diabetes mellitus and benign prostatic hyperplasia presents to dermatology with multiple lesions on his shin. Upon examination, symmetrical, tender, erythematous nodules are observed. The lesions are healing without scarring. What is the probable diagnosis?

      Your Answer: Necrobiosis lipoidica diabeticorum

      Correct Answer: Erythema nodosum

      Explanation:

      The relevant diagnosis for this question relies solely on the description of the lesions, as the patient’s medical history is not a factor. Specifically, the tender shin lesions are indicative of erythema nodosum.

      Understanding Shin Lesions: Differential Diagnosis and Characteristic Features

      Shin lesions can be caused by a variety of conditions, and it is important to differentiate between them in order to provide appropriate treatment. The four most common conditions that can cause shin lesions are erythema nodosum, pretibial myxoedema, pyoderma gangrenosum, and necrobiosis lipoidica diabeticorum.

      Erythema nodosum is characterized by symmetrical, tender, erythematous nodules that heal without scarring. It is often caused by streptococcal infections, sarcoidosis, inflammatory bowel disease, or certain medications such as penicillins, sulphonamides, or oral contraceptive pills.

      Pretibial myxoedema, on the other hand, is seen in Graves’ disease and is characterized by symmetrical, erythematous lesions that give the skin a shiny, orange peel appearance.

      Pyoderma gangrenosum initially presents as a small red papule, which later develops into deep, red, necrotic ulcers with a violaceous border. It is idiopathic in 50% of cases, but may also be seen in inflammatory bowel disease, connective tissue disorders, and myeloproliferative disorders.

      Finally, necrobiosis lipoidica diabeticorum is characterized by shiny, painless areas of yellow/red skin typically found on the shin of diabetics. It is often associated with telangiectasia.

      In summary, understanding the differential diagnosis and characteristic features of shin lesions can help healthcare professionals provide appropriate treatment and improve patient outcomes.

    • This question is part of the following fields:

      • Dermatology
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  • Question 18 - Which of the following skin conditions is not linked to diabetes mellitus? ...

    Incorrect

    • Which of the following skin conditions is not linked to diabetes mellitus?

      Your Answer: Vitiligo

      Correct Answer: Sweet's syndrome

      Explanation:

      Sweet’s syndrome is a condition associated with acute myeloid leukemia, also known as acute febrile neutrophilic dermatosis, but not with diabetes mellitus.

      Skin Disorders Linked to Diabetes

      Diabetes mellitus is a chronic metabolic disorder that affects various organs in the body, including the skin. Several skin disorders are associated with diabetes, including necrobiosis lipoidica, infections such as candidiasis and staphylococcal, neuropathic ulcers, vitiligo, lipoatrophy, and granuloma annulare. Necrobiosis lipoidica is characterized by shiny, painless areas of yellow, red, or brown skin, typically on the shin, and is often associated with surrounding telangiectasia. Infections such as candidiasis and staphylococcal can also occur in individuals with diabetes. Neuropathic ulcers are a common complication of diabetes, and vitiligo and lipoatrophy are also associated with the condition. Granuloma annulare is a papular lesion that is often slightly hyperpigmented and depressed centrally, but recent studies have not confirmed a significant association between diabetes mellitus and this skin disorder. It is important for individuals with diabetes to be aware of these potential skin complications and to seek medical attention if they notice any changes in their skin.

    • This question is part of the following fields:

      • Dermatology
      10.6
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  • Question 19 - A 32-year-old patient with a history of psoriasis complains of redness in the...

    Incorrect

    • A 32-year-old patient with a history of psoriasis complains of redness in the groin and genital region, as well as in the axilla. The patient has previously mentioned a distaste for creams that are messy or difficult to use. What is the best course of treatment?

      Your Answer: Topical calcipotriol

      Correct Answer: Topical steroid

      Explanation:

      Topical steroids are effective in treating flexural psoriasis in this patient.

      NICE recommends a step-wise approach for chronic plaque psoriasis, starting with regular emollients and then using a potent corticosteroid and vitamin D analogue separately, followed by a vitamin D analogue twice daily, and then a potent corticosteroid or coal tar preparation if there is no improvement. Phototherapy, systemic therapy, and topical treatments are also options for management. Topical steroids should be used cautiously and vitamin D analogues may be used long-term. Dithranol and coal tar have adverse effects but can be effective.

    • This question is part of the following fields:

      • Dermatology
      20.2
      Seconds
  • Question 20 - A 29-year-old woman presents with painful, purple lesions on her shins. Which medication...

    Incorrect

    • A 29-year-old woman presents with painful, purple lesions on her shins. Which medication is the most probable cause of this condition?

      Your Answer: Carbimazole

      Correct Answer: Combined oral contraceptive pill

      Explanation:

      Understanding Erythema Nodosum

      Erythema nodosum is a condition characterized by inflammation of the subcutaneous fat, resulting in tender, erythematous, nodular lesions. These lesions typically occur over the shins but may also appear on other parts of the body such as the forearms and thighs. The condition usually resolves within six weeks, and the lesions heal without scarring.

      There are several possible causes of erythema nodosum, including infections such as streptococci, tuberculosis, and brucellosis. Systemic diseases like sarcoidosis, inflammatory bowel disease, and Behcet’s can also lead to the condition. In some cases, erythema nodosum may be associated with malignancy or lymphoma. Certain drugs like penicillins, sulphonamides, and the combined oral contraceptive pill, as well as pregnancy, can also trigger the condition.

      Overall, understanding the causes and symptoms of erythema nodosum is important for prompt diagnosis and treatment.

    • This question is part of the following fields:

      • Dermatology
      6.3
      Seconds
  • Question 21 - A 65-year-old female is referred for management of a chronic ulcer above the...

    Incorrect

    • A 65-year-old female is referred for management of a chronic ulcer above the left medial malleolus. The ankle-brachial pressure index readings are as follows:
      Right 0.95
      Left 0.95
      The ulcer has been treated with standard dressings by the District Nurse. What is the best course of action to increase the chances of healing the ulcer?

      Your Answer: Hydrocolloid dressings

      Correct Answer:

      Explanation:

      Compression bandaging is recommended for the management of venous ulceration, as the ankle-brachial pressure index readings suggest that the ulcers are caused by venous insufficiency rather than arterial issues.

      Venous Ulceration and its Management

      Venous ulceration is a type of ulcer that is commonly seen above the medial malleolus. To assess for poor arterial flow that could impair healing, an ankle-brachial pressure index (ABPI) is important in non-healing ulcers. A normal ABPI is usually between 0.9 – 1.2, while values below 0.9 indicate arterial disease. Interestingly, values above 1.3 may also indicate arterial disease, particularly in diabetics, due to false-negative results caused by arterial calcification.

      The only treatment that has been shown to be of real benefit for venous ulceration is compression bandaging, usually four-layer. Oral pentoxifylline, a peripheral vasodilator, can also improve the healing rate. There is some small evidence supporting the use of flavonoids, but little evidence to suggest benefit from hydrocolloid dressings, topical growth factors, ultrasound therapy, and intermittent pneumatic compression. Proper management of venous ulceration is crucial to promote healing and prevent complications.

    • This question is part of the following fields:

      • Dermatology
      16.8
      Seconds
  • Question 22 - A 20-year-old man is prescribed isotretinoin for severe nodulocystic acne. What is the...

    Correct

    • A 20-year-old man is prescribed isotretinoin for severe nodulocystic acne. What is the most probable side-effect that he may experience?

      Your Answer: Dry skin

      Explanation:

      Understanding Isotretinoin and its Adverse Effects

      Isotretinoin is an oral retinoid that is commonly used to treat severe acne. It has been found that two-thirds of patients who undergo a course of oral isotretinoin experience long-term remission or cure. However, it is important to note that this medication also comes with a number of adverse effects that patients should be aware of.

      One of the most significant adverse effects of isotretinoin is its teratogenicity, which means that it can cause birth defects in developing fetuses. As such, females who are taking this medication should ideally be using two forms of contraception to prevent pregnancy. Other common adverse effects of isotretinoin include dry skin, eyes, and lips/mouth, as well as low mood and depression (although this is a controversial topic). Patients may also experience raised triglycerides, hair thinning, nose bleeds, and photosensitivity.

      It is important for patients to be aware of these potential adverse effects and to discuss any concerns with their healthcare provider. Additionally, patients should always follow their healthcare provider’s instructions for taking isotretinoin and should not combine this medication with tetracyclines due to the risk of intracranial hypertension. By being informed and proactive, patients can help to ensure that they receive the best possible care while taking isotretinoin.

    • This question is part of the following fields:

      • Dermatology
      17.7
      Seconds
  • Question 23 - A 42-year-old man comes in with an ongoing itchy rash that has been...

    Correct

    • A 42-year-old man comes in with an ongoing itchy rash that has been present for a few weeks. During examination, he displays erythematous, scaly lesions beneath his eyebrows, around his nose, and at the top of his chest. He also has a history of dandruff that he manages well with over-the-counter shampoos. What is the best course of treatment for the lesions on his face and trunk?

      Your Answer: Topical ketoconazole

      Explanation:

      Seborrhoeic dermatitis is typically characterized by a scaly rash around the peri-orbital and nasolabial areas, as well as dandruff. The recommended initial treatment is topical ketoconazole.

      Understanding Seborrhoeic Dermatitis in Adults

      Seborrhoeic dermatitis is a chronic skin condition that affects around 2% of the general population. It is caused by an inflammatory reaction related to the overgrowth of a fungus called Malassezia furfur, which is a normal inhabitant of the skin. The condition is characterized by eczematous lesions that appear on the sebum-rich areas of the body, such as the scalp, periorbital, auricular, and nasolabial folds. It can also lead to the development of otitis externa and blepharitis.

      Seborrhoeic dermatitis is often associated with other medical conditions, such as HIV and Parkinson’s disease. The management of the condition depends on the affected area. For scalp disease, over-the-counter preparations containing zinc pyrithione and tar are usually the first-line treatment. If these are not effective, ketoconazole is the preferred second-line agent. Selenium sulphide and topical corticosteroids may also be useful.

      For the face and body, topical antifungals such as ketoconazole and topical steroids are often used. However, it is important to use steroids for short periods only to avoid side effects. Seborrhoeic dermatitis can be difficult to treat, and recurrences are common. Therefore, it is important to work closely with a healthcare provider to manage the condition effectively.

    • This question is part of the following fields:

      • Dermatology
      353.6
      Seconds
  • Question 24 - A 25-year-old woman presents to her General Practitioner concerned about a red, itchy...

    Correct

    • A 25-year-old woman presents to her General Practitioner concerned about a red, itchy rash that developed while she was on holiday in Spain. On examination, she has an inflamed eczematous rash on her face, neck, arms and legs, with a few blisters. She has sparing of skin in areas that have been covered by her swimwear. She is currently being treated for acne and takes no other regular medications. She has no other known medical conditions.
      Which of the following medications is most likely to have caused this patient’s rash?

      Your Answer: Oral lymecycline

      Explanation:

      Understanding Photosensitivity and Acne Treatments

      Photosensitivity is a common side-effect of certain medications used to treat acne. This abnormal reaction to ultraviolet (UV) radiation can cause a rash, particularly when exposed to UVA rays. Primary photosensitive conditions include polymorphic light eruption or solar urticaria, while secondary photosensitivity may be caused by medications such as tetracyclines or retinoids, or exposure to psoralens released by plants.

      Lymecycline, a tetracycline antibiotic commonly used to treat acne, is known to cause photosensitivity. Oral erythromycin, a macrolide antibiotic used to treat acne, does not typically cause photosensitive skin reactions. Topical azelaic acid and clindamycin are also used to treat acne but are not known to cause photosensitivity. Topical benzoyl peroxide may cause local skin reactions but is not associated with photosensitivity. It is important to be aware of the potential side-effects of acne treatments and to take precautions to protect the skin from UV radiation.

    • This question is part of the following fields:

      • Dermatology
      15
      Seconds
  • Question 25 - A 31-year-old female patient visits the GP office with a concerning facial rash....

    Correct

    • A 31-year-old female patient visits the GP office with a concerning facial rash. She reports that the rash worsens after consuming alcohol and has not attempted any treatment before. During the examination, the doctor observes facial erythema, papules, and pustules scattered on the chin and cheeks, and telangiectasia of the lesions. The nasolabial groove is also affected, but there are no comedones. What is the best initial treatment for the probable diagnosis?

      Your Answer: Topical metronidazole

      Explanation:

      For the treatment of mild to moderate acne rosacea, the most appropriate initial option is topical metronidazole. This patient, who presents with erythematous papules and pustules exacerbated by alcohol and telangiectasia, falls under this category. Oral tetracycline can be considered for severe or resistant cases, but it is not necessary for this patient. Oral doxycycline is a second-line treatment option for resistant cases, but it has potential adverse effects such as nausea, diarrhoea, oesophagitis, and increased photosensitivity. Oral isotretinoin and topical adapalene are not indicated for the management of rosacea symptoms and should be avoided. Topical hydrocortisone can even worsen rosacea symptoms and should not be used.

      Understanding Rosacea: Symptoms and Management

      Rosacea, also known as acne rosacea, is a chronic skin condition that has no known cause. It typically affects the nose, cheeks, and forehead, and the first symptom is often flushing. Over time, telangiectasia (visible blood vessels) may appear, followed by persistent redness with papules and pustules. In some cases, rhinophyma (enlarged nose) may develop, and there may be ocular involvement, such as blepharitis. Sunlight can exacerbate symptoms.

      Mild cases of rosacea may be treated with topical metronidazole, while topical brimonidine gel may be used for patients with predominant flushing but limited telangiectasia. More severe cases may require systemic antibiotics like oxytetracycline. Patients are advised to apply high-factor sunscreen daily and use camouflage creams to conceal redness. Laser therapy may be appropriate for those with prominent telangiectasia, and patients with rhinophyma should be referred to a dermatologist.

      Overall, understanding the symptoms and management of rosacea can help individuals manage their condition and improve their quality of life.

    • This question is part of the following fields:

      • Dermatology
      9.7
      Seconds
  • Question 26 - A 67-year-old woman comes to her General Practitioner complaining of severe mucosal ulceration...

    Correct

    • A 67-year-old woman comes to her General Practitioner complaining of severe mucosal ulceration and blistering lesions on her torso and arms. Upon examination, the blisters are flaccid and rupture easily upon contact. What is the most appropriate course of action for this likely diagnosis? Choose the BEST management option from the list below.

      Your Answer: Refer urgently to dermatology

      Explanation:

      Urgent Referral to Dermatology for Pemphigus Vulgaris Treatment

      Pemphigus vulgaris requires urgent referral to the Dermatology Team for investigation and treatment. Supportive measures include wound care and antiseptic regimens to reduce the risk of secondary infection. Patients should also avoid activities that may traumatize the skin and mucous membranes during active phases. Topical steroids are used in milder cases, while systemic corticosteroids with topical treatments are preferred in advanced cases. Emollients and oral antihistamines are not first-line treatments. Topical clobetasone butyrate can be used in mild cases, but referral to Dermatology is still necessary. Topical clotrimazole is not a first-line treatment, and topical dapsone should not be started immediately without further investigation and treatment from Dermatology.

    • This question is part of the following fields:

      • Dermatology
      21.5
      Seconds
  • Question 27 - A 63-year-old man with a recent diagnosis of congestive cardiac failure and a...

    Incorrect

    • A 63-year-old man with a recent diagnosis of congestive cardiac failure and a history of psoriasis visits his GP complaining of a deterioration in his psoriatic plaques. He has been prescribed multiple medications by his cardiologist to alleviate his cardiac symptoms.
      Which of the following newly prescribed medications is the probable cause of this man's psoriasis exacerbation?

      Your Answer: Spironolactone

      Correct Answer: Bisoprolol

      Explanation:

      Psoriatic plaques can be worsened by beta-blockers like bisoprolol, but not by calcium channel blockers like amlodipine or antiplatelet agents like clopidogrel. However, NSAIDs like aspirin can exacerbate psoriasis symptoms. Furosemide, a loop diuretic, has no impact on psoriasis.

      Psoriasis can be worsened by various factors. These include physical trauma, consumption of alcohol, and certain medications such as beta blockers, lithium, antimalarials (chloroquine and hydroxychloroquine), NSAIDs and ACE inhibitors, and infliximab. Additionally, stopping the use of systemic steroids can also exacerbate psoriasis. It is important to note that streptococcal infection can trigger guttate psoriasis, a type of psoriasis characterized by small, drop-like lesions on the skin. Therefore, individuals with psoriasis should be aware of these exacerbating factors and take necessary precautions to manage their condition.

    • This question is part of the following fields:

      • Dermatology
      16.6
      Seconds
  • Question 28 - A 25-year-old male patient comes to you with concerns about changes in his...

    Incorrect

    • A 25-year-old male patient comes to you with concerns about changes in his axillary skin. He reports feeling otherwise healthy and denies any other symptoms. Upon examination, you observe thickened and darkened skin in the axillary creases. The patient's BMI is 38 kg/m² and his blood pressure is within normal limits. What is the probable diagnosis?

      Your Answer: Candida

      Correct Answer: Acanthosis nigricans

      Explanation:

      A thickened brown velvety patch of skin, often accompanied by skin tags, is a common sign of Acanthosis nigricans (AN). This condition is typically found in the axilla, groin, and back of the neck. However, AN is not a standalone condition, but rather a cutaneous sign of underlying disease. The most common type of AN is associated with obesity and insulin resistance. Other underlying conditions linked to AN include Cushing’s syndrome, polycystic ovary syndrome, and certain medications such as nicotinic acid, insulin, and systemic corticosteroids. In rare cases, AN may indicate an underlying malignancy, particularly stomach cancer. Therefore, it is crucial to consider this possibility when making a diagnosis.

      Acanthosis nigricans is a condition characterized by the presence of symmetrical, brown, velvety plaques on the neck, axilla, and groin. This condition can be caused by various factors such as type 2 diabetes mellitus, gastrointestinal cancer, obesity, polycystic ovarian syndrome, acromegaly, Cushing’s disease, hypothyroidism, familial factors, Prader-Willi syndrome, and certain drugs like the combined oral contraceptive pill and nicotinic acid. The pathophysiology of acanthosis nigricans involves insulin resistance, which leads to hyperinsulinemia. This, in turn, stimulates the proliferation of keratinocytes and dermal fibroblasts through interaction with insulin-like growth factor receptor-1 (IGFR1).

    • This question is part of the following fields:

      • Dermatology
      49.6
      Seconds
  • Question 29 - A 56-year-old Caucasian man presents with a rash on the face. He first...

    Correct

    • A 56-year-old Caucasian man presents with a rash on the face. He first noticed this six months ago when he experienced episodes of flushing on the face. This has often occurred after he had alcohol or in situations where he felt stressful. A month ago, he started noticing a rash on his cheeks which came on intermittently until three weeks ago when the rash has become permanent. There has been no pain or itch associated with the rash. He is otherwise fit and well. He does not smoke.

      On examination of the face, there is marked erythema with papules, pustules and telangiectasia. There are no comedones seen. The rash is distributed across the cheeks and nose. There is no per-oral or peri-orbital involvement.

      What is the most likely diagnosis?

      Your Answer: Acne rosacea

      Explanation:

      The features described suggest acne rosacea, with episodic flushing, papules and pustules with telangiectasia on the nose, cheeks and forehead. Other conditions such as acne vulgaris, systemic lupus erythematosus, seborrhoeic dermatitis and shingles are unlikely based on the described symptoms.

      Understanding Rosacea: Symptoms and Management

      Rosacea, also known as acne rosacea, is a chronic skin condition that has no known cause. It typically affects the nose, cheeks, and forehead, and the first symptom is often flushing. Over time, telangiectasia (visible blood vessels) may appear, followed by persistent redness with papules and pustules. In some cases, rhinophyma (enlarged nose) may develop, and there may be ocular involvement, such as blepharitis. Sunlight can exacerbate symptoms.

      Mild cases of rosacea may be treated with topical metronidazole, while topical brimonidine gel may be used for patients with predominant flushing but limited telangiectasia. More severe cases may require systemic antibiotics like oxytetracycline. Patients are advised to apply high-factor sunscreen daily and use camouflage creams to conceal redness. Laser therapy may be appropriate for those with prominent telangiectasia, and patients with rhinophyma should be referred to a dermatologist.

      Overall, understanding the symptoms and management of rosacea can help individuals manage their condition and improve their quality of life.

    • This question is part of the following fields:

      • Dermatology
      12
      Seconds
  • Question 30 - A 65-year-old man with a history of Parkinson's disease comes to the clinic...

    Correct

    • A 65-year-old man with a history of Parkinson's disease comes to the clinic complaining of an itchy, red rash on his neck, behind his ears, and around the nasolabial folds. He experienced a similar outbreak last year but did not seek medical attention. What is the probable diagnosis?

      Your Answer: Seborrhoeic dermatitis

      Explanation:

      Patients with Parkinson’s disease are more likely to experience seborrhoeic dermatitis.

      Understanding Seborrhoeic Dermatitis in Adults

      Seborrhoeic dermatitis is a chronic skin condition that affects around 2% of the general population. It is caused by an inflammatory reaction related to the overgrowth of a fungus called Malassezia furfur, which is a normal inhabitant of the skin. The condition is characterized by eczematous lesions that appear on the sebum-rich areas of the body, such as the scalp, periorbital, auricular, and nasolabial folds. It can also lead to the development of otitis externa and blepharitis.

      Seborrhoeic dermatitis is often associated with other medical conditions, such as HIV and Parkinson’s disease. The management of the condition depends on the affected area. For scalp disease, over-the-counter preparations containing zinc pyrithione and tar are usually the first-line treatment. If these are not effective, ketoconazole is the preferred second-line agent. Selenium sulphide and topical corticosteroids may also be useful.

      For the face and body, topical antifungals such as ketoconazole and topical steroids are often used. However, it is important to use steroids for short periods only to avoid side effects. Seborrhoeic dermatitis can be difficult to treat, and recurrences are common. Therefore, it is important to work closely with a healthcare provider to manage the condition effectively.

    • This question is part of the following fields:

      • Dermatology
      16.1
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

Dermatology (14/30) 47%
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