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  • Question 1 - A 55-year-old man complains of persistent itching caused by shiny, flat-topped papules on...

    Correct

    • A 55-year-old man complains of persistent itching caused by shiny, flat-topped papules on the palmar aspect of his wrists. Lichen planus is suspected. What is the best course of treatment?

      Your Answer: Topical clobetasone butyrate

      Explanation:

      Understanding Lichen Planus

      Lichen planus is a skin condition that is believed to be caused by an immune response, although the exact cause is unknown. It is characterized by an itchy, papular rash that typically appears on the palms, soles, genitalia, and flexor surfaces of the arms. The rash often has a polygonal shape and a distinctive white-lines pattern on the surface, known as Wickham’s striae. In some cases, new skin lesions may appear at the site of trauma, a phenomenon known as the Koebner phenomenon.

      Oral involvement is common in around 50% of patients, with a white-lace pattern often appearing on the buccal mucosa. Nail changes may also occur, including thinning of the nail plate and longitudinal ridging. Lichenoid drug eruptions can be caused by certain medications, such as gold, quinine, and thiazides.

      The main treatment for lichen planus is potent topical steroids. For oral lichen planus, benzydamine mouthwash or spray is recommended. In more extensive cases, oral steroids or immunosuppression may be necessary.

    • This question is part of the following fields:

      • Dermatology
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  • Question 2 - A 50-year-old woman comes in for a check-up. She has recently noticed several...

    Correct

    • A 50-year-old woman comes in for a check-up. She has recently noticed several areas of pale skin on her hands. Despite using an emollient and topical hydrocortisone, there has been no improvement. During the examination, you observe multiple depigmented patches on the back of both hands. The patient's medical history includes a previous diagnosis of thyrotoxicosis, for which she is currently taking carbimazole and thyroxine. What is the probable reason for her symptoms?

      Your Answer: Vitiligo

      Explanation:

      Patients with autoimmune conditions like thyrotoxicosis are more likely to have vitiligo, but there are no other indications in the medical history that point towards Addison’s disease.

      Understanding Vitiligo

      Vitiligo is a condition that affects the skin, resulting in the loss of melanocytes and causing depigmentation. It is an autoimmune disorder that affects approximately 1% of the population, with symptoms typically appearing between the ages of 20-30 years. The condition is characterized by well-defined patches of depigmented skin, with the peripheries being the most affected. Trauma can also trigger new lesions, known as the Koebner phenomenon.

      Vitiligo is often associated with other autoimmune disorders such as type 1 diabetes mellitus, Addison’s disease, autoimmune thyroid disorders, pernicious anemia, and alopecia areata. Management of the condition includes the use of sunblock for affected areas of skin, camouflage make-up, and topical corticosteroids, which may reverse the changes if applied early. There may also be a role for topical tacrolimus and phototherapy, although caution needs to be exercised with light-skinned patients.

      In summary, vitiligo is a condition that affects the skin, resulting in depigmentation. It is an autoimmune disorder that can be managed with various treatments, including sunblock, make-up, and topical corticosteroids. It is often associated with other autoimmune disorders, and caution should be exercised when using certain treatments.

    • This question is part of the following fields:

      • Dermatology
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  • Question 3 - A 28-year-old woman presents with a recurring, intensely itchy rash on the palms...

    Incorrect

    • A 28-year-old woman presents with a recurring, intensely itchy rash on the palms of her hands. She reports that these rashes tend to occur every summer. Despite trying over-the-counter emollients and antihistamines, there has been only marginal improvement. The patient is otherwise healthy with no other medical conditions and does not smoke.

      During examination, bilateral vesicles are observed on the palms and sides of the fingers. The palms appear dry with areas of skin peeling, while the rest of her body is unaffected.

      What is the most probable diagnosis?

      Your Answer: Scabies

      Correct Answer: Pompholyx eczema

      Explanation:

      Palmoplantar pustulosis is often accompanied by psoriasis on other areas of the body and is strongly linked to smoking. Unlike pompholyx eczema, the connection to high temperatures and humidity is not as significant. Scabies, which is caused by the parasite Sarcoptes scabiei, results in severe itching of the hands and web spaces but is typically not a recurring issue. Symptoms include linear burrows and erythematous papules rather than vesicles.

      Understanding Pompholyx Eczema

      Pompholyx eczema, also known as dyshidrotic eczema, is a type of skin condition that affects both the hands and feet. It is often triggered by high temperatures and humidity, such as sweating. The main symptom of pompholyx eczema is the appearance of small blisters on the palms and soles, which can be intensely itchy and sometimes accompanied by a burning sensation. Once the blisters burst, the skin may become dry and crack.

      To manage pompholyx eczema, cool compresses and emollients can be used to soothe the affected areas. Topical steroids may also be prescribed to reduce inflammation and itching. It is important to avoid further irritation by wearing gloves or protective footwear and avoiding exposure to irritants. With proper management, the symptoms of pompholyx eczema can be controlled and minimized.

    • This question is part of the following fields:

      • Dermatology
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  • Question 4 - A 5-year-old boy is brought to surgery by his father who has noticed...

    Incorrect

    • A 5-year-old boy is brought to surgery by his father who has noticed a number of small 'spots' and 'bruises' on his legs that have developed over the past 2-3 days. He initially thought this was due to an allergy but it has not gone away. His son is described as being well apart from a cough he's had for the past 2 weeks.

      On examination, he is apyrexial with a heart rate of 98/min. Examination of his ears, throat and chest is normal. There is no neck stiffness or abdominal masses. A number of petechiae are seen around his chest area as well as purpura on his lower legs and arms.

      What is the most appropriate action?

      Your Answer: Arrange a full blood count on the paediatric ward within the next 2 days

      Correct Answer: Admit immediately to paediatrics

      Explanation:

      If a child develops purpura suddenly, it is crucial to refer them for urgent investigations to rule out meningococcal disease and ALL. Although petechiae may occur in viral infections or due to increased pressure in the superior vena cava, purpura is never a normal finding in children. Therefore, immediate admission is necessary to exclude any serious underlying condition. In case of suspicion of meningococcal septicaemia, antibiotics should be administered parenterally without delaying transfer.

      Understanding Purpura: Causes and Symptoms

      Purpura is a medical condition characterized by bleeding into the skin from small blood vessels, resulting in a non-blanching rash. It is often caused by low platelets, but it can also be associated with bleeding disorders such as von Willebrand disease. In addition to the rash, smaller petechiae may also be present, which are tiny red or purple spots on the skin.

      It is crucial to recognize purpura as it can indicate the presence of serious underlying diseases. In children, a new purpuric rash should be treated as an emergency and investigated immediately, as it may be a sign of meningococcal septicaemia or acute lymphoblastic leukaemia. If meningococcal septicaemia is suspected, parenteral antibiotics should be given before transfer.

      The causes of purpura can vary depending on the age group. In children, it can be caused by meningococcal septicaemia, acute lymphoblastic leukaemia, congenital bleeding disorders, immune thrombocytopenic purpura, Henoch-Schonlein purpura, or non-accidental injury. In adults, it can be caused by immune thrombocytopenic purpura, bone marrow failure (secondary to leukaemias, myelodysplasia, or bone metastases), senile purpura, drugs (quinine, antiepileptics, antithrombotics), or nutritional deficiencies (vitamins B12, C, and folate).

    • This question is part of the following fields:

      • Dermatology
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  • Question 5 - A 60-year-old man presents with blisters on his skin. He reports that some...

    Incorrect

    • A 60-year-old man presents with blisters on his skin. He reports that some of the blisters have healed and left scars, but others are still growing, and new ones are appearing. Despite taking antibiotics prescribed by his doctor, the blisters have not improved. Upon examination, he has multiple superficial skin lesions and oral ulcers that easily slough off. A skin punch biopsy shows circular intra-epidermal deposits. What other condition is likely to be present in this patient?

      Your Answer: Positive HIV serology

      Correct Answer: Antibodies against desmosomes

      Explanation:

      Understanding Autoimmune Blistering Conditions: Pemphigus Vulgaris and Bullous Pemphigoid

      Pemphigus Vulgaris: Autoimmune Blistering Condition

      Pemphigus vulgaris is an autoimmune blistering condition that primarily affects middle-aged patients. The condition is caused by Immunoglobulin G (IgG) autoantibodies against desmosomal components (desmogleins 1 and 3) of the superficial layers of the skin. This results in flaccid blisters that rupture easily, leading to erosions and scarring. The oral mucosa is often affected early, and Nikolsky’s sign is positive. Immunofluorescence reveals intra-epidermal circular deposits, and antibodies against desmosomes are usually positive. The condition requires aggressive treatment, with high-dose steroids initially used, and life-long maintenance doses often needed. Immunologicals are being trialled.

      Bullous Pemphigoid: Another Autoimmune Blistering Condition

      Bullous pemphigoid is another autoimmune blistering condition that typically affects older patients. The condition is caused by antibodies directed to the deeper basement membrane of the skin. This results in tense, firm, often haemorrhagic blisters that do not rupture easily. Oral lesions are rare, and Nikolsky’s sign is negative. Immunofluorescence reveals linear IgG and C3 deposits along the basement membrane of the skin, and antibodies against hemidesmosomes may be positive. The condition carries significantly less morbidity than pemphigus vulgaris, and topical steroid cream (ex: clobetasol propionate usually suffices).

      No Link to Other Conditions

      There is no link between pemphigus vulgaris or bullous pemphigoid and other conditions such as alopecia, positive HIV serology, or psoriasis. It is important to understand the differences between these autoimmune blistering conditions to ensure proper diagnosis and treatment.

    • This question is part of the following fields:

      • Dermatology
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  • Question 6 - A 58-year-old with a history of acne rosacea seeks guidance on treatment options....

    Incorrect

    • A 58-year-old with a history of acne rosacea seeks guidance on treatment options. Which of the following interventions is least helpful in managing the condition?

      Your Answer:

      Correct Answer: Low-dose topical corticosteroids

      Explanation:

      Understanding Rosacea: Symptoms and Management

      Rosacea, also known as acne rosacea, is a chronic skin condition that has no known cause. It typically affects the nose, cheeks, and forehead, and the first symptom is often flushing. Over time, telangiectasia (visible blood vessels) may appear, followed by persistent redness with papules and pustules. In some cases, rhinophyma (enlarged nose) may develop, and there may be ocular involvement, such as blepharitis. Sunlight can exacerbate symptoms.

      Mild cases of rosacea may be treated with topical metronidazole, while topical brimonidine gel may be used for patients with predominant flushing but limited telangiectasia. More severe cases may require systemic antibiotics like oxytetracycline. Patients are advised to apply high-factor sunscreen daily and use camouflage creams to conceal redness. Laser therapy may be appropriate for those with prominent telangiectasia, and patients with rhinophyma should be referred to a dermatologist.

      Overall, understanding the symptoms and management of rosacea can help individuals manage their condition and improve their quality of life.

    • This question is part of the following fields:

      • Dermatology
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  • Question 7 - A toddler is brought to your clinic as the mother has noticed some...

    Incorrect

    • A toddler is brought to your clinic as the mother has noticed some skin lesions on the child's face. Upon examination, you observe multiple small white papules on the nose. What is the probable diagnosis?

      Your Answer:

      Correct Answer: Milia

      Explanation:

      Milia, which are often found on the face of newborns, are a normal occurrence and can be seen in up to 50% of babies. They typically disappear on their own within a few weeks.

      Understanding Milia: Small, Benign Cysts on the Face

      Milia are small cysts that are filled with keratin and are typically found on the face. These cysts are benign and are not harmful to one’s health. Although they can appear at any age, they are more commonly found in newborns. Milia are often described as small, white bumps that are painless and do not cause any discomfort.

      While the exact cause of milia is unknown, they are thought to occur when dead skin cells become trapped in the skin’s surface. They can also develop as a result of using heavy skin care products or as a side effect of certain medications. In most cases, milia will disappear on their own without any treatment. However, if they persist or become bothersome, a dermatologist may recommend treatment options such as extraction or chemical peels.

    • This question is part of the following fields:

      • Dermatology
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  • Question 8 - You are examining a 7-month-old infant who has a capillary haemangioma located on...

    Incorrect

    • You are examining a 7-month-old infant who has a capillary haemangioma located on the right cheek that is beginning to interfere with their vision. Following a conversation with the parents, you have decided to initiate treatment for this area due to the potential impact on eyesight.

      What is the primary treatment option for capillary haemangioma?

      Your Answer:

      Correct Answer: Propranolol

      Explanation:

      When it comes to capillary haemangiomas that require intervention, the preferred treatment is propranolol. Other options include laser therapy or systemic steroids, but topical steroids are unlikely to be effective. Surgery is generally not recommended for most cases.

      Understanding Strawberry Naevus

      Strawberry naevus, also known as capillary haemangioma, is a type of skin condition that usually develops in infants within the first month of life. It is characterized by raised, erythematous, and multilobed tumours that commonly appear on the face, scalp, and back. While it is not present at birth, it can grow rapidly and reach its peak size at around 6-9 months before regressing over the next few years. In fact, around 95% of cases resolve before the child reaches 10 years of age. However, there are potential complications that may arise, such as obstructing visual fields or airway, bleeding, ulceration, and thrombocytopaenia.

      Capillary haemangiomas are more common in white infants, particularly in female and premature infants, as well as those whose mothers have undergone chorionic villous sampling. In cases where treatment is necessary, propranolol is now the preferred choice over systemic steroids. Topical beta-blockers like timolol may also be used. It is important to note that there is a deeper type of capillary haemangioma called cavernous haemangioma. Understanding the nature of strawberry naevus is crucial in managing its potential complications and providing appropriate treatment.

    • This question is part of the following fields:

      • Dermatology
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  • Question 9 - You assess a 23-year-old male patient who has newly developed extensive psoriatic plaques...

    Incorrect

    • You assess a 23-year-old male patient who has newly developed extensive psoriatic plaques on his elbows and knees. He has no prior history of skin issues, but his mother has a history of psoriasis. You suggest using an emollient to manage the scaling. What would be the most suitable initial prescription for treating his plaques?

      Your Answer:

      Correct Answer: Topical steroid + topical calcipotriol

      Explanation:

      As a first-line treatment, NICE suggests using a strong corticosteroid and a vitamin D analogue separately, once a day for up to four weeks. The corticosteroid should be applied in the morning and the vitamin D analogue in the evening.

      NICE recommends a step-wise approach for chronic plaque psoriasis, starting with regular emollients and then using a potent corticosteroid and vitamin D analogue separately, followed by a vitamin D analogue twice daily, and then a potent corticosteroid or coal tar preparation if there is no improvement. Phototherapy, systemic therapy, and topical treatments are also options for management. Topical steroids should be used cautiously and vitamin D analogues may be used long-term. Dithranol and coal tar have adverse effects but can be effective.

    • This question is part of the following fields:

      • Dermatology
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  • Question 10 - A 29-year-old man presents to the emergency department with a 3-day history of...

    Incorrect

    • A 29-year-old man presents to the emergency department with a 3-day history of fever, fatigue, and a tingling sensation in the lateral aspect of his left thigh. The tingling was initially tolerable but has become increasingly painful over the past 24 hours. Upon examination, the area described is erythematous with a macular rash appearing. The patient has a history of HIV and is currently taking antiretroviral therapy with an undetectable viral load. He denies any cough, coryzal symptoms, focal neurological signs, or trauma to the site.

      What is the appropriate management for this patient, given the likely diagnosis? Choose from the options provided.

      Your Answer:

      Correct Answer: Aciclovir

      Explanation:

      Patients suspected of having shingles should receive antiviral treatment within 72 hours of symptom onset, as this can help reduce the risk of post-herpetic complications. In the case of this patient, who is experiencing symptoms of shingles within the 72-hour window and has an immunosuppressive condition, antivirals such as aciclovir should be prescribed. Amitriptyline, which is used to manage post-herpetic neuralgia, would not be appropriate at this stage. Chlorphenamine is typically used to manage itching associated with chickenpox, but as this patient is only experiencing symptoms in one dermatome, it is more likely to be shingles. Flucloxacillin, an antibiotic used to treat bacterial skin infections, would not be appropriate in this case as the patient’s symptoms are consistent with herpes zoster infection.

      Shingles is a painful blistering rash caused by reactivation of the varicella-zoster virus. It is more common in older individuals and those with immunosuppressive conditions. The rash is well demarcated by the affected dermatome and may be accompanied by fever and lethargy. Treatment includes analgesia, antivirals, and potentially oral corticosteroids. Complications include post-herpetic neuralgia, ocular and ear complications. Antivirals should be used within 72 hours to reduce the risk of post-herpetic neuralgia.

    • This question is part of the following fields:

      • Dermatology
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  • Question 11 - You are conducting an 8-week examination on a baby with a prominent purplish...

    Incorrect

    • You are conducting an 8-week examination on a baby with a prominent purplish birthmark. The mother was informed that it may not disappear on its own and could be linked to other vascular issues. What is the probable diagnosis?

      Your Answer:

      Correct Answer: Port wine stain

      Explanation:

      Understanding Port Wine Stains

      Port wine stains are a type of birthmark that are characterized by their deep red or purple color. Unlike other vascular birthmarks, such as salmon patches and strawberry hemangiomas, port wine stains do not go away on their own and may even become more prominent over time. These birthmarks are typically unilateral, meaning they only appear on one side of the body.

      Fortunately, there are treatment options available for those who wish to reduce the appearance of port wine stains. Cosmetic camouflage can be used to cover up the birthmark, while laser therapy is another option that requires multiple sessions. It’s important to note that while these treatments can help reduce the appearance of port wine stains, they may not completely eliminate them. Understanding the nature of port wine stains and the available treatment options can help individuals make informed decisions about managing these birthmarks.

    • This question is part of the following fields:

      • Dermatology
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  • Question 12 - A 35-year-old man presents to his General Practitioner (GP) with concerns about a...

    Incorrect

    • A 35-year-old man presents to his General Practitioner (GP) with concerns about a mole on his leg. He has noticed over the past few months that it has increased in size. On examination, the mole is 7 mm in diameter and has an irregular border but is a consistent colour.
      What is the most appropriate management option for this patient?

      Your Answer:

      Correct Answer: 2-week wait referral to dermatology

      Explanation:

      Understanding Referral Guidelines for Suspicious Pigmented Lesions

      When assessing pigmented lesions, the National Institute of Health and Care Excellence (NICE) recommends using the 7-point scoring system.
      The 7-point checklist includes:
      Major features (2 points each):
      change in size
      irregular shape or border
      irregular colour.
      Minor features (1 point each):
      > 7 mm at greatest diameter
      inflammation
      oozing or crusting
      change in sensation including itch.

      Lesions scoring 3 or more or with other suspicious features of melanoma should be referred urgently via the cancer fast-track pathway to dermatology.

      For lesions with a low suspicion of melanoma, a photo should be taken with a ruler and the patient advised to return in eight weeks for review. However, lesions scoring 5 on the checklist, like those with a change in size, irregular shape or border, and irregular color, should be referred urgently to a dermatologist to avoid any delay in diagnosis and subsequent treatment.

      Excision of lesions suspicious of melanoma should be avoided in primary care as this can delay treatment, and incomplete excision is more common. Routine referral to dermatology would be suitable for a pigmented lesion which scores less than 3 on the 7-point checklist if there are no other features to suggest melanoma. Referral to genetics is recommended if three or more family members have been diagnosed with melanoma.

      It is important to understand these referral guidelines to ensure timely and appropriate management of suspicious pigmented lesions.

    • This question is part of the following fields:

      • Dermatology
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  • Question 13 - A 28-year-old newly qualified nurse presents with a bilateral erythematous rash on both...

    Incorrect

    • A 28-year-old newly qualified nurse presents with a bilateral erythematous rash on both hands. She has recently moved from the Philippines and has no significant medical history. The suspected diagnosis is contact dermatitis. What is the most appropriate test to determine the underlying cause?

      Your Answer:

      Correct Answer: Skin patch test

      Explanation:

      The skin patch test can be beneficial in this scenario as it has the potential to detect irritants in addition to allergens.

      Types of Allergy Tests

      Allergy tests are used to determine if a person has an allergic reaction to a particular substance. There are several types of allergy tests available, each with its own advantages and limitations. The most commonly used test is the skin prick test, which is easy to perform and inexpensive. Drops of diluted allergen are placed on the skin, and a needle is used to pierce the skin. A wheal will typically develop if a patient has an allergy. This test is useful for food allergies and pollen.

      Another type of allergy test is the radioallergosorbent test (RAST), which determines the amount of IgE that reacts specifically with suspected or known allergens. Results are given in grades from 0 (negative) to 6 (strongly positive). This test is useful for food allergies, inhaled allergens (e.g. pollen), and wasp/bee venom.

      Skin patch testing is useful for contact dermatitis. Around 30-40 allergens are placed on the back, and irritants may also be tested for. The patches are removed 48 hours later, and the results are read by a dermatologist after a further 48 hours. Blood tests may be used when skin prick tests are not suitable, for example if there is extensive eczema or if the patient is taking antihistamines. Overall, allergy tests are an important tool in diagnosing and managing allergies.

    • This question is part of the following fields:

      • Dermatology
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  • Question 14 - A 45-year-old man visits his GP with a lump on the side of...

    Incorrect

    • A 45-year-old man visits his GP with a lump on the side of his head. During the examination, the GP suspects that the lump may be a basal cell carcinoma. What characteristic is most indicative of this diagnosis?

      Your Answer:

      Correct Answer: Telangiectasia

      Explanation:

      Understanding Basal Cell Carcinomas: Symptoms and Diagnosis

      Basal cell carcinomas are the most common type of non-melanocytic skin carcinoma, typically found in sun-exposed areas of the skin such as the face and neck. They can be familial and associated with certain syndromes. Symptoms of basal cell carcinomas include a slow-growing, skin-colored, pearly nodule with surface telangiectasia, an ulcerated lesion with rolled edges, and crusted edges. Pigmentation is not a predominant feature, but bleeding may occur. Size is not a specific feature of malignancy, but sudden changes in size should be referred to a dermatologist for further assessment and investigation. Diagnosis is confirmed with a biopsy, and treatment involves excision with a clear margin. Recurrence is possible, but basal cell carcinomas rarely metastasize.

    • This question is part of the following fields:

      • Dermatology
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  • Question 15 - A 28-year-old woman presents to the general practice clinic with a history of...

    Incorrect

    • A 28-year-old woman presents to the general practice clinic with a history of itchy palms and soles for a few weeks. Examination reveals pitting to the nails and dry, scaly, fissured skin with areas of pustules on the palms and soles. She is a social drinker but has no other medical conditions.

      Which of the following is the most likely diagnosis?

      Your Answer:

      Correct Answer: Palmoplantar pustulosis

      Explanation:

      Skin Conditions: Palmoplantar Pustulosis, Bullous Pemphigoid, Contact Dermatitis, Eczema, and Secondary Syphilis

      Palmoplantar Pustulosis: A chronic inflammatory skin condition that affects the palms and soles, often associated with chronic plaque psoriasis and smoking. It presents with painful cracking, fissuring, and crops of sterile pustules that are severely itchy. Topical treatments and phototherapy can be used.

      Bullous Pemphigoid: An autoimmune skin disease that forms large fluid-filled blisters, typically affecting people over 80 years old with underlying neurological or malignant conditions. The age and presenting features in this man are not typical for bullous pemphigoid.

      Contact Dermatitis: A type of eczema triggered by contact with a particular substance, causing a red, dry, and scaly rash only in the areas that have been in contact with the irritant. Pustules are not a feature of this condition, and it would be unusual for an irritant to have been in contact with the palms and soles.

      Eczema: A chronic, itchy, inflammatory skin condition that commonly begins in childhood and affects flexural areas such as behind the knees or in the antecubital fossae. The palms of hands and soles of feet are usually spared.

      Secondary Syphilis: A rash that may appear as rough, red or reddish-brown papules or patches, typically occurring on the trunk but frequently affecting the palms and soles. The rash doesn’t itch and can appear more obvious with physical activity or heat. It resolves spontaneously within several weeks but can recur over the next two years.

    • This question is part of the following fields:

      • Dermatology
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  • Question 16 - A 28-year-old man presents to the emergency department with complaints of severe pain...

    Incorrect

    • A 28-year-old man presents to the emergency department with complaints of severe pain in his perineum and scrotum. He has type 2 diabetes that is currently well managed with dapagliflozin. Upon examination, a purple rash with bullae is observed covering the entire perineum and extending up the scrotum. The patient reports intense pain, but reduced sensation is noted upon palpation of the rash. Vital signs are as follows: BP 110/90 mmHg, heart rate 109bpm, respiration rate 21/minute, temperature 38.1ºC, and oxygen saturation 98% on room air. What is the likely diagnosis?

      Your Answer:

      Correct Answer: Necrotizing fasciitis

      Explanation:

      The patient’s symptoms are consistent with necrotizing fasciitis, which often affects the perineum. The patient is experiencing severe pain, which may be causing his fever and rapid heart and breathing rates. As a type 2 diabetic taking dapagliflozin, an SGLT-2 inhibitor, his risk of developing necrotizing fasciitis is increased. While cellulitis can have similar symptoms in the early stages, the presence of bullae, purple discoloration, and severe pain in a patient with risk factors for necrotizing fasciitis make it less likely. Septic arthritis is not a likely diagnosis as it affects joint spaces, which is not the case in this patient. Pyoderma gangrenosum, which is associated with inflammatory conditions, is not a likely diagnosis as the rash is not ulcerated and the patient has no history of inflammatory bowel disease or rheumatoid arthritis.

      Understanding Necrotising Fasciitis

      Necrotising fasciitis is a serious medical emergency that can be difficult to identify in its early stages. It can be classified into two types based on the causative organism. Type 1 is the most common and is caused by mixed anaerobes and aerobes, often occurring post-surgery in diabetics. Type 2 is caused by Streptococcus pyogenes. There are several risk factors associated with necrotising fasciitis, including recent trauma, burns, or soft tissue infections, diabetes mellitus, intravenous drug use, and immunosuppression. The most commonly affected site is the perineum, also known as Fournier’s gangrene.

      The features of necrotising fasciitis include an acute onset, pain, swelling, and erythema at the affected site. It often presents as rapidly worsening cellulitis with pain that is out of keeping with physical features. The infected tissue is extremely tender and may have hypoaesthesia to light touch. Late signs include skin necrosis and crepitus/gas gangrene. Fever and tachycardia may be absent or occur late in the presentation.

      Management of necrotising fasciitis requires urgent surgical referral for debridement and intravenous antibiotics. The prognosis for this condition is poor, with an average mortality rate of 20%. It is important to be aware of the risk factors and features of necrotising fasciitis to ensure prompt diagnosis and treatment.

    • This question is part of the following fields:

      • Dermatology
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  • Question 17 - A 50-year-old man is brought to the Emergency Department by his wife after...

    Incorrect

    • A 50-year-old man is brought to the Emergency Department by his wife after developing a severe cutaneous hypersensitivity reaction. He has a history of rheumatoid arthritis for which he was taking non-steroidal anti-inflammatory drugs (NSAIDs). Still, his symptoms did not improve, and his rheumatologist prescribed him methotrexate a few days ago.
      On examination, Nikolsky’s sign is present and affects 45% of his body’s surface area.
      What is the underlying condition?

      Your Answer:

      Correct Answer: Toxic epidermal necrolysis

      Explanation:

      Common Skin Hypersensitivity Reactions and their Causes

      Skin hypersensitivity reactions can range from mild to life-threatening. Here are some common types and their causes:

      Toxic Epidermal Necrolysis: This is the most serious skin hypersensitivity reaction, with a high mortality rate. It is usually caused by drugs such as NSAIDs, steroids, methotrexate, allopurinol and penicillins.

      Erythema Multiforme: This is a target-like lesion that commonly occurs on the palms and soles. It is usually caused by drugs such as penicillins, phenytoin, NSAIDs and sulfa drugs. Mycoplasma and herpes simplex infections can also cause erythema multiforme.

      Erythema Nodosum: This is an inflammatory condition of subcutaneous tissue. The most common causes are recent streptococcal infection, sarcoidosis, tuberculosis and inflammatory bowel disease.

      Fixed Drug Reaction: This is a localised allergic drug reaction that recurs at the same anatomic site of the skin with repeated drug exposure. It is most commonly caused by aspirin, NSAIDs, tetracycline and barbiturate.

      Morbilliform Rash: This is a mild hypersensitivity skin reaction that manifests as a generalised maculopapular eruption that blanches with pressure. The rash can be caused by penicillin, sulfa drugs, allopurinol and phenytoin.

    • This question is part of the following fields:

      • Dermatology
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  • Question 18 - A 4-year-old boy is brought to the doctor's office because of a rash...

    Incorrect

    • A 4-year-old boy is brought to the doctor's office because of a rash on his upper arm. During the examination, the doctor observes several raised lesions that are approximately 2 mm in diameter. Upon closer inspection, a central dimple is visible in most of the lesions. What is the probable diagnosis?

      Your Answer:

      Correct Answer: Molluscum contagiosum

      Explanation:

      Understanding Molluscum Contagiosum

      Molluscum contagiosum is a viral skin infection that is commonly seen in children, particularly those with atopic eczema. It is caused by the molluscum contagiosum virus and can be transmitted through direct contact or contaminated surfaces. The infection presents as pinkish or pearly white papules with a central umbilication, which can appear anywhere on the body except for the palms of the hands and soles of the feet. In children, lesions are commonly seen on the trunk and in flexures, while in adults, sexual contact may lead to lesions developing on the genitalia, pubis, thighs, and lower abdomen.

      While molluscum contagiosum is a self-limiting condition that usually resolves within 18 months, it is important to avoid sharing towels, clothing, and baths with uninfected individuals to prevent transmission. Scratching the lesions should also be avoided, and treatment may be considered if the itch is problematic. However, treatment is not usually recommended, and if necessary, simple trauma or cryotherapy may be used. In some cases, referral may be necessary, such as for individuals who are HIV-positive with extensive lesions or those with eyelid-margin or ocular lesions and associated red eye.

      Overall, understanding molluscum contagiosum and taking appropriate precautions can help prevent transmission and alleviate symptoms.

    • This question is part of the following fields:

      • Dermatology
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  • Question 19 - A 25-year-old woman who is 14 weeks pregnant complains of worsening acne that...

    Incorrect

    • A 25-year-old woman who is 14 weeks pregnant complains of worsening acne that is causing her distress. Despite using topical benzyl peroxide, she has noticed limited improvement. During examination, non-inflammatory lesions and pustules are observed on her face. What would be the most suitable next course of action?

      Your Answer:

      Correct Answer: Oral erythromycin

      Explanation:

      If treatment for acne is required during pregnancy, oral erythromycin is a suitable option, as the other medications are not recommended.

      Acne vulgaris is a common skin condition that typically affects adolescents, with the face, neck, and upper trunk being the most commonly affected areas. It is characterized by the obstruction of hair follicles with keratin plugs, leading to the formation of comedones, inflammation, and pustules. The severity of acne can be classified as mild, moderate, or severe, depending on the presence and extent of inflammatory lesions, papules, and pustules.

      The management of acne vulgaris typically involves a step-up approach, starting with single topical therapy such as topical retinoids or benzoyl peroxide. If this is not effective, topical combination therapy may be used, which includes a topical antibiotic, benzoyl peroxide, and topical retinoid. Oral antibiotics such as tetracyclines may also be prescribed, but they should be avoided in pregnant or breastfeeding women and children under 12 years of age. Erythromycin may be used in pregnancy, while minocycline is now considered less appropriate due to the possibility of irreversible pigmentation. Oral antibiotics should be used for a maximum of three months and always co-prescribed with a topical retinoid or benzoyl peroxide to reduce the risk of antibiotic resistance.

      Combined oral contraceptives (COCP) are an alternative to oral antibiotics in women, and Dianette (co-cyrindiol) may be used as it has anti-androgen properties. However, it has an increased risk of venous thromboembolism compared to other COCPs, so it should generally be used second-line and for only three months. Oral isotretinoin is a potent medication that should only be used under specialist supervision, and it is contraindicated in pregnancy. Finally, there is no evidence to support dietary modification in the management of acne vulgaris.

    • This question is part of the following fields:

      • Dermatology
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  • Question 20 - An 80-year-old man visits his GP complaining of a painful lesion on his...

    Incorrect

    • An 80-year-old man visits his GP complaining of a painful lesion on his ear that has been bothering him for a year. The lesion has remained the same for several months but is causing him significant discomfort when he lies down. He reports no other symptoms.
      Upon examination, the doctor observes a well-defined, 10mm, flesh-colored nodule on the superior helix of the ear. The nodule is firm, very tender to touch, and covered with some scales.
      What is the most probable diagnosis?

      Your Answer:

      Correct Answer: Chondrodermatitis nodularis helicis

      Explanation:

      Chondrodermatitis nodularis helicis is a painful, non-cancerous nodule that commonly occurs on the ear, particularly in men. Based on the patient’s level of pain and the stable nature of the lesion, this is the most likely diagnosis. While squamous cell carcinoma is a possible differential, it typically progresses more rapidly than this lesion. Similarly, basal cell carcinoma usually develops gradually and is not typically associated with significant pain. Although actinic keratosis can cause a scaly lesion on the ear, it is usually not as painful as chondrodermatitis nodularis helicis and tends to progress slowly over time.

      Understanding Chondrodermatitis Nodularis Helicis

      Chondrodermatitis nodularis helicis (CNH) is a harmless condition that is characterized by the formation of a painful nodule on the ear. It is believed to be caused by various factors such as continuous pressure on the ear, trauma, or exposure to cold. This condition is more prevalent in men and tends to occur more frequently as one ages.

      To manage CNH, it is essential to reduce pressure on the ear. This can be achieved by using foam ear protectors while sleeping. Other treatment options include cryotherapy, steroid injection, and collagen injection. However, surgical treatment may be necessary in some cases, although there is a high likelihood of recurrence.

      Overall, understanding CNH is crucial in managing this condition effectively. By taking the necessary precautions and seeking appropriate treatment, individuals can alleviate the pain and discomfort associated with CNH.

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      • Dermatology
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  • Question 21 - A 72-year-old male presents to his primary care clinic with a 3-day history...

    Incorrect

    • A 72-year-old male presents to his primary care clinic with a 3-day history of burning pain and rash on the right side of his chest. He also complains of feeling generally unwell. He has no significant medical history and is not taking any regular medications.

      During the physical examination, an erythematous rash with multiple clear vesicles is observed on the right side of the torso. The remainder of the clinical examination, including an ophthalmic examination, is unremarkable.

      What is the most appropriate initial management for this patient's most likely diagnosis?

      Your Answer:

      Correct Answer: Prescribe oral famciclovir

      Explanation:

      Patients suspected of having shingles should receive antiviral treatment within 72 hours of symptom onset, according to NICE guidelines. Shingles is diagnosed based on the presence of dermatomal pain and a papular rash, with pain often persisting after the rash has resolved. The recommended first-line oral antivirals are famciclovir or valacyclovir, to be taken for 7 days. Aciclovir is a second-line option, as studies have shown that famciclovir and valacyclovir are more effective in reducing the risk of postherpetic pain. Prescribing calamine lotion and analgesia, as well as monitoring the patient, is not sufficient and does not replace antiviral treatment. Intravenous antivirals are only necessary if the patient cannot tolerate oral medication, and famciclovir cannot be administered intravenously.

      Shingles is a painful blistering rash caused by reactivation of the varicella-zoster virus. It is more common in older individuals and those with immunosuppressive conditions. The rash is well demarcated by the affected dermatome and may be accompanied by fever and lethargy. Treatment includes analgesia, antivirals, and potentially oral corticosteroids. Complications include post-herpetic neuralgia, ocular and ear complications. Antivirals should be used within 72 hours to reduce the risk of post-herpetic neuralgia.

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      • Dermatology
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  • Question 22 - A 65-year-old woman comes to the clinic with a similar concern as the...

    Incorrect

    • A 65-year-old woman comes to the clinic with a similar concern as the previous patient. She has noticed a volcano-like spot on her left arm that has been present for the past 3 months. Initially, she thought it was a simple spot, but it has not gone away. Upon examination, a 5 mm red, raised lesion with a central keratin-filled crater is observed. The doctor suspects a probable keratoacanthoma. What is the most appropriate course of action?

      Your Answer:

      Correct Answer: Urgent referral to dermatology

      Explanation:

      Keratoacanthoma is a benign lesion, but urgent excision is advised due to difficulty in clinically excluding squamous cell carcinoma.

      Understanding Keratoacanthoma

      Keratoacanthoma is a type of non-cancerous tumor that affects the epithelial cells. It is more commonly found in older individuals and is rare in young people. The tumor is characterized by a dome-shaped papule that resembles a volcano or crater. As it grows, it becomes filled with keratin and develops a central crater. While spontaneous regression of keratoacanthoma is common within three months, it often results in scarring. Therefore, it is important to urgently remove such lesions as it is difficult to clinically differentiate them from squamous cell carcinoma. Removal may also prevent scarring.

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      • Dermatology
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  • Question 23 - A 28-year-old man who is HIV positive has been diagnosed with seborrhoeic dermatitis....

    Incorrect

    • A 28-year-old man who is HIV positive has been diagnosed with seborrhoeic dermatitis. What are the two most commonly associated complications with this condition?

      Your Answer:

      Correct Answer: Blepharitis and otitis externa

      Explanation:

      Seborrhoeic dermatitis often leads to otitis externa and blepharitis as complications. Although rare, alopecia may occur if a severe secondary infection develops.

      Understanding Seborrhoeic Dermatitis in Adults

      Seborrhoeic dermatitis is a chronic skin condition that affects around 2% of the general population. It is caused by an inflammatory reaction related to the overgrowth of a fungus called Malassezia furfur, which is a normal inhabitant of the skin. The condition is characterized by eczematous lesions that appear on the sebum-rich areas of the body, such as the scalp, periorbital, auricular, and nasolabial folds. It can also lead to the development of otitis externa and blepharitis.

      Seborrhoeic dermatitis is often associated with other medical conditions, such as HIV and Parkinson’s disease. The management of the condition depends on the affected area. For scalp disease, over-the-counter preparations containing zinc pyrithione and tar are usually the first-line treatment. If these are not effective, ketoconazole is the preferred second-line agent. Selenium sulphide and topical corticosteroids may also be useful.

      For the face and body, topical antifungals such as ketoconazole and topical steroids are often used. However, it is important to use steroids for short periods only to avoid side effects. Seborrhoeic dermatitis can be difficult to treat, and recurrences are common. Therefore, it is important to work closely with a healthcare provider to manage the condition effectively.

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      • Dermatology
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  • Question 24 - A 29-year-old woman presents to her GP with complaints of hair loss. She...

    Incorrect

    • A 29-year-old woman presents to her GP with complaints of hair loss. She reports noticing that her hair has become significantly thinner and that she is shedding more hair than usual, both on her pillow and in the shower drain. She denies any other symptoms and has no significant medical history except for giving birth to her first child 6 months ago. She is not taking any medications regularly and there is no family history of hair loss. On examination, her scalp hair is uniformly thin, but there are no areas of complete hair loss. Her systemic examination is unremarkable and her vital signs are within normal limits. Blood tests, including iron studies and thyroid function, are all normal. What is the most likely diagnosis?

      Your Answer:

      Correct Answer: Telogen effluvium

      Explanation:

      Telogen effluvium is characterized by hair loss and thinning as a result of experiencing significant stress. In this case, the patient’s recent physical stress from giving birth is a likely cause of her hair becoming thinner due to telogen effluvium. The hair loss patterns observed do not match those of alopecia areata or alopecia totalis, which respectively cause distinct areas of complete hair loss or complete loss of all hair on the head and face.

      Input:
      Alopecia may be divided into scarring (destruction of hair follicle) and non-scarring (preservation of hair follicle). Scarring alopecia can be caused by trauma, burns, radiotherapy, lichen planus, discoid lupus, and untreated tinea capitis. Non-scarring alopecia can be caused by male-pattern baldness, drugs such as cytotoxic drugs, carbimazole, heparin, oral contraceptive pill, and colchicine, nutritional deficiencies such as iron and zinc deficiency, autoimmune conditions such as alopecia areata, telogen effluvium, hair loss following a stressful period such as surgery, and trichotillomania.

      Output:
      – Alopecia can be categorized into scarring and non-scarring types.
      – Scarring alopecia is caused by trauma, burns, radiotherapy, lichen planus, discoid lupus, and untreated tinea capitis.
      – Non-scarring alopecia is caused by male-pattern baldness, drugs such as cytotoxic drugs, carbimazole, heparin, oral contraceptive pill, and colchicine, nutritional deficiencies such as iron and zinc deficiency, autoimmune conditions such as alopecia areata, telogen effluvium, hair loss following a stressful period such as surgery, and trichotillomania.

    • This question is part of the following fields:

      • Dermatology
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  • Question 25 - A 28 year-old carpenter complains of itchy and painful skin on his hands...

    Incorrect

    • A 28 year-old carpenter complains of itchy and painful skin on his hands and wrists. He suspects that it might be due to something he is exposed to at work. What test would be most appropriate to investigate this hypothesis?

      Your Answer:

      Correct Answer: Patch testing

      Explanation:

      When there is a suspicion of allergic contact dermatitis, patch testing is the preferred method of investigation. This condition can be caused by either irritants or allergens. The patient’s back is exposed to different allergens, including standard batteries and any substances that the patient suspects. The skin is then evaluated for any reaction after 48 hours and 7 days.

      Understanding Contact Dermatitis

      Contact dermatitis is a skin condition that can be caused by two main types of reactions. The first type is irritant contact dermatitis, which is a non-allergic reaction that occurs due to exposure to weak acids or alkalis, such as detergents. This type of dermatitis is commonly seen on the hands and is characterized by erythema, but crusting and vesicles are rare. The second type is allergic contact dermatitis, which is a type IV hypersensitivity reaction. This type of dermatitis is uncommon and is often seen on the head following hair dyes. It presents as an acute weeping eczema that predominantly affects the margins of the hairline rather than the hairy scalp itself. Topical treatment with a potent steroid is indicated for this type of dermatitis.

      Cement is a frequent cause of contact dermatitis. The alkaline nature of cement may cause an irritant contact dermatitis, while the dichromates in cement can also cause an allergic contact dermatitis. It is important to understand the different types of contact dermatitis and their causes to properly diagnose and treat the condition. Proper treatment can help alleviate symptoms and prevent further complications.

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      • Dermatology
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  • Question 26 - During a routine General Practitioner (GP) clinic, a mother attends with her 8-year-old...

    Incorrect

    • During a routine General Practitioner (GP) clinic, a mother attends with her 8-year-old daughter who has worsening dry, itchy skin, mainly affecting the flexor surfaces, particularly on the legs. She has tried regular liberal use emollient cream with limited success.
      What would be the most appropriate next step in the management of the child’s eczema?

      Your Answer:

      Correct Answer: Prescribe hydrocortisone cream 1%

      Explanation:

      Managing Eczema in Children: Treatment Options and Considerations

      Eczema is a common condition in children that can be effectively managed with the right treatment approach. When a child presents with eczema symptoms, the first step is often to use emollient cream to moisturize the affected area. However, if the symptoms persist or worsen, a topical corticosteroid cream may be prescribed to help manage the flare-up. It is important to use this medication sparingly and in conjunction with emollients.

      If the eczema symptoms continue to be troublesome despite these measures, it may be appropriate to refer the child to a dermatology clinic. However, it is important to note that oral corticosteroids should be used with caution in children and only under the direction of a dermatologist.

      While emollient creams are often effective, in some cases, an emollient ointment may be more moisturizing and helpful. However, if the eczema flare-up is not resolving with emollients alone, a short course of topical corticosteroid is likely necessary.

      Watchful waiting is not appropriate in this situation, as the child has already presented to the GP and symptoms are worsening despite reasonable management by the mother. By understanding the various treatment options and considerations for managing eczema in children, healthcare providers can help ensure the best possible outcomes for their patients.

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      • Dermatology
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  • Question 27 - A 21-year-old woman presents with a rash on her trunk that developed a...

    Incorrect

    • A 21-year-old woman presents with a rash on her trunk that developed a few weeks after a sore throat. On examination, small, drop-shaped, salmon-pink plaques are observed. What is the most probable cause of this rash?

      Your Answer:

      Correct Answer: Guttate psoriasis

      Explanation:

      Understanding Different Skin Conditions: Guttate Psoriasis, Dermatitis, Hand, Foot and Mouth Disease, Pityriasis Rosea, and Pustular Psoriasis

      Skin conditions can be uncomfortable and sometimes even painful. Here are some common skin conditions and their characteristics:

      Guttate psoriasis is a type of psoriasis that causes small, drop-shaped plaques on the chest, arms, legs, and scalp. It is usually caused by a streptococcal infection and can last for up to three months. Topical agents, such as steroids or calcipotriol, can be used to treat it.

      Dermatitis, also known as eczema, results in rough patches of skin that are dry and itchy, particularly with exposure to irritants. In children and adults with long-standing disease, eczema is often localised to the flexure of the limbs.

      Hand, foot and mouth disease (HFMD) is an acute viral illness characterised by vesicular eruptions in the mouth and papulovesicular lesions of the distal limbs. It should not be confused with foot and mouth disease of animals, which is caused by a different virus.

      Pityriasis rosea is a skin rash that is characterised by distinctive, scaly, erythematous lesions. It is thought to be a reaction to exposure to infection.

      Pustular psoriasis is a rarer type of psoriasis that causes pus-filled blisters (pustules) to appear on your skin. Different types of pustular psoriasis affect different parts of the body.

      It is important to consult a healthcare professional for proper diagnosis and treatment of any skin condition.

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      • Dermatology
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  • Question 28 - A 28-year-old patient presents to you with an itchy rash on both elbows...

    Incorrect

    • A 28-year-old patient presents to you with an itchy rash on both elbows that has been getting worse over the past week. Upon examination, you observe multiple flat-topped papular lesions that are polygonal and measure 5mm in diameter on the flexural surface of her elbows bilaterally. There are no other rashes on the rest of her body. What is the most probable diagnosis?

      Your Answer:

      Correct Answer: Lichen planus

      Explanation:

      Understanding Lichen Planus

      Lichen planus is a skin condition that is believed to be caused by an immune response, although the exact cause is unknown. It is characterized by an itchy, papular rash that typically appears on the palms, soles, genitalia, and flexor surfaces of the arms. The rash often has a polygonal shape and a distinctive white-lines pattern on the surface, known as Wickham’s striae. In some cases, new skin lesions may appear at the site of trauma, a phenomenon known as the Koebner phenomenon.

      Oral involvement is common in around 50% of patients, with a white-lace pattern often appearing on the buccal mucosa. Nail changes may also occur, including thinning of the nail plate and longitudinal ridging. Lichenoid drug eruptions can be caused by certain medications, such as gold, quinine, and thiazides.

      The main treatment for lichen planus is potent topical steroids. For oral lichen planus, benzydamine mouthwash or spray is recommended. In more extensive cases, oral steroids or immunosuppression may be necessary.

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      • Dermatology
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  • Question 29 - A 16-year-old female from Nigeria comes to the clinic with a swelling near...

    Incorrect

    • A 16-year-old female from Nigeria comes to the clinic with a swelling near her earlobe. She had her ears pierced three months ago and has noticed a gradual development of an erythematous swelling. Upon examination, a keloid scar is observed. What is the best course of action for management?

      Your Answer:

      Correct Answer: Refer for intralesional triamcinolone

      Explanation:

      Understanding Keloid Scars

      Keloid scars are abnormal growths that develop from the connective tissue of a scar and extend beyond the boundaries of the original wound. They are more common in people with dark skin and tend to occur in young adults. Keloids are most frequently found on the sternum, shoulder, neck, face, extensor surface of limbs, and trunk.

      To prevent keloid scars, incisions should be made along relaxed skin tension lines. However, if keloids do develop, early treatment with intra-lesional steroids such as triamcinolone may be effective. In some cases, excision may be necessary, but this should be approached with caution as it can potentially lead to further keloid scarring.

      It is important to note that the historical use of Langer lines to determine optimal incision lines has been shown to produce worse cosmetic results than following skin tension lines. Understanding the predisposing factors and treatment options for keloid scars can help individuals make informed decisions about their care.

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      • Dermatology
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  • Question 30 - A father brings his 4-year-old daughter to your clinic with worsening eczema. He...

    Incorrect

    • A father brings his 4-year-old daughter to your clinic with worsening eczema. He reports that she has developed itchy blisters all over her body, including her face, torso, arms, and legs. Additionally, she is not behaving normally, eating and drinking less than usual, and not engaging with her favorite toys. She also has a fever of 39ºC. What is the most suitable course of action?

      Your Answer:

      Correct Answer: Refer urgently to hospital

      Explanation:

      Immediate hospitalization and administration of IV antivirals are necessary for the treatment of eczema herpeticum, a severe condition. The child in question is exhibiting symptoms such as painful blisters, fever, and swollen lymph nodes, which require urgent medical attention. Any delay in seeking medical help could worsen the condition. Therefore, all other options are incorrect and should be avoided.

      Understanding Eczema Herpeticum

      Eczema herpeticum is a serious skin infection caused by herpes simplex virus 1 or 2. It is commonly observed in children with atopic eczema and is characterized by a rapidly progressing painful rash. The infection can be life-threatening, which is why it is important to seek medical attention immediately.

      During examination, doctors typically observe monomorphic punched-out erosions, which are circular, depressed, and ulcerated lesions that are usually 1-3 mm in diameter. Due to the severity of the infection, children with eczema herpeticum should be admitted to the hospital for intravenous aciclovir treatment. It is important to understand the symptoms and seek medical attention promptly to prevent any complications.

    • This question is part of the following fields:

      • Dermatology
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