FCA1-0592
An acidic drug with a pKA of 4.3 is injected intravenously into a patient. At a normal physiological pH, the approximate ratio of ionised to unionised forms of this drug in the plasma is?
Archives: FRCA Part 1
FCA1-0593
A 26-year old man is admitted to the high dependency unit following an external fixation of a pelvic fracture sustained in a road traffic accident earlier in the day. Additionally, he has stable L2/L4 vertebral fractures but no other injuries. He is a known intravenous drug abuser currently on 200 mg heroin per day. He has been admitted for observations postop and pain control. He has regular paracetamol and NSAIDs prescribed. Which is the most appropriate postoperative pain regimen?
FCA1-0594
Glyceryl trinitrate (GTN) used for the acute treatment of angina is best administered via the sublingual route. Why is this the best route of administration?
FCA1-0587
Because this benzodiazepine has a half-life of 2-4 hours, it is preferred for clinical use. This benzodiazepine has which of the following properties that no other benzodiazepine has?
FCA1-0588
Under general anaesthesia, a 48-year-old patient is scheduled for some dental extractions. He tells you that he has a heart murmur and that he has always received antibiotic prophylaxis at the dentist. There are no allergies that he is aware of. Which antibiotic prophylaxis strategy is most appropriate for this patient?
FCA1-0589
A 6-year-old child is scheduled for general anaesthesia day surgery. You decide to perform an inhalational induction because he is otherwise medically fit. Which of the following is the most important factor in deciding which volatile anaesthetic agents to use?
FCA1-0590
A new intravenous neuromuscular blocking agent has been developed. It has a hepatic extraction ratio of 0.25 and three quaternary nitrogen atoms in its structure. It has been discovered that it has a half-life of fifteen minutes in healthy volunteers. Which of the following elimination mechanisms is the most likely to explain this pharmacological behaviour?
FCA1-0591
A weakly acidic drug with a pKa of 8.4 is injected intravenously into a patient. At a normal physiological pH, the percentage of this drug unionised in the plasma is?
FCA1-0583
Which of the following statements most accurately describes a drug’s efficacy or intrinsic activity?
FCA1-0584
The following are the pharmacodynamic properties of a neuromuscular blocking agent: Effective dose 95 (ED95) – 0.3 mg/kg, Time to 95% depression of first twitch of train of four (ToF) – 75 seconds, Time to 25% recovery of first twitch of train of four (ToF) – 33 minutes. Which of the following statements about this neuromuscular blocking agent is the most accurate?