FCA1-0566
Which of the following factors significantly increases the risk of hepatotoxicity and fulminant hepatic failure in halothane administration?
Archives: FRCA Part 1
FCA1-0567
A 39-year old man came to the Out-Patient department for symptoms of gastroesophageal reflux disease. Medical history revealed he is on anti-epileptic medication Phenytoin. His plasma phenytoin levels are maintained between 10-12 mcg/mL (Therapeutic range: 10-20 mcg/mL). He is given a H2 antagonist receptor agent (Cimetidine) for his GERD symptoms. Upon follow-up, his plasma phenytoin levels increased to 38 mcg/mL. Regarding metabolism and elimination, which of the following best explains the pharmacokinetics of phenytoin at higher plasma levels?
FCA1-0551
An 80-year old female was taken to the emergency room for chest pain. She has a medical history of coronary artery disease and previous episodes of atrial fibrillation. She was immediately attached to the cardiac monitor, which showed tachycardia at 148 beats per minute. The 12-lead ECG revealed atrial fibrillation. Digoxin was given as an anti-arrhythmic at 500 micrograms, which is higher than the maintenance dose routinely given. Why is this so?
FCA1-0552
A 47-year old man and known alcoholic suffered a fall that resulted to a fracture on his right leg. Radiographic imaging showed a fractured tibial shaft. Following surgery, you were instructed to prescribe intravenous paracetamol as an analgesic. If the patient weighs 49 kg, which of the following would be the best regimen for the patient?
FCA1-0553
What does therapeutic index in humans mean?
FCA1-0554
A strict diet is mandatory for which of the following drugs for mood disorders?
FCA1-0555
Regarding management of chronic pain, which of the following describes the mode of action of gabapentin?
FCA1-0556
A subject in a study is to take 100 mg of tramadol tablets for the next eight hours. Urine samples will be taken during the 8-hour course, which will undergo analysis via liquid chromatography. Given the following metabolites, which one would have the highest analgesic property?
FCA1-0560
Drug toxicity when using bupivacaine is most likely to occur when this local anaesthetic technique is performed.
FCA1-0561
A post-operative patient was given paracetamol and pethidine for post-operative analgesia. A few hours later, the patient developed fever of 38°C, hypertension, and agitation. According to the patient’s medical history, he is maintained on Levodopa and Selegiline for Parkinson’s disease. Which of the following is the most probable cause of his manifestation?