A 68-year-old man with nausea and vomiting is admitted to the hospital. For temporal arteritis, he takes 40 mg prednisolone orally in divided doses. His prescription chart will need to be adjusted to reflect his inability to take oral medications. What is the equivalent dose of intravenous hydrocortisone to 40 mg oral prednisolone?
In asthmatic patients, non-steroidal anti-inflammatory analgesics (NSAIDs) are generally contraindicated. Which of the following membrane phospholipid metabolism products is most likely to cause NSAID-induced bronchospasm in asthmatic patients who are predisposed to it?
You decide to conduct research on the normal rates of gastric emptying in healthy people. The strategy is to give a drug orally and measure plasma concentrations at predetermined intervals. Which of the following drugs would you choose to use?
Which oral hypoglycaemic agent has no effect on insulin sensitivity or secretion?
Which of the following drugs would cause the most clinical concern if accidentally administered intravenously to a 4-year-old boy?
The physiological properties of a fast glycolytic (fast twitch) muscle fibre are characterised by which of the following?
After consuming 12 g of paracetamol, a 37-year-old man is admitted to the medical admissions unit. He has hepatocellular necrosis in both clinical and biochemical aspects. The most significant reason for paracetamol causing toxicity is?
A new volatile anaesthetic agent has been approved for use in clinical testing. It’s a non-irritating, sweet-smelling substance. It has a molecular weight of 170, a 0.6 blood:gas partition coefficient, and a 180 oil:gas partition coefficient. An oxidative pathway converts 2% of the substance to trifluoroacetic acid. Which of the following statements best describes this agent’s pharmacological profile?
The pharmacologically inactive precursor of barbiturates is Barbituric acid. Because the molecule is heterocyclic, small structural changes can alter its pharmacological activity (structure function relationship). Which of the following modifications to the molecule has the greatest impact on the effectiveness of the barbiturate derivative?
You’ve been summoned to the recovery room to examine a 28-year-old man who has had an inguinal hernia repaired. His vital signs are normal, but you notice that he has developed abnormal upper-limb movements due to muscle contractions that cause repetitive twisting movements. What do you think is the most likely source for this patient’s condition?