mrcem2-0738

You evaluate a 42-year-old woman with a history of increasing fatigue and overall discomfort. Her blood test results are as follows:
Bilirubin 19 mmol (3-20)
ALT 338 IU/L (5-40)
ALP: 256 IU/L (20-140)
IgM: 2.4 g/L (0.5-2.5)
IgG: 28 g/L (7.5-15)
IgA: 1.5 g/L (1-4)
ANA: positive
SMA: positive
What is the MOST likely diagnosis?