mrcem2-1133

A 65-year-old patient presents with nausea and vomiting and decreased urine output. He has only produced a small amount of urine in the last day, and he has noticeable swelling in his ankles. His blood tests show a sudden increase in his creatinine levels in the last 48 hours, leading to a diagnosis of acute kidney injury (AKI).
What is an example of an intrinsic renal cause of AKI?