AKT-1624
A 25 year old male smoker presents with multiple, painful aphthous ulcers, he puts this down to stress at work. He only gets ulcers on his tongue and oral mucosa. He is otherwise well. He has never had any joint or bowel symptoms. He reports several previous episodes similar to this one, with painful oral ulceration lasting a week or two, dating back to when he was a teenager.
What signs or symptoms should prompt an immediate referral to secondary care for this 25 year old male smoker with recurrent painful oral ulcers?