AKT-3716

AKT-3716

You are examining the most recent blood test results for a patient with type 2 diabetes mellitus who is in their 60s. The patient is currently taking simvastatin 20 mg, metformin 1g twice daily, and gliclazide 80 mg twice daily. The patient’s latest renal function results are as follows:

– Sodium (Na+): 141 mmol/l
– Potassium (K+): 3.9 mmol/l
– Urea: 5.2 mmol/l
– Creatinine: 115 µmol/l

What is the creatinine threshold at which NICE recommends considering a change in metformin dosage?