AKT-4228
A 39-year-old teacher is being evaluated after starting an antidepressant. She initially presented with various symptoms of depression and a PHQ-9 score of 18. She has experienced several significant life events leading up to her diagnosis.
She is married with a daughter in college, but has a strong support system from her family. You decided to initiate treatment with sertraline 50 mg, but she reports no improvement in her depression and your assessment agrees.
Despite the lack of effectiveness in her treatment thus far, she appears to be tolerating the medication without any adverse effects.
Based on NICE guidelines for depression treatment, at what point in her treatment would you consider increasing the dosage if she has not responded?