A new treatment for juvenile arthritis has been developed and shown to be effective in animal models, plus its effects in small numbers of patients appears promising.
However, there are some concerns with regard to possible hepatotoxicity but no cases have been observed in studies thus far.
Which is the most appropriate next step in this drug’s development?
A 55-year-old man with dyslipidaemia, hypertension and angina has recently been diagnosed with impaired glucose tolerance (IGT).
Clinically he is obese with a BMI of 33 kg/m2, his blood pressure is 145/85 mmHg. He is aware that having impaired glucose tolerance is a risk factor for type 2 diabetes and would like to discuss strategies to attenuate this risk.
Which of the following has been shown best to reduce the incidence of type 2 diabetes in individuals with IGT?
Which of the following is a risk factor for bowel cancer?
What is the highest ranked source of evidence in the hierarchy of evidence based medicine?
A 60-year-old man with a BMI of 32 kg/m2 has uncontrolled hypertension, with a blood pressure of 165/88 mmHg. He doesn’t currently receive treatment for his hypertension.
He has normal glucose tolerance (no evidence of impaired fasting glycaemia, impaired glucose tolerance or diabetes).
When considering treatment of his hypertension which of these drugs has been shown to be associated with an increase in the risk of developing diabetes compared with an ACE inhibitor or ARB?
You plan to look at the effectiveness of a Chlamydia screening programme on detection rates for the disease among teenagers at the clinic.
The research is designed to look merely at detection rates, not the effectiveness of treatment.
Which of the following is true with respect to rules around ethical approval and consent for this project?
A study of individuals with cognitive impairment was conducted. The 112 participants who underwent program A demonstrated an average increase of 6 points in their IQ score. On the other hand, the 115 participants who underwent program B showed an average increase of 4 points in their IQ score. The p value was greater than 0.05. What is accurate?
A 68-year-old male presents with a productive cough with regular sputum production, wheeze and breathlessness on exertion.
On examination his FEV1 is 75% of predicted with no diurnal variation. He has smoked 30 cigarettes a day for the past 50 years.
What is considered to be the most appropriate aspect of the long term management in this patient?
Which statements accurately describe an intention to treat analysis?
If you were looking at evidence about which age group is most susceptible to psychiatric disturbance in patients taking Tamiflu, in what type of study would you be most likely to find it?