Archives: MRCGP AKT

AKT-5603

What is the single conclusion that can be drawn from the findings of the Veterans Affairs Laryngeal Study Group in 1991, which compared two treatments for advanced laryngeal cancer – laryngectomy followed by radiotherapy versus chemotherapy followed by radiotherapy? The study randomly assigned 332 patients with advanced laryngeal cancer to one of the groups, and those in the chemotherapy group who did not respond to treatment underwent salvage laryngectomy. The results showed that both groups had a 2-year survival rate of 68%, but a higher percentage of chemotherapy patients (64%) were able to retain their larynx. Additionally, more local recurrences occurred in the chemotherapy group, while fewer distant metastases occurred in the same group.

AKT-5592

For which patients is a quadrivalent seasonal influenza vaccination recommended?

AKT-5594

A novel oral hypoglycaemic agent has been developed to manage type 2 diabetes (drug B). A recently published paper appears to show very favourable results for this drug. A brief extract is given below.
‘Patients were recruited from outpatient clinics to receive drug B. A questionnaire developed by the trial coordinator was filled out by the clinician if they felt a patient might be suitable for the trial and these were collated by the trial coordinator. Baseline blood tests were taken at this time. Suitable patients were then selected by the coordinator and invited to join the trial. The group had the following characteristics: 32% female, 96% white, 2% black, 2% Asian. They were given drug B to take for a 12-month period. At the end of the trial questionnaires were given out to patients who were still taking the drug to evaluate side-effects and repeat blood tests were taken.’
Which of the following is the correct statement regarding the trial described above?

AKT-5591

A study is designed to assess the safety of recombinant human erythropoietin (rhEPO) when used in premature infants of less than 32 weeks gestation to reduce postnatal haemoglobin decline. Out of 29 infants given the treatment, none suffered serious side-effects.

AKT-5600

A completely well pregnant woman in her 20s comes to see you because she has been in contact with a child who has been diagnosed with measles.

Her exposure to the child was within six days of the onset of rash in the affected child. She has not been immunised against measles and she doesn’t think that she has contracted measles in the past.

How would you manage this woman?

AKT-5599

A 65-year-old Caucasian smoker presents to you with a two month history of a cough. The cough is non-productive, but he has coughed up spots of blood on occasion. He has also lost 10 pounds in weight, which he attributes to a reduced appetite since his wife started a healthy eating regime at home.

Upon examination, he has lost weight, but he is afebrile and appears to be in good health. His 4-year-old grandson whom he sees twice a week has recently been diagnosed with whooping cough, and he wonders if he could have whooping cough as well.

What is the most probable diagnosis?

AKT-5595

You are researching month-on-month changes in septoplasty rates nationally.
Select from the options the best source of information.

AKT-5593

A 28-year-old woman presents to your clinic seeking advice on quitting smoking. You plan to initiate bupropion therapy for her, but a few days later, you receive a call from the local emergency consultant informing you that she was admitted in status epilepticus. It turns out that you were not aware of her other medications. Which of the following drugs, when taken concomitantly with bupropion, may increase the risk of seizures?

AKT-5598

A 62-year-old man is found to have a raised cholesterol level on routine blood tests. His blood pressure is normal; he is not diabetic, and his QRISK®3 score is 15%. He drinks 12 units of alcohol per week.
What would be the most appropriate management option in this case?

AKT-5590

Among certain ethnic groups, there is evidence of higher prevalence of certain diseases. Which disease has NOT been found to be more prevalent among Black Caribbean men? Choose ONE option from the list.