AKT-5595
You are researching month-on-month changes in septoplasty rates nationally.
Select from the options the best source of information.
Archives: MRCGP AKT
AKT-5600
A completely well pregnant woman in her 20s comes to see you because she has been in contact with a child who has been diagnosed with measles.
Her exposure to the child was within six days of the onset of rash in the affected child. She has not been immunised against measles and she doesn’t think that she has contracted measles in the past.
How would you manage this woman?
AKT-5580
A researcher is designing a crossover trial to study the efficacy of a new antiviral medication versus a placebo for treating influenza in elderly patients. The medication being studied has a very short half-life. The sample size that is available to the researcher for this trial is small but there is a long time period available for the trial to be completed. All of the elderly patients that have agreed to take part in the study are expecting to receive the active treatment.
Which of these factors may make a crossover trial unsuitable in this case?
AKT-5583
A new drug is being developed to treat chronic obstructive pulmonary disease (COPD). It has been found to be safe in elderly volunteers and seems effective in small-scale trials in elderly patients. The therapeutic effects of the drug do not persist for long after it has been stopped.
What is the most appropriate study design for the next phase of trials?
AKT-5584
A 31-year-old patient presents to you seeking help with quitting smoking. He currently smokes 20-30 cigarettes per day. After counseling him on his options, you decide to prescribe bupropion. As per NICE guidelines, what is the recommended duration for the initial prescription of bupropion?
AKT-5581
When investigating the impact of patients’ attitudes, beliefs, and knowledge of health literature on the management of chronic mechanical low back pain, researchers typically establish inclusion and exclusion criteria for their patient sample. Which of the following options is most likely to be an exclusion criterion?
AKT-5578
Out of 15 individual trials included in a meta-analysis examining the impact of beta-blockers on survival following a heart attack, two demonstrated enhanced survival while 13 did not show any advantage. However, the combined outcomes of all the trials indicated a significant decrease in mortality with beta-blockers. What is the most probable explanation for the lack of benefit observed in some trials?
AKT-5579
Which statement accurately interprets the data from a review of statin trials, including the trial type, number of patients, drug used, and relative risk of cardiac event in the treatment arm for each trial?
AKT-5577
Which of the following is most likely to indicate bias in a meta-analysis of randomized controlled trials focused on elderly populations? The authors select papers from studies across the world and carry out various analyses, including funnel plots. They declare no conflicts of interest.
AKT-5576
What proportion of the population in the United Kingdom has coeliac disease?