AKT-5589

What is the research methodology used by researchers to understand why general practitioners prescribe antibiotics for some cases of sore throat and to explore factors that influence their prescribing? The researchers selected 25 general practitioners who reflect a wide variety of characteristics that might influence prescribing and were selected from different places to avoid regional bias. A single researcher conducted face-to-face, open-ended interviews at participants’ surgeries using an interview guide. As the study progressed, a further theoretical sample of 15 general practitioners was added, this selection being guided by the emerging analysis.

AKT-5573

A randomised controlled trial was conducted to test a new treatment for preventing recurrence of stroke. The trial involved 1000 patients who were randomly assigned to receive the new treatment and another 1000 patients who received standard therapy. During the trial, 66 patients who received the new treatment suffered a recurrent stroke, while 110 patients in the control group experienced the same outcome. What is the relative risk reduction in the treatment group?

AKT-5587

A group of elderly patients are being prescribed a newly licensed antidepressant, which has been reported in journals as having superior efficacy and tolerability to alternatives in its class. Nonetheless, after some months, the drug is withdrawn from the market because of an unexpected number of serious adverse reactions reported through drug surveillance schemes.
Which of the following is the most likely reason for this?

AKT-5579

Which statement accurately interprets the data from a review of statin trials, including the trial type, number of patients, drug used, and relative risk of cardiac event in the treatment arm for each trial?

AKT-5582

A study is being planned to investigate the association between environmental exposure to pesticides and the incidence of cancer in elderly individuals. The researchers have limited funding for the study and need to keep the length and cost of the trial to a minimum.
What is the most appropriate study design?

AKT-5588

A 32-year-old patient presents to you seeking pre-pregnancy advice and inquiring about folic acid intake. The patient has a medical history of insulin-treated type 1 diabetes. What recommendations would you make regarding the duration and dosage of folic acid supplementation?

AKT-5575

In a study comparing a drug aimed at reducing the risk of cardiovascular events with a placebo, data was collected from two groups of 1000 individuals each. The placebo group had 150 cardiovascular events while the drug treatment group had 100. What is the correct percentage absolute risk reduction based on these results?

AKT-5584

A 31-year-old patient presents to you seeking help with quitting smoking. He currently smokes 20-30 cigarettes per day. After counseling him on his options, you decide to prescribe bupropion. As per NICE guidelines, what is the recommended duration for the initial prescription of bupropion?

AKT-5581

When investigating the impact of patients’ attitudes, beliefs, and knowledge of health literature on the management of chronic mechanical low back pain, researchers typically establish inclusion and exclusion criteria for their patient sample. Which of the following options is most likely to be an exclusion criterion?

AKT-5572

A 31-year-old construction worker visits your clinic with concerns about his anxiety. As you talk with him, he reveals that he drinks two bottles of beer every evening. These bottles are 500 ml each and have an alcohol by volume (ABV) of 5%.

How many units of alcohol does he consume per week?