Category: Endocrinology

MRCP-0407

Which one of the following types of thyroid cancer is associated with the RET oncogene?

MRCP-0408

A 26-year-old man with type-1 diabetes presents for review. His HbA1c is 6.8% yet he is concerned that his morning blood sugar levels are occasionally as high as 24 mmol/l. He is currently managed on a bd mixed insulin regime. He was sent for continuous glucose monitoring and his glucose profile reveals dangerous dipping in blood glucose levels during the early hours of the morning. Which of the following changes to his insulin regime is most appropriate?

MRCP-0409

A 16-year-old boy is being treated with ADH for diabetes insipidus. His blood results show: fasting plasma glucose level: 6 mmol/l (3– 6), sodium 148 mmol/l (137–144), potassium 4.5 mmol/l (3.5–4.9), calcium 2.8 mmol/l (2.2–2.6). However, he still complains of polyuria, polydipsia and nocturia. What could be the most probable cause?

MRCP-0410

A 17-year-old Jewish girl presents with primary amenorrhoea. On examination, she looks a little hirsute and has evidence of facial acne. She is within her predicted adult height and has normal breast and external genitalia development, however, there is excess hair over her lower abdomen and around her nipple area. Investigations were as follows: Hb 13.1 g/dL, WCC 8.6 x109/L, PLT 201 x109/L, Na+ 139 mmol/L, K+ 4.5 mmol/L, Creatinine 110 µmol/L, 17-OH progesterone 1.4 times the upper limit of normal. Pelvic ultrasound: bilateral ovaries and uterus visualised. Which of the following is the most likely diagnosis?

MRCP-0411

A 30-year-old lawyer presents with non-specific symptoms of tiredness. Blood tests reveal normal thyroid function, cortisol, growth hormone and gonadotrophins. Pituitary MRI reveals a 0.8cm microadenoma. Which of the following represents the most appropriate course of action?

MRCP-0412

A 25-year-old obese woman is diagnosed with polycystic ovarian syndrome (PCOS). Which of the following findings is most consistently seen in PCOS?

MRCP-0402

A collapsed patient comes into A&E. He has a steroid user card and empty boxes of prednisolone. He has obvious rheumatoid features on examination and some unilateral consolidation on his chest X-ray. He is given intravenous fluids and broad-spectrum antibiotics. Which one of the following would be the most useful addition to the current management?

MRCP-0403

A 15-year-old boy presents with poor development of secondary sex characteristics, colour blindness and a decreased sense of smell. On examination, his testes are small soft and located in the scrotum. What is the most probable diagnosis?

MRCP-0404

A 25-year-old man wants to start a relationship but is concerned about his small phallus. He also has difficulty becoming aroused. On examination, he is slim and has gynecomastia. There is a general paucity of body hair, his penis and testes are small. Which diagnosis fits best with this history and examination?