A 30-year-old woman presents with amenorrhoea and galactorrhoea. She has normal visual fields. You are concerned that she may have a prolactinoma. Investigations were done and the results are as shown below: Hb 12.5 g/dL, WCC 4.9 x109/L, PLT 199 x109/L, Na+ 140 mmol/L, K+ 4.9 mmol/L, Creatinine 90 ىmol/L, Prolactin 1150 mU/l. MRI shows a 7 mm pituitary microadenoma. Which of the following hormones would you expect to be lower than normal?
A 50-year-old man is referred with impotence. He has a history of angina, hypertension and type 2 diabetes. Which one of the following drugs that he takes is a contraindication to him being able to receive sildenafil?
All of the following statements regarding glucagon-like peptide-1 (GLP-1) are true, except?
A 44-year-old woman is investigated for hot flushes and night sweats. Her blood tests show a significantly raised FSH level and her symptoms are attributed to menopause. Following discussions with the patient, she elects to have hormone replacement treatment. What is the most significant risk of prescribing an oestrogen-only preparation rather than a combined oestrogen-progestogen preparation?
A 65-year-old man with a history of type 2 diabetes comes to the clinic for review. His HbA1c is elevated at 64 mmol/mol despite taking 1g of metformin BD. On examination, his blood pressure is 142/88 mmHg, his pulse is 82 beats per minute and regular. His BMI is 33 kg/m². A decision is made to start him on dapagliflozin. Which of the following would you expect on starting therapy?
Which of the following is correct regarding post-menopausal hormone replacement therapy (HRT) according to randomised clinical studies ?
A 60–year-old woman comes to the hospital for chemotherapy for breast cancer. On examination, her pulse is 120 bpm and regular and BP is 90/60. Her JVP is not seen, her heart sounds are normal, and her chest is clear. There is evidence of a right mastectomy. Abdominal and neurological examination is normal.
Short synacthen test was ordered and the results came as follows:
Time (min): 0, 30, 60.
Cortisol (nmol/l): 90, 130, 145.
Which two of the following would be your immediate management?
A 22-year-old woman presents with anxiety and weight loss with increased appetite. Thyrotoxicosis is suspected and various investigations are performed. Which of the following findings is most consistent with Graves’ disease?
A 26-year-old woman presents for her first cervical smear. What is the most important aetiological factor causing cervical cancer?
Which of the following is most consistent with small cell lung cancer?