MRCP2-1232

A 45-year-old woman presents with a one-year history of tiredness, weight gain, and fatigue. She had undergone trans-sphenoidal resection of a non-functioning pituitary tumor two years ago, which resulted in pan-hypopituitarism. Currently, she is being treated with hydrocortisone, thyroxine, and oral contraceptive Logynon. On examination, her blood pressure is 110/64 mmHg, and her pulse is 80 bpm. Her free T4 level is 12.5 pmol/L, plasma TSH is 0.2 mU/L, and serum estradiol is <80 pmol/L. What is the most appropriate treatment for her fatigue?