MRCP2-2375

MRCP2-2375

A 54-year-old woman presents to her GP with complaints of fatigue and bruising. She has no significant medical history. After an abnormal full blood count, she is referred to the haematology clinic. The following are her blood results:

– Hb: 112 g/L (Female: 115 – 160 g/L)
– Platelets: 150 * 109/L (150 – 400 * 109/L)
– WBC: 25.3 * 109/L (4.0 – 11.0 * 109/L)
– Neuts: 4.0 * 109/L (2.0 – 7.0 * 109/L)
– Lymphs: 16.2 * 109/L (1.0 – 3.5 * 109/L)
– Mono: 3.0 * 109/L (0.2 – 0.8 * 109/L)
– Eosin: 1.1 * 109/L (0.0 – 0.4 * 109/L)

Her LDH level is 250 U/L (140 – 280 U/L). Multicolour flow cytometry assay reports CD20+, CD23+, and CD5+ expression. Fluorescence in situ hybridization (FISH) reveals a deletion in the short arm of chromosome 17.

What is the feature associated with a poor prognosis in this case?