MRCP2-2450
A 38-year-old woman has been admitted to the ICU two days after receiving her third cycle of chemotherapy for malignant ovarian cancer. She had been discharged without complications but developed a fever and was admitted to the Medical Admission Unit. Despite treatment for neutropaenic sepsis, she continued to deteriorate and developed hemiparesis and a decreased level of consciousness. Upon arrival at the ICU, her vital signs were unstable and she had evidence of schistocytes and normocytic normochromic anemia on blood film. What is the most appropriate immediate management step given the likely underlying diagnosis?